CXORF21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)5.50632424
2positive regulation of gamma-delta T cell activation (GO:0046645)5.30794149
3response to peptidoglycan (GO:0032494)4.89452057
4positive regulation by symbiont of host defense response (GO:0052509)4.86375988
5modulation by symbiont of host defense response (GO:0052031)4.86375988
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.86375988
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.86375988
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.86375988
9modulation by symbiont of host immune response (GO:0052553)4.86375988
10regulation of B cell receptor signaling pathway (GO:0050855)4.72606899
11neutrophil activation involved in immune response (GO:0002283)4.68216161
12microglial cell activation (GO:0001774)4.39755999
13B cell mediated immunity (GO:0019724)4.36947270
14macrophage activation involved in immune response (GO:0002281)4.33840477
15negative regulation of interleukin-12 production (GO:0032695)4.27060531
16positive regulation of mast cell activation (GO:0033005)4.23942074
17cellular extravasation (GO:0045123)4.19178201
18antigen processing and presentation of endogenous antigen (GO:0019883)4.19144134
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.17796451
20detection of other organism (GO:0098543)4.12119522
21regulation of mast cell activation (GO:0033003)4.09752505
22positive regulation of mast cell degranulation (GO:0043306)4.05642018
23positive regulation of mast cell activation involved in immune response (GO:0033008)4.05642018
24interferon-gamma-mediated signaling pathway (GO:0060333)4.04020653
25detection of bacterium (GO:0016045)3.91076903
26regulation of mast cell degranulation (GO:0043304)3.89928010
27positive thymic T cell selection (GO:0045059)3.89262401
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83947622
29negative regulation of cell killing (GO:0031342)3.83947622
30regulation of hypersensitivity (GO:0002883)3.83302566
31myeloid cell activation involved in immune response (GO:0002275)3.81515887
32positive regulation of B cell differentiation (GO:0045579)3.81029693
33positive regulation of antigen processing and presentation (GO:0002579)3.78817697
34defense response to protozoan (GO:0042832)3.78706640
35B cell receptor signaling pathway (GO:0050853)3.75895678
36detection of molecule of bacterial origin (GO:0032490)3.74033098
37regulation of interferon-beta biosynthetic process (GO:0045357)3.68032765
38regulation of gamma-delta T cell activation (GO:0046643)3.66874170
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.66506479
40response to host immune response (GO:0052572)3.66506479
41regulation of mast cell activation involved in immune response (GO:0033006)3.64676354
42detection of external biotic stimulus (GO:0098581)3.63003323
43regulation of antigen processing and presentation (GO:0002577)3.62415585
44positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.58601536
45regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.57674006
46positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.56257880
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55192058
48macrophage activation (GO:0042116)3.54517307
49positive regulation of interferon-alpha production (GO:0032727)3.53467569
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.53261661
51T cell migration (GO:0072678)3.52696764
52regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.49498287
53response to protozoan (GO:0001562)3.49333704
54regulation of interferon-alpha production (GO:0032647)3.49077934
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45117301
56cellular response to type I interferon (GO:0071357)3.44759840
57type I interferon signaling pathway (GO:0060337)3.44759840
58response to type I interferon (GO:0034340)3.43104330
59regulation of B cell differentiation (GO:0045577)3.42631584
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41884838
61mast cell activation (GO:0045576)3.41239261
62detection of biotic stimulus (GO:0009595)3.40189874
63regulation of myeloid leukocyte mediated immunity (GO:0002886)3.38182930
64negative thymic T cell selection (GO:0045060)3.36456131
65neutrophil activation (GO:0042119)3.35910594
66T-helper 1 type immune response (GO:0042088)3.35632605
67positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.33750751
68positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.31051317
69regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.30406871
70neutrophil mediated immunity (GO:0002446)3.29637263
71respiratory burst (GO:0045730)3.28924180
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23187399
73response to muramyl dipeptide (GO:0032495)3.22665393
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.21813902
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.20635774
76response to host (GO:0075136)3.20635774
77response to host defenses (GO:0052200)3.20635774
78negative T cell selection (GO:0043383)3.17859120
79regulation of alpha-beta T cell proliferation (GO:0046640)3.15761425
80cellular response to interferon-gamma (GO:0071346)3.12696672
81regulation of growth of symbiont in host (GO:0044126)3.11035749
82negative regulation of growth of symbiont in host (GO:0044130)3.11035749
83negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.11035749
84modulation of growth of symbiont involved in interaction with host (GO:0044144)3.11035749
85regulation of leukocyte degranulation (GO:0043300)3.10277207
86positive T cell selection (GO:0043368)3.08769657
87granulocyte activation (GO:0036230)3.06252602
88leukocyte degranulation (GO:0043299)3.05937119
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04687017
90positive regulation of alpha-beta T cell proliferation (GO:0046641)3.04017738
91regulation of gamma-delta T cell differentiation (GO:0045586)3.02122586
92negative regulation of T cell mediated immunity (GO:0002710)3.00112591
93regulation of germinal center formation (GO:0002634)2.99682615
94regulation of B cell apoptotic process (GO:0002902)2.96944247
95positive regulation of B cell mediated immunity (GO:0002714)2.96019330
96positive regulation of immunoglobulin mediated immune response (GO:0002891)2.96019330
97positive regulation of type 2 immune response (GO:0002830)2.94848930
98positive regulation of interferon-beta production (GO:0032728)2.93058284
99regulation of interleukin-8 biosynthetic process (GO:0045414)2.92353227
100mast cell activation involved in immune response (GO:0002279)2.91019996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.49487664
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.92557085
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.83622393
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.85716535
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.69158806
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.66752743
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49613451
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.44100755
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.41786646
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07325194
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.97477834
12SPI1_23547873_ChIP-Seq_NB4_Human2.91180831
13SCL_19346495_ChIP-Seq_HPC-7_Human2.85159983
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66561710
15MYB_26560356_Chip-Seq_TH2_Human2.57758247
16GATA1_22025678_ChIP-Seq_K562_Human2.57217422
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52959905
18* VDR_24763502_ChIP-Seq_THP-1_Human2.52578240
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46130933
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40336645
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.30693738
22RUNX_20019798_ChIP-Seq_JUKART_Human2.28135484
23* VDR_21846776_ChIP-Seq_THP-1_Human2.27385367
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.23729861
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20977903
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18075798
27VDR_24787735_ChIP-Seq_THP-1_Human2.09511387
28MYB_26560356_Chip-Seq_TH1_Human2.06104379
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.04801300
30SPI1_23127762_ChIP-Seq_K562_Human2.01626300
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94357458
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93584330
33GATA3_26560356_Chip-Seq_TH2_Human1.91439924
34MAF_26560356_Chip-Seq_TH1_Human1.85924582
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85281437
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78478457
37GATA3_27048872_Chip-Seq_THYMUS_Human1.77891078
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77606206
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74732332
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.71787637
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71198020
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64707077
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63062523
44MYC_22102868_ChIP-Seq_BL_Human1.61032601
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58758336
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58220707
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57538527
48UTX_26944678_Chip-Seq_JUKART_Human1.54289820
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.51936917
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41484967
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27908340
52CIITA_25753668_ChIP-Seq_RAJI_Human1.26132804
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24947458
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23984208
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22842873
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22485483
57MAF_26560356_Chip-Seq_TH2_Human1.22232713
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.19383071
59PU_27001747_Chip-Seq_BMDM_Mouse1.19077712
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18825594
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15178525
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14576338
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13612303
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09420135
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09040346
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09015128
67VDR_23849224_ChIP-Seq_CD4+_Human1.07549030
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.07357316
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02998974
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00762327
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99512014
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98617876
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97108233
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96615908
75STAT1_20625510_ChIP-Seq_HELA_Human0.96420904
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96346283
77* SMRT_27268052_Chip-Seq_Bcells_Human0.96072325
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95525921
79SMAD_19615063_ChIP-ChIP_OVARY_Human0.94113396
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93251055
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92195572
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92195544
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89946141
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88337136
85BCL6_27268052_Chip-Seq_Bcells_Human0.88018803
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87649811
87FOXP3_21729870_ChIP-Seq_TREG_Human0.85717539
88P300_27268052_Chip-Seq_Bcells_Human0.83774113
89SPI1_20517297_ChIP-Seq_HL60_Human0.83760512
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82322241
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80714428
92TFEB_21752829_ChIP-Seq_HELA_Human0.80130364
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79585124
94* GATA3_26560356_Chip-Seq_TH1_Human0.76369978
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.75219413
96ZNF274_21170338_ChIP-Seq_K562_Hela0.74843862
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73810569
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73144650
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72003043
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.71984725

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.78487618
2MP0003724_increased_susceptibility_to3.72406481
3MP0003303_peritoneal_inflammation3.45038408
4MP0005671_abnormal_response_to3.43168952
5MP0001800_abnormal_humoral_immune3.19707863
6MP0003436_decreased_susceptibility_to3.19700978
7MP0009785_altered_susceptibility_to3.06772118
8MP0005000_abnormal_immune_tolerance3.01027695
9MP0002148_abnormal_hypersensitivity_rea2.99301603
10MP0002419_abnormal_innate_immunity2.96045670
11MP0005387_immune_system_phenotype2.88587964
12MP0001790_abnormal_immune_system2.88587964
13MP0005025_abnormal_response_to2.82850448
14MP0000685_abnormal_immune_system2.81390228
15MP0002452_abnormal_antigen_presenting2.75998457
16MP0002723_abnormal_immune_serum2.72357265
17MP0006082_CNS_inflammation2.56851224
18MP0002420_abnormal_adaptive_immunity2.52826079
19MP0001819_abnormal_immune_cell2.50310712
20MP0009278_abnormal_bone_marrow2.30985196
21MP0000569_abnormal_digit_pigmentation2.13483035
22MP0001545_abnormal_hematopoietic_system1.99635406
23MP0005397_hematopoietic_system_phenotyp1.99635406
24MP0000716_abnormal_immune_system1.94751781
25MP0002166_altered_tumor_susceptibility1.93951880
26MP0002398_abnormal_bone_marrow1.93898379
27MP0005464_abnormal_platelet_physiology1.93431733
28MP0003172_abnormal_lysosome_physiology1.88623094
29MP0001845_abnormal_inflammatory_respons1.84892540
30MP0009764_decreased_sensitivity_to1.81801048
31MP0003763_abnormal_thymus_physiology1.80675589
32MP0002405_respiratory_system_inflammati1.77724036
33MP0010155_abnormal_intestine_physiology1.73394520
34MP0000689_abnormal_spleen_morphology1.67555113
35MP0009333_abnormal_splenocyte_physiolog1.65762400
36MP0002396_abnormal_hematopoietic_system1.59203056
37MP0003300_gastrointestinal_ulcer1.56765869
38MP0002429_abnormal_blood_cell1.55777770
39MP0008469_abnormal_protein_level1.55748199
40MP0001533_abnormal_skeleton_physiology1.55505410
41MP0002722_abnormal_immune_system1.53092077
42MP0002006_tumorigenesis1.48410067
43MP0000015_abnormal_ear_pigmentation1.43751268
44MP0004947_skin_inflammation1.37442524
45MP0003075_altered_response_to1.34980617
46MP0001853_heart_inflammation1.34223292
47MP0000465_gastrointestinal_hemorrhage1.32917162
48MP0003183_abnormal_peptide_metabolism1.27647096
49MP0005310_abnormal_salivary_gland1.24074972
50MP0005075_abnormal_melanosome_morpholog1.18834874
51MP0003866_abnormal_defecation1.18719649
52MP0005058_abnormal_lysosome_morphology1.17564556
53MP0003828_pulmonary_edema1.15001699
54MP0000703_abnormal_thymus_morphology1.13552429
55MP0003191_abnormal_cellular_cholesterol1.09846726
56MP0004883_abnormal_blood_vessel1.07833253
57MP0005174_abnormal_tail_pigmentation1.07518896
58MP0003806_abnormal_nucleotide_metabolis1.03948759
59MP0002132_abnormal_respiratory_system1.02255862
60MP0004808_abnormal_hematopoietic_stem1.02214909
61MP0008057_abnormal_DNA_replication1.00977146
62MP0001873_stomach_inflammation0.97549614
63MP0004381_abnormal_hair_follicle0.95878527
64MP0000858_altered_metastatic_potential0.95633522
65MP0008877_abnormal_DNA_methylation0.94985911
66MP0005166_decreased_susceptibility_to0.94249332
67MP0000343_altered_response_to0.93849931
68MP0001986_abnormal_taste_sensitivity0.93405389
69MP0001663_abnormal_digestive_system0.91520668
70MP0002998_abnormal_bone_remodeling0.90988530
71MP0009763_increased_sensitivity_to0.89976289
72MP0002138_abnormal_hepatobiliary_system0.89266966
73MP0003690_abnormal_glial_cell0.88334569
74MP0008260_abnormal_autophagy0.87979369
75MP0002009_preneoplasia0.86437514
76MP0005164_abnormal_response_to0.81727409
77MP0003195_calcinosis0.79551292
78MP0005451_abnormal_body_composition0.78944096
79MP0000604_amyloidosis0.76582959
80MP0002277_abnormal_respiratory_mucosa0.74381814
81MP0005167_abnormal_blood-brain_barrier0.73975593
82MP0003656_abnormal_erythrocyte_physiolo0.73863055
83MP0009765_abnormal_xenobiotic_induced0.73440393
84MP0003787_abnormal_imprinting0.71296847
85MP0003646_muscle_fatigue0.71211667
86MP0002019_abnormal_tumor_incidence0.70125419
87MP0000249_abnormal_blood_vessel0.65839900
88MP0003448_altered_tumor_morphology0.65195077
89MP0002095_abnormal_skin_pigmentation0.65016720
90MP0001764_abnormal_homeostasis0.64265310
91MP0005645_abnormal_hypothalamus_physiol0.61185456
92MP0002693_abnormal_pancreas_physiology0.59157655
93MP0002928_abnormal_bile_duct0.58342845
94MP0008873_increased_physiological_sensi0.57494734
95MP0000371_diluted_coat_color0.57361481
96MP0005376_homeostasis/metabolism_phenot0.55074546
97MP0001851_eye_inflammation0.54511527
98MP0005084_abnormal_gallbladder_morpholo0.54044855
99MP0005319_abnormal_enzyme/_coenzyme0.52951461
100MP0003252_abnormal_bile_duct0.52039655

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.32769476
2Recurrent cutaneous fungal infections (HP:0011370)5.09639174
3Chronic mucocutaneous candidiasis (HP:0002728)5.09639174
4Recurrent abscess formation (HP:0002722)5.07443221
5Elevated erythrocyte sedimentation rate (HP:0003565)4.82737200
6Myositis (HP:0100614)4.80269997
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.57404175
8Retrobulbar optic neuritis (HP:0100654)4.56332495
9Optic neuritis (HP:0100653)4.56332495
10Recurrent fungal infections (HP:0002841)4.54130217
11Orchitis (HP:0100796)4.50647891
12Stomatitis (HP:0010280)4.48056835
13Eczematoid dermatitis (HP:0000976)4.30577570
14Meningitis (HP:0001287)4.29346849
15Mediastinal lymphadenopathy (HP:0100721)4.23013169
16Recurrent skin infections (HP:0001581)4.21640651
17Abnormality of macrophages (HP:0004311)3.95573242
18Panhypogammaglobulinemia (HP:0003139)3.92854663
19Agammaglobulinemia (HP:0004432)3.86076049
20Vasculitis (HP:0002633)3.78183787
21Encephalitis (HP:0002383)3.70443220
22Recurrent gram-negative bacterial infections (HP:0005420)3.64707863
23Obstructive lung disease (HP:0006536)3.62314628
24Chronic obstructive pulmonary disease (HP:0006510)3.62314628
25Recurrent viral infections (HP:0004429)3.57391607
26Pulmonary infiltrates (HP:0002113)3.44818135
27Gastrointestinal infarctions (HP:0005244)3.44689588
28Hemoptysis (HP:0002105)3.42634898
29Abnormality of B cell number (HP:0010975)3.21695611
30Keratoconjunctivitis sicca (HP:0001097)3.14793852
31Abnormality of the prostate (HP:0008775)3.13192300
32Urticaria (HP:0001025)3.02439124
33Abnormality of T cell physiology (HP:0011840)2.99459697
34Keratoconjunctivitis (HP:0001096)2.99273587
35Colitis (HP:0002583)2.99022349
36Abnormality of T cells (HP:0002843)2.95377686
37Autoimmune thrombocytopenia (HP:0001973)2.94950631
38Chest pain (HP:0100749)2.89299282
39Abnormality of T cell number (HP:0011839)2.89293336
40Autoimmune hemolytic anemia (HP:0001890)2.86928456
41Leukocytosis (HP:0001974)2.85197233
42Granulocytopenia (HP:0001913)2.82543449
43Arterial thrombosis (HP:0004420)2.79094573
44B lymphocytopenia (HP:0010976)2.74682941
45Increased cerebral lipofuscin (HP:0011813)2.74539783
46T lymphocytopenia (HP:0005403)2.72496588
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.67979814
48Inflammation of the large intestine (HP:0002037)2.65503735
49Eosinophilia (HP:0001880)2.64881520
50Amyloidosis (HP:0011034)2.61049698
51Cellulitis (HP:0100658)2.60153692
52Pulmonary embolism (HP:0002204)2.55190267
53Abnormality of the pleura (HP:0002103)2.53717710
54Gangrene (HP:0100758)2.52577873
55Increased IgM level (HP:0003496)2.50329152
56Abnormality of glycolipid metabolism (HP:0010969)2.49013659
57Abnormality of liposaccharide metabolism (HP:0010968)2.49013659
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.49013659
59Gastrointestinal inflammation (HP:0004386)2.47175693
60Chronic otitis media (HP:0000389)2.38309989
61Gingivitis (HP:0000230)2.37081457
62Spontaneous hematomas (HP:0007420)2.36498561
63Recurrent sinusitis (HP:0011108)2.36497177
64Hypochromic anemia (HP:0001931)2.31217304
65Gastrointestinal stroma tumor (HP:0100723)2.29858448
66Skin rash (HP:0000988)2.27898205
67Osteomyelitis (HP:0002754)2.27893879
68IgG deficiency (HP:0004315)2.26649073
69Episodic fever (HP:0001954)2.23771456
70Recurrent bronchitis (HP:0002837)2.23574620
71Abnormality of eosinophils (HP:0001879)2.23368854
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23196602
73Anorexia (HP:0002039)2.23135111
74Prostate neoplasm (HP:0100787)2.22397892
75Polyneuropathy (HP:0001271)2.21715799
76Viral hepatitis (HP:0006562)2.18614355
77Increased IgE level (HP:0003212)2.17758990
78Epistaxis (HP:0000421)2.17561418
79Recurrent pneumonia (HP:0006532)2.16518613
80Prolonged bleeding time (HP:0003010)2.14714126
81Vacuolated lymphocytes (HP:0001922)2.11791571
82Hypergammaglobulinemia (HP:0010702)2.11139103
83IgM deficiency (HP:0002850)2.11043144
84Pustule (HP:0200039)2.09917669
85Acute hepatic failure (HP:0006554)2.09503201
86Recurrent lower respiratory tract infections (HP:0002783)2.08773660
87Sepsis (HP:0100806)2.08354995
88Lymphopenia (HP:0001888)2.08014571
89Abnormality of the endocardium (HP:0004306)2.06646693
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.02269976
91Severe combined immunodeficiency (HP:0004430)1.95896325
92Cheilitis (HP:0100825)1.94199937
93Amaurosis fugax (HP:0100576)1.93281133
94Gingival bleeding (HP:0000225)1.92600348
95Chronic diarrhea (HP:0002028)1.92514669
96Fatigue (HP:0012378)1.91295168
97Abnormality of the peritoneum (HP:0002585)1.88547173
98Stomach cancer (HP:0012126)1.87926433
99Abnormality of male internal genitalia (HP:0000022)1.87788867
100Verrucae (HP:0200043)1.86181880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.98503467
2MAP4K13.63239237
3BLK3.46319431
4KIT3.04080362
5FES2.61384312
6SYK2.60925801
7IRAK42.59636644
8TYK22.54152891
9BMPR22.44302906
10MAP3K142.39458767
11TAOK32.34666184
12IKBKE2.18848796
13CSF1R2.16605988
14TXK2.16541054
15ERN12.11738817
16TBK12.02680545
17FRK1.93194978
18TEC1.92902997
19BTK1.92724593
20CSK1.87853490
21IKBKB1.87644302
22LYN1.78509247
23TNK21.77516831
24JAK31.76998912
25GRK61.69860364
26MAP2K31.63801259
27MATK1.54006877
28ZAP701.52437316
29HCK1.43089148
30ITK1.42719429
31ADRBK21.37753868
32JAK11.36260405
33LCK1.30708247
34FGR1.27935155
35MAP3K131.25182201
36PIK3CG1.24402241
37JAK21.21707829
38PINK11.21132313
39TESK21.16041919
40GRK71.11956326
41TLK11.05794565
42CDK191.02618328
43SCYL20.99717791
44FLT30.94574951
45IRAK10.82080501
46PRKCQ0.75623156
47MARK30.74049509
48PDK10.73379735
49CDK40.70916919
50PIM10.68037675
51MAP2K60.66982408
52MAPK70.63156426
53HIPK20.62549281
54STK100.62413640
55CDK60.58976104
56IRAK20.58644046
57DAPK20.58526937
58ABL10.57966259
59TGFBR20.57821617
60YES10.56307280
61CHUK0.54778583
62MAP3K110.54695104
63MAPK120.54567286
64ZAK0.54187435
65PTK2B0.53464439
66RPS6KA60.51341875
67RPS6KL10.48513379
68RPS6KC10.48513379
69MAPK110.46826079
70FGFR30.46690778
71STK110.43831974
72MAP3K10.43561098
73NEK90.43207770
74ADRBK10.42758034
75IRAK30.40704067
76PRPF4B0.39045155
77MAPK40.38955641
78MAP3K50.38714569
79PRKCD0.38594256
80PDPK10.37614212
81MAP3K30.37146760
82TAOK10.34447987
83MAP4K20.34156067
84OXSR10.33476492
85TRPM70.32759130
86FYN0.31918554
87EGFR0.31898935
88CAMKK20.31803354
89EIF2AK30.31798224
90MAPKAPK20.30678521
91GRK50.29162904
92SIK30.28062116
93MAPK30.27183548
94RPS6KA40.26761136
95GRK10.26126664
96ACVR1B0.25779699
97RPS6KA50.24673007
98SIK20.23085201
99LRRK20.22924772
100IGF1R0.22627610

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.46947969
2Allograft rejection_Homo sapiens_hsa053304.16694014
3Graft-versus-host disease_Homo sapiens_hsa053323.85991597
4Autoimmune thyroid disease_Homo sapiens_hsa053203.84303669
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.72984630
6Staphylococcus aureus infection_Homo sapiens_hsa051503.29311236
7Type I diabetes mellitus_Homo sapiens_hsa049403.27560473
8Leishmaniasis_Homo sapiens_hsa051403.27443681
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.98866955
10Antigen processing and presentation_Homo sapiens_hsa046122.59329121
11Primary immunodeficiency_Homo sapiens_hsa053402.58699177
12Tuberculosis_Homo sapiens_hsa051522.19949947
13Rheumatoid arthritis_Homo sapiens_hsa053232.12202430
14Viral myocarditis_Homo sapiens_hsa054162.06391784
15Osteoclast differentiation_Homo sapiens_hsa043802.06160362
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95048710
17B cell receptor signaling pathway_Homo sapiens_hsa046621.80420167
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80401010
19Hematopoietic cell lineage_Homo sapiens_hsa046401.80393773
20Influenza A_Homo sapiens_hsa051641.75435340
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.65396381
22Herpes simplex infection_Homo sapiens_hsa051681.60860982
23Toxoplasmosis_Homo sapiens_hsa051451.53233992
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51056014
25Measles_Homo sapiens_hsa051621.47640655
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44725062
27Legionellosis_Homo sapiens_hsa051341.43615290
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41611239
29Phagosome_Homo sapiens_hsa041451.29824906
30Systemic lupus erythematosus_Homo sapiens_hsa053221.29567057
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24286997
32Malaria_Homo sapiens_hsa051441.22128686
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16338932
34Chemokine signaling pathway_Homo sapiens_hsa040621.10439593
35Other glycan degradation_Homo sapiens_hsa005111.09731324
36African trypanosomiasis_Homo sapiens_hsa051431.05404352
37Pertussis_Homo sapiens_hsa051331.03533881
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.03275907
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96021668
40T cell receptor signaling pathway_Homo sapiens_hsa046600.95895494
41TNF signaling pathway_Homo sapiens_hsa046680.90822740
42Lysosome_Homo sapiens_hsa041420.88569172
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87625359
44Platelet activation_Homo sapiens_hsa046110.75106139
45Epstein-Barr virus infection_Homo sapiens_hsa051690.74499296
46Hepatitis B_Homo sapiens_hsa051610.72774776
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71404896
48Shigellosis_Homo sapiens_hsa051310.71075387
49Salmonella infection_Homo sapiens_hsa051320.69184489
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67647839
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64554462
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63045305
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62680020
54Acute myeloid leukemia_Homo sapiens_hsa052210.61917072
55Hepatitis C_Homo sapiens_hsa051600.61141950
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58431954
57Apoptosis_Homo sapiens_hsa042100.54373132
58Ether lipid metabolism_Homo sapiens_hsa005650.44820645
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43440223
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.41381586
61Regulation of autophagy_Homo sapiens_hsa041400.41021759
62Viral carcinogenesis_Homo sapiens_hsa052030.40585090
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38110932
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.36020869
65HTLV-I infection_Homo sapiens_hsa051660.35546279
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.34271797
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33133717
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31347621
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30917097
70Homologous recombination_Homo sapiens_hsa034400.30183133
71Linoleic acid metabolism_Homo sapiens_hsa005910.27646096
72Arachidonic acid metabolism_Homo sapiens_hsa005900.27597913
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.25333110
74Collecting duct acid secretion_Homo sapiens_hsa049660.24983245
75Prolactin signaling pathway_Homo sapiens_hsa049170.24208102
76Non-small cell lung cancer_Homo sapiens_hsa052230.22867312
77Dorso-ventral axis formation_Homo sapiens_hsa043200.21947574
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.20848118
79Fanconi anemia pathway_Homo sapiens_hsa034600.20202625
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19297280
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18144341
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15773771
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.14710658
84VEGF signaling pathway_Homo sapiens_hsa043700.13893254
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13275651
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10455817
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09082552
88Olfactory transduction_Homo sapiens_hsa047400.09033091
89Phototransduction_Homo sapiens_hsa047440.08950930
90Pancreatic cancer_Homo sapiens_hsa052120.08923140
91HIF-1 signaling pathway_Homo sapiens_hsa040660.08774496
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.06543456
93Endocytosis_Homo sapiens_hsa041440.06257942
94Nitrogen metabolism_Homo sapiens_hsa009100.04843229
95MAPK signaling pathway_Homo sapiens_hsa040100.04099563
96Type II diabetes mellitus_Homo sapiens_hsa049300.03812237
97Renin-angiotensin system_Homo sapiens_hsa046140.02222456
98mTOR signaling pathway_Homo sapiens_hsa041500.02162566
99Tryptophan metabolism_Homo sapiens_hsa003800.01962327
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.01916430

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