CUX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88068212
2positive regulation of gamma-delta T cell activation (GO:0046645)4.64624768
3definitive hemopoiesis (GO:0060216)4.38629183
4mitotic sister chromatid cohesion (GO:0007064)4.18681251
5positive regulation of B cell differentiation (GO:0045579)4.05215620
6antigen processing and presentation via MHC class Ib (GO:0002475)3.82629722
7regulation of gamma-delta T cell differentiation (GO:0045586)3.76146024
8regulation of gamma-delta T cell activation (GO:0046643)3.57137236
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.51694131
10protein-DNA complex disassembly (GO:0032986)3.48862730
11nucleosome disassembly (GO:0006337)3.48862730
12V(D)J recombination (GO:0033151)3.39466447
13negative regulation of granulocyte differentiation (GO:0030853)3.34614590
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32717520
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32717520
16positive regulation of granulocyte differentiation (GO:0030854)3.30462373
17negative regulation of phagocytosis (GO:0050765)3.30256192
18histone H3-K4 trimethylation (GO:0080182)3.29564283
19regulation of DNA endoreduplication (GO:0032875)3.25920877
20positive regulation of histone deacetylation (GO:0031065)3.20191469
21regulation of B cell differentiation (GO:0045577)3.12471713
22positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.06966219
23B cell receptor signaling pathway (GO:0050853)3.05751151
24DNA unwinding involved in DNA replication (GO:0006268)3.02444133
25cytoskeletal anchoring at plasma membrane (GO:0007016)2.99810110
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99434961
27T cell homeostasis (GO:0043029)2.99307285
28embryonic hemopoiesis (GO:0035162)2.98893037
29dosage compensation (GO:0007549)2.95787310
30megakaryocyte development (GO:0035855)2.90368027
31regulation of granulocyte differentiation (GO:0030852)2.89173637
32secretory granule organization (GO:0033363)2.86175406
33antigen processing and presentation of endogenous antigen (GO:0019883)2.85848025
34B cell homeostasis (GO:0001782)2.82665389
35adherens junction assembly (GO:0034333)2.80072512
36embryonic camera-type eye morphogenesis (GO:0048596)2.78429893
37negative regulation of cell size (GO:0045792)2.78365254
38positive regulation of gene expression, epigenetic (GO:0045815)2.77953271
39positive thymic T cell selection (GO:0045059)2.77858164
40positive regulation of receptor recycling (GO:0001921)2.76638241
41translesion synthesis (GO:0019985)2.75393639
42germ cell migration (GO:0008354)2.74765751
43mannose metabolic process (GO:0006013)2.72923766
44cell-substrate adherens junction assembly (GO:0007045)2.70856617
45focal adhesion assembly (GO:0048041)2.70856617
46positive T cell selection (GO:0043368)2.70259568
47regulation of interleukin-12 biosynthetic process (GO:0045075)2.69566385
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67209635
49positive regulation by organism of defense response of other organism involved in symbiotic interact2.67209635
50modulation by symbiont of host immune response (GO:0052553)2.67209635
51positive regulation by symbiont of host defense response (GO:0052509)2.67209635
52modulation by symbiont of host defense response (GO:0052031)2.67209635
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67209635
54semaphorin-plexin signaling pathway (GO:0071526)2.66324070
55lymphocyte homeostasis (GO:0002260)2.65077850
56negative regulation of RNA splicing (GO:0033119)2.64194151
57stress fiber assembly (GO:0043149)2.63150209
58regulation of NFAT protein import into nucleus (GO:0051532)2.63084399
59regulation of erythrocyte differentiation (GO:0045646)2.61293724
60DNA topological change (GO:0006265)2.60797146
61lymphoid progenitor cell differentiation (GO:0002320)2.60633920
62positive regulation of protein deacetylation (GO:0090312)2.60625064
63regulation of interferon-beta biosynthetic process (GO:0045357)2.60416984
64insulin-like growth factor receptor signaling pathway (GO:0048009)2.59781499
65hepatocyte apoptotic process (GO:0097284)2.59351817
66histone H3-K4 methylation (GO:0051568)2.59172064
67striated muscle atrophy (GO:0014891)2.55331355
68regulation of B cell receptor signaling pathway (GO:0050855)2.55312904
69Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54985186
70alternative mRNA splicing, via spliceosome (GO:0000380)2.54766612
71negative regulation of erythrocyte differentiation (GO:0045647)2.54672405
72epithelial cell-cell adhesion (GO:0090136)2.52935270
73T cell differentiation in thymus (GO:0033077)2.52883782
74mast cell activation (GO:0045576)2.52852839
75response to muramyl dipeptide (GO:0032495)2.50391464
76regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.49289939
77atrioventricular valve morphogenesis (GO:0003181)2.49025584
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.48377474
79peptidyl-lysine trimethylation (GO:0018023)2.48238833
80ribosomal small subunit assembly (GO:0000028)2.48107801
81regulation of glucose import in response to insulin stimulus (GO:2001273)2.47017767
82leukocyte homeostasis (GO:0001776)2.44741870
83regulation of necroptotic process (GO:0060544)2.43645089
84embryonic eye morphogenesis (GO:0048048)2.43169374
85pinocytosis (GO:0006907)2.42926211
86cell-cell junction maintenance (GO:0045217)2.42161634
87cellular response to epinephrine stimulus (GO:0071872)2.42033218
88lymph node development (GO:0048535)2.41032152
89negative regulation of vascular permeability (GO:0043116)2.40539429
90cell-substrate junction assembly (GO:0007044)2.40211745
91mRNA stabilization (GO:0048255)2.39580004
92RNA stabilization (GO:0043489)2.39580004
93glucocorticoid receptor signaling pathway (GO:0042921)2.39571855
94natural killer cell differentiation (GO:0001779)2.38908946
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.38004791
96regulation of histone H3-K9 methylation (GO:0051570)2.37665816
97T cell selection (GO:0045058)2.37559083
98regulation of fatty acid beta-oxidation (GO:0031998)2.37109920
99regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.35970829
100positive regulation of erythrocyte differentiation (GO:0045648)2.35216353
101skeletal muscle adaptation (GO:0043501)2.33976210
102negative regulation of stress fiber assembly (GO:0051497)2.33918046
103negative regulation of myotube differentiation (GO:0010832)2.33874255
104negative T cell selection (GO:0043383)2.32290831
105negative regulation of fatty acid transport (GO:2000192)2.31572701
106positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.31396297
107peptidyl-lysine dimethylation (GO:0018027)2.28798232
108positive regulation of natural killer cell differentiation (GO:0032825)2.28728406
109regulation of thymocyte apoptotic process (GO:0070243)2.28342662
110desmosome organization (GO:0002934)2.27922680
111interkinetic nuclear migration (GO:0022027)2.27080469
112regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.26818549
113cellular response to catecholamine stimulus (GO:0071870)2.26655930
114cellular response to monoamine stimulus (GO:0071868)2.26655930
115regulation of leukocyte degranulation (GO:0043300)2.26639560
116cellular response to zinc ion (GO:0071294)2.26512590
117actin nucleation (GO:0045010)2.26500354
118response to interferon-alpha (GO:0035455)2.26122593
119cardiac myofibril assembly (GO:0055003)2.25816120
120germinal center formation (GO:0002467)2.25635276
1213-UTR-mediated mRNA stabilization (GO:0070935)2.25489357
122fibroblast migration (GO:0010761)2.24660661
123carnitine shuttle (GO:0006853)2.24357373
124histamine transport (GO:0051608)2.23572412
125regulation of early endosome to late endosome transport (GO:2000641)2.22370143
126immunoglobulin mediated immune response (GO:0016064)2.22330768
127venous blood vessel morphogenesis (GO:0048845)2.22151847
128histone lysine methylation (GO:0034968)2.19782112
129protein targeting to plasma membrane (GO:0072661)2.19577467
130embryonic viscerocranium morphogenesis (GO:0048703)2.18886849
131cell junction maintenance (GO:0034331)2.18833934
132mucosal-associated lymphoid tissue development (GO:0048537)2.17680117
133Peyers patch development (GO:0048541)2.17680117
134cell migration involved in heart development (GO:0060973)2.17470856
135cytoplasmic mRNA processing body assembly (GO:0033962)2.17082444
136cellular hyperosmotic response (GO:0071474)2.16108183
137pericardium development (GO:0060039)2.15038878
138regulation of integrin-mediated signaling pathway (GO:2001044)2.14759938
139positive regulation of fatty acid beta-oxidation (GO:0032000)2.14323041
140protein localization to kinetochore (GO:0034501)2.14032105
141coronary vasculature morphogenesis (GO:0060977)2.13498102
142sarcomere organization (GO:0045214)2.13284546
143intracellular estrogen receptor signaling pathway (GO:0030520)2.13168230
144positive regulation of histone H3-K4 methylation (GO:0051571)2.13099491
145response to laminar fluid shear stress (GO:0034616)2.12735239
146activation of JUN kinase activity (GO:0007257)2.12453929
147regulation of stem cell maintenance (GO:2000036)2.11877643
148regulation of ARF protein signal transduction (GO:0032012)2.11217859
149epithelial cell differentiation involved in prostate gland development (GO:0060742)2.10623416
150positive regulation of blood vessel endothelial cell migration (GO:0043536)2.10158721
151activation of protein kinase A activity (GO:0034199)2.09959196
152negative regulation of homotypic cell-cell adhesion (GO:0034111)2.09036438
153eye morphogenesis (GO:0048592)2.08235471
154cardiac muscle hypertrophy (GO:0003300)2.07789286
155corticosteroid receptor signaling pathway (GO:0031958)2.07068217
156regulation of platelet aggregation (GO:0090330)2.06486431
157response to epinephrine (GO:0071871)2.06232553
158mesenchyme morphogenesis (GO:0072132)2.06068535
159cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.05393744
160response to catecholamine (GO:0071869)2.05101019
161response to monoamine (GO:0071867)2.05101019
162positive regulation of Cdc42 GTPase activity (GO:0043089)2.04482638
163response to fluid shear stress (GO:0034405)2.04397474
164cell communication by electrical coupling (GO:0010644)2.03952042
165vascular endothelial growth factor signaling pathway (GO:0038084)2.03844528
166regulation of integrin activation (GO:0033623)2.03439201
167negative regulation of glial cell proliferation (GO:0060253)2.03061414
168modulation by virus of host morphology or physiology (GO:0019048)2.02947872
169cellular response to fluid shear stress (GO:0071498)2.02023072
170planar cell polarity pathway involved in neural tube closure (GO:0090179)2.00091821
171cellular response to thyroid hormone stimulus (GO:0097067)1.99982264
172extracellular fibril organization (GO:0043206)1.99870692
173fibril organization (GO:0097435)1.99768752
174embryonic retina morphogenesis in camera-type eye (GO:0060059)1.99448781
175regulation of myeloid leukocyte mediated immunity (GO:0002886)1.98935506
176myofibril assembly (GO:0030239)1.98682405
177striated muscle adaptation (GO:0014888)1.98379687
178neutrophil activation involved in immune response (GO:0002283)1.98188223
179cardiac muscle contraction (GO:0060048)1.98112094
180negative regulation of protein localization to cell surface (GO:2000009)1.97636684
181vascular endothelial growth factor receptor signaling pathway (GO:0048010)1.97506935
182dopamine receptor signaling pathway (GO:0007212)1.96518397
183camera-type eye morphogenesis (GO:0048593)1.95435245
184muscle atrophy (GO:0014889)1.94650490
185negative regulation of focal adhesion assembly (GO:0051895)1.94288016
186negative regulation of cell junction assembly (GO:1901889)1.94288016
187negative regulation of adherens junction organization (GO:1903392)1.94288016
188actomyosin structure organization (GO:0031032)1.94199305
189regulation of T-helper 2 cell differentiation (GO:0045628)1.93884411
190cardiac muscle adaptation (GO:0014887)1.93374150
191cardiac muscle hypertrophy in response to stress (GO:0014898)1.93374150
192muscle hypertrophy in response to stress (GO:0003299)1.93374150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.26194182
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.41210606
3SCL_19346495_ChIP-Seq_HPC-7_Human4.20681224
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.93942479
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.80870744
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51681167
7* MYC_22102868_ChIP-Seq_BL_Human3.23813863
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.17397099
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12128396
10ESR2_21235772_ChIP-Seq_MCF-7_Human3.04189469
11VDR_21846776_ChIP-Seq_THP-1_Human3.03247682
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81216422
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.74240443
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.65177765
15* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.51215554
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40853702
17* VDR_24763502_ChIP-Seq_THP-1_Human2.37943987
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25586746
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.25133559
20RUNX_20019798_ChIP-Seq_JUKART_Human2.22567436
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22136554
22MYB_26560356_Chip-Seq_TH2_Human2.15476244
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15149184
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14419157
25UTX_26944678_Chip-Seq_JUKART_Human2.10375416
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09917420
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09413116
28* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07102307
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06297822
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05636016
31MAF_26560356_Chip-Seq_TH1_Human2.05124682
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05010903
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01298720
34* SPI1_23127762_ChIP-Seq_K562_Human2.01237881
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.98488507
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.95719948
37* KDM2B_26808549_Chip-Seq_K562_Human1.93073712
38EZH2_22144423_ChIP-Seq_EOC_Human1.91750276
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.90231568
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90176080
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84236695
42MYB_26560356_Chip-Seq_TH1_Human1.83943421
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81334418
44RACK7_27058665_Chip-Seq_MCF-7_Human1.78343285
45LXR_22292898_ChIP-Seq_THP-1_Human1.77839934
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.77716764
47* RUNX1_22412390_ChIP-Seq_EML_Mouse1.77214330
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74658569
49* KDM2B_26808549_Chip-Seq_DND41_Human1.74570553
50CIITA_25753668_ChIP-Seq_RAJI_Human1.73816302
51SPI1_23547873_ChIP-Seq_NB4_Human1.72817323
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71926083
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.70352878
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69511045
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68090940
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.66877831
57DROSHA_22980978_ChIP-Seq_HELA_Human1.59582010
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59213003
59* GATA1_19941826_ChIP-Seq_K562_Human1.57807100
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56572948
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54710996
62* RUNX1_27514584_Chip-Seq_MCF-7_Human1.51824784
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51072193
64* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49148541
65* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44176503
66* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43354686
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43308840
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42918216
69* AHR_22903824_ChIP-Seq_MCF-7_Human1.42406584
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.39594629
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38448226
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38416424
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37462796
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36643533
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.33978174
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.33909389
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.31783941
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30488010
79PU_27001747_Chip-Seq_BMDM_Mouse1.29181095
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28287942
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26901372
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26895553
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26742106
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26355470
85* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26206759
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.23932308
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22258246
88CLOCK_20551151_ChIP-Seq_293T_Human1.21949694
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21650239
90* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21484145
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21190340
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20910478
93* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20680686
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.20335854
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19845764
96* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19546930
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19131555
98* GATA3_27048872_Chip-Seq_THYMUS_Human1.17258302
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16894954
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.16682932
101* GATA2_19941826_ChIP-Seq_K562_Human1.16545842
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16223512
103* VDR_24787735_ChIP-Seq_THP-1_Human1.15603810
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15491588
105* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15487281
106CREB1_26743006_Chip-Seq_LNCaP_Human1.15076295
107* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14968382
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14926210
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14906303
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13524589
111* ARNT_22903824_ChIP-Seq_MCF-7_Human1.11671780
112* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10923723
113HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10634519
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08423903
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07993370
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07117445
117* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06928025
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06925603
119SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05553294
120EP300_21415370_ChIP-Seq_HL-1_Mouse1.03147519
121SMC4_20622854_ChIP-Seq_HELA_Human1.01924694
122ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01873145
123* TP53_23651856_ChIP-Seq_MEFs_Mouse1.01603208
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00828190
125GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99876361
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99767330
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99271158
128RARB_27405468_Chip-Seq_BRAIN_Mouse0.99003562
129ZNF263_19887448_ChIP-Seq_K562_Human0.98824027
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98280572
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97750707
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.97388609
133* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97243675
134* ISL1_27105846_Chip-Seq_CPCs_Mouse0.96979292
135RNF2_27304074_Chip-Seq_ESCs_Mouse0.96879622
136MAF_26560356_Chip-Seq_TH2_Human0.95626889
137* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94862262
138GATA1_22025678_ChIP-Seq_K562_Human0.94737719
139* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93709539
140* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93614037
141* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93306744
142STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92959042
143ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92641098
144HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91466060
145CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90526248
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90290893
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90252796
148EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90243676
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88641782
150NCOR1_26117541_ChIP-Seq_K562_Human0.86451283
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86429652
152PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84594586
153TBX20_22328084_ChIP-Seq_HEART_Mouse0.83441772
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.83441772
155* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83333489
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79877106
157SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79546277
158BRD4_25478319_ChIP-Seq_HGPS_Human0.79206224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.57293383
2MP0002396_abnormal_hematopoietic_system3.63626951
3MP0004808_abnormal_hematopoietic_stem3.20324069
4MP0009278_abnormal_bone_marrow3.12841542
5MP0002166_altered_tumor_susceptibility2.75248569
6MP0008438_abnormal_cutaneous_collagen2.74271579
7MP0005174_abnormal_tail_pigmentation2.69433485
8MP0003300_gastrointestinal_ulcer2.38683232
9MP0005397_hematopoietic_system_phenotyp2.27084126
10MP0001545_abnormal_hematopoietic_system2.27084126
11MP0001835_abnormal_antigen_presentation2.15037750
12MP0008004_abnormal_stomach_pH2.07410618
13MP0000685_abnormal_immune_system2.01147667
14MP0002095_abnormal_skin_pigmentation2.00075172
15MP0009780_abnormal_chondrocyte_physiolo1.96942096
16MP0004233_abnormal_muscle_weight1.91007779
17MP0004036_abnormal_muscle_relaxation1.89683720
18MP0010352_gastrointestinal_tract_polyps1.85920479
19MP0002006_tumorigenesis1.85887672
20MP0003763_abnormal_thymus_physiology1.85167251
21MP0005275_abnormal_skin_tensile1.82475734
22MP0006138_congestive_heart_failure1.82287558
23MP0000465_gastrointestinal_hemorrhage1.82206121
24MP0000751_myopathy1.79042707
25* MP0002398_abnormal_bone_marrow1.75496104
26MP0000015_abnormal_ear_pigmentation1.70014715
27MP0006054_spinal_hemorrhage1.69712019
28* MP0000703_abnormal_thymus_morphology1.69496923
29MP0001800_abnormal_humoral_immune1.69169840
30MP0005666_abnormal_adipose_tissue1.63400265
31MP0005076_abnormal_cell_differentiation1.61416198
32MP0002249_abnormal_larynx_morphology1.57297024
33MP0005670_abnormal_white_adipose1.56887923
34MP0004087_abnormal_muscle_fiber1.56803080
35MP0002452_abnormal_antigen_presenting1.56641057
36MP0010094_abnormal_chromosome_stability1.56119364
37MP0004130_abnormal_muscle_cell1.55526458
38MP0004947_skin_inflammation1.52460865
39MP0002420_abnormal_adaptive_immunity1.49937888
40* MP0005409_darkened_coat_color1.48239593
41MP0001790_abnormal_immune_system1.48210468
42MP0005387_immune_system_phenotype1.48210468
43MP0001819_abnormal_immune_cell1.47694848
44MP0001879_abnormal_lymphatic_vessel1.47344013
45MP0005464_abnormal_platelet_physiology1.47265541
46MP0005671_abnormal_response_to1.45997705
47MP0000490_abnormal_crypts_of1.45867402
48MP0003303_peritoneal_inflammation1.45542651
49MP0005375_adipose_tissue_phenotype1.44144627
50* MP0002722_abnormal_immune_system1.44016222
51* MP0000716_abnormal_immune_system1.43926739
52MP0008007_abnormal_cellular_replicative1.43185227
53MP0000689_abnormal_spleen_morphology1.40748848
54MP0003828_pulmonary_edema1.40704403
55MP0005503_abnormal_tendon_morphology1.39270142
56MP0002108_abnormal_muscle_morphology1.38620195
57MP0003566_abnormal_cell_adhesion1.38236921
58MP0003453_abnormal_keratinocyte_physiol1.34327925
59* MP0002723_abnormal_immune_serum1.33229600
60MP0010307_abnormal_tumor_latency1.31547773
61MP0001873_stomach_inflammation1.31188730
62MP0010155_abnormal_intestine_physiology1.30196661
63MP0003436_decreased_susceptibility_to1.29866028
64MP0004264_abnormal_extraembryonic_tissu1.28782328
65MP0000534_abnormal_ureter_morphology1.27580071
66MP0000462_abnormal_digestive_system1.25687885
67* MP0002429_abnormal_blood_cell1.24832253
68MP0000733_abnormal_muscle_development1.23890404
69MP0000003_abnormal_adipose_tissue1.23472386
70MP0003879_abnormal_hair_cell1.22801743
71MP0002419_abnormal_innate_immunity1.22515414
72MP0009785_altered_susceptibility_to1.21490407
73MP0005451_abnormal_body_composition1.20832325
74MP0003172_abnormal_lysosome_physiology1.20715272
75MP0002896_abnormal_bone_mineralization1.20408935
76MP0001958_emphysema1.19324771
77MP0005000_abnormal_immune_tolerance1.18760246
78MP0004858_abnormal_nervous_system1.17539320
79MP0003942_abnormal_urinary_system1.16674564
80MP0005075_abnormal_melanosome_morpholog1.16400417
81* MP0005025_abnormal_response_to1.15633461
82MP0003191_abnormal_cellular_cholesterol1.14778203
83* MP0002405_respiratory_system_inflammati1.14688372
84MP0003705_abnormal_hypodermis_morpholog1.13157282
85MP0000371_diluted_coat_color1.12718046
86MP0002332_abnormal_exercise_endurance1.12356130
87MP0003329_amyloid_beta_deposits1.12124539
88MP0000759_abnormal_skeletal_muscle1.10977725
89MP0003077_abnormal_cell_cycle1.09797234
90MP0001853_heart_inflammation1.09117300
91* MP0002098_abnormal_vibrissa_morphology1.07233218
92MP0009115_abnormal_fat_cell1.05295590
93MP0010630_abnormal_cardiac_muscle1.04115082
94* MP0000383_abnormal_hair_follicle1.03972626
95MP0000750_abnormal_muscle_regeneration1.03882709
96MP0003279_aneurysm1.02011865
97MP0008961_abnormal_basal_metabolism1.00908056
98MP0008057_abnormal_DNA_replication1.00501470
99MP0000767_abnormal_smooth_muscle1.00021120
100MP0003866_abnormal_defecation0.99270876
101MP0003943_abnormal_hepatobiliary_system0.98789861
102MP0005508_abnormal_skeleton_morphology0.97644003
103MP0003111_abnormal_nucleus_morphology0.97365700
104MP0010368_abnormal_lymphatic_system0.96817166
105MP0002127_abnormal_cardiovascular_syste0.95424626
106MP0003045_fibrosis0.92491571
107MP0002089_abnormal_postnatal_growth/wei0.91293036
108MP0000681_abnormal_thyroid_gland0.90277806
109MP0002060_abnormal_skin_morphology0.89302464
110MP0004484_altered_response_of0.88327109
111MP0002019_abnormal_tumor_incidence0.87946523
112MP0002972_abnormal_cardiac_muscle0.87881508
113MP0004185_abnormal_adipocyte_glucose0.87499628
114MP0004510_myositis0.87482144
115MP0009840_abnormal_foam_cell0.87465079
116MP0002877_abnormal_melanocyte_morpholog0.85907052
117MP0002933_joint_inflammation0.85776197
118MP0002928_abnormal_bile_duct0.84714823
119* MP0002075_abnormal_coat/hair_pigmentati0.84571293
120* MP0000377_abnormal_hair_follicle0.84339724
121MP0002009_preneoplasia0.84271290
122MP0002128_abnormal_blood_circulation0.83848704
123MP0005390_skeleton_phenotype0.83540481
124MP0000747_muscle_weakness0.82975197
125MP0008775_abnormal_heart_ventricle0.82214843
126MP0005620_abnormal_muscle_contractility0.82096804
127MP0000467_abnormal_esophagus_morphology0.82055560
128MP0004381_abnormal_hair_follicle0.82052488
129MP0005369_muscle_phenotype0.81509957
130MP0004084_abnormal_cardiac_muscle0.80672005
131MP0003075_altered_response_to0.79928383
132MP0002925_abnormal_cardiovascular_devel0.79893735
133MP0001915_intracranial_hemorrhage0.79695874
134MP0003567_abnormal_fetal_cardiomyocyte0.79644222
135MP0005595_abnormal_vascular_smooth0.79600352
136MP0002971_abnormal_brown_adipose0.79362221
137MP0002106_abnormal_muscle_physiology0.79018557
138MP0010234_abnormal_vibrissa_follicle0.77897531
139MP0003183_abnormal_peptide_metabolism0.77725492
140MP0004272_abnormal_basement_membrane0.76684318
141MP0002148_abnormal_hypersensitivity_rea0.76601344
142MP0002998_abnormal_bone_remodeling0.76439846
143MP0001851_eye_inflammation0.76309376
144MP0000427_abnormal_hair_cycle0.74947570
145MP0005385_cardiovascular_system_phenoty0.73760573
146MP0001544_abnormal_cardiovascular_syste0.73760573
147MP0005330_cardiomyopathy0.73386176
148MP0000579_abnormal_nail_morphology0.73166685
149MP0001614_abnormal_blood_vessel0.72630393
150MP0003123_paternal_imprinting0.72426844
151MP0001845_abnormal_inflammatory_respons0.71706685
152MP0000313_abnormal_cell_death0.71576926
153MP0004859_abnormal_synaptic_plasticity0.71512638
154MP0005023_abnormal_wound_healing0.68262658
155MP0001243_abnormal_dermal_layer0.67686040
156MP0005058_abnormal_lysosome_morphology0.66598104
157MP0003984_embryonic_growth_retardation0.66428477
158MP0003091_abnormal_cell_migration0.66217703
159MP0000647_abnormal_sebaceous_gland0.66148727
160MP0001849_ear_inflammation0.65993851
161MP0000266_abnormal_heart_morphology0.65666077
162MP0001533_abnormal_skeleton_physiology0.65534141
163MP0000858_altered_metastatic_potential0.65096703

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.67966273
2Obstructive sleep apnea (HP:0002870)3.42312745
3Thyroiditis (HP:0100646)3.28979062
4Hyperacusis (HP:0010780)3.18087402
5Recurrent viral infections (HP:0004429)3.16106169
6Panhypogammaglobulinemia (HP:0003139)3.06292306
7Long eyelashes (HP:0000527)2.89213493
8Cellulitis (HP:0100658)2.89117903
9Volvulus (HP:0002580)2.88055752
10Abnormality of B cell number (HP:0010975)2.83582766
11B lymphocytopenia (HP:0010976)2.83582766
12Chronic otitis media (HP:0000389)2.83391960
13Short 4th metacarpal (HP:0010044)2.82359063
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.82359063
15Hyporeflexia of lower limbs (HP:0002600)2.77244626
16Distal lower limb muscle weakness (HP:0009053)2.61858011
17Acute myeloid leukemia (HP:0004808)2.61718325
18Bundle branch block (HP:0011710)2.61238256
19IgM deficiency (HP:0002850)2.60246744
20Protrusio acetabuli (HP:0003179)2.59332815
21Recurrent fungal infections (HP:0002841)2.57506057
22Agammaglobulinemia (HP:0004432)2.57295465
23Hypoplasia of the thymus (HP:0000778)2.53913950
24Recurrent abscess formation (HP:0002722)2.53825243
25Distal lower limb amyotrophy (HP:0008944)2.50754909
26Thrombocytosis (HP:0001894)2.47573563
27Recurrent bacterial skin infections (HP:0005406)2.44028829
28Periodontitis (HP:0000704)2.40472589
29Elfin facies (HP:0004428)2.40114600
30Right ventricular cardiomyopathy (HP:0011663)2.39591883
31Hematochezia (HP:0002573)2.39255330
32Aneurysm (HP:0002617)2.35169056
33Asymmetric septal hypertrophy (HP:0001670)2.33293775
34Acute lymphatic leukemia (HP:0006721)2.30547236
35Dysmetric saccades (HP:0000641)2.27966130
36J-shaped sella turcica (HP:0002680)2.27863468
37Narrow palate (HP:0000189)2.27070353
38Cutis marmorata (HP:0000965)2.23950993
39Gastrointestinal inflammation (HP:0004386)2.22600539
40Increased density of long bones (HP:0006392)2.22131734
41Prolonged bleeding time (HP:0003010)2.20994930
42Asymmetry of the thorax (HP:0001555)2.19885264
43Colitis (HP:0002583)2.19312018
44Shallow orbits (HP:0000586)2.18200591
45Increased nuchal translucency (HP:0010880)2.17922100
46Abnormality of the right ventricle (HP:0001707)2.17814319
47Eosinophilia (HP:0001880)2.17676486
48Inflammation of the large intestine (HP:0002037)2.17649687
49Ventricular tachycardia (HP:0004756)2.17521662
50Bicuspid aortic valve (HP:0001647)2.16640283
51Macroorchidism (HP:0000053)2.16087975
52Myositis (HP:0100614)2.15678749
53Increased variability in muscle fiber diameter (HP:0003557)2.15536309
54Sudden death (HP:0001699)2.15297631
55Muscle fiber splitting (HP:0003555)2.14864569
56Absent frontal sinuses (HP:0002688)2.13921657
57Elevated erythrocyte sedimentation rate (HP:0003565)2.13894020
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.10462607
59Increased connective tissue (HP:0009025)2.08181017
60Hypoproteinemia (HP:0003075)2.07991839
61Autoimmune thrombocytopenia (HP:0001973)2.04629561
62Thin bony cortex (HP:0002753)2.04519910
63Abnormality of the distal phalanx of the thumb (HP:0009617)2.03627871
64Meningitis (HP:0001287)2.03526989
65Urethral obstruction (HP:0000796)2.02987121
66T lymphocytopenia (HP:0005403)2.02261799
67Mitral valve prolapse (HP:0001634)2.00477124
68Flat acetabular roof (HP:0003180)1.99788080
69Osteomyelitis (HP:0002754)1.99701298
70Abnormal delayed hypersensitivity skin test (HP:0002963)1.99135509
71Recurrent bronchitis (HP:0002837)1.99062726
72Abnormality of the frontal sinuses (HP:0002687)1.97844047
73Subaortic stenosis (HP:0001682)1.97279826
74Abnormality of the left ventricular outflow tract (HP:0011103)1.97279826
75Osteolytic defects of the phalanges of the hand (HP:0009771)1.96815659
76Osteolytic defects of the hand bones (HP:0009699)1.96815659
77Aortic dissection (HP:0002647)1.96576976
78Cervical subluxation (HP:0003308)1.96549394
79Abnormality of the intervertebral disk (HP:0005108)1.95093364
80Germ cell neoplasia (HP:0100728)1.94429552
81Neonatal hypoglycemia (HP:0001998)1.93843496
82Increased mean platelet volume (HP:0011877)1.93789725
83Obsessive-compulsive behavior (HP:0000722)1.93258599
84Papilloma (HP:0012740)1.91582868
85Verrucae (HP:0200043)1.91582868
86Deep philtrum (HP:0002002)1.91041386
87Hypercortisolism (HP:0001578)1.90625701
88Overgrowth (HP:0001548)1.89315602
89Bladder diverticulum (HP:0000015)1.88946977
90Spondylolisthesis (HP:0003302)1.88700360
91Abnormal platelet volume (HP:0011876)1.88545307
92Abnormality of skeletal muscle fiber size (HP:0012084)1.87248173
93Arterial tortuosity (HP:0005116)1.87228053
94Syringomyelia (HP:0003396)1.87206469
95Spinal cord lesions (HP:0100561)1.87206469
96Persistence of primary teeth (HP:0006335)1.86221882
97Mitral regurgitation (HP:0001653)1.85680385
98Mildly elevated creatine phosphokinase (HP:0008180)1.85413031
99Abnormality of T cell number (HP:0011839)1.85160777
100Dysostosis multiplex (HP:0000943)1.84906425
101Lip pit (HP:0100267)1.84721725
102Ulnar bowing (HP:0003031)1.84197023
103Aortic aneurysm (HP:0004942)1.83634810
104Purpura (HP:0000979)1.83613468
105Precocious puberty (HP:0000826)1.83512303
106Truncal obesity (HP:0001956)1.83072756
107Cerebral aneurysm (HP:0004944)1.82209650
108Renovascular hypertension (HP:0100817)1.81861511
109Severe combined immunodeficiency (HP:0004430)1.81758178
110Abnormality of the columella (HP:0009929)1.80916506
111Chest pain (HP:0100749)1.80311423
112Fragile skin (HP:0001030)1.79890001
113Renal duplication (HP:0000075)1.79841170
114Trigonocephaly (HP:0000243)1.78933245
115Lower limb amyotrophy (HP:0007210)1.78600450
116Impaired platelet aggregation (HP:0003540)1.77823360
117Abnormal platelet function (HP:0011869)1.77823360
118Deformed sella turcica (HP:0002681)1.77480444
119Hypoplasia of the iris (HP:0007676)1.77209559
120Pointed chin (HP:0000307)1.76588180
121Spontaneous hematomas (HP:0007420)1.76058325
122High pitched voice (HP:0001620)1.75977934
123Neoplasm of the heart (HP:0100544)1.75727602
124Thick eyebrow (HP:0000574)1.75389929
125Disproportionate tall stature (HP:0001519)1.74983434
126Vascular tortuosity (HP:0004948)1.74383075
127Abnormality of the 4th metacarpal (HP:0010012)1.74346025
128Interstitial pulmonary disease (HP:0006530)1.74188253
129Long toe (HP:0010511)1.73883376
130Difficulty running (HP:0009046)1.73162706
131Wormian bones (HP:0002645)1.72040618
132Granulocytopenia (HP:0001913)1.72025091
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71218609
134Advanced eruption of teeth (HP:0006288)1.71178023
135Exercise-induced myalgia (HP:0003738)1.71001352
136Depressed nasal tip (HP:0000437)1.69817210
137Broad palm (HP:0001169)1.68916766
138Prominent nose (HP:0000448)1.68014128
139Stroke (HP:0001297)1.67784086
140Esophageal varix (HP:0002040)1.67759587
141Atrial fibrillation (HP:0005110)1.67143198
142Ectopic kidney (HP:0000086)1.67130778
143Abnormality of eosinophils (HP:0001879)1.66777689
144Abnormal atrioventricular conduction (HP:0005150)1.66683113
145Vertebral compression fractures (HP:0002953)1.66511248
146Lymphangioma (HP:0100764)1.66398045
147Abnormality of T cells (HP:0002843)1.66083908
148Menorrhagia (HP:0000132)1.65810357
149Viral hepatitis (HP:0006562)1.65608346
150Overriding aorta (HP:0002623)1.65517426
151Hyperparathyroidism (HP:0000843)1.65507633
152Joint laxity (HP:0001388)1.64750924
153Abnormality of the thoracic spine (HP:0100711)1.64588544
154Venous abnormality (HP:0002624)1.64118994
155Broad face (HP:0000283)1.64086835
156Pili torti (HP:0003777)1.63981255
157Ventricular fibrillation (HP:0001663)1.63600367
158Abnormality of the parietal bone (HP:0002696)1.63075889
159Petechiae (HP:0000967)1.62779976
160Sepsis (HP:0100806)1.62703583
161EMG: neuropathic changes (HP:0003445)1.62364834
162Rectal prolapse (HP:0002035)1.62281677
163Bowel diverticulosis (HP:0005222)1.62034809
164Leukocytosis (HP:0001974)1.60556197
165Urinary glycosaminoglycan excretion (HP:0003541)1.59690269
166Mucopolysacchariduria (HP:0008155)1.59690269
167Ventricular arrhythmia (HP:0004308)1.59529949
168Tented upper lip vermilion (HP:0010804)1.58006631
169Testicular neoplasm (HP:0010788)1.57381173
170Flat cornea (HP:0007720)1.57295841
171Syncope (HP:0001279)1.56495447
172Epistaxis (HP:0000421)1.55338740
173Abnormality of the sella turcica (HP:0002679)1.55288631
174Growth hormone excess (HP:0000845)1.54499049
175Patellar dislocation (HP:0002999)1.54070841
176Abnormality of the nasal septum (HP:0000419)1.53731599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.95054630
2MAP3K102.97962959
3MAP4K12.85222229
4KIT2.70126057
5PRPF4B2.29154435
6CAMK1D2.08535257
7CDK122.05878349
8CAMK1G2.00946554
9BTK1.98630517
10PKN21.94516126
11TRIB31.92952591
12TTN1.88421262
13CSF1R1.81818272
14TGFBR21.75368867
15TGFBR11.73382835
16SMG11.71232470
17SIK21.65700020
18STK41.63680620
19FGFR31.62643240
20FLT31.50213780
21BRD41.49985070
22NEK21.48031015
23RPS6KA41.46867611
24TEC1.46754353
25ZAP701.37026035
26CDC42BPA1.36567707
27PTK61.36551423
28ERN11.36060627
29CDK61.35487686
30LRRK21.34801317
31STK101.31265581
32SYK1.31094928
33PDGFRA1.30168160
34SIK31.27074733
35CDC71.27071281
36DMPK1.26567874
37TXK1.22725566
38EPHB11.22700889
39RPS6KB21.20862298
40TYK21.19896798
41PRKD21.16518583
42LMTK21.15593968
43TAOK11.14913033
44CLK11.14483877
45TAOK31.12926936
46IRAK31.12738610
47HCK1.10363572
48TRPM71.09733098
49HIPK21.08144254
50RET1.07078259
51FGFR21.06960974
52BLK1.06795749
53MYLK1.04051051
54YES11.03673929
55CHUK1.02961701
56PDPK11.01785323
57PIM11.00777889
58PAK41.00452118
59MAP3K60.99577356
60* ATR0.99552850
61DYRK1B0.99300636
62PIK3CA0.98802347
63ZAK0.98139730
64MAP2K30.98106224
65RIPK40.97573241
66ITK0.97230904
67ICK0.96537849
68TNK20.93254222
69WNK10.89925798
70TBK10.89657046
71CDK90.89044928
72AKT30.88763210
73SGK30.87832757
74CDK40.87487817
75MAP3K70.86750459
76RIPK10.86316868
77LATS20.86278125
78JAK30.86126980
79STK30.85665198
80EPHA20.84038065
81SGK2230.83856903
82SGK4940.83856903
83FES0.82848718
84IRAK40.82663487
85MAP3K30.80916293
86BMX0.80053046
87PRKD30.78532455
88SIK10.78007540
89PTK20.77993889
90CCNB10.76613966
91JAK10.76296086
92PRKD10.75380173
93STK240.75176361
94MAP2K20.74421212
95PDGFRB0.73285031
96LCK0.73092576
97DDR20.72620425
98ERBB30.72589580
99PDK10.70557746
100MAP3K10.70170527
101IKBKE0.69283232
102DAPK20.68890223
103MAPKAPK30.66525447
104RPS6KA20.65711810
105* MTOR0.65394768
106MELK0.64743868
107NLK0.64651381
108SGK20.64546003
109CAMK40.63713912
110MKNK10.63203331
111RPS6KA60.62339155
112MST1R0.61839615
113STK380.61656074
114ERBB20.61416452
115RPS6KC10.61358177
116RPS6KL10.61358177
117LYN0.61196745
118MAPK110.58142139
119LATS10.57853448
120CAMK10.57202452
121MARK20.57009301
122MAPK70.56007704
123PASK0.55904032
124AURKB0.55658739
125MAP2K10.54945690
126MAPKAPK20.54812267
127PAK20.54492582
128CDK70.54262275
129DYRK30.53482912
130TAOK20.53461825
131PRKAA10.52580235
132PIM20.51897085
133FGFR40.48853320
134MAPK40.48668730
135PRKAA20.48218716
136IKBKB0.47969498
137CSK0.47035790
138NEK60.46843054
139PRKCH0.46690513
140SCYL20.46043665
141KSR20.45939378
142MATK0.45893239
143NEK90.45766385
144MAPK120.45478429
145PIK3CG0.45379230
146EPHA30.44954319
147MAPK100.44650166
148FER0.43768558
149IRAK20.41489506
150MAPK30.39668458
151MAPK80.38756577
152ROCK10.38703291
153MET0.38464027
154RPS6KA10.38462635

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.30013601
2B cell receptor signaling pathway_Homo sapiens_hsa046622.05768277
3Chronic myeloid leukemia_Homo sapiens_hsa052201.89959514
4Non-homologous end-joining_Homo sapiens_hsa034501.78723485
5DNA replication_Homo sapiens_hsa030301.69471626
6Osteoclast differentiation_Homo sapiens_hsa043801.64775058
7Viral myocarditis_Homo sapiens_hsa054161.61173928
8Leishmaniasis_Homo sapiens_hsa051401.61001049
9Acute myeloid leukemia_Homo sapiens_hsa052211.56811262
10Transcriptional misregulation in cancer_Homo sapiens_hsa052021.56803373
11Small cell lung cancer_Homo sapiens_hsa052221.50141717
12Measles_Homo sapiens_hsa051621.49121936
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48512246
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46886140
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46276854
16Notch signaling pathway_Homo sapiens_hsa043301.45868665
17Hematopoietic cell lineage_Homo sapiens_hsa046401.45193515
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.40236793
19Toxoplasmosis_Homo sapiens_hsa051451.39722612
20MicroRNAs in cancer_Homo sapiens_hsa052061.39154818
21Platelet activation_Homo sapiens_hsa046111.38296922
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.37585371
23Colorectal cancer_Homo sapiens_hsa052101.35038021
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34844063
25Pancreatic cancer_Homo sapiens_hsa052121.34647592
26Phospholipase D signaling pathway_Homo sapiens_hsa040721.34624133
27Renal cell carcinoma_Homo sapiens_hsa052111.34555728
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34376061
29Lysine degradation_Homo sapiens_hsa003101.33976283
30Base excision repair_Homo sapiens_hsa034101.32697992
31Antigen processing and presentation_Homo sapiens_hsa046121.29999268
32Non-small cell lung cancer_Homo sapiens_hsa052231.28683873
33Herpes simplex infection_Homo sapiens_hsa051681.28106431
34Cell cycle_Homo sapiens_hsa041101.27295812
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26281463
36Hepatitis B_Homo sapiens_hsa051611.25348461
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24302213
38Choline metabolism in cancer_Homo sapiens_hsa052311.24239385
39HTLV-I infection_Homo sapiens_hsa051661.20859822
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19328298
41GnRH signaling pathway_Homo sapiens_hsa049121.19017305
42ErbB signaling pathway_Homo sapiens_hsa040121.17634193
43Endometrial cancer_Homo sapiens_hsa052131.17531717
44T cell receptor signaling pathway_Homo sapiens_hsa046601.14750392
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.14349986
46Dorso-ventral axis formation_Homo sapiens_hsa043201.14349447
47Proteoglycans in cancer_Homo sapiens_hsa052051.13906024
48Bladder cancer_Homo sapiens_hsa052191.11660650
49Insulin signaling pathway_Homo sapiens_hsa049101.11577691
50Estrogen signaling pathway_Homo sapiens_hsa049151.10253559
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.08291814
52Viral carcinogenesis_Homo sapiens_hsa052031.08076638
53Long-term potentiation_Homo sapiens_hsa047201.07833371
54Gap junction_Homo sapiens_hsa045401.07714450
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07582800
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07123720
57Focal adhesion_Homo sapiens_hsa045101.05628119
58Influenza A_Homo sapiens_hsa051641.05279631
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.05214854
60Mismatch repair_Homo sapiens_hsa034301.05114008
61AMPK signaling pathway_Homo sapiens_hsa041521.03308744
62Shigellosis_Homo sapiens_hsa051311.03231990
63Apoptosis_Homo sapiens_hsa042101.01672845
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99117271
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.99057520
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97268660
67Systemic lupus erythematosus_Homo sapiens_hsa053220.96606511
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96585815
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96390258
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96368622
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.96138946
72Type II diabetes mellitus_Homo sapiens_hsa049300.94654960
73Adherens junction_Homo sapiens_hsa045200.94071582
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93665208
75Basal cell carcinoma_Homo sapiens_hsa052170.92743870
76Dilated cardiomyopathy_Homo sapiens_hsa054140.92446333
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92430845
78Oxytocin signaling pathway_Homo sapiens_hsa049210.91287819
79Gastric acid secretion_Homo sapiens_hsa049710.90716518
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.90306840
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89912682
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89904091
83Pathways in cancer_Homo sapiens_hsa052000.89065307
84Homologous recombination_Homo sapiens_hsa034400.88215087
85p53 signaling pathway_Homo sapiens_hsa041150.87760206
86Renin secretion_Homo sapiens_hsa049240.87107438
87Prostate cancer_Homo sapiens_hsa052150.86989260
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86360461
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.85530382
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85408113
91Tuberculosis_Homo sapiens_hsa051520.85172072
92TNF signaling pathway_Homo sapiens_hsa046680.85138458
93Glioma_Homo sapiens_hsa052140.85126888
94FoxO signaling pathway_Homo sapiens_hsa040680.83896027
95Hepatitis C_Homo sapiens_hsa051600.82820645
96Long-term depression_Homo sapiens_hsa047300.82482907
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82406134
98Other glycan degradation_Homo sapiens_hsa005110.81869317
99Chemokine signaling pathway_Homo sapiens_hsa040620.81846143
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80142702
101mTOR signaling pathway_Homo sapiens_hsa041500.80122163
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.79973129
103Pancreatic secretion_Homo sapiens_hsa049720.79451591
104Salmonella infection_Homo sapiens_hsa051320.78497974
105Cholinergic synapse_Homo sapiens_hsa047250.78258647
106ECM-receptor interaction_Homo sapiens_hsa045120.77667954
107Fanconi anemia pathway_Homo sapiens_hsa034600.75842032
108Melanoma_Homo sapiens_hsa052180.75510988
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74977172
110Thyroid cancer_Homo sapiens_hsa052160.74835867
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74520726
112Melanogenesis_Homo sapiens_hsa049160.74117813
113Insulin resistance_Homo sapiens_hsa049310.73512269
114Pertussis_Homo sapiens_hsa051330.72375891
115Thyroid hormone synthesis_Homo sapiens_hsa049180.72274629
116Legionellosis_Homo sapiens_hsa051340.71166107
117Glucagon signaling pathway_Homo sapiens_hsa049220.71044659
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70405787
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70156191
120Rap1 signaling pathway_Homo sapiens_hsa040150.69860438
121N-Glycan biosynthesis_Homo sapiens_hsa005100.69209390
122Salivary secretion_Homo sapiens_hsa049700.69113414
123Lysosome_Homo sapiens_hsa041420.68196770
124Ovarian steroidogenesis_Homo sapiens_hsa049130.68128400
125Malaria_Homo sapiens_hsa051440.67521620
126HIF-1 signaling pathway_Homo sapiens_hsa040660.67234714
127Spliceosome_Homo sapiens_hsa030400.66939706
128cAMP signaling pathway_Homo sapiens_hsa040240.66934123
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66624182
130MAPK signaling pathway_Homo sapiens_hsa040100.66294053
131Endocytosis_Homo sapiens_hsa041440.66092742
132Circadian entrainment_Homo sapiens_hsa047130.64924926
133Pentose phosphate pathway_Homo sapiens_hsa000300.64739803
134Prolactin signaling pathway_Homo sapiens_hsa049170.64309548
135Inositol phosphate metabolism_Homo sapiens_hsa005620.63145202
136VEGF signaling pathway_Homo sapiens_hsa043700.61136889
137Tight junction_Homo sapiens_hsa045300.60265431
138mRNA surveillance pathway_Homo sapiens_hsa030150.58422210
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57661520
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57146366
141Epstein-Barr virus infection_Homo sapiens_hsa051690.56786124
142Calcium signaling pathway_Homo sapiens_hsa040200.56614011
143Prion diseases_Homo sapiens_hsa050200.56263165
144Amoebiasis_Homo sapiens_hsa051460.56130824
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55926686
146Wnt signaling pathway_Homo sapiens_hsa043100.53815433
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52108120
148Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51591388

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