CYB561

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)7.43542758
2axonemal dynein complex assembly (GO:0070286)7.24924074
3desmosome organization (GO:0002934)5.95732244
4motile cilium assembly (GO:0044458)5.59112880
5cilium or flagellum-dependent cell motility (GO:0001539)5.26802416
6behavioral response to nicotine (GO:0035095)5.20495837
7ear development (GO:0043583)5.10563964
8sympathetic nervous system development (GO:0048485)4.90887581
9cilium movement (GO:0003341)4.69541260
10primary alcohol catabolic process (GO:0034310)4.68162345
11vitamin transmembrane transport (GO:0035461)4.53864048
12intestinal epithelial cell development (GO:0060576)4.50658887
13regulation of water loss via skin (GO:0033561)4.49131113
14multicellular organismal water homeostasis (GO:0050891)4.37029694
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31392419
16behavioral response to ethanol (GO:0048149)4.26479039
17protein retention in ER lumen (GO:0006621)4.19502859
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.19286996
19norepinephrine metabolic process (GO:0042415)4.11056779
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.10429423
21positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.10078598
22neurotransmitter catabolic process (GO:0042135)4.08457909
23establishment of apical/basal cell polarity (GO:0035089)4.06331460
24retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.03819439
25positive regulation of Cdc42 GTPase activity (GO:0043089)4.03676557
26amyloid precursor protein catabolic process (GO:0042987)4.00877641
27phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.96070423
28catecholamine biosynthetic process (GO:0042423)3.95745139
29catechol-containing compound biosynthetic process (GO:0009713)3.95745139
30synaptic vesicle exocytosis (GO:0016079)3.93563831
31calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.93474980
32proline biosynthetic process (GO:0006561)3.82855682
33dopamine metabolic process (GO:0042417)3.82376892
34positive regulation of keratinocyte differentiation (GO:0045618)3.78855893
35catecholamine transport (GO:0051937)3.78163999
36regulation of synaptic vesicle exocytosis (GO:2000300)3.76860788
37dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.68256611
38regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.63783285
39proline transport (GO:0015824)3.63334927
40maternal placenta development (GO:0001893)3.61005432
41establishment of skin barrier (GO:0061436)3.60902181
42water homeostasis (GO:0030104)3.57824460
43neurotransmitter secretion (GO:0007269)3.57765018
44glutamate secretion (GO:0014047)3.53915984
45negative regulation of microtubule polymerization (GO:0031115)3.51458595
46branching involved in mammary gland duct morphogenesis (GO:0060444)3.51360877
47mating behavior (GO:0007617)3.50690291
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.47754566
49diterpenoid biosynthetic process (GO:0016102)3.45688323
50positive regulation of epidermal cell differentiation (GO:0045606)3.44472035
51activation of protein kinase A activity (GO:0034199)3.43653027
52synaptic vesicle maturation (GO:0016188)3.39236525
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39071287
54epithelial cilium movement (GO:0003351)3.37529452
55ATP hydrolysis coupled proton transport (GO:0015991)3.36599875
56energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.36599875
57dopamine biosynthetic process (GO:0042416)3.35646812
58semaphorin-plexin signaling pathway (GO:0071526)3.35444467
59lung epithelium development (GO:0060428)3.34298557
60bundle of His cell to Purkinje myocyte communication (GO:0086069)3.34241792
61epithelial cell-cell adhesion (GO:0090136)3.32579360
62regulation of interleukin-13 production (GO:0032656)3.31857734
63negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.28529254
64negative regulation of cell size (GO:0045792)3.27802933
65ethanol metabolic process (GO:0006067)3.27292007
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24111066
67iron ion import (GO:0097286)3.23559959
68regulation of synaptic vesicle transport (GO:1902803)3.21238713
69adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.20028147
70synaptic transmission, cholinergic (GO:0007271)3.19987843
71response to parathyroid hormone (GO:0071107)3.19343512
72establishment of monopolar cell polarity (GO:0061162)3.16878689
73establishment or maintenance of monopolar cell polarity (GO:0061339)3.16878689
74cell migration in hindbrain (GO:0021535)3.16359994
75left/right pattern formation (GO:0060972)3.16205707
76tight junction assembly (GO:0070830)3.15869680
77surfactant homeostasis (GO:0043129)3.14492797
78regulation of vesicle fusion (GO:0031338)3.13992216
79neurotransmitter biosynthetic process (GO:0042136)3.12031883
80positive regulation of vesicle fusion (GO:0031340)3.11098082
81GDP-mannose metabolic process (GO:0019673)3.10415166
82regulation of autophagic vacuole assembly (GO:2000785)3.10002803
83epithelial cell differentiation involved in prostate gland development (GO:0060742)3.08258111
84neuromuscular synaptic transmission (GO:0007274)3.08118099
85amyloid precursor protein metabolic process (GO:0042982)3.07976405
86biotin metabolic process (GO:0006768)3.07907819
87vocalization behavior (GO:0071625)3.07864117
88regulation of calcium ion-dependent exocytosis (GO:0017158)3.05977995
89epithelial cell maturation (GO:0002070)3.04931642
90peptidyl-tyrosine autophosphorylation (GO:0038083)3.04280692
91Golgi transport vesicle coating (GO:0048200)3.03550266
92COPI coating of Golgi vesicle (GO:0048205)3.03550266
93neurotransmitter transport (GO:0006836)3.03415406
94positive regulation of neurotransmitter transport (GO:0051590)3.03238567
95toxin metabolic process (GO:0009404)3.02357578
96catecholamine metabolic process (GO:0006584)3.01714079
97catechol-containing compound metabolic process (GO:0009712)3.01714079
98regulation of interleukin-5 production (GO:0032674)3.01576466
99endothelial cell chemotaxis (GO:0035767)3.00745201
100cytoskeletal anchoring at plasma membrane (GO:0007016)3.00475100
101maternal behavior (GO:0042711)2.98477728
102apical protein localization (GO:0045176)2.97447198
103detection of calcium ion (GO:0005513)2.96677556
104pyrimidine-containing compound transmembrane transport (GO:0072531)2.96477646
105glutathione biosynthetic process (GO:0006750)2.94558031
106transferrin transport (GO:0033572)2.94346675
107regulation of neurotransmitter secretion (GO:0046928)2.93412719
108ER overload response (GO:0006983)2.92773687
109response to food (GO:0032094)2.89986842
110regulation of fatty acid beta-oxidation (GO:0031998)2.89506832
111endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.88967436
112regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.88878334
113regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.88878334
114regulation of neurotransmitter transport (GO:0051588)2.87528096
115primary amino compound metabolic process (GO:1901160)2.87040040
116activation of Rac GTPase activity (GO:0032863)2.86682205
117regulation of keratinocyte differentiation (GO:0045616)2.84818681
118dopamine receptor signaling pathway (GO:0007212)2.79855092
119cellular response to nicotine (GO:0071316)2.79853114
120trivalent inorganic cation transport (GO:0072512)2.79336704
121ferric iron transport (GO:0015682)2.79336704
122striated muscle atrophy (GO:0014891)2.77943287
123alkaloid metabolic process (GO:0009820)2.76039885
124neuron cell-cell adhesion (GO:0007158)2.75404980
125multi-organism reproductive behavior (GO:0044705)2.74594168
126response to water (GO:0009415)2.73967592
127response to amphetamine (GO:0001975)2.73915334
128reproductive behavior (GO:0019098)2.71996578
129asymmetric protein localization (GO:0008105)2.71912282
130membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71626216
131regulation of neurotransmitter levels (GO:0001505)2.71258309
132calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71202443
133protein maturation by protein folding (GO:0022417)2.70568798
134regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.69522003
135hepatocyte apoptotic process (GO:0097284)2.68264593
136ganglion development (GO:0061548)2.67863481
137proline metabolic process (GO:0006560)2.67098733
138regulation of respiratory gaseous exchange (GO:0043576)2.66569350
139neuromuscular process controlling posture (GO:0050884)2.64473310
140mammary gland epithelial cell differentiation (GO:0060644)2.64390043
141G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.64289314
142response to pain (GO:0048265)2.64019413
143cellular response to glucagon stimulus (GO:0071377)2.63127536
144NADH metabolic process (GO:0006734)2.62554365
145regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.62292991
146chemical homeostasis within a tissue (GO:0048875)2.61885302
147nitric oxide biosynthetic process (GO:0006809)2.61839230
148negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61712958
149diol metabolic process (GO:0034311)2.61660195
150regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61127355
151positive regulation of potassium ion transmembrane transport (GO:1901381)2.61089832
152cell differentiation involved in embryonic placenta development (GO:0060706)2.60752834
153regulation of clathrin-mediated endocytosis (GO:2000369)2.60666465
154glucose catabolic process (GO:0006007)2.60488850
155glucose 6-phosphate metabolic process (GO:0051156)2.60330622
156neuronal action potential propagation (GO:0019227)2.59737097
157protein localization to synapse (GO:0035418)2.59175912
158axoneme assembly (GO:0035082)2.58510660
159regulation of synaptic transmission, dopaminergic (GO:0032225)2.57742309
160cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.56941350
161sensory perception of smell (GO:0007608)2.56169700
162regulation of cell proliferation involved in kidney development (GO:1901722)2.56152903
163regulation of cholesterol biosynthetic process (GO:0045540)2.56137042
164nonribosomal peptide biosynthetic process (GO:0019184)2.55185704
165regulation of vacuole organization (GO:0044088)2.54694875
166monoamine transport (GO:0015844)2.54688498
167O-glycan processing (GO:0016266)2.54413273
168serotonin metabolic process (GO:0042428)2.53762727
169regulation of glutamate receptor signaling pathway (GO:1900449)2.51991936
170positive regulation of exocytosis (GO:0045921)2.51364888
171ventricular system development (GO:0021591)2.50571532
172regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.50174466
173parental behavior (GO:0060746)2.48978841
174dopaminergic neuron differentiation (GO:0071542)2.48505880
175pentose-phosphate shunt (GO:0006098)2.47803689
176negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.47316276
177positive regulation of cellular amine metabolic process (GO:0033240)2.47070998
178cell communication involved in cardiac conduction (GO:0086065)2.46955284
179skeletal muscle adaptation (GO:0043501)2.46691619
180regulation of exocytosis (GO:0017157)2.46670846
181cell-cell junction assembly (GO:0007043)2.46448051
182membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.46323279
183cellular copper ion homeostasis (GO:0006878)2.45851676
184response to nerve growth factor (GO:1990089)2.45132232
185cellular response to nerve growth factor stimulus (GO:1990090)2.45132232
186membrane repolarization during action potential (GO:0086011)2.44198093
187regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41934943
188positive regulation of epidermis development (GO:0045684)2.41861539
189locomotory exploration behavior (GO:0035641)2.41278367
190hemidesmosome assembly (GO:0031581)2.40552830
191columnar/cuboidal epithelial cell development (GO:0002066)2.40370947
192regulation of synapse structural plasticity (GO:0051823)2.40314724
193planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39571993
194regulation of heart rate by cardiac conduction (GO:0086091)2.39340132
195signal release (GO:0023061)2.38682816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.28869621
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.23002136
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.88958782
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35417397
5RACK7_27058665_Chip-Seq_MCF-7_Human3.22588099
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99070459
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83183429
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78917258
9* ZNF263_19887448_ChIP-Seq_K562_Human2.57657768
10* RUNX1_27514584_Chip-Seq_MCF-7_Human2.57124986
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43849451
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41789763
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40610564
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40157272
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35883180
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32335322
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32335322
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.30212471
19* LXR_22292898_ChIP-Seq_THP-1_Human2.27917519
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27441598
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21854867
22* NR3C1_23031785_ChIP-Seq_PC12_Mouse2.20352941
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.16117254
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13637657
25REST_21632747_ChIP-Seq_MESCs_Mouse2.12708943
26GBX2_23144817_ChIP-Seq_PC3_Human2.11040543
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.05358118
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.05035843
29* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.96410665
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.94594985
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.94399682
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.91005267
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85842850
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.83176121
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81596598
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79189394
37GATA3_24758297_ChIP-Seq_MCF-7_Human1.78977000
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76298711
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.76019958
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.74040821
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70677935
42SMC4_20622854_ChIP-Seq_HELA_Human1.69984765
43TAF15_26573619_Chip-Seq_HEK293_Human1.67523856
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65331350
45CREB1_26743006_Chip-Seq_LNCaP_Human1.64058447
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63724580
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63625318
48DROSHA_22980978_ChIP-Seq_HELA_Human1.63320971
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.62434881
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59817891
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59413961
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.59399092
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59067598
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.56223101
55P68_20966046_ChIP-Seq_HELA_Human1.56075734
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.51876899
57ATF3_27146783_Chip-Seq_COLON_Human1.50092147
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.47688267
59GATA6_25053715_ChIP-Seq_YYC3_Human1.45833578
60CLOCK_20551151_ChIP-Seq_293T_Human1.44758159
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43718404
62* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43398055
63* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43140358
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41653124
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40943902
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40643689
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.39968725
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38941772
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38872851
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38702534
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38616134
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35363961
73* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34449710
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.34408674
75SMAD4_21799915_ChIP-Seq_A2780_Human1.34216293
76* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33760249
77KLF5_25053715_ChIP-Seq_YYC3_Human1.33036919
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32935065
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.32445377
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32376198
81AR_21572438_ChIP-Seq_LNCaP_Human1.32345652
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32267011
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32232192
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.31883847
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31632871
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30638599
87BCAT_22108803_ChIP-Seq_LS180_Human1.30336348
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28323752
89CHD1_26751641_Chip-Seq_LNCaP_Human1.25943839
90* TCF7_22412390_ChIP-Seq_EML_Mouse1.24790993
91ZNF274_21170338_ChIP-Seq_K562_Hela1.24413966
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23878667
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23747961
94ELF5_23300383_ChIP-Seq_T47D_Human1.22683151
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22056719
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.19877117
97VDR_21846776_ChIP-Seq_THP-1_Human1.19265620
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18670275
99* TP63_22573176_ChIP-Seq_HFKS_Human1.17241108
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17062955
101GATA1_22025678_ChIP-Seq_K562_Human1.16098886
102RXR_22158963_ChIP-Seq_LIVER_Mouse1.15104527
103AHR_22903824_ChIP-Seq_MCF-7_Human1.14960420
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14239026
105AR_25329375_ChIP-Seq_VCAP_Human1.12591151
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.12043840
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.11793819
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11638401
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11052582
110* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09216882
111* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08037622
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07987943
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07472804
114* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06896116
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06848316
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06445317
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05879391
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05879391
119ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05456342
120KDM2B_26808549_Chip-Seq_DND41_Human1.04961490
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04949052
122TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04282183
123RARB_24833708_ChIP-Seq_LIVER_Mouse1.04150034
124* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03350797
125WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03203085
126SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02554438
127* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02132242
128* KDM2B_26808549_Chip-Seq_K562_Human1.01072612
129P300_19829295_ChIP-Seq_ESCs_Human1.01032385
130ARNT_22903824_ChIP-Seq_MCF-7_Human1.01002052
131AR_21909140_ChIP-Seq_LNCAP_Human1.00983611
132SMAD4_21741376_ChIP-Seq_HESCs_Human1.00966541
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00067841
134* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98833478
135SOX2_20726797_ChIP-Seq_SW620_Human0.98384610
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98367568
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98141305
138* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97400319
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97184832
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.97164733
141* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97013903
142BCOR_27268052_Chip-Seq_Bcells_Human0.95527026
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95049752
144CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94677132
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93301680
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93084363
147PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93063909
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93026675
149CTCF_27219007_Chip-Seq_Bcells_Human0.92428110
150* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91662975
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91527578
152RUNX2_22187159_ChIP-Seq_PCA_Human0.91426340
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91412029
154FOXO3_23340844_ChIP-Seq_DLD1_Human0.90954664
155ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90757380
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90264278
157SMAD3_21741376_ChIP-Seq_EPCs_Human0.89770842
158* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87305744
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.87099910
160ESR1_20079471_ChIP-ChIP_T-47D_Human0.87049638
161ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85982658
162OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85903616
163YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85572067
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84645994
165AR_19668381_ChIP-Seq_PC3_Human0.84488128
166GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83797525
167BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82915766
168RNF2_27304074_Chip-Seq_NSC_Mouse0.81992399
169CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81958746
170STAT3_23295773_ChIP-Seq_U87_Human0.81844791
171* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80250152
172SMAD3_21741376_ChIP-Seq_HESCs_Human0.80143528
173VDR_22108803_ChIP-Seq_LS180_Human0.80051089
174RING1B_27294783_Chip-Seq_NPCs_Mouse0.77863874
175SMAD3_21741376_ChIP-Seq_ESCs_Human0.77802249
176PRDM14_20953172_ChIP-Seq_ESCs_Human0.76784676
177NR3C1_21868756_ChIP-Seq_MCF10A_Human0.76392183
178UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76279775
179STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75660107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.91125034
2MP0010386_abnormal_urinary_bladder4.41207373
3MP0002796_impaired_skin_barrier3.74898458
4MP0003705_abnormal_hypodermis_morpholog3.22910682
5MP0004270_analgesia3.20871354
6MP0002638_abnormal_pupillary_reflex3.11517304
7MP0004859_abnormal_synaptic_plasticity3.04211391
8MP0010678_abnormal_skin_adnexa2.85761114
9MP0002909_abnormal_adrenal_gland2.83271109
10MP0000383_abnormal_hair_follicle2.64839183
11MP0003635_abnormal_synaptic_transmissio2.55542889
12MP0002098_abnormal_vibrissa_morphology2.52323184
13MP0004858_abnormal_nervous_system2.42038513
14MP0002734_abnormal_mechanical_nocicepti2.41733326
15MP0009745_abnormal_behavioral_response2.39834026
16MP0009780_abnormal_chondrocyte_physiolo2.36622835
17MP0010234_abnormal_vibrissa_follicle2.30585499
18MP0005501_abnormal_skin_physiology2.28356008
19MP0006276_abnormal_autonomic_nervous2.24411006
20MP0001440_abnormal_grooming_behavior2.21049429
21MP0005409_darkened_coat_color2.20346574
22MP0005083_abnormal_biliary_tract2.19419841
23MP0000538_abnormal_urinary_bladder2.18965305
24MP0002733_abnormal_thermal_nociception2.13839136
25MP0008875_abnormal_xenobiotic_pharmacok2.07336361
26MP0001970_abnormal_pain_threshold2.03657713
27MP0004782_abnormal_surfactant_physiolog2.03622871
28MP0000579_abnormal_nail_morphology2.00104695
29MP0002064_seizures1.97945345
30MP0000566_synostosis1.97553204
31MP0005645_abnormal_hypothalamus_physiol1.97525517
32MP0002572_abnormal_emotion/affect_behav1.97266188
33MP0002063_abnormal_learning/memory/cond1.96434115
34MP0003122_maternal_imprinting1.95124201
35MP0001501_abnormal_sleep_pattern1.93462588
36MP0000678_abnormal_parathyroid_gland1.91137395
37MP0001905_abnormal_dopamine_level1.87846944
38MP0005076_abnormal_cell_differentiation1.84768068
39MP0001968_abnormal_touch/_nociception1.81727539
40MP0003191_abnormal_cellular_cholesterol1.70974429
41MP0005058_abnormal_lysosome_morphology1.69088407
42MP0005451_abnormal_body_composition1.69000068
43MP0003787_abnormal_imprinting1.67740254
44MP0002837_dystrophic_cardiac_calcinosis1.66149257
45MP0004043_abnormal_pH_regulation1.66048244
46MP0000013_abnormal_adipose_tissue1.65770199
47MP0001529_abnormal_vocalization1.64242664
48MP0002272_abnormal_nervous_system1.62560288
49MP0003453_abnormal_keratinocyte_physiol1.61578323
50MP0008872_abnormal_physiological_respon1.59358550
51MP0000627_abnormal_mammary_gland1.57741625
52MP0001849_ear_inflammation1.57406576
53MP0003880_abnormal_central_pattern1.57063582
54MP0000462_abnormal_digestive_system1.56526893
55MP0009046_muscle_twitch1.55147181
56MP0000377_abnormal_hair_follicle1.54876205
57MP0005646_abnormal_pituitary_gland1.53939649
58MP0001984_abnormal_olfaction1.52198188
59MP0003566_abnormal_cell_adhesion1.50896080
60MP0002751_abnormal_autonomic_nervous1.50494491
61MP0000467_abnormal_esophagus_morphology1.50306558
62MP0001216_abnormal_epidermal_layer1.50033538
63MP0002735_abnormal_chemical_nociception1.48444900
64MP0001873_stomach_inflammation1.48322038
65MP0005386_behavior/neurological_phenoty1.43285478
66MP0004924_abnormal_behavior1.43285478
67MP0002653_abnormal_ependyma_morphology1.43088612
68MP0002060_abnormal_skin_morphology1.38630805
69MP0001881_abnormal_mammary_gland1.37178213
70MP0002184_abnormal_innervation1.35475198
71MP0003183_abnormal_peptide_metabolism1.34843585
72MP0001756_abnormal_urination1.34809896
73MP0001765_abnormal_ion_homeostasis1.29883981
74MP0010771_integument_phenotype1.29198295
75MP0004233_abnormal_muscle_weight1.27933903
76MP0003879_abnormal_hair_cell1.26061896
77MP0003283_abnormal_digestive_organ1.25803585
78MP0002557_abnormal_social/conspecific_i1.25482663
79MP0001664_abnormal_digestion1.25154808
80MP0003941_abnormal_skin_development1.23598529
81MP0000681_abnormal_thyroid_gland1.22524875
82MP0003329_amyloid_beta_deposits1.22351752
83MP0002736_abnormal_nociception_after1.22234218
84MP0002067_abnormal_sensory_capabilities1.20876913
85MP0002009_preneoplasia1.17737094
86MP0002876_abnormal_thyroid_physiology1.16341492
87MP0004019_abnormal_vitamin_homeostasis1.15296207
88MP0000003_abnormal_adipose_tissue1.13834138
89MP0001346_abnormal_lacrimal_gland1.12957817
90MP0003633_abnormal_nervous_system1.12679174
91MP0004381_abnormal_hair_follicle1.10768077
92MP0002249_abnormal_larynx_morphology1.10690948
93MP0005248_abnormal_Harderian_gland1.10558240
94MP0003123_paternal_imprinting1.09984224
95MP0010352_gastrointestinal_tract_polyps1.09519065
96MP0000751_myopathy1.08668678
97MP0000427_abnormal_hair_cycle1.05121164
98MP0004811_abnormal_neuron_physiology1.03782456
99MP0005535_abnormal_body_temperature1.03554691
100MP0002693_abnormal_pancreas_physiology1.01736409
101MP0004185_abnormal_adipocyte_glucose1.01433921
102MP0008569_lethality_at_weaning1.00464900
103MP0008004_abnormal_stomach_pH0.98514863
104MP0010030_abnormal_orbit_morphology0.97303454
105MP0009643_abnormal_urine_homeostasis0.96745413
106MP0003953_abnormal_hormone_level0.94996654
107MP0000955_abnormal_spinal_cord0.94417499
108MP0009840_abnormal_foam_cell0.92869921
109MP0002877_abnormal_melanocyte_morpholog0.92781090
110MP0002069_abnormal_eating/drinking_beha0.92256545
111MP0002896_abnormal_bone_mineralization0.91788099
112MP0003942_abnormal_urinary_system0.90964225
113MP0009931_abnormal_skin_appearance0.90940432
114MP0001727_abnormal_embryo_implantation0.89833812
115MP0005379_endocrine/exocrine_gland_phen0.89364636
116MP0001486_abnormal_startle_reflex0.87514541
117MP0004264_abnormal_extraembryonic_tissu0.87425827
118MP0003631_nervous_system_phenotype0.86930997
119MP0002066_abnormal_motor_capabilities/c0.86625888
120MP0000778_abnormal_nervous_system0.86093644
121MP0000613_abnormal_salivary_gland0.85629280
122MP0002882_abnormal_neuron_morphology0.85318761
123MP0005408_hypopigmentation0.84787359
124MP0004085_abnormal_heartbeat0.81888061
125MP0008260_abnormal_autophagy0.80604305
126MP0000372_irregular_coat_pigmentation0.80284678
127MP0002078_abnormal_glucose_homeostasis0.80229142
128MP0003638_abnormal_response/metabolism_0.79682870
129MP0001944_abnormal_pancreas_morphology0.79276664
130MP0000477_abnormal_intestine_morphology0.79258613
131MP0001270_distended_abdomen0.78808154
132MP0005165_increased_susceptibility_to0.78674862
133MP0005365_abnormal_bile_salt0.78083573
134MP0000762_abnormal_tongue_morphology0.77794449
135MP0005394_taste/olfaction_phenotype0.77504559
136MP0005499_abnormal_olfactory_system0.77504559
137MP0002168_other_aberrant_phenotype0.77329838
138MP0005636_abnormal_mineral_homeostasis0.76528683
139MP0002089_abnormal_postnatal_growth/wei0.76015484
140MP0000230_abnormal_systemic_arterial0.75518666
141MP0003936_abnormal_reproductive_system0.74619081
142MP0001502_abnormal_circadian_rhythm0.74212548
143MP0000470_abnormal_stomach_morphology0.72754763
144MP0000631_abnormal_neuroendocrine_gland0.72298187
145MP0004885_abnormal_endolymph0.71569685
146MP0004130_abnormal_muscle_cell0.71490016
147MP0008874_decreased_physiological_sensi0.71216293
148MP0001188_hyperpigmentation0.69569567
149MP0004947_skin_inflammation0.69073914
150MP0005167_abnormal_blood-brain_barrier0.68949142
151MP0002132_abnormal_respiratory_system0.68741185
152MP0002166_altered_tumor_susceptibility0.68380468
153MP0009384_cardiac_valve_regurgitation0.67722825
154MP0001666_abnormal_nutrient_absorption0.67225983
155MP0002277_abnormal_respiratory_mucosa0.66783733
156MP0000537_abnormal_urethra_morphology0.64930953
157MP0000858_altered_metastatic_potential0.64362728
158MP0000367_abnormal_coat/_hair0.63921956
159MP0005187_abnormal_penis_morphology0.63240225
160MP0005423_abnormal_somatic_nervous0.61885377
161MP0009379_abnormal_foot_pigmentation0.61732798
162MP0003866_abnormal_defecation0.61050799
163MP0002152_abnormal_brain_morphology0.60874978
164MP0001177_atelectasis0.60431834
165MP0003195_calcinosis0.60308018
166MP0002160_abnormal_reproductive_system0.60001750
167MP0002163_abnormal_gland_morphology0.59879924
168MP0005220_abnormal_exocrine_pancreas0.59817773
169MP0000534_abnormal_ureter_morphology0.59153639
170MP0005375_adipose_tissue_phenotype0.59117055
171MP0010155_abnormal_intestine_physiology0.57089447
172MP0001340_abnormal_eyelid_morphology0.56537802
173MP0001731_abnormal_postnatal_growth0.55794784
174MP0005666_abnormal_adipose_tissue0.55305053

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)8.11349710
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.15131900
3Abnormal respiratory epithelium morphology (HP:0012253)5.82901881
4Abnormal respiratory motile cilium morphology (HP:0005938)5.82901881
5Abnormal respiratory motile cilium physiology (HP:0012261)5.80661101
6Abnormal ciliary motility (HP:0012262)5.40206399
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.37036080
8Absent/shortened dynein arms (HP:0200106)5.37036080
9Myokymia (HP:0002411)5.25575320
10Orthostatic hypotension (HP:0001278)4.89038332
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.80029364
12Nasal polyposis (HP:0100582)4.31037851
13Focal motor seizures (HP:0011153)4.11744206
14Bronchiectasis (HP:0002110)4.08607214
15Abnormal autonomic nervous system physiology (HP:0012332)3.94614809
16Agitation (HP:0000713)3.79369831
17Limb dystonia (HP:0002451)3.74150067
18Amblyopia (HP:0000646)3.71336233
19Visual hallucinations (HP:0002367)3.68142074
20Hyperthyroidism (HP:0000836)3.67687673
21Abnormality of the nasal mucosa (HP:0000433)3.64503391
22Hypotension (HP:0002615)3.61719263
23J-shaped sella turcica (HP:0002680)3.59301915
24Atonic seizures (HP:0010819)3.55782248
25Asymmetry of the thorax (HP:0001555)3.50262005
26Hypoventilation (HP:0002791)3.30914901
27Hypercortisolism (HP:0001578)3.28819726
28Focal seizures (HP:0007359)3.25858764
29Pili torti (HP:0003777)3.20055338
30Abnormality of the distal phalanges of the toes (HP:0010182)3.16544448
31Growth hormone excess (HP:0000845)3.16242161
32Exotropia (HP:0000577)3.12772660
33Right ventricular cardiomyopathy (HP:0011663)3.10755468
34Menstrual irregularities (HP:0000858)3.06194259
35Flat acetabular roof (HP:0003180)3.04323701
36Abnormality of calcium-phosphate metabolism (HP:0100530)3.04237017
37Distal lower limb muscle weakness (HP:0009053)3.01976685
38Neonatal hypoglycemia (HP:0001998)2.99653701
39Pheochromocytoma (HP:0002666)2.98614922
40Short nail (HP:0001799)2.97816581
41Spinal cord compression (HP:0002176)2.89213159
42Absence seizures (HP:0002121)2.78768560
43Hyperactive renin-angiotensin system (HP:0000841)2.78293173
44Atelectasis (HP:0100750)2.78000885
45Hyperparathyroidism (HP:0000843)2.77225679
46Generalized tonic-clonic seizures (HP:0002069)2.74639872
47Male infertility (HP:0003251)2.74331215
48Infertility (HP:0000789)2.71478173
49Hyperphosphatemia (HP:0002905)2.69459377
50Sparse lateral eyebrow (HP:0005338)2.68176118
51Adrenal overactivity (HP:0002717)2.67293389
52Action tremor (HP:0002345)2.66898692
53Facial shape deformation (HP:0011334)2.65833556
54Potter facies (HP:0002009)2.65833556
55Septate vagina (HP:0001153)2.60189199
56Anxiety (HP:0000739)2.57490003
57Decreased circulating renin level (HP:0003351)2.57149898
58Neuroendocrine neoplasm (HP:0100634)2.54054809
59Testicular atrophy (HP:0000029)2.51932478
60Oligomenorrhea (HP:0000876)2.48413126
61Failure to thrive in infancy (HP:0001531)2.48331298
62Absent frontal sinuses (HP:0002688)2.46614905
63Lip pit (HP:0100267)2.43660213
64Ankle clonus (HP:0011448)2.43467366
65Thin bony cortex (HP:0002753)2.42441776
66Bronchitis (HP:0012387)2.42033750
67Amelogenesis imperfecta (HP:0000705)2.39474949
68Concave nail (HP:0001598)2.38207895
69Hyperacusis (HP:0010780)2.36784346
70Testicular neoplasm (HP:0010788)2.35982166
71Cervical subluxation (HP:0003308)2.34481607
72Abnormal hair laboratory examination (HP:0003328)2.34266162
73Febrile seizures (HP:0002373)2.33975043
74Depression (HP:0000716)2.29194860
75Enlarged penis (HP:0000040)2.29182613
76Abdominal distention (HP:0003270)2.27900210
77Dialeptic seizures (HP:0011146)2.27002720
78Recurrent otitis media (HP:0000403)2.25737931
79Upper limb amyotrophy (HP:0009129)2.23950666
80Distal upper limb amyotrophy (HP:0007149)2.23950666
81Ventricular fibrillation (HP:0001663)2.23701169
82Chronic bronchitis (HP:0004469)2.21653132
83Restlessness (HP:0000711)2.21434750
84Congenital glaucoma (HP:0001087)2.21403231
85Hand muscle atrophy (HP:0009130)2.19465322
86Broad face (HP:0000283)2.19387435
87Interstitial pulmonary disease (HP:0006530)2.19381841
88Epileptic encephalopathy (HP:0200134)2.18606362
89Germ cell neoplasia (HP:0100728)2.15821179
90Gout (HP:0001997)2.14967209
91Impaired pain sensation (HP:0007328)2.14269243
92Abnormality of pain sensation (HP:0010832)2.14269243
93Supranuclear gaze palsy (HP:0000605)2.14066419
94Malnutrition (HP:0004395)2.13013276
95Goiter (HP:0000853)2.12608466
96Papilledema (HP:0001085)2.12245600
97Micronodular cirrhosis (HP:0001413)2.10056153
98Bell-shaped thorax (HP:0001591)2.09140344
99Curly hair (HP:0002212)2.08482512
100Progressive cerebellar ataxia (HP:0002073)2.07842916
101Abnormality of the dental root (HP:0006486)2.07497614
102Taurodontia (HP:0000679)2.07497614
103Abnormality of permanent molar morphology (HP:0011071)2.07497614
104Myotonia (HP:0002486)2.07000941
105Hyperaldosteronism (HP:0000859)2.05767052
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04624062
107Syncope (HP:0001279)2.04146073
108Abnormality of molar morphology (HP:0011070)2.03467871
109Abnormality of molar (HP:0011077)2.03467871
110Cerebral inclusion bodies (HP:0100314)2.03431674
111Abnormality of renin-angiotensin system (HP:0000847)2.02146389
112Flattened epiphyses (HP:0003071)2.01553064
113Obstructive sleep apnea (HP:0002870)2.00035982
114Autoamputation (HP:0001218)1.98121210
115Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97690538
116Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.97518551
117Torticollis (HP:0000473)1.97493476
118Urinary glycosaminoglycan excretion (HP:0003541)1.96293802
119Mucopolysacchariduria (HP:0008155)1.96293802
120Epileptiform EEG discharges (HP:0011182)1.96178391
121Renal salt wasting (HP:0000127)1.96003058
122Resting tremor (HP:0002322)1.95341932
123Rhinitis (HP:0012384)1.94252928
124Postural tremor (HP:0002174)1.92643374
125Advanced eruption of teeth (HP:0006288)1.92126438
126EEG with generalized epileptiform discharges (HP:0011198)1.91421617
127Glucose intolerance (HP:0000833)1.89029603
128Ketoacidosis (HP:0001993)1.88155517
129Vascular calcification (HP:0004934)1.85422085
130Dysautonomia (HP:0002459)1.85245946
131Hypokinesia (HP:0002375)1.84650654
132Abnormality of chloride homeostasis (HP:0011422)1.84409537
133Hypokalemia (HP:0002900)1.84232470
134Abnormality of the frontal sinuses (HP:0002687)1.83801146
135Palpitations (HP:0001962)1.83316816
136Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82977514
137Abnormal eating behavior (HP:0100738)1.82250171
138Polyphagia (HP:0002591)1.82126859
139Deformed sella turcica (HP:0002681)1.81064054
140Prolonged QT interval (HP:0001657)1.80704342
141Hypokalemic alkalosis (HP:0001949)1.80277512
142Stridor (HP:0010307)1.80211525
143Hypsarrhythmia (HP:0002521)1.80197623
144Craniofacial dystonia (HP:0012179)1.80067455
145Focal dystonia (HP:0004373)1.77484984
146Psychosis (HP:0000709)1.77034413
147Chronic sinusitis (HP:0011109)1.75042155
148Abnormality of the dental pulp (HP:0006479)1.74039495
149Abnormality of polysaccharide metabolism (HP:0011012)1.73986952
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73986952
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73986952
152Macroorchidism (HP:0000053)1.72604690
153Termporal pattern (HP:0011008)1.71093953
154Insidious onset (HP:0003587)1.71093953
155Striae distensae (HP:0001065)1.70514819
156Diaphragmatic weakness (HP:0009113)1.70435538
157Dysostosis multiplex (HP:0000943)1.69014397
158Thyroid carcinoma (HP:0002890)1.69008081
159Bradycardia (HP:0001662)1.68843116
160Hypoparathyroidism (HP:0000829)1.68467408
161Occipital encephalocele (HP:0002085)1.68071233
162Genital tract atresia (HP:0001827)1.67721220
163Abnormal pupillary function (HP:0007686)1.66057927
164Rapidly progressive (HP:0003678)1.65698016
165Abnormality of the gastric mucosa (HP:0004295)1.65494720
166Microretrognathia (HP:0000308)1.65268065
167Abnormality of aromatic amino acid family metabolism (HP:0004338)1.65068157
168Impaired vibration sensation in the lower limbs (HP:0002166)1.64657740
169Gait imbalance (HP:0002141)1.64633999
170Unilateral renal agenesis (HP:0000122)1.61798759
171Hyperkalemia (HP:0002153)1.61414196
172Poor suck (HP:0002033)1.61188259
173Progressive hearing impairment (HP:0001730)1.60919529
174Retinal atrophy (HP:0001105)1.60251364
175Long toe (HP:0010511)1.58900132
176Neurofibrillary tangles (HP:0002185)1.57903252
177Onycholysis (HP:0001806)1.56485904
178Abnormal EKG (HP:0003115)1.56155964
179Hyperventilation (HP:0002883)1.55959260
180Retinal dysplasia (HP:0007973)1.54931047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK14.28346858
2SIK13.49704532
3NTRK33.22118515
4SMG13.08278008
5PKN22.97628357
6MAP3K22.79275370
7MAP3K42.71665731
8MAP3K122.68830386
9MAP3K92.62780281
10AKT32.62082193
11DAPK22.55656680
12GRK52.44260106
13GRK72.38632246
14ARAF2.25530178
15RPS6KB22.24011471
16NME22.20590737
17EEF2K2.15953848
18ICK1.96815530
19MAP2K71.92269780
20IRAK31.82081447
21MAP2K41.80172499
22KSR21.79003734
23MINK11.78613820
24WNK41.70422038
25LMTK21.69674153
26PAK41.65745331
27CASK1.64487563
28FER1.61130411
29MATK1.59582609
30MUSK1.55018242
31INSRR1.53499783
32DAPK11.48618291
33NEK61.47902711
34MAP2K11.46049455
35EPHA41.45764338
36PTK61.44448367
37FRK1.38837644
38MARK11.35512521
39MAP3K31.33049340
40MYLK1.26783002
41CAMKK21.26272299
42EPHB11.25381354
43VRK21.24669432
44MAPK151.18393973
45MAPKAPK51.16690166
46NTRK21.14785882
47CSNK1G21.13674073
48TESK21.09554907
49EIF2AK11.08208247
50CDK51.06475599
51TESK11.05899574
52LRRK21.05869126
53PHKG11.05735540
54PHKG21.05735540
55ADRBK11.05016989
56PAK31.03344434
57OXSR11.02962712
58CAMKK11.02509265
59NME11.01833248
60UHMK11.01825925
61STK391.01165102
62MAP3K10.99416555
63PRKD20.97388993
64MST40.96786878
65FGFR40.96541494
66PNCK0.96009417
67CAMK2B0.95905436
68PLK20.95868031
69ILK0.95693557
70PIK3CA0.95675092
71PRKD30.92354569
72PRKCE0.92053643
73PRKCG0.90786719
74CSNK1G30.87468152
75MAP2K20.87433976
76SGK4940.86907265
77SGK2230.86907265
78CDK120.86361991
79RET0.84744694
80BRAF0.82878067
81MAPKAPK30.82161452
82MST1R0.81155939
83MTOR0.80360224
84RPS6KA20.79992435
85PTK20.79796887
86CAMK2G0.79189967
87GRK60.78695717
88PAK60.75165714
89CAMK2A0.73694925
90CAMK2D0.70857394
91SIK30.70251236
92PRKG20.68738805
93WNK30.68424528
94TBK10.66126190
95CDK190.65617979
96PDGFRA0.65123299
97PRKCI0.62564280
98TAOK20.62550407
99EPHA20.61549204
100CDK70.61307325
101PTK2B0.60764234
102LATS20.60558670
103WNK10.60140557
104TRIB30.58040054
105PDK40.57777068
106PDK30.57777068
107CHUK0.56615416
108MAPK130.56429140
109PDK20.55560969
110DAPK30.54808623
111PIM20.54175718
112PRKCH0.53812788
113TAOK10.52670265
114LIMK10.52581084
115CSNK1G10.51976741
116CDK140.50936907
117PDPK10.50756340
118RIPK10.49060935
119HIPK20.48948008
120ERN10.48445967
121TNK20.48364560
122CDK180.48298607
123TAOK30.47401239
124CDK150.46898348
125EPHB20.45286138
126ERBB20.44111503
127TYRO30.44064091
128IRAK20.43721075
129MAP2K60.42347021
130KSR10.41845725
131PBK0.41311946
132TSSK60.39947939
133SCYL20.39090759
134MARK20.37568924
135STK380.37310508
136MET0.36776434
137CDK11A0.36653766
138MAPKAPK20.35892722
139PRKD10.35796401
140CDC42BPA0.32486889
141MAP3K110.28830067
142AKT20.28412363
143AURKA0.27369747
144PRPF4B0.24834027
145MELK0.23501611
146TRPM70.23478545
147RPS6KB10.21101801
148PDK10.19943970
149RPS6KC10.17097456
150RPS6KL10.17097456
151TTK0.16742915
152PRKCD0.15938094
153ABL20.15190568
154TAF10.14394710
155IRAK10.13765877
156DMPK0.13547992

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.19811549
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.74185250
3Collecting duct acid secretion_Homo sapiens_hsa049662.71962789
4Vibrio cholerae infection_Homo sapiens_hsa051102.55243047
5Amphetamine addiction_Homo sapiens_hsa050312.41144926
6Cocaine addiction_Homo sapiens_hsa050302.34539674
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26199991
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.15458641
9Insulin secretion_Homo sapiens_hsa049112.15059047
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.14822657
11Olfactory transduction_Homo sapiens_hsa047402.11385416
12Dopaminergic synapse_Homo sapiens_hsa047282.04452845
13Sphingolipid metabolism_Homo sapiens_hsa006001.95728089
14Tyrosine metabolism_Homo sapiens_hsa003501.85573160
15Oxidative phosphorylation_Homo sapiens_hsa001901.83079146
16Phenylalanine metabolism_Homo sapiens_hsa003601.79966486
17Circadian entrainment_Homo sapiens_hsa047131.79124474
18Cholinergic synapse_Homo sapiens_hsa047251.76747468
19Salivary secretion_Homo sapiens_hsa049701.75934273
20Renin secretion_Homo sapiens_hsa049241.74832881
21Glutathione metabolism_Homo sapiens_hsa004801.73490390
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.71400865
23Serotonergic synapse_Homo sapiens_hsa047261.65970934
24Gastric acid secretion_Homo sapiens_hsa049711.64561132
25Other glycan degradation_Homo sapiens_hsa005111.63927962
26Taste transduction_Homo sapiens_hsa047421.61002256
27Long-term potentiation_Homo sapiens_hsa047201.58875515
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56580346
29Sulfur metabolism_Homo sapiens_hsa009201.55640643
30Nicotine addiction_Homo sapiens_hsa050331.55453184
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54506797
32Chemical carcinogenesis_Homo sapiens_hsa052041.53559784
33Pancreatic secretion_Homo sapiens_hsa049721.53303260
34Hepatitis C_Homo sapiens_hsa051601.51837017
35Notch signaling pathway_Homo sapiens_hsa043301.49496935
36Endometrial cancer_Homo sapiens_hsa052131.48723488
37GABAergic synapse_Homo sapiens_hsa047271.48056648
38Pentose phosphate pathway_Homo sapiens_hsa000301.45083929
39Parkinsons disease_Homo sapiens_hsa050121.42841685
40beta-Alanine metabolism_Homo sapiens_hsa004101.36237683
41Morphine addiction_Homo sapiens_hsa050321.34645617
42Thyroid hormone synthesis_Homo sapiens_hsa049181.32878963
43Glutamatergic synapse_Homo sapiens_hsa047241.32553662
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.30754816
45Alzheimers disease_Homo sapiens_hsa050101.27643421
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23452922
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.22537812
48GnRH signaling pathway_Homo sapiens_hsa049121.19460342
49Galactose metabolism_Homo sapiens_hsa000521.19307162
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19146726
51Long-term depression_Homo sapiens_hsa047301.17733198
52Bladder cancer_Homo sapiens_hsa052191.17350581
53Gap junction_Homo sapiens_hsa045401.16083102
54AMPK signaling pathway_Homo sapiens_hsa041521.16066259
55mTOR signaling pathway_Homo sapiens_hsa041501.15268423
56Vitamin digestion and absorption_Homo sapiens_hsa049771.14877309
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11488812
58Insulin resistance_Homo sapiens_hsa049311.11132906
59Estrogen signaling pathway_Homo sapiens_hsa049151.11001400
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09772277
61VEGF signaling pathway_Homo sapiens_hsa043701.09603287
62Histidine metabolism_Homo sapiens_hsa003401.08968500
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08623897
64Sulfur relay system_Homo sapiens_hsa041221.08489957
65Vitamin B6 metabolism_Homo sapiens_hsa007501.04630449
66Acute myeloid leukemia_Homo sapiens_hsa052211.03934860
67Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03860402
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00968924
69Bile secretion_Homo sapiens_hsa049761.00895973
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98776154
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98262106
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.97686221
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96447202
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96268195
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95971548
76ABC transporters_Homo sapiens_hsa020100.95504743
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93262831
78Calcium signaling pathway_Homo sapiens_hsa040200.92949216
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92897533
80Oxytocin signaling pathway_Homo sapiens_hsa049210.91722419
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89481466
82Chronic myeloid leukemia_Homo sapiens_hsa052200.87023622
83Prostate cancer_Homo sapiens_hsa052150.85659965
84Cardiac muscle contraction_Homo sapiens_hsa042600.84795019
85Endocytosis_Homo sapiens_hsa041440.83657752
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.83201736
87cAMP signaling pathway_Homo sapiens_hsa040240.83116753
88Melanogenesis_Homo sapiens_hsa049160.81952037
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81231131
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80945000
91Type II diabetes mellitus_Homo sapiens_hsa049300.79840351
92Non-small cell lung cancer_Homo sapiens_hsa052230.79178682
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78744973
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77039119
95Renal cell carcinoma_Homo sapiens_hsa052110.76363076
96Arginine biosynthesis_Homo sapiens_hsa002200.74689241
97Huntingtons disease_Homo sapiens_hsa050160.73534831
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72831706
99Glycerolipid metabolism_Homo sapiens_hsa005610.71412120
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71214448
101Glucagon signaling pathway_Homo sapiens_hsa049220.70981494
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70383196
103Tryptophan metabolism_Homo sapiens_hsa003800.68650507
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68533847
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.67914106
106Pancreatic cancer_Homo sapiens_hsa052120.67181935
107Biosynthesis of amino acids_Homo sapiens_hsa012300.65649914
108Mineral absorption_Homo sapiens_hsa049780.63183949
109Pyruvate metabolism_Homo sapiens_hsa006200.61685149
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61056353
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60195865
112Protein export_Homo sapiens_hsa030600.60071505
113Dorso-ventral axis formation_Homo sapiens_hsa043200.59439280
114Ovarian steroidogenesis_Homo sapiens_hsa049130.59016233
115Prolactin signaling pathway_Homo sapiens_hsa049170.57251946
116Proteoglycans in cancer_Homo sapiens_hsa052050.56842808
117Prion diseases_Homo sapiens_hsa050200.56725634
118Alcoholism_Homo sapiens_hsa050340.54330042
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.53358781
120Fatty acid elongation_Homo sapiens_hsa000620.52829031
121Adherens junction_Homo sapiens_hsa045200.50479831
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50143821
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49588219
124Fatty acid biosynthesis_Homo sapiens_hsa000610.48842466
125Thyroid cancer_Homo sapiens_hsa052160.47082807
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46389431
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.46318984
128Glioma_Homo sapiens_hsa052140.44598536
129Lysosome_Homo sapiens_hsa041420.44553160
130Starch and sucrose metabolism_Homo sapiens_hsa005000.44105558
131Phagosome_Homo sapiens_hsa041450.42972810
132Hippo signaling pathway_Homo sapiens_hsa043900.42966480
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42743794
134Insulin signaling pathway_Homo sapiens_hsa049100.42120606
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.41998803
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41862888
137N-Glycan biosynthesis_Homo sapiens_hsa005100.41594588
138Butanoate metabolism_Homo sapiens_hsa006500.41334836
139Rheumatoid arthritis_Homo sapiens_hsa053230.40476711
140Protein digestion and absorption_Homo sapiens_hsa049740.40364921
141Carbon metabolism_Homo sapiens_hsa012000.39979791
142Fat digestion and absorption_Homo sapiens_hsa049750.39597980
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39357120
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.39093409
145Folate biosynthesis_Homo sapiens_hsa007900.38978423
146ErbB signaling pathway_Homo sapiens_hsa040120.38734852
147Dilated cardiomyopathy_Homo sapiens_hsa054140.37987452
148Tight junction_Homo sapiens_hsa045300.36659314
149Fructose and mannose metabolism_Homo sapiens_hsa000510.34323731
150Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33019756
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33005642
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32995820
153Choline metabolism in cancer_Homo sapiens_hsa052310.32739977
154Axon guidance_Homo sapiens_hsa043600.32372689
155Inositol phosphate metabolism_Homo sapiens_hsa005620.32166000
156Arginine and proline metabolism_Homo sapiens_hsa003300.31560536
157Regulation of autophagy_Homo sapiens_hsa041400.30733125
158Neurotrophin signaling pathway_Homo sapiens_hsa047220.29248751
159Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28585442

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