CYP1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alkaloid metabolic process (GO:0009820)7.35787310
2hormone catabolic process (GO:0042447)7.02108222
3* drug metabolic process (GO:0017144)6.96776689
4* toxin metabolic process (GO:0009404)5.67218052
5daunorubicin metabolic process (GO:0044597)5.36065887
6polyketide metabolic process (GO:0030638)5.36065887
7doxorubicin metabolic process (GO:0044598)5.36065887
8ethanol metabolic process (GO:0006067)5.16936029
9cellular response to cadmium ion (GO:0071276)5.10592793
10oxidative demethylation (GO:0070989)5.07067104
11ethanol oxidation (GO:0006069)5.00752133
12Golgi transport vesicle coating (GO:0048200)4.97462251
13COPI coating of Golgi vesicle (GO:0048205)4.97462251
14positive regulation of extracellular matrix organization (GO:1903055)4.90784866
15epithelial cell-cell adhesion (GO:0090136)4.88204582
16desmosome organization (GO:0002934)4.87221089
17coenzyme catabolic process (GO:0009109)4.80879439
18intestinal cholesterol absorption (GO:0030299)4.53735477
19* flavonoid metabolic process (GO:0009812)4.51936589
20positive regulation of keratinocyte differentiation (GO:0045618)4.51837416
21nitric oxide biosynthetic process (GO:0006809)4.49244600
22cellular modified amino acid catabolic process (GO:0042219)4.43907166
23vitamin A metabolic process (GO:0006776)4.29097854
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.22424672
25retinal metabolic process (GO:0042574)4.16449693
26sulfur amino acid catabolic process (GO:0000098)4.14455107
27* hydrogen peroxide biosynthetic process (GO:0050665)4.11216618
28L-phenylalanine catabolic process (GO:0006559)4.06143513
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.06143513
30intestinal absorption (GO:0050892)4.02211956
31steroid catabolic process (GO:0006706)4.01488945
32vitamin transmembrane transport (GO:0035461)4.01352830
33L-phenylalanine metabolic process (GO:0006558)3.97054287
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.97054287
35negative regulation of fibrinolysis (GO:0051918)3.96167687
36cellular glucuronidation (GO:0052695)3.91871283
37interferon-gamma secretion (GO:0072643)3.91817221
38pentose-phosphate shunt (GO:0006098)3.89922280
39ear development (GO:0043583)3.89717952
40glucose 6-phosphate metabolic process (GO:0051156)3.85297963
41positive regulation of Cdc42 GTPase activity (GO:0043089)3.83479071
42intestinal epithelial cell development (GO:0060576)3.72173693
43heme transport (GO:0015886)3.67817186
44hepatocyte apoptotic process (GO:0097284)3.62481558
45NADPH regeneration (GO:0006740)3.61153633
46regulation of water loss via skin (GO:0033561)3.55252670
47retina vasculature morphogenesis in camera-type eye (GO:0061299)3.55053319
48aromatic amino acid family catabolic process (GO:0009074)3.54511319
49angiotensin maturation (GO:0002003)3.54376328
50* reactive oxygen species biosynthetic process (GO:1903409)3.53705565
51positive regulation of epidermal cell differentiation (GO:0045606)3.52565913
52norepinephrine metabolic process (GO:0042415)3.49632930
53glucose catabolic process (GO:0006007)3.48424797
54high-density lipoprotein particle remodeling (GO:0034375)3.48071797
55positive regulation of cellular amine metabolic process (GO:0033240)3.46369023
56calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.44066971
57regulation of fibrinolysis (GO:0051917)3.43844448
58cofactor catabolic process (GO:0051187)3.42184734
59uronic acid metabolic process (GO:0006063)3.39631396
60glucuronate metabolic process (GO:0019585)3.39631396
61primary alcohol metabolic process (GO:0034308)3.39214163
62regulation of extracellular matrix organization (GO:1903053)3.37806857
63surfactant homeostasis (GO:0043129)3.37258847
64aminoglycoside antibiotic metabolic process (GO:0030647)3.31085821
65regulation of triglyceride catabolic process (GO:0010896)3.30235937
66somite rostral/caudal axis specification (GO:0032525)3.29824543
67multicellular organismal water homeostasis (GO:0050891)3.28153257
68retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.26348245
69primary alcohol catabolic process (GO:0034310)3.25579622
70urea cycle (GO:0000050)3.24485231
71urea metabolic process (GO:0019627)3.24485231
72artery smooth muscle contraction (GO:0014824)3.22867279
73transepithelial transport (GO:0070633)3.20152559
74homocysteine metabolic process (GO:0050667)3.18489301
75regulation of bile acid biosynthetic process (GO:0070857)3.17512158
76regulation of cell proliferation involved in kidney development (GO:1901722)3.16717826
77kynurenine metabolic process (GO:0070189)3.16703965
78maintenance of protein location in nucleus (GO:0051457)3.15773370
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.14883963
80L-ascorbic acid metabolic process (GO:0019852)3.13483612
81negative regulation of cholesterol transport (GO:0032375)3.12602774
82negative regulation of sterol transport (GO:0032372)3.12602774
83lysine metabolic process (GO:0006553)3.12572991
84lysine catabolic process (GO:0006554)3.12572991
85regulation of cholesterol biosynthetic process (GO:0045540)3.12268718
86positive regulation of hormone metabolic process (GO:0032352)3.08983549
87negative regulation of epidermis development (GO:0045683)3.08093742
88bile acid biosynthetic process (GO:0006699)3.07785619
89cysteine metabolic process (GO:0006534)3.06648537
90biotin metabolic process (GO:0006768)3.06235402
91negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.05653737
92reverse cholesterol transport (GO:0043691)3.04963838
93regulation of keratinocyte differentiation (GO:0045616)3.04898615
94fatty acid derivative transport (GO:1901571)3.04594286
95icosanoid transport (GO:0071715)3.04594286
96branching involved in mammary gland duct morphogenesis (GO:0060444)3.03268254
97alpha-linolenic acid metabolic process (GO:0036109)3.03002835
98regulation of response to osmotic stress (GO:0047484)3.02673827
99striated muscle atrophy (GO:0014891)3.02182495
100cellular aldehyde metabolic process (GO:0006081)3.01134352
101positive regulation of lipoprotein lipase activity (GO:0051006)3.00933246
102positive regulation of triglyceride lipase activity (GO:0061365)3.00933246
103regulation of cholesterol homeostasis (GO:2000188)2.97723459
104cholesterol homeostasis (GO:0042632)2.97262319
105indole-containing compound catabolic process (GO:0042436)2.96963532
106indolalkylamine catabolic process (GO:0046218)2.96963532
107tryptophan catabolic process (GO:0006569)2.96963532
108proline biosynthetic process (GO:0006561)2.96765977
109retinol metabolic process (GO:0042572)2.96598279
110muscle organ morphogenesis (GO:0048644)2.96228996
111negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.95491564
112regulation of mammary gland epithelial cell proliferation (GO:0033599)2.95254675
113protein carboxylation (GO:0018214)2.95202643
114peptidyl-glutamic acid carboxylation (GO:0017187)2.95202643
115triglyceride homeostasis (GO:0070328)2.93268289
116acylglycerol homeostasis (GO:0055090)2.93268289
117sterol homeostasis (GO:0055092)2.92778989
118dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.92617829
119glutamate metabolic process (GO:0006536)2.91382251
120phospholipid efflux (GO:0033700)2.91325956
121proline metabolic process (GO:0006560)2.90942671
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90855046
123cytidine catabolic process (GO:0006216)2.90324416
124cytidine deamination (GO:0009972)2.90324416
125cytidine metabolic process (GO:0046087)2.90324416
126axonemal dynein complex assembly (GO:0070286)2.89141261
127pentose metabolic process (GO:0019321)2.89038927
128NADH metabolic process (GO:0006734)2.88769955
129regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.88233562
130regulation of endothelial cell differentiation (GO:0045601)2.88217753
131cholesterol efflux (GO:0033344)2.87638696
132tryptophan metabolic process (GO:0006568)2.87542637
133gap junction assembly (GO:0016264)2.87116020
134plasma lipoprotein particle remodeling (GO:0034369)2.87036324
135protein-lipid complex remodeling (GO:0034368)2.87036324
136macromolecular complex remodeling (GO:0034367)2.87036324
137nucleoside transmembrane transport (GO:1901642)2.85643991
138pyrimidine nucleoside catabolic process (GO:0046135)2.85491614
139nitrogen cycle metabolic process (GO:0071941)2.85413897
140bile acid metabolic process (GO:0008206)2.80804634
141protein retention in ER lumen (GO:0006621)2.80052091
142lipoprotein metabolic process (GO:0042157)2.78909123
143regulation of cholesterol esterification (GO:0010872)2.76950049
144amino-acid betaine metabolic process (GO:0006577)2.74240390
145water homeostasis (GO:0030104)2.73795414
146phenol-containing compound catabolic process (GO:0019336)2.73444154
147plasma lipoprotein particle clearance (GO:0034381)2.72735777
148cell differentiation involved in embryonic placenta development (GO:0060706)2.72363865
149nucleobase catabolic process (GO:0046113)2.72100036
150epithelial cell differentiation involved in prostate gland development (GO:0060742)2.70729280
151glyoxylate metabolic process (GO:0046487)2.65863779
152muscle atrophy (GO:0014889)2.64977193
153glutamine family amino acid biosynthetic process (GO:0009084)2.64246661
154skeletal muscle adaptation (GO:0043501)2.63408058
155tonic smooth muscle contraction (GO:0014820)2.61683923
156membrane lipid catabolic process (GO:0046466)2.60411171
157maternal placenta development (GO:0001893)2.59019941
158* diterpenoid biosynthetic process (GO:0016102)2.58274120
159ER overload response (GO:0006983)2.56820394
160NADP metabolic process (GO:0006739)2.53554782
161bundle of His cell to Purkinje myocyte communication (GO:0086069)2.48394623
162glutathione derivative metabolic process (GO:1901685)2.47838978
163glutathione derivative biosynthetic process (GO:1901687)2.47838978
164COPII vesicle coating (GO:0048208)2.46895756
165carnitine metabolic process (GO:0009437)2.46787183
166regulation of cholesterol metabolic process (GO:0090181)2.46696128
167pyrimidine-containing compound transmembrane transport (GO:0072531)2.46068657
168regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.45415435
169vagina development (GO:0060068)2.44659587
170establishment of skin barrier (GO:0061436)2.44557412
171* epoxygenase P450 pathway (GO:0019373)17.4293157
172* omega-hydroxylase P450 pathway (GO:0097267)14.7379256
173exogenous drug catabolic process (GO:0042738)11.6369138
174drug catabolic process (GO:0042737)10.5792316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.84538397
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.49276459
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.62402217
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.62402217
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.62402217
6RXR_22158963_ChIP-Seq_LIVER_Mouse4.32778890
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.88733528
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.69765851
9ZNF263_19887448_ChIP-Seq_K562_Human3.57701596
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.57226733
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.15098122
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.97317585
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.87171226
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.68573396
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.65274007
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.59792678
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.56264950
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.50725072
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.38458972
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.37478065
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.26748074
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.22006902
23NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.13247017
24TCF3_18692474_ChIP-Seq_MESCs_Mouse2.03714789
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03126691
26* AHR_22903824_ChIP-Seq_MCF-7_Human2.02708586
27GATA1_22025678_ChIP-Seq_K562_Human2.02558984
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91155858
29CLOCK_20551151_ChIP-Seq_293T_Human1.87706974
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.87252712
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86262232
32* GATA3_24758297_ChIP-Seq_MCF-7_Human1.79979507
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.79280116
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68212483
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65853937
36* ESR2_21235772_ChIP-Seq_MCF-7_Human1.64435680
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61248430
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56687643
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55037284
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.46737921
41TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44794584
42NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.44503964
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44488673
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44073318
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43625398
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42126852
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41465179
48NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.41289833
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38524080
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36760084
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36254817
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34378870
53RACK7_27058665_Chip-Seq_MCF-7_Human1.34104623
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33985888
55LXR_22292898_ChIP-Seq_THP-1_Human1.33408089
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32953503
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31912062
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.28862383
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.28389992
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.27518854
61OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26685176
62NANOG_18692474_ChIP-Seq_MEFs_Mouse1.25514072
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22879121
64SOX2_20726797_ChIP-Seq_SW620_Human1.18535967
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18484367
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18484367
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17440393
68POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17330332
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16594536
70GATA4_25053715_ChIP-Seq_YYC3_Human1.16082326
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15159838
72TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14785120
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14664900
74GATA6_25053715_ChIP-Seq_YYC3_Human1.14504368
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.14148696
76NANOG_18692474_ChIP-Seq_MESCs_Mouse1.14054565
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12827395
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.12521296
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.11265571
80CREB1_26743006_Chip-Seq_LNCaP_Human1.11033238
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10690648
82EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08941477
83ELF5_23300383_ChIP-Seq_T47D_Human1.08271047
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07655338
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06583740
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05608105
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05286783
88SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04825139
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04136589
90PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04052829
91* AR_21909140_ChIP-Seq_LNCAP_Human1.03735126
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02964069
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02568656
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01713939
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.01088636
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00185960
97NCOR1_26117541_ChIP-Seq_K562_Human0.99677441
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98310188
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97717371
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97056234
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96434511
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96411706
103NANOG_16518401_ChIP-PET_MESCs_Mouse0.96037025
104* ESR1_21235772_ChIP-Seq_MCF-7_Human0.95728128
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93977929
106POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93797944
107PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93721106
108TP53_22127205_ChIP-Seq_IMR90_Human0.93239002
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93101141
110MYC_18555785_ChIP-Seq_MESCs_Mouse0.93036841
111CHD1_26751641_Chip-Seq_LNCaP_Human0.92542707
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91989201
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91954325
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90991330
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90846303
116KDM2B_26808549_Chip-Seq_K562_Human0.89669424
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89255393
118SMC4_20622854_ChIP-Seq_HELA_Human0.88640070
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88451204
120SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88054342
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87728648
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87508919
123* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87355385
124FOXA2_19822575_ChIP-Seq_HepG2_Human0.86572276
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86097923
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85969390
127RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85646290
128* HNF4A_19822575_ChIP-Seq_HepG2_Human0.85160959
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85129317
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84305978
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.83810216
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83374699
133TCF7_22412390_ChIP-Seq_EML_Mouse0.82435491
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79221287
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77444365
136* BCOR_27268052_Chip-Seq_Bcells_Human0.77160907
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76759067
138ATF3_27146783_Chip-Seq_COLON_Human0.76409301
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76222801
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75729447
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74705208
142* P68_20966046_ChIP-Seq_HELA_Human0.72651935
143* IRF1_19129219_ChIP-ChIP_H3396_Human0.72612166
144KLF5_25053715_ChIP-Seq_YYC3_Human0.72411056
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71850634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008875_abnormal_xenobiotic_pharmacok6.99381627
2MP0005360_urolithiasis6.18727234
3MP0002139_abnormal_hepatobiliary_system5.44484966
4MP0005085_abnormal_gallbladder_physiolo4.04723266
5MP0005365_abnormal_bile_salt3.51012594
6MP0004782_abnormal_surfactant_physiolog3.34311144
7MP0003705_abnormal_hypodermis_morpholog2.99733561
8MP0002254_reproductive_system_inflammat2.96360165
9MP0010368_abnormal_lymphatic_system2.91249605
10MP0003011_delayed_dark_adaptation2.89009924
11MP0004264_abnormal_extraembryonic_tissu2.87578200
12MP0003252_abnormal_bile_duct2.76488816
13MP0010329_abnormal_lipoprotein_level2.66339231
14MP0002138_abnormal_hepatobiliary_system2.54241258
15MP0000566_synostosis2.47481311
16MP0001666_abnormal_nutrient_absorption2.45634669
17MP0005501_abnormal_skin_physiology2.31807422
18MP0003806_abnormal_nucleotide_metabolis2.30662799
19MP0000383_abnormal_hair_follicle2.20377438
20MP0005076_abnormal_cell_differentiation2.18076054
21MP0005451_abnormal_body_composition2.17525469
22MP0009780_abnormal_chondrocyte_physiolo2.16700886
23MP0010678_abnormal_skin_adnexa2.15155580
24MP0004233_abnormal_muscle_weight2.07767028
25MP0009840_abnormal_foam_cell2.07562132
26MP0005058_abnormal_lysosome_morphology1.90547459
27MP0005167_abnormal_blood-brain_barrier1.89661434
28MP0004858_abnormal_nervous_system1.89414077
29MP0003941_abnormal_skin_development1.83928612
30MP0002332_abnormal_exercise_endurance1.80627998
31MP0004019_abnormal_vitamin_homeostasis1.79140959
32MP0010352_gastrointestinal_tract_polyps1.72561746
33* MP0005319_abnormal_enzyme/_coenzyme1.72224110
34MP0005332_abnormal_amino_acid1.63900985
35* MP0000609_abnormal_liver_physiology1.62279828
36MP0003453_abnormal_keratinocyte_physiol1.61030453
37MP0003890_abnormal_embryonic-extraembry1.60255265
38MP0000627_abnormal_mammary_gland1.52383723
39MP0008961_abnormal_basal_metabolism1.49771220
40MP0005409_darkened_coat_color1.47103665
41MP0000377_abnormal_hair_follicle1.45966393
42MP0005408_hypopigmentation1.45846669
43MP0003183_abnormal_peptide_metabolism1.44551209
44MP0002132_abnormal_respiratory_system1.42319789
45MP0003191_abnormal_cellular_cholesterol1.41712667
46MP0002277_abnormal_respiratory_mucosa1.41464791
47MP0000467_abnormal_esophagus_morphology1.37956482
48MP0002909_abnormal_adrenal_gland1.35965606
49MP0005499_abnormal_olfactory_system1.33533225
50MP0005394_taste/olfaction_phenotype1.33533225
51MP0001727_abnormal_embryo_implantation1.28118273
52MP0001216_abnormal_epidermal_layer1.26427354
53MP0004883_abnormal_blood_vessel1.22728202
54MP0005083_abnormal_biliary_tract1.22621471
55MP0003878_abnormal_ear_physiology1.22117134
56MP0005377_hearing/vestibular/ear_phenot1.22117134
57MP0002118_abnormal_lipid_homeostasis1.21551004
58MP0005164_abnormal_response_to1.20103090
59MP0001873_stomach_inflammation1.18513685
60MP0005376_homeostasis/metabolism_phenot1.16665992
61MP0005266_abnormal_metabolism1.16517258
62MP0006035_abnormal_mitochondrial_morpho1.14200329
63MP0003123_paternal_imprinting1.14059981
64MP0000678_abnormal_parathyroid_gland1.13491605
65MP0002127_abnormal_cardiovascular_syste1.12138654
66MP0000579_abnormal_nail_morphology1.10927943
67* MP0008872_abnormal_physiological_respon1.07822865
68MP0004381_abnormal_hair_follicle1.07202073
69MP0002089_abnormal_postnatal_growth/wei1.06403827
70MP0008260_abnormal_autophagy1.04727179
71MP0003693_abnormal_embryo_hatching1.02890115
72MP0001849_ear_inflammation1.02660309
73MP0005023_abnormal_wound_healing0.99408817
74MP0000858_altered_metastatic_potential0.99100125
75MP0006292_abnormal_olfactory_placode0.98479658
76MP0004043_abnormal_pH_regulation0.98457646
77MP0009643_abnormal_urine_homeostasis0.97642779
78* MP0000598_abnormal_liver_morphology0.95625766
79MP0001881_abnormal_mammary_gland0.95319064
80MP0005584_abnormal_enzyme/coenzyme_acti0.93451977
81MP0000249_abnormal_blood_vessel0.93423706
82MP0005075_abnormal_melanosome_morpholog0.92894944
83MP0010771_integument_phenotype0.92280903
84MP0001879_abnormal_lymphatic_vessel0.91032726
85MP0001958_emphysema0.90660095
86MP0005636_abnormal_mineral_homeostasis0.89097707
87MP0000462_abnormal_digestive_system0.88099324
88MP0003195_calcinosis0.87548285
89MP0006138_congestive_heart_failure0.86738178
90MP0002796_impaired_skin_barrier0.86664767
91MP0000767_abnormal_smooth_muscle0.85815946
92MP0005248_abnormal_Harderian_gland0.84419495
93MP0005257_abnormal_intraocular_pressure0.83686838
94MP0002060_abnormal_skin_morphology0.83581994
95MP0004272_abnormal_basement_membrane0.82756013
96MP0003866_abnormal_defecation0.82709609
97* MP0008874_decreased_physiological_sensi0.82014280
98MP0005666_abnormal_adipose_tissue0.81805628
99MP0009672_abnormal_birth_weight0.81675557
100MP0010030_abnormal_orbit_morphology0.81601203
101MP0006082_CNS_inflammation0.81380266
102MP0002877_abnormal_melanocyte_morpholog0.80546605
103MP0002249_abnormal_larynx_morphology0.76342362
104MP0003566_abnormal_cell_adhesion0.75639700
105MP0003936_abnormal_reproductive_system0.75423872
106MP0001177_atelectasis0.75353851
107MP0003868_abnormal_feces_composition0.74338085
108MP0000343_altered_response_to0.74081355
109MP0009053_abnormal_anal_canal0.73369391
110MP0001765_abnormal_ion_homeostasis0.72715993
111MP0002088_abnormal_embryonic_growth/wei0.71927849
112MP0003122_maternal_imprinting0.71199421
113MP0009931_abnormal_skin_appearance0.70728672
114MP0000647_abnormal_sebaceous_gland0.70364403
115MP0002086_abnormal_extraembryonic_tissu0.70309326
116MP0002653_abnormal_ependyma_morphology0.69572516
117MP0003984_embryonic_growth_retardation0.69406552
118MP0003638_abnormal_response/metabolism_0.69358694
119MP0005375_adipose_tissue_phenotype0.69308411
120MP0002925_abnormal_cardiovascular_devel0.68429814
121MP0004185_abnormal_adipocyte_glucose0.67025505
122MP0005670_abnormal_white_adipose0.66876128
123MP0003828_pulmonary_edema0.65996919
124MP0000367_abnormal_coat/_hair0.65818540
125MP0002876_abnormal_thyroid_physiology0.65481120
126MP0003115_abnormal_respiratory_system0.65411840
127MP0010234_abnormal_vibrissa_follicle0.65378902
128MP0005165_increased_susceptibility_to0.64576842
129MP0000003_abnormal_adipose_tissue0.64425521
130MP0005380_embryogenesis_phenotype0.64024424
131MP0001672_abnormal_embryogenesis/_devel0.64024424
132MP0001730_embryonic_growth_arrest0.63684894
133MP0005395_other_phenotype0.62449803
134MP0001340_abnormal_eyelid_morphology0.61812139
135MP0002970_abnormal_white_adipose0.59947047
136MP0003186_abnormal_redox_activity0.59743739
137MP0003656_abnormal_erythrocyte_physiolo0.57945591
138MP0003075_altered_response_to0.56195164
139MP0003119_abnormal_digestive_system0.56004524
140* MP0009765_abnormal_xenobiotic_induced0.54865745
141MP0002098_abnormal_vibrissa_morphology0.54509594
142MP0009115_abnormal_fat_cell0.53579921
143MP0002133_abnormal_respiratory_system0.53422976
144MP0005388_respiratory_system_phenotype0.53422976
145MP0006036_abnormal_mitochondrial_physio0.52681342
146* MP0008873_increased_physiological_sensi0.52414944
147* MP0009764_decreased_sensitivity_to0.52005115
148MP0000762_abnormal_tongue_morphology0.51868101
149MP0001764_abnormal_homeostasis0.51867551
150MP0009763_increased_sensitivity_to0.50745760
151MP0003950_abnormal_plasma_membrane0.50192305
152MP0001614_abnormal_blood_vessel0.49912761
153MP0002092_abnormal_eye_morphology0.47798466
154* MP0008469_abnormal_protein_level0.44681975
155MP0002128_abnormal_blood_circulation0.43775972
156MP0002932_abnormal_joint_morphology0.42871155

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.49510448
2Hypobetalipoproteinemia (HP:0003563)5.12580794
3Bilateral microphthalmos (HP:0007633)5.06494452
4Hypochromic microcytic anemia (HP:0004840)5.06099306
5Polycythemia (HP:0001901)4.62810937
6Hepatoblastoma (HP:0002884)4.48073051
7J-shaped sella turcica (HP:0002680)4.45531580
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.44214888
9Intrahepatic cholestasis (HP:0001406)4.19169668
10Xanthomatosis (HP:0000991)4.13353395
11Malnutrition (HP:0004395)4.03708541
12Asymmetry of the thorax (HP:0001555)4.01958964
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.95469133
14Vascular calcification (HP:0004934)3.88776298
15Abnormality of the intrinsic pathway (HP:0010989)3.86718488
16Multiple enchondromatosis (HP:0005701)3.84590601
17Abnormal cartilage morphology (HP:0002763)3.73306717
18Septate vagina (HP:0001153)3.72728221
19Abnormality of the lower motor neuron (HP:0002366)3.69917123
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.69085539
21Skin nodule (HP:0200036)3.59010593
22Hypolipoproteinemia (HP:0010981)3.58009157
23Hyperglycinuria (HP:0003108)3.49233746
24Shawl scrotum (HP:0000049)3.36327540
25Cardiovascular calcification (HP:0011915)3.30693801
26Hyperacusis (HP:0010780)3.28669443
27Abnormality of the nasal mucosa (HP:0000433)3.25294588
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.24971961
29Buphthalmos (HP:0000557)3.24663716
30Distal lower limb muscle weakness (HP:0009053)3.16165476
31Hyperinsulinemic hypoglycemia (HP:0000825)3.13947465
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.11139910
33Hyperlipoproteinemia (HP:0010980)3.09839745
34Epidermoid cyst (HP:0200040)3.07635037
35Lip pit (HP:0100267)2.99566403
36Microglossia (HP:0000171)2.95333583
37Hyperactive renin-angiotensin system (HP:0000841)2.91141418
38Prolonged partial thromboplastin time (HP:0003645)2.86253144
39Esophageal varix (HP:0002040)2.83541674
40Visceral angiomatosis (HP:0100761)2.82041010
41Rhinitis (HP:0012384)2.81554976
42Abnormal respiratory motile cilium physiology (HP:0012261)2.78625220
43Spontaneous hematomas (HP:0007420)2.78506024
44Abnormality of glycine metabolism (HP:0010895)2.77616787
45Abnormality of serine family amino acid metabolism (HP:0010894)2.77616787
46Vertebral compression fractures (HP:0002953)2.77385971
47Right ventricular cardiomyopathy (HP:0011663)2.76808900
48Hyperammonemia (HP:0001987)2.76330162
49Abnormal respiratory motile cilium morphology (HP:0005938)2.75794762
50Abnormal respiratory epithelium morphology (HP:0012253)2.75794762
51Micronodular cirrhosis (HP:0001413)2.73839277
52Prolonged neonatal jaundice (HP:0006579)2.72742174
53Hypoalphalipoproteinemia (HP:0003233)2.72278114
54Abdominal distention (HP:0003270)2.67312147
55Hyperphosphatemia (HP:0002905)2.64944110
56Ragged-red muscle fibers (HP:0003200)2.61390163
57Rib fusion (HP:0000902)2.61313050
58Hemorrhage of the eye (HP:0011885)2.60855639
59Absent frontal sinuses (HP:0002688)2.59750223
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.59300458
61Abnormality of the pulmonary veins (HP:0011718)2.59198247
62Hemangiomatosis (HP:0007461)2.58928462
63Hypercholesterolemia (HP:0003124)2.57226918
64Joint hemorrhage (HP:0005261)2.54798859
65Fat malabsorption (HP:0002630)2.54624411
66Gout (HP:0001997)2.54080804
67Curly hair (HP:0002212)2.51998049
68Vaginal fistula (HP:0004320)2.48824504
69Abnormality of the frontal sinuses (HP:0002687)2.46408446
70Amyloidosis (HP:0011034)2.45309163
71Congenital glaucoma (HP:0001087)2.44443751
72Hyperventilation (HP:0002883)2.44223858
73Abnormal ciliary motility (HP:0012262)2.43485214
74Back pain (HP:0003418)2.42132928
75Ketosis (HP:0001946)2.40456685
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.39693451
77Absent/shortened dynein arms (HP:0200106)2.39693451
78Abnormality of purine metabolism (HP:0004352)2.39586254
79Tetraplegia (HP:0002445)2.34513788
80Abnormality of the dental root (HP:0006486)2.34008500
81Taurodontia (HP:0000679)2.34008500
82Abnormality of permanent molar morphology (HP:0011071)2.34008500
83Metabolic acidosis (HP:0001942)2.33699195
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33593472
85Increased connective tissue (HP:0009025)2.33174359
86Amelogenesis imperfecta (HP:0000705)2.32710875
87Flat acetabular roof (HP:0003180)2.30696713
88Abnormality of nucleobase metabolism (HP:0010932)2.29493753
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.27985268
90Ulnar bowing (HP:0003031)2.27207770
91Abnormality of the distal phalanges of the toes (HP:0010182)2.25684480
92Pseudobulbar signs (HP:0002200)2.25204427
93Deformed sella turcica (HP:0002681)2.22606023
94Tetraparesis (HP:0002273)2.22024515
95Partial duplication of thumb phalanx (HP:0009944)2.22009497
96Ileus (HP:0002595)2.21464183
97Renal duplication (HP:0000075)2.20722066
98Steatorrhea (HP:0002570)2.19939874
99Hematochezia (HP:0002573)2.19382845
100Reticulocytosis (HP:0001923)2.18948723
101Complement deficiency (HP:0004431)2.17916262
102Overriding aorta (HP:0002623)2.16614726
103Testicular atrophy (HP:0000029)2.16511716
104Abnormality of molar (HP:0011077)2.15999773
105Abnormality of molar morphology (HP:0011070)2.15999773
106Ependymoma (HP:0002888)2.14620172
107Microcytic anemia (HP:0001935)2.14521645
108Peritonitis (HP:0002586)2.12642783
109Abnormality of pyrimidine metabolism (HP:0004353)2.09308751
110Abnormality of the gastric mucosa (HP:0004295)2.09078732
111Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08820935
112Cardiomegaly (HP:0001640)2.08728483
113Abnormal hemoglobin (HP:0011902)2.08332651
114Thin bony cortex (HP:0002753)2.08206652
115Abnormal gallbladder physiology (HP:0012438)2.07428565
116Cholecystitis (HP:0001082)2.07428565
117Acanthocytosis (HP:0001927)2.07264257
118Pili torti (HP:0003777)2.07008537
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.05291931
120Short humerus (HP:0005792)2.04816476
121Hypoparathyroidism (HP:0000829)2.03842631
122Widely patent fontanelles and sutures (HP:0004492)2.01897191
123Abnormality of the dental pulp (HP:0006479)2.00530587
124Bifid scrotum (HP:0000048)2.00322869
125Hyperparathyroidism (HP:0000843)1.99408076
126Short nail (HP:0001799)1.98540779
127Advanced eruption of teeth (HP:0006288)1.96703641
128Concave nail (HP:0001598)1.96584736
129Hydroxyprolinuria (HP:0003080)1.96210727
130Abnormality of proline metabolism (HP:0010907)1.96210727
131Hypochromic anemia (HP:0001931)1.95599496
132Conjunctival telangiectasia (HP:0000524)1.94927928
133Long toe (HP:0010511)1.94020150
134Abnormality of the salivary glands (HP:0010286)1.93067848
135Reduced antithrombin III activity (HP:0001976)1.91494234
136Aplasia/hypoplasia of the humerus (HP:0006507)1.91352874
137Mildly elevated creatine phosphokinase (HP:0008180)1.91074910
138Lymphangioma (HP:0100764)1.90970677
139Vacuolated lymphocytes (HP:0001922)1.90776035
140Neoplasm of striated muscle (HP:0009728)1.90548423
141Sparse lateral eyebrow (HP:0005338)1.90497284
142Achilles tendon contracture (HP:0001771)1.89697010
143Fused cervical vertebrae (HP:0002949)1.89349248
144Chronic bronchitis (HP:0004469)1.89070286
145Conjugated hyperbilirubinemia (HP:0002908)1.88563712
146Anomalous pulmonary venous return (HP:0010772)1.88355577
147Abnormality of the common coagulation pathway (HP:0010990)1.88194241
148Partial duplication of the phalanx of hand (HP:0009999)1.88153219
149Renal tubular acidosis (HP:0001947)1.86294831
150Abnormal hair laboratory examination (HP:0003328)1.85860021
151Bronchiectasis (HP:0002110)1.85752995
152Nasal polyposis (HP:0100582)1.85722185
153Hyperbilirubinemia (HP:0002904)1.85520458
154Spastic diplegia (HP:0001264)1.84826024
155Status epilepticus (HP:0002133)1.84764064
156Rectal fistula (HP:0100590)1.84233600
157Rectovaginal fistula (HP:0000143)1.84233600
158Elevated alkaline phosphatase (HP:0003155)1.83228570
159Urinary glycosaminoglycan excretion (HP:0003541)1.82613451
160Mucopolysacchariduria (HP:0008155)1.82613451
161Glomerulonephritis (HP:0000099)1.82531704
162Nephrolithiasis (HP:0000787)1.82045912
163Ketoacidosis (HP:0001993)1.80568474
164Mitral stenosis (HP:0001718)1.80486395
165Male infertility (HP:0003251)1.79758647
166Abnormality of the Achilles tendon (HP:0005109)1.79080642
167Delayed CNS myelination (HP:0002188)1.76949311
168Abnormality of methionine metabolism (HP:0010901)1.76893692
169Rickets (HP:0002748)1.76460924
170Camptodactyly of toe (HP:0001836)1.75994537
171Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.75666443
172Upper motor neuron abnormality (HP:0002127)1.75630465
173Abnormality of fatty-acid metabolism (HP:0004359)1.75483102
174Breast carcinoma (HP:0003002)1.74922043
175Rhabdomyosarcoma (HP:0002859)1.74197260
176Abnormality of complement system (HP:0005339)1.74170373
177Sensory axonal neuropathy (HP:0003390)1.73085673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.12916801
2ERN15.48491638
3GRK54.36653201
4GRK64.36449784
5TIE13.72707832
6TGFBR23.59691491
7GRK13.42382604
8RPS6KB23.03538131
9AKT32.86348221
10SMG12.81987306
11MAPKAPK32.74628661
12SCYL22.61684688
13PBK2.44284801
14TYRO32.31825352
15STK102.28558977
16MAP3K122.28491132
17TESK12.16829747
18CSF1R2.14889686
19PIK3CA2.14607891
20EIF2AK12.14170353
21NME22.10621879
22ADRBK22.09463854
23MATK2.00116683
24PRKG21.88090350
25MAPK71.82736381
26NEK61.81758651
27LMTK21.71019661
28RIPK11.69772564
29GRK71.67597802
30EPHA21.64514745
31IRAK31.52234964
32MAP2K41.46468610
33MOS1.38448987
34MAP3K101.34320779
35FGFR31.32499656
36TTK1.31271804
37PAK41.29200578
38MAPK151.28577132
39CSK1.27061629
40STK381.21305897
41TESK21.20169386
42MAP3K71.18995106
43WNK11.17519872
44NTRK11.17436289
45PDGFRA1.16764892
46CAMK41.16697369
47EEF2K1.12705055
48FGFR41.11799596
49MARK21.08044017
50SIK31.02622443
51MAP3K90.98050929
52MST40.97027853
53NME10.95082446
54EPHB10.90234435
55MAP2K60.87856896
56ADRBK10.86771012
57MAPK120.86692172
58TBK10.86506916
59CHUK0.83816661
60PTK20.80683981
61LATS10.80444728
62BCKDK0.79541069
63SIK10.78700941
64ILK0.77615046
65CAMK2G0.75983479
66LATS20.75858575
67PTK60.74828342
68MAP2K10.74585057
69CDK70.73546841
70MST1R0.72734942
71TRIB30.72686917
72EPHB20.71780373
73FRK0.71278119
74MUSK0.67182014
75HIPK20.63979074
76BMX0.62866506
77MAP3K10.58497833
78DDR20.58473115
79PIM20.57856234
80MAP2K30.57052403
81LIMK10.56837134
82MAP3K30.56548810
83CDK90.55150929
84TAOK10.54320711
85KDR0.53738373
86IGF1R0.53269915
87CDK80.49822239
88AKT20.48852730
89MET0.48572903
90VRK20.48471372
91ARAF0.48221689
92PRKD10.47477946
93RPS6KA20.46190464
94PKN20.45294712
95FGFR20.45055325
96ERBB20.44928542
97BRSK10.44896623
98MAPK40.44432711
99GSK3A0.44212225
100ALK0.43525740
101ITK0.43319792
102CAMK2B0.43300575
103CDK60.42373211
104MTOR0.42074780
105STK160.41854319
106DYRK1B0.40017716
107RET0.38794395
108PDPK10.36802290
109MAP3K80.35597239
110EIF2AK30.34956355
111PRKAA20.34793257
112MAP3K60.34617015
113PRKACG0.34565143
114NEK10.33755419
115PRKCH0.33745672
116ICK0.33335824
117PRKD20.33162452
118EGFR0.33086365
119MELK0.33086227
120FER0.32283395
121DAPK10.31328168
122PDK10.31271481
123LRRK20.30799522
124TRPM70.30777037
125RPS6KB10.30331318
126JAK20.29942670
127MAP3K20.29700129
128TAOK20.29698621
129MAPKAPK20.29676131
130AURKA0.29521537
131KSR20.28914717
132CAMK2D0.28739375
133PAK30.28210564
134YES10.28018261
135SRC0.27601953
136MAP3K110.27571528
137ERBB40.26272349
138PRKCI0.25424317
139PRKCD0.24343968
140STK38L0.24314154
141CDC42BPA0.23543755
142MAPK110.23393713
143TGFBR10.23314961
144PRPF4B0.22924088
145ABL20.22524879
146PDK20.22492861
147INSR0.22462703
148MAP2K20.22114690
149PAK20.22084193
150PDGFRB0.20753935
151MYLK0.19492950
152INSRR0.18067277
153PRKAA10.17393494
154CHEK20.16893023
155KIT0.16826006
156EIF2AK20.16239462
157PTK2B0.15145369

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002329.44224173
2* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.07385110
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04235936
4* Tryptophan metabolism_Homo sapiens_hsa003802.90635780
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.83915780
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.58365583
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.57880628
8* Chemical carcinogenesis_Homo sapiens_hsa052042.50892844
9* Steroid hormone biosynthesis_Homo sapiens_hsa001402.33913335
10Nitrogen metabolism_Homo sapiens_hsa009102.11889270
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04818467
12Arginine biosynthesis_Homo sapiens_hsa002202.03168076
13Vitamin B6 metabolism_Homo sapiens_hsa007501.99254803
14* Retinol metabolism_Homo sapiens_hsa008301.97685009
15Fat digestion and absorption_Homo sapiens_hsa049751.69173143
16Complement and coagulation cascades_Homo sapiens_hsa046101.67569247
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.65785809
18Starch and sucrose metabolism_Homo sapiens_hsa005001.58575994
19Bile secretion_Homo sapiens_hsa049761.57763522
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56218097
21Linoleic acid metabolism_Homo sapiens_hsa005911.52743096
22Other glycan degradation_Homo sapiens_hsa005111.47486251
23Galactose metabolism_Homo sapiens_hsa000521.42981987
24PPAR signaling pathway_Homo sapiens_hsa033201.42933406
25Fructose and mannose metabolism_Homo sapiens_hsa000511.36695381
26Histidine metabolism_Homo sapiens_hsa003401.35298623
27Fatty acid degradation_Homo sapiens_hsa000711.34603296
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28889610
29Renin-angiotensin system_Homo sapiens_hsa046141.17527645
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16072395
31Selenocompound metabolism_Homo sapiens_hsa004501.11961737
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10356683
33Folate biosynthesis_Homo sapiens_hsa007901.08240564
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05481147
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05457187
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05229305
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04425113
38Vitamin digestion and absorption_Homo sapiens_hsa049771.01851735
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00527575
40Peroxisome_Homo sapiens_hsa041461.00309124
41Vibrio cholerae infection_Homo sapiens_hsa051100.98410678
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94569267
43Endometrial cancer_Homo sapiens_hsa052130.92609324
44beta-Alanine metabolism_Homo sapiens_hsa004100.92585862
45Butanoate metabolism_Homo sapiens_hsa006500.87984327
46Sphingolipid metabolism_Homo sapiens_hsa006000.86894448
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84534443
48ABC transporters_Homo sapiens_hsa020100.83845059
49Hepatitis C_Homo sapiens_hsa051600.78851152
50Proteasome_Homo sapiens_hsa030500.78349186
51N-Glycan biosynthesis_Homo sapiens_hsa005100.77305586
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76906030
53Acute myeloid leukemia_Homo sapiens_hsa052210.74194412
54Phenylalanine metabolism_Homo sapiens_hsa003600.72400883
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71211460
56Glutathione metabolism_Homo sapiens_hsa004800.70895081
57Sulfur metabolism_Homo sapiens_hsa009200.68007006
58Arginine and proline metabolism_Homo sapiens_hsa003300.67997431
59Biosynthesis of amino acids_Homo sapiens_hsa012300.67730206
60Carbon metabolism_Homo sapiens_hsa012000.67681954
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66416435
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65932385
63Glycerolipid metabolism_Homo sapiens_hsa005610.65840876
64Fatty acid metabolism_Homo sapiens_hsa012120.62772394
65Insulin signaling pathway_Homo sapiens_hsa049100.62613721
66Staphylococcus aureus infection_Homo sapiens_hsa051500.60157895
67Pyruvate metabolism_Homo sapiens_hsa006200.59639582
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.58394690
69Prion diseases_Homo sapiens_hsa050200.56779434
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.56455038
71Renal cell carcinoma_Homo sapiens_hsa052110.55957903
72Tyrosine metabolism_Homo sapiens_hsa003500.53309375
73Propanoate metabolism_Homo sapiens_hsa006400.52570911
74Protein digestion and absorption_Homo sapiens_hsa049740.52351421
75Mineral absorption_Homo sapiens_hsa049780.51500208
76Lysine degradation_Homo sapiens_hsa003100.50817292
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50766907
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49088977
79Chronic myeloid leukemia_Homo sapiens_hsa052200.48200463
80Lysosome_Homo sapiens_hsa041420.48156167
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48079898
82Pentose phosphate pathway_Homo sapiens_hsa000300.47989982
83Arachidonic acid metabolism_Homo sapiens_hsa005900.46199633
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45388584
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43675329
86ErbB signaling pathway_Homo sapiens_hsa040120.42788860
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42391505
88Sulfur relay system_Homo sapiens_hsa041220.41489933
89Non-small cell lung cancer_Homo sapiens_hsa052230.39590438
90Prostate cancer_Homo sapiens_hsa052150.38131212
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35770235
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34948261
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34652388
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.33982555
95* Ovarian steroidogenesis_Homo sapiens_hsa049130.32543654
96Pancreatic cancer_Homo sapiens_hsa052120.31980092
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30791146
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27870336
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27075306
100Choline metabolism in cancer_Homo sapiens_hsa052310.26615155
101Fatty acid elongation_Homo sapiens_hsa000620.24925255
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.24549455
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23043887
104Thyroid cancer_Homo sapiens_hsa052160.22383733
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22112898
106Insulin resistance_Homo sapiens_hsa049310.22093124
107* Metabolic pathways_Homo sapiens_hsa011000.21425777
108Steroid biosynthesis_Homo sapiens_hsa001000.20996440
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20634752
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17194715
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.16004289
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15785589
113African trypanosomiasis_Homo sapiens_hsa051430.11934257
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.11708747
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10245506
116One carbon pool by folate_Homo sapiens_hsa006700.10189308
117Bladder cancer_Homo sapiens_hsa052190.09526228
118mTOR signaling pathway_Homo sapiens_hsa041500.08008523
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.07454996
120AMPK signaling pathway_Homo sapiens_hsa041520.06818203
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05674630
122Rap1 signaling pathway_Homo sapiens_hsa040150.04593857
123Adherens junction_Homo sapiens_hsa045200.04387527
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.03472847
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.02315051
126Ether lipid metabolism_Homo sapiens_hsa005650.00792344
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.00416021
128Tight junction_Homo sapiens_hsa04530-0.0110489
129Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0107077

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »