CUL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.36934026
2protein localization to synapse (GO:0035418)5.27638995
3dendritic spine morphogenesis (GO:0060997)5.27103381
4locomotory exploration behavior (GO:0035641)4.93705236
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.87877163
6negative regulation of erythrocyte differentiation (GO:0045647)4.82257900
7neuron cell-cell adhesion (GO:0007158)4.79928856
8mannose metabolic process (GO:0006013)4.70347762
9central nervous system myelination (GO:0022010)4.66159348
10axon ensheathment in central nervous system (GO:0032291)4.66159348
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62282009
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52365499
13synaptic vesicle exocytosis (GO:0016079)4.49761598
14exploration behavior (GO:0035640)4.42844791
15positive regulation of gamma-delta T cell activation (GO:0046645)4.37738630
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34585618
17synaptic vesicle maturation (GO:0016188)4.33565786
18neuronal action potential propagation (GO:0019227)4.16017033
19negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.10665480
20glutamate secretion (GO:0014047)3.97062647
21neuron recognition (GO:0008038)3.96595800
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.95654135
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90844955
24positive thymic T cell selection (GO:0045059)3.89028228
25regulation of synapse maturation (GO:0090128)3.84949556
26response to muramyl dipeptide (GO:0032495)3.81350139
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.80143367
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.78554854
29negative regulation of cell killing (GO:0031342)3.78554854
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.78187744
31glutamate receptor signaling pathway (GO:0007215)3.77080174
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.74045273
33thymic T cell selection (GO:0045061)3.71936241
34regulation of glutamate receptor signaling pathway (GO:1900449)3.68853110
35presynaptic membrane assembly (GO:0097105)3.68153682
36antigen processing and presentation of endogenous antigen (GO:0019883)3.68058835
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64745653
38regulation of gamma-delta T cell differentiation (GO:0045586)3.63982726
39transmission of nerve impulse (GO:0019226)3.63455274
40positive regulation of membrane potential (GO:0045838)3.62835925
41regulation of gamma-delta T cell activation (GO:0046643)3.57731518
42layer formation in cerebral cortex (GO:0021819)3.55241847
43regulation of ARF protein signal transduction (GO:0032012)3.54486113
44dendritic spine organization (GO:0097061)3.52134485
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.50735772
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50068534
47negative thymic T cell selection (GO:0045060)3.49330761
48regulation of vesicle fusion (GO:0031338)3.49024102
49presynaptic membrane organization (GO:0097090)3.47880860
50regulation of neuronal synaptic plasticity (GO:0048168)3.44737865
51regulation of synaptic vesicle exocytosis (GO:2000300)3.44484266
52positive regulation of dendritic spine development (GO:0060999)3.37956999
53T cell selection (GO:0045058)3.36776242
54axonal fasciculation (GO:0007413)3.34115905
55regulation of postsynaptic membrane potential (GO:0060078)3.30647517
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29649089
57negative T cell selection (GO:0043383)3.29385064
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28458967
59positive T cell selection (GO:0043368)3.26194887
60synaptic transmission, glutamatergic (GO:0035249)3.25130239
61long-term memory (GO:0007616)3.24119158
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.22530568
63histone H3-K36 demethylation (GO:0070544)3.21741855
64positive regulation of synapse assembly (GO:0051965)3.21304570
65regulation of ARF GTPase activity (GO:0032312)3.20843694
66neuron-neuron synaptic transmission (GO:0007270)3.17568812
67postsynaptic membrane organization (GO:0001941)3.17167222
68B cell receptor signaling pathway (GO:0050853)3.15809264
69regulation of bile acid biosynthetic process (GO:0070857)3.12634405
70neuronal ion channel clustering (GO:0045161)3.09074575
71regulation of voltage-gated calcium channel activity (GO:1901385)3.08170228
72germinal center formation (GO:0002467)3.07504883
73regulation of glutamate secretion (GO:0014048)3.07210667
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06987363
75regulation of axon extension (GO:0030516)3.06482483
76long-chain fatty acid biosynthetic process (GO:0042759)3.06218278
77regulation of synapse structural plasticity (GO:0051823)3.04664600
78neurotransmitter-gated ion channel clustering (GO:0072578)3.02335275
79negative regulation of protein localization to cell surface (GO:2000009)3.02302245
80neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.02279665
81regulation of synaptic vesicle transport (GO:1902803)3.01250562
82neurotransmitter secretion (GO:0007269)3.00519336
83positive regulation by symbiont of host defense response (GO:0052509)3.00100756
84modulation by symbiont of host defense response (GO:0052031)3.00100756
85modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00100756
86modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00100756
87positive regulation by organism of defense response of other organism involved in symbiotic interact3.00100756
88modulation by symbiont of host immune response (GO:0052553)3.00100756
89negative regulation of axon extension (GO:0030517)2.99461112
90behavioral response to cocaine (GO:0048148)2.98775736
91positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98591486
92membrane depolarization (GO:0051899)2.97144389
93regulation of B cell receptor signaling pathway (GO:0050855)2.97074086
94dendrite morphogenesis (GO:0048813)2.94166261
95long-term synaptic potentiation (GO:0060291)2.93749184
96detection of bacterium (GO:0016045)2.92567549
97macrophage activation involved in immune response (GO:0002281)2.92556334
98regulation of dendritic spine development (GO:0060998)2.92465348
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92342286
100detection of other organism (GO:0098543)2.89623734
101regulation of extent of cell growth (GO:0061387)2.88369240
102chaperone-mediated protein transport (GO:0072321)2.86075348
103regulation of dendritic spine morphogenesis (GO:0061001)2.85963496
104regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85506667
105negative regulation of neurotransmitter transport (GO:0051589)2.84770864
106detection of calcium ion (GO:0005513)2.84304328
107chemosensory behavior (GO:0007635)2.83251078
108membrane hyperpolarization (GO:0060081)2.82600933
109negative regulation of myotube differentiation (GO:0010832)2.82229037
110regulation of histone H3-K27 methylation (GO:0061085)2.81847182
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81788611
112membrane depolarization during action potential (GO:0086010)2.81517331
113learning (GO:0007612)2.81083775
114regulation of synaptic plasticity (GO:0048167)2.80333485
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78208759
116synapse organization (GO:0050808)2.78135406
117regulation of synapse organization (GO:0050807)2.78082899
118leukocyte aggregation (GO:0070486)2.77396626
119cellular potassium ion homeostasis (GO:0030007)2.77102736
120fear response (GO:0042596)2.74356658
121L-amino acid import (GO:0043092)2.74155579
122innervation (GO:0060384)2.73817326
123myelination (GO:0042552)2.73762661
124response to laminar fluid shear stress (GO:0034616)2.73398614
125synaptic vesicle endocytosis (GO:0048488)2.73162940
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.72764318
127gamma-aminobutyric acid transport (GO:0015812)2.72210573
128activation of JUN kinase activity (GO:0007257)2.72197173
129positive regulation of Rap GTPase activity (GO:0032854)2.71750932
130neurotransmitter transport (GO:0006836)2.71198380
131NIK/NF-kappaB signaling (GO:0038061)2.70733470
132adult walking behavior (GO:0007628)2.70258005
133neuron remodeling (GO:0016322)2.69835778
134positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.69199170
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68695690
136positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68250302
137regulation of neurotransmitter secretion (GO:0046928)2.68101655
138axon ensheathment (GO:0008366)2.67787712
139ensheathment of neurons (GO:0007272)2.67787712
140calcium ion-dependent exocytosis (GO:0017156)2.66025531
141regulation of dopamine metabolic process (GO:0042053)2.65725740
142regulation of catecholamine metabolic process (GO:0042069)2.65725740
143auditory behavior (GO:0031223)2.64898057
144regulation of synaptic transmission, glutamatergic (GO:0051966)2.64863961
145regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.63971949
146positive regulation of action potential (GO:0045760)2.63911278
147cellular extravasation (GO:0045123)2.63382587
148regulation of interferon-beta biosynthetic process (GO:0045357)2.63378831
149positive regulation of histone deacetylation (GO:0031065)2.62087783
150negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.60406841
151regulation of necroptotic process (GO:0060544)2.60327289
152response to peptidoglycan (GO:0032494)2.56393931
153histone H3-K4 trimethylation (GO:0080182)2.55707978
154histone H3-K9 demethylation (GO:0033169)2.54752525
155regulation of NFAT protein import into nucleus (GO:0051532)2.53265896
156histone lysine demethylation (GO:0070076)2.50169495
157T cell migration (GO:0072678)2.48798940
158detection of external biotic stimulus (GO:0098581)2.48296064
159signal complex assembly (GO:0007172)2.47826156
160embryonic process involved in female pregnancy (GO:0060136)2.47663053
161regulation of leukocyte degranulation (GO:0043300)2.46473821
162positive regulation of CREB transcription factor activity (GO:0032793)2.44542309
163negative regulation of lymphocyte mediated immunity (GO:0002707)2.43191053
164tolerance induction (GO:0002507)2.42749106
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.41873676
166histone demethylation (GO:0016577)2.40560928
167negative regulation of leukocyte mediated immunity (GO:0002704)2.40345426
168negative regulation of toll-like receptor signaling pathway (GO:0034122)2.40021080
169positive regulation of B cell differentiation (GO:0045579)2.39605797
170negative regulation of cell size (GO:0045792)2.39161673
171histone H4 deacetylation (GO:0070933)2.37586281
172positive regulation of granulocyte differentiation (GO:0030854)2.36843991
173response to interleukin-15 (GO:0070672)2.36686350
174semaphorin-plexin signaling pathway (GO:0071526)2.35380739
175modulation by virus of host process (GO:0019054)2.32954376
176positive regulation of protein deacetylation (GO:0090312)2.32315609
177modulation by symbiont of host cellular process (GO:0044068)2.31395767
178positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.31199537
179response to type I interferon (GO:0034340)2.29837401
180negative regulation of granulocyte differentiation (GO:0030853)2.29533614
181positive regulation of Cdc42 GTPase activity (GO:0043089)2.28821037
182activation of Rac GTPase activity (GO:0032863)2.28212009
183negative regulation of T cell mediated immunity (GO:0002710)2.25577533
184regulation of granulocyte differentiation (GO:0030852)2.24859069
185insulin-like growth factor receptor signaling pathway (GO:0048009)2.22649277
186cellular response to virus (GO:0098586)2.21997002
187regulation of Rap GTPase activity (GO:0032317)2.21444266
188cellular response to type I interferon (GO:0071357)2.20734914
189type I interferon signaling pathway (GO:0060337)2.20734914
190negative regulation of interleukin-8 production (GO:0032717)2.19916956
191negative regulation of fatty acid transport (GO:2000192)2.19830616
192regulation of extracellular matrix disassembly (GO:0010715)2.18213038
193negative regulation of innate immune response (GO:0045824)2.18213010
194cell-substrate adherens junction assembly (GO:0007045)2.18074873
195focal adhesion assembly (GO:0048041)2.18074873
196response to host (GO:0075136)2.17644925
197response to host defenses (GO:0052200)2.17644925
198response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.17644925
199detection of biotic stimulus (GO:0009595)2.16219039
200detection of molecule of bacterial origin (GO:0032490)2.15895389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.50584435
2GBX2_23144817_ChIP-Seq_PC3_Human3.59945625
3VDR_21846776_ChIP-Seq_THP-1_Human3.46819907
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10214899
5MYC_22102868_ChIP-Seq_BL_Human3.09365919
6KDM2B_26808549_Chip-Seq_SUP-B15_Human3.04209521
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99044571
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96565587
9LXR_22292898_ChIP-Seq_THP-1_Human2.77740944
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.70999958
11TCF7_22412390_ChIP-Seq_EML_Mouse2.66549822
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.61658099
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61322470
14KDM2B_26808549_Chip-Seq_DND41_Human2.58414315
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56854217
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56854217
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.54488582
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53206452
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49369091
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46706109
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44430882
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.43897657
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39560748
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.39435560
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38733702
26REST_21632747_ChIP-Seq_MESCs_Mouse2.33165890
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30900370
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28058610
29ELK3_25401928_ChIP-Seq_HUVEC_Human2.26243893
30VDR_24763502_ChIP-Seq_THP-1_Human2.26083981
31DROSHA_22980978_ChIP-Seq_HELA_Human2.25572067
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.24896558
33MAF_26560356_Chip-Seq_TH1_Human2.15603206
34TP63_17297297_ChIP-ChIP_HaCaT_Human2.13469963
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11277370
36RNF2_27304074_Chip-Seq_ESCs_Mouse2.11133676
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08364475
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05894713
39CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01492351
40CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00617785
41TAF15_26573619_Chip-Seq_HEK293_Human1.99924120
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97763832
43MAF_26560356_Chip-Seq_TH2_Human1.92487447
44RACK7_27058665_Chip-Seq_MCF-7_Human1.92239590
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92220646
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91900017
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.90417856
48UTX_26944678_Chip-Seq_JUKART_Human1.90082328
49KDM2B_26808549_Chip-Seq_K562_Human1.88403751
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.87913304
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.86219119
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85896183
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85269766
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81714552
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78195378
56SCL_19346495_ChIP-Seq_HPC-7_Human1.75663404
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73199598
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71192296
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70216299
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.67932714
61P68_20966046_ChIP-Seq_HELA_Human1.67538115
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66576886
63SMC4_20622854_ChIP-Seq_HELA_Human1.65490948
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.65115659
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63299890
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62767180
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.61687244
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59778324
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59396324
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.59181591
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.59024397
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56687904
73SPI1_23127762_ChIP-Seq_K562_Human1.55104944
74ZNF274_21170338_ChIP-Seq_K562_Hela1.54942545
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54908100
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.53953679
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53686124
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53450206
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52032027
80RUNX_20019798_ChIP-Seq_JUKART_Human1.51736824
81SMAD4_21799915_ChIP-Seq_A2780_Human1.50392278
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47379965
83P300_19829295_ChIP-Seq_ESCs_Human1.47325818
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46657277
85AR_21572438_ChIP-Seq_LNCaP_Human1.46263319
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46139218
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45995822
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.44140138
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.43447591
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43413971
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42693620
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.42616351
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41999044
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.39522750
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39323658
96CREB1_26743006_Chip-Seq_LNCaP_Human1.38199513
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.37640310
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37458022
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34620803
100* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33476560
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32090686
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30672579
103BCOR_27268052_Chip-Seq_Bcells_Human1.30464238
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.29073972
105* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28206587
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28068160
107MYB_26560356_Chip-Seq_TH1_Human1.26875930
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26724524
109FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26443724
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26092171
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25624791
112* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25244893
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24792167
114* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24727291
115GATA1_19941826_ChIP-Seq_K562_Human1.23765443
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23579704
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23529635
118VDR_22108803_ChIP-Seq_LS180_Human1.22668539
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.22488709
120MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22388547
121IGF1R_20145208_ChIP-Seq_DFB_Human1.20151512
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19932138
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.19915264
124IRF8_27001747_Chip-Seq_BMDM_Mouse1.18870634
125* NCOR1_26117541_ChIP-Seq_K562_Human1.18429153
126* BCL6_27268052_Chip-Seq_Bcells_Human1.18379549
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18239419
128* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17259513
129TP53_16413492_ChIP-PET_HCT116_Human1.16560875
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16158543
131POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15110052
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14990912
133P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14984338
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14023044
135IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13641891
136EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12788412
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12663406
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12006090
139RING1B_27294783_Chip-Seq_NPCs_Mouse1.11071266
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11013809
141GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10322564
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10023350
143RNF2_27304074_Chip-Seq_NSC_Mouse1.09926518
144STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09752003
145MYB_26560356_Chip-Seq_TH2_Human1.09520676
146* TP63_22573176_ChIP-Seq_HFKS_Human1.09176359
147PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07878839
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07724547
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07554366
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.07235663
151TCF4_23295773_ChIP-Seq_U87_Human1.07128849
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06624229
153TP53_22127205_ChIP-Seq_IMR90_Human1.06320574
154* RUNX2_22187159_ChIP-Seq_PCA_Human1.05908694
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05659694
156ER_23166858_ChIP-Seq_MCF-7_Human1.05637715
157NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04819482
158SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04774886
159AR_25329375_ChIP-Seq_VCAP_Human1.04558194
160NANOG_18555785_Chip-Seq_ESCs_Mouse1.02197851
161DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02162640
162* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00325185
163MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99430101
164CIITA_25753668_ChIP-Seq_RAJI_Human0.99325741
165UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98623967
166RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98223833
167TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98114882
168POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98114882
169WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97899914
170IRF8_21731497_ChIP-ChIP_J774_Mouse0.97483790
171AR_19668381_ChIP-Seq_PC3_Human0.97326815
172STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96513156
173CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95608261
174YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95310141
175SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95295782
176* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95181322
177FUS_26573619_Chip-Seq_HEK293_Human0.94777157
178STAT3_23295773_ChIP-Seq_U87_Human0.94475912
179EP300_21415370_ChIP-Seq_HL-1_Mouse0.93490733
180TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93252382
181AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93010436
182ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91371717
183KDM2B_26808549_Chip-Seq_REH_Human0.90563847
184CTCF_27219007_Chip-Seq_Bcells_Human0.90183785
185ARNT_22903824_ChIP-Seq_MCF-7_Human0.89687472
186SMAD3_21741376_ChIP-Seq_ESCs_Human0.88951864
187AHR_22903824_ChIP-Seq_MCF-7_Human0.85571759
188EGR1_19032775_ChIP-ChIP_M12_Human0.85356987
189OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83114748
190SMAD3_21741376_ChIP-Seq_HESCs_Human0.82855341
191LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82198745
192MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80992359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.37443556
2MP0004859_abnormal_synaptic_plasticity5.00826273
3MP0006276_abnormal_autonomic_nervous3.78215817
4MP0003635_abnormal_synaptic_transmissio3.59461907
5MP0004270_analgesia3.43314340
6MP0003172_abnormal_lysosome_physiology3.26586718
7MP0003436_decreased_susceptibility_to3.23115253
8MP0003763_abnormal_thymus_physiology3.02655856
9MP0002063_abnormal_learning/memory/cond2.99106818
10MP0003303_peritoneal_inflammation2.98736239
11MP0009745_abnormal_behavioral_response2.96830286
12MP0002064_seizures2.80640485
13MP0003705_abnormal_hypodermis_morpholog2.75698001
14MP0001486_abnormal_startle_reflex2.69678560
15MP0005058_abnormal_lysosome_morphology2.64308436
16MP0009046_muscle_twitch2.61029770
17MP0001968_abnormal_touch/_nociception2.53303705
18MP0009278_abnormal_bone_marrow2.53025575
19MP0002572_abnormal_emotion/affect_behav2.50058978
20MP0005076_abnormal_cell_differentiation2.38910860
21MP0004381_abnormal_hair_follicle2.37813266
22MP0002272_abnormal_nervous_system2.37702420
23MP0001835_abnormal_antigen_presentation2.30893683
24MP0005423_abnormal_somatic_nervous2.28918656
25MP0002734_abnormal_mechanical_nocicepti2.25471372
26MP0005451_abnormal_body_composition2.17472771
27MP0003300_gastrointestinal_ulcer2.16953021
28MP0001800_abnormal_humoral_immune2.14857920
29MP0002837_dystrophic_cardiac_calcinosis2.12260435
30MP0002184_abnormal_innervation2.12245615
31MP0000685_abnormal_immune_system2.12231689
32MP0004947_skin_inflammation2.11899261
33MP0004145_abnormal_muscle_electrophysio2.08999017
34MP0008260_abnormal_autophagy2.04613599
35MP0001502_abnormal_circadian_rhythm2.04609815
36MP0003137_abnormal_impulse_conducting2.03388263
37MP0001440_abnormal_grooming_behavior2.03078465
38MP0005409_darkened_coat_color1.91384944
39MP0002419_abnormal_innate_immunity1.90050248
40MP0005025_abnormal_response_to1.89878296
41MP0002396_abnormal_hematopoietic_system1.89762946
42MP0005387_immune_system_phenotype1.89091303
43MP0001790_abnormal_immune_system1.89091303
44MP0001529_abnormal_vocalization1.88258772
45MP0000778_abnormal_nervous_system1.85752309
46MP0001873_stomach_inflammation1.83825321
47MP0001501_abnormal_sleep_pattern1.82330763
48MP0003091_abnormal_cell_migration1.81973226
49MP0005000_abnormal_immune_tolerance1.81646430
50MP0002067_abnormal_sensory_capabilities1.79075916
51MP0000920_abnormal_myelination1.79035138
52MP0001905_abnormal_dopamine_level1.76095677
53MP0002420_abnormal_adaptive_immunity1.76093876
54MP0002735_abnormal_chemical_nociception1.75406864
55MP0001970_abnormal_pain_threshold1.75273707
56MP0002723_abnormal_immune_serum1.74599265
57MP0001819_abnormal_immune_cell1.74387005
58MP0002736_abnormal_nociception_after1.73008845
59MP0002733_abnormal_thermal_nociception1.70021959
60MP0002452_abnormal_antigen_presenting1.69588969
61MP0003191_abnormal_cellular_cholesterol1.67691931
62MP0003329_amyloid_beta_deposits1.65595759
63MP0005551_abnormal_eye_electrophysiolog1.61625013
64MP0001849_ear_inflammation1.61344148
65MP0004142_abnormal_muscle_tone1.58904502
66MP0002398_abnormal_bone_marrow1.58016103
67MP0001984_abnormal_olfaction1.55832028
68MP0005671_abnormal_response_to1.54465858
69MP0010155_abnormal_intestine_physiology1.53945559
70MP0003724_increased_susceptibility_to1.53855139
71MP0002557_abnormal_social/conspecific_i1.52537338
72MP0003453_abnormal_keratinocyte_physiol1.52197564
73MP0000751_myopathy1.51565458
74MP0002933_joint_inflammation1.50189167
75MP0005386_behavior/neurological_phenoty1.49783132
76MP0004924_abnormal_behavior1.49783132
77MP0002822_catalepsy1.49056472
78MP0002405_respiratory_system_inflammati1.48620791
79MP0000716_abnormal_immune_system1.46108158
80MP0002882_abnormal_neuron_morphology1.45803044
81MP0008569_lethality_at_weaning1.42915201
82MP0002066_abnormal_motor_capabilities/c1.41663286
83MP0000703_abnormal_thymus_morphology1.41583302
84MP0005379_endocrine/exocrine_gland_phen1.41323260
85MP0009840_abnormal_foam_cell1.40778001
86MP0004742_abnormal_vestibular_system1.40704642
87MP0001485_abnormal_pinna_reflex1.39501632
88MP0002998_abnormal_bone_remodeling1.39053953
89MP0001533_abnormal_skeleton_physiology1.38588702
90MP0004085_abnormal_heartbeat1.38263326
91MP0000955_abnormal_spinal_cord1.35886641
92MP0003866_abnormal_defecation1.35323649
93MP0001851_eye_inflammation1.30002218
94MP0003879_abnormal_hair_cell1.29809211
95MP0005464_abnormal_platelet_physiology1.29773518
96MP0004808_abnormal_hematopoietic_stem1.29185038
97MP0003690_abnormal_glial_cell1.29141507
98MP0009333_abnormal_splenocyte_physiolog1.28707573
99MP0005645_abnormal_hypothalamus_physiol1.27840388
100MP0004885_abnormal_endolymph1.25949600
101MP0001545_abnormal_hematopoietic_system1.25324165
102MP0005397_hematopoietic_system_phenotyp1.25324165
103MP0001188_hyperpigmentation1.24539075
104MP0001958_emphysema1.23352703
105MP0009780_abnormal_chondrocyte_physiolo1.22876554
106MP0003950_abnormal_plasma_membrane1.21992285
107MP0003183_abnormal_peptide_metabolism1.20723690
108MP0002722_abnormal_immune_system1.19948548
109MP0003634_abnormal_glial_cell1.19533170
110MP0002909_abnormal_adrenal_gland1.17833755
111MP0002429_abnormal_blood_cell1.17296380
112MP0002229_neurodegeneration1.16996845
113MP0002166_altered_tumor_susceptibility1.15134584
114MP0005666_abnormal_adipose_tissue1.13026671
115MP0000858_altered_metastatic_potential1.12793878
116MP0002009_preneoplasia1.11436618
117MP0004811_abnormal_neuron_physiology1.09953224
118MP0000015_abnormal_ear_pigmentation1.08854137
119MP0003279_aneurysm1.08260718
120MP0004185_abnormal_adipocyte_glucose1.06360731
121MP0000689_abnormal_spleen_morphology1.06243200
122MP0005310_abnormal_salivary_gland1.05735579
123MP0002152_abnormal_brain_morphology1.05247430
124MP0002752_abnormal_somatic_nervous1.04851636
125MP0001963_abnormal_hearing_physiology1.04593556
126MP0000566_synostosis1.03543624
127MP0000631_abnormal_neuroendocrine_gland0.99824910
128MP0002163_abnormal_gland_morphology0.99491636
129MP0005646_abnormal_pituitary_gland0.99025789
130MP0004036_abnormal_muscle_relaxation0.97079572
131MP0001845_abnormal_inflammatory_respons0.96723700
132MP0003828_pulmonary_edema0.96297662
133MP0003633_abnormal_nervous_system0.95610811
134MP0003566_abnormal_cell_adhesion0.95157194
135MP0009785_altered_susceptibility_to0.95077068
136MP0006082_CNS_inflammation0.94747552
137MP0009379_abnormal_foot_pigmentation0.93855984
138MP0004264_abnormal_extraembryonic_tissu0.93637050
139MP0006072_abnormal_retinal_apoptosis0.92420604
140MP0001986_abnormal_taste_sensitivity0.92284813
141MP0003631_nervous_system_phenotype0.91436747
142MP0005375_adipose_tissue_phenotype0.91223698
143MP0000465_gastrointestinal_hemorrhage0.89935652
144MP0002638_abnormal_pupillary_reflex0.88728009
145MP0005621_abnormal_cell_physiology0.86261323
146MP0004858_abnormal_nervous_system0.85167701
147MP0008961_abnormal_basal_metabolism0.84786655
148MP0002148_abnormal_hypersensitivity_rea0.82444221
149MP0005535_abnormal_body_temperature0.82200348
150MP0002069_abnormal_eating/drinking_beha0.81840268
151MP0003632_abnormal_nervous_system0.81316977
152MP0000733_abnormal_muscle_development0.80057346
153MP0000003_abnormal_adipose_tissue0.79988871
154MP0008874_decreased_physiological_sensi0.79508132
155MP0010386_abnormal_urinary_bladder0.77818458
156MP0001299_abnormal_eye_distance/0.77369991
157MP0004215_abnormal_myocardial_fiber0.76695298
158MP0005023_abnormal_wound_healing0.75901078
159MP0000749_muscle_degeneration0.75717364
160MP0000604_amyloidosis0.74618954
161MP0000747_muscle_weakness0.74214559
162MP0009931_abnormal_skin_appearance0.73965612
163MP0003122_maternal_imprinting0.73186985
164MP0005195_abnormal_posterior_eye0.72836776
165MP0000249_abnormal_blood_vessel0.72699494
166MP0000026_abnormal_inner_ear0.72611335
167MP0009115_abnormal_fat_cell0.72400216
168MP0002090_abnormal_vision0.71530378
169MP0001348_abnormal_lacrimal_gland0.70508360
170MP0003075_altered_response_to0.70212904
171MP0004130_abnormal_muscle_cell0.68588670
172MP0000767_abnormal_smooth_muscle0.68500053
173MP0005171_absent_coat_pigmentation0.67653116
174MP0008469_abnormal_protein_level0.66554647
175MP0003136_yellow_coat_color0.66438021
176MP0003656_abnormal_erythrocyte_physiolo0.66212354
177MP0002132_abnormal_respiratory_system0.65662865
178MP0005253_abnormal_eye_physiology0.65037308
179MP0004510_myositis0.64571881
180MP0004883_abnormal_blood_vessel0.64403598
181MP0003045_fibrosis0.57942209
182MP0001943_abnormal_respiration0.56774007
183MP0004484_altered_response_of0.56385859
184MP0005410_abnormal_fertilization0.56025154
185MP0003938_abnormal_ear_development0.52931793

Predicted human phenotypes

RankGene SetZ-score
1Overriding aorta (HP:0002623)5.87956111
2Insomnia (HP:0100785)5.77929384
3Elfin facies (HP:0004428)5.58785139
4Abnormality of the lower motor neuron (HP:0002366)5.51679080
5Hyperacusis (HP:0010780)5.50586301
6Myokymia (HP:0002411)5.12761125
7Renovascular hypertension (HP:0100817)4.81580155
8Flat cornea (HP:0007720)4.79623572
9Focal motor seizures (HP:0011153)4.50567795
10Focal seizures (HP:0007359)4.30091072
11Amyotrophic lateral sclerosis (HP:0007354)4.21367305
12Renal duplication (HP:0000075)4.04974334
13Abnormality of the diencephalon (HP:0010662)3.75646373
14Eczematoid dermatitis (HP:0000976)3.74405851
15Visual hallucinations (HP:0002367)3.66943185
16Neurofibrillary tangles (HP:0002185)3.63384831
17Obstructive sleep apnea (HP:0002870)3.58530417
18Atonic seizures (HP:0010819)3.47793406
19Sensory axonal neuropathy (HP:0003390)3.44607274
20Abnormality of the fingertips (HP:0001211)3.44544590
21Broad face (HP:0000283)3.38033360
22Absence seizures (HP:0002121)3.34842017
23Colitis (HP:0002583)3.33219070
24Epileptic encephalopathy (HP:0200134)3.29487106
25Megalocornea (HP:0000485)3.26004252
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.23850803
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.23850803
28Cerebral inclusion bodies (HP:0100314)3.19021977
29Supranuclear gaze palsy (HP:0000605)3.12884013
30Febrile seizures (HP:0002373)3.07518928
31Rimmed vacuoles (HP:0003805)3.02451481
32Dialeptic seizures (HP:0011146)2.97748172
33Cerebral aneurysm (HP:0004944)2.90077012
34Shoulder girdle muscle weakness (HP:0003547)2.90056231
35Spastic gait (HP:0002064)2.89815270
36Abnormality of the corticospinal tract (HP:0002492)2.89278269
37Thin bony cortex (HP:0002753)2.88340888
38Increased IgE level (HP:0003212)2.81971815
39Progressive cerebellar ataxia (HP:0002073)2.76084447
40Generalized tonic-clonic seizures (HP:0002069)2.75734143
41Bladder diverticulum (HP:0000015)2.71861881
42Urinary bladder sphincter dysfunction (HP:0002839)2.70264166
43Broad-based gait (HP:0002136)2.70044087
44Ankle clonus (HP:0011448)2.67011869
45Cellulitis (HP:0100658)2.65620633
46Gastrointestinal inflammation (HP:0004386)2.62566458
47Abnormality of the vocal cords (HP:0008777)2.58854046
48Papilledema (HP:0001085)2.54045942
49Patellar dislocation (HP:0002999)2.49771012
50Inflammation of the large intestine (HP:0002037)2.47837807
51Bowel diverticulosis (HP:0005222)2.47833613
52Humeroradial synostosis (HP:0003041)2.47602246
53Synostosis involving the elbow (HP:0003938)2.47602246
54Upper motor neuron abnormality (HP:0002127)2.43240649
55Hemorrhage of the eye (HP:0011885)2.39214516
56Hyperventilation (HP:0002883)2.38802156
57Muscle hypertrophy of the lower extremities (HP:0008968)2.38409985
58Recurrent fungal infections (HP:0002841)2.37813992
59Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.33948903
60Dysostosis multiplex (HP:0000943)2.33773360
61Gingivitis (HP:0000230)2.29743190
62Dysmetria (HP:0001310)2.29384540
63Action tremor (HP:0002345)2.28550354
64Parakeratosis (HP:0001036)2.26572502
65Abnormal eating behavior (HP:0100738)2.25857309
66Flat acetabular roof (HP:0003180)2.23814396
67Pustule (HP:0200039)2.23720211
68Thoracic kyphosis (HP:0002942)2.23653943
69Abnormality of the thoracic spine (HP:0100711)2.23387089
70Abnormality of the axillary hair (HP:0100134)2.22285939
71Abnormality of secondary sexual hair (HP:0009888)2.22285939
72Mucopolysacchariduria (HP:0008155)2.21560691
73Urinary glycosaminoglycan excretion (HP:0003541)2.21560691
74Recurrent bacterial skin infections (HP:0005406)2.21186161
75Interstitial pulmonary disease (HP:0006530)2.19189741
76Recurrent abscess formation (HP:0002722)2.19050624
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18534849
78Cervical subluxation (HP:0003308)2.18324375
79Arnold-Chiari malformation (HP:0002308)2.17931226
80Termporal pattern (HP:0011008)2.17842854
81Insidious onset (HP:0003587)2.17842854
82Impaired vibration sensation in the lower limbs (HP:0002166)2.17346090
83Hemiparesis (HP:0001269)2.17252874
84Annular pancreas (HP:0001734)2.15973441
85Agammaglobulinemia (HP:0004432)2.15726289
86Hypercalcemia (HP:0003072)2.15319026
87Periorbital edema (HP:0100539)2.14801266
88Abnormality of polysaccharide metabolism (HP:0011012)2.13648064
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13648064
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13648064
91Gastrointestinal infarctions (HP:0005244)2.13202007
92Progressive inability to walk (HP:0002505)2.12426388
93Mediastinal lymphadenopathy (HP:0100721)2.11342094
94Panhypogammaglobulinemia (HP:0003139)2.10043222
95Facial edema (HP:0000282)2.09674568
96Meningitis (HP:0001287)2.09508395
97Abnormality of macrophages (HP:0004311)2.09307703
98Slow saccadic eye movements (HP:0000514)2.09213069
99Scanning speech (HP:0002168)2.07389297
100Recurrent viral infections (HP:0004429)2.06752948
101Posterior embryotoxon (HP:0000627)2.06599174
102Dislocated radial head (HP:0003083)2.06041186
103Emphysema (HP:0002097)2.06009418
104Recurrent cutaneous fungal infections (HP:0011370)2.05970969
105Chronic mucocutaneous candidiasis (HP:0002728)2.05970969
106Calf muscle hypertrophy (HP:0008981)2.04531151
107Hypercalciuria (HP:0002150)2.03700857
108Abnormal delayed hypersensitivity skin test (HP:0002963)2.03306867
109Lower limb muscle weakness (HP:0007340)2.01993721
110Myositis (HP:0100614)2.01576618
111Anxiety (HP:0000739)2.00551901
112Epileptiform EEG discharges (HP:0011182)1.99718518
113Polyphagia (HP:0002591)1.97483975
114Spontaneous hematomas (HP:0007420)1.95360872
115Abnormality of the line of Schwalbe (HP:0008048)1.94669313
116Palpebral edema (HP:0100540)1.93088431
117Excessive salivation (HP:0003781)1.92700829
118Drooling (HP:0002307)1.92700829
119EEG with generalized epileptiform discharges (HP:0011198)1.92391000
120Abnormality of the radial head (HP:0003995)1.91959785
121Gaze-evoked nystagmus (HP:0000640)1.91616907
122Myotonia (HP:0002486)1.91160571
123Elevated erythrocyte sedimentation rate (HP:0003565)1.90910867
124Neuronal loss in central nervous system (HP:0002529)1.90676298
125Amblyopia (HP:0000646)1.89281467
126Abnormality of glycolipid metabolism (HP:0010969)1.88979197
127Abnormality of liposaccharide metabolism (HP:0010968)1.88979197
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.88979197
129Aneurysm (HP:0002617)1.88349764
130Chest pain (HP:0100749)1.88288034
131Prolonged bleeding time (HP:0003010)1.87167823
132Distal lower limb amyotrophy (HP:0008944)1.87123896
133Urinary urgency (HP:0000012)1.86886620
134Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86669684
135Recurrent gram-negative bacterial infections (HP:0005420)1.86467854
136Truncal ataxia (HP:0002078)1.84413324
137Increased cerebral lipofuscin (HP:0011813)1.83869150
138Obstructive lung disease (HP:0006536)1.83528829
139Chronic obstructive pulmonary disease (HP:0006510)1.83528829
140J-shaped sella turcica (HP:0002680)1.83222570
141Retinal dysplasia (HP:0007973)1.82935861
142Peripheral hypomyelination (HP:0007182)1.82685138
143Epistaxis (HP:0000421)1.82041445
144Ulnar bowing (HP:0003031)1.81371959
145Onion bulb formation (HP:0003383)1.80998225
146Polygenic inheritance (HP:0010982)1.80409862
147Abnormality of macular pigmentation (HP:0008002)1.79836052
148Abnormality of the columella (HP:0009929)1.79432439
149Viral hepatitis (HP:0006562)1.79192928
150Deformed sella turcica (HP:0002681)1.76737369
151Gastrointestinal stroma tumor (HP:0100723)1.76165519
152Supernumerary nipples (HP:0002558)1.75090629
153Bulbar palsy (HP:0001283)1.75078198
154Increased connective tissue (HP:0009025)1.73714883
155Recurrent skin infections (HP:0001581)1.73531447
156Hallux valgus (HP:0001822)1.72681575
157Gait imbalance (HP:0002141)1.72529644
158Joint stiffness (HP:0001387)1.71484022
159Restrictive lung disease (HP:0002091)1.71399675
160Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71064480
161Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70858509
162Pointed chin (HP:0000307)1.70571399
163Hypsarrhythmia (HP:0002521)1.70396046
164Hypoplasia of the iris (HP:0007676)1.70137521
165Centrally nucleated skeletal muscle fibers (HP:0003687)1.70055356
166Rapidly progressive (HP:0003678)1.69749142
167Increased circulating renin level (HP:0000848)1.68919275
168Spondylolisthesis (HP:0003302)1.68878979
169Poor eye contact (HP:0000817)1.68778169
170Vasculitis (HP:0002633)1.67853424
171Distal upper limb amyotrophy (HP:0007149)1.67696197
172Upper limb amyotrophy (HP:0009129)1.67696197
173Diplopia (HP:0000651)1.67687742
174Abnormality of binocular vision (HP:0011514)1.67687742
175Biconcave vertebral bodies (HP:0004586)1.67654586
176Dysmetric saccades (HP:0000641)1.67625574
177Obsessive-compulsive behavior (HP:0000722)1.67607250
178Absent speech (HP:0001344)1.67509092
179Clonus (HP:0002169)1.67263615
180Syringomyelia (HP:0003396)1.67087085
181Spinal cord lesions (HP:0100561)1.67087085
182Segmental peripheral demyelination/remyelination (HP:0003481)1.65370757
183Metaphyseal cupping (HP:0003021)1.63988033
184Germ cell neoplasia (HP:0100728)1.63702661
185Mitral regurgitation (HP:0001653)1.62876594
186Asymmetry of the thorax (HP:0001555)1.62707346
187Verrucae (HP:0200043)1.62100717
188Papilloma (HP:0012740)1.62100717
189Turricephaly (HP:0000262)1.61276528
190Vertebral arch anomaly (HP:0008438)1.61103104
191Protrusio acetabuli (HP:0003179)1.60468204
192Long eyelashes (HP:0000527)1.59876829
193Disproportionate tall stature (HP:0001519)1.58919427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK17.82825334
2TRIB34.21312149
3CDC42BPA3.55959230
4MARK13.25145761
5EPHA43.01702116
6NTRK22.98260351
7NTRK32.84367720
8ERN12.80667158
9CDK122.78690569
10MAP4K12.60542969
11CASK2.40587941
12PNCK2.17122928
13SIK12.15994321
14ROCK22.09962753
15SMG12.02991012
16TNIK2.00730550
17RIPK11.94674178
18FGFR41.88932247
19NTRK11.83891349
20MAP3K131.83666448
21EEF2K1.76228914
22MAP3K101.75443549
23MAP2K31.72176275
24PKN21.69853458
25STK391.66988806
26PAK61.64557513
27ZAP701.63768030
28RIPK41.63688659
29OXSR11.63179590
30FES1.61654602
31TYK21.61226645
32ARAF1.58991734
33MINK11.58982646
34MAP3K91.57181541
35CAMKK11.47151917
36BCR1.37972603
37MAP3K41.34319152
38MAP3K71.30969424
39CDK51.30196503
40UHMK11.28973952
41EPHB11.25474255
42PKN11.24327390
43ROCK11.23235174
44PHKG21.21856079
45PHKG11.21856079
46BTK1.20911210
47MAP3K141.19173912
48FGFR31.15638155
49GRK61.14562658
50TYRO31.14199454
51GRK51.13470406
52MAPK131.12717468
53CAMK2D1.12238402
54TBK11.12098822
55JAK11.11373313
56CDK191.10976686
57JAK31.09611913
58CSK1.03512120
59MTOR1.02377548
60PDGFRA1.01567636
61CAMK2B1.01078557
62CAMK2A0.99545161
63FGR0.98086169
64HIPK20.97657411
65IKBKE0.97526812
66IRAK40.96931230
67DAPK20.95622773
68TTN0.94704852
69MUSK0.94298299
70SIK20.93574496
71PLK20.92201065
72MAPK110.91031892
73MAP2K70.90358167
74MAP3K10.90118619
75SYK0.89138240
76HCK0.89056591
77PRKCE0.86162433
78BMPR20.84733182
79MAP3K60.83790602
80PAK30.82133523
81PTK60.81836222
82PDK10.81354573
83PRPF4B0.80509986
84MAP3K30.79374458
85SGK30.79301016
86PTK2B0.79029303
87PRKCG0.77998545
88ITK0.77663658
89MAPK70.77231286
90SIK30.75599723
91CSF1R0.75523245
92IRAK20.75261879
93MST1R0.74599102
94KSR10.73191429
95CAMK1D0.73102323
96IRAK30.73050275
97GRK70.71009964
98LCK0.70752403
99DMPK0.70481068
100NME10.70409894
101ADRBK20.70163837
102TNK20.70054818
103PRKD30.69641926
104STK380.68858220
105FGFR20.68408948
106MAP3K120.67710518
107KIT0.66926121
108RPS6KL10.66553493
109RPS6KC10.66553493
110JAK20.66076941
111CDK40.64704016
112PDGFRB0.64422178
113MAP3K110.63810369
114SGK10.63237605
115WNK40.62774108
116ICK0.62399400
117FER0.60514302
118KSR20.59655513
119BRD40.59113654
120TAOK10.58883965
121MAPKAPK50.58053751
122SGK2230.54221154
123SGK4940.54221154
124DYRK20.53420006
125WNK10.53375964
126MARK30.52334979
127PRKCQ0.52093226
128INSRR0.52019842
129CAMK2G0.51319075
130RPS6KA60.51272386
131DYRK1A0.49059036
132CAMK1G0.48460020
133CDK180.48367903
134SGK20.47989020
135LYN0.47815876
136CDK60.47765905
137CHUK0.47574183
138RET0.47569059
139CDK140.47552430
140LRRK20.47476999
141STK240.46631466
142PRKD20.46546100
143CAMK40.46189110
144MAP2K40.46028209
145CSNK1G20.46016796
146PRKACA0.45876929
147CAMK10.45870187
148NEK60.45472273
149MELK0.45098187
150CDK150.44866184
151MAP2K60.44702167
152DYRK1B0.44567434
153PAK10.44408885
154BLK0.43580168
155FYN0.43420235
156DDR20.42966653
157CSNK1G30.42207807
158MAPK150.42089753
159MAP2K20.40821506
160PDPK10.40677393
161MARK20.40417216
162PRKCH0.40249580
163PRKCB0.39536607
164CDK11A0.36958408
165MAPK120.35996928
166CSNK1A1L0.35497959
167RPS6KA20.35136019
168DAPK10.34630358
169RPS6KA30.34577995
170MAPKAPK20.34495556
171CAMKK20.33590867
172MAP3K20.33463707
173MAP2K10.32081756

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86642403
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89077357
3Glutamatergic synapse_Homo sapiens_hsa047242.73473488
4GABAergic synapse_Homo sapiens_hsa047272.69905459
5Synaptic vesicle cycle_Homo sapiens_hsa047212.56670005
6Circadian entrainment_Homo sapiens_hsa047132.50703525
7Morphine addiction_Homo sapiens_hsa050322.48135957
8Other glycan degradation_Homo sapiens_hsa005112.39501899
9Oxidative phosphorylation_Homo sapiens_hsa001902.21966015
10Serotonergic synapse_Homo sapiens_hsa047262.12427902
11Cardiac muscle contraction_Homo sapiens_hsa042602.08035344
12Long-term potentiation_Homo sapiens_hsa047202.06557650
13Axon guidance_Homo sapiens_hsa043602.01748735
14B cell receptor signaling pathway_Homo sapiens_hsa046622.01271772
15Taste transduction_Homo sapiens_hsa047421.98652666
16Olfactory transduction_Homo sapiens_hsa047401.97857254
17Acute myeloid leukemia_Homo sapiens_hsa052211.93683189
18Salivary secretion_Homo sapiens_hsa049701.92868158
19Amphetamine addiction_Homo sapiens_hsa050311.91892987
20Alzheimers disease_Homo sapiens_hsa050101.89229718
21Long-term depression_Homo sapiens_hsa047301.87261433
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85302527
23Cholinergic synapse_Homo sapiens_hsa047251.85086742
24Dopaminergic synapse_Homo sapiens_hsa047281.82153658
25Insulin secretion_Homo sapiens_hsa049111.81716194
26Renin secretion_Homo sapiens_hsa049241.78175856
27Parkinsons disease_Homo sapiens_hsa050121.75008076
28Osteoclast differentiation_Homo sapiens_hsa043801.74083954
29Non-small cell lung cancer_Homo sapiens_hsa052231.66258807
30Notch signaling pathway_Homo sapiens_hsa043301.66154755
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60196268
32Chronic myeloid leukemia_Homo sapiens_hsa052201.60061018
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58986235
34Gastric acid secretion_Homo sapiens_hsa049711.58963478
35Collecting duct acid secretion_Homo sapiens_hsa049661.57591058
36Cocaine addiction_Homo sapiens_hsa050301.55888224
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52809887
38Calcium signaling pathway_Homo sapiens_hsa040201.51790632
39Phototransduction_Homo sapiens_hsa047441.48599822
40Leishmaniasis_Homo sapiens_hsa051401.47490503
41T cell receptor signaling pathway_Homo sapiens_hsa046601.46657997
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.45464619
43Oxytocin signaling pathway_Homo sapiens_hsa049211.40013547
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37860347
45mTOR signaling pathway_Homo sapiens_hsa041501.33292288
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.31677084
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29689447
48Primary immunodeficiency_Homo sapiens_hsa053401.25683576
49Pancreatic cancer_Homo sapiens_hsa052121.24715733
50Endometrial cancer_Homo sapiens_hsa052131.24204307
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23774893
52Toxoplasmosis_Homo sapiens_hsa051451.20598499
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20216622
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.19528358
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17356054
56GnRH signaling pathway_Homo sapiens_hsa049121.17313381
57Inositol phosphate metabolism_Homo sapiens_hsa005621.15530443
58Huntingtons disease_Homo sapiens_hsa050161.14102072
59Staphylococcus aureus infection_Homo sapiens_hsa051501.13736145
60Gap junction_Homo sapiens_hsa045401.13003057
61Influenza A_Homo sapiens_hsa051641.11857342
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10742486
63cAMP signaling pathway_Homo sapiens_hsa040241.10527184
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09336201
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08505894
66Tuberculosis_Homo sapiens_hsa051521.08291835
67TNF signaling pathway_Homo sapiens_hsa046681.06890508
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06646100
69Prolactin signaling pathway_Homo sapiens_hsa049171.06219797
70Hepatitis B_Homo sapiens_hsa051611.05306229
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04290114
72Measles_Homo sapiens_hsa051621.03635578
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03516566
74Hepatitis C_Homo sapiens_hsa051601.03285039
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01986997
76Fatty acid elongation_Homo sapiens_hsa000621.00800469
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00790108
78Type II diabetes mellitus_Homo sapiens_hsa049301.00545446
79Vascular smooth muscle contraction_Homo sapiens_hsa042701.00508662
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99838344
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99797220
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.97258409
83Ether lipid metabolism_Homo sapiens_hsa005650.96729156
84Vibrio cholerae infection_Homo sapiens_hsa051100.96622160
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94588478
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.91793175
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89838680
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.89433080
89Insulin resistance_Homo sapiens_hsa049310.88263426
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88047694
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87716910
92Dilated cardiomyopathy_Homo sapiens_hsa054140.87510671
93Autoimmune thyroid disease_Homo sapiens_hsa053200.86747840
94Allograft rejection_Homo sapiens_hsa053300.86264158
95Melanogenesis_Homo sapiens_hsa049160.86182467
96Pancreatic secretion_Homo sapiens_hsa049720.86158207
97Estrogen signaling pathway_Homo sapiens_hsa049150.84618813
98Lysine degradation_Homo sapiens_hsa003100.84209901
99Colorectal cancer_Homo sapiens_hsa052100.84100152
100Circadian rhythm_Homo sapiens_hsa047100.83912768
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82940481
102Graft-versus-host disease_Homo sapiens_hsa053320.80550148
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.80421928
104Dorso-ventral axis formation_Homo sapiens_hsa043200.80303629
105Herpes simplex infection_Homo sapiens_hsa051680.80188825
106Apoptosis_Homo sapiens_hsa042100.79950307
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79812227
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79481278
109Insulin signaling pathway_Homo sapiens_hsa049100.79374578
110Endocytosis_Homo sapiens_hsa041440.78089626
111Choline metabolism in cancer_Homo sapiens_hsa052310.77965098
112Prostate cancer_Homo sapiens_hsa052150.77128626
113Prion diseases_Homo sapiens_hsa050200.76841659
114ErbB signaling pathway_Homo sapiens_hsa040120.76734665
115Hematopoietic cell lineage_Homo sapiens_hsa046400.76087397
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.73591603
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73121399
118FoxO signaling pathway_Homo sapiens_hsa040680.73061519
119Viral myocarditis_Homo sapiens_hsa054160.72806360
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72239405
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.71828455
122Lysosome_Homo sapiens_hsa041420.71289570
123Glioma_Homo sapiens_hsa052140.71055460
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70982695
125Amoebiasis_Homo sapiens_hsa051460.68943053
126Small cell lung cancer_Homo sapiens_hsa052220.68613375
127HTLV-I infection_Homo sapiens_hsa051660.68363091
128Bladder cancer_Homo sapiens_hsa052190.67825857
129Fructose and mannose metabolism_Homo sapiens_hsa000510.66729564
130Focal adhesion_Homo sapiens_hsa045100.66287689
131HIF-1 signaling pathway_Homo sapiens_hsa040660.65952708
132Thyroid cancer_Homo sapiens_hsa052160.62334006
133Viral carcinogenesis_Homo sapiens_hsa052030.61979752
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61945176
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61411866
136Ras signaling pathway_Homo sapiens_hsa040140.61315133
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60197078
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60068670
139Pertussis_Homo sapiens_hsa051330.59971741
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59636017
141African trypanosomiasis_Homo sapiens_hsa051430.58153852
142MAPK signaling pathway_Homo sapiens_hsa040100.57239391
143Proteoglycans in cancer_Homo sapiens_hsa052050.56110902
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54033143
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53462449
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.53120399
147Renal cell carcinoma_Homo sapiens_hsa052110.52031260
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50942105
149Thyroid hormone synthesis_Homo sapiens_hsa049180.50355222
150SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45386001
151Steroid biosynthesis_Homo sapiens_hsa001000.45328211
152Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43095188
153Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42589972
154VEGF signaling pathway_Homo sapiens_hsa043700.42405089
155Butanoate metabolism_Homo sapiens_hsa006500.38214702
156Rheumatoid arthritis_Homo sapiens_hsa053230.38033859
157Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37013432
158Rap1 signaling pathway_Homo sapiens_hsa040150.31443464
159Sphingolipid metabolism_Homo sapiens_hsa006000.30329656
160Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26791384
161Ovarian steroidogenesis_Homo sapiens_hsa049130.26451172
162Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26323840
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.25186211
164Glucagon signaling pathway_Homo sapiens_hsa049220.24092489
165Alcoholism_Homo sapiens_hsa050340.23800178
166Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22609172
167Chemokine signaling pathway_Homo sapiens_hsa040620.22461269
168Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21817992
169Platelet activation_Homo sapiens_hsa046110.20463499
170Phagosome_Homo sapiens_hsa041450.20217198

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