CUTC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.60636341
2muscle filament sliding (GO:0030049)6.60636341
3actin-mediated cell contraction (GO:0070252)5.33898823
4sarcoplasmic reticulum calcium ion transport (GO:0070296)5.24143407
5regulation of skeletal muscle contraction (GO:0014819)5.12450955
6skeletal muscle contraction (GO:0003009)4.90976707
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.87039173
8ribosomal small subunit assembly (GO:0000028)4.67285678
9DNA deamination (GO:0045006)4.64613982
10regulation of relaxation of muscle (GO:1901077)4.61114675
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.20094203
12ATP synthesis coupled proton transport (GO:0015986)4.20094203
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.00562669
14respiratory electron transport chain (GO:0022904)3.94951571
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.90660189
16electron transport chain (GO:0022900)3.85559352
17ubiquinone biosynthetic process (GO:0006744)3.80517792
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.76220020
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.76220020
20IMP biosynthetic process (GO:0006188)3.74040228
21viral transcription (GO:0019083)3.72313947
22cullin deneddylation (GO:0010388)3.67121061
23translational termination (GO:0006415)3.64062614
24protein complex biogenesis (GO:0070271)3.59829577
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58705694
26cytochrome complex assembly (GO:0017004)3.57663847
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57016762
28tricarboxylic acid cycle (GO:0006099)3.56542277
29mitochondrial respiratory chain complex assembly (GO:0033108)3.54990980
30NADH metabolic process (GO:0006734)3.50232278
31creatine metabolic process (GO:0006600)3.46111922
32actin filament-based movement (GO:0030048)3.45866172
33positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.44603207
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.41820025
35chaperone-mediated protein transport (GO:0072321)3.41085324
36negative regulation of ligase activity (GO:0051352)3.38611460
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38611460
38ubiquinone metabolic process (GO:0006743)3.37167687
39response to muscle activity (GO:0014850)3.37076861
40protein deneddylation (GO:0000338)3.35842904
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35735196
42maturation of SSU-rRNA (GO:0030490)3.34997794
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34101946
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.34101946
45NADH dehydrogenase complex assembly (GO:0010257)3.34101946
46glycogen biosynthetic process (GO:0005978)3.33547680
47glucan biosynthetic process (GO:0009250)3.33547680
48purine nucleotide salvage (GO:0032261)3.33404068
49cotranslational protein targeting to membrane (GO:0006613)3.32184873
50protein targeting to ER (GO:0045047)3.30310434
51antigen processing and presentation of endogenous antigen (GO:0019883)3.29684714
52ribosome assembly (GO:0042255)3.29307345
53striated muscle contraction (GO:0006941)3.29239744
54CENP-A containing nucleosome assembly (GO:0034080)3.28560536
55translational elongation (GO:0006414)3.27300745
56chromatin remodeling at centromere (GO:0031055)3.26512619
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26127253
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25959741
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22170523
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22170523
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22170523
62inner mitochondrial membrane organization (GO:0007007)3.20906004
63protein localization to endoplasmic reticulum (GO:0070972)3.20727817
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18872560
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18872560
66ribosomal small subunit biogenesis (GO:0042274)3.18161700
67regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.16319391
68aerobic respiration (GO:0009060)3.11413110
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11054836
70protein neddylation (GO:0045116)3.11043850
71protein targeting to mitochondrion (GO:0006626)3.10047004
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.08649283
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08649283
74glycogen catabolic process (GO:0005980)3.08178299
75positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05687079
76regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.05585891
77establishment of integrated proviral latency (GO:0075713)3.03193878
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.02773410
79myofibril assembly (GO:0030239)3.01984030
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00868106
81telomere maintenance via semi-conservative replication (GO:0032201)2.99508566
82positive regulation of ligase activity (GO:0051351)2.98844702
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98474799
84transcription from mitochondrial promoter (GO:0006390)2.98067642
85response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.97548370
86DNA strand elongation (GO:0022616)2.97408316
87quinone biosynthetic process (GO:1901663)2.96064940
88DNA strand elongation involved in DNA replication (GO:0006271)2.95946018
89purine nucleobase biosynthetic process (GO:0009113)2.95266066
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.95204252
91L-phenylalanine metabolic process (GO:0006558)2.95204252
92purine nucleoside monophosphate biosynthetic process (GO:0009127)2.93470146
93purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.93470146
94nucleobase biosynthetic process (GO:0046112)2.92235869
95sarcomere organization (GO:0045214)2.91539443
96branched-chain amino acid catabolic process (GO:0009083)2.90803755
97skeletal muscle fiber development (GO:0048741)2.90217625
98proteasome assembly (GO:0043248)2.89197712
99regulation of glucokinase activity (GO:0033131)2.87748936
100regulation of hexokinase activity (GO:1903299)2.87748936
101protein localization to mitochondrion (GO:0070585)2.85578184
102serine family amino acid biosynthetic process (GO:0009070)2.85183761
103myotube cell development (GO:0014904)2.84140223
104aspartate family amino acid catabolic process (GO:0009068)2.84014915
105heart contraction (GO:0060047)2.83442711
106heart process (GO:0003015)2.83442711
107ribosomal large subunit biogenesis (GO:0042273)2.81639554
108glycine metabolic process (GO:0006544)2.79923091
109L-phenylalanine catabolic process (GO:0006559)2.79738521
110erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.79738521
111translational initiation (GO:0006413)2.75834992
112response to interferon-beta (GO:0035456)2.75599321
113NAD biosynthetic process (GO:0009435)2.74920622
114viral life cycle (GO:0019058)2.74621256
115indole-containing compound catabolic process (GO:0042436)2.72706095
116indolalkylamine catabolic process (GO:0046218)2.72706095
117tryptophan catabolic process (GO:0006569)2.72706095
118aromatic amino acid family catabolic process (GO:0009074)2.72168355
119imidazole-containing compound metabolic process (GO:0052803)2.71017828
120antigen processing and presentation via MHC class Ib (GO:0002475)2.70154919
121L-methionine salvage (GO:0071267)2.69972243
122L-methionine biosynthetic process (GO:0071265)2.69972243
123amino acid salvage (GO:0043102)2.69972243
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69818577
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.69019662
126cellular protein complex disassembly (GO:0043624)2.68951776
127tryptophan metabolic process (GO:0006568)2.67878167
128L-serine metabolic process (GO:0006563)2.67658495
129regulation of RIG-I signaling pathway (GO:0039535)2.66401178
130nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.65476648
131rRNA modification (GO:0000154)2.64964061
132DNA replication initiation (GO:0006270)2.64790263
133pteridine-containing compound biosynthetic process (GO:0042559)2.64002161
134kynurenine metabolic process (GO:0070189)2.62530001
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60756909
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59845546
137telomere maintenance via recombination (GO:0000722)2.59156088
138AMP metabolic process (GO:0046033)2.57944934
139valine metabolic process (GO:0006573)2.57031354
140ribonucleoprotein complex biogenesis (GO:0022613)2.56221448
141purine nucleobase metabolic process (GO:0006144)2.55508377
142purine-containing compound salvage (GO:0043101)2.55229733
143regulation of mitochondrial translation (GO:0070129)2.54435817
144nicotinamide nucleotide biosynthetic process (GO:0019359)2.54007907
145pyridine nucleotide biosynthetic process (GO:0019363)2.54007907
146cellular response to interferon-beta (GO:0035458)2.52459087
147metallo-sulfur cluster assembly (GO:0031163)2.51535197
148iron-sulfur cluster assembly (GO:0016226)2.51535197
149folic acid metabolic process (GO:0046655)2.50394121
150purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.49749933
151antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.49364847
152translation (GO:0006412)2.49001133
153nucleoside salvage (GO:0043174)2.47684785
154serine family amino acid metabolic process (GO:0009069)2.45632020
155positive regulation of B cell differentiation (GO:0045579)2.45282090
156cellular metabolic compound salvage (GO:0043094)2.45278249
157pseudouridine synthesis (GO:0001522)2.43717772
158oxidative phosphorylation (GO:0006119)2.43108615
159tetrahydrofolate metabolic process (GO:0046653)2.41902929
160regulation of cellular amino acid metabolic process (GO:0006521)2.41409371
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.39613469
162methionine metabolic process (GO:0006555)2.39142782
163S-adenosylmethionine metabolic process (GO:0046500)2.38015561
164IMP metabolic process (GO:0046040)2.36372318
165deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.36100778
166regulation of triglyceride catabolic process (GO:0010896)2.35885302
167pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.33607288
168respiratory chain complex IV assembly (GO:0008535)2.31849305
169sulfur amino acid biosynthetic process (GO:0000097)2.31521675
170negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.31425071
171pteridine-containing compound metabolic process (GO:0042558)2.31092605
172cysteine metabolic process (GO:0006534)2.30881851
173positive regulation of interferon-alpha production (GO:0032727)2.30695237
174immunoglobulin mediated immune response (GO:0016064)2.30363128
175rRNA methylation (GO:0031167)2.30301609
176positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.29912908
177sulfur amino acid catabolic process (GO:0000098)2.29559647
178necroptotic process (GO:0070266)2.29094644
179deoxyribose phosphate biosynthetic process (GO:0046385)2.28657555
1802-deoxyribonucleotide biosynthetic process (GO:0009265)2.28657555
181methionine biosynthetic process (GO:0009086)2.27442243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.35345750
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49136295
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.36020603
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.25329536
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.16339410
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01387905
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.00617529
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80070776
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.79044241
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75135493
11* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69770156
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.69754101
13GATA1_22025678_ChIP-Seq_K562_Human2.55553181
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.43283725
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.40880669
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39244505
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38490565
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35514469
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29121374
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23551731
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18218319
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.08542779
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06997138
24VDR_23849224_ChIP-Seq_CD4+_Human2.05175388
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.03223388
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.00742821
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98292525
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93899194
29FOXP3_21729870_ChIP-Seq_TREG_Human1.90694726
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88652648
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88029212
32* SRF_21415370_ChIP-Seq_HL-1_Mouse1.87657196
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86939145
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84611132
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84043489
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.83609009
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80784331
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79534295
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79490633
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.75883629
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75458257
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74265491
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73472733
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71391688
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69652499
46SCL_19346495_ChIP-Seq_HPC-7_Human1.69080950
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68803918
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66461453
49XRN2_22483619_ChIP-Seq_HELA_Human1.66089729
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63476063
51* DCP1A_22483619_ChIP-Seq_HELA_Human1.62464953
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60485747
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58323320
54* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56967682
55* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56705886
56SPI1_23547873_ChIP-Seq_NB4_Human1.55701700
57GABP_19822575_ChIP-Seq_HepG2_Human1.55578233
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52426082
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52156040
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51405563
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50854250
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48828031
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46885056
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.46697596
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45256826
66ELK1_19687146_ChIP-ChIP_HELA_Human1.41882178
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41717416
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.37281712
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36833496
70ZNF274_21170338_ChIP-Seq_K562_Hela1.35765838
71AR_21909140_ChIP-Seq_LNCAP_Human1.28664798
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27009297
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24497971
74VDR_22108803_ChIP-Seq_LS180_Human1.23910045
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23293135
76* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21991257
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21730881
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20361953
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19632241
80LXR_22158963_ChIP-Seq_LIVER_Mouse1.19057973
81* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19001782
82* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17521898
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16491785
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15848132
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.15199083
86CIITA_25753668_ChIP-Seq_RAJI_Human1.14781762
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13255250
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12885874
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.12771996
90MYC_22102868_ChIP-Seq_BL_Human1.12226903
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09962281
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09416124
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.08957310
94TTF2_22483619_ChIP-Seq_HELA_Human1.08882043
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08278136
96FOXM1_23109430_ChIP-Seq_U2OS_Human1.08265633
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08245491
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07378958
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07370784
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06988191
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06974824
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06884581
103* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06747515
104HTT_18923047_ChIP-ChIP_STHdh_Human1.05661284
105* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05220249
106IGF1R_20145208_ChIP-Seq_DFB_Human1.04501934
107FUS_26573619_Chip-Seq_HEK293_Human1.03070270
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02762794
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02048608
110EWS_26573619_Chip-Seq_HEK293_Human1.01663101
111IRF8_27001747_Chip-Seq_BMDM_Mouse1.00507066
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99929189
113MYB_26560356_Chip-Seq_TH2_Human0.99137821
114* MYB_26560356_Chip-Seq_TH1_Human0.98344170
115* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95261436
116KDM5A_27292631_Chip-Seq_BREAST_Human0.94863524
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93617913
118MYC_18940864_ChIP-ChIP_HL60_Human0.93099192
119* RUNX1_22412390_ChIP-Seq_EML_Mouse0.92961037
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92498439
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92194016
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91142077
123MAF_26560356_Chip-Seq_TH1_Human0.89380584
124MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89209405
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.86561068
126* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86348156
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84710775
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.84259017
129TP53_22573176_ChIP-Seq_HFKS_Human0.84050407
130MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81845672
131* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81135357
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80911848
133GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78163857
134SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76934766
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76009832
136NANOG_19829295_ChIP-Seq_ESCs_Human0.75600528
137SOX2_19829295_ChIP-Seq_ESCs_Human0.75600528
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.74786637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.29235909
2MP0000749_muscle_degeneration4.64019664
3MP0000751_myopathy4.00057750
4MP0002139_abnormal_hepatobiliary_system3.72837329
5MP0005360_urolithiasis3.35708502
6MP0004036_abnormal_muscle_relaxation3.30149600
7MP0003806_abnormal_nucleotide_metabolis3.25540359
8MP0008875_abnormal_xenobiotic_pharmacok3.11543849
9MP0001835_abnormal_antigen_presentation2.94934837
10MP0005085_abnormal_gallbladder_physiolo2.93137826
11MP0002837_dystrophic_cardiac_calcinosis2.89227763
12MP0005365_abnormal_bile_salt2.83837015
13MP0002106_abnormal_muscle_physiology2.81464205
14MP0004084_abnormal_cardiac_muscle2.61195956
15MP0004147_increased_porphyrin_level2.58800152
16MP0005330_cardiomyopathy2.46525950
17MP0000747_muscle_weakness2.45533802
18MP0002269_muscular_atrophy2.42700358
19MP0009785_altered_susceptibility_to2.42605814
20MP0005369_muscle_phenotype2.37341814
21MP0005671_abnormal_response_to2.34389751
22MP0004087_abnormal_muscle_fiber2.28766316
23MP0001764_abnormal_homeostasis2.27074373
24MP0000759_abnormal_skeletal_muscle2.26637762
25MP0002396_abnormal_hematopoietic_system2.16276753
26MP0004233_abnormal_muscle_weight2.14063848
27MP0004215_abnormal_myocardial_fiber2.12272237
28MP0003693_abnormal_embryo_hatching2.09001398
29MP0003724_increased_susceptibility_to2.06023675
30MP0005620_abnormal_muscle_contractility2.02236945
31MP0000685_abnormal_immune_system2.01900249
32MP0002332_abnormal_exercise_endurance1.98645267
33MP0003656_abnormal_erythrocyte_physiolo1.92881247
34MP0006036_abnormal_mitochondrial_physio1.91620851
35MP0000372_irregular_coat_pigmentation1.91542331
36MP0005451_abnormal_body_composition1.90510899
37MP0009840_abnormal_foam_cell1.89445485
38MP0005025_abnormal_response_to1.88645825
39MP0003191_abnormal_cellular_cholesterol1.87776991
40MP0010094_abnormal_chromosome_stability1.85523259
41MP0003436_decreased_susceptibility_to1.79536686
42MP0001800_abnormal_humoral_immune1.79405146
43MP0003186_abnormal_redox_activity1.79034980
44MP0000750_abnormal_muscle_regeneration1.77384097
45MP0002166_altered_tumor_susceptibility1.69945782
46MP0010329_abnormal_lipoprotein_level1.68946361
47MP0002148_abnormal_hypersensitivity_rea1.65645774
48MP0002972_abnormal_cardiac_muscle1.65634531
49MP0008469_abnormal_protein_level1.63941763
50MP0005397_hematopoietic_system_phenotyp1.63621205
51MP0001545_abnormal_hematopoietic_system1.63621205
52MP0002723_abnormal_immune_serum1.62124854
53MP0005464_abnormal_platelet_physiology1.62013005
54MP0003763_abnormal_thymus_physiology1.61485242
55MP0003221_abnormal_cardiomyocyte_apopto1.58423964
56MP0005319_abnormal_enzyme/_coenzyme1.57857788
57MP0005000_abnormal_immune_tolerance1.56631710
58MP0001853_heart_inflammation1.56277501
59MP0002398_abnormal_bone_marrow1.50908490
60MP0008058_abnormal_DNA_repair1.50282101
61MP0004957_abnormal_blastocyst_morpholog1.50263746
62MP0006082_CNS_inflammation1.50198243
63MP0000689_abnormal_spleen_morphology1.49349772
64MP0005332_abnormal_amino_acid1.48928805
65MP0009333_abnormal_splenocyte_physiolog1.48744963
66MP0002452_abnormal_antigen_presenting1.48314854
67MP0001661_extended_life_span1.47991203
68MP0002419_abnormal_innate_immunity1.47313828
69MP0002132_abnormal_respiratory_system1.45352806
70MP0002420_abnormal_adaptive_immunity1.44144619
71MP0003718_maternal_effect1.43114884
72MP0001819_abnormal_immune_cell1.42325305
73MP0000609_abnormal_liver_physiology1.42156810
74MP0001790_abnormal_immune_system1.42133335
75MP0005387_immune_system_phenotype1.42133335
76MP0002006_tumorigenesis1.41898545
77MP0008057_abnormal_DNA_replication1.40860244
78MP0003252_abnormal_bile_duct1.40212396
79MP0002722_abnormal_immune_system1.35457926
80MP0000716_abnormal_immune_system1.34626890
81MP0004808_abnormal_hematopoietic_stem1.32615433
82MP0002127_abnormal_cardiovascular_syste1.32118148
83MP0009697_abnormal_copulation1.31421340
84MP0002429_abnormal_blood_cell1.30807238
85MP0005075_abnormal_melanosome_morpholog1.30269205
86MP0001529_abnormal_vocalization1.29887579
87MP0005584_abnormal_enzyme/coenzyme_acti1.28219083
88MP0005636_abnormal_mineral_homeostasis1.28193712
89MP0001845_abnormal_inflammatory_respons1.27614697
90MP0001666_abnormal_nutrient_absorption1.27573450
91MP0008877_abnormal_DNA_methylation1.24296074
92MP0004130_abnormal_muscle_cell1.23814600
93MP0003077_abnormal_cell_cycle1.22682988
94MP0000465_gastrointestinal_hemorrhage1.22448871
95MP0002138_abnormal_hepatobiliary_system1.20207964
96MP0002108_abnormal_muscle_morphology1.19854341
97MP0001544_abnormal_cardiovascular_syste1.19354555
98MP0005385_cardiovascular_system_phenoty1.19354555
99MP0008932_abnormal_embryonic_tissue1.17670189
100MP0005083_abnormal_biliary_tract1.17346922
101MP0010155_abnormal_intestine_physiology1.15398865
102MP0003137_abnormal_impulse_conducting1.15047088
103MP0009643_abnormal_urine_homeostasis1.14841271
104MP0009763_increased_sensitivity_to1.13302338
105MP0004484_altered_response_of1.09875469
106MP0000598_abnormal_liver_morphology1.08885563
107MP0002876_abnormal_thyroid_physiology1.08537035
108MP0000490_abnormal_crypts_of1.07840819
109MP0006035_abnormal_mitochondrial_morpho1.05926847
110MP0002019_abnormal_tumor_incidence1.04325980
111MP0009764_decreased_sensitivity_to1.01681663
112MP0008007_abnormal_cellular_replicative1.00626692
113MP0003646_muscle_fatigue1.00394308
114MP0003866_abnormal_defecation1.00152196
115MP0006292_abnormal_olfactory_placode0.99025878
116MP0003111_abnormal_nucleus_morphology0.98977459
117MP0003950_abnormal_plasma_membrane0.98901065
118MP0002118_abnormal_lipid_homeostasis0.98654804
119MP0002102_abnormal_ear_morphology0.98643228
120MP0004019_abnormal_vitamin_homeostasis0.97281312
121MP0005058_abnormal_lysosome_morphology0.96864567
122MP0006072_abnormal_retinal_apoptosis0.96710095
123MP0003011_delayed_dark_adaptation0.93580620
124MP0010630_abnormal_cardiac_muscle0.92067552
125MP0002095_abnormal_skin_pigmentation0.90324673
126MP0004185_abnormal_adipocyte_glucose0.90265545
127MP0005376_homeostasis/metabolism_phenot0.90022643
128MP0003567_abnormal_fetal_cardiomyocyte0.89341026
129MP0008775_abnormal_heart_ventricle0.88263641
130MP0003868_abnormal_feces_composition0.88147458
131MP0003195_calcinosis0.87388328
132MP0008995_early_reproductive_senescence0.87223788
133MP0009379_abnormal_foot_pigmentation0.86836315
134MP0002405_respiratory_system_inflammati0.85968704
135MP0000343_altered_response_to0.85529635
136MP0005266_abnormal_metabolism0.85246379
137MP0004782_abnormal_surfactant_physiolog0.85031405
138MP0005174_abnormal_tail_pigmentation0.83666796
139MP0004142_abnormal_muscle_tone0.83197111
140MP0005084_abnormal_gallbladder_morpholo0.81941843
141MP0003786_premature_aging0.81811501
142MP0002877_abnormal_melanocyte_morpholog0.81430428
143MP0009642_abnormal_blood_homeostasis0.80941090
144MP0001873_stomach_inflammation0.80640726
145MP0009765_abnormal_xenobiotic_induced0.79461783
146MP0002163_abnormal_gland_morphology0.78792586
147MP0005670_abnormal_white_adipose0.78537422
148MP0000733_abnormal_muscle_development0.78056409
149MP0005645_abnormal_hypothalamus_physiol0.76403189
150MP0002638_abnormal_pupillary_reflex0.72508681
151MP0000013_abnormal_adipose_tissue0.72380579
152MP0001929_abnormal_gametogenesis0.71607354
153MP0001730_embryonic_growth_arrest0.68401598
154MP0006138_congestive_heart_failure0.68307540
155MP0000358_abnormal_cell_content/0.65321032
156MP0001293_anophthalmia0.64658924
157MP0002971_abnormal_brown_adipose0.62988914
158MP0005253_abnormal_eye_physiology0.62045623
159MP0005666_abnormal_adipose_tissue0.61068375
160MP0000313_abnormal_cell_death0.60503735
161MP0002210_abnormal_sex_determination0.58249096
162MP0004085_abnormal_heartbeat0.55931986
163MP0001697_abnormal_embryo_size0.53994768
164MP0001727_abnormal_embryo_implantation0.53859146
165MP0002234_abnormal_pharynx_morphology0.53500316
166MP0000653_abnormal_sex_gland0.52490702
167MP0001145_abnormal_male_reproductive0.52295669
168MP0008789_abnormal_olfactory_epithelium0.49674665
169MP0005452_abnormal_adipose_tissue0.49134033
170MP0008872_abnormal_physiological_respon0.49027270
171MP0002078_abnormal_glucose_homeostasis0.48178688
172MP0000350_abnormal_cell_proliferation0.47204449
173MP0002822_catalepsy0.46863463
174MP0009672_abnormal_birth_weight0.46821827

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)8.76650834
2Muscle fiber inclusion bodies (HP:0100299)8.62502706
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.30983515
4Exercise-induced muscle cramps (HP:0003710)6.31262704
5Exercise-induced myalgia (HP:0003738)5.80816122
6Type 1 muscle fiber predominance (HP:0003803)5.18214795
7Muscle hypertrophy of the lower extremities (HP:0008968)4.75858998
8Distal arthrogryposis (HP:0005684)4.32253102
9Rhabdomyolysis (HP:0003201)4.26723251
10Calf muscle hypertrophy (HP:0008981)4.16767300
11Myoglobinuria (HP:0002913)4.04572255
12Aplastic anemia (HP:0001915)3.98470639
13EMG: myopathic abnormalities (HP:0003458)3.91929063
14Rimmed vacuoles (HP:0003805)3.86577090
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.85105100
16Myopathic facies (HP:0002058)3.83428006
17Abnormality of cells of the erythroid lineage (HP:0012130)3.72784283
18Abnormal number of erythroid precursors (HP:0012131)3.65855583
19Hepatic necrosis (HP:0002605)3.42678267
20Neck muscle weakness (HP:0000467)3.39469497
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.24974237
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.24974237
23Progressive macrocephaly (HP:0004481)3.21733043
24Thrombocytosis (HP:0001894)3.20615755
25Hepatocellular necrosis (HP:0001404)3.19410859
26Exercise intolerance (HP:0003546)3.15200353
27IgM deficiency (HP:0002850)3.11574871
28Abnormality of monocarboxylic acid metabolism (HP:0010996)3.10564120
29Muscle stiffness (HP:0003552)3.08698750
30Abnormality of the calf musculature (HP:0001430)3.07856669
31Hypobetalipoproteinemia (HP:0003563)3.06527568
32Generalized aminoaciduria (HP:0002909)2.99289605
33Muscle fiber splitting (HP:0003555)2.98058695
34Round ear (HP:0100830)2.97344955
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.94911014
36Absent phalangeal crease (HP:0006109)2.89684720
37Prolonged partial thromboplastin time (HP:0003645)2.85943196
38Areflexia of lower limbs (HP:0002522)2.85927704
39Calcaneovalgus deformity (HP:0001848)2.81164196
40Progressive muscle weakness (HP:0003323)2.81061010
41Ulnar deviation of the wrist (HP:0003049)2.80984491
42Abnormality of the left ventricular outflow tract (HP:0011103)2.80441680
43Subaortic stenosis (HP:0001682)2.80441680
44Hyperglycinemia (HP:0002154)2.76443354
45Hyporeflexia of lower limbs (HP:0002600)2.75705661
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.71392303
47Abnormality of fatty-acid metabolism (HP:0004359)2.70773225
48Myotonia (HP:0002486)2.70663801
49Reduced antithrombin III activity (HP:0001976)2.70239123
50Petechiae (HP:0000967)2.68800633
51Abnormality of skeletal muscle fiber size (HP:0012084)2.64176873
52Intrahepatic cholestasis (HP:0001406)2.63793162
53Hyperammonemia (HP:0001987)2.62981983
54Reticulocytopenia (HP:0001896)2.62244816
55Increased intramyocellular lipid droplets (HP:0012240)2.57238956
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55451054
57Dicarboxylic aciduria (HP:0003215)2.55451054
58Deformed tarsal bones (HP:0008119)2.53115781
59Vacuolated lymphocytes (HP:0001922)2.53044508
60Increased muscle lipid content (HP:0009058)2.52849223
61Abnormal finger flexion creases (HP:0006143)2.52104535
62Recurrent bronchitis (HP:0002837)2.50540567
63Macrocytic anemia (HP:0001972)2.48863188
64Chronic otitis media (HP:0000389)2.47205739
65Hypoglycemic coma (HP:0001325)2.46549954
66Hyperbilirubinemia (HP:0002904)2.46322304
67Ketosis (HP:0001946)2.44437074
68Increased serum lactate (HP:0002151)2.44386405
69Mitochondrial inheritance (HP:0001427)2.43145974
70Malignant hyperthermia (HP:0002047)2.42660979
71Elevated erythrocyte sedimentation rate (HP:0003565)2.42234562
72Abnormality of pyrimidine metabolism (HP:0004353)2.42091366
73Abnormality of glycine metabolism (HP:0010895)2.40446149
74Abnormality of serine family amino acid metabolism (HP:0010894)2.40446149
75Hypoplasia of the thymus (HP:0000778)2.39889034
76Increased CSF lactate (HP:0002490)2.39850778
77Lactic acidosis (HP:0003128)2.39567035
78Type 2 muscle fiber atrophy (HP:0003554)2.39116901
79Cerebral edema (HP:0002181)2.38443607
80Abnormality of serum amino acid levels (HP:0003112)2.36083525
81Lipid accumulation in hepatocytes (HP:0006561)2.36078470
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35402393
83Pallor (HP:0000980)2.33253459
84Increased serum pyruvate (HP:0003542)2.32446371
853-Methylglutaconic aciduria (HP:0003535)2.30656639
86Abnormal spermatogenesis (HP:0008669)2.29940120
87Joint hemorrhage (HP:0005261)2.29491687
88Abnormal mitochondria in muscle tissue (HP:0008316)2.28945789
89Increased hepatocellular lipid droplets (HP:0006565)2.28161843
90Pancytopenia (HP:0001876)2.27281127
91Abnormality of T cell physiology (HP:0011840)2.27150693
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27052553
93Hyperglycinuria (HP:0003108)2.26756296
94Xanthomatosis (HP:0000991)2.25615358
95Sudden death (HP:0001699)2.23920691
96Abnormality of the intrinsic pathway (HP:0010989)2.22087922
97Type I transferrin isoform profile (HP:0003642)2.21724854
98Microvesicular hepatic steatosis (HP:0001414)2.20601745
99Nasal polyposis (HP:0100582)2.20085509
100Acute encephalopathy (HP:0006846)2.18520203
101Respiratory failure (HP:0002878)2.16842374
102Weak cry (HP:0001612)2.16075669
103Difficulty running (HP:0009046)2.13941634
104Abnormality of the common coagulation pathway (HP:0010990)2.13523716
105Epistaxis (HP:0000421)2.11870862
106Frequent falls (HP:0002359)2.10756627
107Lethargy (HP:0001254)2.09490287
108Acute necrotizing encephalopathy (HP:0006965)2.08449305
109Myositis (HP:0100614)2.06882258
110Muscle fiber atrophy (HP:0100295)2.06300152
111Abnormality of alanine metabolism (HP:0010916)2.06167261
112Hyperalaninemia (HP:0003348)2.06167261
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06167261
114Abnormality of glycolysis (HP:0004366)2.04808615
115Dilated cardiomyopathy (HP:0001644)2.04795004
116Neutropenia (HP:0001875)2.03456300
117IgG deficiency (HP:0004315)2.02684194
118Fat malabsorption (HP:0002630)2.01983318
119Metabolic acidosis (HP:0001942)2.01925557
120Generalized muscle weakness (HP:0003324)1.99420317
121Hyperlipoproteinemia (HP:0010980)1.99376774
122Increased serum ferritin (HP:0003281)1.98038249
123Gout (HP:0001997)1.97183488
124EMG: neuropathic changes (HP:0003445)1.96232657
125Birth length less than 3rd percentile (HP:0003561)1.95822154
126Limb-girdle muscle atrophy (HP:0003797)1.94939288
127Oral leukoplakia (HP:0002745)1.94610034
128Renal Fanconi syndrome (HP:0001994)1.92670735
129Abnormality of the nasal mucosa (HP:0000433)1.91121804
130Nausea (HP:0002018)1.90819810
131Poikiloderma (HP:0001029)1.90286449
132Abnormality of nucleobase metabolism (HP:0010932)1.89977456
133Deep venous thrombosis (HP:0002625)1.89483623
134Abnormality of iron homeostasis (HP:0011031)1.88977595
135Bundle branch block (HP:0011710)1.88000275
136Abnormality of T cells (HP:0002843)1.87578397
137Abnormal platelet function (HP:0011869)1.86675234
138Impaired platelet aggregation (HP:0003540)1.86675234
139Palpitations (HP:0001962)1.85835763
140Abnormal protein glycosylation (HP:0012346)1.85271330
141Abnormal glycosylation (HP:0012345)1.85271330
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85271330
143Abnormal protein N-linked glycosylation (HP:0012347)1.85271330
144B lymphocytopenia (HP:0010976)1.85190017
145Abnormality of B cell number (HP:0010975)1.85190017
146Ragged-red muscle fibers (HP:0003200)1.84986319
147Azoospermia (HP:0000027)1.84348318
148Asymmetric septal hypertrophy (HP:0001670)1.82973839
149CNS demyelination (HP:0007305)1.80842571
150Methylmalonic acidemia (HP:0002912)1.80835797
151Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80050923
152Exertional dyspnea (HP:0002875)1.79634317
153Microretrognathia (HP:0000308)1.79603483
154Optic disc pallor (HP:0000543)1.79296961
155Paralysis (HP:0003470)1.78131287
156Pancreatic islet-cell hyperplasia (HP:0004510)1.72850913
157Facial diplegia (HP:0001349)1.72665425
158Increased variability in muscle fiber diameter (HP:0003557)1.72013381
159Shoulder girdle muscle weakness (HP:0003547)1.70872990
160Respiratory insufficiency due to muscle weakness (HP:0002747)1.70364824
161Distal lower limb muscle weakness (HP:0009053)1.67829876
162Colon cancer (HP:0003003)1.64129396
163Hyperinsulinemic hypoglycemia (HP:0000825)1.62622133
164Fetal akinesia sequence (HP:0001989)1.61196949
165Multiple enchondromatosis (HP:0005701)1.58541202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.24828301
2PHKG23.76460692
3PHKG13.76460692
4NME23.41534575
5WEE13.27337332
6VRK23.06970725
7BUB12.97921700
8BCKDK2.97515903
9EIF2AK12.93916746
10NEK12.93654719
11KIT2.85446998
12STK162.76084765
13MAP4K12.59138758
14TTN2.52252296
15MAP2K32.40562647
16FLT32.35555630
17EIF2AK32.30527720
18BRSK22.15105932
19ACVR1B2.07253575
20TEC1.91295361
21MAP4K21.90861600
22PIK3CG1.84200360
23BMPR1B1.83554086
24PINK11.80365380
25TBK11.79534555
26TYK21.76251277
27ZAK1.75616977
28VRK11.74707084
29BTK1.66488315
30NEK91.60537107
31RPS6KA41.59002080
32NUAK11.51708254
33TTK1.50762288
34TSSK61.48481539
35PLK31.46353918
36SRPK11.42606246
37CSF1R1.41121476
38IRAK41.40284205
39IRAK31.39728781
40PKN21.37286084
41ERN11.35563711
42KDR1.30363629
43IKBKE1.28405584
44PDK31.24330304
45PDK41.24330304
46CDC71.24263164
47NEK21.24017975
48MAP3K141.23465074
49TRIM281.23383937
50NME11.22163496
51SYK1.18741169
52PIM21.16110721
53JAK31.15850953
54ZAP701.15617385
55TXK1.14488938
56PASK1.11451314
57MAPK111.11196994
58CCNB11.07882635
59MAP3K31.07287270
60RPS6KB21.02618596
61DYRK31.02220571
62TAOK31.01755919
63MAP2K61.01430848
64CDK81.01331786
65WNK30.98652138
66TESK20.97681978
67FGFR40.97275559
68ERBB30.96853386
69IKBKB0.91102376
70BLK0.90794952
71ATR0.90634928
72LYN0.88711598
73PBK0.87807367
74BRSK10.87651017
75PDK20.87189289
76TAF10.85026835
77CDK40.84570433
78MATK0.81345851
79MAP3K60.80993705
80MKNK20.76654543
81MYLK0.74782682
82MAPKAPK30.72466075
83EEF2K0.71849174
84MAP3K110.70060777
85TGFBR10.69403835
86TLK10.67772681
87GRK60.65884406
88MAPK120.64541083
89AURKB0.63932734
90MAP3K120.63565901
91PIM10.63313954
92TIE10.63190133
93PLK40.60091585
94EIF2AK20.59868724
95NLK0.59013160
96LRRK20.58008064
97MAP2K40.57723241
98ABL20.56260177
99CDK70.55994467
100TGFBR20.55860152
101CSNK1G10.54910953
102LCK0.54287658
103GRK10.53152261
104LIMK10.51959358
105PLK10.51148376
106MST40.50596873
107CSNK2A10.50445505
108AKT20.50264629
109DAPK10.50097179
110ADRBK20.49080420
111CSNK2A20.48818620
112CAMKK20.47856227
113CSNK1G30.47641956
114CDK190.47014298
115CHEK20.45710447
116JAK10.45274326
117MUSK0.44976366
118ITK0.44697610
119MAP3K50.44296903
120MAP3K70.43049311
121ATM0.42654104
122PRKG20.42348028
123SCYL20.41960806
124AURKA0.41049024
125TNIK0.41018095
126MKNK10.39710742
127JAK20.38884285
128STK40.38284256
129DYRK1B0.38097305
130PAK40.36983332
131BCR0.34078095
132CAMK2G0.33137350
133CHEK10.30387447
134PRKAA10.28000604
135PRKG10.27798062
136PLK20.27765793
137CDK90.27561085
138CSNK1G20.26955681
139MAP2K70.26866675
140PRKACB0.26821281
141DYRK20.24950111
142PRKDC0.24651216
143CAMK2A0.24212122
144PRKACA0.24088943
145OXSR10.23804963
146STK100.23539352
147RPS6KB10.23145621
148CAMK2D0.23024899
149PRKAA20.22823064
150PRKCQ0.22268032
151INSRR0.21132237

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.02363205
2DNA replication_Homo sapiens_hsa030302.97039171
3Caffeine metabolism_Homo sapiens_hsa002322.46648732
4Proteasome_Homo sapiens_hsa030502.44696059
5Cardiac muscle contraction_Homo sapiens_hsa042602.44651700
6Mismatch repair_Homo sapiens_hsa034302.16544556
7Alzheimers disease_Homo sapiens_hsa050102.07827515
8Drug metabolism - other enzymes_Homo sapiens_hsa009832.06890841
9Pyrimidine metabolism_Homo sapiens_hsa002402.04893362
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.04794268
11Folate biosynthesis_Homo sapiens_hsa007902.01479182
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95906419
13One carbon pool by folate_Homo sapiens_hsa006701.91631482
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.91172232
15RNA polymerase_Homo sapiens_hsa030201.90077308
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76355590
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74036877
18Selenocompound metabolism_Homo sapiens_hsa004501.67085147
19Homologous recombination_Homo sapiens_hsa034401.64391248
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.63895351
21Sulfur relay system_Homo sapiens_hsa041221.60388385
22Pentose phosphate pathway_Homo sapiens_hsa000301.60289487
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.59545022
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57108068
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55395556
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52755174
27Base excision repair_Homo sapiens_hsa034101.50105488
28Nucleotide excision repair_Homo sapiens_hsa034201.50105302
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.48791122
30Protein export_Homo sapiens_hsa030601.45416232
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45110094
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45006335
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44986153
34Peroxisome_Homo sapiens_hsa041461.44572231
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44544220
36Fatty acid degradation_Homo sapiens_hsa000711.36656773
37Vitamin B6 metabolism_Homo sapiens_hsa007501.36270456
38Sulfur metabolism_Homo sapiens_hsa009201.33162578
39Tryptophan metabolism_Homo sapiens_hsa003801.33080060
40Chemical carcinogenesis_Homo sapiens_hsa052041.28767383
41Primary immunodeficiency_Homo sapiens_hsa053401.28088030
42Biosynthesis of amino acids_Homo sapiens_hsa012301.27495534
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24907663
44Propanoate metabolism_Homo sapiens_hsa006401.23822004
45Carbon metabolism_Homo sapiens_hsa012001.23794563
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20728810
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20589423
48Antigen processing and presentation_Homo sapiens_hsa046121.20272478
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19513779
50Staphylococcus aureus infection_Homo sapiens_hsa051501.13997491
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13412372
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07656896
53Pyruvate metabolism_Homo sapiens_hsa006201.06539469
54Histidine metabolism_Homo sapiens_hsa003401.05495805
55Arginine biosynthesis_Homo sapiens_hsa002201.03043607
56Complement and coagulation cascades_Homo sapiens_hsa046101.02451991
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.99933929
58Spliceosome_Homo sapiens_hsa030400.99793780
59Purine metabolism_Homo sapiens_hsa002300.99360719
60Circadian rhythm_Homo sapiens_hsa047100.94932791
61beta-Alanine metabolism_Homo sapiens_hsa004100.94810160
62Glutathione metabolism_Homo sapiens_hsa004800.90240967
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89556458
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.88991871
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85446227
66Oxidative phosphorylation_Homo sapiens_hsa001900.85250335
67Parkinsons disease_Homo sapiens_hsa050120.83373635
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81673854
69Legionellosis_Homo sapiens_hsa051340.81194108
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.81015622
71Non-homologous end-joining_Homo sapiens_hsa034500.78479173
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78393976
73Starch and sucrose metabolism_Homo sapiens_hsa005000.78053780
74RNA transport_Homo sapiens_hsa030130.77806045
75Fructose and mannose metabolism_Homo sapiens_hsa000510.76299608
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75434161
77Dilated cardiomyopathy_Homo sapiens_hsa054140.75279497
78ABC transporters_Homo sapiens_hsa020100.75220656
79Nitrogen metabolism_Homo sapiens_hsa009100.74182033
80Oocyte meiosis_Homo sapiens_hsa041140.73772322
81Herpes simplex infection_Homo sapiens_hsa051680.72901303
82Galactose metabolism_Homo sapiens_hsa000520.71174022
83RNA degradation_Homo sapiens_hsa030180.70503599
84Metabolic pathways_Homo sapiens_hsa011000.70442924
85Butanoate metabolism_Homo sapiens_hsa006500.69761781
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68887392
87Arginine and proline metabolism_Homo sapiens_hsa003300.67961919
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.67706983
89Basal transcription factors_Homo sapiens_hsa030220.67351410
90Retinol metabolism_Homo sapiens_hsa008300.64918425
91Fanconi anemia pathway_Homo sapiens_hsa034600.64239411
92Measles_Homo sapiens_hsa051620.62349928
93Other glycan degradation_Homo sapiens_hsa005110.58902883
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57335031
95Phenylalanine metabolism_Homo sapiens_hsa003600.57298035
96Glucagon signaling pathway_Homo sapiens_hsa049220.57219382
97Cell cycle_Homo sapiens_hsa041100.54600079
98Huntingtons disease_Homo sapiens_hsa050160.53337628
99Fatty acid elongation_Homo sapiens_hsa000620.52273441
100PPAR signaling pathway_Homo sapiens_hsa033200.50961858
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50813830
102Regulation of autophagy_Homo sapiens_hsa041400.49565453
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48852991
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.48124665
105mRNA surveillance pathway_Homo sapiens_hsa030150.47147566
106Fatty acid metabolism_Homo sapiens_hsa012120.46916602
107Leishmaniasis_Homo sapiens_hsa051400.46553525
108N-Glycan biosynthesis_Homo sapiens_hsa005100.45915538
109Epstein-Barr virus infection_Homo sapiens_hsa051690.44430008
110Tyrosine metabolism_Homo sapiens_hsa003500.42750201
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42747934
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40857914
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39139977
114Phototransduction_Homo sapiens_hsa047440.37213809
115Olfactory transduction_Homo sapiens_hsa047400.29857251
116Calcium signaling pathway_Homo sapiens_hsa040200.27932179
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25607186
118p53 signaling pathway_Homo sapiens_hsa041150.22752911
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16727105
120Insulin signaling pathway_Homo sapiens_hsa049100.14041255
121Asthma_Homo sapiens_hsa053100.11080668
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10708950
123Viral myocarditis_Homo sapiens_hsa054160.09793533
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05994495
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04687891

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