CWC15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.86176747
2axon ensheathment in central nervous system (GO:0032291)5.64172230
3central nervous system myelination (GO:0022010)5.64172230
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.20860436
5viral transcription (GO:0019083)5.06353324
6protein neddylation (GO:0045116)5.03685780
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.97959497
8ATP synthesis coupled proton transport (GO:0015986)4.97959497
9translational termination (GO:0006415)4.94429102
10cotranslational protein targeting to membrane (GO:0006613)4.64940383
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.58166721
12protein targeting to ER (GO:0045047)4.57444610
13proteasome assembly (GO:0043248)4.38995061
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.38390118
15protein localization to endoplasmic reticulum (GO:0070972)4.36896838
16ribosomal small subunit assembly (GO:0000028)4.30993689
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.30652285
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.24753480
19ribosomal large subunit biogenesis (GO:0042273)4.12135079
20translational elongation (GO:0006414)4.07296256
21transcription elongation from RNA polymerase III promoter (GO:0006385)4.05397444
22termination of RNA polymerase III transcription (GO:0006386)4.05397444
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.02064960
24chaperone-mediated protein transport (GO:0072321)4.00297127
25cellular protein complex disassembly (GO:0043624)3.98901062
26translational initiation (GO:0006413)3.97819688
27maturation of SSU-rRNA (GO:0030490)3.96093145
28viral life cycle (GO:0019058)3.95810554
297-methylguanosine mRNA capping (GO:0006370)3.95606360
30RNA capping (GO:0036260)3.90543326
317-methylguanosine RNA capping (GO:0009452)3.90543326
32regulation of mitochondrial translation (GO:0070129)3.89928197
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88468427
34fatty acid elongation (GO:0030497)3.83200640
35protein-cofactor linkage (GO:0018065)3.75260099
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.73319350
37NADH dehydrogenase complex assembly (GO:0010257)3.73319350
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.73319350
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.73217419
40negative regulation of ligase activity (GO:0051352)3.73217419
41respiratory electron transport chain (GO:0022904)3.71789538
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.69172910
43translation (GO:0006412)3.68771197
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67444750
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.63629659
46electron transport chain (GO:0022900)3.61615584
47ATP biosynthetic process (GO:0006754)3.61017851
48inner mitochondrial membrane organization (GO:0007007)3.58625351
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.57333906
50hydrogen ion transmembrane transport (GO:1902600)3.56037445
51sequestering of actin monomers (GO:0042989)3.53122323
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52888373
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.49527249
54regulation of cellular amino acid metabolic process (GO:0006521)3.48487074
55respiratory chain complex IV assembly (GO:0008535)3.48249371
56cytochrome complex assembly (GO:0017004)3.46588899
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46511400
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45936357
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40348831
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40348831
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.40288912
62purine nucleoside triphosphate biosynthetic process (GO:0009145)3.39654301
63ribonucleoprotein complex biogenesis (GO:0022613)3.39514031
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.35221220
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34118915
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34118915
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34118915
68amino acid salvage (GO:0043102)3.32469428
69L-methionine salvage (GO:0071267)3.32469428
70L-methionine biosynthetic process (GO:0071265)3.32469428
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31234406
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31234406
73long-chain fatty acid biosynthetic process (GO:0042759)3.27759940
74signal transduction involved in DNA damage checkpoint (GO:0072422)3.27441463
75signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27441463
76protein complex disassembly (GO:0043241)3.25859899
77DNA damage response, detection of DNA damage (GO:0042769)3.22783721
78transcription elongation from RNA polymerase I promoter (GO:0006362)3.22580571
79proton transport (GO:0015992)3.22543904
80signal transduction involved in cell cycle checkpoint (GO:0072395)3.21545197
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19571820
82protein targeting to mitochondrion (GO:0006626)3.19129583
83chromatin remodeling at centromere (GO:0031055)3.18617042
84protein complex biogenesis (GO:0070271)3.17418040
85nuclear-transcribed mRNA catabolic process (GO:0000956)3.17135911
86neutrophil activation involved in immune response (GO:0002283)3.16160251
87hydrogen transport (GO:0006818)3.15938265
88transcription from RNA polymerase I promoter (GO:0006360)3.14302621
89intracellular protein transmembrane import (GO:0044743)3.13375705
90positive regulation of ligase activity (GO:0051351)3.12977087
91behavioral response to nicotine (GO:0035095)3.12489292
92cellular component biogenesis (GO:0044085)3.11392201
93rRNA modification (GO:0000154)3.09989889
94cullin deneddylation (GO:0010388)3.08912083
95macromolecular complex disassembly (GO:0032984)3.08208979
96establishment of protein localization to mitochondrion (GO:0072655)3.07633189
97transcription elongation from RNA polymerase II promoter (GO:0006368)3.06982511
98protein targeting to membrane (GO:0006612)3.05826711
99CENP-A containing nucleosome assembly (GO:0034080)3.05662678
100GTP biosynthetic process (GO:0006183)3.01871562
101termination of RNA polymerase I transcription (GO:0006363)3.01783351
102formation of translation preinitiation complex (GO:0001731)3.01094949
103cholesterol biosynthetic process (GO:0006695)3.00175470
104mRNA catabolic process (GO:0006402)2.98235973
105rRNA processing (GO:0006364)2.96905106
106protein deneddylation (GO:0000338)2.96463430
107ribonucleoside triphosphate biosynthetic process (GO:0009201)2.94150161
108ensheathment of neurons (GO:0007272)2.92721307
109axon ensheathment (GO:0008366)2.92721307
110epithelial cilium movement (GO:0003351)2.92164248
111regulation of ubiquitin-protein transferase activity (GO:0051438)2.91647088
112establishment of integrated proviral latency (GO:0075713)2.90592403
113protein localization to mitochondrion (GO:0070585)2.90308918
114positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.89539484
115mitochondrial respiratory chain complex assembly (GO:0033108)2.88963343
116myelination (GO:0042552)2.88179907
117regulation of ligase activity (GO:0051340)2.87364990
118spliceosomal snRNP assembly (GO:0000387)2.84935804
119transcription-coupled nucleotide-excision repair (GO:0006283)2.82100558
120establishment of viral latency (GO:0019043)2.81834228
121rRNA metabolic process (GO:0016072)2.81656778
122mitochondrial transport (GO:0006839)2.79962671
123transcription initiation from RNA polymerase I promoter (GO:0006361)2.79565566
124positive regulation of viral transcription (GO:0050434)2.78696407
125regulation of cilium movement (GO:0003352)2.78480587
126DNA-templated transcription, elongation (GO:0006354)2.77998874
127microtubule polymerization or depolymerization (GO:0031109)2.77591165
128spliceosomal complex assembly (GO:0000245)2.75933042
129pseudouridine synthesis (GO:0001522)2.75722134
130histone exchange (GO:0043486)2.75287995
131nucleoside triphosphate biosynthetic process (GO:0009142)2.74966686
132water-soluble vitamin biosynthetic process (GO:0042364)2.73913423
133organelle disassembly (GO:1903008)2.71888338
134RNA catabolic process (GO:0006401)2.71159124
135oxidative phosphorylation (GO:0006119)2.69742970
136pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68937341
137nonmotile primary cilium assembly (GO:0035058)2.67251359
138platelet dense granule organization (GO:0060155)2.67173322
139DNA double-strand break processing (GO:0000729)2.64813025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.02427591
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.07108067
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.77473404
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.62486678
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.21955617
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.80022650
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.78110577
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.65228530
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.50895029
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.45241081
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.40327407
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08117034
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89957529
14VDR_23849224_ChIP-Seq_CD4+_Human2.66032128
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63012934
16ELK1_19687146_ChIP-ChIP_HELA_Human2.59455354
17E2F7_22180533_ChIP-Seq_HELA_Human2.57883180
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52003531
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37839759
20EZH2_22144423_ChIP-Seq_EOC_Human2.31933603
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31667168
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31087738
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30972713
24DCP1A_22483619_ChIP-Seq_HELA_Human2.28455065
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.23227035
26ZNF274_21170338_ChIP-Seq_K562_Hela2.22132002
27XRN2_22483619_ChIP-Seq_HELA_Human2.21694485
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05288306
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04354111
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04055129
31FOXP3_21729870_ChIP-Seq_TREG_Human2.01383486
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.91451644
33FUS_26573619_Chip-Seq_HEK293_Human1.90950834
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89928352
35EWS_26573619_Chip-Seq_HEK293_Human1.87647950
36IGF1R_20145208_ChIP-Seq_DFB_Human1.82880582
37TTF2_22483619_ChIP-Seq_HELA_Human1.80319984
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79825935
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73702085
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.68860564
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66573726
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.66467982
43* GABP_19822575_ChIP-Seq_HepG2_Human1.66102932
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65033549
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59309762
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57160100
47AR_21909140_ChIP-Seq_LNCAP_Human1.56128846
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54084137
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53650801
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52797366
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.49969106
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.49001467
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47949802
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42437444
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.40586785
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39389207
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38238077
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35383696
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33901221
60* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30458148
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28399107
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27499443
63* P300_19829295_ChIP-Seq_ESCs_Human1.26608196
64MYC_18940864_ChIP-ChIP_HL60_Human1.24005362
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24005205
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21587130
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20611397
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20584632
69SOX17_20123909_ChIP-Seq_XEN_Mouse1.19809009
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18408062
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18307943
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.17832421
73TP53_22573176_ChIP-Seq_HFKS_Human1.17507849
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16347636
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14450728
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13677331
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11871287
78* SPI1_23547873_ChIP-Seq_NB4_Human1.11623970
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11447827
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11235050
81* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10798529
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07195825
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05455571
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.05384317
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04581099
86TAF15_26573619_Chip-Seq_HEK293_Human1.03756961
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03066840
88KDM5A_27292631_Chip-Seq_BREAST_Human1.02431057
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99778322
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99456789
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98805304
92TFEB_21752829_ChIP-Seq_HELA_Human0.98523866
93RNF2_27304074_Chip-Seq_NSC_Mouse0.96481120
94IRF1_19129219_ChIP-ChIP_H3396_Human0.96353237
95HTT_18923047_ChIP-ChIP_STHdh_Human0.94224816
96CBP_20019798_ChIP-Seq_JUKART_Human0.93795719
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93795719
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92659639
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92372291
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.91880344
101GBX2_23144817_ChIP-Seq_PC3_Human0.90852498
102NANOG_19829295_ChIP-Seq_ESCs_Human0.90576601
103SOX2_19829295_ChIP-Seq_ESCs_Human0.90576601
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89908783
105ER_23166858_ChIP-Seq_MCF-7_Human0.89622031
106ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89241902
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88370725
108FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87714547
109FOXA1_25329375_ChIP-Seq_VCAP_Human0.87714547
110VDR_22108803_ChIP-Seq_LS180_Human0.86973332
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86810374
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.86417941
113NCOR_22424771_ChIP-Seq_293T_Human0.85792695
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85527886
115ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85130429
116CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84878595
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.84520623
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83843362
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83759797
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83025510
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82480479
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81066819
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78894770
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78648348
125STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78401811
126* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76524168
127NANOG_18692474_ChIP-Seq_MEFs_Mouse0.75665881
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74094729
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73102848
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73049440
131TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.72307726
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.71933375
133* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71721195
134ELF5_23300383_ChIP-Seq_T47D_Human0.71067934
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69814739
136SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68829105
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67660114
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.66800506
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.66800506
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.66800506
141STAT1_20625510_ChIP-Seq_HELA_Human0.66072879
142ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.66039732
143KLF4_18555785_ChIP-Seq_MESCs_Mouse0.65322756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.44809201
2MP0003136_yellow_coat_color3.25212753
3MP0003806_abnormal_nucleotide_metabolis3.14993381
4MP0001529_abnormal_vocalization3.05866369
5MP0003693_abnormal_embryo_hatching3.04319565
6MP0002837_dystrophic_cardiac_calcinosis3.03591660
7MP0004957_abnormal_blastocyst_morpholog2.79658101
8MP0003186_abnormal_redox_activity2.69769463
9MP0005451_abnormal_body_composition2.69560417
10MP0008932_abnormal_embryonic_tissue2.52575982
11MP0008260_abnormal_autophagy2.51186499
12MP0005408_hypopigmentation2.42406620
13MP0003718_maternal_effect2.36838604
14MP0008057_abnormal_DNA_replication2.33608471
15MP0001905_abnormal_dopamine_level2.29881718
16MP0008789_abnormal_olfactory_epithelium2.28186918
17MP0009379_abnormal_foot_pigmentation2.24830744
18MP0009333_abnormal_splenocyte_physiolog2.21644446
19MP0006082_CNS_inflammation2.19591873
20MP0003950_abnormal_plasma_membrane2.18113014
21MP0006072_abnormal_retinal_apoptosis2.15031495
22MP0001984_abnormal_olfaction2.06909042
23MP0003077_abnormal_cell_cycle2.03341296
24MP0000372_irregular_coat_pigmentation2.03145078
25MP0002148_abnormal_hypersensitivity_rea1.93635872
26MP0003787_abnormal_imprinting1.92528864
27MP0003121_genomic_imprinting1.91739546
28MP0010094_abnormal_chromosome_stability1.90632996
29MP0002653_abnormal_ependyma_morphology1.89058805
30MP0009785_altered_susceptibility_to1.84893912
31MP0005394_taste/olfaction_phenotype1.84875639
32MP0005499_abnormal_olfactory_system1.84875639
33MP0005000_abnormal_immune_tolerance1.83354572
34MP0006276_abnormal_autonomic_nervous1.78429956
35MP0001293_anophthalmia1.77528514
36MP0005671_abnormal_response_to1.76535613
37MP0003646_muscle_fatigue1.70945085
38MP0003315_abnormal_perineum_morphology1.63525940
39MP0002163_abnormal_gland_morphology1.63191237
40MP0002102_abnormal_ear_morphology1.62298352
41MP0005058_abnormal_lysosome_morphology1.61378662
42MP0003111_abnormal_nucleus_morphology1.61354407
43MP0005084_abnormal_gallbladder_morpholo1.61036425
44MP0003123_paternal_imprinting1.60872482
45MP0008058_abnormal_DNA_repair1.60017140
46MP0005171_absent_coat_pigmentation1.58865465
47MP0001835_abnormal_antigen_presentation1.58574111
48MP0003724_increased_susceptibility_to1.56457783
49MP0001542_abnormal_bone_strength1.55209654
50MP0003122_maternal_imprinting1.55011788
51MP0001727_abnormal_embryo_implantation1.53009982
52MP0008995_early_reproductive_senescence1.48064766
53MP0004381_abnormal_hair_follicle1.44611401
54MP0002132_abnormal_respiratory_system1.41574637
55MP0003011_delayed_dark_adaptation1.41389944
56MP0001968_abnormal_touch/_nociception1.38483962
57MP0002736_abnormal_nociception_after1.38404610
58MP0004145_abnormal_muscle_electrophysio1.37032407
59MP0000631_abnormal_neuroendocrine_gland1.36095343
60MP0005410_abnormal_fertilization1.35196112
61MP0005025_abnormal_response_to1.34800518
62MP0002272_abnormal_nervous_system1.34684637
63MP0009046_muscle_twitch1.32668201
64MP0005551_abnormal_eye_electrophysiolog1.30818213
65MP0005646_abnormal_pituitary_gland1.30652122
66MP0006036_abnormal_mitochondrial_physio1.29386627
67MP0002419_abnormal_innate_immunity1.28950177
68MP0005253_abnormal_eye_physiology1.28800299
69MP0003221_abnormal_cardiomyocyte_apopto1.28534635
70MP0004742_abnormal_vestibular_system1.27941757
71MP0002277_abnormal_respiratory_mucosa1.27753392
72MP0003656_abnormal_erythrocyte_physiolo1.24578903
73MP0002723_abnormal_immune_serum1.24487432
74MP0003436_decreased_susceptibility_to1.21517656
75MP0005389_reproductive_system_phenotype1.21273190
76MP0003690_abnormal_glial_cell1.19768821
77MP0001730_embryonic_growth_arrest1.19249959
78MP0004142_abnormal_muscle_tone1.19200942
79MP0008877_abnormal_DNA_methylation1.19005554
80MP0010030_abnormal_orbit_morphology1.17119880
81MP0002452_abnormal_antigen_presenting1.16699727
82MP0001188_hyperpigmentation1.16439348
83MP0006035_abnormal_mitochondrial_morpho1.15755586
84MP0000778_abnormal_nervous_system1.14840272
85MP0001346_abnormal_lacrimal_gland1.14809732
86MP0000049_abnormal_middle_ear1.13865788
87MP0001485_abnormal_pinna_reflex1.11449084
88MP0003786_premature_aging1.10145550
89MP0008007_abnormal_cellular_replicative1.09774970
90MP0004147_increased_porphyrin_level1.08285813
91MP0002420_abnormal_adaptive_immunity1.08104698
92MP0003890_abnormal_embryonic-extraembry1.07988665
93MP0009745_abnormal_behavioral_response1.07726729
94MP0005423_abnormal_somatic_nervous1.07616878
95MP0001819_abnormal_immune_cell1.06605741
96MP0001800_abnormal_humoral_immune1.04935883
97MP0002557_abnormal_social/conspecific_i1.01979224
98MP0000343_altered_response_to1.00675952
99MP0005164_abnormal_response_to1.00010973
100MP0002933_joint_inflammation0.99316392
101MP0003937_abnormal_limbs/digits/tail_de0.98484396
102MP0004133_heterotaxia0.97811447
103MP0005645_abnormal_hypothalamus_physiol0.97012414
104MP0003698_abnormal_male_reproductive0.96227949
105MP0000685_abnormal_immune_system0.95652992
106MP0002234_abnormal_pharynx_morphology0.94672265
107MP0002938_white_spotting0.94533441
108MP0008872_abnormal_physiological_respon0.94080386
109MP0002752_abnormal_somatic_nervous0.94034207
110MP0000653_abnormal_sex_gland0.92757208
111MP0004885_abnormal_endolymph0.92526403
112MP0001851_eye_inflammation0.91930568
113MP0004215_abnormal_myocardial_fiber0.90958683
114MP0001919_abnormal_reproductive_system0.90324057
115MP0002233_abnormal_nose_morphology0.89831910
116MP0000026_abnormal_inner_ear0.89821804
117MP0001486_abnormal_startle_reflex0.89707288
118MP0002184_abnormal_innervation0.88613636
119MP0001661_extended_life_span0.88175022
120MP0000716_abnormal_immune_system0.87488614
121MP0003938_abnormal_ear_development0.87350288
122MP0005195_abnormal_posterior_eye0.87277124
123MP0005391_vision/eye_phenotype0.87071470
124MP0002751_abnormal_autonomic_nervous0.86682180
125MP0003634_abnormal_glial_cell0.85169727
126MP0001533_abnormal_skeleton_physiology0.84954751
127MP0002095_abnormal_skin_pigmentation0.84779540
128MP0002572_abnormal_emotion/affect_behav0.84750090
129MP0001286_abnormal_eye_development0.84038145
130MP0009697_abnormal_copulation0.83989770
131MP0000383_abnormal_hair_follicle0.83273033
132MP0005387_immune_system_phenotype0.83072171
133MP0001790_abnormal_immune_system0.83072171
134MP0002282_abnormal_trachea_morphology0.81893626
135MP0003567_abnormal_fetal_cardiomyocyte0.81268627
136MP0002405_respiratory_system_inflammati0.80546841
137MP0003195_calcinosis0.80133532
138MP0002210_abnormal_sex_determination0.80081991
139MP0002067_abnormal_sensory_capabilities0.79223531
140MP0008875_abnormal_xenobiotic_pharmacok0.78946212
141MP0002734_abnormal_mechanical_nocicepti0.77953595
142MP0003448_altered_tumor_morphology0.77635473
143MP0000350_abnormal_cell_proliferation0.77392874
144MP0001970_abnormal_pain_threshold0.77068828
145MP0005379_endocrine/exocrine_gland_phen0.76249035
146MP0002429_abnormal_blood_cell0.75366914
147MP0001145_abnormal_male_reproductive0.74316447
148MP0009840_abnormal_foam_cell0.72063569
149MP0002160_abnormal_reproductive_system0.71108268
150MP0000750_abnormal_muscle_regeneration0.70581770
151MP0001986_abnormal_taste_sensitivity0.69873637
152MP0002398_abnormal_bone_marrow0.69768249
153MP0003880_abnormal_central_pattern0.69177625
154MP0002638_abnormal_pupillary_reflex0.68999337
155MP0001929_abnormal_gametogenesis0.68991895
156MP0000313_abnormal_cell_death0.68747827
157MP0000465_gastrointestinal_hemorrhage0.67966974
158MP0000689_abnormal_spleen_morphology0.67838821
159MP0006292_abnormal_olfactory_placode0.66914065
160MP0005310_abnormal_salivary_gland0.66307187
161MP0001845_abnormal_inflammatory_respons0.64364569
162MP0002722_abnormal_immune_system0.64262319
163MP0009250_abnormal_appendicular_skeleto0.63467307

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)5.18311327
2Increased serum pyruvate (HP:0003542)5.18311327
3Acute necrotizing encephalopathy (HP:0006965)4.91562249
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.72129604
5Abnormality of cells of the erythroid lineage (HP:0012130)4.47053616
6Parakeratosis (HP:0001036)4.46163906
7Cerebral hypomyelination (HP:0006808)4.27123309
8Abnormal mitochondria in muscle tissue (HP:0008316)4.21397396
9Mitochondrial inheritance (HP:0001427)4.17132436
10Abnormal number of erythroid precursors (HP:0012131)3.96579522
11Progressive macrocephaly (HP:0004481)3.95466419
12Acute encephalopathy (HP:0006846)3.92822154
13Increased hepatocellular lipid droplets (HP:0006565)3.64974645
143-Methylglutaconic aciduria (HP:0003535)3.57619903
15Hepatocellular necrosis (HP:0001404)3.57157898
16Increased CSF lactate (HP:0002490)3.57043525
17Renal Fanconi syndrome (HP:0001994)3.44655710
18Reticulocytopenia (HP:0001896)3.42525636
19Congenital ichthyosiform erythroderma (HP:0007431)3.37704786
20Macrocytic anemia (HP:0001972)3.30294095
21Leukodystrophy (HP:0002415)3.25510155
22Pancreatic fibrosis (HP:0100732)3.16619952
23Lipid accumulation in hepatocytes (HP:0006561)3.12207825
24Pancreatic cysts (HP:0001737)3.11257531
25Sensory axonal neuropathy (HP:0003390)3.10587448
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.99912136
27True hermaphroditism (HP:0010459)2.95164940
28Abnormality of midbrain morphology (HP:0002418)2.88289844
29Molar tooth sign on MRI (HP:0002419)2.88289844
30Respiratory failure (HP:0002878)2.88205929
31Exertional dyspnea (HP:0002875)2.88038344
32Hepatic necrosis (HP:0002605)2.85869965
33Hepatosplenomegaly (HP:0001433)2.82302617
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79449404
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79449404
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77868113
37Medial flaring of the eyebrow (HP:0010747)2.70998757
38Stenosis of the external auditory canal (HP:0000402)2.68802974
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.59005494
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59005494
41Cerebral edema (HP:0002181)2.57228033
42Pallor (HP:0000980)2.55564058
43Nephronophthisis (HP:0000090)2.55364699
44Congenital, generalized hypertrichosis (HP:0004540)2.53033206
45Hyperglycinemia (HP:0002154)2.51576374
46Methylmalonic acidemia (HP:0002912)2.51211632
47Abnormality of the labia minora (HP:0012880)2.48941729
48Birth length less than 3rd percentile (HP:0003561)2.48472922
49Breast hypoplasia (HP:0003187)2.42657805
50Exercise intolerance (HP:0003546)2.35339788
51Sclerocornea (HP:0000647)2.35236541
52Increased serum lactate (HP:0002151)2.35007021
53CNS hypomyelination (HP:0003429)2.34504582
54Abnormality of urine glucose concentration (HP:0011016)2.32362364
55Glycosuria (HP:0003076)2.32362364
56Abnormality of renal resorption (HP:0011038)2.30085358
57Optic disc pallor (HP:0000543)2.29113914
58Abnormal hemoglobin (HP:0011902)2.28412168
59Peripheral hypomyelination (HP:0007182)2.27019355
60Myokymia (HP:0002411)2.25775791
61Increased intramyocellular lipid droplets (HP:0012240)2.25215495
62Carpal bone hypoplasia (HP:0001498)2.24770451
63Respiratory difficulties (HP:0002880)2.24727796
64Rough bone trabeculation (HP:0100670)2.23763604
65Gait imbalance (HP:0002141)2.21373025
66Amniotic constriction ring (HP:0009775)2.18534822
67Abnormality of placental membranes (HP:0011409)2.18534822
68Methylmalonic aciduria (HP:0012120)2.18498165
69Congenital primary aphakia (HP:0007707)2.17733750
70Septo-optic dysplasia (HP:0100842)2.17601039
71Irregular epiphyses (HP:0010582)2.16585166
72Spastic paraparesis (HP:0002313)2.15797611
73Adrenal hypoplasia (HP:0000835)2.14220848
74Abnormality of the umbilical cord (HP:0010881)2.11384276
75Lethargy (HP:0001254)2.11304840
76Secondary amenorrhea (HP:0000869)2.10418148
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10361272
78Absent septum pellucidum (HP:0001331)2.09583800
79Abnormal umbilical cord blood vessels (HP:0011403)2.08274356
80Single umbilical artery (HP:0001195)2.08274356
81Abnormality of the fetal cardiovascular system (HP:0010948)2.08274356
82Nephrogenic diabetes insipidus (HP:0009806)2.07036601
83Abnormality of the septum pellucidum (HP:0007375)2.05930023
84Postnatal microcephaly (HP:0005484)2.05718851
85Prolonged neonatal jaundice (HP:0006579)2.04109160
86Lactic acidosis (HP:0003128)2.02901871
87Metaphyseal dysplasia (HP:0100255)2.01250891
88Male pseudohermaphroditism (HP:0000037)2.01188218
89Abnormality of macrophages (HP:0004311)2.00523860
90Erythroderma (HP:0001019)2.00052962
91Segmental peripheral demyelination/remyelination (HP:0003481)1.98930323
92Colon cancer (HP:0003003)1.98619603
93Abnormality of the renal medulla (HP:0100957)1.98531943
94Reduced antithrombin III activity (HP:0001976)1.96031128
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95366681
96Anencephaly (HP:0002323)1.95105188
97Hypoplastic pelvis (HP:0008839)1.94534304
98Absent thumb (HP:0009777)1.93142521
99Aplastic anemia (HP:0001915)1.91915587
100Hyperphosphaturia (HP:0003109)1.91808108
101Absent epiphyses (HP:0010577)1.91528334
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91528334
103Recurrent abscess formation (HP:0002722)1.90898653
104Small epiphyses (HP:0010585)1.90467424
105Type II lissencephaly (HP:0007260)1.90376369
106Abnormal respiratory motile cilium physiology (HP:0012261)1.88425411
107Abnormal trabecular bone morphology (HP:0100671)1.86610459
108Abnormalities of placenta or umbilical cord (HP:0001194)1.84094403
109Muscle fiber splitting (HP:0003555)1.82062744
110CNS demyelination (HP:0007305)1.82054493
111Multiple enchondromatosis (HP:0005701)1.81627542
112Anophthalmia (HP:0000528)1.81382683
113Autoamputation (HP:0001218)1.80669776
114Abnormality of alanine metabolism (HP:0010916)1.79753588
115Hyperalaninemia (HP:0003348)1.79753588
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79753588
117Neurofibrillary tangles (HP:0002185)1.79316870
118Genital tract atresia (HP:0001827)1.79211273
119Vaginal atresia (HP:0000148)1.78237467
120Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78128805
121Conical tooth (HP:0000698)1.77660764
122Abnormal ciliary motility (HP:0012262)1.76738239
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.76320395
124Increased muscle lipid content (HP:0009058)1.76163749
125Optic nerve hypoplasia (HP:0000609)1.75994837
126Asplenia (HP:0001746)1.73327190
127Retinal dysplasia (HP:0007973)1.73199814
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72719815
129X-linked dominant inheritance (HP:0001423)1.72461235
130Aplasia/hypoplasia of the uterus (HP:0008684)1.72038582
131Meckel diverticulum (HP:0002245)1.71409862
132Generalized aminoaciduria (HP:0002909)1.71266004
133Abnormality of the ileum (HP:0001549)1.69749572
134Abnormal respiratory epithelium morphology (HP:0012253)1.68781879
135Abnormal respiratory motile cilium morphology (HP:0005938)1.68781879
136Emotional lability (HP:0000712)1.68598246
137Nemaline bodies (HP:0003798)1.68374198
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.68303710
139Paralysis (HP:0003470)1.67761616
140Median cleft lip (HP:0000161)1.67523382
141Cleft eyelid (HP:0000625)1.67295305
142Poor head control (HP:0002421)1.66843360
143Recurrent bacterial skin infections (HP:0005406)1.66831919
144Hypoplasia of the uterus (HP:0000013)1.65549190
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64676423
146Abnormal rod and cone electroretinograms (HP:0008323)1.64436712
147Delusions (HP:0000746)1.64418138
148Cystic liver disease (HP:0006706)1.64082954
149Type I transferrin isoform profile (HP:0003642)1.63706348
150Pendular nystagmus (HP:0012043)1.62582228
151Abnormal protein glycosylation (HP:0012346)1.62102406
152Abnormal glycosylation (HP:0012345)1.62102406
153Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62102406
154Abnormal protein N-linked glycosylation (HP:0012347)1.62102406
155Pancytopenia (HP:0001876)1.61883147
156Obstructive lung disease (HP:0006536)1.61651979
157Chronic obstructive pulmonary disease (HP:0006510)1.61651979
158Cerebral hemorrhage (HP:0001342)1.61116420
159Vacuolated lymphocytes (HP:0001922)1.59220591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.37159804
2STK393.66307332
3NME23.43305364
4BUB13.37313006
5VRK23.31589430
6LIMK12.91561054
7BCR2.87312591
8MST42.86315583
9TESK22.82098674
10PINK12.80609034
11EIF2AK12.57575891
12ZAK2.51367810
13OXSR12.30225939
14PIM22.10152374
15WEE12.04223254
16STK162.02538337
17ARAF1.95300468
18NUAK11.93214298
19EIF2AK31.88132374
20BCKDK1.82586453
21MAP2K71.81183839
22TLK11.76164926
23WNK31.70096683
24MAP4K21.68860599
25NME11.68641620
26CASK1.64976121
27VRK11.56647684
28DYRK21.46262317
29CSNK1G31.43424928
30MAP3K41.41140738
31CDK191.38860652
32SRPK11.35920251
33MET1.34060165
34BLK1.33923992
35FRK1.33894357
36MKNK11.33691208
37TNIK1.28511570
38PLK41.26670893
39MAPKAPK51.25145926
40NEK11.24644508
41WNK41.24365536
42TESK11.20154908
43PKN11.16718190
44GRK11.13973251
45EPHB11.13228540
46CSNK1G11.12589567
47BMPR1B1.12481925
48DYRK31.11638489
49PNCK1.08119832
50TRIM281.06875786
51RPS6KA51.05754638
52ABL21.03182146
53TSSK61.02397206
54CDC71.01552337
55PLK21.00990900
56CSNK1A1L1.00978196
57MAPK131.00646146
58BRSK20.98464937
59PAK10.95805342
60MARK10.95410671
61MAP3K120.94762598
62BRAF0.94116111
63IRAK40.91700038
64AURKA0.90919305
65TGFBR10.88953994
66PRKCG0.87775875
67FGR0.86627382
68PDK20.84698693
69MINK10.83389750
70STK100.82564600
71ILK0.82239166
72EPHB20.82046822
73CDK30.81226611
74ACVR1B0.80266640
75EIF2AK20.79946197
76MUSK0.79523313
77PLK10.79495186
78CLK10.79361414
79PLK30.79263617
80TXK0.78801353
81STK40.78737176
82GRK70.77925559
83IKBKB0.76425027
84TAF10.76083286
85MKNK20.76047902
86PHKG10.74265858
87PHKG20.74265858
88RPS6KA40.72809650
89AURKB0.72365506
90ROCK20.70734637
91ERBB40.70658103
92CAMK2B0.69938015
93MARK30.68697268
94KDR0.68139591
95EPHA40.64387784
96MAP3K140.64281191
97STK38L0.64186257
98CSNK1G20.63899088
99CCNB10.63790348
100MAPK150.62624048
101IRAK20.62230290
102LRRK20.61253726
103MOS0.58502815
104CDK140.58424793
105CSNK2A10.58163045
106PASK0.56775841
107CSNK2A20.55840838
108CHEK20.55831091
109TEC0.54955851
110INSRR0.53938939
111UHMK10.53858452
112ATR0.53426804
113TBK10.50222758
114NEK20.49189214
115CAMK2G0.48933353
116CSNK1A10.48265397
117BMPR20.48053414
118MYLK0.47780788
119CDK70.47672229
120TIE10.47426667
121CAMK2D0.47410000
122PIM10.46715135
123CSNK1E0.46577962
124CDK80.46156859
125MAP3K80.45600612
126MAP4K10.45270841
127ERBB30.44299680
128PAK30.44133793
129OBSCN0.44031914
130PRKACA0.43251895
131PIK3CA0.42678780
132ATM0.42667125
133PRKCQ0.42596167
134MELK0.42321429
135PRKCE0.41884145
136CDK180.41772494
137CDK150.41491648
138CDK11A0.41010629
139ADRBK20.40613792
140MAP2K20.39978442
141DAPK30.39890512
142FGFR20.39361494
143LYN0.38486667
144IRAK10.36315973
145MAPKAPK20.35627732
146TTK0.35357229
147TRPM70.35075063
148LCK0.34994640

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.50360813
2Proteasome_Homo sapiens_hsa030504.42159619
3RNA polymerase_Homo sapiens_hsa030203.65428332
4Oxidative phosphorylation_Homo sapiens_hsa001903.64367661
5Protein export_Homo sapiens_hsa030603.21165154
6Parkinsons disease_Homo sapiens_hsa050123.05047291
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.01702135
8Huntingtons disease_Homo sapiens_hsa050162.31235670
9Basal transcription factors_Homo sapiens_hsa030222.26265869
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17310576
11Alzheimers disease_Homo sapiens_hsa050102.14433899
12* Spliceosome_Homo sapiens_hsa030402.11662910
13Steroid biosynthesis_Homo sapiens_hsa001002.00449349
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92404863
15DNA replication_Homo sapiens_hsa030301.92257567
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82802689
17Nucleotide excision repair_Homo sapiens_hsa034201.80911527
18Pyrimidine metabolism_Homo sapiens_hsa002401.79917984
19Homologous recombination_Homo sapiens_hsa034401.74571326
20Mismatch repair_Homo sapiens_hsa034301.68266421
21Vitamin B6 metabolism_Homo sapiens_hsa007501.67079021
22Fatty acid elongation_Homo sapiens_hsa000621.65679960
23RNA transport_Homo sapiens_hsa030131.54500270
24Ether lipid metabolism_Homo sapiens_hsa005651.52164260
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51810557
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43209913
27Propanoate metabolism_Homo sapiens_hsa006401.38021004
28Glutathione metabolism_Homo sapiens_hsa004801.22396958
29Non-homologous end-joining_Homo sapiens_hsa034501.21500950
30Graft-versus-host disease_Homo sapiens_hsa053321.18892843
31Rheumatoid arthritis_Homo sapiens_hsa053231.17995222
32Phototransduction_Homo sapiens_hsa047441.16920681
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12899798
34Base excision repair_Homo sapiens_hsa034101.12780625
35Cell cycle_Homo sapiens_hsa041101.12416314
36Linoleic acid metabolism_Homo sapiens_hsa005911.10644284
37Purine metabolism_Homo sapiens_hsa002301.07589151
38Butanoate metabolism_Homo sapiens_hsa006501.07473388
39Pyruvate metabolism_Homo sapiens_hsa006201.05873640
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02762904
41Allograft rejection_Homo sapiens_hsa053300.99817772
42RNA degradation_Homo sapiens_hsa030180.98625403
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95957509
44Autoimmune thyroid disease_Homo sapiens_hsa053200.95912942
45Arachidonic acid metabolism_Homo sapiens_hsa005900.94758426
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93764636
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93503102
48Asthma_Homo sapiens_hsa053100.88722735
49Peroxisome_Homo sapiens_hsa041460.88657450
50Epstein-Barr virus infection_Homo sapiens_hsa051690.88034978
51Nitrogen metabolism_Homo sapiens_hsa009100.86576448
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.85664485
53Folate biosynthesis_Homo sapiens_hsa007900.85658046
54Sulfur metabolism_Homo sapiens_hsa009200.83376544
55Malaria_Homo sapiens_hsa051440.82045812
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81106107
57Nicotine addiction_Homo sapiens_hsa050330.79289751
58Fanconi anemia pathway_Homo sapiens_hsa034600.78543845
59Systemic lupus erythematosus_Homo sapiens_hsa053220.78465508
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75796296
61Cardiac muscle contraction_Homo sapiens_hsa042600.75036713
62Phagosome_Homo sapiens_hsa041450.74808876
63Regulation of autophagy_Homo sapiens_hsa041400.73953922
64Pentose phosphate pathway_Homo sapiens_hsa000300.73699285
65Selenocompound metabolism_Homo sapiens_hsa004500.73655779
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72773117
67Collecting duct acid secretion_Homo sapiens_hsa049660.72493746
68Sphingolipid metabolism_Homo sapiens_hsa006000.71438464
69Olfactory transduction_Homo sapiens_hsa047400.70465245
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.66289860
71Tryptophan metabolism_Homo sapiens_hsa003800.64154070
72p53 signaling pathway_Homo sapiens_hsa041150.64077716
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62583034
74Legionellosis_Homo sapiens_hsa051340.62076462
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61747437
76Metabolic pathways_Homo sapiens_hsa011000.61338783
77Arginine and proline metabolism_Homo sapiens_hsa003300.60215069
78Histidine metabolism_Homo sapiens_hsa003400.56233559
79Sulfur relay system_Homo sapiens_hsa041220.54449524
80Shigellosis_Homo sapiens_hsa051310.52537376
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52434626
82Vibrio cholerae infection_Homo sapiens_hsa051100.51881912
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51607645
84Hedgehog signaling pathway_Homo sapiens_hsa043400.50406684
85Primary immunodeficiency_Homo sapiens_hsa053400.48848249
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.48835845
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45642869
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45212549
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45118340
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43466652
91Antigen processing and presentation_Homo sapiens_hsa046120.43330742
92Caffeine metabolism_Homo sapiens_hsa002320.43271605
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.43164316
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42400601
95Taste transduction_Homo sapiens_hsa047420.41947006
96Herpes simplex infection_Homo sapiens_hsa051680.40259520
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.39056744
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38348610
99One carbon pool by folate_Homo sapiens_hsa006700.37880879
100Viral carcinogenesis_Homo sapiens_hsa052030.37813585
101Pertussis_Homo sapiens_hsa051330.36913429
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.36658110
103Retinol metabolism_Homo sapiens_hsa008300.35987406
104Hematopoietic cell lineage_Homo sapiens_hsa046400.35829188
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35527732
106mRNA surveillance pathway_Homo sapiens_hsa030150.35460335
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34224924
108Chemical carcinogenesis_Homo sapiens_hsa052040.34147722
109Salmonella infection_Homo sapiens_hsa051320.33920207
110Lysosome_Homo sapiens_hsa041420.32847964
111Basal cell carcinoma_Homo sapiens_hsa052170.32763334
112beta-Alanine metabolism_Homo sapiens_hsa004100.32192660
113GABAergic synapse_Homo sapiens_hsa047270.31671928
114Tyrosine metabolism_Homo sapiens_hsa003500.31387103
115Mineral absorption_Homo sapiens_hsa049780.31101044
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29922990
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27186702
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27131605
119Carbon metabolism_Homo sapiens_hsa012000.26001615
120Synaptic vesicle cycle_Homo sapiens_hsa047210.24357797
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23854621
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22923507
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22782071
124Leishmaniasis_Homo sapiens_hsa051400.22013860
125Morphine addiction_Homo sapiens_hsa050320.21271265
126Fatty acid degradation_Homo sapiens_hsa000710.20951916
127Insulin secretion_Homo sapiens_hsa049110.19532189
128Type I diabetes mellitus_Homo sapiens_hsa049400.19453248
129Measles_Homo sapiens_hsa051620.19096614
130Alcoholism_Homo sapiens_hsa050340.18318856
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17205328
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.17197625
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16814317
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15060935
135Renal cell carcinoma_Homo sapiens_hsa052110.13883487
136Apoptosis_Homo sapiens_hsa042100.12925943
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10838507
138Oocyte meiosis_Homo sapiens_hsa041140.10754573
139Phenylalanine metabolism_Homo sapiens_hsa003600.10711466

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