CXXC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.60676235
2NIK/NF-kappaB signaling (GO:0038061)4.40270014
3positive regulation by symbiont of host defense response (GO:0052509)4.07258073
4modulation by symbiont of host defense response (GO:0052031)4.07258073
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07258073
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07258073
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.07258073
8modulation by symbiont of host immune response (GO:0052553)4.07258073
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.95158580
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.90070965
11detection of bacterium (GO:0016045)3.83557945
12positive regulation of B cell differentiation (GO:0045579)3.79459000
13mucosal-associated lymphoid tissue development (GO:0048537)3.75395778
14Peyers patch development (GO:0048541)3.75395778
15regulation of gamma-delta T cell differentiation (GO:0045586)3.73813091
16protein localization to kinetochore (GO:0034501)3.69042269
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61463811
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.61463811
19negative regulation of RNA splicing (GO:0033119)3.59395424
20detection of other organism (GO:0098543)3.57795387
21regulation of translational fidelity (GO:0006450)3.56472735
22formation of translation preinitiation complex (GO:0001731)3.50373291
23protein localization to chromosome, centromeric region (GO:0071459)3.47307830
24folic acid-containing compound biosynthetic process (GO:0009396)3.46158142
25negative regulation of mRNA metabolic process (GO:1903312)3.45970075
26response to muramyl dipeptide (GO:0032495)3.45027948
27nucleosome disassembly (GO:0006337)3.44761998
28protein-DNA complex disassembly (GO:0032986)3.44761998
29ribosomal small subunit assembly (GO:0000028)3.43898849
30viral transcription (GO:0019083)3.43472797
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38554216
32negative regulation of cell killing (GO:0031342)3.38554216
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.38047113
34positive regulation of gamma-delta T cell activation (GO:0046645)3.34555652
35positive thymic T cell selection (GO:0045059)3.29774995
36immunoglobulin mediated immune response (GO:0016064)3.28971335
37mitotic nuclear envelope disassembly (GO:0007077)3.28127521
38regulation of interferon-beta biosynthetic process (GO:0045357)3.28033893
39B cell receptor signaling pathway (GO:0050853)3.26497729
40translational termination (GO:0006415)3.26362793
41negative regulation of mRNA processing (GO:0050686)3.26217718
42mannose metabolic process (GO:0006013)3.23265056
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.22003385
44maternal placenta development (GO:0001893)3.21426561
45regulation of gamma-delta T cell activation (GO:0046643)3.21257079
46intracellular estrogen receptor signaling pathway (GO:0030520)3.20505261
47negative regulation of histone methylation (GO:0031061)3.20249558
48regulation of monocyte differentiation (GO:0045655)3.20174878
49leukocyte aggregation (GO:0070486)3.19101011
50T cell selection (GO:0045058)3.16610978
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15207890
52macrophage activation involved in immune response (GO:0002281)3.14631856
53mitotic chromosome condensation (GO:0007076)3.13715761
54regulation of B cell receptor signaling pathway (GO:0050855)3.13592596
55regulation of type I interferon-mediated signaling pathway (GO:0060338)3.13276677
56positive regulation of histone deacetylation (GO:0031065)3.12452472
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12360742
58DNA strand elongation involved in DNA replication (GO:0006271)3.10884915
59translational elongation (GO:0006414)3.10655201
60peptidyl-lysine dimethylation (GO:0018027)3.10214186
61antigen processing and presentation of endogenous antigen (GO:0019883)3.09522956
62heterochromatin organization (GO:0070828)3.07893351
633-UTR-mediated mRNA stabilization (GO:0070935)3.06866139
64modulation by virus of host process (GO:0019054)3.04682144
65regulation of chromatin binding (GO:0035561)3.03712741
66regulation of B cell differentiation (GO:0045577)3.03602240
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02573597
68maturation of SSU-rRNA (GO:0030490)3.02256927
69response to peptidoglycan (GO:0032494)3.01557206
70membrane disassembly (GO:0030397)2.99278051
71nuclear envelope disassembly (GO:0051081)2.99278051
72thymic T cell selection (GO:0045061)2.98870248
73histone H3-K36 demethylation (GO:0070544)2.97100864
74pre-miRNA processing (GO:0031054)2.96806971
75DNA strand elongation (GO:0022616)2.96799246
76IMP biosynthetic process (GO:0006188)2.94939834
77cellular response to type I interferon (GO:0071357)2.94856153
78type I interferon signaling pathway (GO:0060337)2.94856153
79response to type I interferon (GO:0034340)2.93594076
80negative regulation of innate immune response (GO:0045824)2.92116744
81DNA duplex unwinding (GO:0032508)2.91979401
82positive T cell selection (GO:0043368)2.91759989
83response to host immune response (GO:0052572)2.91086923
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91086923
85translational initiation (GO:0006413)2.90796099
86regulation of superoxide anion generation (GO:0032928)2.88643910
87germinal center formation (GO:0002467)2.88173355
88negative thymic T cell selection (GO:0045060)2.86818860
89DNA geometric change (GO:0032392)2.86541397
90spliceosomal tri-snRNP complex assembly (GO:0000244)2.85698408
91nuclear pore complex assembly (GO:0051292)2.84726383
92antigen processing and presentation via MHC class Ib (GO:0002475)2.82486473
93neutrophil activation involved in immune response (GO:0002283)2.82361202
94negative regulation of erythrocyte differentiation (GO:0045647)2.81849217
95regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80944235
96nuclear pore organization (GO:0006999)2.79770007
97negative T cell selection (GO:0043383)2.79233788
98positive regulation of gene expression, epigenetic (GO:0045815)2.78010075
99RNA stabilization (GO:0043489)2.75755382
100mRNA stabilization (GO:0048255)2.75755382
101negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.75617923
102negative regulation of B cell apoptotic process (GO:0002903)2.74838473
103cellular response to interleukin-4 (GO:0071353)2.74300875
104response to host (GO:0075136)2.72508047
105response to host defenses (GO:0052200)2.72508047
106response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72508047
107dosage compensation (GO:0007549)2.71681916
108viral mRNA export from host cell nucleus (GO:0046784)2.71424838
109protein localization to chromosome (GO:0034502)2.70901896
110modulation by symbiont of host cellular process (GO:0044068)2.70619434
111regulation of histone H3-K9 methylation (GO:0051570)2.70389703
112gene silencing (GO:0016458)2.70294494
113negative regulation of leukocyte mediated immunity (GO:0002704)2.70190034
114T cell migration (GO:0072678)2.69970084
115negative regulation of phagocytosis (GO:0050765)2.67730239
116IMP metabolic process (GO:0046040)2.67404120
117regulation of antigen processing and presentation (GO:0002577)2.67369672
118endothelial tube morphogenesis (GO:0061154)2.66732865
119morphogenesis of an endothelium (GO:0003159)2.66732865
120histone H4 deacetylation (GO:0070933)2.65779769
121negative regulation of lymphocyte mediated immunity (GO:0002707)2.65092808
122regulation of RNA export from nucleus (GO:0046831)2.63674717
123mature B cell differentiation involved in immune response (GO:0002313)2.62743176
124positive regulation of antigen processing and presentation (GO:0002579)2.62285576
125pinocytosis (GO:0006907)2.62020340
126positive regulation of protein deacetylation (GO:0090312)2.60070638
127cellular extravasation (GO:0045123)2.59375037
128ncRNA 3-end processing (GO:0043628)2.59283531
129gene silencing by RNA (GO:0031047)2.58990591
130protein complex disassembly (GO:0043241)2.58885123
131detection of external biotic stimulus (GO:0098581)2.58487531
132B cell mediated immunity (GO:0019724)2.58439607
133natural killer cell differentiation (GO:0001779)2.57723339
134mitotic G1 DNA damage checkpoint (GO:0031571)2.57545451
135telomere maintenance via semi-conservative replication (GO:0032201)2.57057324
136tolerance induction (GO:0002507)2.57028728
137negative regulation of gene expression, epigenetic (GO:0045814)2.56913939
138activation of MAPKKK activity (GO:0000185)2.56749763
139B cell homeostasis (GO:0001782)2.56672183
140interferon-gamma-mediated signaling pathway (GO:0060333)2.56615095
141DNA replication initiation (GO:0006270)2.55927153
142viral life cycle (GO:0019058)2.53995210
143negative regulation of cell size (GO:0045792)2.53707454
144respiratory burst (GO:0045730)2.53661951
145SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53530516
146regulation of mast cell degranulation (GO:0043304)2.53209167
147response to interleukin-4 (GO:0070670)2.53082943
148regulation of interleukin-2 biosynthetic process (GO:0045076)2.52615841
149mRNA splicing, via spliceosome (GO:0000398)2.52327321
150RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.52327321
151negative regulation of myeloid cell apoptotic process (GO:0033033)2.52170963
152snRNA metabolic process (GO:0016073)2.51261975
153ribosomal small subunit biogenesis (GO:0042274)2.51021104
154negative regulation of interleukin-12 production (GO:0032695)2.50876441
155regulation of sister chromatid cohesion (GO:0007063)2.50648639
156positive regulation of granulocyte differentiation (GO:0030854)2.50052854
157positive regulation by host of viral transcription (GO:0043923)2.49960611
158chromatin silencing (GO:0006342)2.48913770
159peptidyl-arginine omega-N-methylation (GO:0035247)2.48823242
160regulation of leukocyte degranulation (GO:0043300)2.47999364
161nuclear-transcribed mRNA catabolic process (GO:0000956)2.47897613
162alternative mRNA splicing, via spliceosome (GO:0000380)2.47561919
163CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.47277952
164T cell apoptotic process (GO:0070231)2.47053120
165translesion synthesis (GO:0019985)2.46563240
166cellular hyperosmotic response (GO:0071474)2.46475885
167regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46414816
168nuclear envelope organization (GO:0006998)2.45947583
169RNA splicing, via transesterification reactions (GO:0000375)2.45890374
170protein targeting to ER (GO:0045047)2.45096146
171Arp2/3 complex-mediated actin nucleation (GO:0034314)2.44147928
172chromatin assembly (GO:0031497)2.44102422
173cellular protein complex disassembly (GO:0043624)2.42985498
174Golgi transport vesicle coating (GO:0048200)2.42172422
175COPI coating of Golgi vesicle (GO:0048205)2.42172422
176mitotic sister chromatid cohesion (GO:0007064)2.41244259
177DNA replication-dependent nucleosome assembly (GO:0006335)2.40833070
178DNA replication-dependent nucleosome organization (GO:0034723)2.40833070
179RNA catabolic process (GO:0006401)2.40383497
180response to interleukin-15 (GO:0070672)2.40219763
181cotranslational protein targeting to membrane (GO:0006613)2.40024571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88922946
2MYC_22102868_ChIP-Seq_BL_Human3.68991720
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.58238201
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34791299
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.97609900
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.52589953
7VDR_21846776_ChIP-Seq_THP-1_Human2.50837059
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36203208
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32102472
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18175840
11* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11375752
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11313714
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03521361
14TCF7_22412390_ChIP-Seq_EML_Mouse2.02414689
15* CIITA_25753668_ChIP-Seq_RAJI_Human2.01632457
16MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90375163
17KDM2B_26808549_Chip-Seq_DND41_Human1.80403223
18UTX_26944678_Chip-Seq_JUKART_Human1.79718928
19MAF_26560356_Chip-Seq_TH1_Human1.79457911
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77009972
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76547654
22XRN2_22483619_ChIP-Seq_HELA_Human1.71502033
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.67994264
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62952222
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.62735449
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61183498
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55525201
28TET1_21451524_ChIP-Seq_MESCs_Mouse1.55344966
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55107919
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54830736
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52425172
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50801033
33BCL6_27268052_Chip-Seq_Bcells_Human1.50795586
34BCOR_27268052_Chip-Seq_Bcells_Human1.50608566
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.50595631
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49375094
37* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47582670
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47182334
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47131864
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.45098852
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41129390
42PU.1_20513432_ChIP-Seq_Bcells_Mouse1.40958782
43* MAF_26560356_Chip-Seq_TH2_Human1.40779006
44PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38963729
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38569411
46* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37884292
47LXR_22292898_ChIP-Seq_THP-1_Human1.37754385
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37418162
49SCL_19346495_ChIP-Seq_HPC-7_Human1.36507196
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35049722
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33276851
52VDR_24763502_ChIP-Seq_THP-1_Human1.30772410
53KDM5A_27292631_Chip-Seq_BREAST_Human1.30631037
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30382260
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30368610
56* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30165225
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28675837
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28667220
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28309263
60* MYB_26560356_Chip-Seq_TH2_Human1.27151677
61* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26643378
62GABP_19822575_ChIP-Seq_HepG2_Human1.26260053
63SMC4_20622854_ChIP-Seq_HELA_Human1.26137258
64MYB_26560356_Chip-Seq_TH1_Human1.25920526
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25408002
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25161009
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24136909
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.22495546
69NCOR1_26117541_ChIP-Seq_K562_Human1.22177146
70* ETS1_20019798_ChIP-Seq_JURKAT_Human1.22096494
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21972763
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21739919
73FOXP3_21729870_ChIP-Seq_TREG_Human1.21094693
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20227015
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19983550
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19151587
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19109763
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.19086471
79PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17803628
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16884135
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.16123054
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16046489
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15912022
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15750157
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15458273
86AR_21909140_ChIP-Seq_LNCAP_Human1.15423732
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15261922
88RACK7_27058665_Chip-Seq_MCF-7_Human1.14410824
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14088487
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.13986301
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13722021
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13701831
93PHF8_20622854_ChIP-Seq_HELA_Human1.13560759
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13124731
95ZNF263_19887448_ChIP-Seq_K562_Human1.12881335
96* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12747306
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12366685
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.12033735
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11428926
100P68_20966046_ChIP-Seq_HELA_Human1.10534812
101* ATF3_27146783_Chip-Seq_COLON_Human1.10430598
102MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10195311
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08904664
104SPI1_23127762_ChIP-Seq_K562_Human1.08791039
105ETS1_21867929_ChIP-Seq_TH2_Mouse1.07509493
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07175831
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07055199
108CREB1_26743006_Chip-Seq_LNCaP_Human1.06952251
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06229439
110* DCP1A_22483619_ChIP-Seq_HELA_Human1.06058430
111PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06052616
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.05972592
113E2F1_20622854_ChIP-Seq_HELA_Human1.05889336
114KDM2B_26808549_Chip-Seq_K562_Human1.05850607
115CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05444193
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04621794
117VDR_23849224_ChIP-Seq_CD4+_Human1.03921260
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03715345
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.02817968
120NOTCH1_21737748_ChIP-Seq_TLL_Human1.02537030
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02501588
122* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02497559
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.02382175
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01982038
125* SPI1_23547873_ChIP-Seq_NB4_Human1.01789328
126* EST1_17652178_ChIP-ChIP_JURKAT_Human1.01753349
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00856773
128MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99590801
129* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98647716
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98475350
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96468211
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95341920
133CLOCK_20551151_ChIP-Seq_293T_Human0.95072073
134JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93603829
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93331439
136IRF8_22096565_ChIP-ChIP_GC-B_Human0.92751862
137CHD1_26751641_Chip-Seq_LNCaP_Human0.92351357
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92203188
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92137358
140CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91977975
141GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91374862
142ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90661030
143* TTF2_22483619_ChIP-Seq_HELA_Human0.90641668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching2.88062274
2MP0005058_abnormal_lysosome_morphology2.76025596
3MP0009278_abnormal_bone_marrow2.62412631
4MP0003111_abnormal_nucleus_morphology2.60272732
5MP0003705_abnormal_hypodermis_morpholog2.44012096
6MP0002396_abnormal_hematopoietic_system2.43784466
7MP0003724_increased_susceptibility_to2.43549362
8MP0003300_gastrointestinal_ulcer2.40995471
9MP0004957_abnormal_blastocyst_morpholog2.35338099
10MP0003763_abnormal_thymus_physiology2.34139623
11MP0010352_gastrointestinal_tract_polyps2.33151108
12MP0003077_abnormal_cell_cycle2.26448827
13MP0010094_abnormal_chromosome_stability2.25366247
14MP0008260_abnormal_autophagy2.24462997
15MP0002419_abnormal_innate_immunity2.22034250
16MP0003172_abnormal_lysosome_physiology2.16024272
17MP0003303_peritoneal_inflammation2.15993663
18MP0005451_abnormal_body_composition2.08237180
19MP0004808_abnormal_hematopoietic_stem2.01072913
20MP0009785_altered_susceptibility_to1.93592477
21MP0001730_embryonic_growth_arrest1.90261691
22MP0001545_abnormal_hematopoietic_system1.86148644
23MP0005397_hematopoietic_system_phenotyp1.86148644
24MP0003183_abnormal_peptide_metabolism1.85490920
25MP0000685_abnormal_immune_system1.78454090
26MP0002398_abnormal_bone_marrow1.73512255
27MP0000703_abnormal_thymus_morphology1.72233143
28MP0005076_abnormal_cell_differentiation1.71822782
29MP0009333_abnormal_splenocyte_physiolog1.69933392
30MP0002148_abnormal_hypersensitivity_rea1.68798790
31MP0005083_abnormal_biliary_tract1.65486794
32MP0001533_abnormal_skeleton_physiology1.63590558
33MP0001873_stomach_inflammation1.62682229
34MP0002722_abnormal_immune_system1.52307281
35MP0000350_abnormal_cell_proliferation1.51995010
36MP0008961_abnormal_basal_metabolism1.51125570
37MP0000689_abnormal_spleen_morphology1.48394705
38MP0008007_abnormal_cellular_replicative1.46077053
39MP0001800_abnormal_humoral_immune1.45906293
40MP0008877_abnormal_DNA_methylation1.42584884
41MP0006054_spinal_hemorrhage1.39237819
42MP0000490_abnormal_crypts_of1.38693838
43MP0005220_abnormal_exocrine_pancreas1.36847141
44MP0001672_abnormal_embryogenesis/_devel1.35994000
45MP0005380_embryogenesis_phenotype1.35994000
46MP0003984_embryonic_growth_retardation1.35837291
47MP0002088_abnormal_embryonic_growth/wei1.34955900
48MP0002019_abnormal_tumor_incidence1.34291216
49MP0010307_abnormal_tumor_latency1.32785882
50MP0002132_abnormal_respiratory_system1.31981367
51MP0008057_abnormal_DNA_replication1.31125951
52MP0004185_abnormal_adipocyte_glucose1.30997651
53MP0001697_abnormal_embryo_size1.30691862
54MP0001853_heart_inflammation1.30634467
55MP0002086_abnormal_extraembryonic_tissu1.28596024
56* MP0002080_prenatal_lethality1.28481054
57MP0002429_abnormal_blood_cell1.28271912
58MP0000716_abnormal_immune_system1.27877507
59MP0000465_gastrointestinal_hemorrhage1.27469081
60MP0005387_immune_system_phenotype1.26377731
61MP0001790_abnormal_immune_system1.26377731
62MP0001851_eye_inflammation1.24735900
63MP0004197_abnormal_fetal_growth/weight/1.21604849
64MP0010155_abnormal_intestine_physiology1.21317664
65MP0002405_respiratory_system_inflammati1.21207290
66MP0003566_abnormal_cell_adhesion1.21052578
67MP0002166_altered_tumor_susceptibility1.18664373
68MP0003283_abnormal_digestive_organ1.17658475
69MP0010030_abnormal_orbit_morphology1.16777267
70MP0009840_abnormal_foam_cell1.16323786
71MP0003191_abnormal_cellular_cholesterol1.14587865
72MP0002933_joint_inflammation1.13672906
73MP0003436_decreased_susceptibility_to1.13319826
74MP0000313_abnormal_cell_death1.12176172
75MP0008469_abnormal_protein_level1.12128658
76MP0002420_abnormal_adaptive_immunity1.11516078
77MP0003252_abnormal_bile_duct1.11009780
78MP0005365_abnormal_bile_salt1.10633821
79* MP0002085_abnormal_embryonic_tissue1.08688464
80MP0001348_abnormal_lacrimal_gland1.08345697
81MP0001819_abnormal_immune_cell1.07638341
82MP0001915_intracranial_hemorrhage1.07142541
83MP0004510_myositis1.06983268
84MP0002452_abnormal_antigen_presenting1.06797406
85MP0006082_CNS_inflammation1.06608787
86MP0005023_abnormal_wound_healing1.06077843
87* MP0002084_abnormal_developmental_patter1.05151800
88MP0004947_skin_inflammation1.03770772
89MP0009672_abnormal_birth_weight1.02615394
90MP0002723_abnormal_immune_serum1.00066303
91MP0005666_abnormal_adipose_tissue0.99761148
92MP0005670_abnormal_white_adipose0.99697766
93MP0000003_abnormal_adipose_tissue0.98166338
94MP0002138_abnormal_hepatobiliary_system0.98143023
95MP0001849_ear_inflammation0.97305682
96MP0004264_abnormal_extraembryonic_tissu0.97036253
97MP0000858_altered_metastatic_potential0.96981741
98MP0005671_abnormal_response_to0.96866378
99MP0004381_abnormal_hair_follicle0.96743484
100MP0000598_abnormal_liver_morphology0.95935937
101MP0003656_abnormal_erythrocyte_physiolo0.95180356
102MP0002998_abnormal_bone_remodeling0.94783241
103MP0005310_abnormal_salivary_gland0.94344461
104MP0005464_abnormal_platelet_physiology0.93976446
105MP0008058_abnormal_DNA_repair0.93079066
106MP0003123_paternal_imprinting0.92749851
107MP0000733_abnormal_muscle_development0.92213108
108MP0000678_abnormal_parathyroid_gland0.89716474
109MP0001666_abnormal_nutrient_absorption0.89443526
110MP0000609_abnormal_liver_physiology0.89332460
111MP0003075_altered_response_to0.88927839
112MP0005375_adipose_tissue_phenotype0.87775815
113MP0010630_abnormal_cardiac_muscle0.87738798
114MP0003453_abnormal_keratinocyte_physiol0.82543605
115MP0003866_abnormal_defecation0.82376489
116MP0001845_abnormal_inflammatory_respons0.82366609
117MP0005621_abnormal_cell_physiology0.82344995
118MP0002653_abnormal_ependyma_morphology0.82066221
119MP0005360_urolithiasis0.81877874
120MP0008995_early_reproductive_senescence0.81077232
121MP0010368_abnormal_lymphatic_system0.80520109
122MP0004858_abnormal_nervous_system0.80289019
123MP0003567_abnormal_fetal_cardiomyocyte0.80275850
124MP0000477_abnormal_intestine_morphology0.80160362
125MP0008874_decreased_physiological_sensi0.80061567
126MP0005025_abnormal_response_to0.79411139
127MP0002925_abnormal_cardiovascular_devel0.77365926
128MP0009931_abnormal_skin_appearance0.77060727
129MP0005390_skeleton_phenotype0.76974083
130MP0003115_abnormal_respiratory_system0.76565332
131MP0000604_amyloidosis0.75250203
132MP0002139_abnormal_hepatobiliary_system0.74619114
133MP0005000_abnormal_immune_tolerance0.74036075
134MP0003119_abnormal_digestive_system0.73715373
135MP0002089_abnormal_postnatal_growth/wei0.73021851
136MP0001835_abnormal_antigen_presentation0.72910962
137MP0003091_abnormal_cell_migration0.72813399
138MP0003329_amyloid_beta_deposits0.72487242
139MP0005166_decreased_susceptibility_to0.68892072
140MP0003786_premature_aging0.67770509
141MP0005075_abnormal_melanosome_morpholog0.66291162
142MP0002877_abnormal_melanocyte_morpholog0.66182532
143MP0009763_increased_sensitivity_to0.64704765
144MP0001663_abnormal_digestive_system0.64243797
145MP0003806_abnormal_nucleotide_metabolis0.63823954

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.52756577
2Agammaglobulinemia (HP:0004432)3.75758147
3Abnormality of the fingertips (HP:0001211)3.69174903
4Recurrent abscess formation (HP:0002722)3.64269971
5Recurrent bacterial skin infections (HP:0005406)3.42703712
6Increased IgE level (HP:0003212)3.39132788
7Mediastinal lymphadenopathy (HP:0100721)3.37569249
8Meningitis (HP:0001287)3.34168250
9Nasal polyposis (HP:0100582)3.33965173
10Myositis (HP:0100614)3.26467356
11Elevated erythrocyte sedimentation rate (HP:0003565)3.24901431
12Abnormality of the nasal mucosa (HP:0000433)3.20551710
13Abnormality of macrophages (HP:0004311)3.08030544
14Chronic obstructive pulmonary disease (HP:0006510)3.03881558
15Obstructive lung disease (HP:0006536)3.03881558
16Hyperacusis (HP:0010780)3.03570902
17Gastrointestinal stroma tumor (HP:0100723)2.99243877
18Long eyelashes (HP:0000527)2.98016341
19Increased density of long bones (HP:0006392)2.97653115
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94824820
21Short 4th metacarpal (HP:0010044)2.94824820
22Hypertensive crisis (HP:0100735)2.89793095
23T lymphocytopenia (HP:0005403)2.87842821
24Combined immunodeficiency (HP:0005387)2.73489721
25Rectal prolapse (HP:0002035)2.65207904
26Abnormality of T cell number (HP:0011839)2.62565886
27Cerebral aneurysm (HP:0004944)2.62060205
28Abnormality of cells of the erythroid lineage (HP:0012130)2.60911631
29Selective tooth agenesis (HP:0001592)2.60822772
30Recurrent gram-negative bacterial infections (HP:0005420)2.58665667
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.52090282
32Increased cerebral lipofuscin (HP:0011813)2.50624022
33Colon cancer (HP:0003003)2.49102567
34Abnormal number of erythroid precursors (HP:0012131)2.49059859
35Dysostosis multiplex (HP:0000943)2.49038091
36Petechiae (HP:0000967)2.44514862
37Basal cell carcinoma (HP:0002671)2.44423281
38Severe combined immunodeficiency (HP:0004430)2.43516802
39Abnormality of the 4th metacarpal (HP:0010012)2.42269772
40Reticulocytopenia (HP:0001896)2.42269113
41Granulocytopenia (HP:0001913)2.41795614
42Osteomyelitis (HP:0002754)2.41666143
43Hepatosplenomegaly (HP:0001433)2.40579690
44Polygenic inheritance (HP:0010982)2.38959721
45Emphysema (HP:0002097)2.38515749
46Gingivitis (HP:0000230)2.38438152
47IgM deficiency (HP:0002850)2.38003888
48Bicuspid aortic valve (HP:0001647)2.37400249
49Recurrent bronchitis (HP:0002837)2.36519377
50Vasculitis (HP:0002633)2.36060555
51Gastrointestinal inflammation (HP:0004386)2.34435825
52Systemic lupus erythematosus (HP:0002725)2.33978465
53Papilloma (HP:0012740)2.33743372
54Verrucae (HP:0200043)2.33743372
55Ependymoma (HP:0002888)2.32143799
56Urticaria (HP:0001025)2.30052497
57Recurrent viral infections (HP:0004429)2.30040750
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.28944852
59Thrombocytosis (HP:0001894)2.28771146
60Abnormality of T cells (HP:0002843)2.26576254
61Increased serum ferritin (HP:0003281)2.25680038
62Recurrent skin infections (HP:0001581)2.25429274
63Gastrointestinal infarctions (HP:0005244)2.25338742
64Orchitis (HP:0100796)2.25130080
65Hypergammaglobulinemia (HP:0010702)2.23806976
66Cellulitis (HP:0100658)2.23560574
67Loss of speech (HP:0002371)2.22689173
68Shallow orbits (HP:0000586)2.22159502
69High pitched voice (HP:0001620)2.21339445
70Sepsis (HP:0100806)2.17654084
71Progressive external ophthalmoplegia (HP:0000590)2.17640729
72Increased nuchal translucency (HP:0010880)2.17004123
73Chest pain (HP:0100749)2.16237861
74Stomatitis (HP:0010280)2.15664672
75Multiple enchondromatosis (HP:0005701)2.12775003
76Recurrent cutaneous fungal infections (HP:0011370)2.12660555
77Chronic mucocutaneous candidiasis (HP:0002728)2.12660555
78Pustule (HP:0200039)2.12214761
79Broad face (HP:0000283)2.10392446
80Centrally nucleated skeletal muscle fibers (HP:0003687)2.07592583
81Skin tags (HP:0010609)2.07370229
82Hypertriglyceridemia (HP:0002155)2.05812628
83Inflammation of the large intestine (HP:0002037)2.04400736
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02836267
85Obstructive sleep apnea (HP:0002870)2.01397931
86Proximal placement of thumb (HP:0009623)2.01329241
87Metaphyseal cupping (HP:0003021)2.01117108
88Facial hemangioma (HP:0000329)2.00883646
89Purpura (HP:0000979)2.00315448
90Restrictive lung disease (HP:0002091)1.99016536
91Encephalitis (HP:0002383)1.98978311
92Epistaxis (HP:0000421)1.98678896
93Trigonocephaly (HP:0000243)1.98414834
94Thoracic kyphosis (HP:0002942)1.98347084
95Polycythemia (HP:0001901)1.98125939
96Distal lower limb amyotrophy (HP:0008944)1.98027594
97Recurrent lower respiratory tract infections (HP:0002783)1.97766081
98Abnormality of liposaccharide metabolism (HP:0010968)1.97086220
99Abnormality of glycosphingolipid metabolism (HP:0004343)1.97086220
100Abnormality of glycolipid metabolism (HP:0010969)1.97086220
101Hemorrhage of the eye (HP:0011885)1.96931050
102Colitis (HP:0002583)1.95413626
103Panhypogammaglobulinemia (HP:0003139)1.94677329
104Seborrheic dermatitis (HP:0001051)1.94632730
105Renal duplication (HP:0000075)1.94402586
106Short 1st metacarpal (HP:0010034)1.94260909
107Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.94260909
108Skin ulcer (HP:0200042)1.93577031
109Gastrointestinal dysmotility (HP:0002579)1.93108931
110Impaired platelet aggregation (HP:0003540)1.92877868
111Abnormal platelet function (HP:0011869)1.92877868
112Abnormal gallbladder physiology (HP:0012438)1.92689502
113Cholecystitis (HP:0001082)1.92689502
114Cutis marmorata (HP:0000965)1.92401395
115Recurrent sinusitis (HP:0011108)1.91719088
116Microretrognathia (HP:0000308)1.91492355
117Slow saccadic eye movements (HP:0000514)1.91471629
118Prominent nose (HP:0000448)1.90163900
119Elfin facies (HP:0004428)1.88857087
120Short phalanx of the thumb (HP:0009660)1.88041219
121Deviation of the thumb (HP:0009603)1.87975304
122Difficulty climbing stairs (HP:0003551)1.87178559
123Medulloblastoma (HP:0002885)1.86977649
124Pulmonary infiltrates (HP:0002113)1.86421174
125Interstitial pulmonary disease (HP:0006530)1.85985495
126Abnormality of reticulocytes (HP:0004312)1.85896819
127Malnutrition (HP:0004395)1.85749631
128Chronic otitis media (HP:0000389)1.85594318
129Optic neuritis (HP:0100653)1.84432236
130Retrobulbar optic neuritis (HP:0100654)1.84432236
131Broad palm (HP:0001169)1.83290182
132Arterial thrombosis (HP:0004420)1.82989551
133Recurrent fungal infections (HP:0002841)1.82980999
134Peripheral hypomyelination (HP:0007182)1.82817598
135Hand muscle atrophy (HP:0009130)1.82036757
136Myopathic facies (HP:0002058)1.82017624
137Hemoptysis (HP:0002105)1.81969077
138Biconcave vertebral bodies (HP:0004586)1.80448398
139Thyroiditis (HP:0100646)1.80253940
140Protrusio acetabuli (HP:0003179)1.79558805
141Long palpebral fissure (HP:0000637)1.79123442
142Abnormality of the thoracic spine (HP:0100711)1.78978034
143Preauricular skin tag (HP:0000384)1.78948591
144Ragged-red muscle fibers (HP:0003200)1.78903352
145Renovascular hypertension (HP:0100817)1.78669215
146Recurrent pneumonia (HP:0006532)1.78663122
147Abnormal number of incisors (HP:0011064)1.78495374
148Reticulocytosis (HP:0001923)1.77963760
149Spontaneous hematomas (HP:0007420)1.74151419
150Mitral valve prolapse (HP:0001634)1.72353291
151Autoimmune thrombocytopenia (HP:0001973)1.72275687
152Insomnia (HP:0100785)1.71940477
153Abnormality of the pancreatic islet cells (HP:0006476)1.71146539
154Abnormality of endocrine pancreas physiology (HP:0012093)1.71146539
155Abnormality of cells of the lymphoid lineage (HP:0012140)1.70408458
156Abnormality of the peritoneum (HP:0002585)1.68980387
157Deep venous thrombosis (HP:0002625)1.68711802
158Aplastic anemia (HP:0001915)1.67108657
159Abnormality of the metopic suture (HP:0005556)1.66308547
160Prolonged bleeding time (HP:0003010)1.65223648
161Progressive muscle weakness (HP:0003323)1.64707721
162Short palpebral fissure (HP:0012745)1.64535313
163Aortic aneurysm (HP:0004942)1.64292197
164Ulnar bowing (HP:0003031)1.63929165
165Lymphopenia (HP:0001888)1.63898432
166Trismus (HP:0000211)1.63615979
167Atresia of the external auditory canal (HP:0000413)1.63308648
168Fatigue (HP:0012378)1.62601217
169Late onset (HP:0003584)1.60821252
170Spastic diplegia (HP:0001264)1.60465379
171Mesangial abnormality (HP:0001966)1.60424501
172Ectopic kidney (HP:0000086)1.59993023
173Ureteral stenosis (HP:0000071)1.59848421
174Abnormality of the 1st metacarpal (HP:0010009)1.59527398
175Distal upper limb amyotrophy (HP:0007149)1.58552809
176Upper limb amyotrophy (HP:0009129)1.58552809
177Cerebellar dysplasia (HP:0007033)1.58034977
178Bronchitis (HP:0012387)1.58025588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.98516593
2TRIB33.83240369
3EEF2K3.72044701
4PKN23.40450277
5PRPF4B3.37980729
6SMG13.24584826
7MAP4K13.10587044
8CDK122.80499128
9ERN12.73912147
10RIPK42.45844114
11NEK22.21842805
12BRD42.14774808
13CDC71.99131684
14STK101.93754029
15MAP3K131.85490422
16PASK1.82974434
17GRK61.79460862
18MAP3K141.71989557
19RPS6KA41.63551293
20TNK21.61615341
21LRRK21.60413955
22KDR1.59530568
23CDK41.59115641
24ZAP701.57280291
25PTK61.51150344
26FGFR41.43492446
27FES1.38046427
28IRAK41.37855011
29BLK1.37601747
30MAP3K31.33827978
31RPS6KB21.32899655
32MAP2K31.30300721
33ICK1.28710627
34SCYL21.28232643
35BCKDK1.25949987
36PAK41.22379147
37BUB11.17031538
38PIM11.16241418
39CDK91.15876586
40SIK31.14011222
41TTN1.11676247
42SIK11.09748020
43MAP3K81.08191021
44MTOR1.07377436
45MARK21.07149815
46TAOK11.02145280
47KIT1.00778385
48TESK20.99838088
49TAOK20.99681589
50CDK60.98708574
51IRAK30.95980077
52STK40.95255507
53FLT30.94672696
54FGR0.94392886
55TYK20.94379724
56BTK0.93847555
57JAK30.91336953
58TGFBR10.90712990
59CDK70.89313327
60RIPK10.89139342
61PRKD20.88451145
62MAP3K10.88173196
63ALK0.86658088
64ITK0.86587893
65WEE10.86246714
66IKBKB0.85467116
67CHUK0.84042514
68VRK20.79074498
69DYRK1B0.78496216
70MAP3K70.78140879
71LYN0.76949102
72CDC42BPA0.76380632
73MAPK150.75995593
74AURKB0.72648244
75ARAF0.72387352
76TGFBR20.71516586
77CHEK10.71484116
78MAPKAPK30.70913604
79MAPK120.70793661
80EIF2AK10.70214876
81MATK0.70171183
82PDGFRA0.69807614
83RPS6KL10.69604366
84RPS6KC10.69604366
85DYRK30.69513987
86ATR0.69217495
87MAP2K20.67755035
88MAP3K60.66957456
89MAPK110.66892924
90BMX0.66783857
91PRKCH0.66223994
92PDPK10.65732088
93CSK0.65392968
94NEK10.64476562
95EPHB10.63006898
96FGFR30.62940295
97NLK0.62300475
98TTK0.62119636
99TBK10.61471213
100SIK20.60037658
101JAK10.59665529
102PDK10.58870290
103MARK30.57999494
104TAOK30.57965478
105PAK20.57916288
106PLK10.57847006
107PIM20.57585625
108TYRO30.54893714
109CAMK1G0.54736531
110CDK20.54319362
111RPS6KA10.53331706
112CAMK1D0.53204319
113MAPK70.52185866
114JAK20.51603831
115CSF1R0.51576092
116RPS6KA20.51525037
117DAPK10.51418210
118PRKD30.50892675
119MAPKAPK20.50856964
120IKBKE0.48962841
121MAPK40.46559149
122CAMKK10.46034075
123HIPK20.45792181
124MAP3K110.45709773
125TESK10.45609883
126FGFR10.45316785
127NME20.45022977
128SYK0.44919636
129ILK0.43407890
130HCK0.41668219
131LCK0.39804471
132MAP2K60.38831623
133CCNB10.38689667
134KSR20.38112239
135ACVR1B0.38021645
136LATS10.37668727
137BRSK20.36602158
138MELK0.36395078
139RPS6KA60.35395676
140TXK0.34730942
141TSSK60.32857473

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.49372960
2Other glycan degradation_Homo sapiens_hsa005113.11965284
3Spliceosome_Homo sapiens_hsa030402.56648567
4Mismatch repair_Homo sapiens_hsa034302.37865792
5Base excision repair_Homo sapiens_hsa034102.36709961
6Primary immunodeficiency_Homo sapiens_hsa053402.36319168
7Allograft rejection_Homo sapiens_hsa053302.13849530
8RNA transport_Homo sapiens_hsa030132.12496589
9Ribosome_Homo sapiens_hsa030101.98887420
10One carbon pool by folate_Homo sapiens_hsa006701.95485818
11Autoimmune thyroid disease_Homo sapiens_hsa053201.89865236
12Notch signaling pathway_Homo sapiens_hsa043301.87451644
13Graft-versus-host disease_Homo sapiens_hsa053321.86921519
14Cell cycle_Homo sapiens_hsa041101.80189213
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77799766
16Lysine degradation_Homo sapiens_hsa003101.71298478
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62058467
18Chronic myeloid leukemia_Homo sapiens_hsa052201.61152528
19mRNA surveillance pathway_Homo sapiens_hsa030151.58945332
20Staphylococcus aureus infection_Homo sapiens_hsa051501.58238624
21B cell receptor signaling pathway_Homo sapiens_hsa046621.57719222
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53814760
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49195866
24Acute myeloid leukemia_Homo sapiens_hsa052211.48398102
25Selenocompound metabolism_Homo sapiens_hsa004501.44869007
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39945490
27Type I diabetes mellitus_Homo sapiens_hsa049401.38392026
28Asthma_Homo sapiens_hsa053101.36227342
29Antigen processing and presentation_Homo sapiens_hsa046121.34176133
30Herpes simplex infection_Homo sapiens_hsa051681.28065525
31RNA degradation_Homo sapiens_hsa030181.27338349
32Sulfur relay system_Homo sapiens_hsa041221.26883788
33Tuberculosis_Homo sapiens_hsa051521.26240255
34T cell receptor signaling pathway_Homo sapiens_hsa046601.26029992
35HTLV-I infection_Homo sapiens_hsa051661.24493000
36Biosynthesis of amino acids_Homo sapiens_hsa012301.21483801
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20187493
38Small cell lung cancer_Homo sapiens_hsa052221.19778742
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16997863
40TNF signaling pathway_Homo sapiens_hsa046681.15788957
41p53 signaling pathway_Homo sapiens_hsa041151.13404700
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.12061555
43Viral carcinogenesis_Homo sapiens_hsa052031.11760412
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.11598918
45Fructose and mannose metabolism_Homo sapiens_hsa000511.11547969
46Epstein-Barr virus infection_Homo sapiens_hsa051691.08929912
47Colorectal cancer_Homo sapiens_hsa052101.08740498
48Hepatitis C_Homo sapiens_hsa051601.05376684
49Leishmaniasis_Homo sapiens_hsa051401.04456939
50mTOR signaling pathway_Homo sapiens_hsa041501.04114583
51Non-small cell lung cancer_Homo sapiens_hsa052231.03412187
52Nucleotide excision repair_Homo sapiens_hsa034201.02239217
53Viral myocarditis_Homo sapiens_hsa054160.99384439
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98118616
55Homologous recombination_Homo sapiens_hsa034400.98055339
56Measles_Homo sapiens_hsa051620.97251678
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96834109
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96087802
59Pancreatic cancer_Homo sapiens_hsa052120.95603298
60Lysosome_Homo sapiens_hsa041420.95542702
61Thyroid cancer_Homo sapiens_hsa052160.95474225
62Osteoclast differentiation_Homo sapiens_hsa043800.92687615
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.91030019
64Apoptosis_Homo sapiens_hsa042100.90852902
65Pyrimidine metabolism_Homo sapiens_hsa002400.90846204
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90742817
67MicroRNAs in cancer_Homo sapiens_hsa052060.89885638
68Chemokine signaling pathway_Homo sapiens_hsa040620.89458903
69VEGF signaling pathway_Homo sapiens_hsa043700.88677264
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88674891
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86672614
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.85912643
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.85574688
74Malaria_Homo sapiens_hsa051440.84965037
75Galactose metabolism_Homo sapiens_hsa000520.84939964
76Toxoplasmosis_Homo sapiens_hsa051450.84240132
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.83169842
78Insulin resistance_Homo sapiens_hsa049310.82764703
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82576146
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81651502
81Pentose phosphate pathway_Homo sapiens_hsa000300.81559759
82Fat digestion and absorption_Homo sapiens_hsa049750.81383868
83Bladder cancer_Homo sapiens_hsa052190.80915794
84Hepatitis B_Homo sapiens_hsa051610.80607304
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79857171
86Pertussis_Homo sapiens_hsa051330.79092479
87Prion diseases_Homo sapiens_hsa050200.77581634
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.74006776
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73765265
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73313957
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.73309707
92Legionellosis_Homo sapiens_hsa051340.73009086
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72512290
94Rheumatoid arthritis_Homo sapiens_hsa053230.72413430
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.72264012
96Influenza A_Homo sapiens_hsa051640.72063497
97Endometrial cancer_Homo sapiens_hsa052130.71972937
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71920810
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.71704083
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.70892012
101Folate biosynthesis_Homo sapiens_hsa007900.69005759
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68843055
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.68323751
104Shigellosis_Homo sapiens_hsa051310.67067856
105Endocytosis_Homo sapiens_hsa041440.66292739
106Carbon metabolism_Homo sapiens_hsa012000.65849947
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65846356
108Salmonella infection_Homo sapiens_hsa051320.64856532
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.64817775
110Platelet activation_Homo sapiens_hsa046110.63681970
111Choline metabolism in cancer_Homo sapiens_hsa052310.63535479
112Phagosome_Homo sapiens_hsa041450.63197226
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62312716
114N-Glycan biosynthesis_Homo sapiens_hsa005100.62020251
115Hematopoietic cell lineage_Homo sapiens_hsa046400.61063560
116Basal cell carcinoma_Homo sapiens_hsa052170.58714231
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57128825
118HIF-1 signaling pathway_Homo sapiens_hsa040660.56321232
119Non-homologous end-joining_Homo sapiens_hsa034500.56159031
120Prolactin signaling pathway_Homo sapiens_hsa049170.56112671
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55326761
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54942218
123Adherens junction_Homo sapiens_hsa045200.53668595
124GnRH signaling pathway_Homo sapiens_hsa049120.53078209
125Dorso-ventral axis formation_Homo sapiens_hsa043200.51084809
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50838219
127Systemic lupus erythematosus_Homo sapiens_hsa053220.50585605
128Nitrogen metabolism_Homo sapiens_hsa009100.50244683
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49929232
130Protein digestion and absorption_Homo sapiens_hsa049740.49256566
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.47339960
132Proteoglycans in cancer_Homo sapiens_hsa052050.47339474
133AMPK signaling pathway_Homo sapiens_hsa041520.46665590
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46381884
135Oocyte meiosis_Homo sapiens_hsa041140.46320583
136African trypanosomiasis_Homo sapiens_hsa051430.45846455
137Prostate cancer_Homo sapiens_hsa052150.45165854
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45134643
139Renal cell carcinoma_Homo sapiens_hsa052110.44569443
140Glioma_Homo sapiens_hsa052140.43987897
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43210716
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41808226

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