CXCL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type I interferon signaling pathway (GO:0060337)6.00684645
2cellular response to type I interferon (GO:0071357)6.00684645
3response to type I interferon (GO:0034340)5.92567181
4regulation of chronic inflammatory response (GO:0002676)5.65954518
5positive regulation of interferon-alpha production (GO:0032727)5.57101011
6response to interferon-alpha (GO:0035455)5.30578227
7regulation of interferon-alpha production (GO:0032647)5.25120253
8positive regulation by symbiont of host defense response (GO:0052509)5.20395508
9modulation by symbiont of host defense response (GO:0052031)5.20395508
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.20395508
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.20395508
12positive regulation by organism of defense response of other organism involved in symbiotic interact5.20395508
13modulation by symbiont of host immune response (GO:0052553)5.20395508
14negative regulation of viral genome replication (GO:0045071)5.17950512
15cellular response to interferon-alpha (GO:0035457)5.15791347
16cellular response to exogenous dsRNA (GO:0071360)4.90237503
17regulation of dendritic cell antigen processing and presentation (GO:0002604)4.84648673
18positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.74705175
19negative regulation of interleukin-12 production (GO:0032695)4.65799912
20regulation of type 2 immune response (GO:0002828)4.57883284
21regulation of vitamin D biosynthetic process (GO:0060556)4.54146896
22regulation of T cell tolerance induction (GO:0002664)4.37003049
23positive regulation of antigen processing and presentation (GO:0002579)4.31708924
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.28565239
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28565239
26antigen processing and presentation of endogenous antigen (GO:0019883)4.25773038
27positive regulation of toll-like receptor signaling pathway (GO:0034123)4.23405814
28response to peptidoglycan (GO:0032494)4.20333620
29response to host immune response (GO:0052572)4.19631910
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.19631910
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.17895126
32regulation of MHC class I biosynthetic process (GO:0045343)4.14938712
33immunoglobulin mediated immune response (GO:0016064)4.13521328
34positive regulation of type 2 immune response (GO:0002830)4.08732251
35natural killer cell activation involved in immune response (GO:0002323)3.98102436
36T-helper 1 type immune response (GO:0042088)3.97932802
37kynurenine metabolic process (GO:0070189)3.95898466
38* positive regulation of cAMP-mediated signaling (GO:0043950)3.89290592
39cellular response to virus (GO:0098586)3.88223616
40hydrogen peroxide biosynthetic process (GO:0050665)3.87376282
41positive regulation of T-helper cell differentiation (GO:0045624)3.86080650
42regulation of cytokine secretion involved in immune response (GO:0002739)3.84951841
43regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.84168183
44positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.84168183
45regulation of antigen processing and presentation (GO:0002577)3.83183621
46interferon-gamma-mediated signaling pathway (GO:0060333)3.80328640
47positive regulation of defense response to virus by host (GO:0002230)3.78389264
48positive regulation of interferon-beta production (GO:0032728)3.78293837
49regulation of interleukin-12 production (GO:0032655)3.75422413
50regulation of T-helper cell differentiation (GO:0045622)3.75245709
51indole-containing compound catabolic process (GO:0042436)3.74909188
52indolalkylamine catabolic process (GO:0046218)3.74909188
53tryptophan catabolic process (GO:0006569)3.74909188
54positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.73149340
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.69107198
56response to host (GO:0075136)3.69107198
57response to host defenses (GO:0052200)3.69107198
58neutrophil activation involved in immune response (GO:0002283)3.66594989
59regulation of tolerance induction (GO:0002643)3.64224442
60regulation of vitamin metabolic process (GO:0030656)3.64071932
61negative regulation of myeloid cell apoptotic process (GO:0033033)3.63019815
62positive regulation of cellular amide metabolic process (GO:0034250)3.60735575
63positive regulation of gamma-delta T cell activation (GO:0046645)3.60063827
64positive regulation of tolerance induction (GO:0002645)3.59563065
65positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.55015098
66positive regulation of natural killer cell differentiation (GO:0032825)3.54807632
67superoxide anion generation (GO:0042554)3.51931284
68regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.50835099
69defense response to virus (GO:0051607)3.49089896
70regulation of T-helper 1 cell differentiation (GO:0045625)3.47149575
71NIK/NF-kappaB signaling (GO:0038061)3.46917558
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.46563119
73production of molecular mediator involved in inflammatory response (GO:0002532)3.45049170
74negative regulation of cytokine production involved in immune response (GO:0002719)3.43943231
75response to interferon-beta (GO:0035456)3.43470636
76regulation of activation of Janus kinase activity (GO:0010533)3.42827149
77* lymphocyte chemotaxis (GO:0048247)3.41797771
78regulation of interferon-beta biosynthetic process (GO:0045357)3.40142078
79reactive oxygen species biosynthetic process (GO:1903409)3.39890802
80regulation of RIG-I signaling pathway (GO:0039535)3.38088384
81macrophage activation involved in immune response (GO:0002281)3.37852234
82negative regulation of T cell mediated immunity (GO:0002710)3.35524364
83positive regulation of heat generation (GO:0031652)3.35007234
84positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.34731640
85detection of molecule of bacterial origin (GO:0032490)3.34649424
86microglial cell activation (GO:0001774)3.32509974
87JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.31373073
88dendritic cell differentiation (GO:0097028)3.30055081
89positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.29323608
90natural killer cell mediated immunity (GO:0002228)3.28189420
91natural killer cell mediated cytotoxicity (GO:0042267)3.28189420
92positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.26559631
93lipopolysaccharide-mediated signaling pathway (GO:0031663)3.26159264
94regulation of response to interferon-gamma (GO:0060330)3.25916265
95regulation of type I interferon-mediated signaling pathway (GO:0060338)3.25619157
96interferon-gamma secretion (GO:0072643)3.24330774
97cellular response to interferon-gamma (GO:0071346)3.24312145
98positive regulation of interleukin-17 production (GO:0032740)3.23362016
99defense response to protozoan (GO:0042832)3.22086879
100negative regulation of interleukin-10 production (GO:0032693)3.21576010
101negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.21141695
102regulation of fever generation (GO:0031620)3.20930286
103response to interferon-gamma (GO:0034341)3.20461328
104positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.20456910
105cellular response to lipopolysaccharide (GO:0071222)3.20046862
106regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.13996722
107regulation of interferon-gamma biosynthetic process (GO:0045072)3.11858411
108cellular response to interferon-beta (GO:0035458)3.11275431
109cellular response to molecule of bacterial origin (GO:0071219)3.11136553
110respiratory burst (GO:0045730)3.10922546
111branching involved in labyrinthine layer morphogenesis (GO:0060670)3.10266243
112negative regulation of type I interferon production (GO:0032480)3.09603312
113regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.07988562
114NAD biosynthetic process (GO:0009435)3.06733083
115regulation of T-helper 1 type immune response (GO:0002825)3.06438219
116JAK-STAT cascade (GO:0007259)3.05892682
117B cell mediated immunity (GO:0019724)3.05659717
118regulation of interleukin-1 beta secretion (GO:0050706)3.05627286
119myeloid dendritic cell activation (GO:0001773)3.04901535
120positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.04724017
121positive regulation of interleukin-12 production (GO:0032735)3.04488290
122positive regulation of NF-kappaB import into nucleus (GO:0042346)3.03544797
123positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.03166645
124regulation of mononuclear cell migration (GO:0071675)3.01975209
125positive regulation of chemokine biosynthetic process (GO:0045080)3.01419227
126regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.01117493
127granulocyte activation (GO:0036230)2.99890356
128regulation of podosome assembly (GO:0071801)2.99552588
129myeloid dendritic cell differentiation (GO:0043011)2.99525090
130response to protozoan (GO:0001562)2.99212924
131regulation of defense response to virus by host (GO:0050691)2.95715737
132neutrophil activation (GO:0042119)2.94153228
133positive regulation of T cell cytokine production (GO:0002726)2.89670369
134regulation of toll-like receptor signaling pathway (GO:0034121)2.88757586
135triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.88490959
136regulation of viral genome replication (GO:0045069)2.86409818
137intracellular pH reduction (GO:0051452)2.79971950
138regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.79025854
139negative regulation of viral process (GO:0048525)2.78536187
140response to muramyl dipeptide (GO:0032495)2.78385166
141detection of external biotic stimulus (GO:0098581)2.77852212
142regulation of heat generation (GO:0031650)2.71907705
143detection of other organism (GO:0098543)2.71274696
144macrophage activation (GO:0042116)2.70292705
145regulation of interferon-beta production (GO:0032648)2.69816757
146detection of bacterium (GO:0016045)2.69581240
147positive regulation of T cell migration (GO:2000406)2.68083737
148arginine catabolic process (GO:0006527)2.66334179
149* T cell migration (GO:0072678)2.65278972
150regulation of interleukin-8 biosynthetic process (GO:0045414)2.64470659
151response to exogenous dsRNA (GO:0043330)2.63661071
152positive regulation of lymphocyte migration (GO:2000403)2.62871731
153nicotinamide nucleotide biosynthetic process (GO:0019359)2.60695635
154pyridine nucleotide biosynthetic process (GO:0019363)2.60695635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.63414916
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human7.39452521
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.56298949
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.01902355
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.81334223
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.45472581
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.30110529
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.21827327
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91760403
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.88496553
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86711038
12* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.70624365
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63444770
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.53610376
15GATA1_22025678_ChIP-Seq_K562_Human2.40543583
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.37550894
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31796928
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20757091
19* LXR_22158963_ChIP-Seq_LIVER_Mouse2.11672491
20* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.08021211
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05844260
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.01879782
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00188971
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97725595
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77120200
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71072245
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70172875
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67039467
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.63981391
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62736803
31* MYB_26560356_Chip-Seq_TH2_Human1.46060629
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42584011
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42142532
34MAF_26560356_Chip-Seq_TH1_Human1.36621639
35SPI1_23127762_ChIP-Seq_K562_Human1.33214720
36EGR1_19032775_ChIP-ChIP_M12_Human1.32331278
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29144538
38VDR_24763502_ChIP-Seq_THP-1_Human1.28610332
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22734714
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21468805
41VDR_24787735_ChIP-Seq_THP-1_Human1.20633351
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.20382502
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.19827995
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19226620
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19107880
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18724470
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17482187
48SCL_19346495_ChIP-Seq_HPC-7_Human1.17171524
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14707255
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14619461
51MYB_26560356_Chip-Seq_TH1_Human1.11900014
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11312597
53PU_27001747_Chip-Seq_BMDM_Mouse1.10917578
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02146714
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02146714
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.01114508
57SOX2_20726797_ChIP-Seq_SW620_Human0.98635552
58GATA3_27048872_Chip-Seq_THYMUS_Human0.97807352
59TRIM28_21343339_ChIP-Seq_HEK293_Human0.96179054
60VDR_22108803_ChIP-Seq_LS180_Human0.95504233
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95347568
62* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95260825
63STAT1_20625510_ChIP-Seq_HELA_Human0.94751195
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93607241
65RUNX_20019798_ChIP-Seq_JUKART_Human0.93022112
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90167676
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88300088
68BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88190277
69GATA3_26560356_Chip-Seq_TH2_Human0.86453680
70IGF1R_20145208_ChIP-Seq_DFB_Human0.85787663
71VDR_21846776_ChIP-Seq_THP-1_Human0.85538464
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84957979
73GATA1_19941827_ChIP-Seq_MEL_Mouse0.84847840
74KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83879845
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83784297
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82816354
77CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82308660
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81995709
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81808878
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81808878
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81808878
82GBX2_23144817_ChIP-Seq_PC3_Human0.81278633
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.80887344
84SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80817875
85STAT3_18555785_Chip-Seq_ESCs_Mouse0.80560227
86GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79575799
87RUNX1_27457419_Chip-Seq_LIVER_Mouse0.78792233
88SPI1_23547873_ChIP-Seq_NB4_Human0.78438234
89GATA1_19941826_ChIP-Seq_K562_Human0.77727796
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76684563
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76042401
92PU1_27457419_Chip-Seq_LIVER_Mouse0.75842788
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75769744
94MAF_26560356_Chip-Seq_TH2_Human0.75641582
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75568003
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.75072664
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74424055
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.73845460
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.73723338
100* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73479206
101CMYC_18555785_Chip-Seq_ESCs_Mouse0.72567128
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.72327106
103KDM2B_26808549_Chip-Seq_DND41_Human0.72290507
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.71236585
105UTX_26944678_Chip-Seq_JUKART_Human0.70987751
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.70814919
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.70648765
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.70519820
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70130391
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68824886
111OCT4_18555785_Chip-Seq_ESCs_Mouse0.68788140
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68751689
113P300_19829295_ChIP-Seq_ESCs_Human0.68734431
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.68588838
115ESRRB_18555785_Chip-Seq_ESCs_Mouse0.68204000
116SMAD1_18555785_Chip-Seq_ESCs_Mouse0.67769618
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67184137
118P53_22387025_ChIP-Seq_ESCs_Mouse0.67180511
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66786497
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.66534943
121E2F1_18555785_Chip-Seq_ESCs_Mouse0.66375901
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.66267744
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.66261362
124NMYC_18555785_Chip-Seq_ESCs_Mouse0.66260273
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.66157382
126SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.65925005
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.65116327
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64974940
129CTCF_18555785_Chip-Seq_ESCs_Mouse0.64799753
130TAF15_26573619_Chip-Seq_HEK293_Human0.64524426
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.64466803
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.64107133
133ZFX_18555785_Chip-Seq_ESCs_Mouse0.63245159
134PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.62457332
135TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.62069844
136RUNX1_22412390_ChIP-Seq_EML_Mouse0.61897420
137TFEB_21752829_ChIP-Seq_HELA_Human0.61758229
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61587698
139* TCF7_22412390_ChIP-Seq_EML_Mouse0.59685253
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.59298039
141LXR_22292898_ChIP-Seq_THP-1_Human0.56823932
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54935905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.35060250
2MP0009785_altered_susceptibility_to3.88774101
3MP0006082_CNS_inflammation3.40347434
4MP0003724_increased_susceptibility_to3.37912776
5MP0004510_myositis3.28633219
6MP0002148_abnormal_hypersensitivity_rea3.12662429
7MP0003436_decreased_susceptibility_to3.10202048
8MP0002139_abnormal_hepatobiliary_system3.00455035
9MP0000685_abnormal_immune_system2.95087871
10MP0005387_immune_system_phenotype2.89546559
11MP0001790_abnormal_immune_system2.89546559
12MP0005025_abnormal_response_to2.88062512
13MP0005671_abnormal_response_to2.64043975
14MP0002419_abnormal_innate_immunity2.63175723
15MP0005360_urolithiasis2.55344175
16MP0005000_abnormal_immune_tolerance2.52940894
17MP0009764_decreased_sensitivity_to2.49938471
18MP0002254_reproductive_system_inflammat2.32935913
19MP0001800_abnormal_humoral_immune2.32436616
20MP0003303_peritoneal_inflammation2.20691035
21MP0002452_abnormal_antigen_presenting2.14940498
22MP0002723_abnormal_immune_serum2.14424277
23MP0004782_abnormal_surfactant_physiolog2.02485376
24MP0001533_abnormal_skeleton_physiology1.97862006
25MP0009840_abnormal_foam_cell1.96908510
26MP0005085_abnormal_gallbladder_physiolo1.95390634
27MP0002277_abnormal_respiratory_mucosa1.85952560
28MP0001853_heart_inflammation1.85803028
29MP0002138_abnormal_hepatobiliary_system1.83979667
30MP0005365_abnormal_bile_salt1.82984939
31MP0008469_abnormal_protein_level1.82796512
32MP0001819_abnormal_immune_cell1.74063855
33MP0003172_abnormal_lysosome_physiology1.71928765
34MP0002876_abnormal_thyroid_physiology1.70055149
35MP0001845_abnormal_inflammatory_respons1.68941174
36MP0005464_abnormal_platelet_physiology1.67362949
37MP0002420_abnormal_adaptive_immunity1.67150779
38MP0004947_skin_inflammation1.67021826
39MP0004858_abnormal_nervous_system1.60794017
40MP0003075_altered_response_to1.59735330
41MP0003195_calcinosis1.56377639
42MP0005310_abnormal_salivary_gland1.54709633
43MP0005058_abnormal_lysosome_morphology1.51209495
44MP0003186_abnormal_redox_activity1.49742909
45MP0003191_abnormal_cellular_cholesterol1.43465105
46MP0003448_altered_tumor_morphology1.42309101
47MP0008875_abnormal_xenobiotic_pharmacok1.41127780
48MP0010155_abnormal_intestine_physiology1.36149732
49MP0006054_spinal_hemorrhage1.34604535
50MP0000604_amyloidosis1.31631120
51MP0003806_abnormal_nucleotide_metabolis1.29274535
52MP0005083_abnormal_biliary_tract1.28952122
53MP0000343_altered_response_to1.26755505
54MP0009763_increased_sensitivity_to1.19165511
55MP0009278_abnormal_bone_marrow1.18544116
56MP0001764_abnormal_homeostasis1.15966850
57MP0010329_abnormal_lipoprotein_level1.14484395
58MP0000716_abnormal_immune_system1.14378607
59MP0002998_abnormal_bone_remodeling1.12948248
60MP0003252_abnormal_bile_duct1.10721945
61MP0005319_abnormal_enzyme/_coenzyme1.10704871
62MP0009333_abnormal_splenocyte_physiolog1.09180043
63MP0005451_abnormal_body_composition1.08493174
64MP0005332_abnormal_amino_acid1.08410410
65MP0003646_muscle_fatigue1.08085392
66MP0001501_abnormal_sleep_pattern1.07743428
67MP0005164_abnormal_response_to1.06726659
68MP0005171_absent_coat_pigmentation1.03998872
69MP0003690_abnormal_glial_cell1.03629250
70MP0000609_abnormal_liver_physiology1.02974113
71MP0001346_abnormal_lacrimal_gland1.00559435
72MP0000920_abnormal_myelination0.96885584
73MP0003183_abnormal_peptide_metabolism0.95508219
74MP0002006_tumorigenesis0.94332961
75MP0009697_abnormal_copulation0.93843661
76MP0002405_respiratory_system_inflammati0.93472588
77MP0005584_abnormal_enzyme/coenzyme_acti0.93161971
78MP0008260_abnormal_autophagy0.92461542
79MP0005166_decreased_susceptibility_to0.90270033
80MP0009765_abnormal_xenobiotic_induced0.89862820
81MP0002398_abnormal_bone_marrow0.89840424
82MP0003763_abnormal_thymus_physiology0.88916782
83MP0003091_abnormal_cell_migration0.88835817
84MP0003011_delayed_dark_adaptation0.88654391
85MP0005248_abnormal_Harderian_gland0.86733677
86MP0005390_skeleton_phenotype0.86264034
87MP0002429_abnormal_blood_cell0.84157651
88MP0002722_abnormal_immune_system0.84000827
89MP0003221_abnormal_cardiomyocyte_apopto0.83862383
90MP0004019_abnormal_vitamin_homeostasis0.83622406
91MP0002166_altered_tumor_susceptibility0.83393870
92MP0002118_abnormal_lipid_homeostasis0.80246523
93MP0005647_abnormal_sex_gland0.75838194
94MP0000858_altered_metastatic_potential0.74923262
95MP0010352_gastrointestinal_tract_polyps0.74317775
96MP0003453_abnormal_keratinocyte_physiol0.74309700
97MP0008004_abnormal_stomach_pH0.74296596
98MP0008874_decreased_physiological_sensi0.73161243
99MP0003656_abnormal_erythrocyte_physiolo0.72393055
100MP0005645_abnormal_hypothalamus_physiol0.71954119
101MP0004883_abnormal_blood_vessel0.71544779
102MP0001542_abnormal_bone_strength0.71492652
103MP0005165_increased_susceptibility_to0.70994818
104MP0001881_abnormal_mammary_gland0.70994070
105MP0001663_abnormal_digestive_system0.69208651
106MP0003300_gastrointestinal_ulcer0.69032402
107MP0002332_abnormal_exercise_endurance0.68982737
108MP0004808_abnormal_hematopoietic_stem0.68732770
109MP0005167_abnormal_blood-brain_barrier0.68642022
110MP0010386_abnormal_urinary_bladder0.68223421
111MP0001873_stomach_inflammation0.67026582
112MP0000372_irregular_coat_pigmentation0.66391352
113MP0000689_abnormal_spleen_morphology0.65139035
114MP0002090_abnormal_vision0.64292668
115MP0001545_abnormal_hematopoietic_system0.63792368
116MP0005397_hematopoietic_system_phenotyp0.63792368
117MP0002136_abnormal_kidney_physiology0.62605957
118MP0005266_abnormal_metabolism0.60543844
119MP0005535_abnormal_body_temperature0.60291764
120MP0001348_abnormal_lacrimal_gland0.59435994
121MP0002163_abnormal_gland_morphology0.58784411
122MP0002933_joint_inflammation0.54184789
123MP0002877_abnormal_melanocyte_morpholog0.54124153
124MP0000249_abnormal_blood_vessel0.53628967
125MP0002693_abnormal_pancreas_physiology0.52676685
126MP0005023_abnormal_wound_healing0.52063351
127MP0003795_abnormal_bone_structure0.51037779
128MP0005666_abnormal_adipose_tissue0.50522208

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.44998101
2Recurrent gram-negative bacterial infections (HP:0005420)5.29397820
3Recurrent bacterial skin infections (HP:0005406)5.18216101
4Recurrent abscess formation (HP:0002722)5.14869223
5Autoimmune thrombocytopenia (HP:0001973)4.43879794
6Tetraparesis (HP:0002273)4.37823001
7Systemic lupus erythematosus (HP:0002725)4.35288227
8Increased IgM level (HP:0003496)4.26938582
9Abnormality of macrophages (HP:0004311)3.98272996
10Elevated erythrocyte sedimentation rate (HP:0003565)3.92113197
11Hemoptysis (HP:0002105)3.82237946
12Mediastinal lymphadenopathy (HP:0100721)3.76536353
13Chronic otitis media (HP:0000389)3.73378541
14Basal ganglia calcification (HP:0002135)3.69650115
15Gingivitis (HP:0000230)3.69181082
16Orchitis (HP:0100796)3.59295761
17Recurrent skin infections (HP:0001581)3.54713279
18Gangrene (HP:0100758)3.51235902
19Myositis (HP:0100614)3.47137955
20Retrobulbar optic neuritis (HP:0100654)3.43306820
21Optic neuritis (HP:0100653)3.43306820
22Prostate neoplasm (HP:0100787)3.34424321
23Disinhibition (HP:0000734)3.31665619
24Hematochezia (HP:0002573)3.29870521
25Dysostosis multiplex (HP:0000943)3.23235852
26Vasculitis (HP:0002633)3.22983655
27Stomatitis (HP:0010280)3.17257028
28Joint hemorrhage (HP:0005261)3.14570347
29T lymphocytopenia (HP:0005403)3.08333420
30Premature loss of primary teeth (HP:0006323)3.08091319
31Abnormality of T cell number (HP:0011839)3.07362836
32Abnormality of proline metabolism (HP:0010907)2.97918204
33Hydroxyprolinuria (HP:0003080)2.97918204
34Hypergammaglobulinemia (HP:0010702)2.97719668
35Recurrent fungal infections (HP:0002841)2.91885633
36Prolonged neonatal jaundice (HP:0006579)2.91712996
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87256298
38Gingival bleeding (HP:0000225)2.83336703
39Urticaria (HP:0001025)2.82187617
40Intrahepatic cholestasis (HP:0001406)2.81730318
41Parakeratosis (HP:0001036)2.81106236
42Periodontitis (HP:0000704)2.80096097
43Prolonged partial thromboplastin time (HP:0003645)2.78372886
44Xanthomatosis (HP:0000991)2.77271586
45Encephalitis (HP:0002383)2.68744518
46Myocardial infarction (HP:0001658)2.68376568
47Recurrent cutaneous fungal infections (HP:0011370)2.67770347
48Chronic mucocutaneous candidiasis (HP:0002728)2.67770347
49Abnormality of B cell number (HP:0010975)2.64854557
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.64146510
51Recurrent viral infections (HP:0004429)2.60194344
52Increased cerebral lipofuscin (HP:0011813)2.58132157
53Abnormality of polysaccharide metabolism (HP:0011012)2.57902022
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57902022
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57902022
56Abnormality of the endocardium (HP:0004306)2.56434852
57Complement deficiency (HP:0004431)2.52902261
58Hyperlipoproteinemia (HP:0010980)2.51005774
59Glomerulonephritis (HP:0000099)2.50691641
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.49436310
61Progressive neurologic deterioration (HP:0002344)2.47630233
62Urinary glycosaminoglycan excretion (HP:0003541)2.47379770
63Mucopolysacchariduria (HP:0008155)2.47379770
64Mutism (HP:0002300)2.46437758
65Recurrent pneumonia (HP:0006532)2.44695989
66Vacuolated lymphocytes (HP:0001922)2.44524103
67Pustule (HP:0200039)2.43711109
68Chronic obstructive pulmonary disease (HP:0006510)2.43295597
69Obstructive lung disease (HP:0006536)2.43295597
70Polyneuropathy (HP:0001271)2.41915127
71Abnormality of the pleura (HP:0002103)2.40376998
72Joint swelling (HP:0001386)2.40056773
73Chronic sinusitis (HP:0011109)2.37472014
74Epidermoid cyst (HP:0200040)2.37266563
75Thick nail (HP:0001805)2.36412427
76Pulmonary embolism (HP:0002204)2.35544711
77Vertigo (HP:0002321)2.35141092
78Nuclear cataract (HP:0100018)2.34705756
79Mitral stenosis (HP:0001718)2.34333211
80Pulmonary infiltrates (HP:0002113)2.32188722
81Lower limb hyperreflexia (HP:0002395)2.31971940
82B lymphocytopenia (HP:0010976)2.31187240
83Interstitial pulmonary disease (HP:0006530)2.30894147
84Keratoconjunctivitis (HP:0001096)2.30222070
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30001598
86Anorexia (HP:0002039)2.29597443
87Abnormality of the pericardium (HP:0001697)2.27727896
88Colitis (HP:0002583)2.26257634
89Malnutrition (HP:0004395)2.25873507
90Axonal loss (HP:0003447)2.24912422
91Increased serum ferritin (HP:0003281)2.23821756
92Conjugated hyperbilirubinemia (HP:0002908)2.23034423
93Recurrent bronchitis (HP:0002837)2.22998758
94Arterial thrombosis (HP:0004420)2.21852442
95Nephritis (HP:0000123)2.20938711
96Neurofibrillary tangles (HP:0002185)2.20756547
97Pigmentary retinal degeneration (HP:0001146)2.18869659
98Recurrent lower respiratory tract infections (HP:0002783)2.17637799
99Autoimmune hemolytic anemia (HP:0001890)2.16956868
100Alveolar cell carcinoma (HP:0006519)2.16703508
101Peritonitis (HP:0002586)2.16594800
102Amaurosis fugax (HP:0100576)2.15748448
103Amyloidosis (HP:0011034)2.14039729
104Glomerulopathy (HP:0100820)2.13299733
105Memory impairment (HP:0002354)2.11046053
106Abnormality of complement system (HP:0005339)2.10939216
107Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10916991
108Acne (HP:0001061)2.10800879
109Increased IgE level (HP:0003212)2.10503925
110Keratoconjunctivitis sicca (HP:0001097)2.09352332
111IgA deficiency (HP:0002720)2.07965536
112Keratitis (HP:0000491)2.05912953
113Abnormality of the prostate (HP:0008775)2.05604039
114Congenital stationary night blindness (HP:0007642)2.04242326
115Porencephaly (HP:0002132)2.03993856
116Episodic fever (HP:0001954)2.03974845
117Cheilitis (HP:0100825)2.03916322
118Deep venous thrombosis (HP:0002625)2.03523089
119Purpura (HP:0000979)2.00226072
120Nasal polyposis (HP:0100582)1.99334088
121Abnormality of the nasal mucosa (HP:0000433)1.98612268
122Abnormality of glycolipid metabolism (HP:0010969)1.98047198
123Abnormality of liposaccharide metabolism (HP:0010968)1.98047198
124Abnormality of glycosphingolipid metabolism (HP:0004343)1.98047198
125Apathy (HP:0000741)1.96843546
126Meningitis (HP:0001287)1.96682056
127Pathologic fracture (HP:0002756)1.96437869
128Spastic tetraparesis (HP:0001285)1.95153565
129Gastrointestinal infarctions (HP:0005244)1.94403193
130Abnormal delayed hypersensitivity skin test (HP:0002963)1.93268127
131Bone pain (HP:0002653)1.92595483
132Chronic diarrhea (HP:0002028)1.92352607
133Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91633087
134Progressive visual loss (HP:0000529)1.91391232
135Abnormality of purine metabolism (HP:0004352)1.90459818
136Vascular calcification (HP:0004934)1.89923215
137Abnormality of the basal ganglia (HP:0002134)1.89082267
138Loss of speech (HP:0002371)1.87397706
139Spontaneous abortion (HP:0005268)1.85934815
140Leukocytosis (HP:0001974)1.85719981
141Abnormality of nucleobase metabolism (HP:0010932)1.85483827
142Hepatosplenomegaly (HP:0001433)1.85346937
143Hypobetalipoproteinemia (HP:0003563)1.84922845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.88502224
2MAP3K144.59370453
3TYK23.93490566
4IKBKE3.86700286
5TBK13.74906728
6IRAK43.05876304
7FGFR42.81584742
8IRAK32.68694723
9JAK12.47429820
10KIT2.42717062
11JAK32.35363963
12EPHA32.32732543
13DDR22.29686869
14PIM22.17857628
15RIPK42.14319882
16SIK32.11772591
17MAP3K132.08109017
18IKBKB2.02975449
19ERN11.80212147
20IRAK11.77635779
21TXK1.51988806
22CHUK1.49921974
23BLK1.48697381
24TAOK31.47874509
25BMPR21.47731771
26NME21.46118521
27FGFR31.45449848
28MOS1.42592027
29PRPF4B1.30446679
30CDC42BPA1.27793868
31EIF2AK21.25395043
32IRAK21.20824951
33EPHB11.16612380
34BMPR1B1.14819888
35SIK11.14520759
36MST41.06184629
37TGFBR21.03976835
38CSK1.02483584
39SYK1.00621509
40TAOK10.98953102
41MAP3K110.97467833
42MST1R0.95914036
43MAP3K50.94052462
44RIPK10.90449881
45MAP3K30.87284704
46JAK20.87202593
47MATK0.85418002
48NEK90.82542569
49CASK0.82507330
50LYN0.82375012
51PIK3CG0.80388552
52ADRBK20.80035159
53HIPK20.78761357
54TYRO30.78551502
55ABL20.77002599
56FGR0.74880714
57HCK0.74292792
58MAP4K10.72254967
59LCK0.71229903
60BCR0.69679141
61BMX0.69671677
62NUAK10.69250173
63MARK30.69229260
64ERBB40.66510881
65LATS20.66349834
66INSRR0.65938204
67MAP3K10.65503263
68STK100.64581570
69CSF1R0.64485900
70GRK70.62105237
71PKN10.61200076
72DYRK30.58643656
73MAPK110.58495684
74PRKCD0.58366793
75CDK60.56179001
76ZAP700.55823695
77PRKCQ0.55521027
78ERBB30.55352007
79LATS10.55188641
80STK40.51780240
81PDGFRA0.48839552
82ABL10.47419202
83ARAF0.47227573
84DAPK20.45408989
85PIM10.44476326
86YES10.43372270
87FES0.41834110
88MAPK40.41458213
89DYRK1B0.41226999
90MAPK70.40697279
91MAP2K30.40427815
92AKT30.39396526
93NLK0.38290562
94EGFR0.38200490
95BTK0.38182497
96PRKCE0.37694296
97TEC0.37682220
98TAOK20.37162298
99CDK40.35942125
100FRK0.33973689
101RPS6KA50.33605381
102SGK20.33241874
103ZAK0.32822446
104DAPK30.32777157
105STK30.25204737
106SGK10.25174740
107ITK0.24929351
108BCKDK0.24445618
109TNK20.23436614
110ACVR1B0.23351540
111SGK30.22467975
112STK240.21309657
113PRKAA20.20995413
114INSR0.19747029
115CAMK2G0.19519468
116FER0.19304247
117IGF1R0.19168833
118CLK10.19100225
119GRK10.18786459
120TESK20.16624424
121PDK10.15426132
122MAPK30.15125514
123PRKCZ0.15021061
124PDGFRB0.14901912
125KDR0.14807377
126TRPM70.14488152
127MAP2K60.12186076
128CAMKK20.11167303
129MAPKAPK20.10439274
130FYN0.10285393
131PDPK10.08523636
132TRIB30.07766364
133CDK140.06859450
134CDK150.05896892

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.60987387
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.05847395
3RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.89895490
4* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.81235830
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.63731365
6Leishmaniasis_Homo sapiens_hsa051402.49635932
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.33852984
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.31266478
9Allograft rejection_Homo sapiens_hsa053302.25594155
10Graft-versus-host disease_Homo sapiens_hsa053322.16873559
11Measles_Homo sapiens_hsa051622.02425825
12Influenza A_Homo sapiens_hsa051642.01370630
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99559279
14Arginine biosynthesis_Homo sapiens_hsa002201.99410291
15Complement and coagulation cascades_Homo sapiens_hsa046101.92102292
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.87687653
17Asthma_Homo sapiens_hsa053101.85242646
18Pertussis_Homo sapiens_hsa051331.71637758
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71008083
20Herpes simplex infection_Homo sapiens_hsa051681.64790827
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64037413
22Rheumatoid arthritis_Homo sapiens_hsa053231.63296601
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62648317
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62155255
25Malaria_Homo sapiens_hsa051441.59292736
26TNF signaling pathway_Homo sapiens_hsa046681.54616407
27Peroxisome_Homo sapiens_hsa041461.54026803
28African trypanosomiasis_Homo sapiens_hsa051431.53215929
29Autoimmune thyroid disease_Homo sapiens_hsa053201.52536779
30Histidine metabolism_Homo sapiens_hsa003401.51590525
31Legionellosis_Homo sapiens_hsa051341.50554430
32Tuberculosis_Homo sapiens_hsa051521.50477130
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46079471
34Osteoclast differentiation_Homo sapiens_hsa043801.39117289
35Hepatitis C_Homo sapiens_hsa051601.36486384
36Tryptophan metabolism_Homo sapiens_hsa003801.25801259
37* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25365600
38Toxoplasmosis_Homo sapiens_hsa051451.09900002
39Type I diabetes mellitus_Homo sapiens_hsa049401.08394315
40Caffeine metabolism_Homo sapiens_hsa002321.08145220
41Primary immunodeficiency_Homo sapiens_hsa053401.08053139
42Steroid biosynthesis_Homo sapiens_hsa001001.06345611
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.06174764
44Lysosome_Homo sapiens_hsa041421.06071872
45Phagosome_Homo sapiens_hsa041451.05081622
46Retinol metabolism_Homo sapiens_hsa008300.97709421
47Antigen processing and presentation_Homo sapiens_hsa046120.97243059
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.96871258
49Fatty acid degradation_Homo sapiens_hsa000710.96213560
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.92661479
51ABC transporters_Homo sapiens_hsa020100.91050604
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86699101
53Apoptosis_Homo sapiens_hsa042100.85040859
54* Chemokine signaling pathway_Homo sapiens_hsa040620.84953358
55Chemical carcinogenesis_Homo sapiens_hsa052040.82424019
56PPAR signaling pathway_Homo sapiens_hsa033200.81602055
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81126251
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79910369
59Salmonella infection_Homo sapiens_hsa051320.79437150
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79187192
61Vitamin digestion and absorption_Homo sapiens_hsa049770.77683019
62Folate biosynthesis_Homo sapiens_hsa007900.77251502
63Phenylalanine metabolism_Homo sapiens_hsa003600.77219564
64Mineral absorption_Homo sapiens_hsa049780.76324917
65Starch and sucrose metabolism_Homo sapiens_hsa005000.75563807
66beta-Alanine metabolism_Homo sapiens_hsa004100.75065228
67Hepatitis B_Homo sapiens_hsa051610.74949545
68Epstein-Barr virus infection_Homo sapiens_hsa051690.72620403
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69234481
70Acute myeloid leukemia_Homo sapiens_hsa052210.68016539
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67228054
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.66641530
73Arginine and proline metabolism_Homo sapiens_hsa003300.66038288
74T cell receptor signaling pathway_Homo sapiens_hsa046600.66000459
75Fatty acid biosynthesis_Homo sapiens_hsa000610.65722310
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63878199
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63299156
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62725714
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62673986
80Hematopoietic cell lineage_Homo sapiens_hsa046400.60149744
81Sulfur metabolism_Homo sapiens_hsa009200.58871030
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56597334
83Fatty acid metabolism_Homo sapiens_hsa012120.56402116
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55289438
85Bladder cancer_Homo sapiens_hsa052190.53489820
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51462726
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51283693
88Shigellosis_Homo sapiens_hsa051310.49877011
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48754650
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47399353
91Tyrosine metabolism_Homo sapiens_hsa003500.45953788
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45422977
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44998052
94B cell receptor signaling pathway_Homo sapiens_hsa046620.43992885
95Prion diseases_Homo sapiens_hsa050200.43307901
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.41400299
97Systemic lupus erythematosus_Homo sapiens_hsa053220.40933219
98Prolactin signaling pathway_Homo sapiens_hsa049170.39657843
99Sphingolipid metabolism_Homo sapiens_hsa006000.39178354
100Pancreatic cancer_Homo sapiens_hsa052120.38894335
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38185585
102HTLV-I infection_Homo sapiens_hsa051660.34090480
103Galactose metabolism_Homo sapiens_hsa000520.33385462
104Dorso-ventral axis formation_Homo sapiens_hsa043200.32226668
105VEGF signaling pathway_Homo sapiens_hsa043700.29626849
106Other glycan degradation_Homo sapiens_hsa005110.29113472
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28563638
108Viral carcinogenesis_Homo sapiens_hsa052030.28307364
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27795234
110Type II diabetes mellitus_Homo sapiens_hsa049300.26874003
111Amoebiasis_Homo sapiens_hsa051460.25587755
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.25519610
113Viral myocarditis_Homo sapiens_hsa054160.25145151
114Collecting duct acid secretion_Homo sapiens_hsa049660.24485602
115Arachidonic acid metabolism_Homo sapiens_hsa005900.24387397
116Fatty acid elongation_Homo sapiens_hsa000620.23359164
117Notch signaling pathway_Homo sapiens_hsa043300.23254428
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.23153528
119Selenocompound metabolism_Homo sapiens_hsa004500.21712356
120FoxO signaling pathway_Homo sapiens_hsa040680.20308791
121Bile secretion_Homo sapiens_hsa049760.20307000
122Insulin resistance_Homo sapiens_hsa049310.17018939
123HIF-1 signaling pathway_Homo sapiens_hsa040660.16965412
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.15425146
125Chronic myeloid leukemia_Homo sapiens_hsa052200.13174065
126Small cell lung cancer_Homo sapiens_hsa052220.12067643
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.06421400
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05376870
129Endocytosis_Homo sapiens_hsa041440.03810904
130MAPK signaling pathway_Homo sapiens_hsa040100.01429175
131Vibrio cholerae infection_Homo sapiens_hsa05110-0.0532112
132Renal cell carcinoma_Homo sapiens_hsa05211-0.0154100
133Platelet activation_Homo sapiens_hsa04611-0.0122052

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