CYP26A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in gastrulation (GO:0042074)9.43158887
2negative regulation of activin receptor signaling pathway (GO:0032926)7.50250901
3regulation of mesoderm development (GO:2000380)7.30105169
4signal transduction involved in regulation of gene expression (GO:0023019)6.99200972
5endoderm formation (GO:0001706)6.59401401
6secondary heart field specification (GO:0003139)5.87671446
7heart field specification (GO:0003128)5.87671446
8DNA replication checkpoint (GO:0000076)5.87322933
9serine family amino acid biosynthetic process (GO:0009070)5.67090857
10L-serine metabolic process (GO:0006563)5.47143994
11L-phenylalanine metabolic process (GO:0006558)5.41194779
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.41194779
13regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.39754354
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.33138835
15L-phenylalanine catabolic process (GO:0006559)5.33138835
16negative regulation of cell fate specification (GO:0009996)5.23573537
17phospholipid scrambling (GO:0017121)5.18097922
18regulation of activin receptor signaling pathway (GO:0032925)5.15840848
19sequestering of extracellular ligand from receptor (GO:0035581)5.14576945
20glycine metabolic process (GO:0006544)5.12129523
21regulation of cardioblast differentiation (GO:0051890)5.05649567
22otic vesicle formation (GO:0030916)5.04162506
23response to BMP (GO:0071772)5.04108235
24cellular response to BMP stimulus (GO:0071773)5.04108235
25embryonic foregut morphogenesis (GO:0048617)5.03850406
26gastrulation (GO:0007369)5.02788429
27primitive streak formation (GO:0090009)4.93233216
28positive regulation of urine volume (GO:0035810)4.90570452
29female gonad development (GO:0008585)4.79049337
30aromatic amino acid family catabolic process (GO:0009074)4.64414581
31dorsal/ventral axis specification (GO:0009950)4.46286536
32serine family amino acid metabolic process (GO:0009069)4.44776880
33CENP-A containing nucleosome assembly (GO:0034080)4.42803533
34embryonic axis specification (GO:0000578)4.42350370
35chromatin remodeling at centromere (GO:0031055)4.40748704
36negative regulation of fatty acid biosynthetic process (GO:0045717)4.38103413
37somite rostral/caudal axis specification (GO:0032525)4.37596576
38organ formation (GO:0048645)4.33501928
39kynurenine metabolic process (GO:0070189)4.32397607
40synapsis (GO:0007129)4.25076155
41folic acid-containing compound biosynthetic process (GO:0009396)4.23446492
42muscle organ morphogenesis (GO:0048644)4.23389413
43urea metabolic process (GO:0019627)4.20152589
44urea cycle (GO:0000050)4.20152589
45tetrahydrofolate metabolic process (GO:0046653)4.11458363
46negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.09671748
47serine family amino acid catabolic process (GO:0009071)4.07963558
48homocysteine metabolic process (GO:0050667)4.06284791
49tryptophan catabolic process (GO:0006569)4.05931524
50indole-containing compound catabolic process (GO:0042436)4.05931524
51indolalkylamine catabolic process (GO:0046218)4.05931524
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.05223817
53bile acid biosynthetic process (GO:0006699)4.04644492
54digestive tract morphogenesis (GO:0048546)4.03988388
55cysteine metabolic process (GO:0006534)4.01549357
56alpha-linolenic acid metabolic process (GO:0036109)3.99140036
57negative regulation of fibrinolysis (GO:0051918)3.97326959
58one-carbon metabolic process (GO:0006730)3.96411659
59glyoxylate metabolic process (GO:0046487)3.94612929
60epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.94034180
61SMAD protein signal transduction (GO:0060395)3.91741289
62imidazole-containing compound metabolic process (GO:0052803)3.90229141
63negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.87316070
64regulation of protein activation cascade (GO:2000257)3.86704574
65histone exchange (GO:0043486)3.85260075
66nitrogen cycle metabolic process (GO:0071941)3.84559575
67sulfur amino acid catabolic process (GO:0000098)3.84175688
68complement activation, alternative pathway (GO:0006957)3.82724418
69atrioventricular valve morphogenesis (GO:0003181)3.82131046
70positive regulation of SMAD protein import into nucleus (GO:0060391)3.80721582
71tryptophan metabolic process (GO:0006568)3.80677016
72nodal signaling pathway (GO:0038092)3.78760019
73DNA replication-dependent nucleosome assembly (GO:0006335)3.70029632
74DNA replication-dependent nucleosome organization (GO:0034723)3.70029632
75regulation of fibrinolysis (GO:0051917)3.66678225
76regulation of complement activation (GO:0030449)3.65349801
77positive regulation of cardiac muscle cell proliferation (GO:0060045)3.63989765
78kinetochore organization (GO:0051383)3.63786935
79receptor guanylyl cyclase signaling pathway (GO:0007168)3.61224139
80regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.60922767
81embryonic retina morphogenesis in camera-type eye (GO:0060059)3.60852402
82cell migration involved in heart development (GO:0060973)3.58731323
83negative regulation of embryonic development (GO:0045992)3.55870113
84DNA replication-independent nucleosome organization (GO:0034724)3.55822013
85DNA replication-independent nucleosome assembly (GO:0006336)3.55822013
86axis specification (GO:0009798)3.50648983
87G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50348726
88anterior/posterior axis specification, embryo (GO:0008595)3.50301370
89regulation of glucocorticoid metabolic process (GO:0031943)3.49688148
90lateral sprouting from an epithelium (GO:0060601)3.49650428
91alpha-amino acid catabolic process (GO:1901606)3.46782202
92embryonic pattern specification (GO:0009880)3.45901225
93lysine metabolic process (GO:0006553)3.42402145
94lysine catabolic process (GO:0006554)3.42402145
95specification of organ identity (GO:0010092)3.39118783
96negative regulation of sterol transport (GO:0032372)3.38409717
97negative regulation of cholesterol transport (GO:0032375)3.38409717
98high-density lipoprotein particle remodeling (GO:0034375)3.37664203
99mitotic metaphase plate congression (GO:0007080)3.35853299
100regulation of urine volume (GO:0035809)3.35065004
101protein carboxylation (GO:0018214)3.34640172
102peptidyl-glutamic acid carboxylation (GO:0017187)3.34640172
103aromatic amino acid family metabolic process (GO:0009072)3.34095470
104oocyte development (GO:0048599)3.33219276
105negative regulation of cell fate commitment (GO:0010454)3.31543081
106kinetochore assembly (GO:0051382)3.31215182
107bile acid metabolic process (GO:0008206)3.31045002
108limb bud formation (GO:0060174)3.29947351
109notochord development (GO:0030903)3.29594765
110organ induction (GO:0001759)3.29084662
111cardiocyte differentiation (GO:0035051)3.28413436
112mesenchymal to epithelial transition (GO:0060231)3.24474052
113positive regulation of gastrulation (GO:2000543)3.23530216
114paraxial mesoderm development (GO:0048339)3.23278745
115glutamate metabolic process (GO:0006536)3.22017622
116positive regulation of cardiac muscle tissue growth (GO:0055023)3.21162885
117genitalia morphogenesis (GO:0035112)3.20493967
118dicarboxylic acid biosynthetic process (GO:0043650)3.19376244
119ethanol oxidation (GO:0006069)3.18314842
120anterior/posterior axis specification (GO:0009948)3.16822590
121protein localization to kinetochore (GO:0034501)3.15494091
122cellular amino acid catabolic process (GO:0009063)3.14554191
123amino-acid betaine metabolic process (GO:0006577)3.14385859
124tyrosine metabolic process (GO:0006570)3.13930312
125telencephalon development (GO:0021537)3.13441958
126folic acid-containing compound metabolic process (GO:0006760)3.10835358
127regulation of gastrulation (GO:0010470)3.10715535
128mitotic G2/M transition checkpoint (GO:0044818)3.09469616
129regulation of cholesterol homeostasis (GO:2000188)3.08694885
130regulation of transforming growth factor beta2 production (GO:0032909)3.07187295
131aldehyde catabolic process (GO:0046185)3.06752761
132negative regulation of fatty acid metabolic process (GO:0045922)3.04603112
133negative regulation of hormone biosynthetic process (GO:0032353)3.00893792
134positive regulation of cardiac muscle tissue development (GO:0055025)2.99862353
135lung morphogenesis (GO:0060425)2.98730896
136regulation of translational fidelity (GO:0006450)2.98391365
137ventricular cardiac muscle cell development (GO:0055015)2.96937825
138pteridine-containing compound biosynthetic process (GO:0042559)2.96798021
139negative regulation of cardiac muscle tissue development (GO:0055026)2.96524104
140regulation of cell fate specification (GO:0042659)2.95490687
141branching involved in salivary gland morphogenesis (GO:0060445)2.95435523
142regulation of tight junction assembly (GO:2000810)2.92124930
143regulation of cardiac muscle cell proliferation (GO:0060043)2.92115938
144pre-miRNA processing (GO:0031054)2.91907110
145negative regulation of axon extension involved in axon guidance (GO:0048843)2.91881911
146acylglycerol homeostasis (GO:0055090)2.91366616
147triglyceride homeostasis (GO:0070328)2.91366616
148plasma lipoprotein particle clearance (GO:0034381)2.91149233
149metaphase plate congression (GO:0051310)2.90989527
150regulation of triglyceride catabolic process (GO:0010896)2.89678236
151single strand break repair (GO:0000012)2.89299279
152regulation of cholesterol esterification (GO:0010872)2.89006026
153acetyl-CoA metabolic process (GO:0006084)2.88315220
154alpha-amino acid biosynthetic process (GO:1901607)2.88017134
155dorsal/ventral neural tube patterning (GO:0021904)2.87841971
156sister chromatid cohesion (GO:0007062)2.87308116
157folic acid metabolic process (GO:0046655)2.87068063
158pericardium development (GO:0060039)2.86340491
159fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.85244117
160positive regulation of renal sodium excretion (GO:0035815)2.84905977
161mitotic G2 DNA damage checkpoint (GO:0007095)2.84209599
162regulation of development, heterochronic (GO:0040034)2.81405444
163positive regulation of muscle organ development (GO:0048636)2.81323858
164positive regulation of striated muscle tissue development (GO:0045844)2.81323858
165negative regulation of androgen receptor signaling pathway (GO:0060766)2.79792954
166kidney morphogenesis (GO:0060993)2.78680255
167positive regulation of heart growth (GO:0060421)2.77844411
168regulation of SMAD protein import into nucleus (GO:0060390)2.77800392
169extracellular negative regulation of signal transduction (GO:1900116)2.75179869
170extracellular regulation of signal transduction (GO:1900115)2.75179869
171regulation of timing of cell differentiation (GO:0048505)2.74622605
172formation of primary germ layer (GO:0001704)2.74606335
173DNA ligation (GO:0006266)2.73561525
174ureteric bud development (GO:0001657)2.73411174
175positive regulation of muscle tissue development (GO:1901863)2.72867466
176regulation of cell fate commitment (GO:0010453)2.71100827
177regulation of stem cell maintenance (GO:2000036)2.69926999
178regulation of cardiac muscle tissue development (GO:0055024)2.69144016
179transcytosis (GO:0045056)2.69100897
180mitotic sister chromatid cohesion (GO:0007064)2.68747788
181somatic stem cell division (GO:0048103)2.68742164
182mesenchymal cell differentiation (GO:0048762)2.66323435
183establishment of integrated proviral latency (GO:0075713)2.65757168
184ATP-dependent chromatin remodeling (GO:0043044)2.64374755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.11518554
2E2F7_22180533_ChIP-Seq_HELA_Human4.68032127
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.56322383
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.19005979
5SMAD3_21741376_ChIP-Seq_HESCs_Human3.97721275
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.76890328
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.42694516
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.39376470
9* LXR_22158963_ChIP-Seq_LIVER_Mouse3.36343428
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20019189
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04409182
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.79906381
13SMAD4_21741376_ChIP-Seq_HESCs_Human2.77670017
14POU5F1_16153702_ChIP-ChIP_HESCs_Human2.62100987
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55625187
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.37998420
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.37998420
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.37998420
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.33417922
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.30989534
21XRN2_22483619_ChIP-Seq_HELA_Human2.18862904
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.17360712
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10113010
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09936193
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.08812178
26* SMAD3_21741376_ChIP-Seq_EPCs_Human2.03798609
27* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03471560
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02833176
29AR_21909140_ChIP-Seq_LNCAP_Human2.02570159
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97396065
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95712722
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.95082567
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.89800768
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.83810966
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82672160
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80849744
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76226543
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.73719989
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72454273
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.71896378
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70724939
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67883461
43* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66697411
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65309482
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64444015
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60277281
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.59666109
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59147092
49ELK1_19687146_ChIP-ChIP_HELA_Human1.50541938
50CLOCK_20551151_ChIP-Seq_293T_Human1.48237033
51* P300_19829295_ChIP-Seq_ESCs_Human1.47810123
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46423774
53OCT4_18692474_ChIP-Seq_MEFs_Mouse1.44128614
54* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43755064
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43420277
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43309830
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43262716
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43079430
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.41696611
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.41204821
61TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.39648624
62TTF2_22483619_ChIP-Seq_HELA_Human1.38615820
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37705462
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37248495
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37096164
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36845977
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36109908
68EWS_26573619_Chip-Seq_HEK293_Human1.33820625
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.32357209
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.31095278
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30998822
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29095894
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28480771
74* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27332717
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26661384
76VDR_22108803_ChIP-Seq_LS180_Human1.26263936
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.25984819
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25920186
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25204527
80NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23501880
81MYC_22102868_ChIP-Seq_BL_Human1.20731794
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20552893
83POU5F1_16518401_ChIP-PET_MESCs_Mouse1.20430830
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.19141567
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18139282
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17698537
87ZNF263_19887448_ChIP-Seq_K562_Human1.17414357
88SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16033127
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14712888
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14674583
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14519754
92TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.14254831
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13963868
94KDM5A_27292631_Chip-Seq_BREAST_Human1.13432736
95* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13242054
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13103731
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12535605
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11864669
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11546346
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11471245
101MYC_18940864_ChIP-ChIP_HL60_Human1.11096202
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10914603
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10437329
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10062991
105DCP1A_22483619_ChIP-Seq_HELA_Human1.09508326
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09222359
107TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08951992
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07583571
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07576018
110* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06980868
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05552963
112POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05495730
113CIITA_25753668_ChIP-Seq_RAJI_Human1.04773671
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04045721
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.03603734
116ATF3_27146783_Chip-Seq_COLON_Human1.02708323
117FUS_26573619_Chip-Seq_HEK293_Human1.02694705
118GABP_19822575_ChIP-Seq_HepG2_Human1.01270976
119NANOG_16153702_ChIP-ChIP_HESCs_Human1.00882679
120* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00100525
121TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00009351
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98288224
123* EED_16625203_ChIP-ChIP_MESCs_Mouse0.98226324
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97821576
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97565815
126KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96258352
127NANOG_16518401_ChIP-PET_MESCs_Mouse0.95217230
128RNF2_27304074_Chip-Seq_NSC_Mouse0.95128753
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94736133
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93342502
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93108113
132* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93080301
133SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92318049
134* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92279042
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90470047
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89783299
137NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88025280
138NANOG_21062744_ChIP-ChIP_HESCs_Human0.87662640
139ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87580348
140FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87236373
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86166680
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86119824
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85646579
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85451395
145FOXP3_21729870_ChIP-Seq_TREG_Human0.85370078
146IGF1R_20145208_ChIP-Seq_DFB_Human0.85102414
147* EOMES_21245162_ChIP-Seq_HESCs_Human0.83251204
148CBX2_27304074_Chip-Seq_ESCs_Mouse0.82944973
149MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82580401
150* EZH2_27304074_Chip-Seq_ESCs_Mouse0.81848159
151FOXP1_21924763_ChIP-Seq_HESCs_Human0.81781320
152PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81120685
153SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79928447
154POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.79553183
155ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79217540
156HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79142972
157SOX17_20123909_ChIP-Seq_XEN_Mouse0.77863311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.08601256
2MP0005360_urolithiasis5.38057738
3MP0003890_abnormal_embryonic-extraembry5.26733541
4MP0003806_abnormal_nucleotide_metabolis4.71382797
5MP0005085_abnormal_gallbladder_physiolo4.43139197
6MP0005365_abnormal_bile_salt4.16528138
7MP0005499_abnormal_olfactory_system3.90094933
8MP0005394_taste/olfaction_phenotype3.90094933
9MP0002234_abnormal_pharynx_morphology3.25214173
10MP0008875_abnormal_xenobiotic_pharmacok3.21549582
11MP0004133_heterotaxia2.85211442
12MP0008004_abnormal_stomach_pH2.85082502
13MP0003136_yellow_coat_color2.69519721
14* MP0003119_abnormal_digestive_system2.58826393
15MP0003252_abnormal_bile_duct2.47927527
16MP0010329_abnormal_lipoprotein_level2.38708461
17MP0005083_abnormal_biliary_tract2.22698170
18MP0000678_abnormal_parathyroid_gland2.20560684
19MP0002254_reproductive_system_inflammat2.19687802
20MP0004957_abnormal_blastocyst_morpholog2.09727921
21MP0002277_abnormal_respiratory_mucosa2.08241962
22MP0009840_abnormal_foam_cell2.05037071
23MP0005332_abnormal_amino_acid1.96876155
24MP0010030_abnormal_orbit_morphology1.93390209
25MP0002233_abnormal_nose_morphology1.88859292
26MP0006292_abnormal_olfactory_placode1.83593251
27MP0006054_spinal_hemorrhage1.82629837
28MP0001666_abnormal_nutrient_absorption1.82448430
29MP0001730_embryonic_growth_arrest1.78736330
30* MP0008932_abnormal_embryonic_tissue1.70359029
31MP0003283_abnormal_digestive_organ1.68224140
32MP0008789_abnormal_olfactory_epithelium1.65286863
33* MP0002084_abnormal_developmental_patter1.62890786
34MP0002736_abnormal_nociception_after1.60033348
35MP0001672_abnormal_embryogenesis/_devel1.57445332
36MP0005380_embryogenesis_phenotype1.57445332
37MP0001984_abnormal_olfaction1.54384332
38MP0003705_abnormal_hypodermis_morpholog1.52238999
39MP0005084_abnormal_gallbladder_morpholo1.50077558
40MP0004197_abnormal_fetal_growth/weight/1.46805834
41MP0003122_maternal_imprinting1.46015703
42MP0002160_abnormal_reproductive_system1.44840967
43MP0000609_abnormal_liver_physiology1.44570436
44MP0003077_abnormal_cell_cycle1.39284226
45MP0002653_abnormal_ependyma_morphology1.37286208
46MP0009053_abnormal_anal_canal1.36936574
47MP0000762_abnormal_tongue_morphology1.31048166
48MP0003693_abnormal_embryo_hatching1.29880088
49* MP0002111_abnormal_tail_morphology1.29315121
50MP0002932_abnormal_joint_morphology1.26571949
51MP0002088_abnormal_embryonic_growth/wei1.26105069
52MP0001286_abnormal_eye_development1.25559461
53MP0004019_abnormal_vitamin_homeostasis1.25393983
54MP0003984_embryonic_growth_retardation1.25194570
55MP0005319_abnormal_enzyme/_coenzyme1.24689654
56MP0000372_irregular_coat_pigmentation1.23807623
57MP0001697_abnormal_embryo_size1.21937750
58MP0000537_abnormal_urethra_morphology1.19949730
59* MP0002085_abnormal_embryonic_tissue1.19920022
60MP0002163_abnormal_gland_morphology1.17778189
61MP0003567_abnormal_fetal_cardiomyocyte1.17490845
62MP0003195_calcinosis1.16794741
63MP0000428_abnormal_craniofacial_morphol1.12743556
64* MP0003937_abnormal_limbs/digits/tail_de1.10717308
65MP0003121_genomic_imprinting1.10579439
66MP0000598_abnormal_liver_morphology1.10148004
67MP0009384_cardiac_valve_regurgitation1.09921667
68MP0003942_abnormal_urinary_system1.07663574
69MP0002118_abnormal_lipid_homeostasis1.07038990
70MP0001529_abnormal_vocalization1.06965984
71MP0010094_abnormal_chromosome_stability1.03819443
72MP0003011_delayed_dark_adaptation1.03593894
73MP0002086_abnormal_extraembryonic_tissu1.02983991
74MP0005670_abnormal_white_adipose1.02817841
75MP0002138_abnormal_hepatobiliary_system1.02652053
76MP0002249_abnormal_larynx_morphology1.02203760
77MP0006072_abnormal_retinal_apoptosis1.00173238
78MP0005266_abnormal_metabolism0.99555134
79MP0003755_abnormal_palate_morphology0.97422611
80MP0003943_abnormal_hepatobiliary_system0.95582479
81MP0005187_abnormal_penis_morphology0.93850286
82MP0002127_abnormal_cardiovascular_syste0.93358419
83* MP0002080_prenatal_lethality0.93223172
84MP0010234_abnormal_vibrissa_follicle0.91395756
85MP0003566_abnormal_cell_adhesion0.90849359
86MP0003279_aneurysm0.90400448
87MP0001915_intracranial_hemorrhage0.89083962
88MP0003186_abnormal_redox_activity0.88942319
89MP0003191_abnormal_cellular_cholesterol0.84221238
90* MP0003935_abnormal_craniofacial_develop0.83834279
91MP0002332_abnormal_exercise_endurance0.82584964
92MP0002938_white_spotting0.82277819
93MP0008995_early_reproductive_senescence0.82110762
94MP0009672_abnormal_birth_weight0.81666101
95MP0003938_abnormal_ear_development0.81443631
96MP0008058_abnormal_DNA_repair0.80767032
97MP0001764_abnormal_homeostasis0.79749676
98MP0000049_abnormal_middle_ear0.79728657
99MP0000350_abnormal_cell_proliferation0.79581790
100MP0002102_abnormal_ear_morphology0.79249235
101MP0000534_abnormal_ureter_morphology0.78843243
102MP0003111_abnormal_nucleus_morphology0.78617947
103MP0002751_abnormal_autonomic_nervous0.77236445
104MP0005389_reproductive_system_phenotype0.75739975
105MP0003868_abnormal_feces_composition0.74939878
106MP0005248_abnormal_Harderian_gland0.74204670
107MP0005584_abnormal_enzyme/coenzyme_acti0.72923279
108MP0002092_abnormal_eye_morphology0.72566302
109* MP0000432_abnormal_head_morphology0.72524420
110MP0002177_abnormal_outer_ear0.71685059
111MP0002269_muscular_atrophy0.71182510
112MP0002132_abnormal_respiratory_system0.70745737
113MP0003718_maternal_effect0.68423830
114MP0010352_gastrointestinal_tract_polyps0.68301526
115* MP0002109_abnormal_limb_morphology0.67269881
116MP0003880_abnormal_central_pattern0.65980091
117MP0003941_abnormal_skin_development0.65295562
118* MP0003861_abnormal_nervous_system0.64376266
119MP0001293_anophthalmia0.63657404
120MP0000538_abnormal_urinary_bladder0.63608259
121MP0002697_abnormal_eye_size0.63337026
122MP0002116_abnormal_craniofacial_bone0.62829184
123MP0004264_abnormal_extraembryonic_tissu0.62556831
124MP0003221_abnormal_cardiomyocyte_apopto0.61780891
125MP0009250_abnormal_appendicular_skeleto0.61776925
126MP0005376_homeostasis/metabolism_phenot0.61008146
127MP0001485_abnormal_pinna_reflex0.60782154
128MP0009643_abnormal_urine_homeostasis0.60459277
129MP0005023_abnormal_wound_healing0.60433467
130MP0000647_abnormal_sebaceous_gland0.60251894
131MP0004233_abnormal_muscle_weight0.60212118
132MP0001968_abnormal_touch/_nociception0.60041040
133MP0003123_paternal_imprinting0.59909510
134MP0003137_abnormal_impulse_conducting0.59641528
135MP0009697_abnormal_copulation0.58553761
136MP0003115_abnormal_respiratory_system0.58410528
137MP0002098_abnormal_vibrissa_morphology0.58164328
138MP0002090_abnormal_vision0.57750694
139MP0004272_abnormal_basement_membrane0.57543043
140MP0005257_abnormal_intraocular_pressure0.56782306
141MP0005391_vision/eye_phenotype0.55929089
142MP0005379_endocrine/exocrine_gland_phen0.55122292
143MP0008057_abnormal_DNA_replication0.54927723
144* MP0000266_abnormal_heart_morphology0.54467460
145MP0001727_abnormal_embryo_implantation0.54365313
146* MP0002925_abnormal_cardiovascular_devel0.53835708
147MP0009763_increased_sensitivity_to0.53554880
148MP0000163_abnormal_cartilage_morphology0.53246481
149MP0008007_abnormal_cellular_replicative0.52668855
150MP0009703_decreased_birth_body0.52318180
151* MP0002081_perinatal_lethality0.50785366
152* MP0003385_abnormal_body_wall0.50343991
153MP0000604_amyloidosis0.49893194
154MP0002928_abnormal_bile_duct0.48755184
155* MP0002152_abnormal_brain_morphology0.46116708
156MP0001299_abnormal_eye_distance/0.46090073
157MP0000026_abnormal_inner_ear0.45362075

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.08913117
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.91715056
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.87168711
4Deep venous thrombosis (HP:0002625)5.69118465
5Hypobetalipoproteinemia (HP:0003563)5.65877486
6Abnormality of the fetal cardiovascular system (HP:0010948)5.51259584
7Abnormal umbilical cord blood vessels (HP:0011403)5.51259584
8Single umbilical artery (HP:0001195)5.51259584
9Back pain (HP:0003418)5.11460297
10Rib fusion (HP:0000902)4.68136338
11Xanthomatosis (HP:0000991)4.60064743
12Congenital malformation of the right heart (HP:0011723)4.53936427
13Double outlet right ventricle (HP:0001719)4.53936427
14Prolonged partial thromboplastin time (HP:0003645)4.30727365
15Abnormality of sulfur amino acid metabolism (HP:0004339)4.25009861
16Abnormality of pyrimidine metabolism (HP:0004353)4.17643720
17Complement deficiency (HP:0004431)4.13258989
18Short humerus (HP:0005792)4.13254964
19Hyperammonemia (HP:0001987)3.97802134
20Aplasia/Hypoplasia of the sacrum (HP:0008517)3.95003000
21Septo-optic dysplasia (HP:0100842)3.94783074
22Abnormal pancreas size (HP:0012094)3.94149634
23Abdominal situs inversus (HP:0003363)3.83539400
24Abnormality of abdominal situs (HP:0011620)3.83539400
25Periauricular skin pits (HP:0100277)3.78509054
26Preauricular pit (HP:0004467)3.78509054
27Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.73459071
28Abnormality of methionine metabolism (HP:0010901)3.70502040
29Hyperlipoproteinemia (HP:0010980)3.69295155
30Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.61891440
31Abnormality of the umbilical cord (HP:0010881)3.61436451
32Myelomeningocele (HP:0002475)3.55294995
33Transposition of the great arteries (HP:0001669)3.52307053
34Abnormal connection of the cardiac segments (HP:0011545)3.52307053
35Abnormal ventriculo-arterial connection (HP:0011563)3.52307053
36Hypolipoproteinemia (HP:0010981)3.51801418
37Ketosis (HP:0001946)3.51271685
38Short middle phalanx of the 5th finger (HP:0004220)3.49511937
39Abnormality of aspartate family amino acid metabolism (HP:0010899)3.36212464
40Epidermoid cyst (HP:0200040)3.34266065
41Hyperglycinemia (HP:0002154)3.33924332
42Abnormality of the common coagulation pathway (HP:0010990)3.32101309
43Abnormality of glycine metabolism (HP:0010895)3.32095232
44Abnormality of serine family amino acid metabolism (HP:0010894)3.32095232
45Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.29450984
46Abnormality of the phalanges of the 5th finger (HP:0004213)3.22679306
47Abnormality of glutamine family amino acid metabolism (HP:0010902)3.22426521
48Abnormality of the pancreatic islet cells (HP:0006476)3.20933299
49Abnormality of endocrine pancreas physiology (HP:0012093)3.20933299
50Late onset (HP:0003584)3.20377934
51Abnormality of the pubic bones (HP:0003172)3.18686858
52Bifid tongue (HP:0010297)3.16015320
53Preaxial foot polydactyly (HP:0001841)3.10042294
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.09968242
55Oligodactyly (hands) (HP:0001180)3.08813505
56Hyperglycinuria (HP:0003108)3.08059306
57Ketoacidosis (HP:0001993)3.07121201
58Abnormality of complement system (HP:0005339)3.05700318
59Anal stenosis (HP:0002025)3.01097514
60Fat malabsorption (HP:0002630)2.94877462
61Hypoglycemic coma (HP:0001325)2.87445811
62Anophthalmia (HP:0000528)2.82165173
63Spastic diplegia (HP:0001264)2.80722302
64Intestinal atresia (HP:0011100)2.76553047
65Hypoplastic pelvis (HP:0008839)2.76497090
66Delayed CNS myelination (HP:0002188)2.72250935
67Labial hypoplasia (HP:0000066)2.68880694
68Hypercholesterolemia (HP:0003124)2.65653487
69Hypoplastic female external genitalia (HP:0012815)2.64954010
70Oligodactyly (HP:0012165)2.61103139
71Shawl scrotum (HP:0000049)2.60464695
72Joint hemorrhage (HP:0005261)2.57783149
73Cortical dysplasia (HP:0002539)2.55492895
74Progressive external ophthalmoplegia (HP:0000590)2.55087301
75Mixed hearing impairment (HP:0000410)2.53998151
76Abnormality of the aortic arch (HP:0012303)2.52933618
77Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.51543383
78Pseudobulbar signs (HP:0002200)2.50515340
79Ectopic anus (HP:0004397)2.48458377
80Missing ribs (HP:0000921)2.47540607
81Absent forearm bone (HP:0003953)2.46612479
82Skin nodule (HP:0200036)2.45245263
83Abnormality of the middle phalanges of the toes (HP:0010183)2.44331331
84Abnormality of serum amino acid levels (HP:0003112)2.44127521
85Erectile abnormalities (HP:0100639)2.42384526
86Oral leukoplakia (HP:0002745)2.42083061
87Rectovaginal fistula (HP:0000143)2.41555440
88Rectal fistula (HP:0100590)2.41555440
89Abnormality of nucleobase metabolism (HP:0010932)2.41383191
90Abnormal lung lobation (HP:0002101)2.40411389
91Hemivertebrae (HP:0002937)2.38571378
92Skin pits (HP:0100276)2.38019542
93Short hallux (HP:0010109)2.37858774
94Gonadal dysgenesis (HP:0000133)2.36892783
95Hypoalphalipoproteinemia (HP:0003233)2.35135172
96Ureteral duplication (HP:0000073)2.34120829
97Hyperbilirubinemia (HP:0002904)2.30496778
98Volvulus (HP:0002580)2.28773550
99Vertebral fusion (HP:0002948)2.27203327
100Abnormality of the intrinsic pathway (HP:0010989)2.26208025
101Absent eyebrow (HP:0002223)2.25618068
102Abnormality of the parathyroid morphology (HP:0011766)2.23692015
103Hepatocellular carcinoma (HP:0001402)2.23501502
104Patent foramen ovale (HP:0001655)2.22705711
105Esophageal varix (HP:0002040)2.22259307
106Carpal bone hypoplasia (HP:0001498)2.22098152
107Aplasia/Hypoplasia of the hallux (HP:0008362)2.21250985
108Dicarboxylic aciduria (HP:0003215)2.17095543
109Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17095543
110Lethargy (HP:0001254)2.17068682
111Abnormality of the septum pellucidum (HP:0007375)2.14959238
112Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14080691
113Breast aplasia (HP:0100783)2.13475241
114Mesomelia (HP:0003027)2.12561726
115Hepatoblastoma (HP:0002884)2.12256970
116Absent septum pellucidum (HP:0001331)2.11508475
117Conjugated hyperbilirubinemia (HP:0002908)2.11293456
118Abnormalities of placenta or umbilical cord (HP:0001194)2.09864956
119Aplasia/Hypoplasia of the scapulae (HP:0006713)2.08892241
120Hypoplastic scapulae (HP:0000882)2.08892241
121Maternal diabetes (HP:0009800)2.08695375
122Stenosis of the external auditory canal (HP:0000402)2.08609038
123Abnormal vertebral ossification (HP:0100569)2.08343339
124Irritability (HP:0000737)2.07395869
125Aplasia/Hypoplasia of the spleen (HP:0010451)2.05854172
126Steatorrhea (HP:0002570)2.04686868
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04277049
128Increased serum pyruvate (HP:0003542)2.03793727
129Abnormality of glycolysis (HP:0004366)2.03793727
130Malnutrition (HP:0004395)2.03536715
131Absent toe (HP:0010760)2.03495145
132Aplasia/Hypoplasia of the uvula (HP:0010293)2.02488255
133Vaginal fistula (HP:0004320)2.00306136
134Preauricular skin tag (HP:0000384)1.99825539
135Irregular epiphyses (HP:0010582)1.97968334
136Intestinal fistula (HP:0100819)1.95382275
137Soft skin (HP:0000977)1.91980049
138Proximal tubulopathy (HP:0000114)1.91655551
139Megaloblastic anemia (HP:0001889)1.90902241
140Aplasia/Hypoplasia of the breasts (HP:0010311)1.90313422
141Neonatal onset (HP:0003623)1.89719573
142Anosmia (HP:0000458)1.89623008
143Primary amenorrhea (HP:0000786)1.88321879
144Aplasia/hypoplasia of the humerus (HP:0006507)1.87588470
145Abnormality of the humerus (HP:0003063)1.87099119
146Hypoglycemic seizures (HP:0002173)1.87009999
147Rhabdomyolysis (HP:0003201)1.86965107
148Premature rupture of membranes (HP:0001788)1.86019317
149Horseshoe kidney (HP:0000085)1.84082174
150Short middle phalanx of finger (HP:0005819)1.83123638
151Sprengel anomaly (HP:0000912)1.82993153
152Anal atresia (HP:0002023)1.82906303
153Abnormality of the upper arm (HP:0001454)1.82755246
154Abnormality of fatty-acid metabolism (HP:0004359)1.81343895
155Diastasis recti (HP:0001540)1.81069576
156Skin tags (HP:0010609)1.80559585
157Split foot (HP:0001839)1.79180905
158Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78886577
159Asplenia (HP:0001746)1.78562343
160Upper motor neuron abnormality (HP:0002127)1.78125229
161Fused cervical vertebrae (HP:0002949)1.77764610
162Gonadotropin excess (HP:0000837)1.77488777
163Optic nerve hypoplasia (HP:0000609)1.77475572
164Reticulocytosis (HP:0001923)1.77454398
165Abnormal cartilage morphology (HP:0002763)1.77254161
166Absent radius (HP:0003974)1.77127400
167Abnormality of the gallbladder (HP:0005264)1.76478721
168Abnormality of cochlea (HP:0000375)1.75136242
169Abnormal gallbladder morphology (HP:0012437)1.74715852
170Cholelithiasis (HP:0001081)1.73702396
171Aqueductal stenosis (HP:0002410)1.73184887
172Cerebral edema (HP:0002181)1.72951625
173Small epiphyses (HP:0010585)1.72642324
174Macrocytic anemia (HP:0001972)1.72339302
175Abnormality of reticulocytes (HP:0004312)1.71721391
176Enlarged kidneys (HP:0000105)1.70008701
177Pancreatic islet-cell hyperplasia (HP:0004510)1.68842929
178Proximal placement of thumb (HP:0009623)1.68047210
179Deviation of the thumb (HP:0009603)1.66337678
180High anterior hairline (HP:0009890)1.65953774
181Gout (HP:0001997)1.65295894
182Colon cancer (HP:0003003)1.65177956
183Vascular calcification (HP:0004934)1.64257060
184Confusion (HP:0001289)1.63420165
185Aplasia involving forearm bones (HP:0009822)1.63309683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS28.62974076
2CDK127.88682307
3BRD44.61906215
4PBK3.85562178
5ACVR1B3.44633653
6TRIM283.04379499
7TNIK2.86854124
8BCKDK2.71490690
9MAP3K92.65313748
10BMPR1B2.64380436
11ERN12.62047394
12MKNK22.57338655
13MST42.44132546
14SIK12.26526698
15BUB12.20936487
16PASK2.18090569
17TGFBR12.00866471
18WNK31.93421117
19MAP3K41.85871217
20BCR1.76267730
21TESK21.70555588
22PLK21.70246586
23CDC71.69712585
24PAK41.68148308
25EPHA41.64788122
26KDR1.59338261
27ERBB31.49252302
28MAP4K21.43705102
29CDK71.39715839
30TSSK61.39692916
31BRSK21.32294886
32EIF2AK31.30957002
33NUAK11.29884483
34MAP3K81.27983089
35MAP3K101.26345476
36EIF2AK11.23612440
37PLK41.21542937
38MAP2K71.20329511
39NEK11.18497577
40LATS11.14760908
41FGFR41.14204759
42SIK31.11624987
43TTK1.09698920
44VRK21.09153372
45CASK1.08378360
46WEE11.06691746
47ERBB41.01811022
48STK161.01468572
49CDK91.01456004
50NEK21.00146557
51ARAF0.99897030
52MTOR0.97347315
53ALK0.93964076
54ZAK0.92636140
55CDK60.91916965
56CAMK1D0.82070082
57PLK10.81779886
58MET0.80475424
59STK100.78899079
60VRK10.77928441
61CSNK1G10.76728163
62BRSK10.76544466
63EIF2AK20.75789328
64EEF2K0.74425373
65ICK0.73473316
66PDK20.72136013
67PLK30.72029811
68CSNK1G20.71405372
69MAP3K110.70470370
70PKN20.70415477
71KSR20.70228104
72RPS6KB20.70114976
73STK38L0.69893251
74PAK10.69742774
75CSNK1E0.69640143
76DAPK20.69549699
77GRK60.69267118
78STK40.69194611
79CHEK10.68241327
80DMPK0.67595166
81STK30.67501664
82MKNK10.66923667
83SCYL20.65113150
84TAF10.63396793
85CDK40.62396379
86SRPK10.62234332
87PTK60.62013619
88TLK10.61945373
89IRAK20.59812314
90FGFR10.58754359
91AURKA0.58194415
92PTK20.57444908
93MELK0.55614471
94TESK10.55028015
95ATR0.53134586
96CDK190.52942202
97TYRO30.50797627
98MAP2K30.50477479
99CHEK20.49054499
100AURKB0.48972851
101CSNK1G30.48291904
102CAMK1G0.47332178
103MOS0.46437594
104LRRK20.46341846
105ROCK20.45353696
106EPHA20.45289394
107NME10.42588574
108AKT20.40972510
109CDK20.40594073
110TIE10.40493056
111DYRK30.40371939
112NTRK10.38236882
113DYRK20.38031770
114CDK180.38031218
115ADRBK10.37162054
116ABL20.37093940
117CSNK2A20.36726266
118ATM0.36227751
119MATK0.35605725
120FLT30.35404414
121MAP3K30.35283818
122PRKD30.34837591
123DYRK1A0.33614273
124ERBB20.33603695
125MAP2K20.33033244
126KSR10.32270265
127PRKCI0.30717525
128ROCK10.29657181
129CDK10.29577672
130PRKD10.29174105
131MAPK110.28945994
132DYRK1B0.28668289
133CSNK2A10.27797777
134CDK11A0.26839514
135MAP2K40.26736128
136CDK150.26448081
137MST1R0.26396104
138STK390.26230944
139MINK10.26117480
140CDK140.26080937
141DAPK10.25382119
142PRKDC0.24000571
143PDGFRA0.22391813
144RPS6KA50.20767540
145TYK20.19180916
146MAPK10.18387952
147PAK20.16801367
148PNCK0.16335459
149BMX0.15839816
150TTN0.15738034
151NLK0.14577366
152PRKCZ0.14501780
153BRAF0.13959732
154RPS6KA40.13315135

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.74737638
2TGF-beta signaling pathway_Homo sapiens_hsa043503.72325296
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.61163590
4Nitrogen metabolism_Homo sapiens_hsa009103.20888492
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.97758330
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90685385
7One carbon pool by folate_Homo sapiens_hsa006702.85140207
8Arginine biosynthesis_Homo sapiens_hsa002202.84416478
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75336726
10Wnt signaling pathway_Homo sapiens_hsa043102.50401748
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.50069405
12Non-homologous end-joining_Homo sapiens_hsa034502.38406315
13Protein export_Homo sapiens_hsa030602.26947327
14Tryptophan metabolism_Homo sapiens_hsa003802.23282021
15Biosynthesis of amino acids_Homo sapiens_hsa012302.09515118
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08085233
17Selenocompound metabolism_Homo sapiens_hsa004502.07492665
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.06883524
19Complement and coagulation cascades_Homo sapiens_hsa046102.06174244
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95695061
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95622882
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.95000595
23Fatty acid degradation_Homo sapiens_hsa000711.85591425
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73205825
25Basal transcription factors_Homo sapiens_hsa030221.71939742
26Fanconi anemia pathway_Homo sapiens_hsa034601.70465126
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.69826917
28Butanoate metabolism_Homo sapiens_hsa006501.61703254
29Histidine metabolism_Homo sapiens_hsa003401.61455999
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60480383
31Carbon metabolism_Homo sapiens_hsa012001.57889580
32* Retinol metabolism_Homo sapiens_hsa008301.57653446
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57411701
34Pyruvate metabolism_Homo sapiens_hsa006201.55678895
35Phenylalanine metabolism_Homo sapiens_hsa003601.55568801
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55534180
37Propanoate metabolism_Homo sapiens_hsa006401.54988357
38Chemical carcinogenesis_Homo sapiens_hsa052041.44956410
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44266217
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40011559
41Peroxisome_Homo sapiens_hsa041461.39502064
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39373367
43DNA replication_Homo sapiens_hsa030301.35811139
44Fatty acid metabolism_Homo sapiens_hsa012121.34721376
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32182675
46beta-Alanine metabolism_Homo sapiens_hsa004101.29918722
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.29380123
48Steroid biosynthesis_Homo sapiens_hsa001001.28591779
49Tyrosine metabolism_Homo sapiens_hsa003501.27416613
50Folate biosynthesis_Homo sapiens_hsa007901.26051984
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25428110
52PPAR signaling pathway_Homo sapiens_hsa033201.19911513
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19338300
54Mismatch repair_Homo sapiens_hsa034301.17908947
55Staphylococcus aureus infection_Homo sapiens_hsa051501.15405558
56Fat digestion and absorption_Homo sapiens_hsa049751.11964340
57Bile secretion_Homo sapiens_hsa049761.11097881
58Spliceosome_Homo sapiens_hsa030401.10645867
59Ribosome_Homo sapiens_hsa030101.08671705
60Caffeine metabolism_Homo sapiens_hsa002321.08011673
61Vitamin B6 metabolism_Homo sapiens_hsa007501.02713276
62Arginine and proline metabolism_Homo sapiens_hsa003301.02684286
63Parkinsons disease_Homo sapiens_hsa050121.01127576
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00700341
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00330964
66Proteasome_Homo sapiens_hsa030500.95914758
67RNA transport_Homo sapiens_hsa030130.94383455
68RNA polymerase_Homo sapiens_hsa030200.94265764
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.93720247
70Melanogenesis_Homo sapiens_hsa049160.90417940
71Lysine degradation_Homo sapiens_hsa003100.86427174
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84915529
73Pyrimidine metabolism_Homo sapiens_hsa002400.82064395
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80554164
75Tight junction_Homo sapiens_hsa045300.80053635
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76825421
77Glutathione metabolism_Homo sapiens_hsa004800.76608425
78Protein digestion and absorption_Homo sapiens_hsa049740.75925885
79Colorectal cancer_Homo sapiens_hsa052100.75048395
80Starch and sucrose metabolism_Homo sapiens_hsa005000.74716386
81Oxidative phosphorylation_Homo sapiens_hsa001900.71188570
82Huntingtons disease_Homo sapiens_hsa050160.69985384
83Fatty acid elongation_Homo sapiens_hsa000620.69528937
84Pentose phosphate pathway_Homo sapiens_hsa000300.67617699
85Thyroid cancer_Homo sapiens_hsa052160.66199029
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66178462
87Basal cell carcinoma_Homo sapiens_hsa052170.65392640
88Sulfur metabolism_Homo sapiens_hsa009200.64689068
89Pathways in cancer_Homo sapiens_hsa052000.64655438
90Prion diseases_Homo sapiens_hsa050200.62932719
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60298674
92ECM-receptor interaction_Homo sapiens_hsa045120.58641126
93ABC transporters_Homo sapiens_hsa020100.58070035
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55746819
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55154136
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53554573
97Systemic lupus erythematosus_Homo sapiens_hsa053220.52580983
98N-Glycan biosynthesis_Homo sapiens_hsa005100.52397686
99Phototransduction_Homo sapiens_hsa047440.50053636
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49976448
101Nucleotide excision repair_Homo sapiens_hsa034200.49274378
102Base excision repair_Homo sapiens_hsa034100.48939112
103Sulfur relay system_Homo sapiens_hsa041220.48208773
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47124882
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46549931
106Axon guidance_Homo sapiens_hsa043600.44091495
107Glycerolipid metabolism_Homo sapiens_hsa005610.42837613
108Rap1 signaling pathway_Homo sapiens_hsa040150.42689987
109Olfactory transduction_Homo sapiens_hsa047400.42661763
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41911952
111Vitamin digestion and absorption_Homo sapiens_hsa049770.41739133
112* Metabolic pathways_Homo sapiens_hsa011000.41675949
113Purine metabolism_Homo sapiens_hsa002300.41266306
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40364290
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35569005
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34311863
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33753791
118Hedgehog signaling pathway_Homo sapiens_hsa043400.31976198
119Fatty acid biosynthesis_Homo sapiens_hsa000610.31243867
120MicroRNAs in cancer_Homo sapiens_hsa052060.30410198
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.30330773
122Proteoglycans in cancer_Homo sapiens_hsa052050.29728962
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28867748
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28629381
125Glucagon signaling pathway_Homo sapiens_hsa049220.26720326
126Adherens junction_Homo sapiens_hsa045200.25736297
127Insulin resistance_Homo sapiens_hsa049310.25274856
128Nicotine addiction_Homo sapiens_hsa050330.23847971
129Cell cycle_Homo sapiens_hsa041100.22972995
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21707532
131Melanoma_Homo sapiens_hsa052180.21618684
132Hippo signaling pathway_Homo sapiens_hsa043900.17410070
133Homologous recombination_Homo sapiens_hsa034400.16493238
134p53 signaling pathway_Homo sapiens_hsa041150.15106726
135Galactose metabolism_Homo sapiens_hsa000520.15080674
136mRNA surveillance pathway_Homo sapiens_hsa030150.11269199
137RNA degradation_Homo sapiens_hsa030180.08934907
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08759125
139Oocyte meiosis_Homo sapiens_hsa041140.07026501
140Bladder cancer_Homo sapiens_hsa052190.06166232

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