CXCR2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)7.64030605
2thrombin receptor signaling pathway (GO:0070493)6.91470797
3protein neddylation (GO:0045116)5.84240807
4regulation of platelet aggregation (GO:0090330)5.72105678
5leukocyte migration involved in inflammatory response (GO:0002523)5.54469229
6positive regulation of mast cell activation (GO:0033005)5.53208578
7regulation of platelet activation (GO:0010543)5.27498767
8blood coagulation, intrinsic pathway (GO:0007597)4.85127998
9platelet aggregation (GO:0070527)4.83663886
10adenosine receptor signaling pathway (GO:0001973)4.82942676
11neutrophil activation (GO:0042119)4.79471163
12negative regulation of homotypic cell-cell adhesion (GO:0034111)4.49946139
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.45937186
14angiogenesis involved in wound healing (GO:0060055)4.37165681
15lipoxygenase pathway (GO:0019372)4.34511911
16granulocyte activation (GO:0036230)4.27367860
17negative regulation of norepinephrine secretion (GO:0010700)4.16011888
18megakaryocyte development (GO:0035855)4.12026463
19regulation of integrin-mediated signaling pathway (GO:2001044)4.07950755
20negative regulation of platelet activation (GO:0010544)4.04002637
21positive regulation of endothelial cell differentiation (GO:0045603)4.02327940
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.91059694
23negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.88758493
24purinergic nucleotide receptor signaling pathway (GO:0035590)3.78165293
25positive regulation of macrophage differentiation (GO:0045651)3.74953825
26regulation of mast cell activation (GO:0033003)3.70931898
27positive regulation of mast cell activation involved in immune response (GO:0033008)3.69274734
28positive regulation of mast cell degranulation (GO:0043306)3.69274734
29regulation of integrin activation (GO:0033623)3.66408366
30regulation of lipoprotein metabolic process (GO:0050746)3.64370274
31negative regulation of thymocyte apoptotic process (GO:0070244)3.63377868
32positive regulation of cAMP-mediated signaling (GO:0043950)3.56823474
33platelet degranulation (GO:0002576)3.56759522
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.56747804
35homotypic cell-cell adhesion (GO:0034109)3.52194477
36regulation of homotypic cell-cell adhesion (GO:0034110)3.48916487
37regulation of mast cell degranulation (GO:0043304)3.48880435
38negative regulation of T-helper cell differentiation (GO:0045623)3.45834965
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.45834965
40platelet formation (GO:0030220)3.45661186
41cellular extravasation (GO:0045123)3.45284482
42G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.43408654
43platelet activation (GO:0030168)3.40295096
44regulation of MHC class II biosynthetic process (GO:0045346)3.32455449
45regulation of mast cell activation involved in immune response (GO:0033006)3.31987461
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30329970
47regulation of regulatory T cell differentiation (GO:0045589)3.29974998
48positive regulation of blood coagulation (GO:0030194)3.29860134
49positive regulation of hemostasis (GO:1900048)3.29860134
50myeloid cell activation involved in immune response (GO:0002275)3.27370884
51purinergic receptor signaling pathway (GO:0035587)3.26755912
52low-density lipoprotein particle remodeling (GO:0034374)3.24430317
53negative regulation of heart rate (GO:0010459)3.22063775
54positive regulation of receptor recycling (GO:0001921)3.21699056
55dendritic cell chemotaxis (GO:0002407)3.21023215
56leukocyte degranulation (GO:0043299)3.18397096
57positive regulation of B cell mediated immunity (GO:0002714)3.16461423
58positive regulation of immunoglobulin mediated immune response (GO:0002891)3.16461423
59positive regulation of gamma-delta T cell activation (GO:0046645)3.14316667
60phagocytosis, engulfment (GO:0006911)3.14230415
61microglial cell activation (GO:0001774)3.13544173
62positive regulation of Rho protein signal transduction (GO:0035025)3.11296011
63regulation of T-helper 2 cell differentiation (GO:0045628)3.09111600
64regulation of Golgi to plasma membrane protein transport (GO:0042996)3.08401527
65regulation of macrophage derived foam cell differentiation (GO:0010743)3.02546292
66positive regulation of coagulation (GO:0050820)3.01403882
67regulation of memory T cell differentiation (GO:0043380)2.98432873
68negative regulation of interleukin-17 production (GO:0032700)2.95969928
69B cell mediated immunity (GO:0019724)2.94186166
70polyamine biosynthetic process (GO:0006596)2.92328952
71positive regulation of systemic arterial blood pressure (GO:0003084)2.89825591
72long-chain fatty acid biosynthetic process (GO:0042759)2.89141631
73positive regulation of granulocyte differentiation (GO:0030854)2.87532492
74fusion of sperm to egg plasma membrane (GO:0007342)2.85991674
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85058767
76negative regulation of cell killing (GO:0031342)2.85058767
77positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.84293972
78negative regulation of T cell apoptotic process (GO:0070233)2.83110142
79regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82605722
80termination of signal transduction (GO:0023021)2.81378930
81autophagic vacuole fusion (GO:0000046)2.81066928
82negative regulation of protein localization to cell surface (GO:2000009)2.79306738
83dendritic cell migration (GO:0036336)2.79071310
84positive regulation of cellular amide metabolic process (GO:0034250)2.78924578
85positive regulation of type 2 immune response (GO:0002830)2.78724359
86termination of G-protein coupled receptor signaling pathway (GO:0038032)2.78453668
87Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77744168
88negative regulation of heart contraction (GO:0045822)2.74493164
89regulation of T-helper 1 cell differentiation (GO:0045625)2.74360806
90immunoglobulin mediated immune response (GO:0016064)2.72682788
91negative regulation of appetite (GO:0032099)2.72325831
92negative regulation of response to food (GO:0032096)2.72325831
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.71617843
94regulation of hemostasis (GO:1900046)2.71208234
95regulation of blood coagulation (GO:0030193)2.71208234
96peptide catabolic process (GO:0043171)2.69270324
97regulation of leukocyte degranulation (GO:0043300)2.68962943
98regulation of norepinephrine secretion (GO:0014061)2.68610121
99negative regulation of neural precursor cell proliferation (GO:2000178)2.68423702
100negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.66630413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.17052625
2SCL_19346495_ChIP-Seq_HPC-7_Human4.06069580
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.71099649
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.59363725
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53368654
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.51807873
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.02456955
8GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.81961039
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77095564
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74529616
11GATA1_19941826_ChIP-Seq_K562_Human2.74062409
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73133964
13SPI1_23127762_ChIP-Seq_K562_Human2.69486608
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.66364319
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64388503
16LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.57985653
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.53766896
18GATA1_19941827_ChIP-Seq_MEL_Mouse2.50303551
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40241387
20GATA2_19941826_ChIP-Seq_K562_Human2.32360510
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31974067
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31157769
23GATA1_22025678_ChIP-Seq_K562_Human2.16315399
24TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.12301037
25GATA2_21666600_ChIP-Seq_HMVEC_Human2.08577130
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.01169802
27GATA1_22383799_ChIP-Seq_G1ME_Mouse1.97005071
28GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.96142486
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92920101
30RUNX_20019798_ChIP-Seq_JUKART_Human1.90730224
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89755796
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82379832
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72381987
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.66497383
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63875721
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63305396
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61685255
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.58998114
39GATA1_19941827_ChIP-Seq_MEL86_Mouse1.54272043
40SPI1_23547873_ChIP-Seq_NB4_Human1.53338143
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51923003
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48487084
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45589594
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40227822
45GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38705845
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37546079
47HTT_18923047_ChIP-ChIP_STHdh_Human1.36483795
48MYB_26560356_Chip-Seq_TH2_Human1.36409878
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27666326
50EZH2_22144423_ChIP-Seq_EOC_Human1.22743563
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.21632511
52GATA3_27048872_Chip-Seq_THYMUS_Human1.20905539
53VDR_24763502_ChIP-Seq_THP-1_Human1.19709217
54UTX_26944678_Chip-Seq_JUKART_Human1.15840783
55VDR_24787735_ChIP-Seq_THP-1_Human1.13305683
56KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12597060
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11836196
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11461848
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07952327
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07796169
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.05432684
62PU_27001747_Chip-Seq_BMDM_Mouse1.04858122
63GATA3_26560356_Chip-Seq_TH2_Human1.04089025
64GBX2_23144817_ChIP-Seq_PC3_Human1.03372474
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01746479
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98598762
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97847672
68NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97400553
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97400553
70SALL4_22934838_ChIP-ChIP_CD34+_Human0.96950699
71NCOR1_26117541_ChIP-Seq_K562_Human0.96948838
72SPI1_20517297_ChIP-Seq_HL60_Human0.96617745
73MYB_26560356_Chip-Seq_TH1_Human0.96132702
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93885430
75MAF_26560356_Chip-Seq_TH1_Human0.92503870
76ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92085537
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89707809
78ESR1_20079471_ChIP-ChIP_T-47D_Human0.89093114
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86479907
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85876403
81TAF15_26573619_Chip-Seq_HEK293_Human0.82527938
82TCF7_22412390_ChIP-Seq_EML_Mouse0.81684439
83SMRT_27268052_Chip-Seq_Bcells_Human0.80212608
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79734413
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79093656
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.78647566
87STAT1_20625510_ChIP-Seq_HELA_Human0.78605360
88TCF4_18268006_ChIP-ChIP_LS174T_Human0.76433645
89LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75308994
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74477167
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.74464786
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72993296
93GF1_26923725_Chip-Seq_HPCs_Mouse0.72530153
94SOX2_20726797_ChIP-Seq_SW620_Human0.71019508
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70645605
96LXR_22158963_ChIP-Seq_LIVER_Mouse0.69500806
97OCT1_27270436_Chip-Seq_PROSTATE_Human0.69331688
98CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68847587
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65577519
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.65397174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.39780364
2MP0008004_abnormal_stomach_pH5.00308489
3MP0003724_increased_susceptibility_to4.48438801
4MP0001835_abnormal_antigen_presentation3.27387291
5MP0000465_gastrointestinal_hemorrhage3.26484646
6MP0004510_myositis3.21834235
7MP0003303_peritoneal_inflammation2.91690595
8MP0005671_abnormal_response_to2.80990816
9MP0000343_altered_response_to2.34288664
10MP0003436_decreased_susceptibility_to2.32209235
11MP0002148_abnormal_hypersensitivity_rea2.28665554
12MP0005000_abnormal_immune_tolerance2.17353112
13MP0005083_abnormal_biliary_tract2.06788468
14MP0004084_abnormal_cardiac_muscle2.02730063
15MP0003566_abnormal_cell_adhesion1.96690770
16MP0003828_pulmonary_edema1.91600771
17MP0010155_abnormal_intestine_physiology1.87983208
18MP0001800_abnormal_humoral_immune1.80522842
19MP0002419_abnormal_innate_immunity1.80326187
20MP0005058_abnormal_lysosome_morphology1.80303777
21MP0002723_abnormal_immune_serum1.77634720
22MP0005387_immune_system_phenotype1.74145698
23MP0001790_abnormal_immune_system1.74145698
24MP0002452_abnormal_antigen_presenting1.72914769
25MP0002398_abnormal_bone_marrow1.69045930
26MP0005025_abnormal_response_to1.68847191
27MP0004947_skin_inflammation1.66330570
28MP0001533_abnormal_skeleton_physiology1.61775958
29MP0000230_abnormal_systemic_arterial1.59682835
30MP0001851_eye_inflammation1.58821091
31MP0002420_abnormal_adaptive_immunity1.54923473
32MP0001819_abnormal_immune_cell1.54114522
33MP0003300_gastrointestinal_ulcer1.50491356
34MP0003638_abnormal_response/metabolism_1.42751049
35MP0000858_altered_metastatic_potential1.39955261
36MP0000685_abnormal_immune_system1.38974339
37MP0005167_abnormal_blood-brain_barrier1.37412895
38MP0004130_abnormal_muscle_cell1.35647280
39MP0004036_abnormal_muscle_relaxation1.35463633
40MP0009764_decreased_sensitivity_to1.35411000
41MP0008775_abnormal_heart_ventricle1.34828470
42MP0000249_abnormal_blood_vessel1.34684858
43MP0009785_altered_susceptibility_to1.34610443
44MP0001845_abnormal_inflammatory_respons1.32953541
45MP0005084_abnormal_gallbladder_morpholo1.32383067
46MP0005397_hematopoietic_system_phenotyp1.32275689
47MP0001545_abnormal_hematopoietic_system1.32275689
48MP0002132_abnormal_respiratory_system1.31345222
49MP0001663_abnormal_digestive_system1.30334551
50MP0002736_abnormal_nociception_after1.30070043
51MP0000689_abnormal_spleen_morphology1.29623338
52MP0009763_increased_sensitivity_to1.28974853
53MP0000716_abnormal_immune_system1.26649588
54MP0002429_abnormal_blood_cell1.24993011
55MP0003866_abnormal_defecation1.22900474
56MP0000015_abnormal_ear_pigmentation1.19623291
57MP0003879_abnormal_hair_cell1.16677349
58MP0002722_abnormal_immune_system1.16363431
59MP0002998_abnormal_bone_remodeling1.16208277
60MP0009333_abnormal_splenocyte_physiolog1.15716590
61MP0010329_abnormal_lipoprotein_level1.08887191
62MP0008872_abnormal_physiological_respon1.06332961
63MP0006082_CNS_inflammation1.05153548
64MP0003172_abnormal_lysosome_physiology1.02570475
65MP0003075_altered_response_to1.02270356
66MP0003656_abnormal_erythrocyte_physiolo1.01917621
67MP0008874_decreased_physiological_sensi1.01709865
68MP0003183_abnormal_peptide_metabolism1.00824929
69MP0002405_respiratory_system_inflammati1.00772504
70MP0004883_abnormal_blood_vessel1.00066445
71MP0005410_abnormal_fertilization0.98878231
72MP0003448_altered_tumor_morphology0.95360393
73MP0009765_abnormal_xenobiotic_induced0.93843224
74MP0006054_spinal_hemorrhage0.88884178
75MP0005174_abnormal_tail_pigmentation0.87439103
76MP0005409_darkened_coat_color0.87308025
77MP0009642_abnormal_blood_homeostasis0.84994173
78MP0003763_abnormal_thymus_physiology0.83975925
79MP0001879_abnormal_lymphatic_vessel0.80878603
80MP0000703_abnormal_thymus_morphology0.80248490
81MP0002733_abnormal_thermal_nociception0.80094587
82MP0005381_digestive/alimentary_phenotyp0.77799052
83MP0004484_altered_response_of0.77764064
84MP0003091_abnormal_cell_migration0.76313929
85MP0005023_abnormal_wound_healing0.75945821
86MP0008260_abnormal_autophagy0.75126208
87MP0001765_abnormal_ion_homeostasis0.74498025
88MP0005165_increased_susceptibility_to0.73031405
89MP0005166_decreased_susceptibility_to0.72291545
90MP0001968_abnormal_touch/_nociception0.70655542
91MP0008469_abnormal_protein_level0.69720667
92MP0003453_abnormal_keratinocyte_physiol0.69622117
93MP0005365_abnormal_bile_salt0.69021664
94MP0000490_abnormal_crypts_of0.67440149
95MP0001664_abnormal_digestion0.65370895
96MP0002118_abnormal_lipid_homeostasis0.63886122
97MP0005310_abnormal_salivary_gland0.63721005
98MP0005666_abnormal_adipose_tissue0.61810669
99MP0004381_abnormal_hair_follicle0.61750632
100MP0005646_abnormal_pituitary_gland0.60833444

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.89985783
2Menorrhagia (HP:0000132)9.79490906
3Petechiae (HP:0000967)9.51017403
4Abnormal platelet volume (HP:0011876)9.50025322
5Purpura (HP:0000979)8.78376721
6Epistaxis (HP:0000421)7.58133636
7Gingival bleeding (HP:0000225)7.11807070
8Impaired platelet aggregation (HP:0003540)5.66331698
9Abnormal platelet function (HP:0011869)5.66331698
10Spontaneous hematomas (HP:0007420)5.12088977
11Hyperlipoproteinemia (HP:0010980)4.84473641
12Poikilocytosis (HP:0004447)3.83460810
13Abnormality of macrophages (HP:0004311)3.70601553
14Acanthocytosis (HP:0001927)3.66387161
15Abnormality of the common coagulation pathway (HP:0010990)3.51866613
16Bruising susceptibility (HP:0000978)3.47128655
17Dyschromatopsia (HP:0007641)3.34423432
18Conjunctival telangiectasia (HP:0000524)3.21723326
19Abnormality of the vasculature of the conjunctiva (HP:0008054)2.92095458
20Eczematoid dermatitis (HP:0000976)2.90184150
21Abnormal pupillary function (HP:0007686)2.86190203
22Stomatitis (HP:0010280)2.84936242
23Increased density of long bones (HP:0006392)2.83472516
24Recurrent abscess formation (HP:0002722)2.79772047
25Recurrent bacterial skin infections (HP:0005406)2.78614817
26Abnormality of the heme biosynthetic pathway (HP:0010472)2.71558336
27Joint hemorrhage (HP:0005261)2.68006091
28Hepatosplenomegaly (HP:0001433)2.67722601
29Paralysis (HP:0003470)2.61175475
30Obstructive lung disease (HP:0006536)2.58205419
31Chronic obstructive pulmonary disease (HP:0006510)2.58205419
32Encephalitis (HP:0002383)2.44908121
33Abnormality of lateral ventricle (HP:0030047)2.44543012
34Joint swelling (HP:0001386)2.44212229
35Increased IgM level (HP:0003496)2.43606771
36Arterial thrombosis (HP:0004420)2.43464704
37Chest pain (HP:0100749)2.26957272
38Abnormality of iron homeostasis (HP:0011031)2.21661224
39Tinnitus (HP:0000360)2.17479464
40Abnormal auditory evoked potentials (HP:0006958)2.13177359
41Xanthomatosis (HP:0000991)2.11480747
42Upper limb muscle weakness (HP:0003484)2.02568179
43Prolonged bleeding time (HP:0003010)10.9350467
44Episodic fever (HP:0001954)1.98927941
45Spontaneous abortion (HP:0005268)1.98348398
46Thrombocytosis (HP:0001894)1.97107758
47Vertigo (HP:0002321)1.95098876
48Myocardial infarction (HP:0001658)1.94370672
49Elevated erythrocyte sedimentation rate (HP:0003565)1.92026881
50Ventricular fibrillation (HP:0001663)1.91979803
51Abnormality of transition element cation homeostasis (HP:0011030)1.88317823
52Dysostosis multiplex (HP:0000943)1.88293125
53Inflammation of the large intestine (HP:0002037)1.87833739
54Increased serum ferritin (HP:0003281)1.87506438
55Polycythemia (HP:0001901)1.87271069
56Autoimmune hemolytic anemia (HP:0001890)1.83074092
57Decreased central vision (HP:0007663)1.83055083
58Abnormality of the prostate (HP:0008775)1.82123731
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81423516
60Systemic lupus erythematosus (HP:0002725)1.81372398
61Basal ganglia calcification (HP:0002135)1.80668453
62Amaurosis fugax (HP:0100576)1.79525344
63Leukocytosis (HP:0001974)1.79000903
64Vacuolated lymphocytes (HP:0001922)1.77791635
65Vasculitis (HP:0002633)1.76709677
66Meningitis (HP:0001287)1.75402659
67Recurrent fungal infections (HP:0002841)1.74555031
68Thrombophlebitis (HP:0004418)1.74149209
69Optic neuritis (HP:0100653)1.72939418
70Retrobulbar optic neuritis (HP:0100654)1.72939418
71Nausea (HP:0002018)1.72663840
72Distal lower limb amyotrophy (HP:0008944)1.72344171
73Gastrointestinal inflammation (HP:0004386)1.71039972
74Myositis (HP:0100614)1.67645532
75Papillary thyroid carcinoma (HP:0002895)1.67619531
76Recurrent skin infections (HP:0001581)1.67462947
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.66444871
78Pulmonary embolism (HP:0002204)1.65940953
79Recurrent gram-negative bacterial infections (HP:0005420)1.65608480
80Orchitis (HP:0100796)1.62047093
81Muscle fibrillation (HP:0010546)1.57778336
82Increased cerebral lipofuscin (HP:0011813)1.57523563
83Mucosal telangiectasiae (HP:0100579)1.56706000
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.56265498
85Male infertility (HP:0003251)1.54815643
86Cerebral ischemia (HP:0002637)1.53744625
87Abnormality of binocular vision (HP:0011514)1.53006179
88Diplopia (HP:0000651)1.53006179
89Gastrointestinal infarctions (HP:0005244)1.51894523
90Increased neuronal autofluorescent lipopigment (HP:0002074)1.51832495
91T lymphocytopenia (HP:0005403)1.51605774
92Generalized aminoaciduria (HP:0002909)1.50408695
93Leiomyosarcoma (HP:0100243)1.48560821
94Uterine leiomyosarcoma (HP:0002891)1.48560821
95Chronic otitis media (HP:0000389)1.48490741
96Arthralgia (HP:0002829)1.48150865
97Transitional cell carcinoma of the bladder (HP:0006740)1.46833267
98Recurrent cutaneous fungal infections (HP:0011370)1.46305391
99Chronic mucocutaneous candidiasis (HP:0002728)1.46305391
100Abnormality of T cell number (HP:0011839)1.45626632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.20119554
2MST43.85275038
3BMX3.51681959
4TEC3.10566911
5BTK2.89560109
6MYLK2.75238597
7BLK2.62962792
8SYK2.57923308
9CSF1R2.48083467
10EIF2AK12.47446721
11PTK2B2.34829074
12PIK3CG2.31091245
13ZAP702.30869565
14TAOK32.23505158
15BMPR22.10026205
16FGR1.99525466
17GRK61.92995333
18HCK1.77018201
19FES1.70006806
20GRK51.65140999
21CSK1.54555279
22MAP2K31.49757192
23STK31.41895576
24LYN1.38296676
25TNK21.37664574
26MAP4K11.36742405
27TXK1.32892943
28ILK1.21380184
29ADRBK21.19839213
30ITK1.19322048
31JAK31.12553575
32IKBKB1.11610136
33PDK11.09274678
34STK241.09060063
35PDPK11.04531797
36MATK1.04273228
37ACVR1B1.03956532
38IRAK10.97613565
39JAK10.96872823
40SIK30.96602012
41PAK10.92386955
42YES10.91525688
43TYK20.88423904
44TNIK0.86774164
45MAP3K50.86296304
46JAK20.86208684
47IRAK40.86100662
48LCK0.81554274
49PIM20.80083963
50EPHB10.79405726
51EPHA30.78649171
52MAP3K30.75405214
53TAOK10.74983491
54DAPK30.74623663
55ARAF0.72707533
56RET0.71650640
57MAPKAPK30.71101858
58LMTK20.69103500
59MARK30.67526483
60PNCK0.66650057
61ERBB20.63204023
62FYN0.63024734
63ADRBK10.62843942
64PRKD10.61233055
65TAOK20.59482103
66MAPK120.59070822
67CAMKK20.58684442
68STK40.58473069
69DAPK20.57132278
70PDGFRB0.55434616
71IRAK20.52339548
72TESK20.51503939
73SGK20.50348875
74PLK20.49464071
75PRKACG0.48473668
76MAP2K10.47952239
77IKBKE0.47302213
78SGK30.46543742
79FER0.46261588
80PRKCQ0.46219163
81MAP3K10.44721335
82TRIM280.44405332
83MAP3K140.41661373
84NLK0.41134143
85PRKCD0.40478570
86HIPK20.38220230
87RAF10.34989836
88NEK90.34978251
89MAP3K110.34339218
90CDC42BPA0.34196305
91IRAK30.34135697
92PRKG10.33311071
93PIM10.30800523
94KSR20.30484583
95SRC0.28401878
96PKN10.27901601
97PRKCB0.26262721
98IGF1R0.25504300
99KIT0.24434029
100CAMK1G0.24067922

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.62182608
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.93141688
3Hematopoietic cell lineage_Homo sapiens_hsa046402.79255414
4Staphylococcus aureus infection_Homo sapiens_hsa051502.28713034
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.23441851
6Chemokine signaling pathway_Homo sapiens_hsa040622.15998923
7B cell receptor signaling pathway_Homo sapiens_hsa046621.81029889
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78496687
9Osteoclast differentiation_Homo sapiens_hsa043801.75646240
10Arachidonic acid metabolism_Homo sapiens_hsa005901.69341956
11Graft-versus-host disease_Homo sapiens_hsa053321.62189557
12Leishmaniasis_Homo sapiens_hsa051401.61311611
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60143691
14Allograft rejection_Homo sapiens_hsa053301.55310226
15Asthma_Homo sapiens_hsa053101.48224603
16Phagosome_Homo sapiens_hsa041451.47452709
17Autoimmune thyroid disease_Homo sapiens_hsa053201.47386506
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45121936
19ECM-receptor interaction_Homo sapiens_hsa045121.38527767
20Gap junction_Homo sapiens_hsa045401.36634494
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36579660
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34859539
23T cell receptor signaling pathway_Homo sapiens_hsa046601.30836758
24Malaria_Homo sapiens_hsa051441.28971464
25Tuberculosis_Homo sapiens_hsa051521.24995083
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.24882028
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.22906674
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22802091
29Systemic lupus erythematosus_Homo sapiens_hsa053221.21689638
30Nitrogen metabolism_Homo sapiens_hsa009101.19904602
31Shigellosis_Homo sapiens_hsa051311.19830042
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19711097
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18801881
34Serotonergic synapse_Homo sapiens_hsa047261.16527187
35Endocytosis_Homo sapiens_hsa041441.16163427
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.11148280
37Primary immunodeficiency_Homo sapiens_hsa053401.09029890
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08500234
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.05318004
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01927319
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01569506
42Collecting duct acid secretion_Homo sapiens_hsa049660.98944809
43Pancreatic secretion_Homo sapiens_hsa049720.95815398
44Type I diabetes mellitus_Homo sapiens_hsa049400.95124723
45Viral myocarditis_Homo sapiens_hsa054160.94846454
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89866111
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88083103
48Toxoplasmosis_Homo sapiens_hsa051450.84486832
49Non-small cell lung cancer_Homo sapiens_hsa052230.83934520
50Long-term depression_Homo sapiens_hsa047300.82726129
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82235548
52Linoleic acid metabolism_Homo sapiens_hsa005910.81388778
53Rheumatoid arthritis_Homo sapiens_hsa053230.81108002
54Pancreatic cancer_Homo sapiens_hsa052120.80813982
55Measles_Homo sapiens_hsa051620.79772894
56Glycerolipid metabolism_Homo sapiens_hsa005610.79549991
57Legionellosis_Homo sapiens_hsa051340.79440107
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.78845049
59Choline metabolism in cancer_Homo sapiens_hsa052310.78349418
60Alcoholism_Homo sapiens_hsa050340.77890798
61Rap1 signaling pathway_Homo sapiens_hsa040150.77515688
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73029125
63Complement and coagulation cascades_Homo sapiens_hsa046100.69943690
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.69116205
65Influenza A_Homo sapiens_hsa051640.67605253
66Salmonella infection_Homo sapiens_hsa051320.66331730
67Antigen processing and presentation_Homo sapiens_hsa046120.65848098
68Amoebiasis_Homo sapiens_hsa051460.64586552
69Focal adhesion_Homo sapiens_hsa045100.63105184
70Acute myeloid leukemia_Homo sapiens_hsa052210.62694944
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61761117
72Endometrial cancer_Homo sapiens_hsa052130.60040098
73VEGF signaling pathway_Homo sapiens_hsa043700.57683245
74Pertussis_Homo sapiens_hsa051330.56666102
75Olfactory transduction_Homo sapiens_hsa047400.56176022
76Apoptosis_Homo sapiens_hsa042100.55096398
77Renin-angiotensin system_Homo sapiens_hsa046140.54531804
78Renal cell carcinoma_Homo sapiens_hsa052110.54252461
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53979912
80Lysosome_Homo sapiens_hsa041420.52973694
81Viral carcinogenesis_Homo sapiens_hsa052030.52758852
82Morphine addiction_Homo sapiens_hsa050320.50713719
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.48947815
84Circadian entrainment_Homo sapiens_hsa047130.47306781
85Ras signaling pathway_Homo sapiens_hsa040140.46894950
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46596895
87Renin secretion_Homo sapiens_hsa049240.44377609
88Sulfur metabolism_Homo sapiens_hsa009200.42870584
89Herpes simplex infection_Homo sapiens_hsa051680.41842363
90TNF signaling pathway_Homo sapiens_hsa046680.41837838
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39833421
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.39690539
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39279336
94Fatty acid elongation_Homo sapiens_hsa000620.38642107
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38364844
96Glioma_Homo sapiens_hsa052140.38177649
97Cholinergic synapse_Homo sapiens_hsa047250.37650813
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36646500
99Gastric acid secretion_Homo sapiens_hsa049710.36307059
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.36253318

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