CYP24A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)9.97985310
2detection of temperature stimulus involved in sensory perception of pain (GO:0050965)9.66608932
3detection of temperature stimulus involved in sensory perception (GO:0050961)9.66608932
4aminoglycoside antibiotic metabolic process (GO:0030647)9.51070924
5drug transport (GO:0015893)8.38531194
6cell adhesion mediated by integrin (GO:0033627)8.13143016
7phosphate ion transport (GO:0006817)7.91014672
8neuronal stem cell maintenance (GO:0097150)7.74763306
9organic cation transport (GO:0015695)7.58227679
10lysine catabolic process (GO:0006554)7.48558699
11lysine metabolic process (GO:0006553)7.48558699
12detection of temperature stimulus (GO:0016048)6.80506801
13quaternary ammonium group transport (GO:0015697)6.73592999
14phosphate ion transmembrane transport (GO:0035435)6.66060195
15glyoxylate metabolic process (GO:0046487)6.58920295
16drug catabolic process (GO:0042737)6.33657427
17exogenous drug catabolic process (GO:0042738)6.18781834
18cysteine metabolic process (GO:0006534)6.06086651
19excretion (GO:0007588)6.04309513
20primary alcohol catabolic process (GO:0034310)5.81814349
21response to mercury ion (GO:0046689)5.81201512
22tricarboxylic acid metabolic process (GO:0072350)5.67193041
23hemidesmosome assembly (GO:0031581)5.40663747
24short-chain fatty acid metabolic process (GO:0046459)5.35666468
25homocysteine metabolic process (GO:0050667)5.31275568
26nonribosomal peptide biosynthetic process (GO:0019184)5.30190271
27metanephric nephron tubule development (GO:0072234)5.25510704
28metanephric tubule development (GO:0072170)5.25510704
29trivalent inorganic anion homeostasis (GO:0072506)5.24417528
30phosphate ion homeostasis (GO:0055062)5.24417528
31renal absorption (GO:0070293)5.08684007
32aspartate family amino acid catabolic process (GO:0009068)5.03996479
33response to parathyroid hormone (GO:0071107)4.95375709
34carnitine transport (GO:0015879)4.88098341
35amino-acid betaine transport (GO:0015838)4.88098341
36metanephric nephron epithelium development (GO:0072243)4.88069995
37glutathione biosynthetic process (GO:0006750)4.80005057
38modified amino acid transport (GO:0072337)4.79591893
39toxin transport (GO:1901998)4.77436636
40sulfate transmembrane transport (GO:1902358)4.76504077
41L-phenylalanine metabolic process (GO:0006558)4.62435365
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.62435365
43proline metabolic process (GO:0006560)4.60762249
44protein hydroxylation (GO:0018126)4.53863047
45paraxial mesoderm development (GO:0048339)4.51365867
46metanephric epithelium development (GO:0072207)4.50583377
47plasma membrane repair (GO:0001778)4.40200917
48inner ear receptor cell development (GO:0060119)4.38120527
49branched-chain amino acid metabolic process (GO:0009081)4.35434295
50* vitamin D metabolic process (GO:0042359)4.34512166
51cellular modified amino acid catabolic process (GO:0042219)4.21214770
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.20321491
53L-phenylalanine catabolic process (GO:0006559)4.20321491
54glycoside metabolic process (GO:0016137)4.20284263
55serine family amino acid catabolic process (GO:0009071)4.16761043
56sulfur compound transport (GO:0072348)4.15025669
57membrane raft organization (GO:0031579)4.14887706
58serine family amino acid metabolic process (GO:0009069)4.13266117
59nephron tubule development (GO:0072080)4.12239697
60valine metabolic process (GO:0006573)4.09810846
61pentose-phosphate shunt (GO:0006098)4.05829955
62dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.05825782
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.03457364
64nucleobase-containing small molecule interconversion (GO:0015949)3.97815702
65amino-acid betaine metabolic process (GO:0006577)3.96137660
66regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.94894178
67fatty acid beta-oxidation (GO:0006635)3.94055408
68mesodermal cell differentiation (GO:0048333)3.93829897
69peptide biosynthetic process (GO:0043043)3.89498893
70mammary gland development (GO:0030879)3.89378147
71branching involved in salivary gland morphogenesis (GO:0060445)3.84658551
72aromatic amino acid family catabolic process (GO:0009074)3.83485589
73sulfate transport (GO:0008272)3.82355667
74progesterone metabolic process (GO:0042448)3.79240291
75lung vasculature development (GO:0060426)3.74929042
76fructose metabolic process (GO:0006000)3.74151641
77acetyl-CoA metabolic process (GO:0006084)3.71246995
78glutathione derivative biosynthetic process (GO:1901687)3.69817806
79glutathione derivative metabolic process (GO:1901685)3.69817806
802-oxoglutarate metabolic process (GO:0006103)3.69710753
81response to growth hormone (GO:0060416)3.66891662
82glutamate metabolic process (GO:0006536)3.66005259
83NADPH regeneration (GO:0006740)3.64844973
84NADH metabolic process (GO:0006734)3.64255011
85vitamin transport (GO:0051180)3.59877181
86renal tubule development (GO:0061326)3.59520863
87nuclear pore complex assembly (GO:0051292)3.58421912
88fatty acid oxidation (GO:0019395)3.57822938
89glutathione metabolic process (GO:0006749)3.54095084
90sodium-independent organic anion transport (GO:0043252)3.51880152
91tryptophan catabolic process (GO:0006569)3.51746391
92indole-containing compound catabolic process (GO:0042436)3.51746391
93indolalkylamine catabolic process (GO:0046218)3.51746391
94lipid oxidation (GO:0034440)3.50045153
95carnitine metabolic process (GO:0009437)3.48635587
96peptidyl-proline hydroxylation (GO:0019511)3.48286140
97positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.47664719
98nephron tubule morphogenesis (GO:0072078)3.46209172
99nephron epithelium morphogenesis (GO:0072088)3.46209172
100tryptophan metabolic process (GO:0006568)3.46052601
101mesenchymal-epithelial cell signaling (GO:0060638)3.45671346
102polyol transport (GO:0015791)3.45663123
103positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.43824059
104glucose catabolic process (GO:0006007)3.43462770
105regulation of glucose import in response to insulin stimulus (GO:2001273)3.42516833
106regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.38740011
107peptide catabolic process (GO:0043171)3.37019015
108uronic acid metabolic process (GO:0006063)3.36582586
109glucuronate metabolic process (GO:0019585)3.36582586
110desmosome organization (GO:0002934)3.36331987
111response to magnesium ion (GO:0032026)3.35473384
112branched-chain amino acid catabolic process (GO:0009083)3.34515134
113NADP metabolic process (GO:0006739)3.33602511
114histamine transport (GO:0051608)3.33579304
115nephron epithelium development (GO:0072009)3.32945059
116positive regulation of endothelial cell apoptotic process (GO:2000353)3.31177461
117membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.28989738
118flavonoid metabolic process (GO:0009812)3.28838011
119sodium ion transport (GO:0006814)3.27550093
120ethanol oxidation (GO:0006069)3.27514337
121membrane protein ectodomain proteolysis (GO:0006509)3.27344897
122positive regulation of keratinocyte differentiation (GO:0045618)3.27184943
123response to laminar fluid shear stress (GO:0034616)3.26882242
124positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.26849711
125regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.26849711
126cellular amino acid catabolic process (GO:0009063)3.23576050
127fatty acid catabolic process (GO:0009062)3.23335250
128skin morphogenesis (GO:0043589)3.23264967
129cellular ketone body metabolic process (GO:0046950)3.23243718
130positive regulation of digestive system process (GO:0060456)3.22199848
131alpha-amino acid catabolic process (GO:1901606)3.19313251
132glomerular visceral epithelial cell development (GO:0072015)3.18656337
133cobalamin metabolic process (GO:0009235)3.17296465
134notochord development (GO:0030903)3.16468945
135pyrimidine ribonucleoside catabolic process (GO:0046133)3.15930597
136substrate-dependent cell migration (GO:0006929)3.15124088
137regulation of apoptotic process involved in morphogenesis (GO:1902337)3.14890365
138ethanol metabolic process (GO:0006067)3.13126061
139aldehyde catabolic process (GO:0046185)3.12912536
140glutamine family amino acid catabolic process (GO:0009065)3.12761267
141drug metabolic process (GO:0017144)3.12708977
142negative regulation of anoikis (GO:2000811)3.12026679
143cellular aldehyde metabolic process (GO:0006081)3.11653567
144dicarboxylic acid biosynthetic process (GO:0043650)3.11628823
145lung epithelium development (GO:0060428)3.02930710
146epithelial cell-cell adhesion (GO:0090136)3.02142185
147negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.00839884
148C21-steroid hormone metabolic process (GO:0008207)2.99088466
149protein localization to microtubule (GO:0035372)2.99072838
150positive regulation of actin filament depolymerization (GO:0030836)2.97590658
151thrombin receptor signaling pathway (GO:0070493)2.95403882
152retinal metabolic process (GO:0042574)2.94551828
153negative regulation of chondrocyte differentiation (GO:0032331)2.92417677
154regulation of hippo signaling (GO:0035330)2.91941316
155cell-substrate junction assembly (GO:0007044)2.90799279
156regulation of immune response to tumor cell (GO:0002837)2.89108670
157regulation of response to tumor cell (GO:0002834)2.89108670
158positive regulation of response to tumor cell (GO:0002836)2.89108670
159positive regulation of immune response to tumor cell (GO:0002839)2.89108670
160regulation of glomerular filtration (GO:0003093)2.84057115
161glucose 6-phosphate metabolic process (GO:0051156)2.82586088
162mitotic chromosome condensation (GO:0007076)2.81376926
163glomerular epithelial cell development (GO:0072310)2.80678747
164regulation of membrane protein ectodomain proteolysis (GO:0051043)2.79428624
165regulation of mitotic spindle organization (GO:0060236)2.78209911
166nuclear pore organization (GO:0006999)2.77820255
167hepatocyte differentiation (GO:0070365)2.76179166
168positive regulation of epidermal cell differentiation (GO:0045606)2.73175459
169stress fiber assembly (GO:0043149)2.72339889
170positive regulation of extracellular matrix organization (GO:1903055)2.71629170
171cyclooxygenase pathway (GO:0019371)2.71423271
172regulation of superoxide anion generation (GO:0032928)2.70697979
173prostaglandin metabolic process (GO:0006693)2.69498932
174prostanoid metabolic process (GO:0006692)2.69498932
175regulation of transforming growth factor beta2 production (GO:0032909)2.66971540
176extracellular matrix assembly (GO:0085029)2.65572951
177cellular protein complex localization (GO:0034629)2.65509552
178activation of NF-kappaB-inducing kinase activity (GO:0007250)2.64554060
179glomerular basement membrane development (GO:0032836)2.63169802
180pentose metabolic process (GO:0019321)2.62650828
181regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.57426408
182pore complex assembly (GO:0046931)2.57378803
183negative regulation of homotypic cell-cell adhesion (GO:0034111)2.56998652
184activation of Rac GTPase activity (GO:0032863)2.55346805
185hippo signaling (GO:0035329)2.53782871
186nephron tubule formation (GO:0072079)2.53181829
187COPI coating of Golgi vesicle (GO:0048205)2.51045948
188Golgi transport vesicle coating (GO:0048200)2.51045948
189positive regulation of Rho protein signal transduction (GO:0035025)2.47239739
190regulation of keratinocyte differentiation (GO:0045616)2.45529786
191endothelial cell morphogenesis (GO:0001886)2.45095665
192daunorubicin metabolic process (GO:0044597)10.2667246
193polyketide metabolic process (GO:0030638)10.2667246
194doxorubicin metabolic process (GO:0044598)10.2667246
195drug transmembrane transport (GO:0006855)10.0478118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.41141694
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.21942229
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.54997303
4ZNF263_19887448_ChIP-Seq_K562_Human4.33128803
5RXR_22158963_ChIP-Seq_LIVER_Mouse4.20577740
6ESR1_21235772_ChIP-Seq_MCF-7_Human4.18625824
7FOXM1_23109430_ChIP-Seq_U2OS_Human4.09273926
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.45566244
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.41512052
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.36458268
11E2F7_22180533_ChIP-Seq_HELA_Human3.26286379
12LXR_22158963_ChIP-Seq_LIVER_Mouse3.20041315
13TRIM28_21343339_ChIP-Seq_HEK293_Human3.10233849
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96014537
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.76622812
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.76622812
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.63912858
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.55437932
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.50775757
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46705462
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.37016258
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19915956
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.15393255
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13393138
25ATF3_27146783_Chip-Seq_COLON_Human2.07988405
26HIF1A_21447827_ChIP-Seq_MCF-7_Human2.06210540
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06164163
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05078791
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97638691
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.97300359
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.95510726
32AR_21909140_ChIP-Seq_LNCAP_Human1.94294329
33TP53_22127205_ChIP-Seq_IMR90_Human1.92326617
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88630317
35CLOCK_20551151_ChIP-Seq_293T_Human1.86729486
36GATA4_25053715_ChIP-Seq_YYC3_Human1.85880413
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84200440
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82999610
39CTNNB1_20460455_ChIP-Seq_HCT116_Human1.82778166
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.78891436
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74149286
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72307696
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69753905
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68287907
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64925679
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64496083
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64442222
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.64081546
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63187454
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.55392177
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54819782
52JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54008285
53BRD4_25478319_ChIP-Seq_HGPS_Human1.50922055
54TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.49842625
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46614595
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.45986464
57HNF4A_19822575_ChIP-Seq_HepG2_Human1.44611249
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40167300
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38579996
60* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38314729
61* FOXO3_23340844_ChIP-Seq_DLD1_Human1.36560536
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36057027
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35548427
64GATA6_25053715_ChIP-Seq_YYC3_Human1.33375933
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32858520
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31392792
67* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28226969
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27980582
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27711385
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25866508
71* SMAD3_21741376_ChIP-Seq_HESCs_Human1.25787423
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25340160
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24622108
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.23490175
75SOX2_20726797_ChIP-Seq_SW620_Human1.22067029
76NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21008154
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.20524511
78RACK7_27058665_Chip-Seq_MCF-7_Human1.19865061
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.19152988
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19102551
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17844279
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17501769
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17100353
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.16699071
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14721063
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.14640763
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13581674
88* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11983783
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11607084
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09471259
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09002462
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07963908
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07906875
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07858806
95RXR_22108803_ChIP-Seq_LS180_Human1.06157826
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05648668
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04947457
98WDR5_24793694_ChIP-Seq_LNCAP_Human1.04265769
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.04039480
100TP53_18474530_ChIP-ChIP_U2OS_Human1.03528254
101CDX2_22108803_ChIP-Seq_LS180_Human1.03369052
102* SMAD4_21741376_ChIP-Seq_HESCs_Human1.02832487
103CJUN_26792858_Chip-Seq_BT549_Human1.02172674
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.01513895
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01373035
106LXR_22292898_ChIP-Seq_THP-1_Human1.01328323
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99548136
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99246776
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96404302
110FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95817246
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95369659
112* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94971506
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94411462
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94317611
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92342100
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92267216
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.91134502
118E2F1_21310950_ChIP-Seq_MCF-7_Human0.91070902
119TP63_23658742_ChIP-Seq_EP156T_Human0.90347944
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90270228
121KLF5_25053715_ChIP-Seq_YYC3_Human0.89769816
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89672056
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88171853
124AHR_22903824_ChIP-Seq_MCF-7_Human0.88060520
125GATA3_24758297_ChIP-Seq_MCF-7_Human0.88032533
126DCP1A_22483619_ChIP-Seq_HELA_Human0.87768460
127EP300_21415370_ChIP-Seq_HL-1_Mouse0.87426415
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.86413994
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.86413994
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85770768
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84928120
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84028655
133EGR1_19032775_ChIP-ChIP_M12_Human0.82965642
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.82865089
135VDR_24787735_ChIP-Seq_THP-1_Human0.82851743
136TCF4_22108803_ChIP-Seq_LS180_Human0.82732046
137* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81779477
138Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81159785
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79989657
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79704713
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79469081
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79446264
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76414471
144* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74805422
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.73488927
146MYC_19915707_ChIP-ChIP_AK7_Human0.72018029
147BCAT_22108803_ChIP-Seq_LS180_Human0.71987687
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71767249
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71767249
150* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.71159201
151BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70750179
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70184057
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69916988
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69508109
155* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.69284463
156CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69218591
157GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69128104
158WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.69021116
159FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.69004459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.25663553
2MP0004043_abnormal_pH_regulation6.11156197
3MP0003195_calcinosis4.85317161
4* MP0004019_abnormal_vitamin_homeostasis4.64265092
5MP0002138_abnormal_hepatobiliary_system4.59619883
6MP0002139_abnormal_hepatobiliary_system4.54438440
7MP0005332_abnormal_amino_acid4.46110164
8MP0002736_abnormal_nociception_after4.30336979
9* MP0009643_abnormal_urine_homeostasis3.90842084
10* MP0001765_abnormal_ion_homeostasis3.72760041
11MP0003950_abnormal_plasma_membrane3.60944769
12MP0005248_abnormal_Harderian_gland3.58776500
13MP0005365_abnormal_bile_salt3.25276965
14MP0001756_abnormal_urination3.23833241
15* MP0005636_abnormal_mineral_homeostasis3.13436836
16* MP0002136_abnormal_kidney_physiology3.00211869
17MP0003252_abnormal_bile_duct2.93434714
18MP0002877_abnormal_melanocyte_morpholog2.92606235
19MP0005076_abnormal_cell_differentiation2.89229076
20MP0004858_abnormal_nervous_system2.88274997
21MP0001958_emphysema2.68409224
22MP0003300_gastrointestinal_ulcer2.51295426
23MP0008875_abnormal_xenobiotic_pharmacok2.36874749
24MP0010352_gastrointestinal_tract_polyps2.36810383
25MP0005085_abnormal_gallbladder_physiolo2.29169118
26MP0005377_hearing/vestibular/ear_phenot2.24760467
27MP0003878_abnormal_ear_physiology2.24760467
28MP0001968_abnormal_touch/_nociception2.22290635
29MP0003705_abnormal_hypodermis_morpholog2.16311689
30MP0001849_ear_inflammation2.10582386
31MP0000579_abnormal_nail_morphology2.08449190
32MP0001348_abnormal_lacrimal_gland2.07367536
33MP0010234_abnormal_vibrissa_follicle2.01853349
34MP0005623_abnormal_meninges_morphology1.98535825
35MP0003091_abnormal_cell_migration1.97806507
36MP0004185_abnormal_adipocyte_glucose1.83680999
37MP0000383_abnormal_hair_follicle1.82685652
38MP0005058_abnormal_lysosome_morphology1.81729619
39MP0003453_abnormal_keratinocyte_physiol1.80479870
40MP0002928_abnormal_bile_duct1.80007349
41MP0000538_abnormal_urinary_bladder1.76704156
42MP0005409_darkened_coat_color1.67837020
43MP0005584_abnormal_enzyme/coenzyme_acti1.63320579
44MP0010678_abnormal_skin_adnexa1.62039248
45MP0005023_abnormal_wound_healing1.58102661
46MP0005451_abnormal_body_composition1.57595689
47MP0005257_abnormal_intraocular_pressure1.57242771
48MP0003186_abnormal_redox_activity1.55639429
49MP0002168_other_aberrant_phenotype1.53253834
50MP0008961_abnormal_basal_metabolism1.51344517
51MP0000627_abnormal_mammary_gland1.49931025
52MP0004885_abnormal_endolymph1.48689844
53MP0000537_abnormal_urethra_morphology1.48681798
54MP0009053_abnormal_anal_canal1.44452470
55MP0010771_integument_phenotype1.42510567
56MP0008932_abnormal_embryonic_tissue1.35894936
57MP0004957_abnormal_blastocyst_morpholog1.30570294
58MP0006036_abnormal_mitochondrial_physio1.27713126
59MP0004264_abnormal_extraembryonic_tissu1.26619023
60MP0002896_abnormal_bone_mineralization1.23877477
61MP0005084_abnormal_gallbladder_morpholo1.19511194
62MP0000230_abnormal_systemic_arterial1.19139199
63MP0002233_abnormal_nose_morphology1.16578031
64MP0004233_abnormal_muscle_weight1.15869602
65MP0003806_abnormal_nucleotide_metabolis1.15336907
66MP0001299_abnormal_eye_distance/1.14860720
67MP0004484_altered_response_of1.12834190
68MP0005319_abnormal_enzyme/_coenzyme1.07974872
69MP0000467_abnormal_esophagus_morphology1.06693471
70MP0002060_abnormal_skin_morphology1.06330325
71MP0010386_abnormal_urinary_bladder1.04811613
72MP0002234_abnormal_pharynx_morphology1.04264224
73MP0005666_abnormal_adipose_tissue1.03552924
74MP0000013_abnormal_adipose_tissue1.03422565
75MP0000733_abnormal_muscle_development1.01701144
76MP0006138_congestive_heart_failure1.00535298
77* MP0002135_abnormal_kidney_morphology0.98870328
78MP0001661_extended_life_span0.98029062
79MP0005670_abnormal_white_adipose0.97346296
80MP0003283_abnormal_digestive_organ0.96702096
81MP0004147_increased_porphyrin_level0.96394045
82MP0002006_tumorigenesis0.96292794
83MP0000858_altered_metastatic_potential0.96243683
84MP0003941_abnormal_skin_development0.96190823
85MP0001216_abnormal_epidermal_layer0.94184154
86MP0003937_abnormal_limbs/digits/tail_de0.94154702
87MP0001873_stomach_inflammation0.93279724
88MP0002822_catalepsy0.91758454
89MP0002332_abnormal_exercise_endurance0.91640633
90MP0002796_impaired_skin_barrier0.91197407
91MP0005165_increased_susceptibility_to0.88400203
92MP0005193_abnormal_anterior_eye0.88221843
93MP0001730_embryonic_growth_arrest0.88033081
94MP0002697_abnormal_eye_size0.87240187
95MP0005220_abnormal_exocrine_pancreas0.86720331
96MP0000350_abnormal_cell_proliferation0.85776730
97MP0001666_abnormal_nutrient_absorption0.85000821
98MP0001485_abnormal_pinna_reflex0.84637673
99MP0000490_abnormal_crypts_of0.83290184
100MP0005621_abnormal_cell_physiology0.82416935
101MP0002086_abnormal_extraembryonic_tissu0.82070289
102MP0003191_abnormal_cellular_cholesterol0.81378775
103MP0005501_abnormal_skin_physiology0.80162649
104MP0003755_abnormal_palate_morphology0.80126710
105MP0003111_abnormal_nucleus_morphology0.79252586
106MP0009764_decreased_sensitivity_to0.79035336
107MP0004782_abnormal_surfactant_physiolog0.78653413
108MP0004197_abnormal_fetal_growth/weight/0.78152451
109MP0005535_abnormal_body_temperature0.78091100
110MP0005395_other_phenotype0.77679059
111MP0002089_abnormal_postnatal_growth/wei0.76646281
112MP0003077_abnormal_cell_cycle0.75940019
113MP0005164_abnormal_response_to0.75638686
114MP0002118_abnormal_lipid_homeostasis0.75623692
115MP0002876_abnormal_thyroid_physiology0.74895128
116MP0001340_abnormal_eyelid_morphology0.74079148
117MP0001881_abnormal_mammary_gland0.73658723
118MP0002092_abnormal_eye_morphology0.72223151
119MP0002084_abnormal_developmental_patter0.72220574
120MP0003638_abnormal_response/metabolism_0.71525346
121MP0003984_embryonic_growth_retardation0.71331722
122MP0001286_abnormal_eye_development0.70690640
123MP0004272_abnormal_basement_membrane0.70209961
124MP0000534_abnormal_ureter_morphology0.70142993
125MP0010307_abnormal_tumor_latency0.69605208
126MP0001764_abnormal_homeostasis0.68413368
127MP0001915_intracranial_hemorrhage0.67484178
128MP0003935_abnormal_craniofacial_develop0.66884391
129MP0001672_abnormal_embryogenesis/_devel0.66409691
130MP0005380_embryogenesis_phenotype0.66409691
131MP0000428_abnormal_craniofacial_morphol0.65762678
132* MP0009642_abnormal_blood_homeostasis0.65323805
133MP0001697_abnormal_embryo_size0.64518670
134MP0002734_abnormal_mechanical_nocicepti0.64221954
135MP0002088_abnormal_embryonic_growth/wei0.63465252
136MP0003936_abnormal_reproductive_system0.63369634
137MP0008438_abnormal_cutaneous_collagen0.62377116
138MP0001663_abnormal_digestive_system0.62351449
139MP0002177_abnormal_outer_ear0.61956871
140MP0002098_abnormal_vibrissa_morphology0.61932170
141MP0003868_abnormal_feces_composition0.60092096
142MP0000747_muscle_weakness0.57309774
143MP0000609_abnormal_liver_physiology0.51586270
144MP0003566_abnormal_cell_adhesion0.51046269
145MP0002115_abnormal_skeleton_extremities0.50578091
146MP0009278_abnormal_bone_marrow0.50396086
147MP0003315_abnormal_perineum_morphology0.49110057
148MP0005375_adipose_tissue_phenotype0.48994456
149MP0003045_fibrosis0.48547959
150MP0008004_abnormal_stomach_pH0.48077647
151MP0005166_decreased_susceptibility_to0.46132110
152MP0005381_digestive/alimentary_phenotyp0.46018147
153MP0000598_abnormal_liver_morphology0.45709108
154MP0002998_abnormal_bone_remodeling0.45320688
155MP0001664_abnormal_digestion0.43644891
156MP0005595_abnormal_vascular_smooth0.43543921
157MP0010329_abnormal_lipoprotein_level0.43228083
158MP0004742_abnormal_vestibular_system0.43084707
159MP0003959_abnormal_lean_body0.42941470
160MP0003879_abnormal_hair_cell0.42896028
161MP0003795_abnormal_bone_structure0.42229768
162MP0003953_abnormal_hormone_level0.40750189
163MP0005408_hypopigmentation0.40732154
164MP0000762_abnormal_tongue_morphology0.40675623
165MP0000163_abnormal_cartilage_morphology0.39897137
166MP0001177_atelectasis0.38051132
167MP0008469_abnormal_protein_level0.37920104
168MP0005620_abnormal_muscle_contractility0.36873379
169MP0003172_abnormal_lysosome_physiology0.36298336
170MP0002078_abnormal_glucose_homeostasis0.35584388
171MP0003221_abnormal_cardiomyocyte_apopto0.35498689
172MP0009780_abnormal_chondrocyte_physiolo0.34353626
173MP0002735_abnormal_chemical_nociception0.33521562
174MP0005167_abnormal_blood-brain_barrier0.32939295
175MP0000377_abnormal_hair_follicle0.32711730
176MP0000678_abnormal_parathyroid_gland0.31818135
177MP0002972_abnormal_cardiac_muscle0.30708138

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.81730360
2Metabolic alkalosis (HP:0200114)7.22684689
3Hypokalemic alkalosis (HP:0001949)7.20738490
4Gout (HP:0001997)7.10312740
5Hyperactive renin-angiotensin system (HP:0000841)6.73475750
6Hypomagnesemia (HP:0002917)6.41040206
7Abnormality of chloride homeostasis (HP:0011422)6.29467586
8* Polyuria (HP:0000103)6.14108510
9* Abnormal urine output (HP:0012590)5.68508492
10* Abnormality of renal excretion (HP:0011036)5.51713705
11Abnormality of magnesium homeostasis (HP:0004921)5.45791684
12Proximal tubulopathy (HP:0000114)5.43099066
13Polydipsia (HP:0001959)5.23097523
14Abnormal drinking behavior (HP:0030082)5.23097523
15Hyperuricemia (HP:0002149)5.04478313
16Increased purine levels (HP:0004368)5.04478313
17Abnormality of renin-angiotensin system (HP:0000847)4.86329549
18Alkalosis (HP:0001948)4.84557228
19Tetany (HP:0001281)4.82684306
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.77499519
21Selective tooth agenesis (HP:0001592)4.75140617
22Abnormality of purine metabolism (HP:0004352)4.57354002
23Bronchomalacia (HP:0002780)4.47049602
24Renal salt wasting (HP:0000127)4.43507848
25Hyperaldosteronism (HP:0000859)4.36738499
26Hyperglycinuria (HP:0003108)4.16949225
27Broad face (HP:0000283)4.08314660
28Arterial tortuosity (HP:0005116)3.97902690
29* Hypercalciuria (HP:0002150)3.89510956
30Abnormality of urine glucose concentration (HP:0011016)3.85819271
31Glycosuria (HP:0003076)3.85819271
32Generalized aminoaciduria (HP:0002909)3.84829012
33Hypokalemia (HP:0002900)3.61465750
34Renal tubular acidosis (HP:0001947)3.57974967
35Sex reversal (HP:0012245)3.53578707
36Abnormal sex determination (HP:0012244)3.53578707
37Atrophic scars (HP:0001075)3.47684032
38Abnormality of oral frenula (HP:0000190)3.46835983
39Abnormality of glycine metabolism (HP:0010895)3.41989511
40Abnormality of serine family amino acid metabolism (HP:0010894)3.41989511
41Protrusio acetabuli (HP:0003179)3.40600325
42Conjugated hyperbilirubinemia (HP:0002908)3.37621140
43Abnormality of nucleobase metabolism (HP:0010932)3.36596308
44Vascular tortuosity (HP:0004948)3.33209025
45Unilateral renal agenesis (HP:0000122)3.32895771
46Delayed epiphyseal ossification (HP:0002663)3.30364387
47Ankyloglossia (HP:0010296)3.28168484
48Hyperacusis (HP:0010780)3.27759398
49Hyperphosphaturia (HP:0003109)3.27353105
50Milia (HP:0001056)3.18207587
51Vertebral arch anomaly (HP:0008438)3.16279251
52Abnormal urine phosphate concentration (HP:0012599)3.16247568
53Abnormality of proline metabolism (HP:0010907)3.14339736
54Hydroxyprolinuria (HP:0003080)3.14339736
55Ketoacidosis (HP:0001993)3.13678489
56Missing ribs (HP:0000921)3.13651490
57Focal segmental glomerulosclerosis (HP:0000097)3.12423654
58Abnormality of the nasal septum (HP:0000419)3.10992659
59Osteolytic defects of the phalanges of the hand (HP:0009771)3.05007000
60Osteolytic defects of the hand bones (HP:0009699)3.05007000
61Fragile skin (HP:0001030)3.04759808
62Abnormality of potassium homeostasis (HP:0011042)3.04521747
6311 pairs of ribs (HP:0000878)3.04503722
64Glossoptosis (HP:0000162)2.97095507
65Vascular calcification (HP:0004934)2.89523548
66Broad metatarsal (HP:0001783)2.86196514
67Shallow orbits (HP:0000586)2.84038906
68Hypophosphatemia (HP:0002148)2.78952599
69Ketosis (HP:0001946)2.74008701
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72418429
71Neurofibrillary tangles (HP:0002185)2.70883514
72Cardiovascular calcification (HP:0011915)2.68982330
73* Nephrolithiasis (HP:0000787)2.68855481
74Turricephaly (HP:0000262)2.67738947
75Rickets (HP:0002748)2.66818260
76* Nephrocalcinosis (HP:0000121)2.65150433
77Abnormality of the gastric mucosa (HP:0004295)2.64938482
78Flat acetabular roof (HP:0003180)2.64770295
79Aplasia/Hypoplasia of the scapulae (HP:0006713)2.64339761
80Hypoplastic scapulae (HP:0000882)2.64339761
81Metaphyseal cupping (HP:0003021)2.60797344
82Cone-rod dystrophy (HP:0000548)2.56996243
83Insomnia (HP:0100785)2.55602992
84Ankle contracture (HP:0006466)2.54348786
85Nail dystrophy (HP:0008404)2.49860829
86Wormian bones (HP:0002645)2.47348935
87Hyperglycinemia (HP:0002154)2.47271213
88Thin bony cortex (HP:0002753)2.45971059
89* Dehydration (HP:0001944)2.45343571
90Hyperammonemia (HP:0001987)2.45062980
91Ulnar bowing (HP:0003031)2.43615315
92Confusion (HP:0001289)2.42896211
93Deviation of the thumb (HP:0009603)2.41309640
94Tibial bowing (HP:0002982)2.40255337
95Abnormal ossification of hand bones (HP:0005921)2.38875052
96Lymphangioma (HP:0100764)2.35286513
97Abnormality of fatty-acid metabolism (HP:0004359)2.34661003
98Malnutrition (HP:0004395)2.33745107
99Delayed CNS myelination (HP:0002188)2.33251826
100Cerebral inclusion bodies (HP:0100314)2.30143777
101Abnormal number of incisors (HP:0011064)2.29504896
102Small epiphyses (HP:0010585)2.29365470
103Vacuolated lymphocytes (HP:0001922)2.28322589
104Tubular atrophy (HP:0000092)2.26869463
105Abnormal enzyme/coenzyme activity (HP:0012379)2.25645270
106Widely patent fontanelles and sutures (HP:0004492)2.24809104
107Abnormality of the distal phalanx of the thumb (HP:0009617)2.24608784
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24379820
109Abnormality of sodium homeostasis (HP:0010931)2.22950457
110Glucose intolerance (HP:0000833)2.22778470
111Dicarboxylic aciduria (HP:0003215)2.21224459
112Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21224459
113Ureteral stenosis (HP:0000071)2.20336378
114Renal tubular dysfunction (HP:0000124)2.19952211
115Abnormality of renal resorption (HP:0011038)2.19058125
116Abnormality of alkaline phosphatase activity (HP:0004379)2.18624086
117Hyponatremia (HP:0002902)2.14301345
118Squamous cell carcinoma (HP:0002860)2.13113081
119Enlarged kidneys (HP:0000105)2.11972330
120Rhizomelia (HP:0008905)2.11886078
121Wide nose (HP:0000445)2.11591522
122Hypoplasia of the uterus (HP:0000013)2.11551029
123Pterygium (HP:0001059)2.10782567
124Short nail (HP:0001799)2.10417690
125Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09982030
126Subacute progressive viral hepatitis (HP:0006572)2.09700992
127Adrenal overactivity (HP:0002717)2.09554713
128Coronal craniosynostosis (HP:0004440)2.09420440
129Fibular hypoplasia (HP:0003038)2.09390824
130Potter facies (HP:0002009)2.08647116
131Facial shape deformation (HP:0011334)2.08647116
132Aplasia/Hypoplasia of the fibula (HP:0006492)2.08412853
133Tubulointerstitial fibrosis (HP:0005576)2.06597370
134Poikiloderma (HP:0001029)2.06588068
135Bilateral sensorineural hearing impairment (HP:0008619)2.06409867
136Ureteral obstruction (HP:0006000)2.05746306
137Plantar hyperkeratosis (HP:0007556)2.05484130
138Short humerus (HP:0005792)2.05180956
139Prolonged neonatal jaundice (HP:0006579)2.04569852
140Broad palm (HP:0001169)2.04397344
141Corneal erosion (HP:0200020)2.02179985
142Abnormal pancreas size (HP:0012094)2.01573319
143Vertebral compression fractures (HP:0002953)2.01421333
144* Vomiting (HP:0002013)2.01412036
145Abnormal tarsal ossification (HP:0008369)2.00199689
146Alopecia of scalp (HP:0002293)2.00094069
147Enlarged penis (HP:0000040)1.99877685
148Onycholysis (HP:0001806)1.98385906
149Proximal placement of thumb (HP:0009623)1.98186562
150Trismus (HP:0000211)1.97855919
151Premature rupture of membranes (HP:0001788)1.97684548
152Trigonocephaly (HP:0000243)1.96986207
153Right ventricular cardiomyopathy (HP:0011663)1.96599508
154Abnormality of carpal bone ossification (HP:0006257)1.96542036
155Metabolic acidosis (HP:0001942)1.96413087
156Methylmalonic aciduria (HP:0012120)1.95432203
157Fibular aplasia (HP:0002990)1.94329901
158Ridged nail (HP:0001807)1.93737981
159Orthostatic hypotension (HP:0001278)1.93651532
160Chondrocalcinosis (HP:0000934)1.92469738
161Hypoplasia of dental enamel (HP:0006297)1.91642522
162Chorioretinal atrophy (HP:0000533)1.91433304
163Decreased circulating renin level (HP:0003351)1.91095255
164Hypercholesterolemia (HP:0003124)1.88709401
165Humeroradial synostosis (HP:0003041)1.87976634
166Synostosis involving the elbow (HP:0003938)1.87976634
167Hypophosphatemic rickets (HP:0004912)1.87392697
168Bicornuate uterus (HP:0000813)1.86919091
169Abnormality of sulfur amino acid metabolism (HP:0004339)1.86778981
170Midface retrusion (HP:0011800)1.86522994
171Thick nail (HP:0001805)1.85819435
172Multiple enchondromatosis (HP:0005701)1.85558121
173Cervical subluxation (HP:0003308)1.85513026
174Glomerulosclerosis (HP:0000096)1.83903877
175Abnormality of the acetabulum (HP:0003170)1.83283233
176Arnold-Chiari malformation (HP:0002308)1.82210299
177Abnormality of Sharpey fibers (HP:0100685)1.82066825
178Micronodular cirrhosis (HP:0001413)1.81783436
179* Elfin facies (HP:0004428)1.81324245
180Bowed forearm bones (HP:0003956)1.81147626
181Bowing of the arm (HP:0006488)1.81147626
182Limited elbow extension (HP:0001377)1.79818581
183Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.79260821
184Vertebral hypoplasia (HP:0008417)1.79260821
185Sensorimotor neuropathy (HP:0007141)1.78895043
186Axonal loss (HP:0003447)1.77975940
187Abnormality of the costochondral junction (HP:0000919)1.77936617
188Elevated alkaline phosphatase (HP:0003155)1.77473456
189Blepharitis (HP:0000498)1.76969253
190Aplasia/hypoplasia of the humerus (HP:0006507)1.76852525
191* Lethargy (HP:0001254)1.76370189
192Nausea (HP:0002018)1.73375693
193Metaphyseal irregularity (HP:0003025)1.72981096
194Enlarged epiphyses (HP:0010580)1.70592989
195Metaphyseal dysplasia (HP:0100255)1.68639292
196Abnormality of serum amino acid levels (HP:0003112)1.64813598
197Persistence of primary teeth (HP:0006335)1.63819020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.95342108
2OXSR17.05417812
3WNK36.26883159
4STK394.99368805
5TTN3.17172422
6MST42.73407915
7STK38L2.70467580
8CDK122.35740460
9BCKDK2.07141503
10PBK1.94286680
11LMTK21.90630364
12PIK3CG1.89348569
13PDK31.88640218
14PDK41.88640218
15EIF2AK11.84688215
16FRK1.80352012
17WNK11.77113080
18SGK2231.60303540
19SGK4941.60303540
20CDK81.56827848
21STK381.56324027
22NEK11.54458718
23RIPK11.47331067
24MST1R1.45680023
25MAP3K91.31697119
26TRPM71.25860037
27FLT31.24113115
28TAOK31.20604959
29PDK21.19824018
30MAP3K71.13232243
31RPS6KB21.02832486
32TESK11.01289697
33EPHB10.99729393
34GSK3A0.92269766
35MELK0.92201512
36LIMK10.88431875
37LRRK20.88346098
38ERBB30.88325142
39SGK30.84965327
40FER0.83505872
41BRSK10.82600535
42LATS10.81802201
43FGFR40.80270455
44BRSK20.79000091
45PTK60.74117578
46MAP3K30.73365782
47PTK20.73153423
48EPHA30.71386477
49ERBB40.68656063
50EEF2K0.67266917
51JAK30.66831511
52MAP3K20.66264378
53TSSK60.66081988
54FGR0.65040094
55PAK30.63895866
56CDK90.63556516
57ABL20.63037853
58GRK60.62424021
59NTRK10.61917934
60SGK10.61502117
61AURKB0.59821780
62TGFBR20.59401179
63DYRK1B0.57829974
64SGK20.56996373
65EIF2AK30.55295921
66PIK3CA0.53563553
67CAMK2B0.53208456
68ICK0.52883255
69PIM20.52258185
70TTK0.50734296
71JAK10.50536244
72ALK0.49831254
73EIF2AK20.49071233
74ERN10.48862768
75STK110.46103289
76MET0.45474689
77CAMK2G0.45436355
78CSF1R0.44616466
79PRPF4B0.43497921
80EPHA20.42625819
81SCYL20.42329830
82STK100.42159223
83PAK40.42088171
84PRKCE0.41996754
85EPHB20.40591292
86ARAF0.39599645
87BCR0.38488110
88PRKAA10.38485299
89MAPK110.37784418
90NEK20.37539896
91NEK60.37452232
92CDK40.36396876
93PRKD30.36371942
94DDR20.36007252
95IRAK10.35949540
96PRKG20.35603745
97SIK10.35487054
98AURKA0.35211142
99IRAK30.34856924
100BRD40.34526041
101CHUK0.33671599
102BUB10.32964115
103CDK70.32462170
104NEK90.31355987
105IGF1R0.29724951
106PRKAA20.29579201
107CAMK2D0.29317210
108PLK10.28364164
109PDPK10.28008479
110INSRR0.27419474
111FGFR30.26564506
112PRKCZ0.26385554
113STK40.26263459
114KSR10.26251617
115PDGFRA0.25746397
116MAP3K140.25649846
117AKT20.25370661
118SMG10.25205000
119IRAK20.24346593
120PRKCI0.23254869
121MAPKAPK30.23209032
122FGFR20.22909619
123PINK10.22123550
124PAK20.22043716
125BMPR20.21800918
126TIE10.20448297
127ROCK10.19299880
128PRKD20.19260880
129STK30.19248569
130BMX0.19071398
131LATS20.18239776
132MAP3K80.14778713
133PDK10.14651148
134PRKCA0.13597371
135TRIB30.13485919
136PRKACG0.11783880
137ABL10.10687026
138CSNK1E0.10505404
139INSR0.10192400
140MYLK0.10063019
141SRC0.09341220
142PRKCD0.09205079
143PRKACA0.08926176
144PTK2B0.06722827
145NME20.06396402
146PRKCQ0.05690002
147CDK60.05417054
148ZAK0.04994150
149ERBB20.04483431
150PDGFRB0.04116793
151CAMK1G0.04077264
152FGFR10.03934144
153MTOR0.03862628
154CAMK40.03404644
155EGFR0.03237915

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.94730862
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.51394672
3Propanoate metabolism_Homo sapiens_hsa006403.23023242
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.12650561
5Butanoate metabolism_Homo sapiens_hsa006503.09937873
6Adherens junction_Homo sapiens_hsa045203.05002587
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.93818116
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.92337180
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90804328
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.78827274
11Vitamin B6 metabolism_Homo sapiens_hsa007502.65942802
12Nitrogen metabolism_Homo sapiens_hsa009102.51059600
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49612971
14Small cell lung cancer_Homo sapiens_hsa052222.47915227
15Pyruvate metabolism_Homo sapiens_hsa006202.46091972
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37896669
17Fatty acid degradation_Homo sapiens_hsa000712.26355436
18Collecting duct acid secretion_Homo sapiens_hsa049662.25808556
19Central carbon metabolism in cancer_Homo sapiens_hsa052302.23981861
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.22009022
21Vitamin digestion and absorption_Homo sapiens_hsa049772.18658773
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16714245
23Peroxisome_Homo sapiens_hsa041462.10285199
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01868818
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99478295
26Proteoglycans in cancer_Homo sapiens_hsa052051.96220334
27Tryptophan metabolism_Homo sapiens_hsa003801.94711720
28beta-Alanine metabolism_Homo sapiens_hsa004101.86075752
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83368127
30Bile secretion_Homo sapiens_hsa049761.83352707
31Glutathione metabolism_Homo sapiens_hsa004801.83166719
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79471349
33Mineral absorption_Homo sapiens_hsa049781.74517064
34Carbon metabolism_Homo sapiens_hsa012001.69639145
35Hippo signaling pathway_Homo sapiens_hsa043901.65487416
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65294245
37Sulfur metabolism_Homo sapiens_hsa009201.62293254
38Fatty acid metabolism_Homo sapiens_hsa012121.57700358
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57461276
40Arginine and proline metabolism_Homo sapiens_hsa003301.46883187
41Protein digestion and absorption_Homo sapiens_hsa049741.44401723
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44067827
43Arginine biosynthesis_Homo sapiens_hsa002201.42554984
44Pancreatic cancer_Homo sapiens_hsa052121.42107211
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38282057
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31891080
47Non-homologous end-joining_Homo sapiens_hsa034501.29576117
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28670563
49* MicroRNAs in cancer_Homo sapiens_hsa052061.28375209
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27712574
51Chronic myeloid leukemia_Homo sapiens_hsa052201.27046194
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26018472
53Starch and sucrose metabolism_Homo sapiens_hsa005001.23867430
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23317499
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22863893
56Other glycan degradation_Homo sapiens_hsa005111.21102799
57Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21020535
58p53 signaling pathway_Homo sapiens_hsa041151.13997319
59PPAR signaling pathway_Homo sapiens_hsa033201.13065615
60Folate biosynthesis_Homo sapiens_hsa007901.12438841
61Lysine degradation_Homo sapiens_hsa003101.12159466
62Cell cycle_Homo sapiens_hsa041101.12136739
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10918927
64ErbB signaling pathway_Homo sapiens_hsa040121.09627950
65Histidine metabolism_Homo sapiens_hsa003401.07370996
66DNA replication_Homo sapiens_hsa030301.06195728
67Phenylalanine metabolism_Homo sapiens_hsa003601.05244543
68Shigellosis_Homo sapiens_hsa051311.02596168
69Dilated cardiomyopathy_Homo sapiens_hsa054141.01531516
70Pyrimidine metabolism_Homo sapiens_hsa002401.00295329
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98192352
72Pathways in cancer_Homo sapiens_hsa052000.95717499
73TGF-beta signaling pathway_Homo sapiens_hsa043500.95304792
74Renal cell carcinoma_Homo sapiens_hsa052110.94357507
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91533640
76Fatty acid biosynthesis_Homo sapiens_hsa000610.91045554
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89672937
78Gastric acid secretion_Homo sapiens_hsa049710.86787735
79Biosynthesis of amino acids_Homo sapiens_hsa012300.86122769
80Amoebiasis_Homo sapiens_hsa051460.85463948
81Selenocompound metabolism_Homo sapiens_hsa004500.85294796
82Nucleotide excision repair_Homo sapiens_hsa034200.83689807
83N-Glycan biosynthesis_Homo sapiens_hsa005100.82855036
84Renin-angiotensin system_Homo sapiens_hsa046140.82113054
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81325231
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.79604544
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79080628
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79063429
89Glycerolipid metabolism_Homo sapiens_hsa005610.78435336
90RNA transport_Homo sapiens_hsa030130.77775900
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.75733248
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74852543
93Melanoma_Homo sapiens_hsa052180.74461894
94Fructose and mannose metabolism_Homo sapiens_hsa000510.74437032
95Notch signaling pathway_Homo sapiens_hsa043300.71912823
96Chemical carcinogenesis_Homo sapiens_hsa052040.70081915
97mTOR signaling pathway_Homo sapiens_hsa041500.66557021
98Pentose phosphate pathway_Homo sapiens_hsa000300.66530915
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66365777
100Mismatch repair_Homo sapiens_hsa034300.66224602
101Thyroid hormone synthesis_Homo sapiens_hsa049180.66074657
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.65431219
103Insulin signaling pathway_Homo sapiens_hsa049100.64894915
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64074698
105Endocytosis_Homo sapiens_hsa041440.63468132
106Hepatitis C_Homo sapiens_hsa051600.62256378
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.61751833
108Apoptosis_Homo sapiens_hsa042100.61662285
109Fatty acid elongation_Homo sapiens_hsa000620.59199950
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.58917067
111Basal cell carcinoma_Homo sapiens_hsa052170.57903835
112Axon guidance_Homo sapiens_hsa043600.57582709
113Oxidative phosphorylation_Homo sapiens_hsa001900.57444344
114African trypanosomiasis_Homo sapiens_hsa051430.56844713
115Glioma_Homo sapiens_hsa052140.54603108
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54463853
117Retinol metabolism_Homo sapiens_hsa008300.53529516
118Base excision repair_Homo sapiens_hsa034100.53251752
119Vibrio cholerae infection_Homo sapiens_hsa051100.52686372
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51218291
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50521683
122Viral carcinogenesis_Homo sapiens_hsa052030.47929391
123One carbon pool by folate_Homo sapiens_hsa006700.46664987
124Lysosome_Homo sapiens_hsa041420.46367432
125TNF signaling pathway_Homo sapiens_hsa046680.45988831
126Thyroid cancer_Homo sapiens_hsa052160.45516548
127ABC transporters_Homo sapiens_hsa020100.43962403
128* Metabolic pathways_Homo sapiens_hsa011000.43741722
129Rap1 signaling pathway_Homo sapiens_hsa040150.43483535
130Prostate cancer_Homo sapiens_hsa052150.43202324
131Wnt signaling pathway_Homo sapiens_hsa043100.43143445
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42990186
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41723597
134Spliceosome_Homo sapiens_hsa030400.40657210
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.32442188
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29940145
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29611784
138ECM-receptor interaction_Homo sapiens_hsa045120.28378393
139Synaptic vesicle cycle_Homo sapiens_hsa047210.23513866
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23038225
141Hedgehog signaling pathway_Homo sapiens_hsa043400.22169966
142Arachidonic acid metabolism_Homo sapiens_hsa005900.21762055
143Tight junction_Homo sapiens_hsa045300.20319647
144Sphingolipid metabolism_Homo sapiens_hsa006000.19901732
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.19894038
146Tyrosine metabolism_Homo sapiens_hsa003500.17989822
147Parkinsons disease_Homo sapiens_hsa050120.17748427
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.16211202
149Inositol phosphate metabolism_Homo sapiens_hsa005620.15957423
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15853988
151Insulin resistance_Homo sapiens_hsa049310.13433171
152AMPK signaling pathway_Homo sapiens_hsa041520.13037242
153Pancreatic secretion_Homo sapiens_hsa049720.11324548
154Bladder cancer_Homo sapiens_hsa052190.10708874
155Galactose metabolism_Homo sapiens_hsa000520.10671184
156Choline metabolism in cancer_Homo sapiens_hsa052310.10596109
157Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09509281
158Cardiac muscle contraction_Homo sapiens_hsa042600.07902965
159Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07759944
160Glucagon signaling pathway_Homo sapiens_hsa049220.07378968
161Salivary secretion_Homo sapiens_hsa049700.05544926
162Alzheimers disease_Homo sapiens_hsa050100.02266680
163Rheumatoid arthritis_Homo sapiens_hsa053230.00341196
164Focal adhesion_Homo sapiens_hsa04510-0.0037767

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