CUTA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.25486584
2ribosomal small subunit assembly (GO:0000028)6.37464461
3establishment of protein localization to mitochondrial membrane (GO:0090151)6.06527816
4viral transcription (GO:0019083)5.61272944
5ribosomal small subunit biogenesis (GO:0042274)5.53087262
6translational termination (GO:0006415)5.38667311
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.24573944
8cotranslational protein targeting to membrane (GO:0006613)5.16727982
9protein targeting to ER (GO:0045047)5.12574095
10proteasome assembly (GO:0043248)4.96038454
11protein localization to endoplasmic reticulum (GO:0070972)4.92150814
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.86508620
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.85027139
14translational elongation (GO:0006414)4.84216767
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.65986991
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62820888
17ATP synthesis coupled proton transport (GO:0015986)4.62820888
18telomere maintenance via semi-conservative replication (GO:0032201)4.50075373
19maturation of SSU-rRNA (GO:0030490)4.44178602
20viral life cycle (GO:0019058)4.29586410
21translational initiation (GO:0006413)4.20250488
22translation (GO:0006412)4.19413594
23cellular protein complex disassembly (GO:0043624)4.15855521
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15795725
25ATP biosynthetic process (GO:0006754)4.14356347
26DNA strand elongation involved in DNA replication (GO:0006271)4.05586560
27respiratory electron transport chain (GO:0022904)4.01537688
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.01445023
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.01445023
30NADH dehydrogenase complex assembly (GO:0010257)4.01445023
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.99588138
32hydrogen ion transmembrane transport (GO:1902600)3.96317375
33purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.93713394
34purine nucleoside triphosphate biosynthetic process (GO:0009145)3.91737075
35electron transport chain (GO:0022900)3.91622799
36inner mitochondrial membrane organization (GO:0007007)3.89756544
37DNA strand elongation (GO:0022616)3.87118627
38oxidative phosphorylation (GO:0006119)3.83063338
39telomere maintenance via recombination (GO:0000722)3.82718238
40protein complex biogenesis (GO:0070271)3.80650871
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.72247765
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.71101927
43termination of RNA polymerase III transcription (GO:0006386)3.71101927
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70811494
45ribosomal large subunit biogenesis (GO:0042273)3.62633929
46formation of translation preinitiation complex (GO:0001731)3.60345538
47sequestering of actin monomers (GO:0042989)3.59315935
48ribonucleoside triphosphate biosynthetic process (GO:0009201)3.58902217
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.56529218
50mitochondrial respiratory chain complex assembly (GO:0033108)3.55271657
51protein complex disassembly (GO:0043241)3.51888536
52pseudouridine synthesis (GO:0001522)3.51442475
53proton transport (GO:0015992)3.51087179
54GDP-mannose metabolic process (GO:0019673)3.50110158
55respiratory chain complex IV assembly (GO:0008535)3.49145313
56protein localization to mitochondrion (GO:0070585)3.45043925
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45035376
58hydrogen transport (GO:0006818)3.43940901
59chaperone-mediated protein transport (GO:0072321)3.41472753
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.41362865
61GTP biosynthetic process (GO:0006183)3.40318464
62negative regulation of ligase activity (GO:0051352)3.39602403
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39602403
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.38684023
65signal peptide processing (GO:0006465)3.38671726
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36595753
67macromolecular complex disassembly (GO:0032984)3.34279925
68guanosine-containing compound biosynthetic process (GO:1901070)3.33976008
69ribonucleoprotein complex biogenesis (GO:0022613)3.33906069
70regulation of cellular amino acid metabolic process (GO:0006521)3.33850956
71protein targeting to membrane (GO:0006612)3.33754742
727-methylguanosine mRNA capping (GO:0006370)3.32549931
73protein targeting to mitochondrion (GO:0006626)3.31714510
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31251167
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31251167
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29571732
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29571732
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29571732
797-methylguanosine RNA capping (GO:0009452)3.28814196
80RNA capping (GO:0036260)3.28814196
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27770306
82cellular component biogenesis (GO:0044085)3.26471212
83deoxyribose phosphate biosynthetic process (GO:0046385)3.25915591
842-deoxyribonucleotide biosynthetic process (GO:0009265)3.25915591
85pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.24439653
86regulation of mitochondrial translation (GO:0070129)3.24233052
87telomere maintenance via telomere lengthening (GO:0010833)3.23812934
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23427662
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23427662
90intracellular protein transmembrane import (GO:0044743)3.23309320
91nucleoside triphosphate biosynthetic process (GO:0009142)3.22356288
92mitotic recombination (GO:0006312)3.22187874
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21627850
94mRNA catabolic process (GO:0006402)3.21166432
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20564909
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.19454984
97peptidyl-histidine modification (GO:0018202)3.18462735
98signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17151088
99signal transduction involved in DNA damage checkpoint (GO:0072422)3.17151088
100establishment of protein localization to mitochondrion (GO:0072655)3.16643506
101rRNA processing (GO:0006364)3.15005659
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14177747
103DNA replication checkpoint (GO:0000076)3.13628733
104DNA replication initiation (GO:0006270)3.13508608
105signal transduction involved in cell cycle checkpoint (GO:0072395)3.12573943
106iron-sulfur cluster assembly (GO:0016226)3.10623725
107metallo-sulfur cluster assembly (GO:0031163)3.10623725
108transcription-coupled nucleotide-excision repair (GO:0006283)3.10395103
109mitochondrial transport (GO:0006839)3.09507822
110rRNA modification (GO:0000154)3.08938559
111cytochrome complex assembly (GO:0017004)3.08635396
112pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.08161859
113establishment of integrated proviral latency (GO:0075713)3.06230013
114protein deneddylation (GO:0000338)3.05500434
115establishment of protein localization to membrane (GO:0090150)3.05060015
116protein neddylation (GO:0045116)3.04061239
117UTP biosynthetic process (GO:0006228)3.03588202
118nucleobase-containing small molecule interconversion (GO:0015949)3.03464250
119nuclear-transcribed mRNA catabolic process (GO:0000956)3.03318146
120protein-cofactor linkage (GO:0018065)3.03226058
121cullin deneddylation (GO:0010388)3.03028730
122protein targeting (GO:0006605)3.02993596
123establishment of viral latency (GO:0019043)3.00426227
124DNA damage response, detection of DNA damage (GO:0042769)2.89528629
125purine nucleoside monophosphate biosynthetic process (GO:0009127)2.89042386
126purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.89042386
127RNA catabolic process (GO:0006401)2.88304676
128aldehyde catabolic process (GO:0046185)2.84394556
129spliceosomal snRNP assembly (GO:0000387)2.81943916
130protein maturation by protein folding (GO:0022417)2.81910772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.20865437
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.17536790
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.92117151
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.86557890
5E2F7_22180533_ChIP-Seq_HELA_Human3.84949462
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83965205
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.82724041
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.55206437
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37549423
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.29281981
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11930696
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06484979
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81535513
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72200010
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55978540
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50956491
17* VDR_23849224_ChIP-Seq_CD4+_Human2.46374558
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45372403
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.44044615
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39440260
21XRN2_22483619_ChIP-Seq_HELA_Human2.36928943
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36275575
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.33499179
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30831535
25DCP1A_22483619_ChIP-Seq_HELA_Human2.25719620
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24855140
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14451532
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10129599
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09930596
30GABP_19822575_ChIP-Seq_HepG2_Human2.05924084
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.03506942
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.01253725
33* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01142585
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.99506532
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96255814
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94314686
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91663022
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81945970
39TTF2_22483619_ChIP-Seq_HELA_Human1.81608422
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80801717
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.74791105
42ELK1_19687146_ChIP-ChIP_HELA_Human1.64162733
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58390198
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53144920
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53034515
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49258068
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47855012
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41259403
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41016384
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.38870213
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37642426
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36468768
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36291614
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35756149
55VDR_21846776_ChIP-Seq_THP-1_Human1.34924114
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34394054
57EZH2_22144423_ChIP-Seq_EOC_Human1.34370445
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34337973
59* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33802020
60SPI1_23547873_ChIP-Seq_NB4_Human1.33309596
61CIITA_25753668_ChIP-Seq_RAJI_Human1.28899206
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28893462
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28683578
64* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26630307
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24849084
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20276988
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18775430
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.18061056
69ZNF274_21170338_ChIP-Seq_K562_Hela1.17436750
70* FOXP1_21924763_ChIP-Seq_HESCs_Human1.17263924
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16772619
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.16505442
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.14281935
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13704881
75CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13173589
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12965326
77VDR_22108803_ChIP-Seq_LS180_Human1.11784146
78* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10279756
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09983774
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09303521
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08348194
82* TFEB_21752829_ChIP-Seq_HELA_Human1.07982312
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07866850
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07660990
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06862110
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06523639
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05985253
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05572774
89KDM5A_27292631_Chip-Seq_BREAST_Human1.02796019
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02200577
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02027346
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99676165
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99605056
94MYC_18940864_ChIP-ChIP_HL60_Human0.98130559
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97769490
96* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97562254
97E2F1_21310950_ChIP-Seq_MCF-7_Human0.97250351
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96640931
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96542487
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95507815
101PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95330687
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94132855
103EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93798704
104* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92811849
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92708742
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92560763
107TET1_21451524_ChIP-Seq_MESCs_Mouse0.92351248
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92161005
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90689140
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90475927
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89178367
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89113083
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87628685
114IRF1_19129219_ChIP-ChIP_H3396_Human0.87535661
115YY1_22570637_ChIP-Seq_MALME-3M_Human0.86810855
116MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86464348
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86284472
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86091304
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85944339
120* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85626795
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85391967
122CBX2_27304074_Chip-Seq_ESCs_Mouse0.85167115
123CTCF_26484167_Chip-Seq_Bcells_Mouse0.85121460
124NANOG_16153702_ChIP-ChIP_HESCs_Human0.84868184
125BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82752845
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.80971622
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80701678
128RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79355920
129PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79164753
130TP53_22573176_ChIP-Seq_HFKS_Human0.76578022
131ERG_20517297_ChIP-Seq_VCAP_Human0.76483582
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74963242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.39141363
2MP0003186_abnormal_redox_activity3.22907484
3MP0009379_abnormal_foot_pigmentation3.19671278
4MP0004957_abnormal_blastocyst_morpholog2.99835691
5MP0008789_abnormal_olfactory_epithelium2.65692908
6MP0003806_abnormal_nucleotide_metabolis2.60360698
7MP0006036_abnormal_mitochondrial_physio2.53543157
8MP0001986_abnormal_taste_sensitivity2.41113234
9MP0003123_paternal_imprinting2.39832046
10MP0009333_abnormal_splenocyte_physiolog2.38785549
11MP0002396_abnormal_hematopoietic_system2.32808206
12MP0002102_abnormal_ear_morphology2.31262947
13MP0008057_abnormal_DNA_replication2.25307148
14MP0002653_abnormal_ependyma_morphology2.23014671
15MP0010094_abnormal_chromosome_stability2.20860119
16MP0005499_abnormal_olfactory_system2.15966594
17MP0005394_taste/olfaction_phenotype2.15966594
18MP0003122_maternal_imprinting2.12374123
19MP0003077_abnormal_cell_cycle2.10606548
20MP0003880_abnormal_central_pattern2.08965392
21MP0008058_abnormal_DNA_repair2.08916114
22MP0002132_abnormal_respiratory_system2.03433966
23MP0009785_altered_susceptibility_to2.02769779
24MP0003183_abnormal_peptide_metabolism1.97971616
25MP0008932_abnormal_embryonic_tissue1.97455650
26MP0006276_abnormal_autonomic_nervous1.95376927
27MP0005075_abnormal_melanosome_morpholog1.95179122
28MP0004147_increased_porphyrin_level1.94143736
29MP0001835_abnormal_antigen_presentation1.94041869
30MP0005671_abnormal_response_to1.90728735
31MP0002822_catalepsy1.88064656
32MP0006072_abnormal_retinal_apoptosis1.87991542
33MP0003121_genomic_imprinting1.83241511
34MP0002148_abnormal_hypersensitivity_rea1.82405943
35MP0003111_abnormal_nucleus_morphology1.82148407
36MP0003011_delayed_dark_adaptation1.78737336
37MP0003787_abnormal_imprinting1.77098034
38MP0000372_irregular_coat_pigmentation1.76654101
39MP0008995_early_reproductive_senescence1.76357859
40MP0002163_abnormal_gland_morphology1.76029579
41MP0001293_anophthalmia1.74864722
42MP0005058_abnormal_lysosome_morphology1.72474046
43MP0006054_spinal_hemorrhage1.68398395
44MP0000490_abnormal_crypts_of1.67744422
45MP0008007_abnormal_cellular_replicative1.65997391
46MP0003656_abnormal_erythrocyte_physiolo1.64533342
47MP0003763_abnormal_thymus_physiology1.63626729
48MP0004133_heterotaxia1.55802673
49MP0005025_abnormal_response_to1.53947270
50MP0001853_heart_inflammation1.53352379
51MP0003786_premature_aging1.51473956
52MP0002837_dystrophic_cardiac_calcinosis1.46904311
53MP0001984_abnormal_olfaction1.45323046
54MP0008877_abnormal_DNA_methylation1.45147528
55MP0001545_abnormal_hematopoietic_system1.44901897
56MP0005397_hematopoietic_system_phenotyp1.44901897
57MP0003315_abnormal_perineum_morphology1.43120146
58MP0005000_abnormal_immune_tolerance1.41569856
59MP0003724_increased_susceptibility_to1.40241635
60MP0005379_endocrine/exocrine_gland_phen1.39890692
61MP0002405_respiratory_system_inflammati1.39283497
62MP0000685_abnormal_immune_system1.38249208
63MP0003718_maternal_effect1.36572448
64MP0002736_abnormal_nociception_after1.36478454
65MP0003436_decreased_susceptibility_to1.35658906
66MP0003136_yellow_coat_color1.35131539
67MP0006035_abnormal_mitochondrial_morpho1.34569236
68MP0002398_abnormal_bone_marrow1.34023905
69MP0000343_altered_response_to1.33110934
70MP0002420_abnormal_adaptive_immunity1.30561939
71MP0002638_abnormal_pupillary_reflex1.30133736
72MP0002419_abnormal_innate_immunity1.30101040
73MP0003283_abnormal_digestive_organ1.29905931
74MP0001819_abnormal_immune_cell1.28862922
75MP0000689_abnormal_spleen_morphology1.28514800
76MP0002723_abnormal_immune_serum1.25608463
77MP0001764_abnormal_homeostasis1.24989512
78MP0001529_abnormal_vocalization1.24939787
79MP0000049_abnormal_middle_ear1.24831861
80MP0002722_abnormal_immune_system1.23669308
81MP0006082_CNS_inflammation1.23486433
82MP0005174_abnormal_tail_pigmentation1.23110867
83MP0009046_muscle_twitch1.22788368
84MP0002429_abnormal_blood_cell1.22719659
85MP0000631_abnormal_neuroendocrine_gland1.22646574
86MP0005084_abnormal_gallbladder_morpholo1.22484441
87MP0000778_abnormal_nervous_system1.22468056
88MP0002452_abnormal_antigen_presenting1.19211796
89MP0001968_abnormal_touch/_nociception1.18205956
90MP0000716_abnormal_immune_system1.18133000
91MP0005551_abnormal_eye_electrophysiolog1.17298013
92MP0002019_abnormal_tumor_incidence1.16292489
93MP0002234_abnormal_pharynx_morphology1.16162825
94MP0002938_white_spotting1.15517404
95MP0002272_abnormal_nervous_system1.14279347
96MP0005423_abnormal_somatic_nervous1.14126416
97MP0000313_abnormal_cell_death1.13237677
98MP0008469_abnormal_protein_level1.11969276
99MP0005645_abnormal_hypothalamus_physiol1.11397104
100MP0002557_abnormal_social/conspecific_i1.09981142
101MP0001800_abnormal_humoral_immune1.09759843
102MP0005636_abnormal_mineral_homeostasis1.08759740
103MP0005646_abnormal_pituitary_gland1.07804942
104MP0000358_abnormal_cell_content/1.07713529
105MP0000858_altered_metastatic_potential1.07627940
106MP0002734_abnormal_mechanical_nocicepti1.05615321
107MP0001485_abnormal_pinna_reflex1.05431343
108MP0002751_abnormal_autonomic_nervous1.05322218
109MP0005408_hypopigmentation1.04105721
110MP0005253_abnormal_eye_physiology1.03899110
111MP0009840_abnormal_foam_cell1.03822511
112MP0000566_synostosis1.03013194
113MP0000026_abnormal_inner_ear1.02864130
114MP0005464_abnormal_platelet_physiology1.02813662
115MP0000750_abnormal_muscle_regeneration1.01756954
116MP0009697_abnormal_copulation1.01576473
117MP0002184_abnormal_innervation0.99946872
118MP0003938_abnormal_ear_development0.99926348
119MP0002752_abnormal_somatic_nervous0.99032593
120MP0005266_abnormal_metabolism0.99015602
121MP0008260_abnormal_autophagy0.98601102
122MP0001845_abnormal_inflammatory_respons0.97769575
123MP0009745_abnormal_behavioral_response0.97683109
124MP0000749_muscle_degeneration0.97329443
125MP0005171_absent_coat_pigmentation0.97289931
126MP0006292_abnormal_olfactory_placode0.96562970
127MP0001542_abnormal_bone_strength0.96492162
128MP0003646_muscle_fatigue0.96079923
129MP0002160_abnormal_reproductive_system0.95318081
130MP0000465_gastrointestinal_hemorrhage0.94376743
131MP0005332_abnormal_amino_acid0.91059135
132MP0001905_abnormal_dopamine_level0.89368612
133MP0003172_abnormal_lysosome_physiology0.89175130
134MP0005584_abnormal_enzyme/coenzyme_acti0.88130790
135MP0003942_abnormal_urinary_system0.86927300
136MP0009643_abnormal_urine_homeostasis0.86600723
137MP0002233_abnormal_nose_morphology0.86596223
138MP0005220_abnormal_exocrine_pancreas0.86500641
139MP0004145_abnormal_muscle_electrophysio0.86439976
140MP0002572_abnormal_emotion/affect_behav0.86423151
141MP0002277_abnormal_respiratory_mucosa0.85992270
142MP0005195_abnormal_posterior_eye0.85956903
143MP0004381_abnormal_hair_follicle0.85248967
144MP0002095_abnormal_skin_pigmentation0.85009304
145MP0005319_abnormal_enzyme/_coenzyme0.84399848
146MP0008875_abnormal_xenobiotic_pharmacok0.84147452
147MP0003866_abnormal_defecation0.84120908
148MP0001299_abnormal_eye_distance/0.83541953
149MP0000955_abnormal_spinal_cord0.83520637
150MP0004142_abnormal_muscle_tone0.83115420
151MP0004859_abnormal_synaptic_plasticity0.82655055
152MP0001873_stomach_inflammation0.81744245
153MP0002210_abnormal_sex_determination0.81419688
154MP0010030_abnormal_orbit_morphology0.80546295
155MP0001970_abnormal_pain_threshold0.80132224
156MP0002909_abnormal_adrenal_gland0.79633856
157MP0005387_immune_system_phenotype0.79454565
158MP0001790_abnormal_immune_system0.79454565
159MP0010386_abnormal_urinary_bladder0.79364104
160MP0005391_vision/eye_phenotype0.78922759
161MP0000703_abnormal_thymus_morphology0.78801536
162MP0002697_abnormal_eye_size0.78480814
163MP0002733_abnormal_thermal_nociception0.78294274
164MP0001188_hyperpigmentation0.77511977
165MP0005376_homeostasis/metabolism_phenot0.77480130
166MP0002090_abnormal_vision0.77174495
167MP0002064_seizures0.77066278
168MP0001286_abnormal_eye_development0.75972353
169MP0002882_abnormal_neuron_morphology0.75275627
170MP0001324_abnormal_eye_pigmentation0.74983611
171MP0005377_hearing/vestibular/ear_phenot0.74078014
172MP0000015_abnormal_ear_pigmentation0.71683165

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.10911418
2Abnormal number of erythroid precursors (HP:0012131)5.02511903
3Hepatocellular necrosis (HP:0001404)4.95397680
4Acute necrotizing encephalopathy (HP:0006965)4.94395458
5Mitochondrial inheritance (HP:0001427)4.89050306
6Hepatic necrosis (HP:0002605)4.65944053
7Abnormal mitochondria in muscle tissue (HP:0008316)4.61248256
8Increased CSF lactate (HP:0002490)4.30115416
9Acute encephalopathy (HP:0006846)4.16421177
10Reticulocytopenia (HP:0001896)4.09285314
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.85141223
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.85141223
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.81852432
14Increased hepatocellular lipid droplets (HP:0006565)3.81336502
15Progressive macrocephaly (HP:0004481)3.79941656
16Type I transferrin isoform profile (HP:0003642)3.65745297
17Lipid accumulation in hepatocytes (HP:0006561)3.63959237
183-Methylglutaconic aciduria (HP:0003535)3.62512865
19Renal Fanconi syndrome (HP:0001994)3.54605183
20Increased serum lactate (HP:0002151)3.43043100
21Exertional dyspnea (HP:0002875)3.40398808
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33101918
23Increased intramyocellular lipid droplets (HP:0012240)3.26347431
24Respiratory failure (HP:0002878)3.26101347
25Lactic acidosis (HP:0003128)3.23463589
26Myokymia (HP:0002411)3.23159166
27Macrocytic anemia (HP:0001972)3.21130340
28Abnormality of the heme biosynthetic pathway (HP:0010472)3.08659706
29Increased muscle lipid content (HP:0009058)3.00647534
30Exercise intolerance (HP:0003546)2.99714933
31Pallor (HP:0000980)2.96114656
32Aplastic anemia (HP:0001915)2.88389056
33Poor head control (HP:0002421)2.83059881
34Cerebral edema (HP:0002181)2.78076568
35Respiratory difficulties (HP:0002880)2.70087170
36Petechiae (HP:0000967)2.67758204
37Abnormal protein glycosylation (HP:0012346)2.65295784
38Abnormal glycosylation (HP:0012345)2.65295784
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.65295784
40Abnormal protein N-linked glycosylation (HP:0012347)2.65295784
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62281160
42Poor suck (HP:0002033)2.61163537
43Increased serum pyruvate (HP:0003542)2.59069232
44Abnormality of glycolysis (HP:0004366)2.59069232
45Reduced antithrombin III activity (HP:0001976)2.57914424
46Carpal bone hypoplasia (HP:0001498)2.54215641
47Pancreatic fibrosis (HP:0100732)2.48907871
48Cerebral hypomyelination (HP:0006808)2.46971767
49Leukodystrophy (HP:0002415)2.40362459
50CNS demyelination (HP:0007305)2.35517589
51Microvesicular hepatic steatosis (HP:0001414)2.29363977
52Oral leukoplakia (HP:0002745)2.21268732
53IgM deficiency (HP:0002850)2.20407477
54Optic disc pallor (HP:0000543)2.19810623
55Medial flaring of the eyebrow (HP:0010747)2.19105543
56Microretrognathia (HP:0000308)2.18934040
57Sclerocornea (HP:0000647)2.18760377
58Colon cancer (HP:0003003)2.14506019
59Molar tooth sign on MRI (HP:0002419)2.14212456
60Abnormality of midbrain morphology (HP:0002418)2.14212456
61Abnormality of renal resorption (HP:0011038)2.13604760
62Thrombocytosis (HP:0001894)2.12600145
63Septo-optic dysplasia (HP:0100842)2.12407846
64Elevated erythrocyte sedimentation rate (HP:0003565)2.12382187
65Generalized aminoaciduria (HP:0002909)2.10677788
66Congenital, generalized hypertrichosis (HP:0004540)2.09070929
67Rough bone trabeculation (HP:0100670)2.08630552
68Retinal dysplasia (HP:0007973)2.08490376
69Muscle fiber atrophy (HP:0100295)2.08479956
70Methylmalonic aciduria (HP:0012120)2.08151728
71Emotional lability (HP:0000712)2.07944102
72X-linked dominant inheritance (HP:0001423)2.06340380
73Vacuolated lymphocytes (HP:0001922)2.05456653
74Hyperglycinemia (HP:0002154)2.05346074
75Glycosuria (HP:0003076)2.04335637
76Abnormality of urine glucose concentration (HP:0011016)2.04335637
77Pancytopenia (HP:0001876)2.02858768
78Birth length less than 3rd percentile (HP:0003561)2.02436857
79Pancreatic cysts (HP:0001737)2.02146527
80Rib fusion (HP:0000902)2.01136433
81Recurrent abscess formation (HP:0002722)2.00578196
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98779391
83Abnormality of glycolipid metabolism (HP:0010969)1.96817416
84Abnormality of liposaccharide metabolism (HP:0010968)1.96817416
85Abnormality of glycosphingolipid metabolism (HP:0004343)1.96817416
86True hermaphroditism (HP:0010459)1.95652229
87Lethargy (HP:0001254)1.94076013
88Cerebral palsy (HP:0100021)1.93479302
89Type II lissencephaly (HP:0007260)1.92571238
90Methylmalonic acidemia (HP:0002912)1.92186657
91Dicarboxylic aciduria (HP:0003215)1.86990699
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86990699
93Purpura (HP:0000979)1.86388658
94Progressive muscle weakness (HP:0003323)1.86199814
95Nausea (HP:0002018)1.85827150
96Hypoplasia of the pons (HP:0012110)1.85145793
97Testicular atrophy (HP:0000029)1.84628207
98Dysostosis multiplex (HP:0000943)1.81827219
99Abnormality of the labia minora (HP:0012880)1.81571361
100Gait imbalance (HP:0002141)1.81523140
101Absent thumb (HP:0009777)1.81043406
102Adrenal hypoplasia (HP:0000835)1.80823721
103Hyperphosphaturia (HP:0003109)1.80157863
104Degeneration of anterior horn cells (HP:0002398)1.79741981
105Abnormality of the anterior horn cell (HP:0006802)1.79741981
106Increased serum ferritin (HP:0003281)1.78738806
107Type 2 muscle fiber atrophy (HP:0003554)1.78222542
108Spastic paraparesis (HP:0002313)1.77022761
109Congenital primary aphakia (HP:0007707)1.76856683
110Blindness (HP:0000618)1.76614199
111Sparse eyelashes (HP:0000653)1.75916186
112Progressive neurologic deterioration (HP:0002344)1.75505629
113Premature graying of hair (HP:0002216)1.73553558
114Amniotic constriction ring (HP:0009775)1.73430698
115Abnormality of placental membranes (HP:0011409)1.73430698
116Nephronophthisis (HP:0000090)1.73220896
117Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72091637
118Neutropenia (HP:0001875)1.71438718
119Anophthalmia (HP:0000528)1.69587382
120Abnormal urine phosphate concentration (HP:0012599)1.69503768
121Beaking of vertebral bodies (HP:0004568)1.68629666
122Abnormality of macrophages (HP:0004311)1.68063059
123Secondary amenorrhea (HP:0000869)1.65558671
124Nephrogenic diabetes insipidus (HP:0009806)1.65410880
125Pendular nystagmus (HP:0012043)1.64432532
126Opisthotonus (HP:0002179)1.63601250
127Abnormality of the pons (HP:0007361)1.62540420
128Abnormality of reticulocytes (HP:0004312)1.61861607
129Depressed nasal ridge (HP:0000457)1.61852718
130Multiple enchondromatosis (HP:0005701)1.61838114
131Death in infancy (HP:0001522)1.60449739
132Gliosis (HP:0002171)1.59167167
133Recurrent bacterial skin infections (HP:0005406)1.58967602
134Absent septum pellucidum (HP:0001331)1.57992006
135Megaloblastic anemia (HP:0001889)1.57537466
136Breast hypoplasia (HP:0003187)1.57328194
137Horseshoe kidney (HP:0000085)1.55950659
138Delayed CNS myelination (HP:0002188)1.54687546
139Myotonia (HP:0002486)1.54369150
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.52009866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.89814266
2NME24.80547866
3STK163.88802927
4PIM23.85063937
5BUB13.74571864
6WEE12.83991844
7ARAF2.43410546
8VRK12.40061920
9TLK12.36127694
10NME12.34025090
11BCKDK2.29612039
12TESK22.27513883
13EIF2AK32.23163911
14EIF2AK12.02409337
15KDR1.84417883
16MAP4K11.82429560
17MAP4K21.76920507
18IRAK31.72432934
19WNK31.64723740
20PBK1.60683527
21CDK191.57310609
22MAP3K111.53528333
23KIT1.51718876
24MAP2K71.50680663
25EPHB21.50153917
26NUAK11.49296193
27TAF11.49247062
28CDK81.48683706
29IRAK41.43282857
30CSNK1G31.39477146
31BLK1.30954693
32CSNK1G21.27478877
33MYLK1.27443864
34BRAF1.26359842
35DYRK31.25905439
36PLK41.25431291
37SRPK11.21645563
38ILK1.20037112
39ERN11.19194322
40LRRK21.17805226
41BRSK21.17541812
42CSNK1G11.17445902
43CCNB11.14513765
44PLK31.14322556
45TEC1.09845783
46MST41.07314832
47MAP3K121.04824120
48PRKCG1.02947002
49IRAK21.02669840
50CDK71.01692990
51GRK10.99722549
52TSSK60.99449725
53CDC70.97605450
54ABL20.97514741
55MAPKAPK50.96701519
56CSNK1A1L0.95960239
57CASK0.95160707
58AURKA0.91908239
59INSRR0.90884622
60MARK10.90629091
61NEK10.90478349
62MAPK150.88434981
63MUSK0.86146043
64TXK0.83705631
65ZAP700.82558580
66PLK10.80751173
67MINK10.78555242
68CSNK2A10.77577681
69RPS6KA40.77563799
70AURKB0.76115804
71PIM10.75979581
72RPS6KB20.75717087
73TRIM280.73713249
74MAPKAPK30.73645095
75ADRBK20.73213504
76BTK0.71443078
77FLT30.70582354
78TYK20.70520104
79MAP2K30.69823459
80TBK10.67204491
81NEK90.66709902
82TAOK30.64697784
83EPHA40.64428531
84CDK11A0.64327696
85RPS6KA50.64288632
86NLK0.62657877
87BRSK10.62409921
88SYK0.62218202
89CDK140.61654941
90GRK50.60374061
91PASK0.59271146
92TESK10.59118237
93MAP3K40.58983265
94PAK30.58707421
95IKBKB0.58648596
96CDK150.57730684
97RAF10.57722689
98RPS6KA60.56896257
99ATR0.56042911
100LYN0.56010380
101CDK180.55986408
102IRAK10.55918752
103DAPK10.55572937
104CSF1R0.55263964
105CSNK2A20.54245685
106ZAK0.53667869
107LIMK10.53592799
108PAK10.53360683
109MATK0.53117272
110CSNK1A10.51924007
111ACVR1B0.51500215
112PHKG10.50028236
113PHKG20.50028236
114CHEK20.48871401
115BMPR1B0.47872993
116PAK40.46711873
117PRKCI0.46438056
118CLK10.46309211
119TTK0.46056983
120PLK20.46056796
121NTRK20.44325383
122RPS6KL10.43834219
123RPS6KC10.43834219
124ADRBK10.43794342
125PDK20.43592153
126YES10.43361767
127DAPK30.42583451
128TNIK0.41483328
129PINK10.41397290
130MAPK130.41282792
131NEK20.40734763
132MAP3K30.40467972
133CSNK1E0.40134799
134NTRK30.38879584
135PRKACA0.38630978
136CAMK2D0.38610007
137CAMK2G0.38503989
138DYRK20.38497546
139MAPK40.38315098
140SIK30.37401916
141STK390.37398644
142MAP2K20.36681864
143PRKCD0.36539359
144UHMK10.36336660
145WNK40.34805034
146TIE10.32373321

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.10593282
2Proteasome_Homo sapiens_hsa030503.99024829
3DNA replication_Homo sapiens_hsa030303.85424395
4Oxidative phosphorylation_Homo sapiens_hsa001903.62454227
5RNA polymerase_Homo sapiens_hsa030203.28821149
6Parkinsons disease_Homo sapiens_hsa050123.20172772
7Protein export_Homo sapiens_hsa030603.14859897
8Mismatch repair_Homo sapiens_hsa034303.01885334
9Base excision repair_Homo sapiens_hsa034102.67990393
10Pyrimidine metabolism_Homo sapiens_hsa002402.54482220
11Homologous recombination_Homo sapiens_hsa034402.36531459
12Huntingtons disease_Homo sapiens_hsa050162.31213276
13Alzheimers disease_Homo sapiens_hsa050102.13369883
14Nucleotide excision repair_Homo sapiens_hsa034202.13056381
15Spliceosome_Homo sapiens_hsa030402.08347208
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07960716
17Folate biosynthesis_Homo sapiens_hsa007901.91318092
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89264806
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57095021
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56622868
21Sulfur relay system_Homo sapiens_hsa041221.49145225
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49070097
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47212285
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39541369
25Purine metabolism_Homo sapiens_hsa002301.32046434
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28972697
27RNA transport_Homo sapiens_hsa030131.28824895
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27810610
29Pentose phosphate pathway_Homo sapiens_hsa000301.14644514
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12267622
31RNA degradation_Homo sapiens_hsa030181.10374931
32Fanconi anemia pathway_Homo sapiens_hsa034601.07735307
33One carbon pool by folate_Homo sapiens_hsa006701.05964532
34Basal transcription factors_Homo sapiens_hsa030221.05596435
35Glutathione metabolism_Homo sapiens_hsa004801.04639714
36Fatty acid elongation_Homo sapiens_hsa000620.99039378
37Cell cycle_Homo sapiens_hsa041100.98173372
38Cardiac muscle contraction_Homo sapiens_hsa042600.95095000
39Non-homologous end-joining_Homo sapiens_hsa034500.94480438
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90191932
41Butanoate metabolism_Homo sapiens_hsa006500.90083472
42Metabolic pathways_Homo sapiens_hsa011000.81878542
43Arachidonic acid metabolism_Homo sapiens_hsa005900.80564659
44Carbon metabolism_Homo sapiens_hsa012000.78354909
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77842392
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.77636353
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75769973
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74845039
49Synaptic vesicle cycle_Homo sapiens_hsa047210.74841361
50Other glycan degradation_Homo sapiens_hsa005110.74433329
51Sulfur metabolism_Homo sapiens_hsa009200.73169048
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.73066075
53Biosynthesis of amino acids_Homo sapiens_hsa012300.70129042
54Phototransduction_Homo sapiens_hsa047440.70041954
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68494937
56Vitamin B6 metabolism_Homo sapiens_hsa007500.66928411
57N-Glycan biosynthesis_Homo sapiens_hsa005100.65689292
58Primary immunodeficiency_Homo sapiens_hsa053400.64221343
59p53 signaling pathway_Homo sapiens_hsa041150.63800546
60Galactose metabolism_Homo sapiens_hsa000520.61023976
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.60974004
62Lysosome_Homo sapiens_hsa041420.60312538
63Antigen processing and presentation_Homo sapiens_hsa046120.60077358
64Tyrosine metabolism_Homo sapiens_hsa003500.60020741
65Tryptophan metabolism_Homo sapiens_hsa003800.57404420
66Epstein-Barr virus infection_Homo sapiens_hsa051690.55450535
67Arginine and proline metabolism_Homo sapiens_hsa003300.55151539
68Basal cell carcinoma_Homo sapiens_hsa052170.54814516
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54403884
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.53304512
71Linoleic acid metabolism_Homo sapiens_hsa005910.53221904
72Asthma_Homo sapiens_hsa053100.51395781
73Fructose and mannose metabolism_Homo sapiens_hsa000510.51059374
74Nicotine addiction_Homo sapiens_hsa050330.50598930
75Pyruvate metabolism_Homo sapiens_hsa006200.49754448
76Regulation of autophagy_Homo sapiens_hsa041400.47944003
77Graft-versus-host disease_Homo sapiens_hsa053320.47213626
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46825110
79Peroxisome_Homo sapiens_hsa041460.46433115
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46370982
81Steroid biosynthesis_Homo sapiens_hsa001000.46308397
82Hematopoietic cell lineage_Homo sapiens_hsa046400.44594979
83Legionellosis_Homo sapiens_hsa051340.44095184
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43534624
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43344658
86Fatty acid metabolism_Homo sapiens_hsa012120.42646678
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.39869029
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38497793
89Herpes simplex infection_Homo sapiens_hsa051680.38280086
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.37023372
91Vibrio cholerae infection_Homo sapiens_hsa051100.36977608
92Fatty acid degradation_Homo sapiens_hsa000710.36247651
93Propanoate metabolism_Homo sapiens_hsa006400.35771693
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35374393
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34268649
96Collecting duct acid secretion_Homo sapiens_hsa049660.32800580
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32097254
98Hedgehog signaling pathway_Homo sapiens_hsa043400.31578091
99Retinol metabolism_Homo sapiens_hsa008300.30701838
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30451091
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.30385359
102Allograft rejection_Homo sapiens_hsa053300.30096522
103Phenylalanine metabolism_Homo sapiens_hsa003600.30041122
104Selenocompound metabolism_Homo sapiens_hsa004500.29436789
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27984040
106Rheumatoid arthritis_Homo sapiens_hsa053230.27257095
107Ether lipid metabolism_Homo sapiens_hsa005650.27156824
108Cocaine addiction_Homo sapiens_hsa050300.26485744
109Phagosome_Homo sapiens_hsa041450.26020302
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25823172
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25547177
112Chemical carcinogenesis_Homo sapiens_hsa052040.25507738
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25256589
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24316595
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.23760791
116Systemic lupus erythematosus_Homo sapiens_hsa053220.23075231
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22874949
118Insulin secretion_Homo sapiens_hsa049110.22173478
119beta-Alanine metabolism_Homo sapiens_hsa004100.22135976
120Vitamin digestion and absorption_Homo sapiens_hsa049770.21306843
121Nitrogen metabolism_Homo sapiens_hsa009100.21270192
122GABAergic synapse_Homo sapiens_hsa047270.21081837
123Histidine metabolism_Homo sapiens_hsa003400.20957985
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20844782
125Alcoholism_Homo sapiens_hsa050340.20338789
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16385794
127Leishmaniasis_Homo sapiens_hsa051400.16136619
128Caffeine metabolism_Homo sapiens_hsa002320.15772904

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