CXCR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)9.14665493
2negative T cell selection (GO:0043383)9.12787890
3positive thymic T cell selection (GO:0045059)8.88928801
4negative thymic T cell selection (GO:0045060)8.74788142
5positive T cell selection (GO:0043368)7.96904419
6regulation of gamma-delta T cell differentiation (GO:0045586)7.23018236
7thymic T cell selection (GO:0045061)6.81897742
8regulation of B cell receptor signaling pathway (GO:0050855)6.76757981
9positive regulation of isotype switching (GO:0045830)6.60908078
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.56992856
11regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)6.56488537
12cellular response to interleukin-15 (GO:0071350)6.52838817
13regulation of gamma-delta T cell activation (GO:0046643)6.52201734
14response to interleukin-15 (GO:0070672)6.14998165
15leukocyte aggregation (GO:0070486)6.12721294
16positive regulation of DNA recombination (GO:0045911)6.05636596
17T cell selection (GO:0045058)6.04865106
18positive regulation of natural killer cell mediated immunity (GO:0002717)6.03313823
19positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.03313823
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.84563532
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.84563532
22regulation of natural killer cell mediated immunity (GO:0002715)5.72499782
23regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.72499782
24negative regulation of T cell mediated immunity (GO:0002710)5.55055993
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44352824
26cytidine deamination (GO:0009972)5.41631225
27cytidine metabolic process (GO:0046087)5.41631225
28cytidine catabolic process (GO:0006216)5.41631225
29regulation of isotype switching (GO:0045191)5.29500751
30positive regulation of alpha-beta T cell proliferation (GO:0046641)5.27915502
31positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.18735101
32positive regulation of immunoglobulin mediated immune response (GO:0002891)5.12729120
33positive regulation of B cell mediated immunity (GO:0002714)5.12729120
34* T cell migration (GO:0072678)5.09439689
35positive regulation of humoral immune response (GO:0002922)5.09028865
36regulation of leukocyte mediated cytotoxicity (GO:0001910)5.04450432
37antigen processing and presentation of endogenous antigen (GO:0019883)5.03103481
38pyrimidine ribonucleoside catabolic process (GO:0046133)5.02718690
39positive regulation of cell killing (GO:0031343)4.96875454
40T cell costimulation (GO:0031295)4.95274425
41T cell receptor signaling pathway (GO:0050852)4.95148908
42interferon-gamma production (GO:0032609)4.88829245
43lymphocyte costimulation (GO:0031294)4.86831176
44regulation of alpha-beta T cell proliferation (GO:0046640)4.84129780
45regulation of cell killing (GO:0031341)4.82587212
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.60793760
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.57137194
48regulation of immunoglobulin mediated immune response (GO:0002889)4.54414363
49negative regulation of lymphocyte mediated immunity (GO:0002707)4.48718694
50DNA deamination (GO:0045006)4.43406183
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.41330990
52regulation of T cell tolerance induction (GO:0002664)4.40407445
53regulation of B cell mediated immunity (GO:0002712)4.40059562
54sequestering of actin monomers (GO:0042989)4.38074046
55antigen receptor-mediated signaling pathway (GO:0050851)4.30621104
56positive regulation of B cell differentiation (GO:0045579)4.28657216
57regulation of T cell mediated cytotoxicity (GO:0001914)4.21640550
58positive regulation of immunoglobulin production (GO:0002639)4.17971072
59activated T cell proliferation (GO:0050798)4.17774153
60regulation of B cell differentiation (GO:0045577)4.13777858
61heterotypic cell-cell adhesion (GO:0034113)4.06327289
62leukocyte cell-cell adhesion (GO:0007159)4.03150202
63immunoglobulin mediated immune response (GO:0016064)3.96139903
64B cell receptor signaling pathway (GO:0050853)3.82987838
65positive regulation of lymphocyte mediated immunity (GO:0002708)3.82142712
66regulation of immunoglobulin production (GO:0002637)3.81893648
67regulation of T cell receptor signaling pathway (GO:0050856)3.74521597
68positive regulation of T cell mediated cytotoxicity (GO:0001916)3.74139830
69cellular response to type I interferon (GO:0071357)3.66595824
70type I interferon signaling pathway (GO:0060337)3.66595824
71positive regulation of lamellipodium assembly (GO:0010592)3.64548077
72response to type I interferon (GO:0034340)3.63577959
73regulation of lymphocyte mediated immunity (GO:0002706)3.61195288
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.58443543
75regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.57916596
76natural killer cell activation (GO:0030101)3.57836700
77regulation of response to interferon-gamma (GO:0060330)3.56497746
78negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.52404420
79tolerance induction (GO:0002507)3.50695077
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.49408343
81regulation of interleukin-12 biosynthetic process (GO:0045075)3.48793839
82positive regulation of tolerance induction (GO:0002645)3.48698349
83T cell differentiation (GO:0030217)3.45305672
84regulation of interleukin-2 biosynthetic process (GO:0045076)3.39334551
85B cell mediated immunity (GO:0019724)3.38308691
86regulation of response to tumor cell (GO:0002834)3.36518612
87positive regulation of response to tumor cell (GO:0002836)3.36518612
88positive regulation of immune response to tumor cell (GO:0002839)3.36518612
89regulation of immune response to tumor cell (GO:0002837)3.36518612
90regulation of T cell chemotaxis (GO:0010819)3.34101863
91positive regulation of T cell chemotaxis (GO:0010820)3.34101863
92negative regulation of leukocyte mediated immunity (GO:0002704)3.33993525
93positive regulation of interleukin-4 production (GO:0032753)3.32872732
94* lymphocyte migration (GO:0072676)3.32687668
95negative regulation of viral genome replication (GO:0045071)3.29186225
96positive regulation of calcium-mediated signaling (GO:0050850)3.28834826
97negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.27986642
98positive regulation of granulocyte differentiation (GO:0030854)3.25678390
99dendritic cell chemotaxis (GO:0002407)3.25499970
100alpha-beta T cell differentiation involved in immune response (GO:0002293)3.25407003
101alpha-beta T cell activation involved in immune response (GO:0002287)3.25407003
102T cell differentiation involved in immune response (GO:0002292)3.25407003
103positive regulation of leukocyte mediated immunity (GO:0002705)3.25215555
104positive regulation of T cell mediated immunity (GO:0002711)3.23710143
105regulation of alpha-beta T cell activation (GO:0046634)3.21230429
106T cell proliferation (GO:0042098)3.21022515
107antigen processing and presentation via MHC class Ib (GO:0002475)3.20695733
108negative regulation of T cell apoptotic process (GO:0070233)3.19978105
109positive regulation of interleukin-2 production (GO:0032743)3.19339450
110detection of bacterium (GO:0016045)3.18736597
111* lymphocyte chemotaxis (GO:0048247)3.18272871
112myeloid dendritic cell activation (GO:0001773)3.17996286
113mast cell activation (GO:0045576)3.17978963
114T cell activation (GO:0042110)3.17689194
115positive regulation of defense response to virus by host (GO:0002230)3.15754684
116NIK/NF-kappaB signaling (GO:0038061)3.14842304
117cellular defense response (GO:0006968)3.14712293
118negative regulation of adaptive immune response (GO:0002820)3.12251051
119negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.12121498
120interferon-gamma-mediated signaling pathway (GO:0060333)3.10855902
121regulation of T cell mediated immunity (GO:0002709)3.09699414
122positive regulation of T cell activation (GO:0050870)3.09680992
123regulation of defense response to virus by virus (GO:0050690)3.08361857
124regulation of type I interferon-mediated signaling pathway (GO:0060338)3.07871282
125regulation of tolerance induction (GO:0002643)3.07830792
126regulation of lymphocyte chemotaxis (GO:1901623)3.07035412
127immune response-activating cell surface receptor signaling pathway (GO:0002429)3.06790197
128negative regulation of T cell receptor signaling pathway (GO:0050860)3.03377159
129Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03364775
130regulation of regulatory T cell differentiation (GO:0045589)3.01460095
131negative regulation of alpha-beta T cell activation (GO:0046636)2.99791314
132positive regulation of lymphocyte migration (GO:2000403)2.99518071
133detection of other organism (GO:0098543)2.98799365
134negative regulation of cell killing (GO:0031342)12.6897926
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)12.6897926
136regulation of isotype switching to IgG isotypes (GO:0048302)10.0487576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.66114291
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.82031901
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.71142087
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.46819054
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.45293248
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.25248150
7RUNX_20019798_ChIP-Seq_JUKART_Human4.13739649
8STAT4_19710469_ChIP-ChIP_TH1__Mouse4.09023839
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.64775563
10MYB_26560356_Chip-Seq_TH2_Human3.37319009
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.24809020
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10051037
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.02007194
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95542149
15MAF_26560356_Chip-Seq_TH1_Human2.95540174
16MYB_26560356_Chip-Seq_TH1_Human2.75886506
17UTX_26944678_Chip-Seq_JUKART_Human2.72794265
18MYC_22102868_ChIP-Seq_BL_Human2.69205710
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60564692
20E2F7_22180533_ChIP-Seq_HELA_Human2.43681604
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.32667702
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20385769
23GATA3_27048872_Chip-Seq_THYMUS_Human2.11217786
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.07961191
25* RUNX1_22412390_ChIP-Seq_EML_Mouse2.02482464
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.00461390
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00128027
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99554997
29* SPI1_23547873_ChIP-Seq_NB4_Human1.96831022
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96481686
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91966827
32MAF_26560356_Chip-Seq_TH2_Human1.89558925
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.89347791
34* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85686772
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85209895
36VDR_21846776_ChIP-Seq_THP-1_Human1.77423444
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73862806
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69969218
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66017022
40VDR_24763502_ChIP-Seq_THP-1_Human1.53544322
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53044625
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52109038
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51958145
44GATA3_26560356_Chip-Seq_TH2_Human1.48742049
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47977456
46TCF7_22412390_ChIP-Seq_EML_Mouse1.46347117
47SCL_19346495_ChIP-Seq_HPC-7_Human1.44916881
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44853150
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42434826
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41544994
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38507416
52SPI1_23127762_ChIP-Seq_K562_Human1.30826341
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29923400
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29538006
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29099053
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27407237
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26596588
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22887414
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21759254
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21062712
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.20747225
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20441191
63BCL6_27268052_Chip-Seq_Bcells_Human1.19935687
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16871915
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14499704
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14388339
67PU_27001747_Chip-Seq_BMDM_Mouse1.13682163
68* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10674513
69KDM2B_26808549_Chip-Seq_DND41_Human1.10165013
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09155686
71VDR_23849224_ChIP-Seq_CD4+_Human1.08856130
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07091880
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06444553
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05612237
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04941726
76BCOR_27268052_Chip-Seq_Bcells_Human1.04278572
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02113800
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99553468
79FOXP3_21729870_ChIP-Seq_TREG_Human0.96316251
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95403813
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91532801
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.90562089
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87790782
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87231244
85VDR_24787735_ChIP-Seq_THP-1_Human0.84681666
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.84510567
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83873336
88FLI1_21867929_ChIP-Seq_CD8_Mouse0.83788139
89SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83628852
90P300_27268052_Chip-Seq_Bcells_Human0.82297125
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81567191
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81395643
93GATA3_26560356_Chip-Seq_TH1_Human0.80984814
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.79438594
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78412544
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77928657
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77657035
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.76379788
99CIITA_25753668_ChIP-Seq_RAJI_Human0.76316691
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.75272161
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74797364
102GATA1_22025678_ChIP-Seq_K562_Human0.74003461
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73869413
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73395014
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71983318
106RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71959033
107TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69753144
108EGR1_19032775_ChIP-ChIP_M12_Human0.68932984
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.68198734
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66745416
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66299914
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.65583605
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.62492853
114LXR_22292898_ChIP-Seq_THP-1_Human0.60541253
115ELK1_19687146_ChIP-ChIP_HELA_Human0.58535602
116SPI1_20517297_ChIP-Seq_HL60_Human0.58463323
117FOXM1_23109430_ChIP-Seq_U2OS_Human0.56724772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.95780486
2MP0006082_CNS_inflammation4.99367812
3* MP0005671_abnormal_response_to4.90434373
4MP0001835_abnormal_antigen_presentation3.61646466
5MP0000685_abnormal_immune_system3.56876855
6* MP0009785_altered_susceptibility_to3.53875928
7MP0001800_abnormal_humoral_immune3.27160545
8MP0005000_abnormal_immune_tolerance3.17009526
9MP0009333_abnormal_splenocyte_physiolog3.03826985
10* MP0002420_abnormal_adaptive_immunity3.00637818
11* MP0001819_abnormal_immune_cell2.95304413
12* MP0002723_abnormal_immune_serum2.92721178
13* MP0002405_respiratory_system_inflammati2.88984388
14* MP0005025_abnormal_response_to2.82973321
15MP0005387_immune_system_phenotype2.81879696
16MP0001790_abnormal_immune_system2.81879696
17MP0002398_abnormal_bone_marrow2.75321559
18MP0001873_stomach_inflammation2.63854324
19* MP0002452_abnormal_antigen_presenting2.59899088
20MP0002166_altered_tumor_susceptibility2.53611467
21MP0000716_abnormal_immune_system2.48853475
22MP0003724_increased_susceptibility_to2.46161510
23MP0002132_abnormal_respiratory_system2.45909000
24MP0000703_abnormal_thymus_morphology2.43497330
25MP0000858_altered_metastatic_potential2.38924141
26MP0002148_abnormal_hypersensitivity_rea2.28296952
27MP0002722_abnormal_immune_system2.27153260
28MP0002933_joint_inflammation2.22939047
29MP0003866_abnormal_defecation2.21347869
30MP0000689_abnormal_spleen_morphology2.21220670
31MP0002006_tumorigenesis2.16070074
32MP0004947_skin_inflammation2.14671468
33MP0010155_abnormal_intestine_physiology2.09098912
34MP0003436_decreased_susceptibility_to2.08231974
35* MP0002419_abnormal_innate_immunity2.02485364
36MP0002429_abnormal_blood_cell1.98335980
37MP0002396_abnormal_hematopoietic_system1.75177296
38* MP0001845_abnormal_inflammatory_respons1.72656594
39MP0003300_gastrointestinal_ulcer1.61966545
40MP0005464_abnormal_platelet_physiology1.59679263
41MP0001851_eye_inflammation1.58280432
42MP0004510_myositis1.36316191
43MP0002998_abnormal_bone_remodeling1.35975945
44* MP0003448_altered_tumor_morphology1.34509726
45* MP0002019_abnormal_tumor_incidence1.30119392
46MP0002138_abnormal_hepatobiliary_system1.27829655
47* MP0008469_abnormal_protein_level1.25567502
48MP0004381_abnormal_hair_follicle1.23288839
49MP0001853_heart_inflammation1.22708846
50MP0001533_abnormal_skeleton_physiology1.18846366
51MP0002277_abnormal_respiratory_mucosa1.12418432
52MP0003183_abnormal_peptide_metabolism1.03420236
53MP0001986_abnormal_taste_sensitivity0.99623953
54MP0005310_abnormal_salivary_gland0.98558557
55MP0001348_abnormal_lacrimal_gland0.98505036
56MP0000465_gastrointestinal_hemorrhage0.95958503
57MP0005645_abnormal_hypothalamus_physiol0.95702140
58MP0010352_gastrointestinal_tract_polyps0.94010503
59* MP0003045_fibrosis0.93951934
60MP0000920_abnormal_myelination0.91837188
61MP0009763_increased_sensitivity_to0.87180951
62MP0005023_abnormal_wound_healing0.85709766
63MP0000490_abnormal_crypts_of0.83295954
64MP0003693_abnormal_embryo_hatching0.82372621
65MP0002163_abnormal_gland_morphology0.81994661
66* MP0005166_decreased_susceptibility_to0.80434445
67MP0005075_abnormal_melanosome_morpholog0.77934493
68MP0004957_abnormal_blastocyst_morpholog0.77713721
69MP0008007_abnormal_cellular_replicative0.76161383
70MP0009764_decreased_sensitivity_to0.76068827
71MP0003077_abnormal_cell_cycle0.75370611
72MP0009765_abnormal_xenobiotic_induced0.73559988
73MP0001243_abnormal_dermal_layer0.72607848
74MP0005058_abnormal_lysosome_morphology0.72246341
75MP0000343_altered_response_to0.72188370
76MP0003172_abnormal_lysosome_physiology0.71682827
77MP0002009_preneoplasia0.69917883
78MP0000604_amyloidosis0.66484619
79MP0000609_abnormal_liver_physiology0.65855484
80MP0008569_lethality_at_weaning0.65754014
81MP0000015_abnormal_ear_pigmentation0.65202249
82MP0004883_abnormal_blood_vessel0.64209367
83* MP0002136_abnormal_kidney_physiology0.63267789
84MP0001919_abnormal_reproductive_system0.60076399
85MP0003075_altered_response_to0.59833454
86MP0003453_abnormal_keratinocyte_physiol0.58955792
87MP0003786_premature_aging0.56466301
88MP0004808_abnormal_hematopoietic_stem0.56309333
89MP0003795_abnormal_bone_structure0.56215505
90MP0001191_abnormal_skin_condition0.55884003
91MP0002693_abnormal_pancreas_physiology0.52968666
92MP0000477_abnormal_intestine_morphology0.52789198
93MP0003690_abnormal_glial_cell0.52558968
94MP0000613_abnormal_salivary_gland0.52382774
95MP0003806_abnormal_nucleotide_metabolis0.49059899
96MP0003303_peritoneal_inflammation0.48844150
97MP0003191_abnormal_cellular_cholesterol0.47065859
98MP0001765_abnormal_ion_homeostasis0.45787590
99MP0008058_abnormal_DNA_repair0.45258312
100MP0005379_endocrine/exocrine_gland_phen0.44798682
101MP0003329_amyloid_beta_deposits0.43687589
102MP0001542_abnormal_bone_strength0.42842749
103MP0009384_cardiac_valve_regurgitation0.41241908
104MP0002095_abnormal_skin_pigmentation0.40538440
105MP0003252_abnormal_bile_duct0.40428816
106MP0010234_abnormal_vibrissa_follicle0.40222954
107MP0002083_premature_death0.39962831
108MP0008057_abnormal_DNA_replication0.39832491
109MP0001881_abnormal_mammary_gland0.39657637
110MP0008872_abnormal_physiological_respon0.39425294
111MP0008961_abnormal_basal_metabolism0.38236266
112MP0000249_abnormal_blood_vessel0.37613666
113* MP0009642_abnormal_blood_homeostasis0.37074775
114MP0008873_increased_physiological_sensi0.36996784
115* MP0009643_abnormal_urine_homeostasis0.36245459
116MP0001216_abnormal_epidermal_layer0.35224085
117MP0001663_abnormal_digestive_system0.35070139
118MP0005451_abnormal_body_composition0.34655492
119MP0010094_abnormal_chromosome_stability0.34324661
120MP0005076_abnormal_cell_differentiation0.34242793
121MP0005390_skeleton_phenotype0.34177171
122MP0005164_abnormal_response_to0.33467822
123MP0002135_abnormal_kidney_morphology0.32523090
124MP0004145_abnormal_muscle_electrophysio0.32257102
125MP0005397_hematopoietic_system_phenotyp0.32153751
126MP0008260_abnormal_autophagy0.31337533
127MP0001501_abnormal_sleep_pattern0.31259681

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.65930308
2Abnormality of T cell number (HP:0011839)9.29460213
3Severe combined immunodeficiency (HP:0004430)7.25388662
4Combined immunodeficiency (HP:0005387)6.79557420
5Abnormality of T cells (HP:0002843)6.16521221
6Nasal polyposis (HP:0100582)6.02055498
7Recurrent bronchitis (HP:0002837)5.31499423
8Stomatitis (HP:0010280)5.19234420
9Increased IgM level (HP:0003496)4.96888683
10Thyroiditis (HP:0100646)4.95036697
11Abnormality of the nasal mucosa (HP:0000433)4.91227289
12Myositis (HP:0100614)4.84585663
13IgG deficiency (HP:0004315)4.80356403
14Abnormality of macrophages (HP:0004311)4.39256877
15Elevated erythrocyte sedimentation rate (HP:0003565)4.38609603
16Optic neuritis (HP:0100653)4.31026259
17Retrobulbar optic neuritis (HP:0100654)4.31026259
18Abnormality of eosinophils (HP:0001879)4.10725183
19Recurrent fungal infections (HP:0002841)4.09916389
20Eczematoid dermatitis (HP:0000976)4.09071633
21Chronic otitis media (HP:0000389)4.08510996
22Recurrent cutaneous fungal infections (HP:0011370)4.02697350
23Chronic mucocutaneous candidiasis (HP:0002728)4.02697350
24Chronic diarrhea (HP:0002028)3.91512567
25Aplastic anemia (HP:0001915)3.84561509
26Joint swelling (HP:0001386)3.83264556
27Orchitis (HP:0100796)3.78649745
28Hypoplasia of the thymus (HP:0000778)3.78379130
29IgM deficiency (HP:0002850)3.67063806
30Panhypogammaglobulinemia (HP:0003139)3.63124822
31Leukocytosis (HP:0001974)3.62084340
32Autoimmune hemolytic anemia (HP:0001890)3.59496700
33Recurrent abscess formation (HP:0002722)3.57273384
34Recurrent viral infections (HP:0004429)3.40285578
35Gastrointestinal infarctions (HP:0005244)3.33213365
36Lymphopenia (HP:0001888)3.32208087
37Keratoconjunctivitis sicca (HP:0001097)3.26228003
38Abnormality of T cell physiology (HP:0011840)3.23979036
39Abnormality of cells of the lymphoid lineage (HP:0012140)3.21004328
40Pulmonary infiltrates (HP:0002113)3.19814241
41Hemoptysis (HP:0002105)3.15570604
42Meningitis (HP:0001287)3.14235714
43Encephalitis (HP:0002383)3.10686895
44Pustule (HP:0200039)3.06078669
45Vasculitis (HP:0002633)3.01491725
46Hypoproteinemia (HP:0003075)3.00139456
47Bronchitis (HP:0012387)2.97222476
48Keratoconjunctivitis (HP:0001096)2.94196512
49Gastrointestinal stroma tumor (HP:0100723)2.91838884
50Hypergammaglobulinemia (HP:0010702)2.89205966
51IgA deficiency (HP:0002720)2.88733009
52Obstructive lung disease (HP:0006536)2.79951795
53Chronic obstructive pulmonary disease (HP:0006510)2.79951795
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.79759840
55Abnormality of the prostate (HP:0008775)2.78410390
56Recurrent sinusitis (HP:0011108)2.78012879
57Inflammation of the large intestine (HP:0002037)2.72219695
58Urticaria (HP:0001025)2.71171629
59Acute hepatic failure (HP:0006554)2.68919112
60Recurrent skin infections (HP:0001581)2.66872120
61Agammaglobulinemia (HP:0004432)2.66349433
62Mediastinal lymphadenopathy (HP:0100721)2.64847786
63Arterial thrombosis (HP:0004420)2.63880323
64Abnormality of B cell number (HP:0010975)2.59868759
65B lymphocytopenia (HP:0010976)2.59868759
66Eosinophilia (HP:0001880)2.59176343
67Gastrointestinal inflammation (HP:0004386)2.55517282
68Gangrene (HP:0100758)2.53871909
69Pulmonary embolism (HP:0002204)2.52009467
70Renal cortical cysts (HP:0000803)2.47321177
71Lymphoma (HP:0002665)2.44431332
72Colitis (HP:0002583)2.43109392
73Hepatitis (HP:0012115)2.34710952
74Hypochromic anemia (HP:0001931)2.31158403
75Petechiae (HP:0000967)2.30529695
76Thrombocytosis (HP:0001894)2.30430720
77Recurrent bacterial skin infections (HP:0005406)2.29154697
78Anorexia (HP:0002039)2.27363452
79Autoimmune thrombocytopenia (HP:0001973)2.24880486
80Granulocytopenia (HP:0001913)2.24134974
81Spontaneous hematomas (HP:0007420)2.22942017
82Increased IgE level (HP:0003212)2.22320998
83Verrucae (HP:0200043)2.17638434
84Papilloma (HP:0012740)2.17638434
85Frequent falls (HP:0002359)2.17598793
86Abnormality of the fingertips (HP:0001211)2.17531012
87Sepsis (HP:0100806)2.17056808
88Chronic sinusitis (HP:0011109)2.15031440
89Polyneuropathy (HP:0001271)2.09027382
90Glomerulopathy (HP:0100820)2.02507337
91Prolonged bleeding time (HP:0003010)2.02457457
92Recurrent otitis media (HP:0000403)2.00220586
93Cellulitis (HP:0100658)1.99452403
94Chest pain (HP:0100749)1.98606233
95Epistaxis (HP:0000421)1.97008629
96Gingivitis (HP:0000230)1.96615159
97Aplasia/Hypoplasia of the thymus (HP:0010515)1.91785813
98Hypochromic microcytic anemia (HP:0004840)1.91162830
99Ureteral stenosis (HP:0000071)1.90877077
100Gingival bleeding (HP:0000225)1.90430033
101Abnormality of the pleura (HP:0002103)1.89682729
102Restrictive lung disease (HP:0002091)1.88910048
103Basal cell carcinoma (HP:0002671)1.88098506
104Amaurosis fugax (HP:0100576)1.87288673
105Reduced antithrombin III activity (HP:0001976)1.87280302
106Prostate neoplasm (HP:0100787)1.87145788
107Keratitis (HP:0000491)1.85976959
108Arthralgia (HP:0002829)1.84318356
109Diplopia (HP:0000651)1.82944156
110Abnormality of binocular vision (HP:0011514)1.82944156
111Conjugated hyperbilirubinemia (HP:0002908)1.80508253
112Pulmonary fibrosis (HP:0002206)1.80358476
113Microcytic anemia (HP:0001935)1.76507624
114Cheilitis (HP:0100825)1.73677986
115Skin rash (HP:0000988)1.71811776
116Recurrent gram-negative bacterial infections (HP:0005420)1.70895917
117Aortic dissection (HP:0002647)1.69999220
118Abnormal platelet volume (HP:0011876)1.69973016
119Emphysema (HP:0002097)1.69678017
120Ureteral obstruction (HP:0006000)1.69129338
121Abnormality of the pericardium (HP:0001697)1.67731608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.19635635
2MAP4K15.04942165
3ITK4.18360525
4ZAP703.17006630
5IKBKE3.11526438
6JAK33.02393254
7RIPK43.01839464
8JAK13.00333730
9TYK22.97101526
10CSK2.89746628
11FGFR42.84982739
12TESK22.67734264
13STK102.54623223
14TBK12.26734498
15MAP3K122.15668708
16LCK2.11745331
17BUB12.05735843
18FGFR31.88932343
19IRAK41.88447434
20MAP3K141.84653358
21BTK1.84308175
22NLK1.67257204
23KDR1.61729523
24TEC1.61521235
25GRK61.61500218
26MAP3K111.59800847
27ERN11.51742832
28BLK1.48893941
29HCK1.43008797
30MAP2K61.42377969
31MST41.41868595
32SYK1.30660757
33PRKCQ1.28964399
34KIT1.20882722
35PRKCH1.19915469
36PRPF4B1.18650418
37MELK1.13856932
38LYN1.01640128
39NME20.99921431
40LRRK20.98521782
41RPS6KA40.97157874
42CLK10.94545637
43CAMKK20.94282451
44IKBKB0.92025949
45CAMKK10.84548441
46TESK10.83167218
47JAK20.79778232
48ACVR1B0.79114620
49SMG10.76754490
50NEK90.72766361
51FES0.72618251
52MAP3K130.70452628
53CSF1R0.69693979
54FGR0.66089637
55TNK20.65877380
56MAPKAPK30.65351996
57VRK10.62574183
58BMPR20.61459247
59MARK30.60883319
60PIK3CG0.58777038
61SCYL20.57491422
62MAP2K30.56441931
63IRAK10.56427339
64PIM10.56004886
65ADRBK20.54634234
66MAP3K10.54268375
67FYN0.53095033
68TGFBR20.52996540
69INSR0.50037103
70IRAK20.49974024
71TAOK20.49702621
72MAP3K100.48820718
73MAP3K70.47471096
74EPHA30.47458183
75SIK20.46234458
76MAPK110.46071897
77CDK90.45326606
78VRK20.45028942
79MAP3K30.44391510
80IGF1R0.42527261
81MAPKAPK20.41664589
82MAPK70.41599509
83TAOK30.40187580
84MAPK120.39655412
85TYRO30.39462838
86PDK10.39294166
87MAP3K50.39289321
88BCKDK0.39248143
89EPHB10.38287152
90TLK10.36233777
91CDK80.35646567
92CDK40.34240749
93HIPK20.33512436
94RPS6KA50.33344045
95TTN0.32238386
96PDGFRB0.31548211
97CSNK1A1L0.30023824
98MYLK0.29204355
99PRKCD0.27854383
100CHUK0.26115867
101PRKD20.25735712
102STK160.24452928
103TSSK60.23874221
104NUAK10.22537664
105DAPK30.22520872
106ABL10.22306176
107SRC0.22000021
108RAF10.19794163
109ZAK0.19756848
110FGFR10.19448723
111TAOK10.18444704
112MAP2K20.17273412
113MAP3K80.16850803
114GRK70.16299134
115DMPK0.16198816
116EIF2AK30.15797373
117SIK30.15614665
118PKN20.15589754
119MAPK30.15356974
120PRKCB0.15022259
121NME10.14786692
122EEF2K0.13885741
123ALK0.12845660
124PTK60.12744375
125PASK0.12582349
126STK40.11930170
127TGFBR10.11492115
128ILK0.11200352
129CSNK1A10.10402593
130GSK3A0.10314027

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.53132517
2Graft-versus-host disease_Homo sapiens_hsa053325.44149560
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.41042176
4T cell receptor signaling pathway_Homo sapiens_hsa046603.90646484
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.77302572
6Antigen processing and presentation_Homo sapiens_hsa046123.67070842
7Allograft rejection_Homo sapiens_hsa053303.11940577
8Measles_Homo sapiens_hsa051622.72949705
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.32616019
10Viral myocarditis_Homo sapiens_hsa054162.14019330
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.13902081
12Hematopoietic cell lineage_Homo sapiens_hsa046401.82270698
13B cell receptor signaling pathway_Homo sapiens_hsa046621.78425968
14Leishmaniasis_Homo sapiens_hsa051401.77299587
15Autoimmune thyroid disease_Homo sapiens_hsa053201.74715987
16Osteoclast differentiation_Homo sapiens_hsa043801.63488212
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.59093104
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58844265
19Malaria_Homo sapiens_hsa051441.47360242
20Type I diabetes mellitus_Homo sapiens_hsa049401.46435857
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43368642
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42670484
23Herpes simplex infection_Homo sapiens_hsa051681.40614044
24Systemic lupus erythematosus_Homo sapiens_hsa053221.40275295
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38807055
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.31701390
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27699627
28* Chemokine signaling pathway_Homo sapiens_hsa040621.13457416
29* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09008000
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06673478
31Pancreatic cancer_Homo sapiens_hsa052121.04402895
32Toxoplasmosis_Homo sapiens_hsa051451.02039822
33VEGF signaling pathway_Homo sapiens_hsa043700.98096173
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98043229
35Hepatitis B_Homo sapiens_hsa051610.95873559
36Shigellosis_Homo sapiens_hsa051310.92935128
37Influenza A_Homo sapiens_hsa051640.91162857
38Staphylococcus aureus infection_Homo sapiens_hsa051500.89191361
39HTLV-I infection_Homo sapiens_hsa051660.89053446
40Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83070617
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79876169
42Apoptosis_Homo sapiens_hsa042100.79592666
43Colorectal cancer_Homo sapiens_hsa052100.76708644
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75896679
45TNF signaling pathway_Homo sapiens_hsa046680.75343850
46Other glycan degradation_Homo sapiens_hsa005110.66455404
47Proteasome_Homo sapiens_hsa030500.63219765
48Salmonella infection_Homo sapiens_hsa051320.62304067
49Phagosome_Homo sapiens_hsa041450.60905963
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60622086
51Epstein-Barr virus infection_Homo sapiens_hsa051690.59222309
52Asthma_Homo sapiens_hsa053100.59040439
53Acute myeloid leukemia_Homo sapiens_hsa052210.58646953
54Tuberculosis_Homo sapiens_hsa051520.56193005
55Mismatch repair_Homo sapiens_hsa034300.56084257
56Platelet activation_Homo sapiens_hsa046110.55454085
57Hepatitis C_Homo sapiens_hsa051600.53509631
58Rheumatoid arthritis_Homo sapiens_hsa053230.53316390
59DNA replication_Homo sapiens_hsa030300.53064361
60p53 signaling pathway_Homo sapiens_hsa041150.50776052
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50730731
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50274487
63Legionellosis_Homo sapiens_hsa051340.50069656
64Non-homologous end-joining_Homo sapiens_hsa034500.47900995
65Base excision repair_Homo sapiens_hsa034100.46449070
66Ribosome_Homo sapiens_hsa030100.43210122
67Endocytosis_Homo sapiens_hsa041440.41184194
68RNA degradation_Homo sapiens_hsa030180.40603722
69Viral carcinogenesis_Homo sapiens_hsa052030.40546633
70Adherens junction_Homo sapiens_hsa045200.39956835
71Pentose phosphate pathway_Homo sapiens_hsa000300.39938319
72Pertussis_Homo sapiens_hsa051330.38644726
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38425025
74Alcoholism_Homo sapiens_hsa050340.35418877
75Homologous recombination_Homo sapiens_hsa034400.33118464
76Caffeine metabolism_Homo sapiens_hsa002320.31095749
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29066909
78Prolactin signaling pathway_Homo sapiens_hsa049170.28436392
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28166733
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27234062
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26224105
82African trypanosomiasis_Homo sapiens_hsa051430.26003770
83Lysosome_Homo sapiens_hsa041420.25500550
84Chronic myeloid leukemia_Homo sapiens_hsa052200.25453371
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.25386576
86Spliceosome_Homo sapiens_hsa030400.24562908
87Regulation of autophagy_Homo sapiens_hsa041400.24157648
88Nucleotide excision repair_Homo sapiens_hsa034200.23932079
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.18184223
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18167662
91Rap1 signaling pathway_Homo sapiens_hsa040150.16094277
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14012584
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.12890367
94Basal transcription factors_Homo sapiens_hsa030220.12231615
95RNA polymerase_Homo sapiens_hsa030200.11907918
96Small cell lung cancer_Homo sapiens_hsa052220.11561658
97MAPK signaling pathway_Homo sapiens_hsa040100.11097976
98ABC transporters_Homo sapiens_hsa020100.11026824
99Linoleic acid metabolism_Homo sapiens_hsa005910.10300128
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10199064
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09969034
102Notch signaling pathway_Homo sapiens_hsa043300.09709013
103Non-small cell lung cancer_Homo sapiens_hsa052230.09701472
104FoxO signaling pathway_Homo sapiens_hsa040680.09624791
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.07815002
106Choline metabolism in cancer_Homo sapiens_hsa052310.07342722
107Cell cycle_Homo sapiens_hsa041100.06649880
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04641358
109Focal adhesion_Homo sapiens_hsa045100.02472429
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.02146257
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02004833
112Ras signaling pathway_Homo sapiens_hsa040140.01042056
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.00792217
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.00388887
115Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0504025
116N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0463270
117Prion diseases_Homo sapiens_hsa05020-0.0461895
118Type II diabetes mellitus_Homo sapiens_hsa04930-0.0450294
119Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0351533
120Renal cell carcinoma_Homo sapiens_hsa05211-0.0169196
121Insulin resistance_Homo sapiens_hsa04931-0.0035190
122Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0034590

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