CXCL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)6.15436766
2positive regulation of chemokine biosynthetic process (GO:0045080)6.14683933
3response to peptidoglycan (GO:0032494)6.11981670
4positive regulation of heat generation (GO:0031652)6.11893301
5regulation of fever generation (GO:0031620)5.99956833
6regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.48140511
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.39727821
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.39727821
9modulation by symbiont of host immune response (GO:0052553)5.39727821
10positive regulation by symbiont of host defense response (GO:0052509)5.39727821
11modulation by symbiont of host defense response (GO:0052031)5.39727821
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.39727821
13positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.37329596
14positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.09670332
15regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.09670332
16regulation of activation of Janus kinase activity (GO:0010533)5.05251624
17regulation of chemokine biosynthetic process (GO:0045073)5.04616856
18lipopolysaccharide-mediated signaling pathway (GO:0031663)5.00667629
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.95488751
20regulation of T-helper 1 cell differentiation (GO:0045625)4.71471802
21regulation of heat generation (GO:0031650)4.69108718
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.61471697
23cellular response to exogenous dsRNA (GO:0071360)4.48032556
24positive regulation of NF-kappaB import into nucleus (GO:0042346)4.44589653
25negative regulation of cytokine production involved in immune response (GO:0002719)4.40697110
26regulation of cytokine secretion involved in immune response (GO:0002739)4.33399753
27natural killer cell activation involved in immune response (GO:0002323)4.32441581
28neutrophil activation involved in immune response (GO:0002283)4.31722593
29negative regulation of amino acid transport (GO:0051956)4.31281460
30eosinophil chemotaxis (GO:0048245)4.23080336
31regulation of heterotypic cell-cell adhesion (GO:0034114)4.18425958
32cellular response to interferon-beta (GO:0035458)4.16283165
33regulation of vitamin D biosynthetic process (GO:0060556)4.12959894
34regulation of chronic inflammatory response (GO:0002676)4.00190806
35regulation of podosome assembly (GO:0071801)3.99171112
36regulation of mononuclear cell migration (GO:0071675)3.98288220
37positive regulation of T-helper 1 type immune response (GO:0002827)3.98229037
38positive regulation of T-helper cell differentiation (GO:0045624)3.95136147
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.92480668
40superoxide anion generation (GO:0042554)3.91865660
41regulation of memory T cell differentiation (GO:0043380)3.90671406
42oligosaccharide catabolic process (GO:0009313)3.90071317
43response to muramyl dipeptide (GO:0032495)3.86725836
44positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.85952619
45eosinophil migration (GO:0072677)3.85625509
46regulation of membrane protein ectodomain proteolysis (GO:0051043)3.84971700
47activation of MAPKKK activity (GO:0000185)3.84488417
48negative regulation of nitric oxide biosynthetic process (GO:0045019)3.80256954
49positive regulation of interferon-alpha production (GO:0032727)3.78626753
50response to protozoan (GO:0001562)3.77890010
51regulation of immunoglobulin secretion (GO:0051023)3.77440335
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.77211143
53regulation of lymphocyte chemotaxis (GO:1901623)3.76471081
54macrophage activation involved in immune response (GO:0002281)3.75163634
55positive regulation of alpha-beta T cell proliferation (GO:0046641)3.73717843
56granulocyte activation (GO:0036230)3.72556204
57response to interferon-beta (GO:0035456)3.72090697
58hydrogen peroxide biosynthetic process (GO:0050665)3.72033059
59positive regulation of nitric oxide biosynthetic process (GO:0045429)3.71927406
60regulation of interferon-alpha production (GO:0032647)3.71113383
61regulation of vitamin metabolic process (GO:0030656)3.64788748
62positive regulation of interleukin-17 production (GO:0032740)3.64271945
63regulation of interleukin-17 production (GO:0032660)3.63583720
64negative regulation of viral genome replication (GO:0045071)3.58837663
65positive regulation of mast cell degranulation (GO:0043306)3.57717888
66positive regulation of mast cell activation involved in immune response (GO:0033008)3.57717888
67regulation of T-helper 2 cell differentiation (GO:0045628)3.55220429
68negative regulation of production of molecular mediator of immune response (GO:0002701)3.54896542
69negative regulation by host of viral transcription (GO:0043922)3.52865967
70detection of molecule of bacterial origin (GO:0032490)3.52782988
71response to host immune response (GO:0052572)3.51363658
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.51363658
73branching involved in labyrinthine layer morphogenesis (GO:0060670)3.48219328
74regulation of T-helper 1 type immune response (GO:0002825)3.47436354
75respiratory burst (GO:0045730)3.46225576
76positive regulation of lymphocyte migration (GO:2000403)3.45165509
77positive regulation of humoral immune response (GO:0002922)3.44548261
78regulation of interleukin-8 biosynthetic process (GO:0045414)3.43152903
79regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.41731024
80negative regulation of interleukin-17 production (GO:0032700)3.38937882
81negative regulation of T cell mediated immunity (GO:0002710)3.38472555
82regulation of interferon-beta biosynthetic process (GO:0045357)3.37814493
83positive regulation of interleukin-12 production (GO:0032735)3.36265771
84monocyte chemotaxis (GO:0002548)3.35607071
85positive regulation of interleukin-10 production (GO:0032733)3.34388947
86glycosphingolipid catabolic process (GO:0046479)3.33809982
87positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.33736842
88cellular response to lipopolysaccharide (GO:0071222)3.30606279
89leukocyte aggregation (GO:0070486)3.30361020
90positive regulation of interleukin-6 production (GO:0032755)3.29654892
91regulation of T-helper cell differentiation (GO:0045622)3.29645993
92negative regulation of type 2 immune response (GO:0002829)3.27777985
93lymphocyte chemotaxis (GO:0048247)3.27591937
94reactive oxygen species biosynthetic process (GO:1903409)3.27139209
95regulation of vascular endothelial growth factor production (GO:0010574)3.27104463
96cellular response to nicotine (GO:0071316)3.26246019
97T cell migration (GO:0072678)3.25392329
98defense response to protozoan (GO:0042832)3.24327429
99positive regulation of tumor necrosis factor production (GO:0032760)3.23749670
100positive regulation of chemokine production (GO:0032722)3.23169944
101positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.23003949
102negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.22695318
103negative regulation of interleukin-12 production (GO:0032695)3.22504055
104NIK/NF-kappaB signaling (GO:0038061)3.22105473
105positive regulation of interleukin-1 beta secretion (GO:0050718)3.21854404
106positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.21692305
107regulation of mast cell degranulation (GO:0043304)3.21159145
108glycolipid catabolic process (GO:0019377)3.20944005
109neutrophil chemotaxis (GO:0030593)3.19376248
110chronic inflammatory response (GO:0002544)3.18729400
111regulation of NF-kappaB import into nucleus (GO:0042345)3.17657880
112cellular response to molecule of bacterial origin (GO:0071219)3.15842475
113germinal center formation (GO:0002467)3.15524109
114regulation of T cell cytokine production (GO:0002724)3.14855027
115cellular extravasation (GO:0045123)3.14685317
116regulation of nitric oxide biosynthetic process (GO:0045428)3.14270861
117negative regulation of lipid storage (GO:0010888)3.13762272
118positive regulation of acute inflammatory response (GO:0002675)3.13296614
119regulation of MHC class I biosynthetic process (GO:0045343)3.13137545
120T-helper 1 type immune response (GO:0042088)3.12730364
121positive regulation of p38MAPK cascade (GO:1900745)3.10200777
122positive regulation of type 2 immune response (GO:0002830)3.05912509
123cellular response to thyroid hormone stimulus (GO:0097067)2.86670675
124virion attachment to host cell (GO:0019062)2.85208836
125adhesion of symbiont to host cell (GO:0044650)2.85208836
126regulation of interleukin-6 production (GO:0032675)2.83654715
127negative regulation of growth of symbiont in host (GO:0044130)2.78349570
128negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.78349570
129modulation of growth of symbiont involved in interaction with host (GO:0044144)2.78349570
130regulation of growth of symbiont in host (GO:0044126)2.78349570
131positive regulation of prostaglandin secretion (GO:0032308)2.77178951
132neutrophil migration (GO:1990266)2.77174652
133cellular response to arsenic-containing substance (GO:0071243)2.76548645
134negative regulation of cytokine secretion (GO:0050710)2.76313965
135ovulation (GO:0030728)2.75752438
136regulation of prostaglandin secretion (GO:0032306)2.74996185
137cellular response to biotic stimulus (GO:0071216)2.74361018
138immunoglobulin mediated immune response (GO:0016064)2.74144318
139negative regulation of myeloid cell apoptotic process (GO:0033033)2.70218023
140positive regulation vascular endothelial growth factor production (GO:0010575)2.69742357
141macrophage chemotaxis (GO:0048246)2.67901277
142positive regulation of transcription factor import into nucleus (GO:0042993)2.67750227
143acute-phase response (GO:0006953)2.66585026
144ceramide catabolic process (GO:0046514)2.65815494
145myeloid dendritic cell differentiation (GO:0043011)2.60597054
146regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.59477276
147granulocyte chemotaxis (GO:0071621)2.59304178
148regulation of lipid storage (GO:0010883)2.56107994
149regulation of type 2 immune response (GO:0002828)2.55800055
150response to manganese ion (GO:0010042)2.55731059
151regulation of inflammatory response to antigenic stimulus (GO:0002861)2.55019138
152membrane lipid catabolic process (GO:0046466)2.54274909
153type I interferon signaling pathway (GO:0060337)2.51072605
154cellular response to type I interferon (GO:0071357)2.51072605
155negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.51025887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.58414221
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.64135767
3* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.00744483
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.00402672
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.87903685
6* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.86961668
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.78891238
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.46415904
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.30245490
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83711567
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82141893
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70178210
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65816586
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44178594
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21422364
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10656599
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08082085
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02349789
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00825221
20BP1_19119308_ChIP-ChIP_Hs578T_Human10.7864772
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.99907034
22VDR_24787735_ChIP-Seq_THP-1_Human1.96370709
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91074711
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87813669
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85851886
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.77713223
27PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73138592
28SPI1_23547873_ChIP-Seq_NB4_Human1.62052104
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59276232
30VDR_24763502_ChIP-Seq_THP-1_Human1.58647123
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57514095
32PU_27001747_Chip-Seq_BMDM_Mouse1.55891811
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53634864
34CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53221491
35CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50266037
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47840133
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.42440031
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40069421
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.39223523
40SPI1_23127762_ChIP-Seq_K562_Human1.38661246
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.37822429
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36103835
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36103835
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36103835
45CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29763334
46RUNX_20019798_ChIP-Seq_JUKART_Human1.26840689
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23026079
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.22272285
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.21581754
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19705096
51MYB_26560356_Chip-Seq_TH2_Human1.19314386
52CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18805687
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18171878
54CLOCK_20551151_ChIP-Seq_293T_Human1.15310027
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14667314
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14053800
57SCL_19346495_ChIP-Seq_HPC-7_Human1.13057039
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11835954
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10756523
60GATA1_19941826_ChIP-Seq_K562_Human1.09669821
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08466071
62GATA1_22025678_ChIP-Seq_K562_Human1.06831507
63* GATA2_21666600_ChIP-Seq_HMVEC_Human1.06196203
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06046367
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05161246
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03688355
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03240437
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02514409
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02348355
70* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02287403
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01998127
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01998127
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99819024
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99290801
75SOX2_20726797_ChIP-Seq_SW620_Human0.97187794
76TRIM28_21343339_ChIP-Seq_HEK293_Human0.95972036
77GATA3_26560356_Chip-Seq_TH2_Human0.94756417
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93526764
79NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91783684
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91296237
81TCF7_22412390_ChIP-Seq_EML_Mouse0.91074059
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90486024
83* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90062787
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89787018
85* GATA3_27048872_Chip-Seq_THYMUS_Human0.88792627
86MAF_26560356_Chip-Seq_TH1_Human0.87134151
87STAT1_20625510_ChIP-Seq_HELA_Human0.85769678
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85018271
89* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84182408
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83533731
91UBF1/2_26484160_Chip-Seq_HMECs_Human0.83064943
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81959929
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81804560
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81508429
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.81396952
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80059335
97* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79905162
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.79555237
99EGR1_19032775_ChIP-ChIP_M12_Human0.77705956
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76197148
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76197148
102* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74791789
103IGF1R_20145208_ChIP-Seq_DFB_Human0.73630993
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.73471480
105MYB_26560356_Chip-Seq_TH1_Human0.73436581
106* CJUN_26792858_Chip-Seq_BT549_Human0.72690876
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.71269304
108UTX_26944678_Chip-Seq_JUKART_Human0.69571892
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68538529
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.66452389
111EGR1_23403033_ChIP-Seq_LIVER_Mouse0.66194956
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64846347
113P63_26484246_Chip-Seq_KERATINOCYTES_Human0.64198844
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.63678573
115* GATA2_19941826_ChIP-Seq_K562_Human0.62425147
116LXR_22158963_ChIP-Seq_LIVER_Mouse0.61820571
117TP53_16413492_ChIP-PET_HCT116_Human0.61354496
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.60914615
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.60863335
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.60659770
121VDR_21846776_ChIP-Seq_THP-1_Human0.59627257
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.58915607
123* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.58634763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation5.74155735
2MP0009785_altered_susceptibility_to4.81351672
3MP0003436_decreased_susceptibility_to4.31625339
4MP0003724_increased_susceptibility_to4.17077129
5MP0002148_abnormal_hypersensitivity_rea3.92719270
6MP0003303_peritoneal_inflammation3.87860920
7MP0005000_abnormal_immune_tolerance3.54855951
8MP0002419_abnormal_innate_immunity3.43258585
9MP0001835_abnormal_antigen_presentation3.28882175
10MP0002139_abnormal_hepatobiliary_system3.17897517
11MP0005025_abnormal_response_to3.15510924
12MP0009764_decreased_sensitivity_to2.71723844
13MP0004947_skin_inflammation2.45142892
14MP0002452_abnormal_antigen_presenting2.42994005
15MP0002723_abnormal_immune_serum2.42169466
16MP0001533_abnormal_skeleton_physiology2.35901684
17MP0009278_abnormal_bone_marrow2.31399332
18MP0002006_tumorigenesis2.26964747
19MP0001800_abnormal_humoral_immune2.26116635
20MP0004510_myositis2.18581185
21MP0005671_abnormal_response_to2.17864340
22MP0005464_abnormal_platelet_physiology2.10873004
23MP0005387_immune_system_phenotype2.03041077
24MP0001790_abnormal_immune_system2.03041077
25MP0003075_altered_response_to2.00921024
26MP0001819_abnormal_immune_cell1.95952436
27MP0002420_abnormal_adaptive_immunity1.94137534
28MP0003690_abnormal_glial_cell1.93887891
29MP0001845_abnormal_inflammatory_respons1.92627757
30MP0005058_abnormal_lysosome_morphology1.89770727
31MP0008469_abnormal_protein_level1.89686975
32MP0003806_abnormal_nucleotide_metabolis1.82560379
33MP0006054_spinal_hemorrhage1.81453009
34MP0003448_altered_tumor_morphology1.80189773
35MP0000343_altered_response_to1.78230030
36MP0008004_abnormal_stomach_pH1.76135607
37MP0000685_abnormal_immune_system1.72729110
38MP0001853_heart_inflammation1.68899883
39MP0002405_respiratory_system_inflammati1.67183329
40MP0003828_pulmonary_edema1.66732172
41MP0010155_abnormal_intestine_physiology1.63764334
42MP0009333_abnormal_splenocyte_physiolog1.57852381
43MP0005166_decreased_susceptibility_to1.54379225
44MP0005167_abnormal_blood-brain_barrier1.53712443
45MP0000858_altered_metastatic_potential1.51925952
46MP0005164_abnormal_response_to1.51059345
47MP0003453_abnormal_keratinocyte_physiol1.46223719
48MP0002998_abnormal_bone_remodeling1.34171434
49MP0002254_reproductive_system_inflammat1.27612719
50MP0000716_abnormal_immune_system1.24775156
51MP0002332_abnormal_exercise_endurance1.22574421
52MP0003172_abnormal_lysosome_physiology1.22152116
53MP0003195_calcinosis1.18874672
54MP0003950_abnormal_plasma_membrane1.17766859
55MP0005397_hematopoietic_system_phenotyp1.17394198
56MP0001545_abnormal_hematopoietic_system1.17394198
57MP0002933_joint_inflammation1.16820265
58MP0000465_gastrointestinal_hemorrhage1.15304533
59MP0010352_gastrointestinal_tract_polyps1.14743774
60MP0005390_skeleton_phenotype1.14528236
61MP0001501_abnormal_sleep_pattern1.13682091
62MP0005076_abnormal_cell_differentiation1.13166807
63MP0000604_amyloidosis1.12552974
64MP0002398_abnormal_bone_marrow1.10177528
65MP0009840_abnormal_foam_cell1.09262953
66MP0001542_abnormal_bone_strength1.06478814
67MP0009763_increased_sensitivity_to1.03347053
68MP0005310_abnormal_salivary_gland1.02471396
69MP0003191_abnormal_cellular_cholesterol1.00498360
70MP0003656_abnormal_erythrocyte_physiolo0.99070931
71MP0001851_eye_inflammation0.97811925
72MP0002429_abnormal_blood_cell0.96556224
73MP0002277_abnormal_respiratory_mucosa0.94413311
74MP0004883_abnormal_blood_vessel0.93422002
75MP0002138_abnormal_hepatobiliary_system0.93183457
76MP0000689_abnormal_spleen_morphology0.92577294
77MP0004808_abnormal_hematopoietic_stem0.92482186
78MP0009765_abnormal_xenobiotic_induced0.90710369
79MP0005647_abnormal_sex_gland0.90144286
80MP0003186_abnormal_redox_activity0.88451786
81MP0003300_gastrointestinal_ulcer0.87869553
82MP0005595_abnormal_vascular_smooth0.86801014
83MP0000920_abnormal_myelination0.85852482
84MP0005623_abnormal_meninges_morphology0.83749549
85MP0005535_abnormal_body_temperature0.83241599
86MP0002722_abnormal_immune_system0.80826783
87MP0000249_abnormal_blood_vessel0.76614376
88MP0003646_muscle_fatigue0.67865071
89MP0005266_abnormal_metabolism0.67659277
90MP0008260_abnormal_autophagy0.64688704
91MP0005165_increased_susceptibility_to0.64320539
92MP0001727_abnormal_embryo_implantation0.62757144
93MP0003795_abnormal_bone_structure0.61758738
94MP0001764_abnormal_homeostasis0.61286653
95MP0008875_abnormal_xenobiotic_pharmacok0.60932512
96MP0004858_abnormal_nervous_system0.60367438
97MP0000569_abnormal_digit_pigmentation0.59599060
98MP0005365_abnormal_bile_salt0.58694855
99MP0003183_abnormal_peptide_metabolism0.58458236
100MP0002837_dystrophic_cardiac_calcinosis0.57375258
101MP0005376_homeostasis/metabolism_phenot0.57037509
102MP0002136_abnormal_kidney_physiology0.56092883
103MP0003329_amyloid_beta_deposits0.55357802
104MP0003045_fibrosis0.54711171
105MP0005023_abnormal_wound_healing0.53688566
106MP0008873_increased_physiological_sensi0.52158500
107MP0000371_diluted_coat_color0.51378623
108MP0001663_abnormal_digestive_system0.50026373
109MP0002693_abnormal_pancreas_physiology0.47661587
110MP0003091_abnormal_cell_migration0.45782089
111MP0004782_abnormal_surfactant_physiolog0.45300716
112MP0008874_decreased_physiological_sensi0.44148129
113MP0005451_abnormal_body_composition0.43212101
114MP0000609_abnormal_liver_physiology0.42372025
115MP0002168_other_aberrant_phenotype0.41404631
116MP0001958_emphysema0.39611509
117MP0002295_abnormal_pulmonary_circulatio0.39429384

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.59135336
2Eczematoid dermatitis (HP:0000976)7.15192883
3Stomatitis (HP:0010280)7.10262191
4Recurrent bacterial skin infections (HP:0005406)6.90274487
5Recurrent gram-negative bacterial infections (HP:0005420)6.86939710
6Elevated erythrocyte sedimentation rate (HP:0003565)6.10328902
7Optic neuritis (HP:0100653)5.95149465
8Retrobulbar optic neuritis (HP:0100654)5.95149465
9Orchitis (HP:0100796)5.81021609
10Mediastinal lymphadenopathy (HP:0100721)5.73622669
11Abnormality of macrophages (HP:0004311)5.43603324
12Myositis (HP:0100614)5.35660870
13Systemic lupus erythematosus (HP:0002725)4.67199781
14Interstitial pulmonary disease (HP:0006530)4.37854223
15Gingivitis (HP:0000230)4.28401223
16Loss of speech (HP:0002371)4.20931968
17Recurrent skin infections (HP:0001581)4.09223741
18Chronic obstructive pulmonary disease (HP:0006510)4.07975049
19Obstructive lung disease (HP:0006536)4.07975049
20Nausea (HP:0002018)4.03791514
21Autoimmune thrombocytopenia (HP:0001973)3.87466511
22Nuclear cataract (HP:0100018)3.78838230
23Vasculitis (HP:0002633)3.77249503
24Increased cerebral lipofuscin (HP:0011813)3.70361554
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.70280729
26Neurofibrillary tangles (HP:0002185)3.70225677
27Axonal loss (HP:0003447)3.63493267
28Keratoconjunctivitis sicca (HP:0001097)3.51701573
29Pulmonary infiltrates (HP:0002113)3.51652934
30Mutism (HP:0002300)3.51312811
31Complement deficiency (HP:0004431)3.47346010
32Recurrent fungal infections (HP:0002841)3.43648780
33Vacuolated lymphocytes (HP:0001922)3.40926147
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.22596822
35Keratoconjunctivitis (HP:0001096)3.20468744
36Abnormality of polysaccharide metabolism (HP:0011012)3.20082260
37Abnormality of glycosaminoglycan metabolism (HP:0004371)3.20082260
38Abnormality of mucopolysaccharide metabolism (HP:0011020)3.20082260
39Urticaria (HP:0001025)3.10224187
40Urinary glycosaminoglycan excretion (HP:0003541)3.03083702
41Mucopolysacchariduria (HP:0008155)3.03083702
42Basal ganglia calcification (HP:0002135)2.96417254
43Abnormality of complement system (HP:0005339)2.87279175
44Disinhibition (HP:0000734)2.81631788
45Apathy (HP:0000741)2.81441872
46Tetraparesis (HP:0002273)2.80641180
47Thick nail (HP:0001805)2.79742502
48Periodontitis (HP:0000704)2.78440422
49Abnormality of the pericardium (HP:0001697)2.75923825
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.75113600
51Prostate neoplasm (HP:0100787)2.74537501
52Arterial thrombosis (HP:0004420)2.72903922
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.72662691
54Diminished motivation (HP:0000745)2.72320855
55Fused cervical vertebrae (HP:0002949)2.70056050
56Cellulitis (HP:0100658)2.69724176
57Pustule (HP:0200039)2.69198999
58Abnormality of iron homeostasis (HP:0011031)2.67521627
59Meningitis (HP:0001287)2.66287712
60Recurrent viral infections (HP:0004429)2.60658204
61Petechiae (HP:0000967)2.59353518
62Chronic mucocutaneous candidiasis (HP:0002728)2.51288779
63Recurrent cutaneous fungal infections (HP:0011370)2.51288779
64Leukocytosis (HP:0001974)2.49230943
65Cerebral inclusion bodies (HP:0100314)2.48384400
66Hemoptysis (HP:0002105)2.48219978
67Abnormality of the pleura (HP:0002103)2.46493259
68Progressive neurologic deterioration (HP:0002344)2.42713524
69Purpura (HP:0000979)2.42240026
70Amyloidosis (HP:0011034)2.41803162
71Anorexia (HP:0002039)2.40622818
72Poor head control (HP:0002421)2.40196024
73Joint swelling (HP:0001386)2.38874386
74Autoimmune hemolytic anemia (HP:0001890)2.37740345
75Metaphyseal irregularity (HP:0003025)2.32107172
76Recurrent pneumonia (HP:0006532)2.30774680
77Parakeratosis (HP:0001036)2.30180727
78Myocardial infarction (HP:0001658)2.30090712
79Joint hemorrhage (HP:0005261)2.29544941
80Agnosia (HP:0010524)2.29440721
81Glomerulonephritis (HP:0000099)2.28887844
82Inappropriate behavior (HP:0000719)2.28731354
83Neuronal loss in central nervous system (HP:0002529)2.23329795
84Nephritis (HP:0000123)2.23071582
85Abnormality of transition element cation homeostasis (HP:0011030)2.22779710
86Hemorrhage of the eye (HP:0011885)2.22582450
87Increased IgM level (HP:0003496)2.22173322
88Increased IgE level (HP:0003212)2.21511078
89Hepatosplenomegaly (HP:0001433)2.20680407
90Bone pain (HP:0002653)2.20428111
91Arthralgia (HP:0002829)2.19452788
92Malnutrition (HP:0004395)2.16153571
93Osteomyelitis (HP:0002754)2.14927417
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14600141
95Gingival bleeding (HP:0000225)2.11340688
96Gangrene (HP:0100758)2.11144946
97Vertebral compression fractures (HP:0002953)2.10278912
98Asymmetric septal hypertrophy (HP:0001670)2.09463509
99Prolonged neonatal jaundice (HP:0006579)2.08001534
100Dysostosis multiplex (HP:0000943)2.06351098
101Episodic fever (HP:0001954)2.04601612
102Progressive visual loss (HP:0000529)2.01278171
103Recurrent lower respiratory tract infections (HP:0002783)2.00910869
104Hematochezia (HP:0002573)1.99447841
105Pulmonary embolism (HP:0002204)1.97997991
106Increased CSF protein (HP:0002922)1.97275629
107Abnormality of glycolipid metabolism (HP:0010969)1.94758013
108Abnormality of liposaccharide metabolism (HP:0010968)1.94758013
109Abnormality of glycosphingolipid metabolism (HP:0004343)1.94758013
110Porencephaly (HP:0002132)1.92350404
111Steatorrhea (HP:0002570)1.91180657
112Peritonitis (HP:0002586)1.88456501
113Stenosis of the external auditory canal (HP:0000402)1.87602984
114Premature loss of primary teeth (HP:0006323)1.87563507
115Pathologic fracture (HP:0002756)1.86632715
116Encephalitis (HP:0002383)1.85568389
117Alveolar cell carcinoma (HP:0006519)1.85233058
118Acne (HP:0001061)1.84172251
119Hypergammaglobulinemia (HP:0010702)1.83788817
120Segmental peripheral demyelination/remyelination (HP:0003481)1.82911599
121Abnormality of proline metabolism (HP:0010907)1.81502394
122Hydroxyprolinuria (HP:0003080)1.81502394
123Xerostomia (HP:0000217)1.81227529
124Dementia (HP:0000726)1.81159536
125Vertigo (HP:0002321)1.80847462
126Memory impairment (HP:0002354)1.80740254
127Conjunctival telangiectasia (HP:0000524)1.80216301
128Prolonged bleeding time (HP:0003010)1.80140785
129Gastrointestinal infarctions (HP:0005244)1.80031475
130Abnormality of the nasal septum (HP:0000419)1.79993146
131Esophageal neoplasm (HP:0100751)1.78258928
132Neoplasm of head and neck (HP:0012288)1.78258928
133Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77968342
134Peripheral demyelination (HP:0011096)1.77719614
135Increased serum ferritin (HP:0003281)1.77526385
136Cardiomegaly (HP:0001640)1.75816314
137Pigmentary retinal degeneration (HP:0001146)1.74531810
138Epistaxis (HP:0000421)1.73073022
139Lower limb hyperreflexia (HP:0002395)1.71748119
140Polyneuropathy (HP:0001271)1.71567896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.79869773
2IRAK34.35804536
3BLK4.33533270
4RIPK44.30550069
5TBK14.27977540
6TXK4.05459908
7MAP3K33.20724443
8IRAK43.00553784
9MAP4K12.85109189
10ERN12.76809090
11IKBKB2.71053904
12DDR22.61534844
13IKBKE2.57199720
14TAOK12.54877260
15PBK2.54800205
16FGR2.43202537
17MAP2K32.16447649
18TYK21.96458610
19MAP3K131.91266912
20CSK1.79602233
21ADRBK21.76720265
22CHUK1.67170922
23JAK31.61925723
24PIM21.59357759
25BMX1.50311372
26ZAP701.34920077
27PRPF4B1.34433379
28GRK71.34110831
29JAK11.28371189
30ERBB41.27143720
31ABL21.26952021
32LYN1.25678387
33KIT1.25080096
34MAP3K121.23918255
35HCK1.17481635
36MAPK151.15224899
37LATS21.13522845
38SYK1.11877946
39CDC42BPA1.10153609
40BMPR21.09448327
41CSF1R1.05182599
42STK101.03123534
43MST1R1.02014846
44PIM11.01775935
45EIF2AK21.01307932
46MARK31.01012115
47FES0.97360710
48LCK0.97188629
49MAP3K50.87292681
50PDK20.86156435
51EPHB10.83982963
52MATK0.83911852
53PRKCD0.82995859
54ARAF0.81396696
55JAK20.79291192
56YES10.79140955
57BTK0.76663025
58RPS6KA40.75725693
59ABL10.73878600
60IRAK20.70223337
61CAMKK20.68486245
62SIK20.68130869
63MST40.68091488
64EGFR0.63001827
65SIK30.60859587
66TAOK30.59601572
67MUSK0.59030302
68MAP2K60.58847192
69DAPK30.57579048
70MAP3K110.56888888
71NEK90.55430870
72ADRBK10.54136086
73CLK10.53678209
74STK240.53434952
75TYRO30.52777771
76LRRK20.52637893
77FYN0.50808802
78PDGFRA0.49235605
79DYRK30.45625780
80BMPR1B0.44917764
81RIPK10.43568908
82PAK40.43296629
83TEC0.43181182
84PDGFRB0.42466716
85TAOK20.42355260
86TGFBR20.41384640
87IRAK10.40085318
88DAPK20.40080435
89TTN0.39580672
90EPHA30.39212249
91MAPK70.38611544
92GSK3A0.38026030
93NUAK10.36841266
94PRKG20.33996966
95SIK10.33535171
96MAP3K10.32950429
97EIF2AK30.32688669
98NME20.32109281
99ACVR1B0.31689007
100PTK60.31017504
101MAPKAPK20.30680711
102INSR0.30469904
103STK40.29385792
104RPS6KL10.27920912
105RPS6KC10.27920912
106MAP3K100.27284162
107PRKCQ0.27269859
108CDK60.26711732
109STK30.26150661
110TESK10.25619890
111CAMK1D0.23908365
112TRPM70.23429169
113MOS0.22729363
114RPS6KA10.22474031
115PKN10.22368210
116ERBB30.21933233
117IGF1R0.21636773
118HIPK20.21262353
119PRKCH0.20193789
120PLK20.19792886
121KSR20.19257799
122ITK0.18897306
123PDPK10.18591301
124MAPK40.18105792
125MAP3K90.17534664
126PRKCE0.16540793
127LMTK20.15636439
128TESK20.15006343
129PDK10.14256934
130RPS6KA60.14211298

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.37205550
2Type I diabetes mellitus_Homo sapiens_hsa049403.69977976
3Leishmaniasis_Homo sapiens_hsa051403.57910110
4Rheumatoid arthritis_Homo sapiens_hsa053233.28844784
5Allograft rejection_Homo sapiens_hsa053303.18748026
6Toll-like receptor signaling pathway_Homo sapiens_hsa046203.06248081
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.88405706
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.81678037
9* Legionellosis_Homo sapiens_hsa051342.79792384
10Pertussis_Homo sapiens_hsa051332.74989247
11Staphylococcus aureus infection_Homo sapiens_hsa051502.71370351
12Malaria_Homo sapiens_hsa051442.67059427
13Asthma_Homo sapiens_hsa053102.55191574
14* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.54996725
15Tuberculosis_Homo sapiens_hsa051522.43968647
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.38025093
17* NF-kappa B signaling pathway_Homo sapiens_hsa040642.37357816
18African trypanosomiasis_Homo sapiens_hsa051432.18442083
19Osteoclast differentiation_Homo sapiens_hsa043802.16718639
20* Salmonella infection_Homo sapiens_hsa051322.05963922
21Hematopoietic cell lineage_Homo sapiens_hsa046401.96653332
22* TNF signaling pathway_Homo sapiens_hsa046681.92548333
23Measles_Homo sapiens_hsa051621.74964005
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.67447648
25Influenza A_Homo sapiens_hsa051641.61310592
26* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58427306
27Phagosome_Homo sapiens_hsa041451.36242938
28Amoebiasis_Homo sapiens_hsa051461.28215230
29Autoimmune thyroid disease_Homo sapiens_hsa053201.27065689
30Prion diseases_Homo sapiens_hsa050201.26027719
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.25119274
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24850726
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22454003
34Herpes simplex infection_Homo sapiens_hsa051681.21424527
35Bladder cancer_Homo sapiens_hsa052191.15550789
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.08899683
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08878785
38Toxoplasmosis_Homo sapiens_hsa051451.08238467
39Lysosome_Homo sapiens_hsa041421.07496254
40* Chemokine signaling pathway_Homo sapiens_hsa040621.01047924
41Hepatitis B_Homo sapiens_hsa051610.95530715
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92034788
43Hepatitis C_Homo sapiens_hsa051600.90610972
44B cell receptor signaling pathway_Homo sapiens_hsa046620.84567660
45Apoptosis_Homo sapiens_hsa042100.81650324
46Shigellosis_Homo sapiens_hsa051310.80360513
47Sulfur metabolism_Homo sapiens_hsa009200.74048037
48Collecting duct acid secretion_Homo sapiens_hsa049660.73424927
49Complement and coagulation cascades_Homo sapiens_hsa046100.71346714
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70519107
51Antigen processing and presentation_Homo sapiens_hsa046120.65348708
52Viral myocarditis_Homo sapiens_hsa054160.63206401
53Mineral absorption_Homo sapiens_hsa049780.60493941
54T cell receptor signaling pathway_Homo sapiens_hsa046600.59756498
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.58351091
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57214805
57Type II diabetes mellitus_Homo sapiens_hsa049300.54523142
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53387603
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51578179
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51347797
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.46036382
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45045461
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.43235343
64Other glycan degradation_Homo sapiens_hsa005110.41655338
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40325727
66PPAR signaling pathway_Homo sapiens_hsa033200.38481852
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36901812
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.35420965
69Tryptophan metabolism_Homo sapiens_hsa003800.34114032
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31252000
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29128883
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28990396
73Renal cell carcinoma_Homo sapiens_hsa052110.28809922
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.26832633
75Galactose metabolism_Homo sapiens_hsa000520.26478676
76Epstein-Barr virus infection_Homo sapiens_hsa051690.25303802
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24695090
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.24413071
79Platelet activation_Homo sapiens_hsa046110.23578790
80HIF-1 signaling pathway_Homo sapiens_hsa040660.22001454
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20420409
82Dorso-ventral axis formation_Homo sapiens_hsa043200.19337805
83Insulin resistance_Homo sapiens_hsa049310.19270751
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18864846
85Chronic myeloid leukemia_Homo sapiens_hsa052200.18195820
86Acute myeloid leukemia_Homo sapiens_hsa052210.17888399
87MAPK signaling pathway_Homo sapiens_hsa040100.17132170
88Small cell lung cancer_Homo sapiens_hsa052220.17032626
89Vibrio cholerae infection_Homo sapiens_hsa051100.15725581
90Proteoglycans in cancer_Homo sapiens_hsa052050.15407321
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11809575
92Systemic lupus erythematosus_Homo sapiens_hsa053220.11787713
93Pancreatic cancer_Homo sapiens_hsa052120.11189201
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10961728
95Arachidonic acid metabolism_Homo sapiens_hsa005900.10767349
96VEGF signaling pathway_Homo sapiens_hsa043700.10408669
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09449919
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09314123
99Synaptic vesicle cycle_Homo sapiens_hsa047210.08054615
100Primary immunodeficiency_Homo sapiens_hsa053400.07735227
101Renin-angiotensin system_Homo sapiens_hsa046140.07673032
102Prolactin signaling pathway_Homo sapiens_hsa049170.06594363
103FoxO signaling pathway_Homo sapiens_hsa040680.05764592
104Endocytosis_Homo sapiens_hsa041440.04259310
105mTOR signaling pathway_Homo sapiens_hsa041500.04237946
106HTLV-I infection_Homo sapiens_hsa051660.04053362
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.02142490
108Sphingolipid metabolism_Homo sapiens_hsa006000.01663144
109PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0410772
110Caffeine metabolism_Homo sapiens_hsa00232-0.0376261
111TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0353972
112Notch signaling pathway_Homo sapiens_hsa04330-0.0251799
113MicroRNAs in cancer_Homo sapiens_hsa05206-0.0200076
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0161594
115Viral carcinogenesis_Homo sapiens_hsa05203-0.0087697

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