CYLC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.82124057
2spermatid development (GO:0007286)9.58479043
3motile cilium assembly (GO:0044458)9.32107044
4regulation of cilium movement (GO:0003352)8.71026505
5cilium movement (GO:0003341)8.62679447
6single fertilization (GO:0007338)8.03486600
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.89627945
8piRNA metabolic process (GO:0034587)7.88776345
9male meiosis (GO:0007140)7.49689482
10sperm capacitation (GO:0048240)7.26906025
11synaptonemal complex organization (GO:0070193)7.08724734
12synaptonemal complex assembly (GO:0007130)6.88395079
13fertilization (GO:0009566)6.72777790
14* spermatogenesis (GO:0007283)6.48870861
15* male gamete generation (GO:0048232)6.47003185
16negative regulation of inclusion body assembly (GO:0090084)6.43265900
17microtubule depolymerization (GO:0007019)6.38185311
18organic cation transport (GO:0015695)6.20623503
19* gamete generation (GO:0007276)5.96054089
20ventricular system development (GO:0021591)5.63207367
21cellular process involved in reproduction in multicellular organism (GO:0022412)5.44850863
22germ cell development (GO:0007281)5.39789878
23calcium ion-dependent exocytosis (GO:0017156)5.35862114
24male meiosis I (GO:0007141)5.26616809
25regulation of inclusion body assembly (GO:0090083)5.24879464
26DNA methylation involved in gamete generation (GO:0043046)5.19683816
27regulation of microtubule-based movement (GO:0060632)5.16382059
28glycerol ether metabolic process (GO:0006662)4.98808206
29cell recognition (GO:0008037)4.95848464
30chromosome organization involved in meiosis (GO:0070192)4.75478509
31* multicellular organismal reproductive process (GO:0048609)4.70965586
32ether metabolic process (GO:0018904)4.60468755
33seminiferous tubule development (GO:0072520)4.47684878
34meiotic nuclear division (GO:0007126)4.29138076
35microtubule severing (GO:0051013)4.23722614
36left/right pattern formation (GO:0060972)4.18261886
37meiosis I (GO:0007127)4.14171489
38chromosome condensation (GO:0030261)4.00656017
39DNA packaging (GO:0006323)3.98670426
40genitalia morphogenesis (GO:0035112)3.84451658
41* multicellular organismal development (GO:0007275)3.82990756
42meiotic cell cycle (GO:0051321)3.79428007
43spermatid nucleus differentiation (GO:0007289)3.77882709
44chaperone-mediated protein complex assembly (GO:0051131)3.76384235
45monoubiquitinated protein deubiquitination (GO:0035520)3.71381937
46microtubule polymerization or depolymerization (GO:0031109)3.37175361
47protein localization to cilium (GO:0061512)3.32773613
48protein polyglutamylation (GO:0018095)3.31980295
49lactate metabolic process (GO:0006089)3.25327864
50nucleoside diphosphate phosphorylation (GO:0006165)3.24231671
51GTP biosynthetic process (GO:0006183)3.23437747
52glycolytic process (GO:0006096)3.20310289
53sexual reproduction (GO:0019953)3.19583497
54single strand break repair (GO:0000012)3.19195634
55protein K11-linked deubiquitination (GO:0035871)3.15760257
56protein refolding (GO:0042026)3.13117621
57polyol catabolic process (GO:0046174)3.10639393
58alditol metabolic process (GO:0019400)3.10205916
59regulation of spindle checkpoint (GO:0090231)3.07236865
60amino-acid betaine transport (GO:0015838)3.03318242
61carnitine transport (GO:0015879)3.03318242
62sequestering of actin monomers (GO:0042989)3.02788420
63negative regulation of organelle assembly (GO:1902116)2.99234901
64microtubule-based movement (GO:0007018)2.96191337
65synapsis (GO:0007129)2.90452948
66cilium organization (GO:0044782)2.89376212
67carnitine transmembrane transport (GO:1902603)2.88117445
68UTP biosynthetic process (GO:0006228)2.87092940
69axoneme assembly (GO:0035082)2.86138775
70meiotic cell cycle process (GO:1903046)2.77675916
71centriole assembly (GO:0098534)2.77302887
72cilium assembly (GO:0042384)2.77239635
73cellular component assembly involved in morphogenesis (GO:0010927)2.75265981
74interferon-gamma secretion (GO:0072643)2.74561320
75nucleus organization (GO:0006997)2.70550041
76intraciliary transport (GO:0042073)2.64956729
77mitotic sister chromatid cohesion (GO:0007064)2.64947241
78gene silencing by RNA (GO:0031047)2.62438822
79glycerol metabolic process (GO:0006071)2.62200838
80UTP metabolic process (GO:0046051)2.61318306
81cilium morphogenesis (GO:0060271)2.58441918
82regulation of protein kinase C signaling (GO:0090036)2.57654937
83RNA destabilization (GO:0050779)2.46386182
84calcium ion import (GO:0070509)2.44315323
85nuclear pore complex assembly (GO:0051292)2.43901932
86regulation of protein kinase A signaling (GO:0010738)2.42355175
87fusion of sperm to egg plasma membrane (GO:0007342)14.8090787
88sperm motility (GO:0030317)14.2568058
89multicellular organism reproduction (GO:0032504)11.7142136
90acrosome reaction (GO:0007340)11.7087963
91acrosome assembly (GO:0001675)11.6012418
92sperm-egg recognition (GO:0035036)11.3998662
93cilium or flagellum-dependent cell motility (GO:0001539)11.3125944
94plasma membrane fusion (GO:0045026)11.2910171
95cell wall macromolecule metabolic process (GO:0044036)10.9954006
96cell wall macromolecule catabolic process (GO:0016998)10.9954006
97axonemal dynein complex assembly (GO:0070286)10.5989064
98binding of sperm to zona pellucida (GO:0007339)10.3164224
99cell-cell recognition (GO:0009988)10.1695055
100epithelial cilium movement (GO:0003351)10.1464129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.43847189
2EZH2_22144423_ChIP-Seq_EOC_Human4.72221676
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.18959639
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.35737831
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91321906
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.40359611
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.27856910
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24270894
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14959514
10VDR_22108803_ChIP-Seq_LS180_Human2.12072199
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.11844393
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07410515
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04561775
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92687716
15ZNF274_21170338_ChIP-Seq_K562_Hela1.90025418
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.85470589
17PCGF2_27294783_Chip-Seq_NPCs_Mouse1.84618703
18KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.81163424
19STAT1_17558387_ChIP-Seq_HELA_Human1.75152630
20RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.70711405
21NFE2_27457419_Chip-Seq_LIVER_Mouse1.70336790
22TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68966869
23TAL1_26923725_Chip-Seq_HPCs_Mouse1.68530932
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65114330
25CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64427040
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62425400
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.57103352
28KDM2B_26808549_Chip-Seq_REH_Human1.55481667
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.54493823
30GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53649866
31WDR5_24793694_ChIP-Seq_LNCAP_Human1.52256127
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49777159
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46820206
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46820206
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.44634624
36RNF2_27304074_Chip-Seq_NSC_Mouse1.40549378
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.39606378
38REST_21632747_ChIP-Seq_MESCs_Mouse1.39593398
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.39383546
40CBP_20019798_ChIP-Seq_JUKART_Human1.38625718
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38625718
42FUS_26573619_Chip-Seq_HEK293_Human1.37776042
43FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36710842
44CRX_20693478_ChIP-Seq_RETINA_Mouse1.34436427
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.33304771
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31631463
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.29374340
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28220039
49LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28121965
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.27413963
51CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27274200
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26273199
53TAF15_26573619_Chip-Seq_HEK293_Human1.26025645
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25658057
55P53_22387025_ChIP-Seq_ESCs_Mouse1.25334686
56OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22666354
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.22014413
58OCT4_18555785_Chip-Seq_ESCs_Mouse1.21310573
59GF1_26923725_Chip-Seq_HPCs_Mouse1.20365693
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20309905
61SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19044001
62* GATA3_21867929_ChIP-Seq_TH1_Mouse1.16670245
63CMYC_18555785_Chip-Seq_ESCs_Mouse1.16203349
64P53_21459846_ChIP-Seq_SAOS-2_Human1.14787815
65P300_18555785_Chip-Seq_ESCs_Mouse1.14208987
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12892962
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12503519
68KLF4_18555785_Chip-Seq_ESCs_Mouse1.10654770
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10208492
70RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08953156
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08504651
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06869208
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06670366
74FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05735604
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04549507
76ERG_20517297_ChIP-Seq_VCAP_Human1.04360020
77CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03522262
78PU1_27457419_Chip-Seq_LIVER_Mouse1.01974131
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01783087
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.01632526
81SOX9_26525672_Chip-Seq_HEART_Mouse1.01409452
82CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00750374
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.00597243
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.00483103
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99677050
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98575238
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97838636
88CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96770249
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96215511
90NMYC_18555785_Chip-Seq_ESCs_Mouse0.94061210
91MYC_27129775_Chip-Seq_CORNEA_Mouse0.92915309
92CTCF_18555785_Chip-Seq_ESCs_Mouse0.91629328
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91209257
94RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91060795
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90382292
96HTT_18923047_ChIP-ChIP_STHdh_Human0.89936506
97SPI1_26923725_Chip-Seq_HPCs_Mouse0.89880692
98RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89870651
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89717873
100NFYB_21822215_ChIP-Seq_K562_Human0.89408342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.11574688
2MP0001929_abnormal_gametogenesis5.42639862
3MP0008877_abnormal_DNA_methylation4.28574814
4MP0002210_abnormal_sex_determination3.39650976
5MP0002161_abnormal_fertility/fecundity3.31110471
6MP0005670_abnormal_white_adipose2.88540243
7MP0001145_abnormal_male_reproductive2.81971264
8MP0000653_abnormal_sex_gland2.43941363
9MP0002653_abnormal_ependyma_morphology2.21217990
10MP0005410_abnormal_fertilization16.3947388
11MP0005623_abnormal_meninges_morphology1.57051265
12MP0002160_abnormal_reproductive_system1.51595642
13MP0005647_abnormal_sex_gland1.33704320
14MP0002282_abnormal_trachea_morphology1.33460054
15MP0003646_muscle_fatigue1.24669730
16MP0001765_abnormal_ion_homeostasis1.22836654
17MP0008995_early_reproductive_senescence1.16124696
18MP0004233_abnormal_muscle_weight1.08658267
19MP0009046_muscle_twitch0.96873190
20MP0005389_reproductive_system_phenotype0.83003117
21MP0003950_abnormal_plasma_membrane0.80278212
22MP0001984_abnormal_olfaction0.75360981
23MP0001727_abnormal_embryo_implantation0.74564435
24MP0003011_delayed_dark_adaptation0.72276795
25MP0005377_hearing/vestibular/ear_phenot0.70889488
26MP0003878_abnormal_ear_physiology0.70889488
27MP0005257_abnormal_intraocular_pressure0.69462665
28MP0004742_abnormal_vestibular_system0.66868372
29MP0004036_abnormal_muscle_relaxation0.63643511
30MP0003115_abnormal_respiratory_system0.63162953
31MP0001764_abnormal_homeostasis0.61738444
32MP0001502_abnormal_circadian_rhythm0.61129874
33MP0008058_abnormal_DNA_repair0.59206892
34MP0001348_abnormal_lacrimal_gland0.58832395
35MP0005636_abnormal_mineral_homeostasis0.57591815
36MP0005666_abnormal_adipose_tissue0.57290846
37MP0002928_abnormal_bile_duct0.56292319
38MP0002234_abnormal_pharynx_morphology0.53979752
39MP0001440_abnormal_grooming_behavior0.53949795
40MP0002139_abnormal_hepatobiliary_system0.53052257
41MP0010094_abnormal_chromosome_stability0.52938371
42MP0000569_abnormal_digit_pigmentation0.51532132
43MP0003699_abnormal_female_reproductive0.49505344
44MP0005253_abnormal_eye_physiology0.48329952
45MP0009278_abnormal_bone_marrow0.46265412
46MP0008057_abnormal_DNA_replication0.44770061
47MP0002735_abnormal_chemical_nociception0.44647185
48MP0002736_abnormal_nociception_after0.44508871
49MP0000920_abnormal_myelination0.42886770
50MP0005360_urolithiasis0.42550824
51MP0001661_extended_life_span0.40304622
52MP0001545_abnormal_hematopoietic_system0.39233294
53MP0005397_hematopoietic_system_phenotyp0.39233294
54MP0005551_abnormal_eye_electrophysiolog0.38630803
55MP0004019_abnormal_vitamin_homeostasis0.38551973
56MP0001324_abnormal_eye_pigmentation0.38122293
57MP0003786_premature_aging0.36257920
58MP0001293_anophthalmia0.33416816
59MP0002269_muscular_atrophy0.32690211
60MP0005391_vision/eye_phenotype0.32254958
61MP0002876_abnormal_thyroid_physiology0.30626692
62MP0005423_abnormal_somatic_nervous0.29857718
63MP0001968_abnormal_touch/_nociception0.29319034
64MP0002163_abnormal_gland_morphology0.28577309
65MP0003252_abnormal_bile_duct0.27076116
66MP0001119_abnormal_female_reproductive0.26881331
67MP0004270_analgesia0.26616564
68MP0003329_amyloid_beta_deposits0.25922528
69MP0009115_abnormal_fat_cell0.25278049
70MP0000358_abnormal_cell_content/0.25208586
71MP0004134_abnormal_chest_morphology0.24536662
72MP0003879_abnormal_hair_cell0.23496925
73MP0002152_abnormal_brain_morphology0.22260932
74MP0002102_abnormal_ear_morphology0.22248714
75MP0003633_abnormal_nervous_system0.21240988
76MP0002572_abnormal_emotion/affect_behav0.21029764
77MP0005535_abnormal_body_temperature0.20823261
78MP0006036_abnormal_mitochondrial_physio0.20064082
79MP0005365_abnormal_bile_salt0.19372465
80MP0003861_abnormal_nervous_system0.18866117
81MP0005646_abnormal_pituitary_gland0.18427758
82MP0000427_abnormal_hair_cycle0.17887641
83MP0003942_abnormal_urinary_system0.17837198
84MP0000751_myopathy0.17792410
85MP0002796_impaired_skin_barrier0.17766771
86MP0002272_abnormal_nervous_system0.17288324
87MP0005379_endocrine/exocrine_gland_phen0.17035151
88MP0002169_no_abnormal_phenotype0.17022057
89MP0002873_normal_phenotype0.16821924
90MP0002067_abnormal_sensory_capabilities0.16786258
91MP0002971_abnormal_brown_adipose0.16628701
92MP0008569_lethality_at_weaning0.16574577
93MP0002295_abnormal_pulmonary_circulatio0.16227451
94MP0004043_abnormal_pH_regulation0.15551933
95MP0000383_abnormal_hair_follicle0.15486787
96MP0000534_abnormal_ureter_morphology0.14886861
97MP0003631_nervous_system_phenotype0.14559667
98MP0002229_neurodegeneration0.14528101
99MP0000462_abnormal_digestive_system0.13959241
100MP0004811_abnormal_neuron_physiology0.13846655

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.90921960
2Abnormal respiratory motile cilium morphology (HP:0005938)9.37349304
3Abnormal respiratory epithelium morphology (HP:0012253)9.37349304
4Abnormal ciliary motility (HP:0012262)8.55509674
5Rhinitis (HP:0012384)7.26981347
6Chronic bronchitis (HP:0004469)6.95195483
7Infertility (HP:0000789)6.95081540
8Nasal polyposis (HP:0100582)5.96411340
9Abnormality of the nasal mucosa (HP:0000433)4.89447963
10Male infertility (HP:0003251)4.67041961
11Bronchiectasis (HP:0002110)4.50518532
12Bronchitis (HP:0012387)4.35795545
13Nephronophthisis (HP:0000090)4.04855721
14Recurrent sinusitis (HP:0011108)3.93431477
15Abnormal spermatogenesis (HP:0008669)3.79518573
16Tubulointerstitial nephritis (HP:0001970)3.29893502
17Recurrent otitis media (HP:0000403)3.26887463
18Abnormality of the renal medulla (HP:0100957)3.09634866
19Recurrent bronchitis (HP:0002837)2.62862253
20Tubulointerstitial abnormality (HP:0001969)2.59194029
21Tubular atrophy (HP:0000092)2.49837826
22Azoospermia (HP:0000027)2.48276050
23Gonadotropin excess (HP:0000837)2.40670055
24Abnormality of midbrain morphology (HP:0002418)2.28787805
25Molar tooth sign on MRI (HP:0002419)2.28787805
26Impulsivity (HP:0100710)2.25738925
27Dyschromatopsia (HP:0007641)2.19211754
28Abnormal gallbladder physiology (HP:0012438)2.15822874
29Cholecystitis (HP:0001082)2.15822874
30Dynein arm defect of respiratory motile cilia (HP:0012255)14.1560648
31Absent/shortened dynein arms (HP:0200106)14.1560648
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0093871
33Tubulointerstitial fibrosis (HP:0005576)1.90335994
34Bell-shaped thorax (HP:0001591)1.90061878
35Postaxial foot polydactyly (HP:0001830)1.89052297
36Medial flaring of the eyebrow (HP:0010747)1.86830475
37Decreased central vision (HP:0007663)1.85759306
38Stage 5 chronic kidney disease (HP:0003774)1.85103474
39J-shaped sella turcica (HP:0002680)1.84782656
40Spastic tetraparesis (HP:0001285)1.81370036
41Hemorrhage of the eye (HP:0011885)1.69587062
42Microglossia (HP:0000171)1.69524262
43Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68301101
44Congenital hepatic fibrosis (HP:0002612)1.68241304
45Abnormality of the renal cortex (HP:0011035)1.65738006
46Choroideremia (HP:0001139)1.64563133
47Fibular hypoplasia (HP:0003038)1.62839189
48Abnormal drinking behavior (HP:0030082)1.62587282
49Polydipsia (HP:0001959)1.62587282
50Abnormality of the lower motor neuron (HP:0002366)1.59328302
51Hemiparesis (HP:0001269)1.57736744
52Asymmetric septal hypertrophy (HP:0001670)1.55068020
53Facial cleft (HP:0002006)1.54582082
54Heterotopia (HP:0002282)1.53876203
55Short ribs (HP:0000773)1.53051890
56Abnormality of renal excretion (HP:0011036)1.51032655
57Abnormal biliary tract physiology (HP:0012439)1.50977603
58Bile duct proliferation (HP:0001408)1.50977603
59Impaired proprioception (HP:0010831)1.48762717
60Absent frontal sinuses (HP:0002688)1.46421583
61Amyotrophic lateral sclerosis (HP:0007354)1.45018064
62Abnormality of permanent molar morphology (HP:0011071)1.44606808
63Abnormality of the dental root (HP:0006486)1.44606808
64Taurodontia (HP:0000679)1.44606808
65Oculomotor apraxia (HP:0000657)1.43073390
66Deformed sella turcica (HP:0002681)1.42149568
67Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.41586990
68Abnormality of molar (HP:0011077)1.40020084
69Abnormality of molar morphology (HP:0011070)1.40020084
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.39303548
71Absent epiphyses (HP:0010577)1.39303548
72Short thorax (HP:0010306)1.37793067
73Median cleft lip (HP:0000161)1.32743126
74Postaxial hand polydactyly (HP:0001162)1.32195286
75Neurofibrillary tangles (HP:0002185)1.31930415
76Abnormality of dentin (HP:0010299)1.31403646
77Abnormality of the dental pulp (HP:0006479)1.31335449
78Renal dysplasia (HP:0000110)1.27918739
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.27095823
80Nephropathy (HP:0000112)1.25959169
81Vascular calcification (HP:0004934)1.25901063
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.24150943
83Rhizomelia (HP:0008905)1.21146596
84Abnormal urine output (HP:0012590)1.20181694
85Decreased motor nerve conduction velocity (HP:0003431)1.17962794
86Chronic sinusitis (HP:0011109)1.16933609
87Constricted visual fields (HP:0001133)1.15791665
88Cardiovascular calcification (HP:0011915)1.14317730
89Bundle branch block (HP:0011710)1.12486162
90Abnormality of the sella turcica (HP:0002679)1.11278218
91Supernumerary spleens (HP:0009799)1.11187270
92Broad distal phalanx of finger (HP:0009836)1.10201507
93Attenuation of retinal blood vessels (HP:0007843)1.10008219
94Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.08315967
95Cerebral inclusion bodies (HP:0100314)1.08148280
96Cystic liver disease (HP:0006706)1.07893246
97Peripheral hypomyelination (HP:0007182)1.06493701
98Delayed gross motor development (HP:0002194)1.04794084
99Aplasia/Hypoplasia of the lens (HP:0008063)1.04031888
100Pachygyria (HP:0001302)1.01003439

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.40630470
2PDK48.40630470
3PDK25.42025735
4TESK15.32750105
5PRKD34.95871256
6ICK4.11293341
7PNCK2.46662981
8STK392.37178240
9PTK2B2.37152451
10WNK42.36014137
11NEK21.45651890
12DYRK1B1.38953842
13STK381.34447585
14PDK11.17746161
15TYRO31.13709455
16WNK11.03966696
17TESK20.92649378
18MAPK150.90985701
19DYRK30.85805212
20CAMK1G0.84332946
21STK30.84040997
22MAP2K60.71799659
23PINK10.67040006
24PDPK10.62411210
25TTK0.60777439
26PASK0.58608216
27EEF2K0.51434916
28IRAK10.49951228
29RIPK40.45938679
30CHEK20.43898355
31PAK20.42601404
32BMPR1B0.40650020
33NTRK20.38772820
34CHEK10.37275595
35PAK10.37135262
36ATR0.36406648
37DDR20.35328793
38LMTK20.35242621
39ATM0.29923226
40MAP3K40.29626079
41CCNB10.29270824
42STK110.28559487
43MUSK0.28348775
44PRKCG0.25354491
45NEK60.23345804
46EPHB10.23256650
47MET0.22913179
48CAMKK10.22507605
49PKN10.22205758
50MAPKAPK50.21813963
51MTOR0.21041041
52MARK30.20690437
53PRKCQ0.19046830
54CSNK1D0.18970348
55PRKAA10.17554882
56LATS10.16137939
57BCR0.15808199
58MARK20.15579143
59FER0.14681052
60WNK30.13418465
61MAP3K100.12969677
62CAMK2A0.11100873
63CLK10.10813736
64MAP3K50.10570151
65CDK150.09878294
66STK100.09412374
67TBK10.09119751
68STK38L0.08542666
69CSK0.08516673
70FGR0.08326026
71MST1R0.08122289
72WEE10.07494451
73OXSR10.07341730
74CDK180.07220148
75PRKG10.07001911
76PRKACG0.06907793
77PLK10.06852109
78GSK3B0.06833200
79CDK120.06048731
80RPS6KB10.05988014
81PRKCD0.05666705
82IRAK20.05621371
83EPHA40.05452187
84CDK11A0.05278210
85PRKCZ0.04489172
86PRKCB0.04351114
87SRC0.04239426
88YES10.04060769
89TNIK0.03926935
90CSF1R0.03726939
91CDK140.03580182
92PRKDC0.03433638
93DAPK20.03372113
94CDC70.03184624
95MAP2K70.03102658
96PRKACA0.03092352
97PLK40.03059406
98PAK60.02863453
99CDK10.02289390
100PRKACB0.02245056

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.52312367
2Fatty acid biosynthesis_Homo sapiens_hsa000614.38968778
3Vitamin B6 metabolism_Homo sapiens_hsa007504.02578148
4Pyruvate metabolism_Homo sapiens_hsa006203.64041016
5Propanoate metabolism_Homo sapiens_hsa006403.51363357
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86229372
7Linoleic acid metabolism_Homo sapiens_hsa005912.78718488
8Glucagon signaling pathway_Homo sapiens_hsa049222.65757178
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.41893681
10Glycerolipid metabolism_Homo sapiens_hsa005612.20392222
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14524423
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.06318980
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02149168
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.00719528
15Selenocompound metabolism_Homo sapiens_hsa004501.99024932
16PPAR signaling pathway_Homo sapiens_hsa033201.93415717
17Dorso-ventral axis formation_Homo sapiens_hsa043201.83687885
18Basal transcription factors_Homo sapiens_hsa030221.79884963
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.63619764
20Collecting duct acid secretion_Homo sapiens_hsa049661.63468561
21Oocyte meiosis_Homo sapiens_hsa041141.54904888
22Ether lipid metabolism_Homo sapiens_hsa005651.50252036
23Mineral absorption_Homo sapiens_hsa049781.49149412
24Fatty acid metabolism_Homo sapiens_hsa012121.48541675
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.47670008
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.43440219
27Pentose phosphate pathway_Homo sapiens_hsa000301.41903306
28Fatty acid degradation_Homo sapiens_hsa000711.40339382
29Amphetamine addiction_Homo sapiens_hsa050311.39345583
30Fanconi anemia pathway_Homo sapiens_hsa034601.37744523
31Cardiac muscle contraction_Homo sapiens_hsa042601.32490602
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28007887
33Fructose and mannose metabolism_Homo sapiens_hsa000511.26493149
34Renin secretion_Homo sapiens_hsa049241.22833966
35Carbon metabolism_Homo sapiens_hsa012001.15164117
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14020106
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10689817
38Fat digestion and absorption_Homo sapiens_hsa049751.04448840
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00831777
40Huntingtons disease_Homo sapiens_hsa050160.95574492
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90885493
42Biosynthesis of amino acids_Homo sapiens_hsa012300.90323330
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89469215
44mRNA surveillance pathway_Homo sapiens_hsa030150.88745746
45Antigen processing and presentation_Homo sapiens_hsa046120.87254592
46Chemical carcinogenesis_Homo sapiens_hsa052040.82543149
47Bile secretion_Homo sapiens_hsa049760.81158735
48Insulin secretion_Homo sapiens_hsa049110.80036310
49Purine metabolism_Homo sapiens_hsa002300.75591687
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71229438
51Inositol phosphate metabolism_Homo sapiens_hsa005620.70966838
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.70497552
53Synaptic vesicle cycle_Homo sapiens_hsa047210.69150894
54Calcium signaling pathway_Homo sapiens_hsa040200.68373155
55Salivary secretion_Homo sapiens_hsa049700.67888178
56ABC transporters_Homo sapiens_hsa020100.65911158
57RNA transport_Homo sapiens_hsa030130.63164881
58Hedgehog signaling pathway_Homo sapiens_hsa043400.62799922
59Arachidonic acid metabolism_Homo sapiens_hsa005900.62652245
60Protein digestion and absorption_Homo sapiens_hsa049740.62364663
61Thyroid hormone synthesis_Homo sapiens_hsa049180.62277137
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60582709
63Glutathione metabolism_Homo sapiens_hsa004800.60501287
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58644733
65Estrogen signaling pathway_Homo sapiens_hsa049150.56269175
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52968144
67Long-term potentiation_Homo sapiens_hsa047200.52027275
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.51875011
69Pancreatic secretion_Homo sapiens_hsa049720.48445742
70Taste transduction_Homo sapiens_hsa047420.47758289
71Metabolic pathways_Homo sapiens_hsa011000.42876928
72Sphingolipid metabolism_Homo sapiens_hsa006000.42223526
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41736540
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41334078
75Gastric acid secretion_Homo sapiens_hsa049710.40325697
76Circadian entrainment_Homo sapiens_hsa047130.40023227
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36376907
78Legionellosis_Homo sapiens_hsa051340.34128137
79Endocytosis_Homo sapiens_hsa041440.33844095
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.31735211
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30918876
82Phagosome_Homo sapiens_hsa041450.30720973
83cAMP signaling pathway_Homo sapiens_hsa040240.30598816
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29839550
85Retinol metabolism_Homo sapiens_hsa008300.29280914
86AMPK signaling pathway_Homo sapiens_hsa041520.26934936
87Fatty acid elongation_Homo sapiens_hsa000620.26299371
88Glutamatergic synapse_Homo sapiens_hsa047240.26179187
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.24910387
90VEGF signaling pathway_Homo sapiens_hsa043700.24333741
91Renin-angiotensin system_Homo sapiens_hsa046140.22298828
92Nicotine addiction_Homo sapiens_hsa050330.21750866
93Complement and coagulation cascades_Homo sapiens_hsa046100.20235091
94Vibrio cholerae infection_Homo sapiens_hsa051100.19365564
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14459259
96Ovarian steroidogenesis_Homo sapiens_hsa049130.14186841
97Morphine addiction_Homo sapiens_hsa050320.12528017
98Cocaine addiction_Homo sapiens_hsa050300.12068336
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10896446
100Type II diabetes mellitus_Homo sapiens_hsa049300.07945314

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