CXORF67

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.38128069
2regulation of meiosis I (GO:0060631)8.36878704
3regulation of acrosome reaction (GO:0060046)8.30373762
4meiotic cell cycle (GO:0051321)8.22188528
5DNA methylation involved in gamete generation (GO:0043046)7.99081399
6oocyte development (GO:0048599)7.55646040
7synapsis (GO:0007129)7.27913300
8female gamete generation (GO:0007292)7.00164801
9multicellular organism reproduction (GO:0032504)6.73831547
10regulation of histone H3-K9 methylation (GO:0051570)6.48628158
11mitotic chromosome condensation (GO:0007076)6.00070662
12gene silencing by RNA (GO:0031047)5.88370336
13positive regulation of histone H3-K4 methylation (GO:0051571)5.87353400
14chromosome organization involved in meiosis (GO:0070192)5.85414046
15glycine transport (GO:0015816)5.74225109
16synaptonemal complex assembly (GO:0007130)5.69024559
17retinal cone cell development (GO:0046549)5.68085492
18male meiosis I (GO:0007141)5.65391259
19protein kinase C signaling (GO:0070528)5.57292383
20negative regulation of reproductive process (GO:2000242)5.37500233
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24294855
22attachment of spindle microtubules to kinetochore (GO:0008608)5.21693755
23negative regulation of histone methylation (GO:0031061)5.02743847
24synaptonemal complex organization (GO:0070193)5.02165567
25positive regulation of humoral immune response (GO:0002922)4.97192740
26male meiosis (GO:0007140)4.87973289
27protein localization to chromosome, centromeric region (GO:0071459)4.84911832
28regulation of cell maturation (GO:1903429)4.74451602
29regulation of steroid hormone secretion (GO:2000831)4.72591554
30meiotic nuclear division (GO:0007126)4.67037353
31meiosis I (GO:0007127)4.67016325
32reproduction (GO:0000003)4.50048921
33protein localization to kinetochore (GO:0034501)4.40995306
34meiotic cell cycle process (GO:1903046)4.35806133
35regulation of meiosis (GO:0040020)4.32283689
36oogenesis (GO:0048477)4.31084838
37mitotic metaphase plate congression (GO:0007080)4.29275373
38L-amino acid import (GO:0043092)4.27102556
39binding of sperm to zona pellucida (GO:0007339)4.18698103
40positive regulation of gastrulation (GO:2000543)4.05190987
41fertilization (GO:0009566)4.04533348
42CENP-A containing nucleosome assembly (GO:0034080)4.04331622
43DNA methylation (GO:0006306)4.04181877
44DNA alkylation (GO:0006305)4.04181877
45positive regulation of reproductive process (GO:2000243)3.96623593
46sister chromatid cohesion (GO:0007062)3.95949258
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.91638760
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.91638760
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.91638760
50positive regulation of histone methylation (GO:0031062)3.89986058
51regulation of meiotic cell cycle (GO:0051445)3.87978623
52positive regulation of chromosome segregation (GO:0051984)3.83334410
53protein localization to chromosome (GO:0034502)3.80132867
54gene silencing (GO:0016458)3.79865941
55translesion synthesis (GO:0019985)3.78929009
56centriole replication (GO:0007099)3.72550395
57positive regulation of meiosis (GO:0045836)3.71413651
58regulation of spindle organization (GO:0090224)3.71314434
59regulation of histone H3-K4 methylation (GO:0051569)3.71097748
60histone H3-K9 demethylation (GO:0033169)3.69947099
61chromatin remodeling at centromere (GO:0031055)3.68162416
62establishment of chromosome localization (GO:0051303)3.56777299
63regulation of histone methylation (GO:0031060)3.56596973
64positive regulation of uterine smooth muscle contraction (GO:0070474)3.55055482
65phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.50185429
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48320728
67metaphase plate congression (GO:0051310)3.46923080
68positive regulation of meiotic cell cycle (GO:0051446)3.45152443
69primitive streak formation (GO:0090009)3.44793454
70regulation of steroid hormone biosynthetic process (GO:0090030)3.43715574
71labyrinthine layer development (GO:0060711)3.42270862
72phosphorelay signal transduction system (GO:0000160)3.39273009
73interkinetic nuclear migration (GO:0022027)3.39263322
74chromatin assembly (GO:0031497)3.37938965
75hyperosmotic salinity response (GO:0042538)3.37147133
76histone exchange (GO:0043486)3.35395248
77sperm-egg recognition (GO:0035036)3.35131306
78single fertilization (GO:0007338)3.33721009
79DNA replication-dependent nucleosome organization (GO:0034723)3.33489916
80DNA replication-dependent nucleosome assembly (GO:0006335)3.33489916
81regulation of cytokine production involved in inflammatory response (GO:1900015)3.25355536
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25001629
83citrulline biosynthetic process (GO:0019240)3.22521707
84regulation of reproductive process (GO:2000241)3.22147291
85N-terminal protein amino acid acetylation (GO:0006474)3.17795367
86chromatin assembly or disassembly (GO:0006333)3.13596806
87negative regulation of execution phase of apoptosis (GO:1900118)3.13330912
88DNA replication-independent nucleosome assembly (GO:0006336)3.12057109
89DNA replication-independent nucleosome organization (GO:0034724)3.12057109
90paraxial mesoderm development (GO:0048339)3.10975061
91regulation of female receptivity (GO:0045924)3.10781476
92DNA replication checkpoint (GO:0000076)3.08903267
93nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.08895619
94regulation of spindle checkpoint (GO:0090231)3.06955945
95stress granule assembly (GO:0034063)3.04467702
96regulation of chromatin silencing (GO:0031935)3.04202802
97regulation of calcium ion-dependent exocytosis (GO:0017158)3.02739185
98negative regulation of hormone biosynthetic process (GO:0032353)3.02221658
99piRNA metabolic process (GO:0034587)10.9207442
100regulation of DNA methylation (GO:0044030)10.3374794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.13107379
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.03619325
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.36809382
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.36809382
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.36809382
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.23623592
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.10732917
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.02074471
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.68259506
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42744763
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.35104693
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32683550
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24695798
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.24477295
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.12308753
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07653836
17EZH2_22144423_ChIP-Seq_EOC_Human15.4380646
18GATA1_26923725_Chip-Seq_HPCs_Mouse1.76917721
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76075209
20GBX2_23144817_ChIP-Seq_PC3_Human1.70508926
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66041970
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64855874
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.51152389
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46038285
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43432154
26AR_21909140_ChIP-Seq_LNCAP_Human1.37299599
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34820807
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.27527186
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22937688
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21491834
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18431177
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18021764
33CBP_20019798_ChIP-Seq_JUKART_Human1.17859180
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17859180
35TCF4_23295773_ChIP-Seq_U87_Human1.14954254
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12590306
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12319525
38CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11049595
39PRDM14_20953172_ChIP-Seq_ESCs_Human1.10427759
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08755212
41IRF1_19129219_ChIP-ChIP_H3396_Human1.08046548
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05241127
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05141972
44AR_25329375_ChIP-Seq_VCAP_Human1.03290395
45RUNX2_22187159_ChIP-Seq_PCA_Human1.01917738
46SMAD4_21741376_ChIP-Seq_EPCs_Human0.99503901
47LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98972927
48HTT_18923047_ChIP-ChIP_STHdh_Human0.97900857
49NANOG_20526341_ChIP-Seq_ESCs_Human0.96622552
50SALL1_21062744_ChIP-ChIP_HESCs_Human0.96522457
51FOXH1_21741376_ChIP-Seq_EPCs_Human0.95948671
52RNF2_27304074_Chip-Seq_NSC_Mouse0.95536760
53SMAD4_21799915_ChIP-Seq_A2780_Human0.95306649
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93376291
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93266371
56CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93120629
57FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90779144
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89691347
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89195822
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88934873
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88934873
62EZH2_27304074_Chip-Seq_ESCs_Mouse0.85906496
63GF1_26923725_Chip-Seq_HPCs_Mouse0.85484396
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84974451
65EWS_26573619_Chip-Seq_HEK293_Human0.84942284
66STAT3_23295773_ChIP-Seq_U87_Human0.84791249
67ZNF274_21170338_ChIP-Seq_K562_Hela0.83749920
68GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82243747
69CBP_21632823_ChIP-Seq_H3396_Human0.81813142
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80543424
71TAL1_26923725_Chip-Seq_HPCs_Mouse0.80214678
72SMAD_19615063_ChIP-ChIP_OVARY_Human0.80204179
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79489946
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79441069
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78163626
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76726552
77TP53_22573176_ChIP-Seq_HFKS_Human0.76630072
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75242926
79NR3C1_23031785_ChIP-Seq_PC12_Mouse0.72910495
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.72577084
81AHR_22903824_ChIP-Seq_MCF-7_Human0.72166811
82PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72069487
83RUNX1_26923725_Chip-Seq_HPCs_Mouse0.70884292
84CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.69850994
85KLF4_19829295_ChIP-Seq_ESCs_Human0.69525282
86SMRT_27268052_Chip-Seq_Bcells_Human0.68061185
87REST_21632747_ChIP-Seq_MESCs_Mouse0.68050820
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.67591311
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.66899866
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.66747170
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.66458706
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.65051691
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.64808867
94SOX2_21211035_ChIP-Seq_LN229_Gbm0.64342045
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.62830993
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.62806595
97P300_19829295_ChIP-Seq_ESCs_Human0.62365070
98BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.61324740
99BCAT_22108803_ChIP-Seq_LS180_Human0.61244524
100GATA3_26560356_Chip-Seq_TH1_Human0.61153622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.32197370
2MP0008877_abnormal_DNA_methylation5.27153939
3MP0006292_abnormal_olfactory_placode3.76828468
4MP0008789_abnormal_olfactory_epithelium3.45772283
5MP0005395_other_phenotype3.42763991
6MP0008057_abnormal_DNA_replication3.36514741
7MP0005499_abnormal_olfactory_system3.10197811
8MP0005394_taste/olfaction_phenotype3.10197811
9MP0005360_urolithiasis2.90007026
10MP0003890_abnormal_embryonic-extraembry2.83693394
11MP0002210_abnormal_sex_determination2.77785003
12MP0001929_abnormal_gametogenesis2.76783601
13MP0002139_abnormal_hepatobiliary_system2.75327472
14MP0010234_abnormal_vibrissa_follicle2.74573009
15MP0003693_abnormal_embryo_hatching2.72619201
16MP0003879_abnormal_hair_cell2.70026137
17MP0003699_abnormal_female_reproductive2.63121544
18MP0008058_abnormal_DNA_repair2.40562683
19MP0010030_abnormal_orbit_morphology2.22682567
20MP0000653_abnormal_sex_gland2.14798354
21MP0002138_abnormal_hepatobiliary_system2.10348783
22MP0003077_abnormal_cell_cycle2.06693031
23MP0003183_abnormal_peptide_metabolism2.02213883
24MP0010094_abnormal_chromosome_stability1.92182975
25MP0000566_synostosis1.90129964
26MP0002161_abnormal_fertility/fecundity1.83891738
27MP0001145_abnormal_male_reproductive1.81228581
28MP0002234_abnormal_pharynx_morphology1.80280820
29MP0003950_abnormal_plasma_membrane1.73962681
30MP0002160_abnormal_reproductive_system1.73839964
31MP0003111_abnormal_nucleus_morphology1.69787142
32MP0001119_abnormal_female_reproductive1.61400279
33MP0005410_abnormal_fertilization1.57618209
34MP0010368_abnormal_lymphatic_system1.54684126
35MP0003698_abnormal_male_reproductive1.54218259
36MP0010307_abnormal_tumor_latency1.50128419
37MP0009840_abnormal_foam_cell1.42534598
38MP0008932_abnormal_embryonic_tissue1.37947597
39MP0001730_embryonic_growth_arrest1.33043429
40MP0001986_abnormal_taste_sensitivity1.30208984
41MP0000631_abnormal_neuroendocrine_gland1.28589506
42MP0005389_reproductive_system_phenotype1.24541748
43MP0005646_abnormal_pituitary_gland1.23133299
44MP0004142_abnormal_muscle_tone1.20964448
45MP0000427_abnormal_hair_cycle1.19552132
46MP0003121_genomic_imprinting1.16975855
47MP0001293_anophthalmia1.13067011
48MP0000762_abnormal_tongue_morphology1.11295780
49MP0005647_abnormal_sex_gland1.09853043
50MP0010678_abnormal_skin_adnexa1.09281348
51MP0009379_abnormal_foot_pigmentation1.07977342
52MP0002233_abnormal_nose_morphology1.02843715
53MP0003252_abnormal_bile_duct1.02410350
54MP0005380_embryogenesis_phenotype0.99421316
55MP0001672_abnormal_embryogenesis/_devel0.99421316
56MP0003941_abnormal_skin_development0.99185925
57MP0000678_abnormal_parathyroid_gland0.94510094
58MP0003136_yellow_coat_color0.93206467
59MP0002272_abnormal_nervous_system0.92616076
60MP0006276_abnormal_autonomic_nervous0.88071493
61MP0002796_impaired_skin_barrier0.87232960
62MP0003119_abnormal_digestive_system0.86817272
63MP0000350_abnormal_cell_proliferation0.84452872
64MP0001984_abnormal_olfaction0.76821763
65MP0005085_abnormal_gallbladder_physiolo0.72509745
66MP0004957_abnormal_blastocyst_morpholog0.72380590
67MP0001664_abnormal_digestion0.71467622
68MP0005501_abnormal_skin_physiology0.68495657
69MP0002084_abnormal_developmental_patter0.66264433
70MP0000049_abnormal_middle_ear0.66051000
71MP0001502_abnormal_circadian_rhythm0.65499628
72MP0001963_abnormal_hearing_physiology0.63492292
73MP0001666_abnormal_nutrient_absorption0.62682562
74MP0001324_abnormal_eye_pigmentation0.61343097
75MP0005551_abnormal_eye_electrophysiolog0.59461302
76MP0005075_abnormal_melanosome_morpholog0.56005259
77MP0000015_abnormal_ear_pigmentation0.55145757
78MP0003868_abnormal_feces_composition0.54834202
79MP0002089_abnormal_postnatal_growth/wei0.54344130
80MP0008995_early_reproductive_senescence0.51189402
81MP0002085_abnormal_embryonic_tissue0.50153590
82MP0000383_abnormal_hair_follicle0.49519830
83MP0001697_abnormal_embryo_size0.48796479
84MP0002735_abnormal_chemical_nociception0.48608329
85MP0003935_abnormal_craniofacial_develop0.47582599
86MP0005076_abnormal_cell_differentiation0.46304974
87MP0005174_abnormal_tail_pigmentation0.44749898
88MP0004381_abnormal_hair_follicle0.43633200
89MP0002127_abnormal_cardiovascular_syste0.42937705
90MP0003984_embryonic_growth_retardation0.42804060
91MP0002095_abnormal_skin_pigmentation0.41372147
92MP0003936_abnormal_reproductive_system0.41238115
93MP0003959_abnormal_lean_body0.40461384
94MP0002734_abnormal_mechanical_nocicepti0.40228009
95MP0002088_abnormal_embryonic_growth/wei0.39947197
96MP0005503_abnormal_tendon_morphology0.38810556
97MP0002873_normal_phenotype0.38673552
98MP0001919_abnormal_reproductive_system0.38564076
99MP0002638_abnormal_pupillary_reflex0.38486417
100MP0002169_no_abnormal_phenotype0.38225844

Predicted human phenotypes

RankGene SetZ-score
1Osteomalacia (HP:0002749)5.69751597
2Male infertility (HP:0003251)5.47870048
3Lip pit (HP:0100267)4.99769519
4Supernumerary spleens (HP:0009799)4.89273908
5Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.81937578
6Azoospermia (HP:0000027)4.71629463
7Papillary thyroid carcinoma (HP:0002895)4.69585899
8Abnormality of abdominal situs (HP:0011620)4.55132923
9Abdominal situs inversus (HP:0003363)4.55132923
10Gonadotropin excess (HP:0000837)4.49281591
11Facial hemangioma (HP:0000329)4.47100744
12Hypophosphatemic rickets (HP:0004912)4.44743035
13Hypoplasia of the fovea (HP:0007750)4.36530824
14Aplasia/Hypoplasia of the fovea (HP:0008060)4.36530824
15Premature ovarian failure (HP:0008209)4.29255715
16Infertility (HP:0000789)4.23934184
17Anterior segment dysgenesis (HP:0007700)4.17279197
18Impulsivity (HP:0100710)4.10016648
19Oligodactyly (hands) (HP:0001180)3.94299410
20Cholecystitis (HP:0001082)3.89092987
21Abnormal gallbladder physiology (HP:0012438)3.89092987
22Abnormality of the fovea (HP:0000493)3.82603796
23Chromsome breakage (HP:0040012)3.69765584
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64404811
25Abnormal spermatogenesis (HP:0008669)3.55682824
26Malnutrition (HP:0004395)3.53307139
27Septo-optic dysplasia (HP:0100842)3.39009480
28Median cleft lip (HP:0000161)3.30238238
29Conjunctival telangiectasia (HP:0000524)3.17663201
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.16626128
31Loss of speech (HP:0002371)3.11943868
32Urethral obstruction (HP:0000796)2.99078977
33Absent septum pellucidum (HP:0001331)2.94716044
34Oligodactyly (HP:0012165)2.93296262
35Short tibia (HP:0005736)2.87902211
36Apathy (HP:0000741)2.83240140
37Diminished motivation (HP:0000745)2.82201746
38Capillary hemangiomas (HP:0005306)2.80073968
39Truncal obesity (HP:0001956)2.76668244
40Proximal tubulopathy (HP:0000114)2.75826981
41Hypokinesia (HP:0002375)2.74591192
42Aplasia/Hypoplasia of the macula (HP:0008059)2.72805650
43Muscle stiffness (HP:0003552)2.72204594
44Abnormality of the labia minora (HP:0012880)2.66677727
45Metaphyseal irregularity (HP:0003025)2.58666061
46Spinal cord compression (HP:0002176)2.54710089
47Skin pits (HP:0100276)2.54217637
48Aplasia of the musculature (HP:0100854)2.53873955
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.52619232
50Thyroid carcinoma (HP:0002890)2.52394512
51Aplasia/Hypoplasia affecting the retina (HP:0008061)2.48810421
52Generalized aminoaciduria (HP:0002909)2.47411116
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.46168968
54Abnormality of the septum pellucidum (HP:0007375)2.38745591
55Wrist flexion contracture (HP:0001239)2.37708290
56Enlarged penis (HP:0000040)2.34984915
57Abnormal lung lobation (HP:0002101)2.34840552
58Lower limb hyperreflexia (HP:0002395)2.33450798
59Myokymia (HP:0002411)2.27054729
60Bundle branch block (HP:0011710)2.20885484
61Fair hair (HP:0002286)2.19111362
62Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18307086
63Hydroureter (HP:0000072)2.10427123
64Dysdiadochokinesis (HP:0002075)2.08277507
65Abnormality of the phalanges of the hallux (HP:0010057)2.05912508
66Anhidrosis (HP:0000970)2.05524493
67Sensory axonal neuropathy (HP:0003390)2.02962637
68Nephroblastoma (Wilms tumor) (HP:0002667)2.01870054
69Rickets (HP:0002748)2.01287622
70Striae distensae (HP:0001065)2.01004793
71Increased circulating renin level (HP:0000848)1.99173959
72Heterotopia (HP:0002282)1.97931416
73Duodenal stenosis (HP:0100867)1.94126998
74Small intestinal stenosis (HP:0012848)1.94126998
75Abnormality of calcium-phosphate metabolism (HP:0100530)1.93137320
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.92745958
77Abnormality of chromosome segregation (HP:0002916)1.91690952
78Maternal diabetes (HP:0009800)1.91066112
79Stillbirth (HP:0003826)1.89837855
80Embryonal renal neoplasm (HP:0011794)1.89059987
81Posterior subcapsular cataract (HP:0007787)1.87517201
82Microglossia (HP:0000171)1.86959735
83Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83225089
84Abnormal ciliary motility (HP:0012262)1.82996176
85Abnormality of chromosome stability (HP:0003220)1.81053124
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.77545565
87Hypergonadotropic hypogonadism (HP:0000815)1.76871141
88Nausea (HP:0002018)1.75311478
89Abnormality of the salivary glands (HP:0010286)1.73643026
90Intrahepatic cholestasis (HP:0001406)1.73243716
91Abnormality of the anterior chamber (HP:0000593)1.72751273
92Cleft eyelid (HP:0000625)1.71761652
93Abnormal biliary tract physiology (HP:0012439)1.71630625
94Bile duct proliferation (HP:0001408)1.71630625
95Neurofibrillary tangles (HP:0002185)1.70577935
96Neoplasm of the oral cavity (HP:0100649)1.68611484
97Abnormality of the labia (HP:0000058)1.67072507
98Abnormal urine phosphate concentration (HP:0012599)1.66668658
99Non-midline cleft lip (HP:0100335)1.66261180
100Cranial hyperostosis (HP:0004437)1.65897485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.72127360
2MAP3K136.32166191
3ARAF6.16248008
4STK243.22367793
5BRAF3.08424543
6TTK2.82628846
7MOS2.73610505
8NEK62.73315643
9MET2.61358719
10TAOK32.51016896
11KSR22.43722749
12CDK122.21688135
13AURKA2.03471055
14CDK192.01329041
15RAF11.90983239
16CDC71.70579424
17KSR11.57161319
18EIF2AK31.46046281
19CDK91.45129436
20PRKCI1.38906992
21NTRK21.37087216
22BUB11.32845453
23PNCK1.31686644
24PLK11.29114285
25CDK71.26740263
26STK31.21916684
27TRIM281.20520613
28MELK1.20274927
29PTK21.18603007
30BRSK11.09142847
31TNIK1.08824784
32NTRK30.98861435
33CAMK1G0.95095467
34PIM10.93379911
35MAP3K80.91445601
36CHEK10.87676141
37NEK20.86801289
38WNK10.86250283
39BMPR1B0.81121019
40CAMK1D0.77595316
41ZAK0.74282338
42CDK80.67668966
43TNK20.66267345
44NEK90.65057986
45CDK20.64919847
46STK390.64235311
47ACVR1B0.60265982
48PLK30.57589761
49MARK30.57143744
50CSNK1G10.57110646
51ATM0.55693521
52MAPKAPK30.53298259
53AURKB0.52027852
54DMPK0.51552791
55CHEK20.51031640
56TYRO30.51007753
57NUAK10.50466196
58MAP3K40.50184246
59TIE10.49134533
60ATR0.48391925
61PAK10.47719978
62LRRK20.46617645
63TGFBR10.45003004
64OXSR10.43975002
65PRKG10.43772331
66CDK10.43352277
67BRSK20.41249204
68EEF2K0.40415703
69PDK10.39461436
70MTOR0.39169246
71PRKCZ0.36655114
72MAP3K50.35939804
73MAPK130.32543598
74MST40.32455063
75PKN10.32389267
76CSNK1D0.31666889
77TLK10.31360291
78CSNK1E0.29225481
79VRK10.28754328
80CDK50.27480431
81LATS10.27010626
82CSNK1G30.26461849
83PLK40.25837689
84AKT20.25128213
85PDPK10.24772714
86EGFR0.23121565
87GSK3B0.22242335
88PRKACB0.21896059
89CDK11A0.21824542
90BRD40.21810514
91MAP3K10.21161034
92SRPK10.20228210
93STK380.19524315
94CAMK2A0.19341774
95TRPM70.18502063
96MAPK100.18381806
97MAPK10.18258148
98PBK0.16730162
99CAMK10.16602857
100MAP2K10.15794901

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.44854715
2Cell cycle_Homo sapiens_hsa041104.60455269
3Mismatch repair_Homo sapiens_hsa034304.29311081
4Oocyte meiosis_Homo sapiens_hsa041143.55029309
5Base excision repair_Homo sapiens_hsa034103.39927501
6Dorso-ventral axis formation_Homo sapiens_hsa043203.03584859
7Ovarian steroidogenesis_Homo sapiens_hsa049133.01100879
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.91141923
9DNA replication_Homo sapiens_hsa030302.86545331
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.71953366
11Caffeine metabolism_Homo sapiens_hsa002322.66545909
12RNA degradation_Homo sapiens_hsa030182.59701449
13Nucleotide excision repair_Homo sapiens_hsa034202.51128673
14Fanconi anemia pathway_Homo sapiens_hsa034602.38717806
15Homologous recombination_Homo sapiens_hsa034402.23199030
16RNA transport_Homo sapiens_hsa030131.99042426
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91626955
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.83030868
19Olfactory transduction_Homo sapiens_hsa047401.80240062
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.79723070
21Circadian rhythm_Homo sapiens_hsa047101.70317330
22p53 signaling pathway_Homo sapiens_hsa041151.67816728
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48537992
24Thyroid cancer_Homo sapiens_hsa052161.45219767
25RNA polymerase_Homo sapiens_hsa030201.40125363
26mRNA surveillance pathway_Homo sapiens_hsa030151.36672951
27Folate biosynthesis_Homo sapiens_hsa007901.36189204
28Gap junction_Homo sapiens_hsa045401.30120336
29Fatty acid elongation_Homo sapiens_hsa000621.13296423
30ABC transporters_Homo sapiens_hsa020101.07788562
31Phototransduction_Homo sapiens_hsa047441.06574813
32Inositol phosphate metabolism_Homo sapiens_hsa005620.89008549
33SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88035204
34Nicotine addiction_Homo sapiens_hsa050330.87013250
35TGF-beta signaling pathway_Homo sapiens_hsa043500.82729349
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81531375
37mTOR signaling pathway_Homo sapiens_hsa041500.79732544
38Taste transduction_Homo sapiens_hsa047420.75387204
39Bile secretion_Homo sapiens_hsa049760.74023292
40Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68429023
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.65765906
42Regulation of autophagy_Homo sapiens_hsa041400.65484366
43Morphine addiction_Homo sapiens_hsa050320.65160612
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64170935
45Long-term depression_Homo sapiens_hsa047300.63016299
46Viral carcinogenesis_Homo sapiens_hsa052030.61059444
47FoxO signaling pathway_Homo sapiens_hsa040680.60741651
48GABAergic synapse_Homo sapiens_hsa047270.60042313
49Adherens junction_Homo sapiens_hsa045200.51284383
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50395611
51Small cell lung cancer_Homo sapiens_hsa052220.49283919
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47955079
53Serotonergic synapse_Homo sapiens_hsa047260.46709957
54Purine metabolism_Homo sapiens_hsa002300.46335096
55ErbB signaling pathway_Homo sapiens_hsa040120.45721129
56MicroRNAs in cancer_Homo sapiens_hsa052060.45625021
57Synaptic vesicle cycle_Homo sapiens_hsa047210.42988646
58Notch signaling pathway_Homo sapiens_hsa043300.40111547
59Herpes simplex infection_Homo sapiens_hsa051680.37741205
60HTLV-I infection_Homo sapiens_hsa051660.34931060
61Huntingtons disease_Homo sapiens_hsa050160.34108785
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32755376
63Propanoate metabolism_Homo sapiens_hsa006400.31743342
64Wnt signaling pathway_Homo sapiens_hsa043100.29356438
65Arginine biosynthesis_Homo sapiens_hsa002200.28694206
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26035089
67Non-homologous end-joining_Homo sapiens_hsa034500.25456584
68Ras signaling pathway_Homo sapiens_hsa040140.24753847
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23136170
70Pyrimidine metabolism_Homo sapiens_hsa002400.22892827
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22227637
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22167851
73Vitamin digestion and absorption_Homo sapiens_hsa049770.22047359
74Endometrial cancer_Homo sapiens_hsa052130.21295229
75Hippo signaling pathway_Homo sapiens_hsa043900.20920188
76Arginine and proline metabolism_Homo sapiens_hsa003300.19629921
77Oxytocin signaling pathway_Homo sapiens_hsa049210.19211840
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18076224
79Protein digestion and absorption_Homo sapiens_hsa049740.17132088
80Cholinergic synapse_Homo sapiens_hsa047250.15480266
81Prostate cancer_Homo sapiens_hsa052150.14548257
82Renal cell carcinoma_Homo sapiens_hsa052110.14472607
83Spliceosome_Homo sapiens_hsa030400.13057279
84Lysine degradation_Homo sapiens_hsa003100.12777212
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.12365968
86MAPK signaling pathway_Homo sapiens_hsa040100.11202819
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10498532
88Linoleic acid metabolism_Homo sapiens_hsa005910.10236602
89Non-small cell lung cancer_Homo sapiens_hsa052230.10156830
90Hepatitis B_Homo sapiens_hsa051610.09888512
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.09421231
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.09041411
93cAMP signaling pathway_Homo sapiens_hsa040240.08907498
94Long-term potentiation_Homo sapiens_hsa047200.08622349
95Prion diseases_Homo sapiens_hsa050200.08107054
96Glutamatergic synapse_Homo sapiens_hsa047240.07114090
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05395574
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04524242
99Pyruvate metabolism_Homo sapiens_hsa006200.04232463
100Calcium signaling pathway_Homo sapiens_hsa040200.04223448

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