CYP11B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to follicle-stimulating hormone (GO:0032354)9.89573684
2cellular response to interferon-alpha (GO:0035457)9.67432009
3androgen metabolic process (GO:0008209)8.37806701
4* hormone biosynthetic process (GO:0042446)8.32444091
5cellular response to growth hormone stimulus (GO:0071378)8.19400246
6positive regulation of hormone biosynthetic process (GO:0046886)8.07996542
7estrogen metabolic process (GO:0008210)7.87530812
8cellular response to antibiotic (GO:0071236)7.86295343
9* ketone biosynthetic process (GO:0042181)7.69011546
10response to methylmercury (GO:0051597)7.39026131
11adhesion of symbiont to host (GO:0044406)7.11294391
12cellular response to epinephrine stimulus (GO:0071872)6.93437496
13toxin metabolic process (GO:0009404)6.69354125
14response to lead ion (GO:0010288)6.48800403
15positive regulation of hormone metabolic process (GO:0032352)5.94471479
16negative regulation of cytosolic calcium ion concentration (GO:0051481)5.89405169
17cellular response to gonadotropin stimulus (GO:0071371)5.80601084
18positive regulation of steroid biosynthetic process (GO:0010893)5.73959534
19cellular response to toxic substance (GO:0097237)5.73541163
20response to epinephrine (GO:0071871)5.62895051
21response to leptin (GO:0044321)5.43255264
22renal system process involved in regulation of blood volume (GO:0001977)5.37350866
23mating behavior (GO:0007617)5.35633909
24catechol-containing compound biosynthetic process (GO:0009713)5.27263556
25catecholamine biosynthetic process (GO:0042423)5.27263556
26low-density lipoprotein particle clearance (GO:0034383)5.20952975
27regulation of female receptivity (GO:0045924)5.13170877
28cytokine metabolic process (GO:0042107)5.06075405
29regulation of apoptotic cell clearance (GO:2000425)5.01319223
30renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.97276782
31benzene-containing compound metabolic process (GO:0042537)4.93137314
32phagocytosis, recognition (GO:0006910)4.91234983
33cellular response to dexamethasone stimulus (GO:0071549)4.89294862
34regulation of steroid hormone biosynthetic process (GO:0090030)4.84375160
35regulation of transmission of nerve impulse (GO:0051969)4.78463163
36adrenal gland development (GO:0030325)4.77455088
37regulation of male gonad development (GO:2000018)4.75905578
38aggressive behavior (GO:0002118)4.72829531
39positive regulation of male gonad development (GO:2000020)4.63375366
40response to dexamethasone (GO:0071548)4.59235105
41response to corticosterone (GO:0051412)4.50846520
42response to interferon-alpha (GO:0035455)4.48310583
43female mating behavior (GO:0060180)4.46474102
44response to water (GO:0009415)4.45311150
45ovulation (GO:0030728)4.35901974
46sterol catabolic process (GO:0016127)4.35495158
47cholesterol catabolic process (GO:0006707)4.35495158
48response to growth hormone (GO:0060416)4.33227992
49positive regulation of nitric-oxide synthase activity (GO:0051000)4.26964678
50positive regulation of steroid metabolic process (GO:0045940)4.26203018
51response to insecticide (GO:0017085)4.25230038
52complement activation, alternative pathway (GO:0006957)4.22369750
53response to gonadotropin (GO:0034698)4.15832916
54positive regulation of amino acid transport (GO:0051957)4.11142864
55intracellular lipid transport (GO:0032365)4.09348142
56positive regulation of systemic arterial blood pressure (GO:0003084)4.08422784
57detection of molecule of bacterial origin (GO:0032490)4.06850512
58opsonization (GO:0008228)4.06762204
59* steroid biosynthetic process (GO:0006694)3.94173154
60response to phenylpropanoid (GO:0080184)3.87526775
61potassium ion homeostasis (GO:0055075)3.83782316
62positive regulation of triglyceride biosynthetic process (GO:0010867)3.79390884
63membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.76202056
64bile acid biosynthetic process (GO:0006699)3.75178070
65regulation of complement activation (GO:0030449)3.72980696
66atrial cardiac muscle cell action potential (GO:0086014)3.67420775
67response to mineralocorticoid (GO:0051385)3.66955924
68NADP metabolic process (GO:0006739)3.64986384
69* cellular hormone metabolic process (GO:0034754)3.63489592
70cellular response to monoamine stimulus (GO:0071868)3.62204433
71cellular response to catecholamine stimulus (GO:0071870)3.62204433
72sex differentiation (GO:0007548)3.60297061
73regulation of cholesterol biosynthetic process (GO:0045540)3.56006214
74response to cadmium ion (GO:0046686)3.54125666
75circadian sleep/wake cycle process (GO:0022410)3.51562264
76* cellular ketone metabolic process (GO:0042180)3.51098120
77vitamin D metabolic process (GO:0042359)3.49789139
78cellular sodium ion homeostasis (GO:0006883)3.47712809
79regulation of protein activation cascade (GO:2000257)3.44527604
80potassium ion export (GO:0071435)3.43143269
81regulation of female gonad development (GO:2000194)3.43014381
82maternal behavior (GO:0042711)3.37628009
83Leydig cell differentiation (GO:0033327)3.37186893
84myotube differentiation (GO:0014902)3.33792436
85membrane repolarization during action potential (GO:0086011)3.29220698
86response to vitamin E (GO:0033197)3.25945111
87regulation of cholesterol storage (GO:0010885)3.22515801
88positive regulation of lipid biosynthetic process (GO:0046889)3.18900731
89positive regulation of digestive system process (GO:0060456)3.17038168
90response to antibiotic (GO:0046677)3.14045215
91alpha-linolenic acid metabolic process (GO:0036109)3.08644354
92regulation of hormone biosynthetic process (GO:0046885)3.08401358
93positive regulation of renal sodium excretion (GO:0035815)3.06240889
94parental behavior (GO:0060746)3.05757318
95response to catecholamine (GO:0071869)3.04218008
96response to monoamine (GO:0071867)3.04218008
97high-density lipoprotein particle remodeling (GO:0034375)3.01287122
98sodium ion homeostasis (GO:0055078)3.00010107
99phenol-containing compound biosynthetic process (GO:0046189)2.95230818
100regulation of glutamate secretion (GO:0014048)2.94232676
101cholesterol efflux (GO:0033344)2.92900995
102catecholamine metabolic process (GO:0006584)2.87338261
103catechol-containing compound metabolic process (GO:0009712)2.87338261
104* sterol metabolic process (GO:0016125)2.85779031
105positive regulation of fatty acid biosynthetic process (GO:0045723)2.85481288
106sterol transport (GO:0015918)2.82775998
107cholesterol transport (GO:0030301)2.82775998
108regulation of steroid metabolic process (GO:0019218)2.82559970
109regulation of systemic arterial blood pressure by hormone (GO:0001990)2.80676270
110regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.80676270
111endocrine process (GO:0050886)2.80676270
112regulation of cholesterol metabolic process (GO:0090181)2.79200666
113regulation of steroid biosynthetic process (GO:0050810)2.77773418
114cellular response to ketone (GO:1901655)2.74456858
115negative regulation of fatty acid transport (GO:2000192)2.73530261
116multicellular organismal aging (GO:0010259)2.73190733
117regulation of triglyceride biosynthetic process (GO:0010866)2.72137041
118positive regulation of monooxygenase activity (GO:0032770)2.70024703
119secondary metabolic process (GO:0019748)2.67986857
120phenol-containing compound metabolic process (GO:0018958)2.66899430
121reverse cholesterol transport (GO:0043691)2.65281774
122positive regulation of triglyceride metabolic process (GO:0090208)2.65084327
123circadian behavior (GO:0048512)2.64903240
124cochlea development (GO:0090102)2.61207468
125cholesterol metabolic process (GO:0008203)2.60264708
126linoleic acid metabolic process (GO:0043651)2.56614836
127* hormone metabolic process (GO:0042445)2.54648305
128daunorubicin metabolic process (GO:0044597)2.51687217
129doxorubicin metabolic process (GO:0044598)2.51687217
130* C21-steroid hormone biosynthetic process (GO:0006700)18.7090235
131estrogen biosynthetic process (GO:0006703)17.7254961
132androgen biosynthetic process (GO:0006702)15.3149231
133cellular response to cadmium ion (GO:0071276)14.9598572
134cellular response to follicle-stimulating hormone stimulus (GO:0071372)13.2364251
135* glucocorticoid biosynthetic process (GO:0006704)12.4537209
136* glucocorticoid metabolic process (GO:0008211)11.8298205
137cellular response to zinc ion (GO:0071294)11.4646998
138* C21-steroid hormone metabolic process (GO:0008207)11.4473861
139progesterone metabolic process (GO:0042448)10.5474206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.78422526
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.54151003
3EZH2_22144423_ChIP-Seq_EOC_Human5.09480474
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.37958259
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.07829735
6CLOCK_20551151_ChIP-Seq_293T_Human3.85545661
7SRY_22984422_ChIP-ChIP_TESTIS_Rat3.26433655
8ESR1_15608294_ChIP-ChIP_MCF-7_Human3.18656529
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.97292110
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.90390299
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83651254
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.72371244
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28037652
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.22242754
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.21058108
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20378526
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15934739
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.07573394
19NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.07351879
20NRF2_20460467_ChIP-Seq_MEFs_Mouse2.07351879
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06063419
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06063419
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.04229792
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.03741733
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99433580
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95086636
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94368033
28GBX2_23144817_ChIP-Seq_PC3_Human1.93429057
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92663120
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92255767
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86103437
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83148977
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81635107
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80765727
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.79015563
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77997833
37LXR_22292898_ChIP-Seq_THP-1_Human1.75267011
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72434757
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69082443
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67637310
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67445343
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66303372
43EGR1_19032775_ChIP-ChIP_M12_Human1.65573432
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.64154960
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.62940931
46DROSHA_22980978_ChIP-Seq_HELA_Human1.61114388
47AR_21572438_ChIP-Seq_LNCaP_Human1.52427171
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.50053097
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49408900
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43486975
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41461317
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41435246
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.40875589
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.39064449
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.38632344
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.37772227
57AR_25329375_ChIP-Seq_VCAP_Human1.37688457
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35544254
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34382309
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32687866
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30621739
62SMAD4_21799915_ChIP-Seq_A2780_Human1.30430078
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.29942791
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28839364
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27315604
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27106001
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26987812
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25824657
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.23942790
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22940532
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22007451
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20626553
73BCAT_22108803_ChIP-Seq_LS180_Human1.20556168
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20034265
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19999281
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19873817
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19231725
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16397360
79GATA1_19941826_ChIP-Seq_K562_Human1.14017212
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12817671
81VDR_24787735_ChIP-Seq_THP-1_Human1.12444228
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12203161
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11800281
84LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11732425
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.11667828
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10513820
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09261768
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08331956
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08331956
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07483298
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.06206206
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06171824
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05316666
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04554146
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03681428
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03406178
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.03397008
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00203067
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.99994122
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98650903
101SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97907599
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97056744
103GF1_26923725_Chip-Seq_HPCs_Mouse0.96391217
104AHR_22903824_ChIP-Seq_MCF-7_Human0.95005290
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94729658
106GATA4_25053715_ChIP-Seq_YYC3_Human0.93708510
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91057573
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90541314
109SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90115556
110SMAD4_21741376_ChIP-Seq_EPCs_Human0.89731835
111RNF2_27304074_Chip-Seq_ESCs_Mouse0.89292355
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88517252
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88284685
114TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87769264
115KDM2B_26808549_Chip-Seq_K562_Human0.87344964
116TP53_18474530_ChIP-ChIP_U2OS_Human0.87283880
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.86903941
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86270736
119GATA2_19941826_ChIP-Seq_K562_Human0.85550223
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85222311
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84870946
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84618492
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84451766
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84380237
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83430495
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.83103380
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.83103380
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82786640
129RXR_22108803_ChIP-Seq_LS180_Human0.82669882
130POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81514417
131TCF4_23295773_ChIP-Seq_U87_Human0.81470099
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81234037
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.80799517
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79979886
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77880141
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76742644
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75148265
138AR_19668381_ChIP-Seq_PC3_Human0.74637151
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73662414
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72778612
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.71139420
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70804481
143* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.69923346
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69405268
145MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.69174284
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.68828519
147UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.68057733
148P68_20966046_ChIP-Seq_HELA_Human0.67611624
149E2F1_20622854_ChIP-Seq_HELA_Human0.67362839
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66915366
151KDM2B_26808549_Chip-Seq_SUP-B15_Human0.66912793
152DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.66649420
153KDM2B_26808549_Chip-Seq_DND41_Human0.65519036
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.65398328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000639_abnormal_adrenal_gland8.30976373
2MP0008004_abnormal_stomach_pH6.73505156
3MP0008995_early_reproductive_senescence6.53763242
4MP0009840_abnormal_foam_cell4.46566800
5MP0002837_dystrophic_cardiac_calcinosis4.02686858
6MP0002822_catalepsy3.94252892
7* MP0001765_abnormal_ion_homeostasis3.89000179
8MP0008875_abnormal_xenobiotic_pharmacok3.68740090
9* MP0000230_abnormal_systemic_arterial3.24368998
10MP0002254_reproductive_system_inflammat3.21480772
11MP0001984_abnormal_olfaction2.94028755
12* MP0005636_abnormal_mineral_homeostasis2.73715007
13MP0003638_abnormal_response/metabolism_2.63520452
14MP0003123_paternal_imprinting2.58466842
15MP0003186_abnormal_redox_activity2.56098793
16MP0001485_abnormal_pinna_reflex2.47003896
17MP0004883_abnormal_blood_vessel2.36763552
18MP0001661_extended_life_span2.32605019
19MP0003786_premature_aging2.30106089
20MP0005377_hearing/vestibular/ear_phenot2.25667548
21MP0003878_abnormal_ear_physiology2.25667548
22MP0004084_abnormal_cardiac_muscle2.07306998
23MP0003122_maternal_imprinting2.00987544
24MP0002909_abnormal_adrenal_gland10.4989691
25MP0004085_abnormal_heartbeat1.97575631
26* MP0005319_abnormal_enzyme/_coenzyme1.95971978
27MP0005584_abnormal_enzyme/coenzyme_acti1.94657011
28MP0001756_abnormal_urination1.91945204
29MP0003941_abnormal_skin_development1.87780635
30MP0006276_abnormal_autonomic_nervous1.85333973
31MP0003329_amyloid_beta_deposits1.83407192
32MP0010329_abnormal_lipoprotein_level1.83335833
33* MP0003953_abnormal_hormone_level1.66582290
34MP0009780_abnormal_chondrocyte_physiolo1.65854290
35MP0000538_abnormal_urinary_bladder1.61598839
36MP0004134_abnormal_chest_morphology1.60188186
37MP0000604_amyloidosis1.59852633
38MP0005647_abnormal_sex_gland1.59835238
39MP0005083_abnormal_biliary_tract1.55651456
40MP0003300_gastrointestinal_ulcer1.48550830
41MP0005503_abnormal_tendon_morphology1.42525364
42MP0000647_abnormal_sebaceous_gland1.41040528
43MP0009053_abnormal_anal_canal1.37618482
44MP0003942_abnormal_urinary_system1.37330307
45MP0003191_abnormal_cellular_cholesterol1.33733720
46MP0008438_abnormal_cutaneous_collagen1.31734524
47MP0005164_abnormal_response_to1.27918800
48MP0002160_abnormal_reproductive_system1.24269687
49MP0004036_abnormal_muscle_relaxation1.22225088
50MP0000566_synostosis1.21511952
51MP0000343_altered_response_to1.18778199
52MP0006035_abnormal_mitochondrial_morpho1.18303138
53MP0004019_abnormal_vitamin_homeostasis1.12471005
54MP0003279_aneurysm1.09108959
55MP0003787_abnormal_imprinting1.08699699
56MP0002118_abnormal_lipid_homeostasis1.05129610
57* MP0009643_abnormal_urine_homeostasis1.02208547
58MP0002998_abnormal_bone_remodeling1.01031864
59MP0010630_abnormal_cardiac_muscle1.00780784
60MP0006138_congestive_heart_failure1.00603744
61MP0010368_abnormal_lymphatic_system0.97679834
62MP0003879_abnormal_hair_cell0.96168158
63MP0001879_abnormal_lymphatic_vessel0.95102474
64MP0003690_abnormal_glial_cell0.92727175
65MP0001529_abnormal_vocalization0.92299471
66MP0001915_intracranial_hemorrhage0.90465462
67MP0005595_abnormal_vascular_smooth0.89021833
68MP0002069_abnormal_eating/drinking_beha0.87307104
69MP0003385_abnormal_body_wall0.86972092
70MP0001177_atelectasis0.84843826
71* MP0000631_abnormal_neuroendocrine_gland0.84838930
72MP0003137_abnormal_impulse_conducting0.84530105
73MP0003121_genomic_imprinting0.83471015
74MP0000751_myopathy0.82617236
75MP0002295_abnormal_pulmonary_circulatio0.80459418
76MP0002269_muscular_atrophy0.79638464
77MP0003011_delayed_dark_adaptation0.79033426
78MP0004858_abnormal_nervous_system0.78667480
79MP0004087_abnormal_muscle_fiber0.78441490
80MP0005389_reproductive_system_phenotype0.77450230
81MP0004272_abnormal_basement_membrane0.76478778
82MP0005535_abnormal_body_temperature0.76073318
83MP0004130_abnormal_muscle_cell0.75493920
84* MP0009642_abnormal_blood_homeostasis0.75247946
85MP0004742_abnormal_vestibular_system0.74146465
86MP0003948_abnormal_gas_homeostasis0.72916246
87MP0009250_abnormal_appendicular_skeleto0.72870357
88MP0008872_abnormal_physiological_respon0.70001822
89MP0001440_abnormal_grooming_behavior0.69443697
90* MP0008469_abnormal_protein_level0.69345406
91MP0008057_abnormal_DNA_replication0.69246421
92MP0000609_abnormal_liver_physiology0.68602935
93MP0001544_abnormal_cardiovascular_syste0.66053614
94MP0005385_cardiovascular_system_phenoty0.66053614
95* MP0002078_abnormal_glucose_homeostasis0.65996598
96MP0001501_abnormal_sleep_pattern0.65317185
97MP0002896_abnormal_bone_mineralization0.64523429
98MP0002136_abnormal_kidney_physiology0.64228502
99MP0003566_abnormal_cell_adhesion0.64055877
100MP0000013_abnormal_adipose_tissue0.60461769
101* MP0000266_abnormal_heart_morphology0.59787646
102MP0005330_cardiomyopathy0.59346164
103MP0005187_abnormal_penis_morphology0.58286221
104MP0004145_abnormal_muscle_electrophysio0.57322427
105MP0000678_abnormal_parathyroid_gland0.56213965
106MP0002127_abnormal_cardiovascular_syste0.55958004
107MP0003635_abnormal_synaptic_transmissio0.53727539
108MP0005365_abnormal_bile_salt0.53268627
109MP0003950_abnormal_plasma_membrane0.52378535
110MP0008770_decreased_survivor_rate0.52000870
111MP0000249_abnormal_blood_vessel0.51448447
112MP0002115_abnormal_skeleton_extremities0.51408833
113MP0005387_immune_system_phenotype0.51384185
114MP0001790_abnormal_immune_system0.51384185
115MP0001270_distended_abdomen0.50717986
116MP0004484_altered_response_of0.50594627
117MP0005275_abnormal_skin_tensile0.49924528
118MP0005623_abnormal_meninges_morphology0.49483831
119MP0005379_endocrine/exocrine_gland_phen0.49297822
120MP0003959_abnormal_lean_body0.49136486
121MP0003724_increased_susceptibility_to0.48679541
122MP0005332_abnormal_amino_acid0.48216049
123MP0010769_abnormal_survival0.46863385
124MP0010770_preweaning_lethality0.46736836
125MP0002082_postnatal_lethality0.46736836
126MP0003632_abnormal_nervous_system0.45634778
127* MP0001119_abnormal_female_reproductive0.45522273
128MP0005334_abnormal_fat_pad0.45335966
129MP0001533_abnormal_skeleton_physiology0.43908172
130MP0000003_abnormal_adipose_tissue0.43857962
131MP0010768_mortality/aging0.43274479
132MP0005646_abnormal_pituitary_gland0.42849301
133MP0001929_abnormal_gametogenesis0.42718827
134MP0001299_abnormal_eye_distance/0.42602871
135MP0005058_abnormal_lysosome_morphology0.42493520
136MP0000462_abnormal_digestive_system0.42445610
137MP0003115_abnormal_respiratory_system0.41253861
138MP0005253_abnormal_eye_physiology0.40883555
139MP0002557_abnormal_social/conspecific_i0.40837731
140MP0008874_decreased_physiological_sensi0.40703476
141MP0001958_emphysema0.40313521
142MP0005360_urolithiasis0.39814218
143MP0000470_abnormal_stomach_morphology0.39538065
144MP0001324_abnormal_eye_pigmentation0.39421348
145MP0000750_abnormal_muscle_regeneration0.37543019
146MP0003634_abnormal_glial_cell0.37397407
147MP0000537_abnormal_urethra_morphology0.37034947
148MP0001614_abnormal_blood_vessel0.36167945
149MP0001853_heart_inflammation0.35320204
150MP0001731_abnormal_postnatal_growth0.34939084
151MP0005076_abnormal_cell_differentiation0.33887958
152MP0001963_abnormal_hearing_physiology0.32874394
153MP0005508_abnormal_skeleton_morphology0.32436346
154MP0004264_abnormal_extraembryonic_tissu0.28398798

Predicted human phenotypes

RankGene SetZ-score
1Sex reversal (HP:0012245)8.80634194
2Abnormal sex determination (HP:0012244)8.80634194
3Orthostatic hypotension (HP:0001278)8.78472618
4Complement deficiency (HP:0004431)7.76914957
5Hypokalemic alkalosis (HP:0001949)7.48526507
6* Abnormality of renin-angiotensin system (HP:0000847)6.62936764
7Recurrent gram-negative bacterial infections (HP:0005420)6.31817023
8* Hyperaldosteronism (HP:0000859)6.17219023
9Hyperkalemia (HP:0002153)6.03893339
10Abnormality of complement system (HP:0005339)5.85885524
11Testicular neoplasm (HP:0010788)5.38943819
12* Neonatal onset (HP:0003623)5.23336451
13Episodic fever (HP:0001954)5.03026051
14Azoospermia (HP:0000027)4.89752973
15Congenital sensorineural hearing impairment (HP:0008527)4.74827438
16Neonatal hypoglycemia (HP:0001998)4.70875202
17Multifactorial inheritance (HP:0001426)4.57161578
18Hyponatremia (HP:0002902)4.47570617
19Ventricular fibrillation (HP:0001663)4.43438657
20Abnormal autonomic nervous system physiology (HP:0012332)4.14275442
21Glomerulonephritis (HP:0000099)4.13226384
22Abnormality of sodium homeostasis (HP:0010931)3.89091293
23Bifid scrotum (HP:0000048)3.80135699
24Gonadal dysgenesis (HP:0000133)3.76937798
25Alkalosis (HP:0001948)3.66423600
26* Adrenal overactivity (HP:0002717)3.63652408
27Primary adrenal insufficiency (HP:0008207)3.60994518
28Gynecomastia (HP:0000771)3.59084529
29Mesangial abnormality (HP:0001966)3.57731815
30Abnormal spermatogenesis (HP:0008669)3.44440987
31* Accelerated skeletal maturation (HP:0005616)3.43937026
32Hypotension (HP:0002615)3.43625207
33Neurofibrillary tangles (HP:0002185)3.31886262
34Hypothermia (HP:0002045)3.19858908
35Bilateral sensorineural hearing impairment (HP:0008619)3.14228917
36* Abnormality of potassium homeostasis (HP:0011042)3.11713617
37Syncope (HP:0001279)3.03282611
38Mitral stenosis (HP:0001718)2.99031330
39Wrist flexion contracture (HP:0001239)2.79674485
40Premature ovarian failure (HP:0008209)2.66197791
41Male pseudohermaphroditism (HP:0000037)2.62922364
42Cervical subluxation (HP:0003308)2.58776396
43Nephritis (HP:0000123)2.58376632
44Primary amenorrhea (HP:0000786)2.57306893
45Xanthomatosis (HP:0000991)2.56987451
46Cerebral inclusion bodies (HP:0100314)2.51048813
47Choanal stenosis (HP:0000452)2.45962574
48Hepatoblastoma (HP:0002884)2.44181634
49Abnormal pancreas size (HP:0012094)2.43275744
50Abnormality of carpal bone ossification (HP:0006257)2.42619832
51Hyperpituitarism (HP:0010514)2.41237525
52Hydroxyprolinuria (HP:0003080)2.39796705
53Abnormality of proline metabolism (HP:0010907)2.39796705
54Septate vagina (HP:0001153)2.31857946
55Large earlobe (HP:0009748)2.31339050
56* Decreased circulating renin level (HP:0003351)2.29520186
57Breech presentation (HP:0001623)2.29326706
58Abnormality of the aortic arch (HP:0012303)2.29134530
59Abnormality of the axillary hair (HP:0100134)2.27904722
60Abnormality of secondary sexual hair (HP:0009888)2.27904722
61Abnormality of the fingertips (HP:0001211)2.25916409
62Hypoplastic nipples (HP:0002557)2.22607003
63Secondary amenorrhea (HP:0000869)2.22365225
64Urinary glycosaminoglycan excretion (HP:0003541)2.20922146
65Mucopolysacchariduria (HP:0008155)2.20922146
66Short humerus (HP:0005792)2.20549993
67Hypospadias (HP:0000047)2.17609283
68Lymphangioma (HP:0100764)2.12423258
69Tracheal stenosis (HP:0002777)2.12176548
70Epidermoid cyst (HP:0200040)2.10595782
71Hip contracture (HP:0003273)2.10560264
72Visceral angiomatosis (HP:0100761)2.08378224
73Shawl scrotum (HP:0000049)2.05757528
74Persistence of primary teeth (HP:0006335)2.04541441
75Abnormality of polysaccharide metabolism (HP:0011012)2.04485862
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04485862
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04485862
78Broad alveolar ridges (HP:0000187)2.04135474
79Round ear (HP:0100830)2.01728630
80Abnormal EKG (HP:0003115)2.01351244
81Renal salt wasting (HP:0000127)17.5352360
82Increased circulating renin level (HP:0000848)11.1857482
83Anal stenosis (HP:0002025)1.99365767
84Abnormality of fatty-acid metabolism (HP:0004359)1.99286090
85J-shaped sella turcica (HP:0002680)1.97757265
86Double outlet right ventricle (HP:0001719)1.97302647
87Congenital malformation of the right heart (HP:0011723)1.97302647
88Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96279035
89Aplasia/hypoplasia of the humerus (HP:0006507)1.95688020
90Hemangiomatosis (HP:0007461)1.94339509
91Aplasia of the musculature (HP:0100854)1.92832790
92Neoplasm of the adrenal gland (HP:0100631)1.92601118
93Asymmetric septal hypertrophy (HP:0001670)1.92422586
94Pulmonary fibrosis (HP:0002206)1.90702004
95Patent foramen ovale (HP:0001655)1.90190924
96Hyperglycinuria (HP:0003108)1.89187541
97Abnormal hand bone ossification (HP:0010660)1.87144289
98Facial diplegia (HP:0001349)1.85570887
99Abnormal ossification of hand bones (HP:0005921)1.84819147
100Limited hip movement (HP:0008800)1.83656090
101Hypoalphalipoproteinemia (HP:0003233)1.82051255
102Abnormal tarsal ossification (HP:0008369)1.81839343
103Ureteral duplication (HP:0000073)1.81376145
104Vomiting (HP:0002013)1.79172313
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78629281
106Scrotal hypoplasia (HP:0000046)1.78047285
107Myocardial infarction (HP:0001658)1.76939890
108Metaphyseal cupping (HP:0003021)1.75727130
109Coronal craniosynostosis (HP:0004440)1.73540009
110Dehydration (HP:0001944)1.71916440
111Bicornuate uterus (HP:0000813)1.70429924
112Atrial fibrillation (HP:0005110)1.70063874
113Spinal cord compression (HP:0002176)1.69768077
114Retinal atrophy (HP:0001105)1.68637271
115Abnormality of serine family amino acid metabolism (HP:0010894)1.67445096
116Abnormality of glycine metabolism (HP:0010895)1.67445096
117Short clavicles (HP:0000894)1.67357593
118Ketoacidosis (HP:0001993)1.66666275
119Abnormality of glutamine family amino acid metabolism (HP:0010902)1.64555383
120Sparse lateral eyebrow (HP:0005338)1.64276560
121Knee flexion contracture (HP:0006380)1.62172494
122Microglossia (HP:0000171)1.62095591
123Facial hemangioma (HP:0000329)1.60262053
124Acne (HP:0001061)1.59470637
125Female pseudohermaphroditism (HP:0010458)1.58582569
126Broad metatarsal (HP:0001783)1.57959645
127Increased muscle lipid content (HP:0009058)1.57815206
128Joint stiffness (HP:0001387)1.57731903
129Spinal cord lesions (HP:0100561)1.57482261
130Syringomyelia (HP:0003396)1.57482261
131Skin nodule (HP:0200036)1.57131867
132Large eyes (HP:0001090)1.56340863
133Breast hypoplasia (HP:0003187)1.55674594
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.54496361
135Laryngomalacia (HP:0001601)1.54038394
136Absent hand (HP:0004050)1.54032896
137Ovarian neoplasm (HP:0100615)1.53432807
138Poor suck (HP:0002033)1.52140354
139Hypoglycemic coma (HP:0001325)1.51025962
140Diastasis recti (HP:0001540)1.50673061
141Generalized hypotonia (HP:0001290)1.46319017
142Dicarboxylic aciduria (HP:0003215)1.45352908
143Abnormality of dicarboxylic acid metabolism (HP:0010995)1.45352908
144* Enlarged penis (HP:0000040)1.44880025
145Prolonged QT interval (HP:0001657)1.44719629
146Myoglobinuria (HP:0002913)1.44613966
147Systemic lupus erythematosus (HP:0002725)1.38951185
148Metaphyseal dysplasia (HP:0100255)1.37711360
149Hypokinesia (HP:0002375)1.36304714
150Enlarged kidneys (HP:0000105)1.35251650
151Gastrointestinal dysmotility (HP:0002579)1.33693116
152Protrusio acetabuli (HP:0003179)1.33279655
153Hyperammonemia (HP:0001987)1.32444230
154Striae distensae (HP:0001065)1.30233587
155Ketosis (HP:0001946)1.29904785
156Atrioventricular block (HP:0001678)1.28697996
157Hypercortisolism (HP:0001578)1.26990233
158Ureteral stenosis (HP:0000071)1.22369968
159Bifid tongue (HP:0010297)1.21185981
160Overlapping toe (HP:0001845)1.20469322
161Epiphyseal stippling (HP:0010655)1.20274493
162Pheochromocytoma (HP:0002666)1.20161127
163Increased number of teeth (HP:0011069)1.20118736
164Abnormal hemoglobin (HP:0011902)1.17432507
165Arachnodactyly (HP:0001166)1.17143454
166Polydipsia (HP:0001959)1.16362854
167Abnormal drinking behavior (HP:0030082)1.16362854
168Abnormality of the alveolar ridges (HP:0006477)1.15927145
169Metabolic acidosis (HP:0001942)1.15898621
170Spinal rigidity (HP:0003306)1.14887187
171Advanced eruption of teeth (HP:0006288)1.14778522
172Ureteral obstruction (HP:0006000)1.14590140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.65191696
2ERN14.70826556
3DDR24.34606277
4MELK3.44930450
5JAK12.76029839
6MAP3K52.63535954
7CDK72.59917060
8ICK2.42844471
9BCKDK2.33694264
10EPHB22.30561857
11TAOK32.30026117
12PKN22.26276337
13SIK12.13166651
14TIE12.06312603
15AKT310.3429651
16SIK31.66531672
17TGFBR21.64350903
18RIPK41.57245191
19FGFR41.51463272
20PIM11.43344304
21NTRK31.39078948
22WNK41.37011069
23PTK61.33599312
24STK391.31029447
25AKT21.28782732
26JAK21.24684745
27FER1.23716584
28KDR1.23249997
29PAK41.18583891
30NTRK11.15841989
31PRKAA21.12023786
32TBK11.09870385
33FGFR21.07204926
34CAMK1G1.06979995
35LRRK20.99544296
36MAPK30.96452258
37MAPKAPK50.93156815
38NLK0.88527329
39ILK0.87422672
40SIK20.86620109
41SGK10.85355922
42INSRR0.84656475
43CAMK1D0.82399864
44EPHA30.82196848
45OXSR10.78911004
46NEK90.78381302
47MAPK120.77971052
48SCYL20.75766540
49PINK10.74051139
50PRKCG0.72900374
51STK100.72568174
52RIPK10.69868659
53PRKD10.69509974
54MST1R0.69075418
55PTK20.66377028
56CAMKK10.66034562
57WNK30.65772860
58FGFR10.62204374
59MAP2K10.58680301
60EEF2K0.57456149
61MET0.57287522
62PDPK10.56384583
63CASK0.55228471
64LATS10.54070772
65CSF1R0.53217378
66MTOR0.52221355
67PDGFRA0.51811054
68KSR20.51585144
69MYLK0.51513619
70FRK0.51258280
71PRKACG0.49892931
72PRKACA0.47026199
73SGK20.46997108
74ERBB40.46785651
75MAPK70.46656850
76MAP3K70.45659082
77PDK20.45600949
78TRPM70.44420450
79PAK30.44171583
80MAP3K120.44013028
81MAP3K10.43540263
82PRKCH0.41715629
83PRKCE0.41433435
84SGK30.40676495
85MINK10.40607000
86FLT30.39159183
87CAMKK20.38611623
88PDGFRB0.38279613
89EPHB10.38270185
90SRC0.37541419
91FGFR30.36802681
92IGF1R0.36800475
93CDC42BPA0.34822505
94WNK10.34790853
95SGK2230.34022587
96SGK4940.34022587
97CDK50.33833381
98GRK50.32684487
99PRKACB0.32306041
100MAP3K60.31226591
101PDK10.30622704
102LIMK10.29993758
103MAP2K60.29205984
104PTK2B0.29113729
105PHKG20.29045814
106PHKG10.29045814
107UHMK10.28844983
108CAMK2D0.28827627
109RET0.28166043
110TNIK0.27986560
111MAP3K20.27906844
112MARK20.27564865
113EPHA40.26259455
114CAMK2B0.25783053
115NTRK20.25544450
116PRKCA0.25378323
117MAP3K110.24851324
118RPS6KA30.24604564
119CAMK2A0.24353101
120CSNK1A1L0.23901592
121MAP2K40.23825645
122CAMK10.23538240
123CAMK40.22943014
124ROCK20.22686798
125MAPK10.22527240
126NEK10.21848636
127CAMK2G0.21070744
128FES0.20839673
129MAPK110.20759468
130MAP2K20.20433333
131PRKCD0.20121244
132LATS20.19840719
133TYK20.19423111
134TESK10.18951471
135PRKCZ0.18716001
136YES10.18658975
137PRKG20.18516629
138ABL20.18318730
139PRPF4B0.17772164
140ITK0.15591912
141ADRBK10.13622759
142TTN0.13611383
143RPS6KB10.12756206
144ROCK10.12368200
145HIPK20.11980925
146MAPK90.10863583
147KIT0.09658204

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007508.14385669
2Aldosterone synthesis and secretion_Homo sapiens_hsa049257.34858804
3* Steroid hormone biosynthesis_Homo sapiens_hsa001406.62237969
4Ovarian steroidogenesis_Homo sapiens_hsa049135.92609851
5Tyrosine metabolism_Homo sapiens_hsa003504.37234400
6Fatty acid metabolism_Homo sapiens_hsa012123.05845124
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.98413574
8Fatty acid degradation_Homo sapiens_hsa000712.68223221
9Vitamin digestion and absorption_Homo sapiens_hsa049772.18276452
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93943821
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88775929
12Fatty acid biosynthesis_Homo sapiens_hsa000611.85657407
13Fat digestion and absorption_Homo sapiens_hsa049751.71600475
14Propanoate metabolism_Homo sapiens_hsa006401.66857035
15PPAR signaling pathway_Homo sapiens_hsa033201.58959022
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54029236
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49025679
18Prolactin signaling pathway_Homo sapiens_hsa049171.46856260
19Bile secretion_Homo sapiens_hsa049761.39980791
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28032560
21Steroid biosynthesis_Homo sapiens_hsa001001.27266429
22Pyruvate metabolism_Homo sapiens_hsa006201.22054515
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21483840
24Fatty acid elongation_Homo sapiens_hsa000621.21242923
25ABC transporters_Homo sapiens_hsa020101.20126966
26Selenocompound metabolism_Homo sapiens_hsa004501.14569245
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10142664
28Carbon metabolism_Homo sapiens_hsa012001.08467921
29beta-Alanine metabolism_Homo sapiens_hsa004101.01072009
30Renin secretion_Homo sapiens_hsa049240.97358946
31Butanoate metabolism_Homo sapiens_hsa006500.97267488
32Phospholipase D signaling pathway_Homo sapiens_hsa040720.74786642
33Systemic lupus erythematosus_Homo sapiens_hsa053220.73448380
34Tryptophan metabolism_Homo sapiens_hsa003800.71353702
35cAMP signaling pathway_Homo sapiens_hsa040240.68714712
36Peroxisome_Homo sapiens_hsa041460.68498709
37Nitrogen metabolism_Homo sapiens_hsa009100.65270936
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59643890
39Circadian entrainment_Homo sapiens_hsa047130.57964393
40Pentose phosphate pathway_Homo sapiens_hsa000300.56359766
41Retinol metabolism_Homo sapiens_hsa008300.56207605
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55510082
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53350421
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.53007064
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52986872
46Phagosome_Homo sapiens_hsa041450.50032355
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49107299
48Other glycan degradation_Homo sapiens_hsa005110.48793362
49Gap junction_Homo sapiens_hsa045400.48014549
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46805777
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46573587
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45074074
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44876351
54Lysosome_Homo sapiens_hsa041420.43327136
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42526644
56Protein digestion and absorption_Homo sapiens_hsa049740.41761487
57Choline metabolism in cancer_Homo sapiens_hsa052310.41643554
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.41471377
59Phenylalanine metabolism_Homo sapiens_hsa003600.41390884
60Morphine addiction_Homo sapiens_hsa050320.41301965
61Cocaine addiction_Homo sapiens_hsa050300.40536747
62Amoebiasis_Homo sapiens_hsa051460.40029125
63Dopaminergic synapse_Homo sapiens_hsa047280.39439597
64Sulfur metabolism_Homo sapiens_hsa009200.37758865
65Oxidative phosphorylation_Homo sapiens_hsa001900.36812333
66Lysine degradation_Homo sapiens_hsa003100.36307518
67Histidine metabolism_Homo sapiens_hsa003400.36248194
68Chemical carcinogenesis_Homo sapiens_hsa052040.36110237
69Small cell lung cancer_Homo sapiens_hsa052220.35626650
70Parkinsons disease_Homo sapiens_hsa050120.35053702
71Melanoma_Homo sapiens_hsa052180.33570915
72Staphylococcus aureus infection_Homo sapiens_hsa051500.32736408
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32402992
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31742852
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31659360
76Synaptic vesicle cycle_Homo sapiens_hsa047210.30659514
77Calcium signaling pathway_Homo sapiens_hsa040200.30415931
78Prion diseases_Homo sapiens_hsa050200.30015418
79Vibrio cholerae infection_Homo sapiens_hsa051100.29920705
80Alzheimers disease_Homo sapiens_hsa050100.29581605
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29285467
82Dorso-ventral axis formation_Homo sapiens_hsa043200.28915023
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.28877188
84Amphetamine addiction_Homo sapiens_hsa050310.27107868
85Cardiac muscle contraction_Homo sapiens_hsa042600.27104518
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26878398
87Glycerolipid metabolism_Homo sapiens_hsa005610.26867790
88GnRH signaling pathway_Homo sapiens_hsa049120.26797454
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26366770
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26190378
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26011433
92Complement and coagulation cascades_Homo sapiens_hsa046100.25728911
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.25668284
94Pancreatic secretion_Homo sapiens_hsa049720.25553079
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24720676
96Sphingolipid metabolism_Homo sapiens_hsa006000.24598865
97Hepatitis C_Homo sapiens_hsa051600.24062556
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23870361
99Prostate cancer_Homo sapiens_hsa052150.23600923
100GABAergic synapse_Homo sapiens_hsa047270.23453260
101Mineral absorption_Homo sapiens_hsa049780.23442478
102Insulin secretion_Homo sapiens_hsa049110.23323769
103Toxoplasmosis_Homo sapiens_hsa051450.22334857
104* Metabolic pathways_Homo sapiens_hsa011000.22187035
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20947156
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20675872
107Insulin resistance_Homo sapiens_hsa049310.20422831
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20317736
109Oxytocin signaling pathway_Homo sapiens_hsa049210.19748558
110Collecting duct acid secretion_Homo sapiens_hsa049660.19023082
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18819398
112Dilated cardiomyopathy_Homo sapiens_hsa054140.18558210
113Circadian rhythm_Homo sapiens_hsa047100.17847327
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.17740922
115Serotonergic synapse_Homo sapiens_hsa047260.16691418
116mTOR signaling pathway_Homo sapiens_hsa041500.15800926
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15625879
118Biosynthesis of amino acids_Homo sapiens_hsa012300.15070046
119Glutathione metabolism_Homo sapiens_hsa004800.14650028
120Focal adhesion_Homo sapiens_hsa045100.14230816
121Estrogen signaling pathway_Homo sapiens_hsa049150.13660213
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13564999
123Long-term depression_Homo sapiens_hsa047300.13093161
124Renin-angiotensin system_Homo sapiens_hsa046140.12160780
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12032410
126Salivary secretion_Homo sapiens_hsa049700.10923540
127Linoleic acid metabolism_Homo sapiens_hsa005910.10512663
128Pertussis_Homo sapiens_hsa051330.10355003
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09597386
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.08829602
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.08215923
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08157320
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.07996908
134Thyroid hormone synthesis_Homo sapiens_hsa049180.07809468
135Gastric acid secretion_Homo sapiens_hsa049710.07093155
136Cholinergic synapse_Homo sapiens_hsa047250.06994468
137TNF signaling pathway_Homo sapiens_hsa046680.06790657
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06660803
139MicroRNAs in cancer_Homo sapiens_hsa052060.05392952
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.04982146
141ECM-receptor interaction_Homo sapiens_hsa045120.04334401
142Rap1 signaling pathway_Homo sapiens_hsa040150.04138136

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