CYB5D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)6.85583738
2axoneme assembly (GO:0035082)6.84372659
3regulation of cilium movement (GO:0003352)6.34105017
4ventricular system development (GO:0021591)6.22592420
5intraciliary transport (GO:0042073)5.53777270
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.38487923
7L-phenylalanine catabolic process (GO:0006559)5.38487923
8alpha-linolenic acid metabolic process (GO:0036109)5.28113204
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.21524174
10L-phenylalanine metabolic process (GO:0006558)5.21524174
11lysine metabolic process (GO:0006553)5.08809207
12lysine catabolic process (GO:0006554)5.08809207
13negative regulation of fibrinolysis (GO:0051918)5.08533536
14cilium organization (GO:0044782)4.97901509
15microtubule bundle formation (GO:0001578)4.91041450
16cilium assembly (GO:0042384)4.88787785
17aromatic amino acid family catabolic process (GO:0009074)4.84158579
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81636518
19centriole assembly (GO:0098534)4.78807819
20kynurenine metabolic process (GO:0070189)4.65800451
21left/right axis specification (GO:0070986)4.63723719
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.58612570
23bile acid biosynthetic process (GO:0006699)4.48553299
24protein carboxylation (GO:0018214)4.43656795
25peptidyl-glutamic acid carboxylation (GO:0017187)4.43656795
26regulation of protein activation cascade (GO:2000257)4.42339384
27primary alcohol catabolic process (GO:0034310)4.39333391
28positive regulation of fatty acid beta-oxidation (GO:0032000)4.37048263
29urea cycle (GO:0000050)4.36069255
30urea metabolic process (GO:0019627)4.36069255
31tryptophan catabolic process (GO:0006569)4.35612510
32indole-containing compound catabolic process (GO:0042436)4.35612510
33indolalkylamine catabolic process (GO:0046218)4.35612510
34establishment of apical/basal cell polarity (GO:0035089)4.34871639
35glyoxylate metabolic process (GO:0046487)4.34672826
36microtubule-based movement (GO:0007018)4.23989805
37regulation of fatty acid beta-oxidation (GO:0031998)4.23552982
38sulfur amino acid catabolic process (GO:0000098)4.21414557
39regulation of fibrinolysis (GO:0051917)4.20917774
40regulation of complement activation (GO:0030449)4.20206286
41tryptophan metabolic process (GO:0006568)4.19109089
422-oxoglutarate metabolic process (GO:0006103)4.17935513
43microtubule depolymerization (GO:0007019)4.16267321
44sperm capacitation (GO:0048240)4.10085493
45high-density lipoprotein particle remodeling (GO:0034375)4.09570339
46complement activation, alternative pathway (GO:0006957)4.09119154
47establishment of monopolar cell polarity (GO:0061162)4.06097514
48establishment or maintenance of monopolar cell polarity (GO:0061339)4.06097514
49regulation of triglyceride catabolic process (GO:0010896)4.05923850
50amino-acid betaine metabolic process (GO:0006577)4.04116666
51glomerular epithelial cell development (GO:0072310)3.96770766
52dicarboxylic acid biosynthetic process (GO:0043650)3.95908571
53cysteine metabolic process (GO:0006534)3.93749476
54negative regulation of cholesterol transport (GO:0032375)3.92613090
55negative regulation of sterol transport (GO:0032372)3.92613090
56serine family amino acid catabolic process (GO:0009071)3.91563235
57centriole replication (GO:0007099)3.86122103
58cellular component assembly involved in morphogenesis (GO:0010927)3.81568234
59oxaloacetate metabolic process (GO:0006107)3.81069209
60nitrogen cycle metabolic process (GO:0071941)3.79095193
61aspartate family amino acid catabolic process (GO:0009068)3.75489762
62bile acid metabolic process (GO:0008206)3.75438714
63alpha-amino acid catabolic process (GO:1901606)3.71964132
64valine metabolic process (GO:0006573)3.67396080
65protein localization to cilium (GO:0061512)3.66970812
66positive regulation of lipid catabolic process (GO:0050996)3.65363966
67homocysteine metabolic process (GO:0050667)3.64135599
68glycine metabolic process (GO:0006544)3.60011365
69reverse cholesterol transport (GO:0043691)3.59440813
70regulation of microtubule-based movement (GO:0060632)3.57786216
71vitamin transmembrane transport (GO:0035461)3.55884904
72Golgi transport vesicle coating (GO:0048200)3.53857646
73COPI coating of Golgi vesicle (GO:0048205)3.53857646
74lateral ventricle development (GO:0021670)3.52486832
75cellular modified amino acid catabolic process (GO:0042219)3.50810856
76tricarboxylic acid cycle (GO:0006099)3.49106333
77glutamate metabolic process (GO:0006536)3.48933067
78plasma lipoprotein particle clearance (GO:0034381)3.48382599
79cellular amino acid catabolic process (GO:0009063)3.47670708
80microtubule polymerization or depolymerization (GO:0031109)3.47647148
81cilium morphogenesis (GO:0060271)3.46834961
82positive regulation of fatty acid oxidation (GO:0046321)3.45257696
83triglyceride homeostasis (GO:0070328)3.44984306
84acylglycerol homeostasis (GO:0055090)3.44984306
85pyrimidine-containing compound transmembrane transport (GO:0072531)3.42561085
86aromatic amino acid family metabolic process (GO:0009072)3.40823563
87regulation of cholesterol homeostasis (GO:2000188)3.40429362
88sperm motility (GO:0030317)3.39071003
89fatty acid beta-oxidation (GO:0006635)3.37568257
90succinate metabolic process (GO:0006105)3.37419390
91fatty acid homeostasis (GO:0055089)3.34617619
924-hydroxyproline metabolic process (GO:0019471)3.33733508
93ethanol metabolic process (GO:0006067)3.31450806
94cell projection assembly (GO:0030031)3.31248378
95short-chain fatty acid metabolic process (GO:0046459)3.30896491
96protein-lipid complex remodeling (GO:0034368)3.30105374
97macromolecular complex remodeling (GO:0034367)3.30105374
98plasma lipoprotein particle remodeling (GO:0034369)3.30105374
99tyrosine metabolic process (GO:0006570)3.29342411
100diterpenoid biosynthetic process (GO:0016102)3.28213559
101nucleoside diphosphate phosphorylation (GO:0006165)3.27221853
102ethanol oxidation (GO:0006069)3.26128380
103lung epithelium development (GO:0060428)3.25281831
104serine family amino acid metabolic process (GO:0009069)3.24521364
105negative regulation of protein activation cascade (GO:2000258)3.24156738
106phospholipid efflux (GO:0033700)3.23834955
107serine family amino acid biosynthetic process (GO:0009070)3.23069108
108acetyl-CoA metabolic process (GO:0006084)3.21135351
109fatty acid oxidation (GO:0019395)3.20773613
110regulation of cholesterol esterification (GO:0010872)3.19383291
111regulation of fatty acid oxidation (GO:0046320)3.18676276
112regulation of translational termination (GO:0006449)3.17631256
113negative regulation of T cell differentiation in thymus (GO:0033085)3.17231366
114tricarboxylic acid metabolic process (GO:0072350)3.16553660
115phospholipid homeostasis (GO:0055091)3.16274001
116fatty acid transmembrane transport (GO:1902001)3.15702785
117monocarboxylic acid catabolic process (GO:0072329)3.12951093
118fatty acid catabolic process (GO:0009062)3.12694371
119lipid oxidation (GO:0034440)3.12439048
120arginine metabolic process (GO:0006525)3.11820859
121positive regulation of fatty acid metabolic process (GO:0045923)3.09971397
122cellular ketone body metabolic process (GO:0046950)3.09807030
123low-density lipoprotein particle clearance (GO:0034383)3.07707117
124regulation of plasminogen activation (GO:0010755)3.06204609
125epoxygenase P450 pathway (GO:0019373)3.05913142
126negative regulation of fatty acid biosynthetic process (GO:0045717)3.05872569
127organic acid catabolic process (GO:0016054)3.05656090
128carboxylic acid catabolic process (GO:0046395)3.05656090
129fibrinolysis (GO:0042730)3.05558704
130positive regulation of glycogen biosynthetic process (GO:0045725)3.02835254
131macroautophagy (GO:0016236)3.02737385
132establishment of tissue polarity (GO:0007164)3.00355220
133establishment of planar polarity (GO:0001736)3.00355220
134imidazole-containing compound metabolic process (GO:0052803)2.99745601
135positive regulation of glycolytic process (GO:0045821)2.99705735
136plasma lipoprotein particle assembly (GO:0034377)2.98289176
137nonmotile primary cilium assembly (GO:0035058)2.81083624
138phenol-containing compound catabolic process (GO:0019336)2.81072084
139determination of left/right symmetry (GO:0007368)2.76301889
140positive regulation of smoothened signaling pathway (GO:0045880)2.75929955
141microtubule-based process (GO:0007017)2.72737467
142embryonic camera-type eye development (GO:0031076)2.68714323
143specification of symmetry (GO:0009799)2.67393412
144determination of bilateral symmetry (GO:0009855)2.66629260
145apical protein localization (GO:0045176)2.63820455
146cytoplasmic microtubule organization (GO:0031122)2.63201102
147regulation of interleukin-5 production (GO:0032674)2.57705238
148carnitine metabolic process (GO:0009437)2.56218607
149thyroid hormone generation (GO:0006590)2.50323208
150smoothened signaling pathway (GO:0007224)2.50083253
151lateral sprouting from an epithelium (GO:0060601)2.49557259
152organelle assembly (GO:0070925)2.49221733
153embryonic heart tube morphogenesis (GO:0003143)2.48051928
154negative regulation of humoral immune response (GO:0002921)2.47729462
155heart looping (GO:0001947)2.46953400
156camera-type eye morphogenesis (GO:0048593)2.45533802
157paraxial mesoderm development (GO:0048339)2.44646937
158establishment or maintenance of apical/basal cell polarity (GO:0035088)2.44069445
159establishment or maintenance of bipolar cell polarity (GO:0061245)2.44069445
160spermatid development (GO:0007286)2.42226908
161asymmetric protein localization (GO:0008105)2.41196221
162negative regulation of inclusion body assembly (GO:0090084)2.38994688
163embryonic heart tube development (GO:0035050)2.35208302
164chaperone-mediated protein complex assembly (GO:0051131)2.32504248
165negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31359595
166chromosome condensation (GO:0030261)2.30281403
167phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.27905432
168regulation of microtubule depolymerization (GO:0031114)2.27889957
169one-carbon compound transport (GO:0019755)2.25863224
170regulation of interleukin-13 production (GO:0032656)2.25429702
171embryonic body morphogenesis (GO:0010172)2.24287176
172retinoic acid metabolic process (GO:0042573)2.24263277
173CDP-diacylglycerol biosynthetic process (GO:0016024)2.23641295
174negative regulation of immunoglobulin mediated immune response (GO:0002890)2.17521800
175negative regulation of B cell mediated immunity (GO:0002713)2.17521800
176body morphogenesis (GO:0010171)2.15943312
177terpenoid biosynthetic process (GO:0016114)2.12718152
178response to xenobiotic stimulus (GO:0009410)2.11968356
179regulation of smoothened signaling pathway (GO:0008589)2.11403904
180iron ion import (GO:0097286)2.10377770
181microtubule severing (GO:0051013)2.07941496
182excretion (GO:0007588)2.03514358
183intra-S DNA damage checkpoint (GO:0031573)2.03163078
184blastocyst development (GO:0001824)2.03053576
185protein polyglutamylation (GO:0018095)2.01781012
186nuclear pore complex assembly (GO:0051292)2.01388548
187negative regulation of microtubule depolymerization (GO:0007026)2.01150331
188substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.00722744
189substrate-independent telencephalic tangential migration (GO:0021826)2.00722744
190planar cell polarity pathway involved in neural tube closure (GO:0090179)2.00140567
191axonemal dynein complex assembly (GO:0070286)16.7213931
192cilium or flagellum-dependent cell motility (GO:0001539)12.9926492
193motile cilium assembly (GO:0044458)12.4106905
194cilium movement (GO:0003341)12.2680509
195epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.6790063
196epithelial cilium movement (GO:0003351)11.3971012
197CDP-diacylglycerol metabolic process (GO:0046341)1.99849726
198protein refolding (GO:0042026)1.99745780
199embryonic retina morphogenesis in camera-type eye (GO:0060059)1.97208078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.67959154
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.99705389
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.48448879
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.94403892
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.61777041
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.18136251
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.84497464
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.68327069
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.64955142
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.33203910
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.14844993
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.13219452
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.90236783
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.81137851
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.73096695
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68483598
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.56197007
18CLOCK_20551151_ChIP-Seq_293T_Human2.50554684
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46944203
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40841442
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38566994
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.37157851
23PIAS1_25552417_ChIP-Seq_VCAP_Human2.28539790
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03356281
25GATA1_26923725_Chip-Seq_HPCs_Mouse2.01563983
26ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00437263
27FOXM1_26456572_ChIP-Seq_MCF-7_Human1.98209806
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85651711
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.79081473
30CTNNB1_20460455_ChIP-Seq_HCT116_Human1.78818332
31AHR_22903824_ChIP-Seq_MCF-7_Human1.74894419
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.70322206
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68748790
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.67923482
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63390263
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.61301397
37MYC_22102868_ChIP-Seq_BL_Human1.54177021
38* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54139166
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.51936547
40FUS_26573619_Chip-Seq_HEK293_Human1.46635510
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44818023
42TP53_18474530_ChIP-ChIP_U2OS_Human1.40223969
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39682191
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.39662978
45* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37140355
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36278387
47CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35547183
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31401220
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.30955736
50* RUNX1_27514584_Chip-Seq_MCF-7_Human1.30835706
51FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.30319907
52CHD1_26751641_Chip-Seq_LNCaP_Human1.30277222
53SMAD4_21799915_ChIP-Seq_A2780_Human1.27814632
54AR_21572438_ChIP-Seq_LNCaP_Human1.25817943
55HNF4A_19822575_ChIP-Seq_HepG2_Human1.25611556
56FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.24175489
57DROSHA_22980978_ChIP-Seq_HELA_Human1.23308672
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21107499
59FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.20550861
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19404141
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18948074
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.18531589
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.18531589
64STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17794749
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17361064
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17073047
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15678205
68PHF8_20622853_ChIP-Seq_HELA_Human1.15192715
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15114551
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14617833
71CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14060903
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14002582
73TBL1_22424771_ChIP-Seq_293T_Human1.12252506
74TP63_23658742_ChIP-Seq_EP156T_Human1.11867476
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11861306
76HNFA_21074721_ChIP-Seq_CACO-2_Human1.11254344
77* WT1_19549856_ChIP-ChIP_CCG9911_Human1.09427192
78E2F1_17053090_ChIP-ChIP_MCF-7_Human1.08755465
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.08299258
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.06467076
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06439933
82GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.04862136
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03297329
84RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02928952
85ETV1_20927104_ChIP-Seq_GIST48_Human1.02792352
86LXR_22292898_ChIP-Seq_THP-1_Human1.01958919
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.01909038
88GATA3_24758297_ChIP-Seq_MCF-7_Human1.01532576
89CBP_20019798_ChIP-Seq_JUKART_Human1.00659983
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00659983
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99698166
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99660004
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99496074
94CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97441465
95EWS_26573619_Chip-Seq_HEK293_Human0.97114773
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96789650
97NFYB_21822215_ChIP-Seq_K562_Human0.96382599
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96091146
99CREB1_26743006_Chip-Seq_LNCaP_Human0.95737353
100TP53_16413492_ChIP-PET_HCT116_Human0.95594948
101WDR5_24793694_ChIP-Seq_LNCAP_Human0.95452713
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95366820
103ATF3_27146783_Chip-Seq_COLON_Human0.94871476
104KLF5_25053715_ChIP-Seq_YYC3_Human0.94103775
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.94002189
106NCOR1_26117541_ChIP-Seq_K562_Human0.93764558
107PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93015390
108CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92763890
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92675310
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.92513235
111NFYA_21822215_ChIP-Seq_K562_Human0.91625283
112* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91433397
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.90721593
114GF1B_26923725_Chip-Seq_HPCs_Mouse0.89730447
115TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89398538
116SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88963561
117ELF1_20517297_ChIP-Seq_JURKAT_Human0.88880306
118SMC4_20622854_ChIP-Seq_HELA_Human0.88286023
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86740859
120TP63_17297297_ChIP-ChIP_HaCaT_Human0.85794934
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85637359
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85637359
123E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85431852
124AR_19668381_ChIP-Seq_PC3_Human0.85158759
125RXR_22108803_ChIP-Seq_LS180_Human0.85052304
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84904806
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84711199
128* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.84633513
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83675107
130GATA1_19941826_ChIP-Seq_K562_Human0.83015293
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82832338
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82374214
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81900504
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.80567411
135ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80311858
136GATA2_19941826_ChIP-Seq_K562_Human0.79881415
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79875242
138ELK3_25401928_ChIP-Seq_HUVEC_Human0.79810881
139TCF7_22412390_ChIP-Seq_EML_Mouse0.79769455
140AR_21909140_ChIP-Seq_LNCAP_Human0.78371945
141KDM2B_26808549_Chip-Seq_DND41_Human0.78149865
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78050221
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77958639
144SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77145789
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77001096
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75744638
147EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.75000953
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74527663
149STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73433860
150PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73295021
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72480990
152DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.72254134
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72109516
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72108556
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71164435
156SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70807755
157CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.70289346
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69821221
159ZNF263_19887448_ChIP-Seq_K562_Human0.69428895
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69401229
161* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.69033475
162KDM2B_26808549_Chip-Seq_SUP-B15_Human0.68887981
163FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67344042
164ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.67334293
165NANOG_21062744_ChIP-ChIP_HESCs_Human0.66042149
166AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65800885
167FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64887161
168TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.63437158
169UTX_26944678_Chip-Seq_JUKART_Human0.63163913
170GATA3_26560356_Chip-Seq_TH1_Human0.63109684
171GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.62221181
172ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.62016354
173MYB_21317192_ChIP-Seq_ERMYB_Mouse0.61896911
174ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.61819875
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61379869
176EP300_21415370_ChIP-Seq_HL-1_Mouse0.60924854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.59151411
2MP0005360_urolithiasis5.95013223
3MP0005365_abnormal_bile_salt5.12038469
4MP0005085_abnormal_gallbladder_physiolo5.01041905
5MP0003806_abnormal_nucleotide_metabolis3.92254195
6MP0003705_abnormal_hypodermis_morpholog3.63618355
7MP0008875_abnormal_xenobiotic_pharmacok3.57898982
8MP0010329_abnormal_lipoprotein_level3.24055665
9MP0003252_abnormal_bile_duct3.21928600
10MP0008789_abnormal_olfactory_epithelium3.19006319
11MP0001984_abnormal_olfaction3.16162048
12MP0000566_synostosis3.04261917
13MP0002132_abnormal_respiratory_system2.91004189
14MP0005499_abnormal_olfactory_system2.78297649
15MP0005394_taste/olfaction_phenotype2.78297649
16MP0010030_abnormal_orbit_morphology2.75438828
17MP0005083_abnormal_biliary_tract2.69497654
18MP0009840_abnormal_foam_cell2.53558925
19MP0002837_dystrophic_cardiac_calcinosis2.49489019
20MP0001346_abnormal_lacrimal_gland2.15208905
21MP0004043_abnormal_pH_regulation2.07615229
22MP0000609_abnormal_liver_physiology2.07428287
23MP0005248_abnormal_Harderian_gland2.06340511
24MP0005332_abnormal_amino_acid2.04640856
25MP0004133_heterotaxia2.02306375
26MP0010368_abnormal_lymphatic_system1.96039809
27MP0004130_abnormal_muscle_cell1.91345363
28MP0002282_abnormal_trachea_morphology1.82439095
29MP0002118_abnormal_lipid_homeostasis1.75048972
30MP0005319_abnormal_enzyme/_coenzyme1.74026559
31MP0003191_abnormal_cellular_cholesterol1.73208480
32MP0003878_abnormal_ear_physiology1.58726777
33MP0005377_hearing/vestibular/ear_phenot1.58726777
34MP0010234_abnormal_vibrissa_follicle1.58190758
35MP0002249_abnormal_larynx_morphology1.57897486
36MP0003937_abnormal_limbs/digits/tail_de1.57849706
37MP0005670_abnormal_white_adipose1.56891275
38MP0003136_yellow_coat_color1.56632695
39MP0005647_abnormal_sex_gland1.55517652
40MP0001666_abnormal_nutrient_absorption1.51421030
41MP0003195_calcinosis1.50140061
42MP0010678_abnormal_skin_adnexa1.48667554
43MP0000013_abnormal_adipose_tissue1.48023754
44MP0000383_abnormal_hair_follicle1.47354596
45MP0009780_abnormal_chondrocyte_physiolo1.46665118
46MP0004084_abnormal_cardiac_muscle1.46372173
47MP0003942_abnormal_urinary_system1.44953410
48MP0003718_maternal_effect1.43876716
49MP0002233_abnormal_nose_morphology1.42723498
50MP0008438_abnormal_cutaneous_collagen1.42486485
51MP0010352_gastrointestinal_tract_polyps1.42148194
52MP0002653_abnormal_ependyma_morphology1.37593734
53MP0002269_muscular_atrophy1.34572199
54MP0002084_abnormal_developmental_patter1.33076263
55MP0000598_abnormal_liver_morphology1.29089657
56MP0002928_abnormal_bile_duct1.27933811
57MP0001293_anophthalmia1.26391537
58MP0005395_other_phenotype1.20929794
59MP0001764_abnormal_homeostasis1.20303601
60MP0004264_abnormal_extraembryonic_tissu1.18666581
61MP0003656_abnormal_erythrocyte_physiolo1.18545003
62MP0005023_abnormal_wound_healing1.17691047
63MP0005410_abnormal_fertilization1.16447110
64MP0006054_spinal_hemorrhage1.15491840
65MP0005623_abnormal_meninges_morphology1.14258375
66MP0004019_abnormal_vitamin_homeostasis1.13446019
67MP0002078_abnormal_glucose_homeostasis1.12541046
68MP0009697_abnormal_copulation1.11854462
69MP0000049_abnormal_middle_ear1.11792111
70MP0005584_abnormal_enzyme/coenzyme_acti1.11298882
71MP0000762_abnormal_tongue_morphology1.09352531
72MP0008961_abnormal_basal_metabolism1.08826239
73MP0003300_gastrointestinal_ulcer1.07354981
74MP0003868_abnormal_feces_composition1.06803581
75MP0001929_abnormal_gametogenesis1.06220635
76MP0009703_decreased_birth_body1.06040831
77MP0008004_abnormal_stomach_pH1.05145975
78MP0003698_abnormal_male_reproductive1.04791738
79MP0003861_abnormal_nervous_system1.04482747
80MP0002234_abnormal_pharynx_morphology1.04372378
81MP0002085_abnormal_embryonic_tissue1.04244007
82MP0009643_abnormal_urine_homeostasis1.03373092
83MP0002138_abnormal_hepatobiliary_system0.99849481
84MP0005666_abnormal_adipose_tissue0.99505065
85MP0003755_abnormal_palate_morphology0.99245202
86MP0009384_cardiac_valve_regurgitation0.98680391
87MP0002116_abnormal_craniofacial_bone0.96989880
88MP0002277_abnormal_respiratory_mucosa0.96503849
89MP0002092_abnormal_eye_morphology0.96400270
90MP0003122_maternal_imprinting0.96130826
91MP0010307_abnormal_tumor_latency0.95115944
92MP0004233_abnormal_muscle_weight0.94232406
93MP0000428_abnormal_craniofacial_morphol0.94119819
94MP0000003_abnormal_adipose_tissue0.94088125
95MP0005380_embryogenesis_phenotype0.92688015
96MP0001672_abnormal_embryogenesis/_devel0.92688015
97MP0001299_abnormal_eye_distance/0.92475142
98MP0000537_abnormal_urethra_morphology0.92181830
99MP0003566_abnormal_cell_adhesion0.92041064
100MP0000747_muscle_weakness0.91412090
101MP0002697_abnormal_eye_size0.91096141
102MP0004782_abnormal_surfactant_physiolog0.90290306
103MP0004036_abnormal_muscle_relaxation0.89901997
104MP0003941_abnormal_skin_development0.87738495
105MP0006292_abnormal_olfactory_placode0.87433581
106MP0004957_abnormal_blastocyst_morpholog0.86993580
107MP0005220_abnormal_exocrine_pancreas0.86474601
108MP0003935_abnormal_craniofacial_develop0.84499884
109MP0000026_abnormal_inner_ear0.84455997
110MP0002332_abnormal_exercise_endurance0.84390725
111MP0001727_abnormal_embryo_implantation0.84331590
112MP0000579_abnormal_nail_morphology0.83409595
113MP0002638_abnormal_pupillary_reflex0.82944558
114MP0002734_abnormal_mechanical_nocicepti0.82454119
115MP0003091_abnormal_cell_migration0.81754004
116MP0005375_adipose_tissue_phenotype0.81441476
117MP0000534_abnormal_ureter_morphology0.80792315
118MP0002161_abnormal_fertility/fecundity0.80160814
119MP0000955_abnormal_spinal_cord0.79755570
120MP0000678_abnormal_parathyroid_gland0.78933240
121MP0003693_abnormal_embryo_hatching0.78509239
122MP0001286_abnormal_eye_development0.77331166
123MP0001756_abnormal_urination0.77100897
124MP0001485_abnormal_pinna_reflex0.76352017
125MP0003984_embryonic_growth_retardation0.76212919
126MP0000604_amyloidosis0.75325384
127MP0005448_abnormal_energy_balance0.73891642
128MP0003115_abnormal_respiratory_system0.73795893
129MP0003950_abnormal_plasma_membrane0.72593059
130MP0009642_abnormal_blood_homeostasis0.71886885
131MP0004197_abnormal_fetal_growth/weight/0.71823857
132MP0004085_abnormal_heartbeat0.71468644
133MP0003938_abnormal_ear_development0.71141122
134MP0009115_abnormal_fat_cell0.70344830
135MP0000778_abnormal_nervous_system0.70060475
136MP0000432_abnormal_head_morphology0.69416549
137MP0005391_vision/eye_phenotype0.69391934
138MP0000358_abnormal_cell_content/0.67437530
139MP0002971_abnormal_brown_adipose0.66811544
140MP0009053_abnormal_anal_canal0.66729653
141MP0003646_muscle_fatigue0.66341430
142MP0003279_aneurysm0.66314944
143MP0001765_abnormal_ion_homeostasis0.65490033
144MP0004087_abnormal_muscle_fiber0.65409939
145MP0002127_abnormal_cardiovascular_syste0.65362298
146MP0005266_abnormal_metabolism0.65153939
147MP0001944_abnormal_pancreas_morphology0.65148252
148MP0002970_abnormal_white_adipose0.64582220
149MP0009763_increased_sensitivity_to0.63429532
150MP0000467_abnormal_esophagus_morphology0.63376514
151MP0001188_hyperpigmentation0.62958063
152MP0003119_abnormal_digestive_system0.62875008
153MP0005334_abnormal_fat_pad0.61891285
154MP0005187_abnormal_penis_morphology0.61194183
155MP0002168_other_aberrant_phenotype0.60286192
156MP0005636_abnormal_mineral_homeostasis0.56970789
157MP0002160_abnormal_reproductive_system0.56606517
158MP0005076_abnormal_cell_differentiation0.56546182
159MP0002877_abnormal_melanocyte_morpholog0.55465512
160MP0005385_cardiovascular_system_phenoty0.53017914
161MP0001544_abnormal_cardiovascular_syste0.53017914
162MP0006036_abnormal_mitochondrial_physio0.52602851
163MP0003953_abnormal_hormone_level0.52524305
164MP0002896_abnormal_bone_mineralization0.52095935
165MP0003943_abnormal_hepatobiliary_system0.51202716
166MP0005376_homeostasis/metabolism_phenot0.51069055
167MP0010630_abnormal_cardiac_muscle0.50448939
168MP0003959_abnormal_lean_body0.50380954
169MP0006138_congestive_heart_failure0.50305128
170MP0008469_abnormal_protein_level0.49948376
171MP0002128_abnormal_blood_circulation0.48280892
172MP0002909_abnormal_adrenal_gland0.45839956
173MP0001243_abnormal_dermal_layer0.44863420
174MP0003890_abnormal_embryonic-extraembry0.44786943
175MP0003221_abnormal_cardiomyocyte_apopto0.43754831
176MP0008775_abnormal_heart_ventricle0.42885234
177MP0000759_abnormal_skeletal_muscle0.42659135
178MP0009672_abnormal_birth_weight0.42535951
179MP0002088_abnormal_embryonic_growth/wei0.42253896

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.88815687
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.88815687
3Bronchiectasis (HP:0002110)6.27292616
4Deep venous thrombosis (HP:0002625)5.32414836
5Intrahepatic cholestasis (HP:0001406)4.70906544
6Xanthomatosis (HP:0000991)4.33721773
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.25977992
8Hypobetalipoproteinemia (HP:0003563)4.16818097
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.07125469
10Complement deficiency (HP:0004431)3.65293893
11Ketosis (HP:0001946)3.52573841
12Prolonged partial thromboplastin time (HP:0003645)3.51253629
13Abnormality of the lower motor neuron (HP:0002366)3.47818470
14Male infertility (HP:0003251)3.37578005
15Hyperglycinuria (HP:0003108)3.36980561
16Abnormality of serine family amino acid metabolism (HP:0010894)3.36215430
17Abnormality of glycine metabolism (HP:0010895)3.36215430
18Hyperammonemia (HP:0001987)3.33417005
19Hypolipoproteinemia (HP:0010981)3.30940023
20Abnormality of the common coagulation pathway (HP:0010990)3.27885858
21Hyperglycinemia (HP:0002154)3.27341800
22Hypoglycemic coma (HP:0001325)3.25265355
23Pancreatic fibrosis (HP:0100732)3.22730242
24Abnormal respiratory motile cilium physiology (HP:0012261)3.21225785
25Back pain (HP:0003418)3.18676196
26Bronchitis (HP:0012387)3.16856626
27Hyperlipoproteinemia (HP:0010980)3.12961445
28Chronic sinusitis (HP:0011109)3.07599870
29Hypoalphalipoproteinemia (HP:0003233)3.03788681
30Atelectasis (HP:0100750)3.00192905
31True hermaphroditism (HP:0010459)2.96872558
32Recurrent sinusitis (HP:0011108)2.91822983
33Rhinitis (HP:0012384)2.91183093
34Spontaneous abortion (HP:0005268)2.88000351
35Recurrent otitis media (HP:0000403)2.86148430
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.85043495
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.84627169
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.84229718
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.82067865
40Abnormality of the intrinsic pathway (HP:0010989)2.77728131
41Ketoacidosis (HP:0001993)2.76824693
42Nephronophthisis (HP:0000090)2.74773589
43Spastic diplegia (HP:0001264)2.73625281
44Abnormal ciliary motility (HP:0012262)2.71869796
45Hypercholesterolemia (HP:0003124)2.66716611
46Mitral stenosis (HP:0001718)2.62932360
47Congenital primary aphakia (HP:0007707)2.61626790
48Medial flaring of the eyebrow (HP:0010747)2.61437279
49Epidermoid cyst (HP:0200040)2.60799673
50Abnormality of midbrain morphology (HP:0002418)2.59604102
51Molar tooth sign on MRI (HP:0002419)2.59604102
52Gait imbalance (HP:0002141)2.54124532
53Nasal polyposis (HP:0100582)2.51937156
54Cystic liver disease (HP:0006706)2.51064715
55Hyporeflexia of lower limbs (HP:0002600)2.50478425
56Abnormality of complement system (HP:0005339)2.50245411
57Gout (HP:0001997)2.49729605
58Tubulointerstitial nephritis (HP:0001970)2.48187139
59Abnormality of fatty-acid metabolism (HP:0004359)2.48149392
60Postaxial foot polydactyly (HP:0001830)2.42613138
61Chronic hepatic failure (HP:0100626)2.41998817
62Abnormal biliary tract physiology (HP:0012439)2.39323875
63Bile duct proliferation (HP:0001408)2.39323875
64Pancreatic cysts (HP:0001737)2.39211789
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.38049206
66Myocardial infarction (HP:0001658)2.36741918
67Poor coordination (HP:0002370)2.36317074
68Skin nodule (HP:0200036)2.35885825
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32638437
70Dicarboxylic aciduria (HP:0003215)2.32638437
71Bell-shaped thorax (HP:0001591)2.32294775
72Nephrogenic diabetes insipidus (HP:0009806)2.29329258
73Hyperbilirubinemia (HP:0002904)2.28183103
74Protrusio acetabuli (HP:0003179)2.27749916
75Hyperacusis (HP:0010780)2.26594835
76Abnormality of the nasal mucosa (HP:0000433)2.24588190
77Hyperactive renin-angiotensin system (HP:0000841)2.23452647
78Late onset (HP:0003584)2.22358846
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20924238
80Renovascular hypertension (HP:0100817)2.14914477
81Abnormality of the renal medulla (HP:0100957)2.14500628
82Hepatocellular carcinoma (HP:0001402)2.13299074
83Termporal pattern (HP:0011008)2.13231161
84Insidious onset (HP:0003587)2.13231161
85Abnormality of methionine metabolism (HP:0010901)2.13144770
86Neonatal onset (HP:0003623)2.13069032
87Fat malabsorption (HP:0002630)2.12489854
88Joint hemorrhage (HP:0005261)2.12361939
89Abnormality of purine metabolism (HP:0004352)2.11804628
90Abnormality of nucleobase metabolism (HP:0010932)2.11460635
91Polygenic inheritance (HP:0010982)2.10791863
92Abnormality of pyrimidine metabolism (HP:0004353)2.10772648
93Chronic bronchitis (HP:0004469)2.09916126
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.09684982
95Tubular atrophy (HP:0000092)2.08859141
96Increased CSF protein (HP:0002922)2.08381938
97Hypoglycemic seizures (HP:0002173)2.08349693
98Hand muscle atrophy (HP:0009130)2.07683372
99Myoglobinuria (HP:0002913)2.06382383
100Hyperinsulinemic hypoglycemia (HP:0000825)2.05329419
101Anencephaly (HP:0002323)2.03766772
102Vaginal atresia (HP:0000148)1.99494811
103Abnormal delivery (HP:0001787)1.99134780
104Genital tract atresia (HP:0001827)1.98485979
105Metabolic acidosis (HP:0001942)1.96686687
106Sensorimotor neuropathy (HP:0007141)1.95332384
107Rhabdomyolysis (HP:0003201)1.94752547
108Hyperglycemia (HP:0003074)1.94170385
109Distal upper limb amyotrophy (HP:0007149)1.93217019
110Upper limb amyotrophy (HP:0009129)1.93217019
111Abnormal respiratory epithelium morphology (HP:0012253)1.91700883
112Abnormal respiratory motile cilium morphology (HP:0005938)1.91700883
113Conjugated hyperbilirubinemia (HP:0002908)1.91623790
114Abnormality of serum amino acid levels (HP:0003112)1.88180472
115Peritonitis (HP:0002586)1.87102327
116Elfin facies (HP:0004428)1.85153916
117Cholelithiasis (HP:0001081)1.84267510
118Infertility (HP:0000789)1.83727373
119Abnormality of proline metabolism (HP:0010907)1.82957552
120Hydroxyprolinuria (HP:0003080)1.82957552
121Congenital hepatic fibrosis (HP:0002612)1.81597888
122Abnormal gallbladder morphology (HP:0012437)1.81186350
123Stroke (HP:0001297)1.79899136
124Postaxial hand polydactyly (HP:0001162)1.79335660
125Polycythemia (HP:0001901)1.79299361
126Abnormality of the dental root (HP:0006486)1.79126784
127Taurodontia (HP:0000679)1.79126784
128Abnormality of permanent molar morphology (HP:0011071)1.79126784
129Occipital encephalocele (HP:0002085)1.78975847
130Exercise-induced myalgia (HP:0003738)1.77005303
131Upper motor neuron abnormality (HP:0002127)1.74776767
132Status epilepticus (HP:0002133)1.72219739
133Long toe (HP:0010511)1.71890751
134Chronic otitis media (HP:0000389)1.70807761
135Oculomotor apraxia (HP:0000657)1.69134588
136Striae distensae (HP:0001065)1.68715287
137Abnormal cartilage morphology (HP:0002763)1.67893768
138Sclerocornea (HP:0000647)1.67888647
139Bowel diverticulosis (HP:0005222)1.67739756
140Abnormality of dentin (HP:0010299)1.65635298
141Absent frontal sinuses (HP:0002688)1.65423855
142Bifid scrotum (HP:0000048)1.63944680
143Preaxial hand polydactyly (HP:0001177)1.61818836
144Abnormality of molar (HP:0011077)1.61701619
145Abnormality of molar morphology (HP:0011070)1.61701619
146Abnormality of the dental pulp (HP:0006479)1.60346221
147Male pseudohermaphroditism (HP:0000037)1.56730923
148Supernumerary spleens (HP:0009799)1.52786966
149Median cleft lip (HP:0000161)1.52337696
150Aplasia/Hypoplasia of the lens (HP:0008063)1.51665874
151Decreased circulating renin level (HP:0003351)1.51587342
152Short nail (HP:0001799)1.49431677
153Abnormality of abdominal situs (HP:0011620)1.47218282
154Abdominal situs inversus (HP:0003363)1.47218282
155Hyperkalemia (HP:0002153)1.46606073
156Stage 5 chronic kidney disease (HP:0003774)1.40736686
157Furrowed tongue (HP:0000221)1.39001147
158Abnormality of the distal phalanges of the toes (HP:0010182)1.38832253
159Facial cleft (HP:0002006)1.38618594
160Tubulointerstitial abnormality (HP:0001969)1.36375198
161Broad foot (HP:0001769)1.35147118
162Renal dysplasia (HP:0000110)1.34619465
163Aplasia/Hypoplasia of the sacrum (HP:0008517)1.30445115
164Abnormality of the aortic arch (HP:0012303)1.25316394
165Obstructive sleep apnea (HP:0002870)1.25136372
166Transposition of the great arteries (HP:0001669)1.24083783
167Abnormal connection of the cardiac segments (HP:0011545)1.24083783
168Abnormal ventriculo-arterial connection (HP:0011563)1.24083783
169Hyperaldosteronism (HP:0000859)1.22324777
170Renal salt wasting (HP:0000127)1.21991880
171Polycystic kidney dysplasia (HP:0000113)1.21925706
172Short thorax (HP:0010306)1.21794122
173Hip dysplasia (HP:0001385)1.21243533
174Osteomalacia (HP:0002749)1.18797046
175Cone-rod dystrophy (HP:0000548)1.18405388
176Nephropathy (HP:0000112)1.18338280
177Asplenia (HP:0001746)1.18251910
178Sleep apnea (HP:0010535)1.17418323
179Aplasia/Hypoplasia of the spleen (HP:0010451)1.16749662
180Prominent nasal bridge (HP:0000426)1.15682525
181Hyponatremia (HP:0002902)1.15427005
182Dental crowding (HP:0000678)1.14951386
183Left ventricular hypertrophy (HP:0001712)1.14281924
184Polydipsia (HP:0001959)1.13820426
185Abnormal drinking behavior (HP:0030082)1.13820426
186Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.12196751
187Papillary thyroid carcinoma (HP:0002895)1.12071141
188Arterial tortuosity (HP:0005116)1.11280545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.96512890
2PDK33.96488483
3PDK43.96488483
4PLK43.64869590
5EEF2K3.40791482
6MAP3K103.01198648
7PKN22.96081031
8PNCK2.89100027
9ERN12.71233231
10MST42.68024457
11BCKDK2.67033757
12NEK12.65825835
13TTK2.34307837
14BRSK22.26791362
15TTN2.25504860
16EPHA22.25479092
17PDK22.23935136
18SIK12.00146666
19FLT31.97007501
20STK38L1.80038219
21CAMK1G1.79844910
22BRD41.76156439
23FGFR41.71081615
24TNIK1.65027100
25BCR1.64479910
26MAPKAPK31.57268592
27STK241.53053886
28PTK61.50229138
29CAMKK21.38213778
30BRSK11.37492643
31MAP2K31.33133102
32MET1.29641628
33RIPK11.28305145
34EIF2AK11.26120093
35SRPK11.26033094
36MST1R1.24833891
37PDGFRA1.23051903
38DYRK31.22645828
39CAMKK11.19599499
40LATS11.19382631
41SMG11.18072627
42PBK1.17738449
43NME11.13885778
44NEK91.13134244
45TRIM281.12318477
46CCNB11.09744890
47MKNK21.07154578
48ERBB31.07040451
49MAP3K20.96921730
50NEK60.95115321
51TESK10.94340343
52CAMK1D0.92794091
53LMTK20.91894693
54MTOR0.89126048
55TAOK10.88574765
56PAK30.87776652
57MAPK150.87689797
58TSSK60.87553677
59MAPK110.87542491
60CDK120.85240508
61MAP2K40.83990737
62PRKCH0.82979589
63CDK80.82074318
64PIK3CG0.81340265
65MARK20.79510255
66IRAK30.79457981
67TGFBR20.78719266
68SCYL20.78391471
69TAOK20.77180655
70AURKA0.76558316
71LRRK20.76054911
72ITK0.76009877
73SGK30.75670894
74MAP3K110.74487322
75WEE10.73628063
76STK390.73017371
77MAP3K70.72944824
78RET0.72122304
79CDC70.71777857
80WNK30.71753987
81PLK10.70199238
82MKNK10.69618558
83FGFR10.69377898
84PTK20.69279051
85TRPM70.68747567
86STK30.68643666
87ZAP700.68309170
88CHUK0.68047976
89ERBB40.67779707
90TYK20.67401685
91PRKAA10.66395269
92KSR10.65472633
93MAP3K90.65410827
94IRAK10.65406233
95LATS20.65155492
96JAK20.64605559
97SGK4940.64054813
98SGK2230.64054813
99MAP3K40.63773265
100STK160.63507875
101STK100.62014673
102CASK0.61357386
103AKT20.60050957
104TBK10.59175028
105JAK10.59028973
106WNK10.58861949
107CSNK1E0.58837874
108CDC42BPA0.55760247
109EPHB10.55467056
110PRKAA20.55305710
111CDK70.55013139
112KDR0.54483254
113STK380.54309866
114FRK0.53793119
115MAP2K60.53463062
116CHEK20.51724338
117FGFR30.51034604
118PTK2B0.50424867
119RPS6KB20.50301591
120NTRK10.49083236
121ARAF0.48346799
122ICK0.48141614
123CHEK10.48129945
124MAPK120.47659464
125PAK40.47303371
126KSR20.46175043
127AKT30.46055116
128MELK0.45852889
129DYRK1B0.44679107
130CDK90.43649631
131NEK20.43214413
132MAP2K10.42773773
133PRKD30.42771006
134FER0.41835435
135TGFBR10.41826972
136CDK60.41536780
137NLK0.41206900
138PDGFRB0.40654889
139PDK10.40591682
140CDK20.39404257
141GRK10.39165942
142ERBB20.39068824
143PRKACG0.38608541
144PLK20.37942540
145MAP4K10.36963051
146DMPK0.36945931
147INSRR0.36753661
148EPHB20.36717549
149CAMK40.36662200
150CDK10.35192593
151JAK30.34352585
152PAK20.33353562
153SGK20.32813215
154GRK60.32699406
155DDR20.32510394

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.20539656
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.91534214
3Nitrogen metabolism_Homo sapiens_hsa009103.39724498
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.04607598
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99071679
6Arginine biosynthesis_Homo sapiens_hsa002202.93131021
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.82918984
8Fatty acid degradation_Homo sapiens_hsa000712.65168770
9Propanoate metabolism_Homo sapiens_hsa006402.51960491
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49547850
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39985997
12Tryptophan metabolism_Homo sapiens_hsa003802.39702441
13Complement and coagulation cascades_Homo sapiens_hsa046102.18425803
14Huntingtons disease_Homo sapiens_hsa050162.18231486
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17864428
16Carbon metabolism_Homo sapiens_hsa012002.01319066
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.99699831
18Circadian rhythm_Homo sapiens_hsa047101.98998598
19Butanoate metabolism_Homo sapiens_hsa006501.98441301
20Fatty acid metabolism_Homo sapiens_hsa012121.98008099
21Pyruvate metabolism_Homo sapiens_hsa006201.96332576
22PPAR signaling pathway_Homo sapiens_hsa033201.93825847
23Biosynthesis of amino acids_Homo sapiens_hsa012301.93288414
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87691963
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85393458
26Adherens junction_Homo sapiens_hsa045201.81329637
27Selenocompound metabolism_Homo sapiens_hsa004501.78769753
28Basal cell carcinoma_Homo sapiens_hsa052171.61886390
29Hedgehog signaling pathway_Homo sapiens_hsa043401.58540460
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.55229759
31Hippo signaling pathway_Homo sapiens_hsa043901.49320247
32Caffeine metabolism_Homo sapiens_hsa002321.40906830
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.38242560
34mRNA surveillance pathway_Homo sapiens_hsa030151.37573195
35Peroxisome_Homo sapiens_hsa041461.37285582
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35931080
37Tight junction_Homo sapiens_hsa045301.33126407
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28978745
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23263303
40Notch signaling pathway_Homo sapiens_hsa043301.18681628
41Bile secretion_Homo sapiens_hsa049761.18458019
42Starch and sucrose metabolism_Homo sapiens_hsa005001.17569355
43Phenylalanine metabolism_Homo sapiens_hsa003601.17447456
44Staphylococcus aureus infection_Homo sapiens_hsa051501.16657221
45beta-Alanine metabolism_Homo sapiens_hsa004101.16483789
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09428361
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09312218
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08063827
49Lysine degradation_Homo sapiens_hsa003101.04988366
50Chemical carcinogenesis_Homo sapiens_hsa052041.01654196
51Pentose phosphate pathway_Homo sapiens_hsa000301.00358819
52ABC transporters_Homo sapiens_hsa020100.99301874
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98951719
54Sphingolipid metabolism_Homo sapiens_hsa006000.97140486
55TGF-beta signaling pathway_Homo sapiens_hsa043500.96872128
56Sulfur relay system_Homo sapiens_hsa041220.96633531
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96289114
58Cocaine addiction_Homo sapiens_hsa050300.96050416
59RNA transport_Homo sapiens_hsa030130.95588555
60Nucleotide excision repair_Homo sapiens_hsa034200.93427986
61Vitamin B6 metabolism_Homo sapiens_hsa007500.91391793
62Fat digestion and absorption_Homo sapiens_hsa049750.89130925
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88203713
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87508616
65Wnt signaling pathway_Homo sapiens_hsa043100.87143210
66Prostate cancer_Homo sapiens_hsa052150.85500413
67Tyrosine metabolism_Homo sapiens_hsa003500.81965076
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81854137
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.80552673
70Insulin resistance_Homo sapiens_hsa049310.79081523
71Glucagon signaling pathway_Homo sapiens_hsa049220.78009111
72Sulfur metabolism_Homo sapiens_hsa009200.73765281
73Dorso-ventral axis formation_Homo sapiens_hsa043200.68863650
74Retinol metabolism_Homo sapiens_hsa008300.67951792
75Cell cycle_Homo sapiens_hsa041100.67461321
76Glycerolipid metabolism_Homo sapiens_hsa005610.67187208
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.66699382
78Spliceosome_Homo sapiens_hsa030400.65827413
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.65121345
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63214162
81Fatty acid biosynthesis_Homo sapiens_hsa000610.63170078
82One carbon pool by folate_Homo sapiens_hsa006700.62446230
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.61255803
84Melanogenesis_Homo sapiens_hsa049160.60983019
85Histidine metabolism_Homo sapiens_hsa003400.60764931
86Olfactory transduction_Homo sapiens_hsa047400.60619853
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58848251
88cAMP signaling pathway_Homo sapiens_hsa040240.58447589
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58075256
90Basal transcription factors_Homo sapiens_hsa030220.57864332
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.56216048
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56041949
93Insulin signaling pathway_Homo sapiens_hsa049100.55040323
94Oocyte meiosis_Homo sapiens_hsa041140.53707915
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53510020
96MicroRNAs in cancer_Homo sapiens_hsa052060.52566802
97Fructose and mannose metabolism_Homo sapiens_hsa000510.50470321
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50314354
99Choline metabolism in cancer_Homo sapiens_hsa052310.50164173
100AMPK signaling pathway_Homo sapiens_hsa041520.46634554
101Arginine and proline metabolism_Homo sapiens_hsa003300.46294820
102Thyroid cancer_Homo sapiens_hsa052160.44487225
103mTOR signaling pathway_Homo sapiens_hsa041500.42754711
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42298975
105Thyroid hormone synthesis_Homo sapiens_hsa049180.40745039
106Axon guidance_Homo sapiens_hsa043600.40530133
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39670981
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38815983
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38778934
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38032680
111Dilated cardiomyopathy_Homo sapiens_hsa054140.37568672
112Purine metabolism_Homo sapiens_hsa002300.36932279
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36641892
114ECM-receptor interaction_Homo sapiens_hsa045120.36208613
115Colorectal cancer_Homo sapiens_hsa052100.35248607
116Type II diabetes mellitus_Homo sapiens_hsa049300.32614302
117Prolactin signaling pathway_Homo sapiens_hsa049170.32192622
118Folate biosynthesis_Homo sapiens_hsa007900.30613101
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28795295
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24277647
121Galactose metabolism_Homo sapiens_hsa000520.23313401
122Prion diseases_Homo sapiens_hsa050200.22472840
123Fatty acid elongation_Homo sapiens_hsa000620.22458035
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21181195
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19988865
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19440797
127Chronic myeloid leukemia_Homo sapiens_hsa052200.19418011
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15678494
129Proteoglycans in cancer_Homo sapiens_hsa052050.15196147
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15110187
131Glutathione metabolism_Homo sapiens_hsa004800.14063179
132Steroid biosynthesis_Homo sapiens_hsa001000.12277759
133Bladder cancer_Homo sapiens_hsa052190.12249365
134Focal adhesion_Homo sapiens_hsa045100.11527697
135Metabolic pathways_Homo sapiens_hsa011000.11227243
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.10520064
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.09915707
138FoxO signaling pathway_Homo sapiens_hsa040680.08769415
139Endometrial cancer_Homo sapiens_hsa052130.08469062
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05963060
141Systemic lupus erythematosus_Homo sapiens_hsa053220.05838770
142Amoebiasis_Homo sapiens_hsa051460.05113026
143Vitamin digestion and absorption_Homo sapiens_hsa049770.04117551
144Legionellosis_Homo sapiens_hsa051340.03689611

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