CYP11B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1progesterone metabolic process (GO:0042448)9.69750831
2cellular response to interferon-alpha (GO:0035457)9.52333933
3response to follicle-stimulating hormone (GO:0032354)9.25358617
4androgen metabolic process (GO:0008209)8.64216049
5* hormone biosynthetic process (GO:0042446)8.48412343
6cellular response to growth hormone stimulus (GO:0071378)8.42791174
7* ketone biosynthetic process (GO:0042181)7.66301639
8adhesion of symbiont to host (GO:0044406)7.62653494
9cellular response to epinephrine stimulus (GO:0071872)7.33862819
10cellular response to antibiotic (GO:0071236)7.22019548
11toxin metabolic process (GO:0009404)7.10767108
12estrogen metabolic process (GO:0008210)7.03993905
13response to lead ion (GO:0010288)6.60927397
14low-density lipoprotein particle clearance (GO:0034383)6.25556098
15response to epinephrine (GO:0071871)6.01152485
16negative regulation of cytosolic calcium ion concentration (GO:0051481)5.72736659
17phagocytosis, recognition (GO:0006910)5.45730060
18cellular response to gonadotropin stimulus (GO:0071371)5.42510347
19response to leptin (GO:0044321)5.35293852
20cellular response to toxic substance (GO:0097237)5.14007264
21positive regulation of triglyceride biosynthetic process (GO:0010867)4.81428345
22mating behavior (GO:0007617)4.75074720
23regulation of male gonad development (GO:2000018)4.65078492
24cytokine metabolic process (GO:0042107)4.63489430
25benzene-containing compound metabolic process (GO:0042537)4.58987653
26cellular response to dexamethasone stimulus (GO:0071549)4.44390805
27response to growth hormone (GO:0060416)4.43823476
28intracellular lipid transport (GO:0032365)4.36088372
29positive regulation of male gonad development (GO:2000020)4.34811906
30sterol catabolic process (GO:0016127)4.31459323
31cholesterol catabolic process (GO:0006707)4.31459323
32response to corticosterone (GO:0051412)4.27641856
33alpha-linolenic acid metabolic process (GO:0036109)4.24115250
34response to interferon-alpha (GO:0035455)4.21463297
35response to dexamethasone (GO:0071548)4.18896978
36NADP metabolic process (GO:0006739)4.06719648
37positive regulation of nitric-oxide synthase activity (GO:0051000)4.06340956
38* steroid biosynthetic process (GO:0006694)4.02513043
39detection of molecule of bacterial origin (GO:0032490)3.90198449
40response to gonadotropin (GO:0034698)3.88170569
41cellular response to catecholamine stimulus (GO:0071870)3.80869279
42cellular response to monoamine stimulus (GO:0071868)3.80869279
43* cellular hormone metabolic process (GO:0034754)3.76977210
44catecholamine biosynthetic process (GO:0042423)3.75586176
45catechol-containing compound biosynthetic process (GO:0009713)3.75586176
46circadian sleep/wake cycle process (GO:0022410)3.69777460
47linoleic acid metabolic process (GO:0043651)3.64681669
48bile acid biosynthetic process (GO:0006699)3.63580239
49regulation of cholesterol storage (GO:0010885)3.63295720
50positive regulation of vascular permeability (GO:0043117)3.61390953
51positive regulation of triglyceride metabolic process (GO:0090208)3.51997577
52regulation of triglyceride biosynthetic process (GO:0010866)3.47525918
53response to mineralocorticoid (GO:0051385)3.45884677
54* cellular ketone metabolic process (GO:0042180)3.44424936
55regulation of female gonad development (GO:2000194)3.43748481
56response to cadmium ion (GO:0046686)3.41714970
57high-density lipoprotein particle remodeling (GO:0034375)3.37292164
58response to insecticide (GO:0017085)3.27874847
59response to monoamine (GO:0071867)3.22738546
60response to catecholamine (GO:0071869)3.22738546
61response to phenylpropanoid (GO:0080184)3.22709103
62sterol transport (GO:0015918)3.02114509
63cholesterol transport (GO:0030301)3.02114509
64reverse cholesterol transport (GO:0043691)2.92909336
65* sterol metabolic process (GO:0016125)2.89462182
66regulation of steroid biosynthetic process (GO:0050810)2.88000888
67circadian behavior (GO:0048512)2.86445212
68multicellular organismal aging (GO:0010259)2.75952206
69receptor guanylyl cyclase signaling pathway (GO:0007168)2.74829180
70plasma lipoprotein particle clearance (GO:0034381)2.72019102
71secondary metabolic process (GO:0019748)2.68584777
72blood vessel endothelial cell migration (GO:0043534)2.65033606
73cholesterol metabolic process (GO:0008203)2.64438767
74Leydig cell differentiation (GO:0033327)2.62183849
75rhythmic behavior (GO:0007622)2.61349970
76response to vitamin E (GO:0033197)2.57829355
77* hormone metabolic process (GO:0042445)2.55632060
78vitamin D metabolic process (GO:0042359)2.52546684
79positive regulation of monooxygenase activity (GO:0032770)2.49606426
80* cellular response to metal ion (GO:0071248)2.48138276
81cochlea development (GO:0090102)2.47621302
82regulation of triglyceride metabolic process (GO:0090207)2.46610065
83cholesterol efflux (GO:0033344)2.44757094
84cellular response to ketone (GO:1901655)2.41713628
85positive regulation of lipid storage (GO:0010884)2.38312569
86catecholamine metabolic process (GO:0006584)2.35627503
87catechol-containing compound metabolic process (GO:0009712)2.35627503
88maintenance of protein location in nucleus (GO:0051457)2.34035741
89cellular response to cAMP (GO:0071320)2.31451495
90regulation of cholesterol biosynthetic process (GO:0045540)2.25544751
91phenol-containing compound catabolic process (GO:0019336)2.24148895
92* C21-steroid hormone biosynthetic process (GO:0006700)18.8923584
93androgen biosynthetic process (GO:0006702)16.2170070
94estrogen biosynthetic process (GO:0006703)15.7593541
95cellular response to cadmium ion (GO:0071276)14.1138758
96* glucocorticoid biosynthetic process (GO:0006704)12.7838564
97cellular response to follicle-stimulating hormone stimulus (GO:0071372)12.5295794
98* glucocorticoid metabolic process (GO:0008211)12.1508084
99* C21-steroid hormone metabolic process (GO:0008207)11.2511850
100cellular response to zinc ion (GO:0071294)10.6207484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.13216366
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.11912684
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.07798878
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.33832197
5ESR1_15608294_ChIP-ChIP_MCF-7_Human3.33008735
6CLOCK_20551151_ChIP-Seq_293T_Human3.25322868
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.14989198
8SRY_22984422_ChIP-ChIP_TESTIS_Rat3.08999416
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.05590080
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.03592930
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39663158
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39663158
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.08362281
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.03072972
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02125859
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01846761
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.01307332
18LXR_22292898_ChIP-Seq_THP-1_Human1.99633755
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98902400
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97013788
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.94124429
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93741442
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93004479
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.89386288
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.89125383
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88533789
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83836830
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82297785
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82202487
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.75805305
31NFIB_24661679_ChIP-Seq_LUNG_Mouse1.73599601
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73314117
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70980956
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70321143
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70086402
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.66732311
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64627602
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64397576
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61712830
40EGR1_19032775_ChIP-ChIP_M12_Human1.53268430
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53125974
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51826473
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50024826
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46040433
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42464960
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40807977
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40589662
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40589662
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40338572
50KDM2B_26808549_Chip-Seq_K562_Human1.37534176
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36491779
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.32163165
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.30156573
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28244565
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22917425
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.21263566
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19864405
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17599182
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17093603
60KDM2B_26808549_Chip-Seq_DND41_Human1.16908965
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16642491
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16432345
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.12912325
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.12583642
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09954379
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.06834871
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05862961
68ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05533392
69* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05493498
70CTCF_27219007_Chip-Seq_Bcells_Human1.03994124
71RACK7_27058665_Chip-Seq_MCF-7_Human0.99719644
72CBX2_27304074_Chip-Seq_ESCs_Mouse0.96833991
73P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96431236
74ELK3_25401928_ChIP-Seq_HUVEC_Human0.96250431
75HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96051373
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94323835
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94309913
78ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91443461
79STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91374082
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90420185
81GF1_26923725_Chip-Seq_HPCs_Mouse0.90379507
82* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89317776
83STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89194539
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87637476
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85776567
86WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84167686
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83503030
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82246755
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81655287
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80789094
91TBX20_22328084_ChIP-Seq_HEART_Mouse0.80319059
92TBX20_22080862_ChIP-Seq_HEART_Mouse0.80319059
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80271076
94P68_20966046_ChIP-Seq_HELA_Human0.78935013
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76898309
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.76811516
97DROSHA_22980978_ChIP-Seq_HELA_Human0.76352106
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76161353
99POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75401598
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.74563326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002909_abnormal_adrenal_gland9.49321910
2* MP0000639_abnormal_adrenal_gland8.04437395
3MP0002822_catalepsy4.72499705
4* MP0001765_abnormal_ion_homeostasis3.85794679
5MP0008875_abnormal_xenobiotic_pharmacok3.33076299
6MP0004084_abnormal_cardiac_muscle2.79873960
7* MP0000230_abnormal_systemic_arterial2.79683156
8MP0000631_abnormal_neuroendocrine_gland2.63496313
9* MP0005636_abnormal_mineral_homeostasis2.52110288
10MP0005647_abnormal_sex_gland2.42112359
11MP0004883_abnormal_blood_vessel2.39451334
12MP0004085_abnormal_heartbeat2.33553294
13MP0000566_synostosis2.32018119
14* MP0005319_abnormal_enzyme/_coenzyme2.13198623
15MP0003300_gastrointestinal_ulcer2.12393169
16MP0010329_abnormal_lipoprotein_level2.07848106
17MP0000538_abnormal_urinary_bladder1.88405527
18* MP0003953_abnormal_hormone_level1.65372539
19MP0006138_congestive_heart_failure1.62223516
20MP0004036_abnormal_muscle_relaxation1.59219113
21MP0003942_abnormal_urinary_system1.55287492
22MP0009053_abnormal_anal_canal1.44357105
23MP0008961_abnormal_basal_metabolism1.43799035
24MP0005164_abnormal_response_to1.36903382
25* MP0003638_abnormal_response/metabolism_1.25516045
26MP0000537_abnormal_urethra_morphology1.22375701
27* MP0005584_abnormal_enzyme/coenzyme_acti1.21919986
28MP0008872_abnormal_physiological_respon1.20022350
29MP0003122_maternal_imprinting1.18262280
30MP0002118_abnormal_lipid_homeostasis1.16718495
31MP0001440_abnormal_grooming_behavior1.16563276
32MP0001879_abnormal_lymphatic_vessel1.11481461
33MP0001501_abnormal_sleep_pattern1.09466887
34MP0004145_abnormal_muscle_electrophysio1.09053730
35MP0003385_abnormal_body_wall1.08671442
36MP0002078_abnormal_glucose_homeostasis1.05593700
37MP0000343_altered_response_to1.05417412
38* MP0009643_abnormal_urine_homeostasis1.04775886
39MP0003283_abnormal_digestive_organ1.03946646
40MP0005452_abnormal_adipose_tissue1.03651465
41MP0000751_myopathy1.03112552
42MP0002160_abnormal_reproductive_system1.01032074
43MP0003123_paternal_imprinting1.00292246
44MP0005503_abnormal_tendon_morphology0.97808540
45MP0009250_abnormal_appendicular_skeleto0.97608685
46MP0005595_abnormal_vascular_smooth0.95757828
47MP0005535_abnormal_body_temperature0.92393301
48MP0003948_abnormal_gas_homeostasis0.90897424
49MP0002295_abnormal_pulmonary_circulatio0.90387924
50MP0000609_abnormal_liver_physiology0.87378028
51MP0001544_abnormal_cardiovascular_syste0.86220338
52MP0005385_cardiovascular_system_phenoty0.86220338
53MP0010368_abnormal_lymphatic_system0.84707337
54MP0001119_abnormal_female_reproductive0.80029660
55* MP0010630_abnormal_cardiac_muscle0.78634588
56MP0001529_abnormal_vocalization0.78100377
57MP0008874_decreased_physiological_sensi0.77600913
58MP0003724_increased_susceptibility_to0.76742736
59MP0001177_atelectasis0.75505950
60MP0004272_abnormal_basement_membrane0.75232757
61* MP0009642_abnormal_blood_homeostasis0.74906261
62* MP0000266_abnormal_heart_morphology0.70870428
63* MP0001756_abnormal_urination0.69527470
64* MP0002069_abnormal_eating/drinking_beha0.69181876
65MP0008438_abnormal_cutaneous_collagen0.69086719
66MP0003635_abnormal_synaptic_transmissio0.67165699
67MP0003115_abnormal_respiratory_system0.65832692
68MP0004130_abnormal_muscle_cell0.65684452
69MP0008775_abnormal_heart_ventricle0.64329140
70MP0004858_abnormal_nervous_system0.64026386
71MP0002249_abnormal_larynx_morphology0.63575493
72MP0002269_muscular_atrophy0.63239413
73MP0000003_abnormal_adipose_tissue0.62063607
74MP0003091_abnormal_cell_migration0.61374833
75MP0003705_abnormal_hypodermis_morpholog0.61049064
76MP0002127_abnormal_cardiovascular_syste0.60928416
77MP0002135_abnormal_kidney_morphology0.59945481
78MP0003191_abnormal_cellular_cholesterol0.59073677
79MP0005670_abnormal_white_adipose0.58400259
80MP0000249_abnormal_blood_vessel0.58339984
81MP0005365_abnormal_bile_salt0.58123094
82* MP0008469_abnormal_protein_level0.57159451
83MP0005389_reproductive_system_phenotype0.56993608
84MP0000778_abnormal_nervous_system0.56348117
85MP0005375_adipose_tissue_phenotype0.56211452
86MP0008770_decreased_survivor_rate0.56069880
87MP0001614_abnormal_blood_vessel0.54900971
88MP0002557_abnormal_social/conspecific_i0.53288893
89MP0001348_abnormal_lacrimal_gland0.51829039
90* MP0004087_abnormal_muscle_fiber0.51720464
91MP0003755_abnormal_palate_morphology0.51011692
92MP0003566_abnormal_cell_adhesion0.50152743
93MP0000653_abnormal_sex_gland0.49080756
94MP0000703_abnormal_thymus_morphology0.48896684
95* MP0010770_preweaning_lethality0.48614739
96* MP0002082_postnatal_lethality0.48614739
97MP0002139_abnormal_hepatobiliary_system0.48316794
98* MP0010769_abnormal_survival0.48006366
99MP0000013_abnormal_adipose_tissue0.47362390
100MP0000678_abnormal_parathyroid_gland0.47052495

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the uterus (HP:0000013)8.13804629
2Aplasia/hypoplasia of the uterus (HP:0008684)7.01977036
3Sex reversal (HP:0012245)6.70565774
4Abnormal sex determination (HP:0012244)6.70565774
5* Abnormality of renin-angiotensin system (HP:0000847)6.47035815
6Adrenal overactivity (HP:0002717)5.56789563
7Bifid scrotum (HP:0000048)5.50856879
8Accelerated skeletal maturation (HP:0005616)5.30613640
9Testicular neoplasm (HP:0010788)4.80536028
10* Neonatal onset (HP:0003623)4.69281365
11Azoospermia (HP:0000027)4.66382337
12Hypokalemia (HP:0002900)4.30741982
13Clitoromegaly (HP:0000057)4.22408981
14Neonatal hypoglycemia (HP:0001998)3.54674491
15Gonadal dysgenesis (HP:0000133)3.26912874
16Abnormality of secondary sexual hair (HP:0009888)3.19397550
17Abnormality of the axillary hair (HP:0100134)3.19397550
18* Abnormality of potassium homeostasis (HP:0011042)3.06878377
19Abnormal spermatogenesis (HP:0008669)3.06132240
20Precocious puberty (HP:0000826)2.96578587
21Male pseudohermaphroditism (HP:0000037)2.95660762
22Multifactorial inheritance (HP:0001426)2.94111827
23Abnormality of the clitoris (HP:0000056)2.92198933
24Septate vagina (HP:0001153)2.75908939
25Scrotal hypoplasia (HP:0000046)2.73238927
26Shawl scrotum (HP:0000049)2.68413063
27Hypothermia (HP:0002045)2.66399319
28Facial hemangioma (HP:0000329)2.64970107
29Breast hypoplasia (HP:0003187)2.47165351
30Prolonged QT interval (HP:0001657)2.44178828
31Hypospadias (HP:0000047)2.43465805
32Aplasia of the musculature (HP:0100854)2.41189755
33Sparse lateral eyebrow (HP:0005338)2.39478237
34Premature ovarian failure (HP:0008209)2.31467272
35Abnormal hemoglobin (HP:0011902)2.22491402
36Broad alveolar ridges (HP:0000187)2.21565336
37Bifid tongue (HP:0010297)2.19725055
38Breech presentation (HP:0001623)2.19381217
39Overlapping toe (HP:0001845)2.12507160
40Lymphangioma (HP:0100764)2.11330737
41Atrioventricular block (HP:0001678)2.07966466
42Hydroxyprolinuria (HP:0003080)2.04028396
43Abnormality of proline metabolism (HP:0010907)2.04028396
44Hyperglycinuria (HP:0003108)2.02188046
45Microglossia (HP:0000171)2.01291980
46* Orthostatic hypotension (HP:0001278)2.00950979
47Decreased circulating renin level (HP:0003351)13.0579362
48Enlarged penis (HP:0000040)11.4150042
49* Renal salt wasting (HP:0000127)10.3920179
50Hyperaldosteronism (HP:0000859)10.0785149
51Coronal craniosynostosis (HP:0004440)1.97133819
52Secondary amenorrhea (HP:0000869)1.96756167
53Increased nuchal translucency (HP:0010880)1.93169487
54Absent hand (HP:0004050)1.92531524
55Syncope (HP:0001279)1.89860328
56Broad metatarsal (HP:0001783)1.81081784
57Increased number of teeth (HP:0011069)1.80799155
58Abnormality of serine family amino acid metabolism (HP:0010894)1.77159560
59Abnormality of glycine metabolism (HP:0010895)1.77159560
60Pulmonary fibrosis (HP:0002206)1.74595146
61Hypoplastic nipples (HP:0002557)1.72190648
62Generalized hypotonia (HP:0001290)1.71698465
63Ureteral stenosis (HP:0000071)1.68847525
64Ketoacidosis (HP:0001993)1.68403294
65Hyperpituitarism (HP:0010514)1.62601633
66Gastrointestinal dysmotility (HP:0002579)1.60307532
67Bicornuate uterus (HP:0000813)1.56737579
68Bronchomalacia (HP:0002780)1.49816416
69Delayed CNS myelination (HP:0002188)1.48954241
70Complement deficiency (HP:0004431)1.48532828
71Split hand (HP:0001171)1.46439544
72Colitis (HP:0002583)1.44924414
73Capillary hemangiomas (HP:0005306)1.43127075
74Ureteral obstruction (HP:0006000)1.41476036
75Supranuclear gaze palsy (HP:0000605)1.41229061
76Advanced eruption of teeth (HP:0006288)1.38699448
77Aplasia/Hypoplasia involving the musculature (HP:0001460)1.37791800
78Poor suck (HP:0002033)1.37569828
79Turricephaly (HP:0000262)1.36568885
80Hemorrhage of the eye (HP:0011885)1.36311871
81Ketosis (HP:0001946)1.33655417
82Abnormal EKG (HP:0003115)1.32698847
83Abnormality of glutamine family amino acid metabolism (HP:0010902)1.32681033
84Hyperacusis (HP:0010780)1.32533199
85Cortical visual impairment (HP:0100704)1.31461854
86Decreased testicular size (HP:0008734)1.31353358
87Hammertoe (HP:0001765)1.31047105
88Heterotopia (HP:0002282)1.28517269
89Hypercalciuria (HP:0002150)1.27843157
90Pigmentary retinal degeneration (HP:0001146)1.27106028
91Heart block (HP:0012722)1.27098391
92Rectal prolapse (HP:0002035)1.26248667
93Ovarian neoplasm (HP:0100615)1.25637499
94Buphthalmos (HP:0000557)1.25200182
95Visceral angiomatosis (HP:0100761)1.24128585
96* Primary adrenal insufficiency (HP:0008207)1.23869395
97Overriding aorta (HP:0002623)1.22440669
98Complete atrioventricular canal defect (HP:0001674)1.21684047
99Oligomenorrhea (HP:0000876)1.20991909
100Abnormality of the alveolar ridges (HP:0006477)1.19690514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.17892897
2TRIB34.05752764
3SIK14.00596104
4SIK32.95866216
5SIK22.75540472
6TAOK32.70992460
7CDK72.54744429
8EPHB22.05457381
9AKT310.3088737
10CAMK1G1.90763633
11BCKDK1.62159094
12PNCK1.57070341
13TIE11.54036782
14PKN21.53238285
15FGFR41.51754403
16FGFR21.42398572
17KDR1.27010363
18STK391.26853164
19PTK61.12347289
20RIPK11.11945206
21WNK41.06538635
22UHMK11.06455432
23CAMK1D1.05716794
24LRRK21.04973788
25BRD40.95756057
26ICK0.95144750
27TGFBR20.93151640
28MST1R0.91739618
29MARK20.84398919
30MET0.83729500
31PRKD10.83616358
32NTRK30.79955914
33NTRK10.79355026
34MAPK30.79213118
35FER0.75549438
36MAPKAPK50.75197504
37PAK40.73868577
38IRAK20.71039678
39PRKCH0.70340837
40LATS20.70046354
41RIPK40.66466985
42PAK60.66185847
43DYRK1B0.64871539
44ALK0.63576699
45KSR20.62402318
46PTK20.61366703
47DMPK0.59281678
48MAP3K10.49749109
49FGFR10.48931396
50TBK10.48702394
51EPHB10.48635627
52INSRR0.47076144
53MAPK120.46530244
54PHKG10.46102087
55PHKG20.46102087
56HIPK20.45016579
57PRKACB0.44827581
58IRAK30.44759369
59GSK3A0.44504309
60CAMK10.43490193
61CSNK1A1L0.43249360
62NTRK20.42587099
63PRKD20.42155477
64PDGFRA0.41981810
65PDPK10.40817076
66PRKACG0.40140007
67PRKACA0.40114491
68MAP3K70.39875037
69MARK30.39243775
70ILK0.39237320
71MAP2K10.39109923
72TGFBR10.37756795
73MARK10.37242769
74PRKCG0.36876768
75DYRK30.36333578
76MTOR0.34757831
77PAK30.33897458
78ERBB20.32782120
79MAP3K110.30725988
80CDK50.30569953
81CDC42BPA0.28260350
82MAPK10.27060186
83SRC0.27035706
84GRK60.26075108
85RPS6KA30.25049229
86PKN10.24834737
87MAP2K20.23766939
88CAMK40.23599614
89PRKD30.23255595
90CSNK1E0.22513117
91MINK10.22177377
92OXSR10.22020481
93RET0.21049808
94FES0.20387270
95MAPK90.20261249
96CAMKK10.20258949
97TNK20.18495072
98WNK10.18114518
99CAMK2B0.18057917
100IGF1R0.17887854

Predicted pathways (KEGG)

RankGene SetZ-score
1* Aldosterone synthesis and secretion_Homo sapiens_hsa049256.65916159
2* Steroid hormone biosynthesis_Homo sapiens_hsa001406.60818853
3Ovarian steroidogenesis_Homo sapiens_hsa049135.44480852
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.85998467
5Tyrosine metabolism_Homo sapiens_hsa003503.35538054
6Fatty acid metabolism_Homo sapiens_hsa012123.22551260
7Vitamin digestion and absorption_Homo sapiens_hsa049772.45677752
8Fatty acid degradation_Homo sapiens_hsa000712.30756784
9Fat digestion and absorption_Homo sapiens_hsa049752.30622780
10Fatty acid biosynthesis_Homo sapiens_hsa000612.27298316
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03799418
12PPAR signaling pathway_Homo sapiens_hsa033201.89931574
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86266798
14Bile secretion_Homo sapiens_hsa049761.75490075
15Propanoate metabolism_Homo sapiens_hsa006401.66113338
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.61600477
17Steroid biosynthesis_Homo sapiens_hsa001001.61033623
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38457766
19Nitrogen metabolism_Homo sapiens_hsa009101.35058910
20Renin secretion_Homo sapiens_hsa049241.34435851
21Pyruvate metabolism_Homo sapiens_hsa006201.31554131
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16361982
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16003127
24Fatty acid elongation_Homo sapiens_hsa000621.15086264
25cAMP signaling pathway_Homo sapiens_hsa040241.02782200
26Carbon metabolism_Homo sapiens_hsa012000.98993609
27Lysine degradation_Homo sapiens_hsa003100.97649131
28beta-Alanine metabolism_Homo sapiens_hsa004100.92502651
29Tryptophan metabolism_Homo sapiens_hsa003800.91802183
30Butanoate metabolism_Homo sapiens_hsa006500.88466490
31Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77008649
32Circadian entrainment_Homo sapiens_hsa047130.70473684
33Caffeine metabolism_Homo sapiens_hsa002320.69985817
34Cocaine addiction_Homo sapiens_hsa050300.67886744
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65176844
36Linoleic acid metabolism_Homo sapiens_hsa005910.63912927
37Prostate cancer_Homo sapiens_hsa052150.63899611
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.59026226
39Glycerolipid metabolism_Homo sapiens_hsa005610.56340810
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55919576
41Amphetamine addiction_Homo sapiens_hsa050310.54372212
42Insulin resistance_Homo sapiens_hsa049310.50494213
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45701254
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43868482
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43594835
46Dopaminergic synapse_Homo sapiens_hsa047280.42338021
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41903269
48Morphine addiction_Homo sapiens_hsa050320.41070932
49Peroxisome_Homo sapiens_hsa041460.37342322
50Prion diseases_Homo sapiens_hsa050200.36395467
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.35970782
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35270004
53Oxytocin signaling pathway_Homo sapiens_hsa049210.34854793
54Staphylococcus aureus infection_Homo sapiens_hsa051500.34471679
55Insulin secretion_Homo sapiens_hsa049110.33463692
56Phenylalanine metabolism_Homo sapiens_hsa003600.31307127
57Complement and coagulation cascades_Homo sapiens_hsa046100.31084749
58Histidine metabolism_Homo sapiens_hsa003400.30140693
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29997692
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.29835091
61Estrogen signaling pathway_Homo sapiens_hsa049150.27839491
62Arginine biosynthesis_Homo sapiens_hsa002200.27661055
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27226026
64Basal cell carcinoma_Homo sapiens_hsa052170.25672486
65Salivary secretion_Homo sapiens_hsa049700.25309736
66Chemical carcinogenesis_Homo sapiens_hsa052040.23837256
67Axon guidance_Homo sapiens_hsa043600.23641059
68Phagosome_Homo sapiens_hsa041450.23619301
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23264578
70Hedgehog signaling pathway_Homo sapiens_hsa043400.22670265
71Glucagon signaling pathway_Homo sapiens_hsa049220.22270424
72Melanogenesis_Homo sapiens_hsa049160.22116076
73AMPK signaling pathway_Homo sapiens_hsa041520.20264466
74Lysosome_Homo sapiens_hsa041420.19772644
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19314625
76Serotonergic synapse_Homo sapiens_hsa047260.18899666
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18775311
78Dilated cardiomyopathy_Homo sapiens_hsa054140.17856569
79Proteoglycans in cancer_Homo sapiens_hsa052050.17076823
80Focal adhesion_Homo sapiens_hsa045100.16958394
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16682564
82Biosynthesis of amino acids_Homo sapiens_hsa012300.16364191
83Cardiac muscle contraction_Homo sapiens_hsa042600.15709502
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15268575
85Sulfur metabolism_Homo sapiens_hsa009200.15115772
86Rap1 signaling pathway_Homo sapiens_hsa040150.14490962
87Circadian rhythm_Homo sapiens_hsa047100.13718374
88Hepatitis C_Homo sapiens_hsa051600.13071907
89Glutamatergic synapse_Homo sapiens_hsa047240.12683362
90Renal cell carcinoma_Homo sapiens_hsa052110.12026425
91VEGF signaling pathway_Homo sapiens_hsa043700.11717449
92Calcium signaling pathway_Homo sapiens_hsa040200.11326765
93Gastric acid secretion_Homo sapiens_hsa049710.10957494
94GABAergic synapse_Homo sapiens_hsa047270.10311796
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08814979
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.08365724
97Wnt signaling pathway_Homo sapiens_hsa043100.07696586
98Ras signaling pathway_Homo sapiens_hsa040140.07681234
99* Metabolic pathways_Homo sapiens_hsa011000.07114710
100Thyroid hormone synthesis_Homo sapiens_hsa049180.06559777

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