CYCSP34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.74718421
2cytochrome complex assembly (GO:0017004)5.31352222
3positive regulation of histone H3-K4 methylation (GO:0051571)5.15123441
4rRNA modification (GO:0000154)5.12173810
5respiratory chain complex IV assembly (GO:0008535)4.99018127
6protein complex biogenesis (GO:0070271)4.97113130
7maturation of SSU-rRNA (GO:0030490)4.83059388
8rRNA methylation (GO:0031167)4.82691350
9GMP metabolic process (GO:0046037)4.38891836
10positive regulation of meiosis (GO:0045836)4.36453723
11mitochondrial respiratory chain complex assembly (GO:0033108)4.30040048
12positive regulation of interleukin-17 production (GO:0032740)4.17840070
13positive regulation of natural killer cell differentiation (GO:0032825)4.17097454
14regulation of meiosis I (GO:0060631)4.16677433
15striated muscle atrophy (GO:0014891)4.04315545
16positive regulation of meiotic cell cycle (GO:0051446)4.01483142
17negative regulation of phagocytosis (GO:0050765)3.98581698
18purine nucleotide salvage (GO:0032261)3.95188049
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.86562026
20NADH dehydrogenase complex assembly (GO:0010257)3.86562026
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86562026
22DNA methylation involved in gamete generation (GO:0043046)3.83062957
23gonadal mesoderm development (GO:0007506)3.74268521
24indolalkylamine metabolic process (GO:0006586)3.70908921
25phosphorylated carbohydrate dephosphorylation (GO:0046838)3.69504247
26inositol phosphate dephosphorylation (GO:0046855)3.69504247
27skeletal muscle adaptation (GO:0043501)3.69233296
28muscle atrophy (GO:0014889)3.69022965
29organelle disassembly (GO:1903008)3.68500635
30regulation of mitochondrial translation (GO:0070129)3.64666947
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63433129
32cellular response to vitamin D (GO:0071305)3.49987455
33ribosomal small subunit assembly (GO:0000028)3.42669201
34tryptophan metabolic process (GO:0006568)3.41776705
35negative regulation of chemokine production (GO:0032682)3.38524362
36nucleotide salvage (GO:0043173)3.36732947
37positive regulation of histone methylation (GO:0031062)3.28800122
38short-chain fatty acid metabolic process (GO:0046459)3.28199813
39nucleoside salvage (GO:0043174)3.25015100
40thrombin receptor signaling pathway (GO:0070493)3.24221196
41TOR signaling (GO:0031929)3.23568484
42negative regulation of protein oligomerization (GO:0032460)3.16444806
43cellular extravasation (GO:0045123)3.13451972
44inositol phosphate catabolic process (GO:0071545)3.13404658
45ribosomal large subunit biogenesis (GO:0042273)3.10925426
46regulation of B cell receptor signaling pathway (GO:0050855)3.10541619
47negative regulation of interleukin-8 production (GO:0032717)3.10536517
48negative regulation of multicellular organism growth (GO:0040015)3.07553248
49response to pheromone (GO:0019236)3.04582094
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02867771
51regulation of natural killer cell differentiation (GO:0032823)2.95971690
52import into cell (GO:0098657)2.94183423
53interferon-gamma secretion (GO:0072643)2.91715686
54mismatch repair (GO:0006298)2.86999091
55axoneme assembly (GO:0035082)2.86936493
56pseudouridine synthesis (GO:0001522)2.85983750
57indole-containing compound catabolic process (GO:0042436)2.85563578
58indolalkylamine catabolic process (GO:0046218)2.85563578
59tryptophan catabolic process (GO:0006569)2.85563578
60cellular response to leptin stimulus (GO:0044320)2.80599467
61maternal behavior (GO:0042711)2.79233863
62DNA deamination (GO:0045006)2.78872458
63negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76411726
64photoreceptor cell maintenance (GO:0045494)2.75971970
65mannosylation (GO:0097502)2.72724396
66negative regulation of thymocyte apoptotic process (GO:0070244)2.72704290
67regulation of cilium movement (GO:0003352)2.71772581
68RNA methylation (GO:0001510)2.70242874
69positive regulation of granulocyte differentiation (GO:0030854)2.69765427
70regulation of histone H3-K4 methylation (GO:0051569)2.68784536
71epithelial cilium movement (GO:0003351)2.67007466
72ribosomal small subunit biogenesis (GO:0042274)2.64782010
73lysine catabolic process (GO:0006554)2.62995741
74lysine metabolic process (GO:0006553)2.62995741
75respiratory electron transport chain (GO:0022904)2.58985435
76natural killer cell differentiation (GO:0001779)2.56775138
77electron transport chain (GO:0022900)2.55979454
78phosphatidylinositol acyl-chain remodeling (GO:0036149)2.55828085
79parental behavior (GO:0060746)2.54760028
80N-terminal protein amino acid acetylation (GO:0006474)2.54567232
81positive regulation by host of viral transcription (GO:0043923)2.52462033
82cellular response to interferon-beta (GO:0035458)2.50626205
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50177659
84iron-sulfur cluster assembly (GO:0016226)2.49011775
85metallo-sulfur cluster assembly (GO:0031163)2.49011775
86regulation of RIG-I signaling pathway (GO:0039535)2.47514987
87purine-containing compound salvage (GO:0043101)2.47443810
88regulation of interleukin-17 production (GO:0032660)2.44049847
89regulation of interleukin-8 secretion (GO:2000482)2.43616368
90protein import into peroxisome matrix (GO:0016558)2.43284767
91prenylation (GO:0097354)2.43238839
92protein prenylation (GO:0018342)2.43238839
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.42488678
94negative regulation of response to food (GO:0032096)2.42180241
95negative regulation of appetite (GO:0032099)2.42180241
96parturition (GO:0007567)2.41808945
97chaperone-mediated protein transport (GO:0072321)2.40828632
98motile cilium assembly (GO:0044458)2.39811255
99urate metabolic process (GO:0046415)2.38668765
100regulation of histone H3-K27 methylation (GO:0061085)2.38434876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.95652702
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.02305435
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.00235873
4IGF1R_20145208_ChIP-Seq_DFB_Human3.22327821
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93699553
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.87876658
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.86715671
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84864688
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.80672569
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72357137
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69882861
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68744049
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68136610
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49851861
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.48229302
16VDR_22108803_ChIP-Seq_LS180_Human2.30224706
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.21315898
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03846758
19FOXP3_21729870_ChIP-Seq_TREG_Human2.02799720
20ER_23166858_ChIP-Seq_MCF-7_Human1.98190529
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96462312
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.96137823
23VDR_23849224_ChIP-Seq_CD4+_Human1.95960730
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95160253
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82856756
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81077278
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80094647
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74615910
29ELK1_19687146_ChIP-ChIP_HELA_Human1.72765380
30ZNF274_21170338_ChIP-Seq_K562_Hela1.71800515
31DCP1A_22483619_ChIP-Seq_HELA_Human1.63596763
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.63492728
33GBX2_23144817_ChIP-Seq_PC3_Human1.62836129
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.62479112
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.54168269
36GATA1_22025678_ChIP-Seq_K562_Human1.54065609
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52324998
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52215361
39ELF5_23300383_ChIP-Seq_T47D_Human1.51957008
40MYB_26560356_Chip-Seq_TH2_Human1.46465089
41FUS_26573619_Chip-Seq_HEK293_Human1.41103531
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40702597
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39651749
44HTT_18923047_ChIP-ChIP_STHdh_Human1.37059993
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32328854
46GATA3_26560356_Chip-Seq_TH2_Human1.32231934
47EWS_26573619_Chip-Seq_HEK293_Human1.32221342
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31661097
49KDM5A_27292631_Chip-Seq_BREAST_Human1.29670744
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28150668
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27773095
52TAF15_26573619_Chip-Seq_HEK293_Human1.27055843
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.24490816
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23275375
55STAT1_20625510_ChIP-Seq_HELA_Human1.23073941
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22429188
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.22422745
58TP53_22573176_ChIP-Seq_HFKS_Human1.21451687
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.20913114
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18199078
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17430258
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16460058
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13936374
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11238942
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07445104
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07164901
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06983884
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06137001
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04656592
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04519883
71SPI1_23547873_ChIP-Seq_NB4_Human1.04386045
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.00750148
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00643790
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99367986
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98813453
76FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98101284
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.98101284
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98057887
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97785384
80IRF8_21731497_ChIP-ChIP_J774_Mouse0.93953930
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92421451
82SCL_19346495_ChIP-Seq_HPC-7_Human0.92358240
83NANOG_19829295_ChIP-Seq_ESCs_Human0.92142761
84SOX2_19829295_ChIP-Seq_ESCs_Human0.92142761
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90554593
86AR_20517297_ChIP-Seq_VCAP_Human0.89998504
87CBP_20019798_ChIP-Seq_JUKART_Human0.89631714
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89631714
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86773298
90TTF2_22483619_ChIP-Seq_HELA_Human0.86118975
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84993602
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84495815
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83051800
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82783870
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82279238
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81871057
97CDX2_22108803_ChIP-Seq_LS180_Human0.80727951
98P53_21459846_ChIP-Seq_SAOS-2_Human0.80695556
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80391796
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79682820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.33425105
2MP0009379_abnormal_foot_pigmentation3.24442309
3MP0001986_abnormal_taste_sensitivity2.78448164
4MP0003252_abnormal_bile_duct2.69780416
5MP0002396_abnormal_hematopoietic_system2.58927502
6MP0008057_abnormal_DNA_replication2.50037320
7MP0010234_abnormal_vibrissa_follicle2.44323379
8MP0006035_abnormal_mitochondrial_morpho2.25784186
9MP0002837_dystrophic_cardiac_calcinosis2.20713233
10MP0000015_abnormal_ear_pigmentation2.20370347
11MP0002822_catalepsy2.19133895
12MP0005075_abnormal_melanosome_morpholog2.17162571
13MP0004885_abnormal_endolymph2.11319164
14MP0002876_abnormal_thyroid_physiology2.07830351
15MP0006036_abnormal_mitochondrial_physio2.07628146
16MP0008058_abnormal_DNA_repair2.05914355
17MP0005409_darkened_coat_color1.93727747
18MP0005645_abnormal_hypothalamus_physiol1.92968987
19MP0003718_maternal_effect1.87022205
20MP0005464_abnormal_platelet_physiology1.86326492
21MP0001968_abnormal_touch/_nociception1.81669011
22MP0004782_abnormal_surfactant_physiolog1.79129272
23MP0001764_abnormal_homeostasis1.69412258
24MP0003787_abnormal_imprinting1.68116649
25MP0002006_tumorigenesis1.59901858
26MP0005174_abnormal_tail_pigmentation1.57953593
27MP0010368_abnormal_lymphatic_system1.56184816
28MP0003075_altered_response_to1.55692028
29MP0001984_abnormal_olfaction1.53882872
30MP0010678_abnormal_skin_adnexa1.51419428
31MP0001661_extended_life_span1.51379550
32MP0005451_abnormal_body_composition1.51317005
33MP0002166_altered_tumor_susceptibility1.49067584
34MP0004147_increased_porphyrin_level1.45049486
35MP0001188_hyperpigmentation1.41768964
36MP0001905_abnormal_dopamine_level1.41143415
37MP0002254_reproductive_system_inflammat1.40739644
38MP0000685_abnormal_immune_system1.38751920
39MP0009780_abnormal_chondrocyte_physiolo1.34423723
40MP0004215_abnormal_myocardial_fiber1.33766154
41MP0008872_abnormal_physiological_respon1.33495802
42MP0004084_abnormal_cardiac_muscle1.33010497
43MP0005220_abnormal_exocrine_pancreas1.31763436
44MP0005647_abnormal_sex_gland1.31445464
45MP0010094_abnormal_chromosome_stability1.29842110
46MP0008775_abnormal_heart_ventricle1.29823823
47MP0002733_abnormal_thermal_nociception1.27891841
48MP0005551_abnormal_eye_electrophysiolog1.24493786
49MP0004036_abnormal_muscle_relaxation1.23939423
50MP0003183_abnormal_peptide_metabolism1.17443764
51MP0003646_muscle_fatigue1.17187806
52MP0000383_abnormal_hair_follicle1.14818772
53MP0003011_delayed_dark_adaptation1.14651444
54MP0003283_abnormal_digestive_organ1.13656747
55MP0005365_abnormal_bile_salt1.12062866
56MP0001835_abnormal_antigen_presentation1.10013944
57MP0005423_abnormal_somatic_nervous1.08296064
58MP0005085_abnormal_gallbladder_physiolo1.07695396
59MP0005165_increased_susceptibility_to1.06017816
60MP0000358_abnormal_cell_content/1.05753170
61MP0008007_abnormal_cellular_replicative1.05480821
62MP0001970_abnormal_pain_threshold1.04420954
63MP0001929_abnormal_gametogenesis1.03755703
64MP0009785_altered_susceptibility_to1.01613649
65MP0008995_early_reproductive_senescence1.01475695
66MP0002736_abnormal_nociception_after1.01020284
67MP0001944_abnormal_pancreas_morphology0.96951658
68MP0010386_abnormal_urinary_bladder0.96406054
69MP0002928_abnormal_bile_duct0.95931200
70MP0009764_decreased_sensitivity_to0.94009799
71MP0002095_abnormal_skin_pigmentation0.92821809
72MP0005266_abnormal_metabolism0.90939544
73MP0001545_abnormal_hematopoietic_system0.90507428
74MP0005397_hematopoietic_system_phenotyp0.90507428
75MP0000653_abnormal_sex_gland0.90243165
76MP0000372_irregular_coat_pigmentation0.89859260
77MP0002160_abnormal_reproductive_system0.89399800
78MP0000230_abnormal_systemic_arterial0.87444163
79MP0010329_abnormal_lipoprotein_level0.87202425
80MP0001765_abnormal_ion_homeostasis0.86475552
81MP0001819_abnormal_immune_cell0.86375870
82MP0000681_abnormal_thyroid_gland0.86224966
83MP0002693_abnormal_pancreas_physiology0.85911584
84MP0003121_genomic_imprinting0.85067113
85MP0002272_abnormal_nervous_system0.84621651
86MP0001800_abnormal_humoral_immune0.84227032
87MP0002229_neurodegeneration0.83903409
88MP0002019_abnormal_tumor_incidence0.83245210
89MP0002723_abnormal_immune_serum0.81869008
90MP0002148_abnormal_hypersensitivity_rea0.81716053
91MP0002420_abnormal_adaptive_immunity0.80333392
92MP0003638_abnormal_response/metabolism_0.79885057
93MP0005389_reproductive_system_phenotype0.79875843
94MP0001486_abnormal_startle_reflex0.79684142
95MP0001145_abnormal_male_reproductive0.79646163
96MP0004043_abnormal_pH_regulation0.78480995
97MP0005646_abnormal_pituitary_gland0.78431574
98MP0004924_abnormal_behavior0.78318401
99MP0005386_behavior/neurological_phenoty0.78318401
100MP0003436_decreased_susceptibility_to0.77010797

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.40154297
2Hepatic necrosis (HP:0002605)4.12081862
3Tubulointerstitial nephritis (HP:0001970)4.09051731
4Ragged-red muscle fibers (HP:0003200)3.94631652
5Elevated erythrocyte sedimentation rate (HP:0003565)3.86637460
6Petechiae (HP:0000967)3.75762057
7Thrombocytosis (HP:0001894)3.69977411
8B lymphocytopenia (HP:0010976)3.55907144
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.54724264
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.54724264
11Abnormality of B cell number (HP:0010975)3.42627502
12Abnormal number of erythroid precursors (HP:0012131)3.20632080
13Abnormality of the prostate (HP:0008775)3.18142591
14Mitochondrial inheritance (HP:0001427)3.11230264
15Hypoplasia of the thymus (HP:0000778)3.09722379
16Microvesicular hepatic steatosis (HP:0001414)3.06153373
17Abnormality of cells of the erythroid lineage (HP:0012130)3.04772387
18Acute lymphatic leukemia (HP:0006721)3.01222644
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84106038
20Reticulocytopenia (HP:0001896)2.81024885
21Slow saccadic eye movements (HP:0000514)2.80610004
22Increased CSF lactate (HP:0002490)2.77744341
23Type I transferrin isoform profile (HP:0003642)2.73000769
24Bile duct proliferation (HP:0001408)2.71008466
25Abnormal biliary tract physiology (HP:0012439)2.71008466
26Papilledema (HP:0001085)2.69460181
27Abnormal mitochondria in muscle tissue (HP:0008316)2.67317290
28Abnormality of macular pigmentation (HP:0008002)2.63285384
29Chromsome breakage (HP:0040012)2.60870832
30Central scotoma (HP:0000603)2.55087475
31Increased serum lactate (HP:0002151)2.52424087
32Lactic acidosis (HP:0003128)2.46193158
33Abnormality of midbrain morphology (HP:0002418)2.44457082
34Molar tooth sign on MRI (HP:0002419)2.44457082
35Constricted visual fields (HP:0001133)2.44191214
36Absent thumb (HP:0009777)2.43060358
37Pancreatic fibrosis (HP:0100732)2.42243217
38Abnormal spermatogenesis (HP:0008669)2.42103891
39Azoospermia (HP:0000027)2.41302782
40Progressive macrocephaly (HP:0004481)2.38269022
41Acute necrotizing encephalopathy (HP:0006965)2.37363901
42Neutropenia (HP:0001875)2.31112673
43Increased serum pyruvate (HP:0003542)2.27873838
44Hypoglycemic seizures (HP:0002173)2.27811508
45Abnormality of chromosome stability (HP:0003220)2.25728634
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.22741572
47Nephronophthisis (HP:0000090)2.21051126
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.20435104
49Absent/shortened dynein arms (HP:0200106)2.20435104
50Panhypogammaglobulinemia (HP:0003139)2.15743520
51Cerebral edema (HP:0002181)2.14792762
52Medial flaring of the eyebrow (HP:0010747)2.14263897
53Acute encephalopathy (HP:0006846)2.11376083
54Purpura (HP:0000979)2.10135912
55Tubulointerstitial abnormality (HP:0001969)2.09379587
56Clubbing of toes (HP:0100760)2.08935719
57IgM deficiency (HP:0002850)2.08477343
58Prostate neoplasm (HP:0100787)2.06783335
59Respiratory difficulties (HP:0002880)2.05719920
60Acute myeloid leukemia (HP:0004808)2.05360289
61Progressive muscle weakness (HP:0003323)2.03871203
62Prolonged bleeding time (HP:0003010)2.02454925
63Cone-rod dystrophy (HP:0000548)2.02412545
64Abnormality of lateral ventricle (HP:0030047)2.01167267
65Hypoglycemic coma (HP:0001325)2.00406743
66Respiratory failure (HP:0002878)2.00036444
67Increased muscle lipid content (HP:0009058)1.97788420
68Duplicated collecting system (HP:0000081)1.97020446
69Increased intramyocellular lipid droplets (HP:0012240)1.95696353
70Abnormality of DNA repair (HP:0003254)1.95215418
71Hemiparesis (HP:0001269)1.94480724
72Abnormal protein glycosylation (HP:0012346)1.93825486
73Abnormal glycosylation (HP:0012345)1.93825486
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93825486
75Abnormal protein N-linked glycosylation (HP:0012347)1.93825486
76Exercise intolerance (HP:0003546)1.93074134
77Gonadotropin excess (HP:0000837)1.92355867
78Opisthotonus (HP:0002179)1.92259199
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91190623
80Dicarboxylic aciduria (HP:0003215)1.91190623
81Emotional lability (HP:0000712)1.89880449
82Autoimmune hemolytic anemia (HP:0001890)1.86785144
83Agammaglobulinemia (HP:0004432)1.85665655
84Abnormality of the renal collecting system (HP:0004742)1.85477718
85Ketosis (HP:0001946)1.84723896
86Abnormality of the renal cortex (HP:0011035)1.83311319
87Nephrogenic diabetes insipidus (HP:0009806)1.83015551
88Abnormality of the renal medulla (HP:0100957)1.81795507
89Hip dysplasia (HP:0001385)1.81506645
90Polydipsia (HP:0001959)1.79952614
91Abnormal drinking behavior (HP:0030082)1.79952614
92Abnormality of glycolysis (HP:0004366)1.79714192
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78749488
94Anhidrosis (HP:0000970)1.78315165
95Hyperglycinemia (HP:0002154)1.78245681
96Esophageal neoplasm (HP:0100751)1.77700645
97Neoplasm of head and neck (HP:0012288)1.77700645
98Abnormal sex determination (HP:0012244)1.76955822
99Sex reversal (HP:0012245)1.76955822
100Recurrent cutaneous fungal infections (HP:0011370)1.76454099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF15.74538975
2FRK4.28307671
3RIPK44.11445422
4NUAK13.52036533
5VRK23.27635782
6TAOK33.12249232
7TRPM72.69144084
8KIT2.61018696
9BCKDK2.57100899
10MAP4K22.45920966
11BMPR22.37601938
12PIK3CG2.12154293
13FLT31.83457608
14EIF2AK11.76517179
15ERBB31.69516078
16STK241.69326541
17DAPK21.67270262
18VRK11.63820259
19STK381.55811116
20WNK41.48094624
21GRK11.42410809
22STK391.38599560
23MKNK21.33054984
24TEC1.23714090
25DAPK11.23434511
26MAP3K131.23403208
27PHKG21.23243554
28PHKG11.23243554
29TRIM281.16865586
30FGFR21.13947246
31CSF1R1.12616659
32PDK21.11946262
33PRKCQ1.05673952
34PINK11.05450682
35BRSK21.02250202
36STK161.01154179
37PASK0.99864345
38INSRR0.93497286
39TNK20.93493375
40STK38L0.92003958
41ADRBK20.91035697
42EIF2AK30.90479739
43MAP3K20.86781417
44NME20.78649088
45LATS10.77897000
46PIK3CA0.75726676
47MATK0.75310812
48ATR0.75137082
49NEK90.74799493
50PTK2B0.74347610
51MST40.73416952
52PLK30.72131356
53MAP3K140.64184055
54KSR20.64001929
55ZAK0.61971344
56ARAF0.61801996
57MKNK10.59116897
58PRKD20.58785628
59CAMK1G0.58057044
60ITK0.55914558
61CDK40.54554340
62IKBKB0.54350122
63WNK10.51948874
64PAK30.51037551
65TAOK10.48779178
66RPS6KB20.46866691
67CDC70.46597633
68CAMKK20.46213384
69CAMK1D0.45910504
70MAP3K120.44546955
71ILK0.44519691
72PLK10.44472506
73ACVR1B0.44190030
74SYK0.41387535
75FES0.39746079
76ABL20.39361573
77WNK30.37092803
78HCK0.36486804
79CCNB10.34661884
80PRKAA20.34245476
81BTK0.34230939
82TXK0.34085533
83CDK190.33496731
84CSNK2A10.33106649
85DAPK30.32735106
86STK30.32276411
87JAK30.32047398
88PDK10.31874890
89LYN0.31765172
90TBK10.30901966
91TLK10.30540477
92PRKG10.30432815
93RPS6KB10.29110601
94CSNK2A20.28528223
95PRKCH0.27796508
96PDPK10.26720746
97PRKCG0.26587012
98TTK0.26349304
99CAMK10.25742085
100NME10.25619940

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.80409829
2RNA polymerase_Homo sapiens_hsa030203.24854575
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.72742413
4Ribosome_Homo sapiens_hsa030102.71894356
5Mismatch repair_Homo sapiens_hsa034302.68149719
6Fatty acid elongation_Homo sapiens_hsa000622.54114091
7Oxidative phosphorylation_Homo sapiens_hsa001902.47957556
8Proteasome_Homo sapiens_hsa030502.21490222
9One carbon pool by folate_Homo sapiens_hsa006702.04308983
10Fanconi anemia pathway_Homo sapiens_hsa034602.00024964
11Linoleic acid metabolism_Homo sapiens_hsa005911.95439246
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.94227912
13DNA replication_Homo sapiens_hsa030301.93406303
14Basal transcription factors_Homo sapiens_hsa030221.92496931
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.85116226
16Parkinsons disease_Homo sapiens_hsa050121.79376993
17Base excision repair_Homo sapiens_hsa034101.73281932
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71339134
19Purine metabolism_Homo sapiens_hsa002301.68123553
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67676535
21Tryptophan metabolism_Homo sapiens_hsa003801.63021968
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59761662
23Dorso-ventral axis formation_Homo sapiens_hsa043201.55792082
24Pyrimidine metabolism_Homo sapiens_hsa002401.53190075
25Other glycan degradation_Homo sapiens_hsa005111.52559470
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47424176
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46683125
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35407627
29Fatty acid metabolism_Homo sapiens_hsa012121.33684961
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33266956
31Alzheimers disease_Homo sapiens_hsa050101.28725748
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28470992
33Folate biosynthesis_Homo sapiens_hsa007901.25891629
34Primary immunodeficiency_Homo sapiens_hsa053401.19129487
35ABC transporters_Homo sapiens_hsa020101.18947885
36Huntingtons disease_Homo sapiens_hsa050161.18191353
37Non-homologous end-joining_Homo sapiens_hsa034501.16963130
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15848564
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.15730899
40Propanoate metabolism_Homo sapiens_hsa006401.14419206
41RNA degradation_Homo sapiens_hsa030181.14332918
42Nucleotide excision repair_Homo sapiens_hsa034201.06182959
43Arachidonic acid metabolism_Homo sapiens_hsa005901.04061798
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.03414214
45mTOR signaling pathway_Homo sapiens_hsa041501.00828405
46Insulin secretion_Homo sapiens_hsa049111.00649546
47Peroxisome_Homo sapiens_hsa041461.00338573
48African trypanosomiasis_Homo sapiens_hsa051430.92761643
49Ether lipid metabolism_Homo sapiens_hsa005650.91310877
50RNA transport_Homo sapiens_hsa030130.88642435
51Selenocompound metabolism_Homo sapiens_hsa004500.88399192
52Asthma_Homo sapiens_hsa053100.84810512
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81593259
54Taste transduction_Homo sapiens_hsa047420.79682638
55Protein export_Homo sapiens_hsa030600.79586928
56Calcium signaling pathway_Homo sapiens_hsa040200.79015386
57Pancreatic secretion_Homo sapiens_hsa049720.77502632
58Olfactory transduction_Homo sapiens_hsa047400.77385601
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.77348184
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72855180
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.70291043
62Metabolic pathways_Homo sapiens_hsa011000.69958123
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69543110
64Regulation of autophagy_Homo sapiens_hsa041400.69245905
65Glucagon signaling pathway_Homo sapiens_hsa049220.66498084
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65835744
67Vitamin B6 metabolism_Homo sapiens_hsa007500.65283819
68Fatty acid biosynthesis_Homo sapiens_hsa000610.59182825
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.59042492
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.58615168
71Cardiac muscle contraction_Homo sapiens_hsa042600.55912079
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54630284
73B cell receptor signaling pathway_Homo sapiens_hsa046620.53457185
74Serotonergic synapse_Homo sapiens_hsa047260.52228814
75Antigen processing and presentation_Homo sapiens_hsa046120.52133003
76Type I diabetes mellitus_Homo sapiens_hsa049400.51247087
77Platelet activation_Homo sapiens_hsa046110.50650745
78Salivary secretion_Homo sapiens_hsa049700.50421751
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50274007
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46674907
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44719605
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.43456412
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41372046
84Hematopoietic cell lineage_Homo sapiens_hsa046400.40377595
85Long-term depression_Homo sapiens_hsa047300.40222783
86Pyruvate metabolism_Homo sapiens_hsa006200.39046095
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.37416020
88Retinol metabolism_Homo sapiens_hsa008300.36073686
89Chemical carcinogenesis_Homo sapiens_hsa052040.35359693
90Thyroid hormone synthesis_Homo sapiens_hsa049180.34796852
91Inositol phosphate metabolism_Homo sapiens_hsa005620.34452496
92Autoimmune thyroid disease_Homo sapiens_hsa053200.32233091
93Butanoate metabolism_Homo sapiens_hsa006500.30623202
94Allograft rejection_Homo sapiens_hsa053300.30512531
95Acute myeloid leukemia_Homo sapiens_hsa052210.30331376
96Choline metabolism in cancer_Homo sapiens_hsa052310.29200638
97Epstein-Barr virus infection_Homo sapiens_hsa051690.28936016
98Herpes simplex infection_Homo sapiens_hsa051680.28085480
99Spliceosome_Homo sapiens_hsa030400.26827610
100Nitrogen metabolism_Homo sapiens_hsa009100.26417431

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