CXXC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70632622
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70156823
3neuron cell-cell adhesion (GO:0007158)4.64743616
4neuron fate determination (GO:0048664)4.29289286
5nucleobase catabolic process (GO:0046113)4.24578372
6behavioral response to nicotine (GO:0035095)4.21773216
7response to pheromone (GO:0019236)4.13980541
8presynaptic membrane organization (GO:0097090)4.10621679
9regulation of synaptic vesicle exocytosis (GO:2000300)4.10173921
10neuron recognition (GO:0008038)4.08243961
11synaptic vesicle exocytosis (GO:0016079)4.04052945
12presynaptic membrane assembly (GO:0097105)4.03964365
13dendritic spine morphogenesis (GO:0060997)3.99159743
14vocalization behavior (GO:0071625)3.93995722
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.85559860
16axonal fasciculation (GO:0007413)3.73879912
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.71812002
18protein localization to synapse (GO:0035418)3.69248714
19layer formation in cerebral cortex (GO:0021819)3.60367489
20positive regulation of synapse assembly (GO:0051965)3.54201190
21water-soluble vitamin biosynthetic process (GO:0042364)3.52490095
22regulation of synaptic vesicle transport (GO:1902803)3.50807078
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.50082186
24cerebellar Purkinje cell differentiation (GO:0021702)3.41404630
25regulation of glutamate receptor signaling pathway (GO:1900449)3.40788014
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36393172
27limb bud formation (GO:0060174)3.35210222
28epithelial cilium movement (GO:0003351)3.34124436
29innervation (GO:0060384)3.33117373
30intraciliary transport (GO:0042073)3.32672288
31regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32394211
32kidney morphogenesis (GO:0060993)3.29997063
33postsynaptic membrane organization (GO:0001941)3.28600624
34detection of calcium ion (GO:0005513)3.25225834
35glutamate secretion (GO:0014047)3.24242567
36pyrimidine nucleobase catabolic process (GO:0006208)3.24082062
37negative regulation of cytosolic calcium ion concentration (GO:0051481)3.22354133
38neurotransmitter secretion (GO:0007269)3.21838691
39cell migration in hindbrain (GO:0021535)3.20455741
40regulation of synapse assembly (GO:0051963)3.15889616
41synaptic vesicle maturation (GO:0016188)3.15350414
42neuronal action potential propagation (GO:0019227)3.13978105
43regulation of respiratory system process (GO:0044065)3.13887839
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11335336
45synaptic transmission, glutamatergic (GO:0035249)3.10090988
46insulin secretion (GO:0030073)3.09114103
47astrocyte differentiation (GO:0048708)3.08037105
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.07971606
49locomotory exploration behavior (GO:0035641)3.06774744
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.06700356
51spinal cord motor neuron differentiation (GO:0021522)3.05199114
52neurotransmitter-gated ion channel clustering (GO:0072578)3.00805094
53auditory behavior (GO:0031223)2.99737697
54startle response (GO:0001964)2.98326617
55neuron-neuron synaptic transmission (GO:0007270)2.98057226
56dendrite morphogenesis (GO:0048813)2.95839111
57cilium movement (GO:0003341)2.91807286
58sequestering of actin monomers (GO:0042989)2.91595230
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91279433
60serotonin metabolic process (GO:0042428)2.91210143
61cilium assembly (GO:0042384)2.88404156
62cerebellum development (GO:0021549)2.88006937
63regulation of vesicle fusion (GO:0031338)2.87748881
64positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87622662
65regulation of respiratory gaseous exchange (GO:0043576)2.87366099
66cilium organization (GO:0044782)2.87287895
67synapse assembly (GO:0007416)2.86766766
68glutamate receptor signaling pathway (GO:0007215)2.86399505
69regulation of calcium ion-dependent exocytosis (GO:0017158)2.85841503
70neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.85774946
71somite development (GO:0061053)2.84290210
72hippocampus development (GO:0021766)2.83282065
73olfactory bulb development (GO:0021772)2.82596627
74nonmotile primary cilium assembly (GO:0035058)2.82096583
75epithelial cell fate commitment (GO:0072148)2.81768392
76mechanosensory behavior (GO:0007638)2.81507125
77regulation of neuronal synaptic plasticity (GO:0048168)2.81321066
78synaptic vesicle endocytosis (GO:0048488)2.81212232
79endocrine pancreas development (GO:0031018)2.80794617
80neuronal action potential (GO:0019228)2.78699731
81exploration behavior (GO:0035640)2.78403579
82protein localization to cilium (GO:0061512)2.77800372
83striatum development (GO:0021756)2.77122673
84neuron fate specification (GO:0048665)2.76916490
85neurotransmitter transport (GO:0006836)2.75618970
86membrane hyperpolarization (GO:0060081)2.75168516
87transmission of nerve impulse (GO:0019226)2.75006949
88limb development (GO:0060173)2.74902920
89appendage development (GO:0048736)2.74902920
90regulation of postsynaptic membrane potential (GO:0060078)2.74328284
91regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74056830
92central nervous system projection neuron axonogenesis (GO:0021952)2.72867293
93positive regulation of oligodendrocyte differentiation (GO:0048714)2.72736981
94regulation of neurotransmitter secretion (GO:0046928)2.70841671
95cell differentiation in hindbrain (GO:0021533)2.70618174
96hindbrain development (GO:0030902)2.70611297
97dendrite development (GO:0016358)2.67866332
98regulation of excitatory postsynaptic membrane potential (GO:0060079)2.67278617
99negative regulation of microtubule polymerization (GO:0031115)2.67051988
100positive regulation of membrane potential (GO:0045838)2.66107516
101smoothened signaling pathway (GO:0007224)2.65288299
102cAMP-mediated signaling (GO:0019933)2.65106680
103membrane depolarization during action potential (GO:0086010)2.65038907
104dopamine biosynthetic process (GO:0042416)2.64512427
105urinary tract smooth muscle contraction (GO:0014848)2.64210704
106positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.63491640
107gamma-aminobutyric acid transport (GO:0015812)2.62764870
108mating behavior (GO:0007617)2.62700866
109regulation of synapse organization (GO:0050807)2.61272868
110nephron tubule morphogenesis (GO:0072078)2.61009525
111nephron epithelium morphogenesis (GO:0072088)2.61009525
112cilium morphogenesis (GO:0060271)2.60771859
113neuronal stem cell maintenance (GO:0097150)2.60142698
114ubiquinone metabolic process (GO:0006743)2.59669523
115brain morphogenesis (GO:0048854)2.59158594
116synapse organization (GO:0050808)2.58414529
117axoneme assembly (GO:0035082)2.57977172
118primary amino compound metabolic process (GO:1901160)2.57930198
119proline transport (GO:0015824)2.57588678
120growth hormone secretion (GO:0030252)2.56856411
121gamma-aminobutyric acid signaling pathway (GO:0007214)2.55709220
122response to auditory stimulus (GO:0010996)2.55669111
123cochlea development (GO:0090102)2.54965494
124regulation of synapse structural plasticity (GO:0051823)2.54437881
125cell differentiation in spinal cord (GO:0021515)2.52578423
126dendritic spine organization (GO:0097061)2.52456710
127establishment of synaptic vesicle localization (GO:0097480)2.52134513
128synaptic vesicle transport (GO:0048489)2.52134513
129signal release (GO:0023061)2.51901210
130positive regulation of synapse maturation (GO:0090129)2.51766445
131eye photoreceptor cell differentiation (GO:0001754)2.51645774
132photoreceptor cell differentiation (GO:0046530)2.51645774
133negative regulation of neurotransmitter transport (GO:0051589)2.51514190
134positive regulation of gastrulation (GO:2000543)2.51477441
135regulation of exocytosis (GO:0017157)2.50616321
136membrane depolarization (GO:0051899)2.50314651
137positive regulation of exocytosis (GO:0045921)2.50021574
138cerebellar Purkinje cell layer development (GO:0021680)2.49920825
139peptide hormone secretion (GO:0030072)2.49679436
140behavioral response to ethanol (GO:0048149)2.49213481
141negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47372934
142regulation of cilium movement (GO:0003352)2.47006572
143calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46793540
144retinal ganglion cell axon guidance (GO:0031290)2.46655881
145regulation of neurotransmitter transport (GO:0051588)2.45578159
146regulation of action potential (GO:0098900)2.44361808
147synaptic transmission, cholinergic (GO:0007271)2.44067529
148glycerophospholipid catabolic process (GO:0046475)2.43418561
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43209665
150toxin metabolic process (GO:0009404)2.42735556
151central nervous system neuron axonogenesis (GO:0021955)2.42149054
152regulation of timing of cell differentiation (GO:0048505)2.41720504
153protein polyglutamylation (GO:0018095)2.41261977
154protein complex biogenesis (GO:0070271)2.40674072
155cornea development in camera-type eye (GO:0061303)2.40560607
156dopamine transport (GO:0015872)2.40356642
157pancreas development (GO:0031016)2.38424982
158neural tube formation (GO:0001841)2.38316002
159somite rostral/caudal axis specification (GO:0032525)2.38153628
160alanine transport (GO:0032328)2.35569621
161reflex (GO:0060004)2.35276667
162cranial nerve development (GO:0021545)2.34461273
163renal tubule morphogenesis (GO:0061333)2.33904792
164negative regulation of synaptic transmission, GABAergic (GO:0032229)2.31384736
165type B pancreatic cell development (GO:0003323)2.30406564
166auditory receptor cell differentiation (GO:0042491)2.30137167
167spinal cord development (GO:0021510)2.30087830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77783450
2GBX2_23144817_ChIP-Seq_PC3_Human3.63253627
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.78961516
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77159337
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76314848
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72338948
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67592313
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52550393
9REST_21632747_ChIP-Seq_MESCs_Mouse2.51104185
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35702499
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35702499
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.33711738
13* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33653349
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33577116
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32334007
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.32097659
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31477280
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25752273
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20533803
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19790787
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17533251
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11523160
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08817316
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02920467
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.00685414
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.99486587
27TAF15_26573619_Chip-Seq_HEK293_Human1.92315902
28IGF1R_20145208_ChIP-Seq_DFB_Human1.89094534
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88811741
30DROSHA_22980978_ChIP-Seq_HELA_Human1.86826532
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.83387406
32EWS_26573619_Chip-Seq_HEK293_Human1.81175719
33RNF2_27304074_Chip-Seq_NSC_Mouse1.79736789
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78595602
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77907898
36* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71734729
37ZNF274_21170338_ChIP-Seq_K562_Hela1.70442509
38P300_19829295_ChIP-Seq_ESCs_Human1.64506674
39SMAD4_21799915_ChIP-Seq_A2780_Human1.63483859
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62054387
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59923505
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58466831
43AR_21572438_ChIP-Seq_LNCaP_Human1.58119620
44* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57670173
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57326017
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.56133682
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53982258
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50528273
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.46980330
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.44436012
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.43952498
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41362775
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39680727
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38983400
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37665759
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37068981
57VDR_22108803_ChIP-Seq_LS180_Human1.32794206
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32562707
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.30656062
60CBP_20019798_ChIP-Seq_JUKART_Human1.29245848
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29245848
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26736198
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26447607
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25264751
65* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24115390
66STAT3_23295773_ChIP-Seq_U87_Human1.21664341
67* RING1B_27294783_Chip-Seq_NPCs_Mouse1.21460911
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19895523
69FUS_26573619_Chip-Seq_HEK293_Human1.19851037
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16897724
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.16731686
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16054324
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14567204
74AR_25329375_ChIP-Seq_VCAP_Human1.13751075
75* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13629436
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12660166
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12635428
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12106455
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12071216
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11963729
81RUNX2_22187159_ChIP-Seq_PCA_Human1.11797991
82AR_19668381_ChIP-Seq_PC3_Human1.11781109
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11212307
84TCF4_22108803_ChIP-Seq_LS180_Human1.10880987
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10048872
86P53_22387025_ChIP-Seq_ESCs_Mouse1.09340649
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08236407
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07437170
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07419195
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07419195
91TCF4_23295773_ChIP-Seq_U87_Human1.06736183
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06322274
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.05984080
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05475810
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05459741
96* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05428466
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.05352943
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05259164
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05149779
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04983000
101* NANOG_18555785_Chip-Seq_ESCs_Mouse1.04137815
102SOX2_19829295_ChIP-Seq_ESCs_Human1.04095848
103NANOG_19829295_ChIP-Seq_ESCs_Human1.04095848
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02566035
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02379212
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.02272236
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.02181468
108SMAD3_21741376_ChIP-Seq_ESCs_Human1.02152532
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01958135
110ER_23166858_ChIP-Seq_MCF-7_Human1.01804142
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00630329
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99804155
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96699695
114* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94395134
115AHR_22903824_ChIP-Seq_MCF-7_Human0.93320375
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92313132
117* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91972581
118BCAT_22108803_ChIP-Seq_LS180_Human0.91639233
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90819243
120* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90313682
121* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89521188
122HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89039455
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88184401
124* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87085688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.80883256
2MP0003122_maternal_imprinting3.51391492
3MP0005645_abnormal_hypothalamus_physiol3.10255847
4MP0004859_abnormal_synaptic_plasticity3.03912854
5MP0004270_analgesia2.87825491
6MP0006276_abnormal_autonomic_nervous2.74062219
7MP0003635_abnormal_synaptic_transmissio2.69421276
8MP0003136_yellow_coat_color2.44242307
9MP0010386_abnormal_urinary_bladder2.41710351
10MP0002638_abnormal_pupillary_reflex2.40695110
11MP0005423_abnormal_somatic_nervous2.39517102
12MP0002734_abnormal_mechanical_nocicepti2.29641702
13MP0002063_abnormal_learning/memory/cond2.29581602
14MP0006072_abnormal_retinal_apoptosis2.21717752
15MP0005646_abnormal_pituitary_gland2.18965589
16MP0002909_abnormal_adrenal_gland2.16544688
17MP0000778_abnormal_nervous_system2.15738039
18MP0000566_synostosis2.15302425
19MP0009745_abnormal_behavioral_response2.10739793
20MP0001984_abnormal_olfaction2.09862944
21MP0002572_abnormal_emotion/affect_behav2.09338721
22MP0008877_abnormal_DNA_methylation2.02616494
23MP0004133_heterotaxia2.01167155
24MP0002064_seizures1.98622174
25MP0009780_abnormal_chondrocyte_physiolo1.96368585
26MP0002184_abnormal_innervation1.94393248
27MP0001968_abnormal_touch/_nociception1.87834628
28MP0001486_abnormal_startle_reflex1.85733923
29MP0002272_abnormal_nervous_system1.84638960
30MP0009046_muscle_twitch1.82438199
31MP0002557_abnormal_social/conspecific_i1.81138010
32MP0001529_abnormal_vocalization1.76576017
33MP0001502_abnormal_circadian_rhythm1.74841858
34MP0002102_abnormal_ear_morphology1.73965704
35MP0003121_genomic_imprinting1.73659517
36MP0003283_abnormal_digestive_organ1.72379455
37MP0002733_abnormal_thermal_nociception1.72314014
38MP0002735_abnormal_chemical_nociception1.71532524
39MP0001188_hyperpigmentation1.68555515
40MP0005499_abnormal_olfactory_system1.67950262
41MP0005394_taste/olfaction_phenotype1.67950262
42MP0003787_abnormal_imprinting1.66525646
43MP0005551_abnormal_eye_electrophysiolog1.62902044
44MP0000631_abnormal_neuroendocrine_gland1.62673332
45MP0001970_abnormal_pain_threshold1.61431760
46MP0002067_abnormal_sensory_capabilities1.58763412
47MP0008789_abnormal_olfactory_epithelium1.57422775
48MP0001440_abnormal_grooming_behavior1.54365164
49MP0006292_abnormal_olfactory_placode1.53559027
50MP0000013_abnormal_adipose_tissue1.53473276
51MP0002837_dystrophic_cardiac_calcinosis1.51965678
52MP0005379_endocrine/exocrine_gland_phen1.44331689
53MP0000955_abnormal_spinal_cord1.39940044
54MP0003195_calcinosis1.38509590
55MP0002882_abnormal_neuron_morphology1.35946081
56MP0005253_abnormal_eye_physiology1.34723464
57MP0004811_abnormal_neuron_physiology1.34502385
58MP0005386_behavior/neurological_phenoty1.34258175
59MP0004924_abnormal_behavior1.34258175
60MP0001944_abnormal_pancreas_morphology1.32384339
61MP0002822_catalepsy1.28277442
62MP0003890_abnormal_embryonic-extraembry1.28013842
63MP0002693_abnormal_pancreas_physiology1.27877051
64MP0001501_abnormal_sleep_pattern1.27582957
65MP0002751_abnormal_autonomic_nervous1.23683922
66MP0001485_abnormal_pinna_reflex1.23469991
67MP0002928_abnormal_bile_duct1.23466815
68MP0003183_abnormal_peptide_metabolism1.20635796
69MP0004043_abnormal_pH_regulation1.20084649
70MP0002736_abnormal_nociception_after1.16743133
71MP0005084_abnormal_gallbladder_morpholo1.12054874
72MP0008569_lethality_at_weaning1.10456573
73MP0002234_abnormal_pharynx_morphology1.10145917
74MP0003011_delayed_dark_adaptation1.09921842
75MP0002066_abnormal_motor_capabilities/c1.08732455
76MP0002152_abnormal_brain_morphology1.08389783
77MP0001905_abnormal_dopamine_level1.07874926
78MP0004742_abnormal_vestibular_system1.03928251
79MP0003938_abnormal_ear_development1.03715385
80MP0002069_abnormal_eating/drinking_beha1.01701268
81MP0002752_abnormal_somatic_nervous1.01484008
82MP0008961_abnormal_basal_metabolism1.00941841
83MP0002653_abnormal_ependyma_morphology1.00040671
84MP0000427_abnormal_hair_cycle0.99681261
85MP0004145_abnormal_muscle_electrophysio0.97815945
86MP0000647_abnormal_sebaceous_gland0.97181498
87MP0000678_abnormal_parathyroid_gland0.96077597
88MP0003879_abnormal_hair_cell0.95651005
89MP0003119_abnormal_digestive_system0.94742596
90MP0000538_abnormal_urinary_bladder0.93520160
91MP0008995_early_reproductive_senescence0.93376825
92MP0004142_abnormal_muscle_tone0.88476312
93MP0000462_abnormal_digestive_system0.87803125
94MP0004885_abnormal_endolymph0.87286724
95MP0005187_abnormal_penis_morphology0.86919601
96MP0005391_vision/eye_phenotype0.85044299
97MP0003633_abnormal_nervous_system0.84823065
98MP0000569_abnormal_digit_pigmentation0.84723002
99MP0005248_abnormal_Harderian_gland0.84227704
100MP0003937_abnormal_limbs/digits/tail_de0.83001754
101MP0001986_abnormal_taste_sensitivity0.82357003
102MP0000026_abnormal_inner_ear0.82272653
103MP0002229_neurodegeneration0.81829158
104MP0003861_abnormal_nervous_system0.80529557
105MP0002163_abnormal_gland_morphology0.80456461
106MP0000383_abnormal_hair_follicle0.79035700
107MP0004085_abnormal_heartbeat0.78605337
108MP0002078_abnormal_glucose_homeostasis0.76277080
109MP0001293_anophthalmia0.76165881
110MP0005535_abnormal_body_temperature0.74654367
111MP0001963_abnormal_hearing_physiology0.74319717
112MP0005195_abnormal_posterior_eye0.73074829
113MP0005220_abnormal_exocrine_pancreas0.72297889
114MP0002876_abnormal_thyroid_physiology0.72162086
115MP0002938_white_spotting0.71867379
116MP0003953_abnormal_hormone_level0.71799498
117MP0004858_abnormal_nervous_system0.71786252
118MP0000049_abnormal_middle_ear0.71143968

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.53920015
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.80529310
3Failure to thrive in infancy (HP:0001531)3.79277208
4Focal seizures (HP:0007359)3.64385376
5Agitation (HP:0000713)3.49194414
6Pancreatic fibrosis (HP:0100732)3.47236694
7Visual hallucinations (HP:0002367)3.44716209
8Epileptic encephalopathy (HP:0200134)3.35123442
9Gait imbalance (HP:0002141)3.33191497
10Molar tooth sign on MRI (HP:0002419)3.32910382
11Febrile seizures (HP:0002373)3.32025414
12Nephronophthisis (HP:0000090)3.18481034
13Intestinal atresia (HP:0011100)3.16188237
14Pancreatic cysts (HP:0001737)3.14121325
15Atonic seizures (HP:0010819)3.12999225
16Polyphagia (HP:0002591)3.11349991
17Progressive cerebellar ataxia (HP:0002073)3.09137665
18Myokymia (HP:0002411)3.08129720
19Limb dystonia (HP:0002451)3.05367444
20Medial flaring of the eyebrow (HP:0010747)3.03122489
21Congenital primary aphakia (HP:0007707)2.89751313
22Hypothermia (HP:0002045)2.86866044
23EEG with generalized epileptiform discharges (HP:0011198)2.84917992
24Epileptiform EEG discharges (HP:0011182)2.84371192
25Absence seizures (HP:0002121)2.78168879
26Abnormality of calcium-phosphate metabolism (HP:0100530)2.77895417
27Nephrogenic diabetes insipidus (HP:0009806)2.69868296
28Large for gestational age (HP:0001520)2.69698234
29Hypsarrhythmia (HP:0002521)2.68758535
30Hyperinsulinemic hypoglycemia (HP:0000825)2.67907281
31Pheochromocytoma (HP:0002666)2.66877545
32Symptomatic seizures (HP:0011145)2.63816392
33Dialeptic seizures (HP:0011146)2.62207877
34Abnormality of the renal medulla (HP:0100957)2.58710764
35Amblyopia (HP:0000646)2.58443767
36Oligodactyly (hands) (HP:0001180)2.54817190
37Optic nerve hypoplasia (HP:0000609)2.49082538
38Broad-based gait (HP:0002136)2.47606455
39Hyperventilation (HP:0002883)2.46174737
40Abnormal eating behavior (HP:0100738)2.46060850
41Supranuclear gaze palsy (HP:0000605)2.44543321
42Vaginal atresia (HP:0000148)2.44528123
43Hypoglycemic seizures (HP:0002173)2.43505960
44Generalized tonic-clonic seizures (HP:0002069)2.42481148
45Genital tract atresia (HP:0001827)2.42135422
46Specific learning disability (HP:0001328)2.40979975
47Exotropia (HP:0000577)2.39377956
48Excessive salivation (HP:0003781)2.34904139
49Drooling (HP:0002307)2.34904139
50Decreased circulating renin level (HP:0003351)2.32218316
51Congenital stationary night blindness (HP:0007642)2.30768555
52Hypoventilation (HP:0002791)2.29250173
53Ankle clonus (HP:0011448)2.29145113
54Central scotoma (HP:0000603)2.27790988
55Protruding tongue (HP:0010808)2.27734713
56Septo-optic dysplasia (HP:0100842)2.27721095
57Chronic hepatic failure (HP:0100626)2.27478461
58Absent eyebrow (HP:0002223)2.27436891
59Neuroendocrine neoplasm (HP:0100634)2.25580580
60Gastrointestinal atresia (HP:0002589)2.25368557
61Postaxial hand polydactyly (HP:0001162)2.23584920
62Anxiety (HP:0000739)2.21681894
63Aplasia/Hypoplasia of the lens (HP:0008063)2.20898187
64Abnormal hair whorl (HP:0010721)2.20137079
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19284165
66Progressive macrocephaly (HP:0004481)2.18816601
67Esotropia (HP:0000565)2.17736883
68Cystic liver disease (HP:0006706)2.16817946
69Absent speech (HP:0001344)2.16817162
70Truncal ataxia (HP:0002078)2.16107711
71Hepatoblastoma (HP:0002884)2.16095133
72Labial hypoplasia (HP:0000066)2.15707059
73Gaze-evoked nystagmus (HP:0000640)2.15503460
74Hyperthyroidism (HP:0000836)2.13553904
75Depression (HP:0000716)2.08859722
76Papillary thyroid carcinoma (HP:0002895)2.08853218
77Hemiparesis (HP:0001269)2.08427302
78Aqueductal stenosis (HP:0002410)2.03492234
79Abnormality of macular pigmentation (HP:0008002)2.01534306
80Bifid tongue (HP:0010297)1.99526596
81Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98678411
82Hypoplasia of the brainstem (HP:0002365)1.98678411
83Sclerocornea (HP:0000647)1.98144549
84Abnormal pancreas size (HP:0012094)1.97126550
85Pachygyria (HP:0001302)1.96326551
86Abnormal rod and cone electroretinograms (HP:0008323)1.95176790
87Papilledema (HP:0001085)1.93189253
88Retinal atrophy (HP:0001105)1.92848283
89Bony spicule pigmentary retinopathy (HP:0007737)1.90491042
90Open mouth (HP:0000194)1.90460684
91Prolonged QT interval (HP:0001657)1.90353431
92Postaxial foot polydactyly (HP:0001830)1.89109214
93Sleep apnea (HP:0010535)1.88862936
94Hypoplastic female external genitalia (HP:0012815)1.87818707
95Anophthalmia (HP:0000528)1.86211862
96Retinal dysplasia (HP:0007973)1.85361684
97Poor coordination (HP:0002370)1.85269134
98Abnormal ciliary motility (HP:0012262)1.85116296
99Oligomenorrhea (HP:0000876)1.84815966
100Anencephaly (HP:0002323)1.84610267
101Severe visual impairment (HP:0001141)1.84344122
102Lissencephaly (HP:0001339)1.82984349
103Cerebellar dysplasia (HP:0007033)1.81766474
104Narrow forehead (HP:0000341)1.81524733
105Insulin-resistant diabetes mellitus (HP:0000831)1.81359994
106Abnormality of the renal cortex (HP:0011035)1.80928674
107Ketoacidosis (HP:0001993)1.79862559
108Occipital encephalocele (HP:0002085)1.79688994
109Abnormality of the labia minora (HP:0012880)1.79542854
110Mitochondrial inheritance (HP:0001427)1.79508617
111Spastic gait (HP:0002064)1.78806577
112Male pseudohermaphroditism (HP:0000037)1.78544242
113Furrowed tongue (HP:0000221)1.78120720
114Acute necrotizing encephalopathy (HP:0006965)1.78091312
115True hermaphroditism (HP:0010459)1.77514974
116Genetic anticipation (HP:0003743)1.77246222
117Oligodactyly (HP:0012165)1.76994736
118Type II diabetes mellitus (HP:0005978)1.76479909
119Decreased central vision (HP:0007663)1.76419073
120Methylmalonic acidemia (HP:0002912)1.75981274
121Congenital glaucoma (HP:0001087)1.75869203
122Short foot (HP:0001773)1.75823816
123Abnormal respiratory epithelium morphology (HP:0012253)1.75584190
124Abnormal respiratory motile cilium morphology (HP:0005938)1.75584190
125Blue irides (HP:0000635)1.74478553
126Muscular hypotonia of the trunk (HP:0008936)1.74353173
127Osteomalacia (HP:0002749)1.74164790
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.73860481
129Lipid accumulation in hepatocytes (HP:0006561)1.73226466
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72748637
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.72748637
132Atelectasis (HP:0100750)1.72184253
133Prominent nasal bridge (HP:0000426)1.71655198
134Acute encephalopathy (HP:0006846)1.71628642
135Left ventricular hypertrophy (HP:0001712)1.71053192
136Prominent supraorbital ridges (HP:0000336)1.70027629
137Hypomagnesemia (HP:0002917)1.69879054
138Morphological abnormality of the middle ear (HP:0008609)1.69811276
139Polydipsia (HP:0001959)1.69436667
140Abnormal drinking behavior (HP:0030082)1.69436667
141Broad foot (HP:0001769)1.69025523
142Abnormality of the fovea (HP:0000493)1.68983441
143Decreased testicular size (HP:0008734)1.68927845
144Poor suck (HP:0002033)1.68844089
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68783812
146Menstrual irregularities (HP:0000858)1.68205094
147Impaired vibration sensation in the lower limbs (HP:0002166)1.67064597
148Restlessness (HP:0000711)1.66777238
149Increased hepatocellular lipid droplets (HP:0006565)1.66199671
150Abolished electroretinogram (ERG) (HP:0000550)1.65935183
151Type II lissencephaly (HP:0007260)1.65658602
152Preaxial hand polydactyly (HP:0001177)1.65221635
153Abnormality of salivation (HP:0100755)1.65037801
154Abnormality of the metopic suture (HP:0005556)1.64618843
155Abnormality of midbrain morphology (HP:0002418)1.64550890
156Abnormal respiratory motile cilium physiology (HP:0012261)1.64513200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.19469834
2NTRK33.54187619
3CASK3.00499164
4INSRR2.94865612
5MAP3K42.51706868
6MAP2K72.43077470
7UHMK12.42527969
8WNK32.39972030
9NTRK22.23273664
10MAPK132.17928360
11MAP3K92.17916217
12ERBB31.98912850
13MINK11.95772611
14PNCK1.93138116
15GRK11.85649512
16SIK31.83842220
17EPHA41.82773596
18KSR11.82579050
19MAP3K121.71765466
20PAK61.64498976
21TNIK1.62507050
22MAP4K21.61619977
23AKT31.59731007
24PRKD31.59120335
25PINK11.48933915
26MAP3K21.48154807
27ACVR1B1.47982156
28BCR1.47260741
29EPHA31.45713569
30IRAK21.44818374
31BMPR1B1.43635518
32MAPK151.42159282
33DYRK21.38936277
34NTRK11.35337155
35MAP2K41.32568185
36PAK31.29669828
37SIK21.26292043
38EPHB21.25205289
39MKNK21.21903824
40CSNK1G21.21226308
41DAPK21.21051033
42TRIM281.19466721
43CDK51.18088971
44HIPK21.17364869
45DYRK1A1.14437456
46GRK51.11205334
47SGK2231.09888136
48SGK4941.09888136
49CAMK1G1.09253879
50PASK1.08472286
51STK38L1.08352732
52CSNK1G31.06407838
53CAMKK21.05344683
54PRKCG0.98989025
55TAF10.96777201
56PHKG10.94653115
57PHKG20.94653115
58BRD40.90924986
59CSNK1A1L0.90390574
60PLK20.88872075
61SGK20.88343491
62WNK40.88162433
63BMPR20.87329237
64NUAK10.84265893
65DYRK30.82943158
66STK240.81906277
67STK390.81531592
68CDC42BPA0.81092842
69FER0.80024965
70CAMK2A0.79119469
71PRKCE0.78630516
72CDK180.77664039
73CDK190.75817212
74ZAK0.74786328
75CSNK1G10.73547824
76WEE10.72891202
77MKNK10.72865631
78CDK140.71959012
79CAMK2B0.71166018
80FES0.69383186
81ADRBK10.69015358
82CDK150.67875274
83GRK70.66327513
84FRK0.61956394
85TSSK60.60804494
86MARK20.59789138
87CDK11A0.59692139
88FGFR20.59255078
89PKN10.57484036
90PRPF4B0.55637776
91RET0.54804030
92CAMK10.54458063
93ADRBK20.54417670
94NME10.54343757
95CAMKK10.53438834
96SGK10.53127365
97RPS6KA20.51971944
98CAMK2D0.51913095
99SRPK10.51749102
100BRAF0.51021598
101TLK10.50201242
102PLK30.50183271
103PDGFRA0.49902962
104PRKCZ0.49742562
105TYRO30.49575872
106IRAK10.49529566
107PRKCH0.49483348
108DAPK10.49412474
109CDK30.47285631
110NEK60.47128162
111CSNK1A10.47068129
112CSNK1D0.46976218
113CSNK1E0.46629348
114STK110.46430173
115VRK10.46426287
116ERBB20.45030860
117PRKACA0.44842548
118TGFBR10.44758423
119WNK10.44169559
120PRKG10.41802154
121STK30.40859539
122PRKAA10.39305128
123CAMK40.38961971
124PRKCB0.37694849
125NLK0.37400765
126TAOK30.37395794
127OBSCN0.37385791
128SGK30.37114893
129RPS6KB10.37018269
130MAP2K60.36643525
131PRKACB0.36259019
132OXSR10.35758947
133CAMK1D0.35049687
134PRKACG0.34673157
135RPS6KA30.34153841
136PRKCI0.31059242
137ROCK10.30569891
138BCKDK0.29202399

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.68965065
2Nicotine addiction_Homo sapiens_hsa050333.38913362
3Synaptic vesicle cycle_Homo sapiens_hsa047212.96125037
4Insulin secretion_Homo sapiens_hsa049112.82376149
5GABAergic synapse_Homo sapiens_hsa047272.52204190
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40376177
7Circadian entrainment_Homo sapiens_hsa047132.29268919
8Cocaine addiction_Homo sapiens_hsa050302.28535669
9Phototransduction_Homo sapiens_hsa047442.26914794
10Amphetamine addiction_Homo sapiens_hsa050312.26354932
11Morphine addiction_Homo sapiens_hsa050322.17588464
12Dopaminergic synapse_Homo sapiens_hsa047282.11170410
13Taste transduction_Homo sapiens_hsa047422.09162973
14Glutamatergic synapse_Homo sapiens_hsa047242.03416271
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01146459
16Serotonergic synapse_Homo sapiens_hsa047261.92501337
17Olfactory transduction_Homo sapiens_hsa047401.89257864
18Long-term potentiation_Homo sapiens_hsa047201.87831061
19Vibrio cholerae infection_Homo sapiens_hsa051101.80806808
20Collecting duct acid secretion_Homo sapiens_hsa049661.79004309
21Cholinergic synapse_Homo sapiens_hsa047251.77508967
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74564764
23Protein export_Homo sapiens_hsa030601.71170199
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63702681
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63081541
26Nitrogen metabolism_Homo sapiens_hsa009101.61636127
27Type II diabetes mellitus_Homo sapiens_hsa049301.58690794
28Steroid biosynthesis_Homo sapiens_hsa001001.54290866
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52363627
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51556948
31Renin secretion_Homo sapiens_hsa049241.48895393
32Oxidative phosphorylation_Homo sapiens_hsa001901.42686153
33Axon guidance_Homo sapiens_hsa043601.37987303
34Long-term depression_Homo sapiens_hsa047301.37150719
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34703385
36Propanoate metabolism_Homo sapiens_hsa006401.33788497
37Circadian rhythm_Homo sapiens_hsa047101.32944106
38Salivary secretion_Homo sapiens_hsa049701.28767068
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28696766
40Sulfur metabolism_Homo sapiens_hsa009201.24183899
41Cardiac muscle contraction_Homo sapiens_hsa042601.23732636
42Basal transcription factors_Homo sapiens_hsa030221.19819254
43Gap junction_Homo sapiens_hsa045401.19512593
44Ether lipid metabolism_Homo sapiens_hsa005651.18510769
45Linoleic acid metabolism_Homo sapiens_hsa005911.16943226
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15603020
47Alzheimers disease_Homo sapiens_hsa050101.14951163
48Tryptophan metabolism_Homo sapiens_hsa003801.12489711
49Parkinsons disease_Homo sapiens_hsa050121.11440910
50Gastric acid secretion_Homo sapiens_hsa049711.10769572
51Type I diabetes mellitus_Homo sapiens_hsa049401.09709476
52Oxytocin signaling pathway_Homo sapiens_hsa049211.09417672
53Calcium signaling pathway_Homo sapiens_hsa040201.06560370
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99837514
55Melanogenesis_Homo sapiens_hsa049160.99390503
56cAMP signaling pathway_Homo sapiens_hsa040240.97668853
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92976510
58Alcoholism_Homo sapiens_hsa050340.92976171
59Estrogen signaling pathway_Homo sapiens_hsa049150.91307019
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.90476703
61GnRH signaling pathway_Homo sapiens_hsa049120.90287150
62Pancreatic secretion_Homo sapiens_hsa049720.90175048
63Peroxisome_Homo sapiens_hsa041460.89664934
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89595446
65Vitamin B6 metabolism_Homo sapiens_hsa007500.89004445
66Huntingtons disease_Homo sapiens_hsa050160.87360266
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87162142
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83712697
69ErbB signaling pathway_Homo sapiens_hsa040120.82263786
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82249210
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79954303
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79867131
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78611457
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77435070
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76832016
76Thyroid hormone synthesis_Homo sapiens_hsa049180.76182573
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.75653938
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75199972
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73730154
80Selenocompound metabolism_Homo sapiens_hsa004500.72643443
81beta-Alanine metabolism_Homo sapiens_hsa004100.71277725
82Glucagon signaling pathway_Homo sapiens_hsa049220.71045170
83Folate biosynthesis_Homo sapiens_hsa007900.70220834
84Hedgehog signaling pathway_Homo sapiens_hsa043400.69577093
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69338455
86* Wnt signaling pathway_Homo sapiens_hsa043100.67547920
87Fanconi anemia pathway_Homo sapiens_hsa034600.66856812
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64877943
89Caffeine metabolism_Homo sapiens_hsa002320.64648714
90Hippo signaling pathway_Homo sapiens_hsa043900.63733619
91Dilated cardiomyopathy_Homo sapiens_hsa054140.62882208
92Endometrial cancer_Homo sapiens_hsa052130.61387679
93Glioma_Homo sapiens_hsa052140.60247892
94N-Glycan biosynthesis_Homo sapiens_hsa005100.60137640
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59713446
96ABC transporters_Homo sapiens_hsa020100.59555457
97Regulation of autophagy_Homo sapiens_hsa041400.59427460
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.58275327
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57947656
100RNA degradation_Homo sapiens_hsa030180.57696522
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56722379
102Mineral absorption_Homo sapiens_hsa049780.55061774
103Renal cell carcinoma_Homo sapiens_hsa052110.52755529
104MAPK signaling pathway_Homo sapiens_hsa040100.52505020
105Chemical carcinogenesis_Homo sapiens_hsa052040.52085392
106Oocyte meiosis_Homo sapiens_hsa041140.51573386
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51018198
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50759507
109Retinol metabolism_Homo sapiens_hsa008300.50638284
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50312912
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50088063
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46759290
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46581280
114Fatty acid metabolism_Homo sapiens_hsa012120.45633417
115Fatty acid elongation_Homo sapiens_hsa000620.45551772
116Basal cell carcinoma_Homo sapiens_hsa052170.45456199
117Metabolic pathways_Homo sapiens_hsa011000.45299030
118Choline metabolism in cancer_Homo sapiens_hsa052310.43458284
119Ras signaling pathway_Homo sapiens_hsa040140.43365320
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42926752
121Colorectal cancer_Homo sapiens_hsa052100.42473269
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41937180
123Insulin signaling pathway_Homo sapiens_hsa049100.41841645
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40340079
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39864501
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39857302
127Dorso-ventral axis formation_Homo sapiens_hsa043200.39644486
128Prion diseases_Homo sapiens_hsa050200.38639274
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38477739
130Histidine metabolism_Homo sapiens_hsa003400.37467957
131TGF-beta signaling pathway_Homo sapiens_hsa043500.37237055
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36989434
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35638617
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.34733493
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34474028
136Inositol phosphate metabolism_Homo sapiens_hsa005620.34124941
137Ovarian steroidogenesis_Homo sapiens_hsa049130.33810941
138Prolactin signaling pathway_Homo sapiens_hsa049170.33363532
139Butanoate metabolism_Homo sapiens_hsa006500.33180345
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.33163576
141Phagosome_Homo sapiens_hsa041450.32947744

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