CYB5D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.27961477
2chaperone-mediated protein transport (GO:0072321)5.97849957
3axon ensheathment in central nervous system (GO:0032291)5.47973960
4central nervous system myelination (GO:0022010)5.47973960
5glyoxylate metabolic process (GO:0046487)5.21571791
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.03662414
7behavioral response to nicotine (GO:0035095)4.69065546
8ATP synthesis coupled proton transport (GO:0015986)4.42226714
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42226714
10negative regulation of telomere maintenance (GO:0032205)4.19718556
11preassembly of GPI anchor in ER membrane (GO:0016254)4.12220295
12positive regulation of mitochondrial fission (GO:0090141)3.98545808
13inner mitochondrial membrane organization (GO:0007007)3.95585494
14GPI anchor biosynthetic process (GO:0006506)3.89260657
15nucleotide transmembrane transport (GO:1901679)3.86655730
16GPI anchor metabolic process (GO:0006505)3.82905740
17regulation of activation of Janus kinase activity (GO:0010533)3.79790441
18positive regulation of action potential (GO:0045760)3.57913494
19protein neddylation (GO:0045116)3.56265879
20pyrimidine nucleobase catabolic process (GO:0006208)3.52029167
21epithelial cilium movement (GO:0003351)3.51752679
22electron transport chain (GO:0022900)3.49963545
23long-chain fatty acid biosynthetic process (GO:0042759)3.49780927
24protein complex biogenesis (GO:0070271)3.49105788
25fatty acid elongation (GO:0030497)3.44068907
26ectoderm development (GO:0007398)3.41642152
27respiratory electron transport chain (GO:0022904)3.41277031
28cellular ketone body metabolic process (GO:0046950)3.40220656
29protein-cofactor linkage (GO:0018065)3.30475891
30oligosaccharide catabolic process (GO:0009313)3.29854997
31adenosine metabolic process (GO:0046085)3.27797563
32sequestering of actin monomers (GO:0042989)3.26564452
33import into cell (GO:0098657)3.24392869
34regulation of hexokinase activity (GO:1903299)3.24186307
35regulation of glucokinase activity (GO:0033131)3.24186307
36superoxide anion generation (GO:0042554)3.23525818
37cilium movement (GO:0003341)3.23313437
38positive regulation of meiosis (GO:0045836)3.22731281
39neurotransmitter biosynthetic process (GO:0042136)3.18293928
40intracellular protein transmembrane import (GO:0044743)3.16265513
41glycerophospholipid catabolic process (GO:0046475)3.14889869
42regulation of cilium movement (GO:0003352)3.14729472
43detection of light stimulus involved in sensory perception (GO:0050962)3.14646068
44detection of light stimulus involved in visual perception (GO:0050908)3.14646068
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14063469
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.14063469
47NADH dehydrogenase complex assembly (GO:0010257)3.14063469
48gamma-aminobutyric acid transport (GO:0015812)3.13948568
49nucleobase catabolic process (GO:0046113)3.13709875
50regulation of DNA methylation (GO:0044030)3.12789223
51mitochondrial respiratory chain complex assembly (GO:0033108)3.12301426
52male meiosis (GO:0007140)3.08949721
53neurotransmitter metabolic process (GO:0042133)3.08856086
54hydrogen ion transmembrane transport (GO:1902600)3.07846465
55cornea development in camera-type eye (GO:0061303)3.06881905
56organic cation transport (GO:0015695)3.05819378
57negative regulation of execution phase of apoptosis (GO:1900118)3.05475296
58nucleoside diphosphate catabolic process (GO:0009134)3.04472619
59negative regulation of appetite (GO:0032099)3.04202848
60negative regulation of response to food (GO:0032096)3.04202848
61positive regulation of interleukin-17 production (GO:0032740)3.00734112
62ketone body metabolic process (GO:1902224)2.99181479
63positive regulation of meiotic cell cycle (GO:0051446)2.98061770
64response to redox state (GO:0051775)2.97570784
65protein polyglutamylation (GO:0018095)2.96367099
66proton transport (GO:0015992)2.94661918
67mannosylation (GO:0097502)2.93754844
68positive regulation of cellular amine metabolic process (GO:0033240)2.92105498
69androgen biosynthetic process (GO:0006702)2.91385138
70hydrogen transport (GO:0006818)2.88775426
71polyol transport (GO:0015791)2.88258533
72presynaptic membrane assembly (GO:0097105)2.86460985
73C-terminal protein lipidation (GO:0006501)2.85023031
74pyrimidine-containing compound transmembrane transport (GO:0072531)2.83990187
75negative regulation of transcription regulatory region DNA binding (GO:2000678)2.82116359
76nucleotide transport (GO:0006862)2.81629208
77eye photoreceptor cell differentiation (GO:0001754)2.81587459
78photoreceptor cell differentiation (GO:0046530)2.81587459
79thyroid hormone generation (GO:0006590)2.81222241
80acrosome reaction (GO:0007340)2.80789976
81negative regulation of myoblast differentiation (GO:0045662)2.80593951
82central nervous system neuron axonogenesis (GO:0021955)2.80005645
83viral protein processing (GO:0019082)2.79656568
84cholesterol biosynthetic process (GO:0006695)2.78903886
85ATP biosynthetic process (GO:0006754)2.75437658
86cellular biogenic amine catabolic process (GO:0042402)2.74343385
87amine catabolic process (GO:0009310)2.74343385
88C-terminal protein amino acid modification (GO:0018410)2.72671375
89exogenous drug catabolic process (GO:0042738)2.68480620
90natural killer cell activation involved in immune response (GO:0002323)2.67341190
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.67244842
92L-phenylalanine catabolic process (GO:0006559)2.67244842
93isoprenoid biosynthetic process (GO:0008299)2.67086892
94positive regulation of protein homodimerization activity (GO:0090073)2.66908660
95positive regulation of sodium ion transmembrane transport (GO:1902307)2.66443748
96parturition (GO:0007567)2.65147809
97regulation of mitochondrial fission (GO:0090140)2.63487376
98cranial suture morphogenesis (GO:0060363)2.62782019
99presynaptic membrane organization (GO:0097090)2.60992720
100regulation of response to food (GO:0032095)2.60681211
101nonmotile primary cilium assembly (GO:0035058)2.60450883
102ATP hydrolysis coupled proton transport (GO:0015991)2.60168942
103energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.60168942
104female gonad development (GO:0008585)2.58327008
105intracellular protein transmembrane transport (GO:0065002)2.57608663
106thyroid hormone metabolic process (GO:0042403)2.57460357
107omega-hydroxylase P450 pathway (GO:0097267)2.57223490
108NAD biosynthetic process (GO:0009435)2.57138166
109myelination (GO:0042552)2.55997330
110peroxisome fission (GO:0016559)2.55984447
111water-soluble vitamin biosynthetic process (GO:0042364)2.55526960
112sphingoid metabolic process (GO:0046519)2.55179016
113regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.54941082
114positive regulation of cell fate commitment (GO:0010455)2.53980926
115positive regulation of cellular amide metabolic process (GO:0034250)2.53890946
116regulation of microtubule-based movement (GO:0060632)2.53721724
117L-amino acid import (GO:0043092)2.53350795
118purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.52413019
119regulation of platelet aggregation (GO:0090330)2.52389476
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52273331
121membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51860927
122platelet dense granule organization (GO:0060155)2.50443227
123purine nucleoside triphosphate biosynthetic process (GO:0009145)2.49627310
124regulation of telomere maintenance via telomerase (GO:0032210)2.48907222
125regulation of appetite (GO:0032098)2.48898179
126axoneme assembly (GO:0035082)2.48508405
127DNA integration (GO:0015074)2.47898753
128sterol biosynthetic process (GO:0016126)2.46116553
129ensheathment of neurons (GO:0007272)2.45833624
130axon ensheathment (GO:0008366)2.45833624
131androgen metabolic process (GO:0008209)2.45411212
132substrate-independent telencephalic tangential migration (GO:0021826)2.44829321
133substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.44829321
134response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.44049922
135photoreceptor cell maintenance (GO:0045494)2.42742848
136neuronal action potential propagation (GO:0019227)2.42409950
137dopamine transport (GO:0015872)2.41879574
138neuron cell-cell adhesion (GO:0007158)2.40712249
139postsynaptic membrane organization (GO:0001941)2.40642780
140retinal cone cell development (GO:0046549)2.40555098
141neuronal action potential (GO:0019228)2.39658967
142nitric oxide mediated signal transduction (GO:0007263)2.39097786
143protein localization to cilium (GO:0061512)2.38105707
144synaptic transmission, glutamatergic (GO:0035249)2.37323920
145adult feeding behavior (GO:0008343)2.36337487
146protein targeting to mitochondrion (GO:0006626)2.35823899
147multicellular organism reproduction (GO:0032504)2.34926042
148cilium or flagellum-dependent cell motility (GO:0001539)2.33022024
149negative regulation of cation channel activity (GO:2001258)2.32185401
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.32066559
151detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.31562989
152positive regulation of T cell mediated cytotoxicity (GO:0001916)2.30369269
153regulation of timing of cell differentiation (GO:0048505)2.30109107
154cytochrome complex assembly (GO:0017004)2.29845651
155mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.29841016
156negative regulation of neurotransmitter secretion (GO:0046929)2.29819569
157negative regulation of heart rate (GO:0010459)2.29630825
158glucuronate metabolic process (GO:0019585)2.29215157
159uronic acid metabolic process (GO:0006063)2.29215157
160positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.29199560
161glycolipid biosynthetic process (GO:0009247)2.29039608
162cell differentiation involved in metanephros development (GO:0072202)2.28891244
163oligodendrocyte differentiation (GO:0048709)2.28113113
164regulation of pigment cell differentiation (GO:0050932)2.27187769
165positive regulation of protein sumoylation (GO:0033235)2.26913814
166negative regulation of protein localization to cell surface (GO:2000009)2.25671040
167axonemal dynein complex assembly (GO:0070286)2.24371454
168regulation of action potential (GO:0098900)2.22742678
169developmental pigmentation (GO:0048066)2.22033946
170regulation of rhodopsin mediated signaling pathway (GO:0022400)2.21797002
171rhodopsin mediated signaling pathway (GO:0016056)2.20287247
172regulation of memory T cell differentiation (GO:0043380)2.20231114
173indole-containing compound catabolic process (GO:0042436)2.19673487
174indolalkylamine catabolic process (GO:0046218)2.19673487
175tryptophan catabolic process (GO:0006569)2.19673487
176cerebral cortex radially oriented cell migration (GO:0021799)2.18237835
177detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.17502312
178negative regulation of homotypic cell-cell adhesion (GO:0034111)2.15843479
179negative regulation of chemokine production (GO:0032682)2.14431201
180cellular glucuronidation (GO:0052695)2.13604573
181purine ribonucleotide transport (GO:0015868)2.13580798
182neurofilament cytoskeleton organization (GO:0060052)2.13275649
183mesenchymal cell differentiation involved in renal system development (GO:2001012)2.12410956
184mesenchymal cell differentiation involved in kidney development (GO:0072161)2.12410956
185cranial nerve development (GO:0021545)2.11277792
186glycosphingolipid catabolic process (GO:0046479)2.10992627
187G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.10314172
188limb bud formation (GO:0060174)2.09869478
189aromatic amino acid family catabolic process (GO:0009074)2.08979064
190mitochondrial calcium ion homeostasis (GO:0051560)2.07966450
191ceramide catabolic process (GO:0046514)2.07647578
192extracellular negative regulation of signal transduction (GO:1900116)2.07407281
193extracellular regulation of signal transduction (GO:1900115)2.07407281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.46165878
2ZNF274_21170338_ChIP-Seq_K562_Hela3.04434300
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98464852
4IGF1R_20145208_ChIP-Seq_DFB_Human2.94285389
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81449729
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66957318
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.60661591
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.54852049
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.47014284
10TAF15_26573619_Chip-Seq_HEK293_Human2.33637586
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.32206909
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20884876
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.15396698
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13231948
15* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10908544
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.01721259
17EZH2_27294783_Chip-Seq_NPCs_Mouse1.96330930
18VDR_22108803_ChIP-Seq_LS180_Human1.94716986
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94306636
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94218576
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92302676
22EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.86470999
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85081786
24SUZ12_18555785_Chip-Seq_ESCs_Mouse1.80516711
25STAT3_18555785_Chip-Seq_ESCs_Mouse1.77615453
26RUNX1_27457419_Chip-Seq_LIVER_Mouse1.77361318
27EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.76215686
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.76016067
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.75799979
30P53_22387025_ChIP-Seq_ESCs_Mouse1.74577166
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73987869
32REST_21632747_ChIP-Seq_MESCs_Mouse1.73715989
33E2F1_18555785_Chip-Seq_ESCs_Mouse1.71709723
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70780147
35P300_18555785_Chip-Seq_ESCs_Mouse1.69423430
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68574669
37P300_19829295_ChIP-Seq_ESCs_Human1.66682353
38NMYC_18555785_Chip-Seq_ESCs_Mouse1.66128878
39AR_21572438_ChIP-Seq_LNCaP_Human1.65342153
40CMYC_18555785_Chip-Seq_ESCs_Mouse1.63308039
41SOX2_18555785_Chip-Seq_ESCs_Mouse1.59904658
42ER_23166858_ChIP-Seq_MCF-7_Human1.59615829
43TP53_22573176_ChIP-Seq_HFKS_Human1.58947533
44SMAD1_18555785_Chip-Seq_ESCs_Mouse1.56416997
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.55756243
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.55452417
47PU1_27457419_Chip-Seq_LIVER_Mouse1.54870874
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.54354270
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.53912864
50OCT4_18555785_Chip-Seq_ESCs_Mouse1.53172752
51KLF4_18555785_Chip-Seq_ESCs_Mouse1.53082679
52ZFX_18555785_Chip-Seq_ESCs_Mouse1.52968884
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52140386
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51522351
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.51030083
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49817472
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48894108
58EWS_26573619_Chip-Seq_HEK293_Human1.48654014
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46896398
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45968997
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.43477407
62ESRRB_18555785_Chip-Seq_ESCs_Mouse1.43113165
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.42307857
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42051730
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41019101
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.40865325
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40853931
68CTCF_18555785_Chip-Seq_ESCs_Mouse1.39349111
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39276258
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37281057
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.36981356
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.36096747
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.36083714
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34862708
75OCT4_21477851_ChIP-Seq_ESCs_Mouse1.34618023
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33856901
77HTT_18923047_ChIP-ChIP_STHdh_Human1.32165253
78* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31156517
79AR_25329375_ChIP-Seq_VCAP_Human1.30609071
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30488607
81EZH2_22144423_ChIP-Seq_EOC_Human1.29864069
82BCAT_22108803_ChIP-Seq_LS180_Human1.28677031
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27886695
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25116263
85RNF2_27304074_Chip-Seq_NSC_Mouse1.25065783
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23364354
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23108837
88SMAD4_21799915_ChIP-Seq_A2780_Human1.23067718
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22811741
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22384172
91NCOR_22424771_ChIP-Seq_293T_Human1.22156453
92FUS_26573619_Chip-Seq_HEK293_Human1.21903111
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.21634379
94KDM2B_26808549_Chip-Seq_REH_Human1.20681554
95* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17587319
96* IRF1_19129219_ChIP-ChIP_H3396_Human1.16874783
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.14821884
98KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13911343
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13893633
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12114533
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10564418
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10464072
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08348192
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07458152
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06717692
106* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04429930
107* ETS1_20019798_ChIP-Seq_JURKAT_Human1.04111459
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03925778
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03054028
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02287302
111CBP_20019798_ChIP-Seq_JUKART_Human1.02287302
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02025840
113TCF4_23295773_ChIP-Seq_U87_Human1.02014087
114JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01625696
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01199745
116ERA_21632823_ChIP-Seq_H3396_Human1.00800182
117STAT1_17558387_ChIP-Seq_HELA_Human1.00625807
118POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00612530
119SRF_21415370_ChIP-Seq_HL-1_Mouse1.00572868
120TAF2_19829295_ChIP-Seq_ESCs_Human0.99429027
121FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99212646
122FOXA1_25329375_ChIP-Seq_VCAP_Human0.99212646
123AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99155294
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98038803
125EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97588241
126RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97588241
127GATA3_21878914_ChIP-Seq_MCF-7_Human0.96837959
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96746007
129NANOG_20526341_ChIP-Seq_ESCs_Human0.96003014
130MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95528542
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95242986
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94143799
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.93761285
134* RUNX2_22187159_ChIP-Seq_PCA_Human0.93375100
135NANOG_19829295_ChIP-Seq_ESCs_Human0.93295933
136SOX2_19829295_ChIP-Seq_ESCs_Human0.93295933
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92827615
138TCF4_22108803_ChIP-Seq_LS180_Human0.92183509
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91847929
140AR_20517297_ChIP-Seq_VCAP_Human0.91588969
141MYC_19829295_ChIP-Seq_ESCs_Human0.90741419
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90725668
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90302257
144PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89901608
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89268920
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89215418
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89151225
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89099657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence3.65107934
2MP0000566_synostosis3.40248117
3MP0003136_yellow_coat_color3.31152157
4MP0001986_abnormal_taste_sensitivity3.10827616
5MP0003880_abnormal_central_pattern2.90941049
6MP0005409_darkened_coat_color2.86379363
7MP0004381_abnormal_hair_follicle2.83918421
8MP0001188_hyperpigmentation2.78008586
9MP0002653_abnormal_ependyma_morphology2.77197693
10MP0006292_abnormal_olfactory_placode2.62787551
11MP0002837_dystrophic_cardiac_calcinosis2.59040743
12MP0005171_absent_coat_pigmentation2.19007625
13MP0000920_abnormal_myelination2.09132555
14MP0004142_abnormal_muscle_tone2.07258041
15MP0005551_abnormal_eye_electrophysiolog2.01269186
16MP0003950_abnormal_plasma_membrane1.97338757
17MP0002876_abnormal_thyroid_physiology1.94884906
18MP0002822_catalepsy1.94182515
19MP0004885_abnormal_endolymph1.91452079
20MP0005410_abnormal_fertilization1.88389881
21MP0008260_abnormal_autophagy1.80198831
22MP0003724_increased_susceptibility_to1.79560200
23MP0003195_calcinosis1.79075538
24MP0005423_abnormal_somatic_nervous1.78224755
25MP0009697_abnormal_copulation1.77834901
26MP0002638_abnormal_pupillary_reflex1.77114820
27MP0005646_abnormal_pituitary_gland1.77104313
28MP0006276_abnormal_autonomic_nervous1.74082332
29MP0004742_abnormal_vestibular_system1.71684188
30MP0003646_muscle_fatigue1.66591590
31MP0008872_abnormal_physiological_respon1.62818220
32MP0002064_seizures1.61261047
33MP0005379_endocrine/exocrine_gland_phen1.61138929
34MP0005451_abnormal_body_composition1.59799337
35MP0005645_abnormal_hypothalamus_physiol1.58137843
36MP0002557_abnormal_social/conspecific_i1.54712905
37MP0001502_abnormal_circadian_rhythm1.53924642
38MP0002277_abnormal_respiratory_mucosa1.50285578
39MP0002148_abnormal_hypersensitivity_rea1.49471225
40MP0002572_abnormal_emotion/affect_behav1.49142562
41MP0004859_abnormal_synaptic_plasticity1.48800885
42MP0001905_abnormal_dopamine_level1.44107714
43MP0002139_abnormal_hepatobiliary_system1.43309772
44MP0005167_abnormal_blood-brain_barrier1.41312882
45MP0003635_abnormal_synaptic_transmissio1.41252101
46MP0002234_abnormal_pharynx_morphology1.39321374
47MP0002733_abnormal_thermal_nociception1.38450714
48MP0001970_abnormal_pain_threshold1.37561233
49MP0010386_abnormal_urinary_bladder1.36173383
50MP0001529_abnormal_vocalization1.36149579
51MP0002063_abnormal_learning/memory/cond1.34414206
52MP0005085_abnormal_gallbladder_physiolo1.33177744
53MP0003786_premature_aging1.32535248
54MP0002160_abnormal_reproductive_system1.31705374
55MP0001346_abnormal_lacrimal_gland1.31621709
56MP0003941_abnormal_skin_development1.31348540
57MP0000015_abnormal_ear_pigmentation1.30751713
58MP0004147_increased_porphyrin_level1.30331626
59MP0003690_abnormal_glial_cell1.29428834
60MP0001486_abnormal_startle_reflex1.26960500
61MP0004145_abnormal_muscle_electrophysio1.26802954
62MP0000372_irregular_coat_pigmentation1.26768063
63MP0004133_heterotaxia1.25165267
64MP0002102_abnormal_ear_morphology1.23085750
65MP0001764_abnormal_homeostasis1.22969815
66MP0009785_altered_susceptibility_to1.22244126
67MP0003718_maternal_effect1.20729081
68MP0002272_abnormal_nervous_system1.20645510
69MP0003787_abnormal_imprinting1.19590798
70MP0002909_abnormal_adrenal_gland1.19023526
71MP0001440_abnormal_grooming_behavior1.18549567
72MP0001756_abnormal_urination1.17791963
73MP0000631_abnormal_neuroendocrine_gland1.17350225
74MP0009764_decreased_sensitivity_to1.16533435
75MP0010329_abnormal_lipoprotein_level1.12734390
76MP0008875_abnormal_xenobiotic_pharmacok1.12328608
77MP0002735_abnormal_chemical_nociception1.11889330
78MP0006036_abnormal_mitochondrial_physio1.11665111
79MP0005075_abnormal_melanosome_morpholog1.10141838
80MP0009046_muscle_twitch1.10127485
81MP0000026_abnormal_inner_ear1.09485650
82MP0005253_abnormal_eye_physiology1.08734872
83MP0001879_abnormal_lymphatic_vessel1.08520340
84MP0001984_abnormal_olfaction1.06211657
85MP0006072_abnormal_retinal_apoptosis1.05715773
86MP0003122_maternal_imprinting1.05051882
87MP0008877_abnormal_DNA_methylation1.04931652
88MP0005365_abnormal_bile_salt1.04286027
89MP0001664_abnormal_digestion1.03813208
90MP0002132_abnormal_respiratory_system1.02858513
91MP0005670_abnormal_white_adipose1.02313729
92MP0001963_abnormal_hearing_physiology1.01400758
93MP0005499_abnormal_olfactory_system0.99634792
94MP0005394_taste/olfaction_phenotype0.99634792
95MP0001501_abnormal_sleep_pattern0.99240462
96MP0005671_abnormal_response_to0.98453306
97MP0005647_abnormal_sex_gland0.98057891
98MP0003879_abnormal_hair_cell0.97154726
99MP0005389_reproductive_system_phenotype0.96107379
100MP0001919_abnormal_reproductive_system0.96051650
101MP0002229_neurodegeneration0.95230566
102MP0004043_abnormal_pH_regulation0.94228755
103MP0000955_abnormal_spinal_cord0.91970403
104MP0005187_abnormal_penis_morphology0.89161305
105MP0001944_abnormal_pancreas_morphology0.89147628
106MP0009379_abnormal_foot_pigmentation0.88851327
107MP0004215_abnormal_myocardial_fiber0.88713529
108MP0009780_abnormal_chondrocyte_physiolo0.88329655
109MP0001485_abnormal_pinna_reflex0.87775462
110MP0001661_extended_life_span0.87677235
111MP0004782_abnormal_surfactant_physiolog0.87320154
112MP0002752_abnormal_somatic_nervous0.87223164
113MP0005084_abnormal_gallbladder_morpholo0.86857100
114MP0009765_abnormal_xenobiotic_induced0.83707659
115MP0002734_abnormal_mechanical_nocicepti0.83415679
116MP0002163_abnormal_gland_morphology0.83225047
117MP0002882_abnormal_neuron_morphology0.82051315
118MP0002419_abnormal_innate_immunity0.81755896
119MP0004924_abnormal_behavior0.80775077
120MP0005386_behavior/neurological_phenoty0.80775077
121MP0002928_abnormal_bile_duct0.79911281
122MP0005195_abnormal_posterior_eye0.79519182
123MP0003633_abnormal_nervous_system0.79042149
124MP0002736_abnormal_nociception_after0.76822830
125MP0005174_abnormal_tail_pigmentation0.76614428
126MP0009745_abnormal_behavioral_response0.76356068
127MP0003252_abnormal_bile_duct0.75668962
128MP0002095_abnormal_skin_pigmentation0.75654296
129MP0002067_abnormal_sensory_capabilities0.75189259
130MP0002938_white_spotting0.74874814
131MP0002009_preneoplasia0.74062019
132MP0006082_CNS_inflammation0.72686337
133MP0003011_delayed_dark_adaptation0.72063815
134MP0003186_abnormal_redox_activity0.71718347
135MP0002138_abnormal_hepatobiliary_system0.70340118
136MP0005408_hypopigmentation0.69899160
137MP0004270_analgesia0.69401268
138MP0001968_abnormal_touch/_nociception0.69216688
139MP0004019_abnormal_vitamin_homeostasis0.68702924
140MP0001835_abnormal_antigen_presentation0.68677239
141MP0005395_other_phenotype0.68428780
142MP0003806_abnormal_nucleotide_metabolis0.67857321
143MP0002249_abnormal_larynx_morphology0.65275810
144MP0005332_abnormal_amino_acid0.63659152
145MP0008789_abnormal_olfactory_epithelium0.63580601
146MP0005360_urolithiasis0.63381638
147MP0000778_abnormal_nervous_system0.63205627
148MP0005387_immune_system_phenotype0.61935903
149MP0001790_abnormal_immune_system0.61935903

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.71483390
2Dynein arm defect of respiratory motile cilia (HP:0012255)3.50984512
3Absent/shortened dynein arms (HP:0200106)3.50984512
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.37057203
5Parakeratosis (HP:0001036)3.29301323
6Congenital stationary night blindness (HP:0007642)3.19571719
7Duplicated collecting system (HP:0000081)3.18088545
8Abnormality of DNA repair (HP:0003254)3.11074949
9Renal cortical cysts (HP:0000803)3.07587885
10Molar tooth sign on MRI (HP:0002419)3.05869881
11Abnormality of midbrain morphology (HP:0002418)3.05869881
12Abnormality of the renal collecting system (HP:0004742)3.03481491
13Pancreatic cysts (HP:0001737)3.01493477
143-Methylglutaconic aciduria (HP:0003535)2.96305776
15White forelock (HP:0002211)2.86384943
16Abnormal mitochondria in muscle tissue (HP:0008316)2.84169297
17Abnormality of pyrimidine metabolism (HP:0004353)2.80998447
18Aplastic anemia (HP:0001915)2.76911363
19Patchy hypopigmentation of hair (HP:0011365)2.76058436
20Abnormality of urine glucose concentration (HP:0011016)2.75448149
21Glycosuria (HP:0003076)2.75448149
22Increased CSF lactate (HP:0002490)2.74245268
23Septo-optic dysplasia (HP:0100842)2.71425335
24Abnormal respiratory motile cilium morphology (HP:0005938)2.71026866
25Abnormal respiratory epithelium morphology (HP:0012253)2.71026866
26Renal Fanconi syndrome (HP:0001994)2.69482855
27Generalized aminoaciduria (HP:0002909)2.67333340
28Gait imbalance (HP:0002141)2.66591866
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64343689
30Abnormality of the fovea (HP:0000493)2.63746814
31Unilateral renal agenesis (HP:0000122)2.63478864
32Hypothermia (HP:0002045)2.62390562
33Polyphagia (HP:0002591)2.61498016
34Anomalous pulmonary venous return (HP:0010772)2.60617971
35Increased intramyocellular lipid droplets (HP:0012240)2.59418852
36Abnormal ciliary motility (HP:0012262)2.58190746
37Abnormal hair whorl (HP:0010721)2.56256086
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52893716
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52893716
40Decreased central vision (HP:0007663)2.52526711
41Prolonged partial thromboplastin time (HP:0003645)2.49983693
42Exertional dyspnea (HP:0002875)2.46107752
43Lissencephaly (HP:0001339)2.43841986
44Absent thumb (HP:0009777)2.42514852
45Myokymia (HP:0002411)2.38433467
46Stomach cancer (HP:0012126)2.34442086
47Oral leukoplakia (HP:0002745)2.33476130
48Abnormal respiratory motile cilium physiology (HP:0012261)2.32549386
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.32116103
50Joint hemorrhage (HP:0005261)2.31283111
51Limb dystonia (HP:0002451)2.30296531
52Type II lissencephaly (HP:0007260)2.29348696
53Abnormality of renal resorption (HP:0011038)2.27320635
54Increased muscle lipid content (HP:0009058)2.25735954
55Optic nerve hypoplasia (HP:0000609)2.23199996
56Tubular atrophy (HP:0000092)2.22618551
57Abnormality of the pulmonary veins (HP:0011718)2.21753528
58Congenital sensorineural hearing impairment (HP:0008527)2.21163525
59Cerebral edema (HP:0002181)2.20608657
60Chronic hepatic failure (HP:0100626)2.20556673
61Disproportionate short-trunk short stature (HP:0003521)2.18289090
62True hermaphroditism (HP:0010459)2.18048551
63Agitation (HP:0000713)2.17617539
64Osteomalacia (HP:0002749)2.15819704
65Fair hair (HP:0002286)2.15798482
66Absent septum pellucidum (HP:0001331)2.14797144
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.14485487
68Hypoplasia of the fovea (HP:0007750)2.14485487
69Chromsome breakage (HP:0040012)2.13694937
70Abnormal drinking behavior (HP:0030082)2.12760271
71Polydipsia (HP:0001959)2.12760271
72Inability to walk (HP:0002540)2.12739318
73Submucous cleft hard palate (HP:0000176)2.12360354
74Aplasia cutis congenita (HP:0001057)2.10948028
75Keratoconus (HP:0000563)2.10854413
76Increased corneal curvature (HP:0100692)2.10854413
77Abnormality of the renal cortex (HP:0011035)2.10532500
78Increased hepatocellular lipid droplets (HP:0006565)2.09747659
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08243965
80Abnormality of incisor morphology (HP:0011063)2.08169085
81Optic disc pallor (HP:0000543)2.08071539
82Prolonged neonatal jaundice (HP:0006579)2.07407730
83Enlarged epiphyses (HP:0010580)2.07338105
84Medial flaring of the eyebrow (HP:0010747)2.07065853
85Abnormality of the septum pellucidum (HP:0007375)2.05965170
86Tubulointerstitial nephritis (HP:0001970)2.04396027
87Acute necrotizing encephalopathy (HP:0006965)2.03989645
88Abnormal rod and cone electroretinograms (HP:0008323)2.01622133
89Lactic acidosis (HP:0003128)2.00780256
90Type I transferrin isoform profile (HP:0003642)2.00677372
91Pachygyria (HP:0001302)2.00089338
92Nasolacrimal duct obstruction (HP:0000579)1.99864257
93Prostate neoplasm (HP:0100787)1.97739561
94Attenuation of retinal blood vessels (HP:0007843)1.96870726
95Sensory axonal neuropathy (HP:0003390)1.96352630
96Hemiparesis (HP:0001269)1.95749443
97Conical tooth (HP:0000698)1.95735089
98Ectopic kidney (HP:0000086)1.95421023
99Hyperventilation (HP:0002883)1.94728843
100Anhidrosis (HP:0000970)1.93509514
101Nephronophthisis (HP:0000090)1.93235372
102Cystic liver disease (HP:0006706)1.92253442
103Hypergonadotropic hypogonadism (HP:0000815)1.92190383
104Aplasia/hypoplasia of the uterus (HP:0008684)1.91994978
105Microvesicular hepatic steatosis (HP:0001414)1.91525626
106Degeneration of the lateral corticospinal tracts (HP:0002314)1.90828575
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90828575
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89750698
109Mitochondrial inheritance (HP:0001427)1.88970910
110Lipid accumulation in hepatocytes (HP:0006561)1.88723006
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88425096
112Hyperphosphaturia (HP:0003109)1.88345816
113Generalized hypopigmentation of hair (HP:0011358)1.87907313
114Genital tract atresia (HP:0001827)1.87289475
115Abnormality of the vertebral endplates (HP:0005106)1.85698422
116Methylmalonic acidemia (HP:0002912)1.85152324
117Conjugated hyperbilirubinemia (HP:0002908)1.84650761
118Abnormality of secondary sexual hair (HP:0009888)1.83073704
119Abnormality of the axillary hair (HP:0100134)1.83073704
120Progressive macrocephaly (HP:0004481)1.81208301
121Increased serum pyruvate (HP:0003542)1.80860851
122Abolished electroretinogram (ERG) (HP:0000550)1.80727907
123Hepatocellular necrosis (HP:0001404)1.79900655
124Occipital encephalocele (HP:0002085)1.79619192
125Vaginal atresia (HP:0000148)1.79455710
126Optic neuritis (HP:0100653)1.79126733
127Retrobulbar optic neuritis (HP:0100654)1.79126733
128Duplication of thumb phalanx (HP:0009942)1.79006575
129Abnormality of molar (HP:0011077)1.78797841
130Abnormality of molar morphology (HP:0011070)1.78797841
131Rhinitis (HP:0012384)1.78654589
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.77863257
133Nonprogressive disorder (HP:0003680)1.76701387
134Dry hair (HP:0011359)1.76294200
135Hypophosphatemic rickets (HP:0004912)1.76041248
136Concave nail (HP:0001598)1.75956377
137Severe muscular hypotonia (HP:0006829)1.75886258
138Ureteral duplication (HP:0000073)1.75291695
139Febrile seizures (HP:0002373)1.73632727
140Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72979664
141Muscle hypertrophy of the lower extremities (HP:0008968)1.72622291
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71116488
143Abnormality of the renal medulla (HP:0100957)1.70800720
144Hepatic necrosis (HP:0002605)1.69125578
145Thyroid-stimulating hormone excess (HP:0002925)1.67640083
146Pulmonary artery stenosis (HP:0004415)1.67509838
147Dyschromatopsia (HP:0007641)1.66558692
148Male pseudohermaphroditism (HP:0000037)1.65666497
149Nephrogenic diabetes insipidus (HP:0009806)1.64323053
150Pancreatic fibrosis (HP:0100732)1.64132699
151Acute encephalopathy (HP:0006846)1.63539660
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63046607
153Alveolar cell carcinoma (HP:0006519)1.63025145
154Upper limb muscle weakness (HP:0003484)1.62546831
155Congenital primary aphakia (HP:0007707)1.62494444
156Adrenal hypoplasia (HP:0000835)1.61221858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.28151006
2TNIK3.25395162
3CASK3.17491181
4ZAK3.08508944
5MAP4K12.71435931
6IRAK22.62839315
7PRPF4B2.56060166
8STK162.51892144
9IRAK32.44447028
10STK392.41559939
11NEK62.41165999
12IRAK42.35528819
13MAP4K22.22246189
14MARK12.18937004
15MUSK2.18795785
16PBK2.17555657
17INSRR2.12262273
18ADRBK22.05479319
19OXSR11.95801941
20GRK71.93362962
21MAP3K41.82820594
22PKN11.79851604
23TXK1.78771634
24YES11.64592989
25FRK1.62372414
26VRK21.60684239
27TNK21.57552455
28MAP3K141.52436410
29BMPR1B1.50716412
30IRAK11.47997119
31MKNK21.43171301
32CDK31.40071087
33MAP2K71.34867015
34GRK11.34843822
35TESK11.34799057
36EIF2AK21.32204351
37MKNK11.31526834
38BCR1.31367966
39BMPR21.29395808
40PINK11.26904729
41DAPK21.23241427
42MAPKAPK51.18301683
43MAPK151.14089944
44SGK4941.13686692
45SGK2231.13686692
46PRKCG1.12488110
47AKT31.11893461
48TEC1.05519023
49CSNK1G11.05264061
50MAP2K41.03840917
51NUAK11.02356957
52MAP3K111.01553311
53CSNK1G20.99442872
54IKBKE0.99184226
55MAP3K120.97098089
56PIM20.96334066
57MST40.94690362
58CAMKK20.93331655
59NTRK30.90411664
60STK38L0.90192864
61MINK10.89409083
62TESK20.89315275
63GRK50.89176471
64WNK40.87322170
65TRPM70.85909394
66NTRK20.84405258
67MAPK70.82801580
68ERBB40.82420102
69PAK30.79481699
70IKBKB0.77381549
71PRKCE0.75993216
72BCKDK0.75990429
73CAMK2D0.75353507
74PDK20.74812780
75ADRBK10.74698304
76EPHA40.74331166
77TIE10.73183421
78STK110.73015561
79PIK3CA0.70698850
80DYRK30.70679884
81MAPK130.69662476
82PIK3CG0.68569371
83NLK0.68417953
84BLK0.68340845
85SGK20.67953189
86ERBB30.67467584
87DYRK20.66828013
88DAPK30.66556731
89PNCK0.65505082
90SRPK10.65044280
91TRIM280.64237053
92ZAP700.64160664
93PRKD30.64114764
94MAPKAPK30.63641399
95OBSCN0.63615287
96SIK30.62829437
97CAMK2B0.61613502
98EPHB10.61244187
99KIT0.60218656
100VRK10.60209090
101CAMK2G0.58540084
102RPS6KA50.58488295
103PRKCQ0.58488185
104WNK30.55159703
105CAMK2A0.54528885
106RIPK40.54273036
107PTK2B0.53459615
108LIMK10.53293616
109ERBB20.51682736
110CLK10.50034024
111DAPK10.49895480
112PRKAA10.49012637
113CSNK1A10.48927389
114LMTK20.46763880
115EPHB20.45851747
116LYN0.45213248
117EPHA30.45162409
118FLT30.45045953
119WNK10.44105497
120PRKG10.42395373
121BRAF0.41993230
122PHKG20.41756120
123PHKG10.41756120
124BTK0.40630405
125PRKACA0.39862459
126MYLK0.39819260
127PRKCA0.37771788
128ILK0.37206520
129NEK90.36816940
130PLK40.36775532
131CSNK1A1L0.36728128
132MAP3K50.36048484
133PLK20.35385185
134TLK10.33459887
135CSK0.32786548
136FER0.32615030
137FES0.31749600
138CDK50.31570501
139UHMK10.30386397
140IGF1R0.29277400
141LCK0.27862119
142CAMK10.27070589
143DYRK1A0.26858941
144CSNK1G30.26766328
145CHUK0.26505847
146MAPK120.26178299
147BRD40.26166183
148PRKAA20.25189517
149ABL10.25094148
150PRKCD0.25068962
151SGK10.24195867

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.23387446
2Steroid biosynthesis_Homo sapiens_hsa001003.11986600
3Fatty acid elongation_Homo sapiens_hsa000623.06697274
4Vitamin B6 metabolism_Homo sapiens_hsa007502.65187874
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.49193320
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.33271540
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27491398
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18265228
9Sphingolipid metabolism_Homo sapiens_hsa006002.11232824
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.03039563
11Cardiac muscle contraction_Homo sapiens_hsa042601.99894386
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.99763916
13Phototransduction_Homo sapiens_hsa047441.97111764
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94282420
15Ether lipid metabolism_Homo sapiens_hsa005651.89005538
16Peroxisome_Homo sapiens_hsa041461.88751956
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81331344
18Oxidative phosphorylation_Homo sapiens_hsa001901.79579831
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79034518
20Sulfur metabolism_Homo sapiens_hsa009201.76152539
21Arachidonic acid metabolism_Homo sapiens_hsa005901.69168410
22Retinol metabolism_Homo sapiens_hsa008301.63800804
23Protein export_Homo sapiens_hsa030601.63524894
24Histidine metabolism_Homo sapiens_hsa003401.63426816
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58213172
26Linoleic acid metabolism_Homo sapiens_hsa005911.58128856
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57991342
28Synaptic vesicle cycle_Homo sapiens_hsa047211.53485826
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53246072
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46136348
31Olfactory transduction_Homo sapiens_hsa047401.45392732
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44540474
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43420994
34Autoimmune thyroid disease_Homo sapiens_hsa053201.42144889
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40525103
36Graft-versus-host disease_Homo sapiens_hsa053321.39105603
37Ribosome_Homo sapiens_hsa030101.34998374
38Allograft rejection_Homo sapiens_hsa053301.33819115
39Basal transcription factors_Homo sapiens_hsa030221.31987118
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27800635
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27561677
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26282921
43Chemical carcinogenesis_Homo sapiens_hsa052041.25801204
44Insulin secretion_Homo sapiens_hsa049111.23822376
45Fanconi anemia pathway_Homo sapiens_hsa034601.23338531
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19037426
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.18016158
48Nitrogen metabolism_Homo sapiens_hsa009101.17506478
49Circadian entrainment_Homo sapiens_hsa047131.15604818
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15185918
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13603966
52beta-Alanine metabolism_Homo sapiens_hsa004101.13436928
53Butanoate metabolism_Homo sapiens_hsa006501.11432296
54Propanoate metabolism_Homo sapiens_hsa006401.09985363
55Glutamatergic synapse_Homo sapiens_hsa047241.09598291
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08835364
57Rheumatoid arthritis_Homo sapiens_hsa053231.06154532
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06145892
59Fatty acid metabolism_Homo sapiens_hsa012121.05853147
60Tryptophan metabolism_Homo sapiens_hsa003801.04570287
61Caffeine metabolism_Homo sapiens_hsa002321.04204486
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01695183
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00734902
64Vitamin digestion and absorption_Homo sapiens_hsa049770.99308483
65ABC transporters_Homo sapiens_hsa020100.98979436
66Parkinsons disease_Homo sapiens_hsa050120.97078973
67Alzheimers disease_Homo sapiens_hsa050100.95070285
68Arginine and proline metabolism_Homo sapiens_hsa003300.93674236
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.92439719
70Homologous recombination_Homo sapiens_hsa034400.87374652
71Pyruvate metabolism_Homo sapiens_hsa006200.86082873
72Complement and coagulation cascades_Homo sapiens_hsa046100.85547891
73Other glycan degradation_Homo sapiens_hsa005110.85407682
74Staphylococcus aureus infection_Homo sapiens_hsa051500.85086470
75Fatty acid biosynthesis_Homo sapiens_hsa000610.84980140
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83334182
77Metabolic pathways_Homo sapiens_hsa011000.82866886
78Tyrosine metabolism_Homo sapiens_hsa003500.82792034
79Huntingtons disease_Homo sapiens_hsa050160.81986501
80Non-homologous end-joining_Homo sapiens_hsa034500.81019432
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.80368124
82Nicotine addiction_Homo sapiens_hsa050330.79508508
83Dopaminergic synapse_Homo sapiens_hsa047280.77967154
84Ovarian steroidogenesis_Homo sapiens_hsa049130.77168523
85Salivary secretion_Homo sapiens_hsa049700.76526805
86Fatty acid degradation_Homo sapiens_hsa000710.75947884
87Serotonergic synapse_Homo sapiens_hsa047260.73080056
88Cocaine addiction_Homo sapiens_hsa050300.70455674
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70000117
90Glutathione metabolism_Homo sapiens_hsa004800.69473978
91Starch and sucrose metabolism_Homo sapiens_hsa005000.68715100
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.68368999
93Regulation of autophagy_Homo sapiens_hsa041400.65568688
94Selenocompound metabolism_Homo sapiens_hsa004500.65090999
95Taste transduction_Homo sapiens_hsa047420.65051530
96Vibrio cholerae infection_Homo sapiens_hsa051100.63223118
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62669776
98Amphetamine addiction_Homo sapiens_hsa050310.61464889
99Proteasome_Homo sapiens_hsa030500.60646070
100RNA polymerase_Homo sapiens_hsa030200.58488011
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55797653
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.55566306
103Folate biosynthesis_Homo sapiens_hsa007900.55457265
104Malaria_Homo sapiens_hsa051440.54642737
105Hematopoietic cell lineage_Homo sapiens_hsa046400.52809770
106Phenylalanine metabolism_Homo sapiens_hsa003600.51520305
107Bile secretion_Homo sapiens_hsa049760.51403439
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.50135368
109Long-term depression_Homo sapiens_hsa047300.48007278
110Collecting duct acid secretion_Homo sapiens_hsa049660.47415409
111Gastric acid secretion_Homo sapiens_hsa049710.45804110
112Purine metabolism_Homo sapiens_hsa002300.44458566
113Asthma_Homo sapiens_hsa053100.43089705
114Circadian rhythm_Homo sapiens_hsa047100.42706569
115Calcium signaling pathway_Homo sapiens_hsa040200.41193325
116African trypanosomiasis_Homo sapiens_hsa051430.41004629
117Type I diabetes mellitus_Homo sapiens_hsa049400.40380421
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.39307001
119Morphine addiction_Homo sapiens_hsa050320.38598577
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38595254
121Alcoholism_Homo sapiens_hsa050340.37596182
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36491010
123Primary immunodeficiency_Homo sapiens_hsa053400.36296943
124PPAR signaling pathway_Homo sapiens_hsa033200.34591164
125Phagosome_Homo sapiens_hsa041450.33604679
126Pancreatic secretion_Homo sapiens_hsa049720.33478811
127Cholinergic synapse_Homo sapiens_hsa047250.33463796
128GABAergic synapse_Homo sapiens_hsa047270.31800397
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31720223
130Pyrimidine metabolism_Homo sapiens_hsa002400.30751268
131Sulfur relay system_Homo sapiens_hsa041220.29746315
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29583346
133Fat digestion and absorption_Homo sapiens_hsa049750.29452649

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