CXORF38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.38031244
2negative regulation of cell killing (GO:0031342)5.09732264
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.09732264
4regulation of B cell receptor signaling pathway (GO:0050855)4.96197070
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88842998
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44364200
7antigen processing and presentation of endogenous antigen (GO:0019883)4.37647461
8neutrophil activation involved in immune response (GO:0002283)4.25217733
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19871144
10negative regulation of interleukin-12 production (GO:0032695)4.12845488
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.06123768
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.06123768
13modulation by symbiont of host immune response (GO:0052553)4.06123768
14positive regulation by symbiont of host defense response (GO:0052509)4.06123768
15modulation by symbiont of host defense response (GO:0052031)4.06123768
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.06123768
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05778509
18negative thymic T cell selection (GO:0045060)3.92520734
19regulation of gamma-delta T cell activation (GO:0046643)3.92197242
20cellular response to interleukin-15 (GO:0071350)3.91157562
21negative T cell selection (GO:0043383)3.90333888
22response to interleukin-15 (GO:0070672)3.90306026
23cellular extravasation (GO:0045123)3.81024082
24neutrophil mediated immunity (GO:0002446)3.73571663
25macrophage activation involved in immune response (GO:0002281)3.72616586
26negative regulation of T cell mediated immunity (GO:0002710)3.67942731
27neutrophil activation (GO:0042119)3.65254707
28immunoglobulin mediated immune response (GO:0016064)3.63248394
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.61819291
30response to peptidoglycan (GO:0032494)3.59896849
31microglial cell activation (GO:0001774)3.58324467
32detection of other organism (GO:0098543)3.56499990
33regulation of gamma-delta T cell differentiation (GO:0045586)3.44806465
34T cell migration (GO:0072678)3.44124742
35response to type I interferon (GO:0034340)3.43061141
36detection of bacterium (GO:0016045)3.42846405
37cellular response to type I interferon (GO:0071357)3.41268337
38type I interferon signaling pathway (GO:0060337)3.41268337
39regulation of T cell mediated cytotoxicity (GO:0001914)3.39204664
40positive regulation of T cell mediated cytotoxicity (GO:0001916)3.38892426
41B cell receptor signaling pathway (GO:0050853)3.37325998
42respiratory burst (GO:0045730)3.32545222
43activated T cell proliferation (GO:0050798)3.31057901
44regulation of interferon-beta biosynthetic process (GO:0045357)3.27415479
45interferon-gamma-mediated signaling pathway (GO:0060333)3.26987460
46myeloid cell activation involved in immune response (GO:0002275)3.26377546
47granulocyte activation (GO:0036230)3.25457760
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23371143
49positive regulation of antigen processing and presentation (GO:0002579)3.23049136
50positive regulation of mast cell activation (GO:0033005)3.23034507
51regulation of antigen processing and presentation (GO:0002577)3.22999419
52tolerance induction (GO:0002507)3.21845859
53interferon-gamma production (GO:0032609)3.20344557
54leukocyte aggregation (GO:0070486)3.20239376
55regulation of alpha-beta T cell proliferation (GO:0046640)3.18693680
56regulation of B cell differentiation (GO:0045577)3.17239045
57response to host immune response (GO:0052572)3.17214165
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17214165
59defense response to protozoan (GO:0042832)3.16301300
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12294733
61myeloid leukocyte mediated immunity (GO:0002444)3.11633924
62regulation of mast cell activation (GO:0033003)3.09020180
63leukocyte degranulation (GO:0043299)3.08570855
64regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07712524
65negative regulation of leukocyte mediated immunity (GO:0002704)3.06946662
66T cell selection (GO:0045058)3.04949060
67response to protozoan (GO:0001562)3.04827295
68positive regulation of defense response to virus by host (GO:0002230)3.00561091
69detection of external biotic stimulus (GO:0098581)2.96956796
70mast cell activation (GO:0045576)2.96140679
71positive thymic T cell selection (GO:0045059)2.95647673
72positive regulation of granulocyte differentiation (GO:0030854)2.94624756
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94072562
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92033790
75DNA deamination (GO:0045006)2.91273018
76B cell mediated immunity (GO:0019724)2.90593423
77positive T cell selection (GO:0043368)2.88896372
78positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87861429
79regulation of T cell tolerance induction (GO:0002664)2.87430747
80dendritic cell migration (GO:0036336)2.85258761
81positive regulation of alpha-beta T cell proliferation (GO:0046641)2.83591228
82negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.83481632
83macrophage activation (GO:0042116)2.82498186
84regulation of tolerance induction (GO:0002643)2.82431708
85regulation of interferon-alpha production (GO:0032647)2.82258056
86positive regulation of interferon-alpha production (GO:0032727)2.80256211
87detection of molecule of bacterial origin (GO:0032490)2.79881525
88response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.78168901
89response to host (GO:0075136)2.78168901
90response to host defenses (GO:0052200)2.78168901
91regulation of interleukin-12 production (GO:0032655)2.76178316
92regulation of leukocyte mediated cytotoxicity (GO:0001910)2.75863561
93cytidine metabolic process (GO:0046087)2.74839673
94cytidine catabolic process (GO:0006216)2.74839673
95cytidine deamination (GO:0009972)2.74839673
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.73764921
97regulation of natural killer cell mediated immunity (GO:0002715)2.73764921
98negative regulation of interleukin-6 production (GO:0032715)2.73465933
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.72987747
100positive regulation of B cell differentiation (GO:0045579)2.72695931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.80728411
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.25956978
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.19492691
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88018854
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.56259319
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.37061656
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06024933
8RUNX_20019798_ChIP-Seq_JUKART_Human2.95116277
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.92328332
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.81480408
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54286850
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52876887
13MYB_26560356_Chip-Seq_TH2_Human2.49540436
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42014901
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.32433454
16SPI1_23547873_ChIP-Seq_NB4_Human2.27532940
17GATA3_26560356_Chip-Seq_TH2_Human2.15647417
18ZNF274_21170338_ChIP-Seq_K562_Hela2.09500936
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00657423
20MYB_26560356_Chip-Seq_TH1_Human1.96310372
21GATA3_27048872_Chip-Seq_THYMUS_Human1.94736111
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93830029
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91961088
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91371739
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90912933
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86366030
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83799940
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79414934
29MAF_26560356_Chip-Seq_TH1_Human1.75966907
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74283954
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.67955646
32VDR_24787735_ChIP-Seq_THP-1_Human1.64353682
33SCL_19346495_ChIP-Seq_HPC-7_Human1.63514181
34SPI1_23127762_ChIP-Seq_K562_Human1.60136067
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55392935
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53995753
37VDR_24763502_ChIP-Seq_THP-1_Human1.53670168
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50728351
39UTX_26944678_Chip-Seq_JUKART_Human1.49499838
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46314238
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40812180
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.38241903
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32230279
44IRF1_19129219_ChIP-ChIP_H3396_Human1.32098035
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29588414
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28288030
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27125234
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.25910772
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23200840
50MAF_26560356_Chip-Seq_TH2_Human1.18071347
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16932771
52VDR_21846776_ChIP-Seq_THP-1_Human1.16876902
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16358670
54VDR_23849224_ChIP-Seq_CD4+_Human1.11636722
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11629422
56SMRT_27268052_Chip-Seq_Bcells_Human1.10148972
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07825174
58GATA3_26560356_Chip-Seq_TH1_Human1.07265807
59CIITA_25753668_ChIP-Seq_RAJI_Human1.07037109
60PU_27001747_Chip-Seq_BMDM_Mouse1.06733253
61VDR_22108803_ChIP-Seq_LS180_Human1.05953209
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05837897
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02728255
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02104308
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02095820
66RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00839136
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98260973
68* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98043572
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97829412
70GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96029180
71GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95709305
72EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95033153
73ER_23166858_ChIP-Seq_MCF-7_Human0.93496843
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92939210
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92930430
76TP53_22573176_ChIP-Seq_HFKS_Human0.91455687
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90915304
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90681376
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89949256
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88827821
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87675291
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87514893
83PRDM14_20953172_ChIP-Seq_ESCs_Human0.85747632
84MYC_22102868_ChIP-Seq_BL_Human0.85706801
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85347007
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84692752
87STAT1_20625510_ChIP-Seq_HELA_Human0.84298839
88IGF1R_20145208_ChIP-Seq_DFB_Human0.84202760
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83642540
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82320692
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81766746
92BCL6_27268052_Chip-Seq_Bcells_Human0.81656775
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81263756
94AR_20517297_ChIP-Seq_VCAP_Human0.80691821
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80405721
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.80405721
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78455920
98* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77964251
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77896066
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.77664503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.38327879
2MP0001835_abnormal_antigen_presentation3.85116115
3MP0005671_abnormal_response_to3.71957964
4MP0003436_decreased_susceptibility_to3.15090269
5MP0001800_abnormal_humoral_immune3.12609460
6MP0000685_abnormal_immune_system3.02176740
7MP0005387_immune_system_phenotype2.98229206
8MP0001790_abnormal_immune_system2.98229206
9MP0005000_abnormal_immune_tolerance2.90328275
10MP0009785_altered_susceptibility_to2.85062927
11MP0006082_CNS_inflammation2.78229740
12MP0002723_abnormal_immune_serum2.69995379
13MP0002419_abnormal_innate_immunity2.66292950
14MP0002452_abnormal_antigen_presenting2.63180537
15MP0003303_peritoneal_inflammation2.62687702
16MP0005025_abnormal_response_to2.62509373
17MP0002148_abnormal_hypersensitivity_rea2.61325766
18MP0002420_abnormal_adaptive_immunity2.51118804
19MP0001819_abnormal_immune_cell2.48721748
20MP0003763_abnormal_thymus_physiology2.28632051
21MP0002138_abnormal_hepatobiliary_system1.93494751
22MP0000716_abnormal_immune_system1.91264796
23MP0002405_respiratory_system_inflammati1.88115510
24MP0005310_abnormal_salivary_gland1.86384830
25MP0001845_abnormal_inflammatory_respons1.84914179
26MP0002398_abnormal_bone_marrow1.79509038
27MP0010155_abnormal_intestine_physiology1.77600069
28MP0002277_abnormal_respiratory_mucosa1.75508692
29MP0003300_gastrointestinal_ulcer1.75148325
30MP0000569_abnormal_digit_pigmentation1.71583445
31MP0009764_decreased_sensitivity_to1.71382695
32MP0001873_stomach_inflammation1.69438156
33MP0000689_abnormal_spleen_morphology1.66435751
34MP0009333_abnormal_splenocyte_physiolog1.65907556
35MP0001533_abnormal_skeleton_physiology1.60877318
36MP0001986_abnormal_taste_sensitivity1.54390464
37MP0002163_abnormal_gland_morphology1.49867846
38MP0002166_altered_tumor_susceptibility1.48778646
39MP0005464_abnormal_platelet_physiology1.48548739
40MP0002722_abnormal_immune_system1.46440750
41MP0002429_abnormal_blood_cell1.45297728
42MP0008469_abnormal_protein_level1.42860958
43MP0003866_abnormal_defecation1.42226814
44MP0003787_abnormal_imprinting1.40286705
45MP0003172_abnormal_lysosome_physiology1.32077510
46MP0000703_abnormal_thymus_morphology1.27089433
47MP0003183_abnormal_peptide_metabolism1.22433607
48MP0005075_abnormal_melanosome_morpholog1.19843623
49MP0003195_calcinosis1.10984099
50MP0002006_tumorigenesis1.10438804
51MP0002009_preneoplasia1.09753048
52MP0004947_skin_inflammation1.09418598
53MP0001663_abnormal_digestive_system1.06100326
54MP0004381_abnormal_hair_follicle1.02123775
55MP0000465_gastrointestinal_hemorrhage1.01847707
56MP0002693_abnormal_pancreas_physiology1.00216717
57MP0008877_abnormal_DNA_methylation1.00173909
58MP0002928_abnormal_bile_duct0.99880764
59MP0003252_abnormal_bile_duct0.99287721
60MP0003045_fibrosis0.98884278
61MP0002396_abnormal_hematopoietic_system0.97632329
62MP0004883_abnormal_blood_vessel0.94174869
63MP0008875_abnormal_xenobiotic_pharmacok0.92473485
64MP0005379_endocrine/exocrine_gland_phen0.90713005
65MP0005084_abnormal_gallbladder_morpholo0.89404103
66MP0002933_joint_inflammation0.85531321
67MP0009763_increased_sensitivity_to0.84930927
68MP0000015_abnormal_ear_pigmentation0.84516766
69MP0005174_abnormal_tail_pigmentation0.82978655
70MP0009278_abnormal_bone_marrow0.77502078
71MP0003828_pulmonary_edema0.74347334
72MP0002998_abnormal_bone_remodeling0.73910491
73MP0001545_abnormal_hematopoietic_system0.73905939
74MP0005397_hematopoietic_system_phenotyp0.73905939
75MP0003646_muscle_fatigue0.73666025
76MP0002132_abnormal_respiratory_system0.73002623
77MP0008872_abnormal_physiological_respon0.72910711
78MP0005164_abnormal_response_to0.72221099
79MP0000427_abnormal_hair_cycle0.71706669
80MP0003806_abnormal_nucleotide_metabolis0.70180017
81MP0004043_abnormal_pH_regulation0.69674195
82MP0001853_heart_inflammation0.67271529
83MP0004142_abnormal_muscle_tone0.67151052
84MP0004130_abnormal_muscle_cell0.66705407
85MP0002136_abnormal_kidney_physiology0.66063432
86MP0001919_abnormal_reproductive_system0.65475084
87MP0002876_abnormal_thyroid_physiology0.62773524
88MP0005166_decreased_susceptibility_to0.62341566
89MP0000858_altered_metastatic_potential0.62097964
90MP0009765_abnormal_xenobiotic_induced0.61422432
91MP0005167_abnormal_blood-brain_barrier0.60704156
92MP0008961_abnormal_basal_metabolism0.60287798
93MP0002837_dystrophic_cardiac_calcinosis0.58802530
94MP0000371_diluted_coat_color0.56704554
95MP0001765_abnormal_ion_homeostasis0.56110846
96MP0005381_digestive/alimentary_phenotyp0.54643564
97MP0000343_altered_response_to0.54154588
98MP0002653_abnormal_ependyma_morphology0.53996496
99MP0008873_increased_physiological_sensi0.53746460
100MP0002095_abnormal_skin_pigmentation0.53711604

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.87202357
2Retrobulbar optic neuritis (HP:0100654)4.83803263
3Optic neuritis (HP:0100653)4.83803263
4Stomatitis (HP:0010280)4.81584224
5Recurrent bacterial skin infections (HP:0005406)4.68191346
6Orchitis (HP:0100796)4.59945556
7Recurrent abscess formation (HP:0002722)4.56388812
8Eczematoid dermatitis (HP:0000976)4.48715160
9Elevated erythrocyte sedimentation rate (HP:0003565)4.32919914
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.19528145
11Recurrent fungal infections (HP:0002841)3.90127438
12Mediastinal lymphadenopathy (HP:0100721)3.78350224
13Abnormality of macrophages (HP:0004311)3.72221757
14Recurrent cutaneous fungal infections (HP:0011370)3.63964308
15Chronic mucocutaneous candidiasis (HP:0002728)3.63964308
16Encephalitis (HP:0002383)3.48430992
17Abnormality of T cell number (HP:0011839)3.43824943
18T lymphocytopenia (HP:0005403)3.38400149
19Meningitis (HP:0001287)3.36664316
20Gastrointestinal infarctions (HP:0005244)3.33796945
21Recurrent skin infections (HP:0001581)3.32191140
22Vasculitis (HP:0002633)3.31406478
23Keratoconjunctivitis (HP:0001096)3.29564162
24Keratoconjunctivitis sicca (HP:0001097)3.26782896
25Panhypogammaglobulinemia (HP:0003139)3.22256727
26Abnormality of T cells (HP:0002843)3.13283186
27Congenital stationary night blindness (HP:0007642)3.09398190
28Pustule (HP:0200039)3.05143838
29Pulmonary infiltrates (HP:0002113)3.02924975
30Hemoptysis (HP:0002105)3.01493869
31Recurrent gram-negative bacterial infections (HP:0005420)3.01123470
32Abnormality of T cell physiology (HP:0011840)2.89043693
33Obstructive lung disease (HP:0006536)2.87729354
34Chronic obstructive pulmonary disease (HP:0006510)2.87729354
35Stomach cancer (HP:0012126)2.72890385
36Recurrent viral infections (HP:0004429)2.65418023
37IgG deficiency (HP:0004315)2.60842468
38Abnormal rod and cone electroretinograms (HP:0008323)2.55386392
39Leukocytosis (HP:0001974)2.49991658
40Pancreatic cysts (HP:0001737)2.48443151
41Anorexia (HP:0002039)2.46249099
42Autoimmune thrombocytopenia (HP:0001973)2.44862335
43Lymphopenia (HP:0001888)2.40678203
44Urticaria (HP:0001025)2.40285144
45Alveolar cell carcinoma (HP:0006519)2.38525984
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37263826
47Chest pain (HP:0100749)2.35592996
48Hypochromic anemia (HP:0001931)2.34092980
49Episodic fever (HP:0001954)2.34048394
50Neoplasm of the tracheobronchial system (HP:0100552)2.33999316
51Hematochezia (HP:0002573)2.30915631
52Recurrent sinusitis (HP:0011108)2.26498342
53Recurrent bronchitis (HP:0002837)2.24316338
54Gangrene (HP:0100758)2.23832747
55Abnormality of the pleura (HP:0002103)2.23212669
56Hypochromic microcytic anemia (HP:0004840)2.22807503
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.22711082
58Chronic otitis media (HP:0000389)2.15906058
59Arterial thrombosis (HP:0004420)2.15004913
60Attenuation of retinal blood vessels (HP:0007843)2.14954901
61Eosinophilia (HP:0001880)2.14444697
62Inflammation of the large intestine (HP:0002037)2.14302797
63Autoimmune hemolytic anemia (HP:0001890)2.14280118
64Increased IgM level (HP:0003496)2.13638778
65Chronic diarrhea (HP:0002028)2.13027229
66Abnormality of eosinophils (HP:0001879)2.11495985
67Abnormality of the prostate (HP:0008775)2.10905110
68Increased cerebral lipofuscin (HP:0011813)2.10189793
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.08499652
70Spontaneous hematomas (HP:0007420)2.07122457
71Pulmonary embolism (HP:0002204)2.06950587
72Agammaglobulinemia (HP:0004432)2.06792888
73IgM deficiency (HP:0002850)2.05988267
74Keratitis (HP:0000491)2.05535676
75Granulocytopenia (HP:0001913)2.04305580
76Pancreatic fibrosis (HP:0100732)2.02258156
77Polyneuropathy (HP:0001271)1.98987960
78Abnormality of B cell number (HP:0010975)1.98170553
79Prolonged bleeding time (HP:0003010)1.95195330
80Abnormal drinking behavior (HP:0030082)1.94193338
81Polydipsia (HP:0001959)1.94193338
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92590808
83Parakeratosis (HP:0001036)1.92297060
84Abnormality of transition element cation homeostasis (HP:0011030)1.90916114
85Gastrointestinal inflammation (HP:0004386)1.90428670
86Severe combined immunodeficiency (HP:0004430)1.89661443
87Gingivitis (HP:0000230)1.89478900
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86965331
89Abnormality of liposaccharide metabolism (HP:0010968)1.86728136
90Abnormality of glycosphingolipid metabolism (HP:0004343)1.86728136
91Abnormality of glycolipid metabolism (HP:0010969)1.86728136
92Cheilitis (HP:0100825)1.84126737
93Vacuolated lymphocytes (HP:0001922)1.83086700
94Hyperventilation (HP:0002883)1.82846125
95Gastrointestinal stroma tumor (HP:0100723)1.81606600
96Abnormality of iron homeostasis (HP:0011031)1.80937182
97Joint swelling (HP:0001386)1.79825867
98Abnormality of the endocardium (HP:0004306)1.79541063
99Abolished electroretinogram (ERG) (HP:0000550)1.78999915
100Abnormality of midbrain morphology (HP:0002418)1.74734060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.06436017
2IRAK43.49197845
3FRK3.39026404
4RIPK43.38421818
5TAOK33.29086981
6TXK3.18664106
7BLK2.58546916
8MAP3K142.23440103
9IKBKE2.15055741
10SYK2.13191348
11CSK2.10710420
12TYK22.05689740
13ADRBK21.92447244
14ACVR1B1.91268988
15BTK1.90888734
16FES1.90787422
17JAK31.87080560
18GRK61.81198894
19IKBKB1.77049017
20TLK11.68362245
21KIT1.67818656
22TEC1.66377649
23TNK21.66368290
24CSF1R1.64487726
25LYN1.62749836
26ITK1.58172538
27ZAP701.55926387
28IRAK11.50531640
29LCK1.43519289
30HCK1.41797153
31BMPR21.39347660
32JAK11.38897082
33TBK11.37280553
34FGR1.34070233
35MAP2K31.27570762
36CAMKK21.23680797
37PRKCQ1.19987616
38MARK31.14340773
39MAP4K21.14127362
40NLK1.11647955
41BMPR1B1.08343369
42PIK3CG1.08081583
43MATK1.00603394
44JAK20.98622208
45NUAK10.94845418
46GRK10.94569623
47SIK30.93985488
48MAP3K130.90632444
49OXSR10.87250858
50ERN10.83823396
51SIK20.83514754
52MAP3K110.81149388
53PTK2B0.80306095
54CHUK0.78165731
55WNK30.77644215
56MAP2K60.77180676
57PDK10.75444968
58ZAK0.74128168
59ADRBK10.72235630
60GRK70.72067873
61YES10.71626321
62WNK40.70982244
63STK100.65664341
64DAPK20.65256300
65PIM10.64738924
66EPHB10.63166983
67SGK20.60019938
68EPHA30.57309940
69HIPK20.54765067
70MAP3K70.54673217
71IRAK20.53411907
72ABL10.50058323
73TAOK10.48283012
74RPS6KA50.45536887
75TGFBR10.41957091
76TRPM70.41007884
77STK110.40210646
78FGFR30.40020330
79MAP3K30.39532656
80PRKD20.38102598
81RPS6KA60.37948087
82FYN0.37614460
83MAPKAPK20.35069358
84PAK30.33953338
85INSRR0.33500845
86PDPK10.32735576
87MAPK70.31876678
88IGF1R0.29909183
89MAP2K20.29584610
90PRKCZ0.29307578
91LRRK20.29130309
92EGFR0.29081900
93MAPK130.28514925
94CDC42BPA0.28315584
95MAPK110.27682724
96PRKCD0.27671226
97ERBB30.26664804
98CAMKK10.25906709
99MAPK120.25756241
100SGK30.24966978

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.52098495
2Graft-versus-host disease_Homo sapiens_hsa053323.39075157
3Autoimmune thyroid disease_Homo sapiens_hsa053203.25937535
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.21114521
5Asthma_Homo sapiens_hsa053102.97434526
6Primary immunodeficiency_Homo sapiens_hsa053402.95616231
7Type I diabetes mellitus_Homo sapiens_hsa049402.83217155
8Leishmaniasis_Homo sapiens_hsa051402.75818823
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.68311185
10Staphylococcus aureus infection_Homo sapiens_hsa051502.53293979
11Osteoclast differentiation_Homo sapiens_hsa043802.15970865
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15008163
13Antigen processing and presentation_Homo sapiens_hsa046122.05424722
14Hematopoietic cell lineage_Homo sapiens_hsa046402.05352579
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.98155747
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.90995916
17Measles_Homo sapiens_hsa051621.86157045
18B cell receptor signaling pathway_Homo sapiens_hsa046621.85703662
19Tuberculosis_Homo sapiens_hsa051521.77046576
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75795417
21T cell receptor signaling pathway_Homo sapiens_hsa046601.71518556
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60300227
23Rheumatoid arthritis_Homo sapiens_hsa053231.55584105
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.55020113
25Influenza A_Homo sapiens_hsa051641.46440531
26Viral myocarditis_Homo sapiens_hsa054161.45658306
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41630038
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39411353
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33792410
30Herpes simplex infection_Homo sapiens_hsa051681.32632733
31Toxoplasmosis_Homo sapiens_hsa051451.31472876
32Legionellosis_Homo sapiens_hsa051341.30808462
33Chemokine signaling pathway_Homo sapiens_hsa040621.29683570
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26065225
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21188532
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20319216
37Malaria_Homo sapiens_hsa051441.19765880
38TNF signaling pathway_Homo sapiens_hsa046681.18756706
39African trypanosomiasis_Homo sapiens_hsa051431.04920891
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04631819
41Linoleic acid metabolism_Homo sapiens_hsa005911.02358295
42Phagosome_Homo sapiens_hsa041451.01582322
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94769581
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91856307
45Phototransduction_Homo sapiens_hsa047440.83932987
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83412801
47Caffeine metabolism_Homo sapiens_hsa002320.81269247
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81119642
49Hepatitis C_Homo sapiens_hsa051600.81025984
50Apoptosis_Homo sapiens_hsa042100.78340813
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78181157
52Pertussis_Homo sapiens_hsa051330.77391007
53Regulation of autophagy_Homo sapiens_hsa041400.77014734
54Lysosome_Homo sapiens_hsa041420.72934058
55Ether lipid metabolism_Homo sapiens_hsa005650.72869998
56Sulfur relay system_Homo sapiens_hsa041220.70640726
57Hepatitis B_Homo sapiens_hsa051610.68535100
58Platelet activation_Homo sapiens_hsa046110.67625428
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67205851
60Acute myeloid leukemia_Homo sapiens_hsa052210.65464722
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61546295
62Epstein-Barr virus infection_Homo sapiens_hsa051690.59373583
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58771679
64Arachidonic acid metabolism_Homo sapiens_hsa005900.57321467
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54510684
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52840853
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50447896
68Dorso-ventral axis formation_Homo sapiens_hsa043200.49581124
69Prolactin signaling pathway_Homo sapiens_hsa049170.49010558
70Tryptophan metabolism_Homo sapiens_hsa003800.45805905
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.45526877
72Nitrogen metabolism_Homo sapiens_hsa009100.45360122
73Glycerolipid metabolism_Homo sapiens_hsa005610.43859162
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38975089
75Systemic lupus erythematosus_Homo sapiens_hsa053220.38836307
76FoxO signaling pathway_Homo sapiens_hsa040680.37356201
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37356050
78Shigellosis_Homo sapiens_hsa051310.35260255
79Salmonella infection_Homo sapiens_hsa051320.34722153
80Collecting duct acid secretion_Homo sapiens_hsa049660.34011669
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.31191808
82Type II diabetes mellitus_Homo sapiens_hsa049300.31164005
83Viral carcinogenesis_Homo sapiens_hsa052030.30493374
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.29882420
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28221780
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.27613312
87Other glycan degradation_Homo sapiens_hsa005110.26506024
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.24760807
89ABC transporters_Homo sapiens_hsa020100.23749208
90Butanoate metabolism_Homo sapiens_hsa006500.23287317
91MAPK signaling pathway_Homo sapiens_hsa040100.22900223
92VEGF signaling pathway_Homo sapiens_hsa043700.22375002
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.21944163
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21666398
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.21496405
96Non-small cell lung cancer_Homo sapiens_hsa052230.21307438
97Insulin resistance_Homo sapiens_hsa049310.20352052
98HTLV-I infection_Homo sapiens_hsa051660.19802053
99Olfactory transduction_Homo sapiens_hsa047400.19768114
100Serotonergic synapse_Homo sapiens_hsa047260.19448606

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