CUBN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.27782027
2urate metabolic process (GO:0046415)9.16129577
3drug transport (GO:0015893)8.04449089
4lysine metabolic process (GO:0006553)7.81112861
5lysine catabolic process (GO:0006554)7.81112861
6drug catabolic process (GO:0042737)7.20602988
7regulation of guanylate cyclase activity (GO:0031282)7.00366827
8epoxygenase P450 pathway (GO:0019373)6.93980003
9organic cation transport (GO:0015695)6.85826509
10aminoglycoside antibiotic metabolic process (GO:0030647)6.80013544
11phosphate ion transport (GO:0006817)6.65650923
12modified amino acid transport (GO:0072337)6.35788590
13* lipoprotein transport (GO:0042953)6.06242894
14fat-soluble vitamin biosynthetic process (GO:0042362)6.01247950
15phosphate ion transmembrane transport (GO:0035435)5.91520698
16renal absorption (GO:0070293)5.87349082
17regulation of triglyceride catabolic process (GO:0010896)5.80858897
18excretion (GO:0007588)5.79990435
19quaternary ammonium group transport (GO:0015697)5.70557326
20positive regulation of guanylate cyclase activity (GO:0031284)5.63582985
21angiotensin maturation (GO:0002003)5.38489506
22cysteine metabolic process (GO:0006534)5.37953428
23regulation of systemic arterial blood pressure by hormone (GO:0001990)5.35657959
24regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.35657959
25endocrine process (GO:0050886)5.35657959
26* vitamin D metabolic process (GO:0042359)5.30530808
27aspartate family amino acid catabolic process (GO:0009068)5.30412739
28very-low-density lipoprotein particle assembly (GO:0034379)5.30297168
29phospholipid efflux (GO:0033700)5.15379201
30exogenous drug catabolic process (GO:0042738)5.10843600
31intestinal absorption (GO:0050892)5.08862364
32cellular glucuronidation (GO:0052695)5.02346735
33uronic acid metabolic process (GO:0006063)4.96613540
34glucuronate metabolic process (GO:0019585)4.96613540
35peptide catabolic process (GO:0043171)4.90052141
36flavonoid metabolic process (GO:0009812)4.86220056
37phosphate ion homeostasis (GO:0055062)4.85798919
38trivalent inorganic anion homeostasis (GO:0072506)4.85798919
39glyoxylate metabolic process (GO:0046487)4.84256139
40regulation of cholesterol esterification (GO:0010872)4.81689993
41nonribosomal peptide biosynthetic process (GO:0019184)4.75879333
42sulfur compound transport (GO:0072348)4.66924085
43regulation of systemic arterial blood pressure (GO:0003073)4.64572694
44homocysteine metabolic process (GO:0050667)4.63153951
45high-density lipoprotein particle remodeling (GO:0034375)4.62585096
46tricarboxylic acid metabolic process (GO:0072350)4.62086367
47response to mercury ion (GO:0046689)4.58978132
48carnitine transport (GO:0015879)4.55928629
49amino-acid betaine transport (GO:0015838)4.55928629
50peptide hormone processing (GO:0016486)4.42134100
51toxin transport (GO:1901998)4.41496185
52glutathione biosynthetic process (GO:0006750)4.41228642
53* vitamin transport (GO:0051180)4.40129269
54intestinal cholesterol absorption (GO:0030299)4.37665272
55serine family amino acid metabolic process (GO:0009069)4.37380304
56digestion (GO:0007586)4.37247206
57diacylglycerol metabolic process (GO:0046339)4.33857577
58virion attachment to host cell (GO:0019062)4.33362008
59adhesion of symbiont to host cell (GO:0044650)4.33362008
60regulation of cGMP biosynthetic process (GO:0030826)4.32789738
61short-chain fatty acid metabolic process (GO:0046459)4.31930056
62regulation of bile acid biosynthetic process (GO:0070857)4.27197914
63bile acid and bile salt transport (GO:0015721)4.19018167
64serine family amino acid catabolic process (GO:0009071)4.17032721
65cellular response to nitric oxide (GO:0071732)4.13720087
66oligosaccharide catabolic process (GO:0009313)4.12337598
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.10917607
68serine family amino acid biosynthetic process (GO:0009070)4.00153344
69renal system process involved in regulation of blood volume (GO:0001977)3.99442021
70reverse cholesterol transport (GO:0043691)3.98875897
71receptor guanylyl cyclase signaling pathway (GO:0007168)3.98820069
72amino-acid betaine metabolic process (GO:0006577)3.97968643
73regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.97504236
74response to phenylpropanoid (GO:0080184)3.94308120
75polyol transport (GO:0015791)3.93501788
76alkaloid metabolic process (GO:0009820)3.91489500
77drinking behavior (GO:0042756)3.91302104
78actin filament depolymerization (GO:0030042)3.86861495
79metanephric nephron tubule development (GO:0072234)3.86713961
80metanephric tubule development (GO:0072170)3.86713961
812-oxoglutarate metabolic process (GO:0006103)3.86529751
82cellular modified amino acid catabolic process (GO:0042219)3.81925742
83vitamin transmembrane transport (GO:0035461)3.78687874
84fructose metabolic process (GO:0006000)3.77244636
85cGMP biosynthetic process (GO:0006182)3.66170688
86bile acid metabolic process (GO:0008206)3.63587534
87peptide biosynthetic process (GO:0043043)3.63401460
88regulation of cholesterol homeostasis (GO:2000188)3.61686054
89regulation of cGMP metabolic process (GO:0030823)3.60751823
90cellular response to reactive nitrogen species (GO:1902170)3.57416249
91cholesterol efflux (GO:0033344)3.56535950
92adhesion of symbiont to host (GO:0044406)3.56290616
93vitamin A metabolic process (GO:0006776)3.52846918
94metanephric nephron epithelium development (GO:0072243)3.52158764
95glutamate metabolic process (GO:0006536)3.51642401
96carnitine metabolic process (GO:0009437)3.51352196
97proline metabolic process (GO:0006560)3.51293551
98fatty acid beta-oxidation (GO:0006635)3.50757428
99triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.47348497
100glomerulus development (GO:0032835)3.42049047
101acetyl-CoA metabolic process (GO:0006084)3.41967108
102glucose 6-phosphate metabolic process (GO:0051156)3.40106826
103* lipoprotein metabolic process (GO:0042157)3.39394879
104regulation of cellular extravasation (GO:0002691)3.38401810
105indole-containing compound catabolic process (GO:0042436)3.36281952
106indolalkylamine catabolic process (GO:0046218)3.36281952
107tryptophan catabolic process (GO:0006569)3.36281952
108valine metabolic process (GO:0006573)3.35166786
109transepithelial transport (GO:0070633)3.34767299
110plasma lipoprotein particle remodeling (GO:0034369)3.34350168
111protein-lipid complex remodeling (GO:0034368)3.34350168
112macromolecular complex remodeling (GO:0034367)3.34350168
113positive regulation of cGMP biosynthetic process (GO:0030828)3.34334218
114tryptophan metabolic process (GO:0006568)3.33865363
115glycolipid catabolic process (GO:0019377)3.30662181
116aromatic amino acid family catabolic process (GO:0009074)3.30637572
117alditol metabolic process (GO:0019400)3.29304131
118positive regulation of lipid catabolic process (GO:0050996)3.29011884
119branched-chain amino acid metabolic process (GO:0009081)3.28096149
120vitamin biosynthetic process (GO:0009110)3.27613984
121plasma lipoprotein particle organization (GO:0071827)3.26114395
122glycosylceramide metabolic process (GO:0006677)3.25866509
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.25783023
124L-phenylalanine metabolic process (GO:0006558)3.25783023
125sodium-independent organic anion transport (GO:0043252)3.25475409
126response to nitric oxide (GO:0071731)3.25322380
127heme transport (GO:0015886)3.25292180
128sulfate transmembrane transport (GO:1902358)3.24128665
129mRNA modification (GO:0016556)3.23518326
130positive regulation of glycoprotein biosynthetic process (GO:0010560)3.23144822
131glycosphingolipid catabolic process (GO:0046479)3.22939638
132amino acid transmembrane transport (GO:0003333)3.22625543
133fatty acid oxidation (GO:0019395)3.22435625
134NADH metabolic process (GO:0006734)3.21036163
135sodium ion transport (GO:0006814)3.20778422
136sodium ion homeostasis (GO:0055078)3.20188951
137hormone catabolic process (GO:0042447)3.19046516
138drug metabolic process (GO:0017144)3.18214052
139metanephric epithelium development (GO:0072207)3.17027408
140lipid oxidation (GO:0034440)3.16133719
141sterol homeostasis (GO:0055092)3.15962474
142regulation of protein glycosylation (GO:0060049)3.15915357
143sulfate transport (GO:0008272)3.09332397
144L-ascorbic acid metabolic process (GO:0019852)3.09197777
145erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08708711
146L-phenylalanine catabolic process (GO:0006559)3.08708711
147glycoside metabolic process (GO:0016137)3.08268121
148protein-lipid complex assembly (GO:0065005)3.08202222
149glutamine family amino acid biosynthetic process (GO:0009084)3.07762662
150omega-hydroxylase P450 pathway (GO:0097267)3.07317106
151positive regulation of lipoprotein lipase activity (GO:0051006)3.07146059
152positive regulation of triglyceride lipase activity (GO:0061365)3.07146059
153negative regulation of sterol transport (GO:0032372)3.07018413
154negative regulation of cholesterol transport (GO:0032375)3.07018413
155protein-lipid complex subunit organization (GO:0071825)3.06811006
156cholesterol homeostasis (GO:0042632)3.06796795
157urea cycle (GO:0000050)3.06082154
158cellular response to vitamin D (GO:0071305)3.05507972
159nephron tubule development (GO:0072080)3.04727459
160glutathione derivative biosynthetic process (GO:1901687)3.04389472
161glutathione derivative metabolic process (GO:1901685)3.04389472
162cellular carbohydrate catabolic process (GO:0044275)3.03989214
163plasma lipoprotein particle assembly (GO:0034377)3.03215048
164response to growth hormone (GO:0060416)3.02817207
165calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.01812046
166digestive system process (GO:0022600)2.99775971
167glycerol metabolic process (GO:0006071)2.97341137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.09871382
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.88691172
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.93265924
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.82672809
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.76726789
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.57863097
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.44879240
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.42842122
9AR_21909140_ChIP-Seq_LNCAP_Human3.22058014
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.06845084
11CLOCK_20551151_ChIP-Seq_293T_Human2.89920873
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68052306
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.52979883
14GATA4_25053715_ChIP-Seq_YYC3_Human2.48988317
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.45088393
16GATA6_25053715_ChIP-Seq_YYC3_Human2.39907962
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39099187
18SALL4_18804426_ChIP-ChIP_XEN_Mouse2.30368898
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.29921886
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.24463411
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.23815340
22GATA1_22025678_ChIP-Seq_K562_Human2.23551780
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.15157545
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10373906
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.00504797
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.97536461
27NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.91362292
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.87706093
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86396929
30HNF4A_19822575_ChIP-Seq_HepG2_Human1.80535176
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.78863625
32SOX2_20726797_ChIP-Seq_SW620_Human1.75327069
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73969698
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72396642
35VDR_22108803_ChIP-Seq_LS180_Human1.71128124
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.69231335
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67219571
38RACK7_27058665_Chip-Seq_MCF-7_Human1.66741915
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66223306
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66082765
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57303573
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55686994
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51082394
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50448560
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47903443
46BCAT_22108803_ChIP-Seq_LS180_Human1.47395736
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46444471
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45001147
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43556150
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42590315
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40737031
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39531677
53TCF4_22108803_ChIP-Seq_LS180_Human1.34582366
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33814948
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33507540
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33345592
57EGR1_19032775_ChIP-ChIP_M12_Human1.31249962
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30958835
59VDR_24787735_ChIP-Seq_THP-1_Human1.27806893
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26583758
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25537946
62* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25437429
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23462506
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23401326
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22097780
66ATF3_27146783_Chip-Seq_COLON_Human1.21707206
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19287282
68P300_19829295_ChIP-Seq_ESCs_Human1.18733934
69* SMAD3_21741376_ChIP-Seq_HESCs_Human1.18478149
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18260130
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18209947
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.17942738
73FOXA1_25552417_ChIP-Seq_VCAP_Human1.14073984
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12371068
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11317104
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09635530
77CBP_20019798_ChIP-Seq_JUKART_Human1.07685058
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07685058
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07526395
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07089796
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06724179
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06378141
83* PRDM14_20953172_ChIP-Seq_ESCs_Human1.06350694
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06178850
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04484636
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04122608
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04117414
88* GATA2_19941826_ChIP-Seq_K562_Human1.03551625
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03354456
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02882948
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02714485
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02601072
93* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02577959
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02505367
95* SMAD3_21741376_ChIP-Seq_EPCs_Human1.01559163
96LXR_22292898_ChIP-Seq_THP-1_Human1.01547340
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01378167
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99249127
99ER_23166858_ChIP-Seq_MCF-7_Human0.99211698
100* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98936663
101PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98315560
102GATA1_19941826_ChIP-Seq_K562_Human0.98155139
103* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97965171
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97273252
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97211814
106CJUN_26792858_Chip-Seq_BT549_Human0.97177326
107DROSHA_22980978_ChIP-Seq_HELA_Human0.97064880
108* STAT3_23295773_ChIP-Seq_U87_Human0.96439432
109TCF4_18268006_ChIP-ChIP_LS174T_Human0.95430916
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94974425
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.94925876
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94839030
113AHR_22903824_ChIP-Seq_MCF-7_Human0.94106777
114CEBPB_22108803_ChIP-Seq_LS180_Human0.92842422
115CREB1_26743006_Chip-Seq_LNCaP_Human0.92239885
116NANOG_20526341_ChIP-Seq_ESCs_Human0.92205881
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92205528
118GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92095235
119ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91832294
120* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91351748
121* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91044449
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.90885909
123CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90830933
124* SMAD4_21799915_ChIP-Seq_A2780_Human0.90541010
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90225134
126TP53_18474530_ChIP-ChIP_U2OS_Human0.89219290
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.88261524
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.88261524
129TCF4_23295773_ChIP-Seq_U87_Human0.88227843
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88202163
131STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87936909
132SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87918197
133CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87901121
134TP53_16413492_ChIP-PET_HCT116_Human0.87854976
135ETV1_20927104_ChIP-Seq_GIST48_Human0.87753648
136NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87727595
137SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87584570
138SOX2_19829295_ChIP-Seq_ESCs_Human0.87489938
139NANOG_19829295_ChIP-Seq_ESCs_Human0.87489938
140IRF8_21731497_ChIP-ChIP_J774_Mouse0.87363342
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87164226
142* CBP_21632823_ChIP-Seq_H3396_Human0.87146567
143RXR_22108803_ChIP-Seq_LS180_Human0.86506868
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86428540
145NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85718610
146AR_25329375_ChIP-Seq_VCAP_Human0.85682473
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85600257
148TP63_23658742_ChIP-Seq_EP156T_Human0.85529571
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.85276730
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85276730
151* CDX2_22108803_ChIP-Seq_LS180_Human0.84999500
152KLF5_25053715_ChIP-Seq_YYC3_Human0.83185714
153TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82972209
154ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81804081
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79773094
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78670274
157SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78306384
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.78114328
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.77606343
160SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76387807
161SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76387807
162FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75955242
163TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.74383285
164Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73936601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.61270817
2MP0004043_abnormal_pH_regulation4.64937549
3MP0003878_abnormal_ear_physiology4.27463674
4MP0005377_hearing/vestibular/ear_phenot4.27463674
5* MP0004019_abnormal_vitamin_homeostasis4.11519502
6MP0002139_abnormal_hepatobiliary_system3.96577054
7MP0005332_abnormal_amino_acid3.82078959
8* MP0009643_abnormal_urine_homeostasis3.23114732
9MP0002138_abnormal_hepatobiliary_system2.98397770
10MP0001765_abnormal_ion_homeostasis2.97966479
11MP0001666_abnormal_nutrient_absorption2.90372678
12MP0005365_abnormal_bile_salt2.75514726
13MP0003252_abnormal_bile_duct2.70563878
14MP0005085_abnormal_gallbladder_physiolo2.69383890
15MP0003195_calcinosis2.50916878
16MP0001958_emphysema2.47502347
17MP0008875_abnormal_xenobiotic_pharmacok2.44663861
18MP0010234_abnormal_vibrissa_follicle2.39745513
19MP0005636_abnormal_mineral_homeostasis2.38415322
20MP0001756_abnormal_urination2.37758569
21* MP0002136_abnormal_kidney_physiology2.33776418
22MP0009379_abnormal_foot_pigmentation2.19774686
23MP0005084_abnormal_gallbladder_morpholo2.15799386
24* MP0004264_abnormal_extraembryonic_tissu1.93176646
25MP0010155_abnormal_intestine_physiology1.83600038
26MP0000538_abnormal_urinary_bladder1.82430636
27MP0005409_darkened_coat_color1.74931807
28MP0003868_abnormal_feces_composition1.73005449
29MP0010329_abnormal_lipoprotein_level1.72587565
30MP0004147_increased_porphyrin_level1.67335763
31MP0005058_abnormal_lysosome_morphology1.62419785
32MP0003300_gastrointestinal_ulcer1.53995742
33MP0004272_abnormal_basement_membrane1.51297255
34MP0003718_maternal_effect1.50510259
35MP0009840_abnormal_foam_cell1.45649302
36MP0003191_abnormal_cellular_cholesterol1.42110288
37MP0003879_abnormal_hair_cell1.36783522
38MP0001501_abnormal_sleep_pattern1.30214939
39MP0003283_abnormal_digestive_organ1.23794824
40MP0008961_abnormal_basal_metabolism1.22359552
41MP0005451_abnormal_body_composition1.16472767
42MP0002876_abnormal_thyroid_physiology1.16426569
43MP0003705_abnormal_hypodermis_morpholog1.16339296
44MP0005584_abnormal_enzyme/coenzyme_acti1.14705772
45MP0004885_abnormal_endolymph1.12641418
46MP0002796_impaired_skin_barrier1.10380186
47MP0002089_abnormal_postnatal_growth/wei1.08595738
48MP0006054_spinal_hemorrhage1.08393836
49MP0005448_abnormal_energy_balance1.05036384
50MP0001188_hyperpigmentation1.03367700
51MP0003941_abnormal_skin_development1.03056893
52MP0000537_abnormal_urethra_morphology1.00971519
53MP0003806_abnormal_nucleotide_metabolis0.97215966
54MP0000678_abnormal_parathyroid_gland0.96250950
55MP0005319_abnormal_enzyme/_coenzyme0.93743176
56MP0002896_abnormal_bone_mineralization0.93194378
57MP0009115_abnormal_fat_cell0.89526692
58MP0008872_abnormal_physiological_respon0.88176037
59MP0000490_abnormal_crypts_of0.87936489
60MP0002118_abnormal_lipid_homeostasis0.87278263
61MP0005174_abnormal_tail_pigmentation0.86626193
62* MP0002135_abnormal_kidney_morphology0.86216341
63MP0003638_abnormal_response/metabolism_0.86120807
64MP0002098_abnormal_vibrissa_morphology0.86039619
65MP0001764_abnormal_homeostasis0.83568803
66MP0003183_abnormal_peptide_metabolism0.82256816
67MP0002971_abnormal_brown_adipose0.82057610
68MP0005501_abnormal_skin_physiology0.81647556
69MP0005410_abnormal_fertilization0.81571762
70MP0005666_abnormal_adipose_tissue0.80948423
71MP0001986_abnormal_taste_sensitivity0.80931558
72MP0004270_analgesia0.77319813
73MP0005166_decreased_susceptibility_to0.76287530
74MP0002928_abnormal_bile_duct0.75656767
75MP0002396_abnormal_hematopoietic_system0.75382003
76MP0000609_abnormal_liver_physiology0.74809840
77MP0000230_abnormal_systemic_arterial0.74640306
78MP0002822_catalepsy0.74416195
79MP0002168_other_aberrant_phenotype0.74318424
80MP0005167_abnormal_blood-brain_barrier0.72235986
81MP0003123_paternal_imprinting0.67272575
82MP0003186_abnormal_redox_activity0.66371608
83MP0001873_stomach_inflammation0.65339982
84MP0000015_abnormal_ear_pigmentation0.64836109
85MP0000462_abnormal_digestive_system0.64513836
86MP0009642_abnormal_blood_homeostasis0.62696136
87MP0001293_anophthalmia0.61954186
88MP0008469_abnormal_protein_level0.61446654
89MP0005408_hypopigmentation0.61395544
90MP0003953_abnormal_hormone_level0.60330378
91MP0000249_abnormal_blood_vessel0.60255805
92MP0000477_abnormal_intestine_morphology0.59741684
93MP0009384_cardiac_valve_regurgitation0.59070057
94MP0010678_abnormal_skin_adnexa0.58749344
95MP0002638_abnormal_pupillary_reflex0.57010956
96MP0001845_abnormal_inflammatory_respons0.56486185
97MP0009053_abnormal_anal_canal0.56061741
98MP0000516_abnormal_urinary_system0.55386893
99MP0005367_renal/urinary_system_phenotyp0.55386893
100MP0000371_diluted_coat_color0.55303619
101MP0004858_abnormal_nervous_system0.54304171
102MP0004484_altered_response_of0.53974075
103MP0002069_abnormal_eating/drinking_beha0.53913341
104MP0005395_other_phenotype0.53516183
105MP0006036_abnormal_mitochondrial_physio0.50373620
106MP0006138_congestive_heart_failure0.50120753
107MP0003866_abnormal_defecation0.49881546
108MP0003566_abnormal_cell_adhesion0.49530990
109MP0005535_abnormal_body_temperature0.49141183
110MP0000427_abnormal_hair_cycle0.48220764
111MP0003045_fibrosis0.48126753
112MP0000598_abnormal_liver_morphology0.47783814
113MP0009672_abnormal_birth_weight0.47598808
114MP0000604_amyloidosis0.47437382
115MP0003315_abnormal_perineum_morphology0.45717082
116MP0005334_abnormal_fat_pad0.44581432
117MP0001485_abnormal_pinna_reflex0.44113930
118MP0001177_atelectasis0.43294619
119MP0001849_ear_inflammation0.42652409
120MP0003329_amyloid_beta_deposits0.42065524
121MP0001664_abnormal_digestion0.41417508
122MP0010352_gastrointestinal_tract_polyps0.41352404
123MP0001663_abnormal_digestive_system0.39911687
124MP0000465_gastrointestinal_hemorrhage0.39467208
125MP0005381_digestive/alimentary_phenotyp0.38633000
126MP0008004_abnormal_stomach_pH0.38597859
127MP0002078_abnormal_glucose_homeostasis0.37901461
128MP0003724_increased_susceptibility_to0.37453121
129* MP0002086_abnormal_extraembryonic_tissu0.37393371
130MP0005670_abnormal_white_adipose0.36863995
131MP0009764_decreased_sensitivity_to0.36588652
132MP0001661_extended_life_span0.36307568
133MP0003172_abnormal_lysosome_physiology0.35935939
134MP0002697_abnormal_eye_size0.35847827
135MP0000534_abnormal_ureter_morphology0.35795390
136MP0000377_abnormal_hair_follicle0.35551319
137MP0005220_abnormal_exocrine_pancreas0.35209648
138MP0005376_homeostasis/metabolism_phenot0.34616056
139MP0002998_abnormal_bone_remodeling0.33717832
140MP0001730_embryonic_growth_arrest0.33127200
141MP0003795_abnormal_bone_structure0.32488131

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.11900245
2Metabolic alkalosis (HP:0200114)6.40359577
3Hypokalemic alkalosis (HP:0001949)6.33165614
4Hyperactive renin-angiotensin system (HP:0000841)6.24502180
5Abnormality of glutamine family amino acid metabolism (HP:0010902)6.18246029
6Hypomagnesemia (HP:0002917)6.16326143
7Proximal tubulopathy (HP:0000114)5.88147471
8Gout (HP:0001997)5.82875271
9Abnormal urine output (HP:0012590)5.61708062
10Polyuria (HP:0000103)5.58815575
11Abnormality of chloride homeostasis (HP:0011422)5.53680915
12Abnormality of magnesium homeostasis (HP:0004921)5.37776474
13Abnormality of renal excretion (HP:0011036)5.30045646
14Hyperglycinuria (HP:0003108)5.08977689
15Chronic diarrhea (HP:0002028)4.55759642
16Polydipsia (HP:0001959)4.46861578
17Abnormal drinking behavior (HP:0030082)4.46861578
18Tetany (HP:0001281)4.45708249
19Pigmentary retinal degeneration (HP:0001146)4.32419103
20Increased purine levels (HP:0004368)4.31741491
21Hyperuricemia (HP:0002149)4.31741491
22Abnormality of purine metabolism (HP:0004352)4.20245994
23Abnormality of renin-angiotensin system (HP:0000847)4.16547015
24Abnormality of serine family amino acid metabolism (HP:0010894)4.15717782
25Abnormality of glycine metabolism (HP:0010895)4.15717782
26Hypercalciuria (HP:0002150)4.02935632
27Alkalosis (HP:0001948)4.02414498
28Hyperaldosteronism (HP:0000859)3.99930735
29Renal salt wasting (HP:0000127)3.99737236
30Abnormality of proline metabolism (HP:0010907)3.98384738
31Hydroxyprolinuria (HP:0003080)3.98384738
32Abnormality of urine glucose concentration (HP:0011016)3.66477132
33Glycosuria (HP:0003076)3.66477132
34Hyperphosphaturia (HP:0003109)3.49168443
35Malnutrition (HP:0004395)3.45112520
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.40247954
37Delayed epiphyseal ossification (HP:0002663)3.35492899
38Hypokalemia (HP:0002900)3.33759756
39Generalized aminoaciduria (HP:0002909)3.33370766
40Abnormal urine phosphate concentration (HP:0012599)3.27565061
41Hypolipoproteinemia (HP:0010981)3.22085541
42Nephrolithiasis (HP:0000787)3.21283049
43Decreased circulating renin level (HP:0003351)3.21274054
44Widely patent fontanelles and sutures (HP:0004492)3.19699437
45Abnormality of nucleobase metabolism (HP:0010932)3.17281261
46* Confusion (HP:0001289)3.01535180
47Facial shape deformation (HP:0011334)2.99397239
48Potter facies (HP:0002009)2.99397239
49Nausea (HP:0002018)2.99380484
50Renal tubular acidosis (HP:0001947)2.99161620
51Steatorrhea (HP:0002570)2.91483710
52Ketoacidosis (HP:0001993)2.90863552
53Thin bony cortex (HP:0002753)2.89504405
54Congenital sensorineural hearing impairment (HP:0008527)2.79269959
55Focal segmental glomerulosclerosis (HP:0000097)2.77265605
56Hypoglycemic coma (HP:0001325)2.74881710
57Hypophosphatemia (HP:0002148)2.74716307
58Hyperglycinemia (HP:0002154)2.73460824
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.69742751
60Abnormality of potassium homeostasis (HP:0011042)2.69553456
61Dehydration (HP:0001944)2.68557881
62Nephrocalcinosis (HP:0000121)2.61405863
63Metaphyseal cupping (HP:0003021)2.53157003
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.48711190
65Ileus (HP:0002595)2.48259356
66Rickets (HP:0002748)2.44628043
67Bicornuate uterus (HP:0000813)2.41681693
68Abnormality of fatty-acid metabolism (HP:0004359)2.40399261
69Ketosis (HP:0001946)2.39031348
70Hypophosphatemic rickets (HP:0004912)2.38716168
71Vascular calcification (HP:0004934)2.37895851
72* Abnormality of vitamin metabolism (HP:0100508)2.36458446
73Posterior subcapsular cataract (HP:0007787)2.36182595
74Enlarged kidneys (HP:0000105)2.31816522
75Hyperammonemia (HP:0001987)2.23316527
76Xanthomatosis (HP:0000991)2.22709577
77Adrenal overactivity (HP:0002717)2.18584764
78Abdominal distention (HP:0003270)2.17510812
79High anterior hairline (HP:0009890)2.17320312
80Chorioretinal atrophy (HP:0000533)2.15966426
81Hypoglycemic seizures (HP:0002173)2.14322036
82Cardiovascular calcification (HP:0011915)2.14086707
83Symptomatic seizures (HP:0011145)2.13691227
84Vacuolated lymphocytes (HP:0001922)2.12492968
85* Abnormality of the vitamin B12 metabolism (HP:0004341)2.12443048
86Tubulointerstitial fibrosis (HP:0005576)2.11685380
87Hypobetalipoproteinemia (HP:0003563)2.11428154
88Epidermoid cyst (HP:0200040)2.09563099
89Abnormal glucose tolerance (HP:0001952)2.05841737
90Abnormality of sodium homeostasis (HP:0010931)2.04911468
91Wide cranial sutures (HP:0010537)2.03926267
92Hyponatremia (HP:0002902)2.03590657
93Pancreatic islet-cell hyperplasia (HP:0004510)2.01943131
94Subcapsular cataract (HP:0000523)2.01168814
95Bilateral sensorineural hearing impairment (HP:0008619)2.00711335
96Chondrocalcinosis (HP:0000934)2.00662713
97Abnormality of the costochondral junction (HP:0000919)2.00037021
98Tubular atrophy (HP:0000092)1.99966805
99Delayed CNS myelination (HP:0002188)1.99606379
100* Abnormality of vitamin B metabolism (HP:0004340)1.99465626
101Partial agenesis of the corpus callosum (HP:0001338)1.98133021
102Glomerulosclerosis (HP:0000096)1.94812076
103Metabolic acidosis (HP:0001942)1.94348582
104Abnormal enzyme/coenzyme activity (HP:0012379)1.93882684
105Hypotension (HP:0002615)1.92509661
106Poikilocytosis (HP:0004447)1.91476697
107Intrahepatic cholestasis (HP:0001406)1.91021699
108Fat malabsorption (HP:0002630)1.90937229
109Hypoplasia of the iris (HP:0007676)1.90013428
110Abnormal albumin level (HP:0012116)1.89685608
111Hypoalbuminemia (HP:0003073)1.89685608
112Acanthocytosis (HP:0001927)1.89289645
113Abnormality of alkaline phosphatase activity (HP:0004379)1.88941859
114Abnormal tarsal ossification (HP:0008369)1.87462345
115Enlarged epiphyses (HP:0010580)1.86274689
116Abnormality of Sharpey fibers (HP:0100685)1.85694580
117Renal tubular dysfunction (HP:0000124)1.84659632
118Dicarboxylic aciduria (HP:0003215)1.84597291
119Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84597291
120Osteomalacia (HP:0002749)1.80535563
121Exercise-induced muscle cramps (HP:0003710)1.79770961
122Hyperinsulinemic hypoglycemia (HP:0000825)1.75987011
123Vomiting (HP:0002013)1.75161459
124Hypothermia (HP:0002045)1.71892747
125White forelock (HP:0002211)1.70429349
126Abnormality of monocarboxylic acid metabolism (HP:0010996)1.68751387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.07615392
2WNK37.04062101
3OXSR16.26611060
4MST44.26110057
5STK393.44610369
6SCYL22.68987001
7STK38L2.43672415
8MST1R2.26669327
9FRK2.19453548
10NEK12.17718991
11GRK62.16792373
12STK101.86611172
13TNIK1.73004539
14LRRK21.69988768
15PIK3CG1.57518413
16PDK31.46904447
17PDK41.46904447
18NLK1.41051699
19BCKDK1.40760665
20PTK61.37913083
21MET1.37700882
22EPHA21.35167467
23WNK11.34493133
24RIPK11.32527160
25EPHA41.30412876
26MAP3K21.29755540
27LATS11.18135960
28SGK4941.17591612
29SGK2231.17591612
30PTK21.15072955
31MAP3K31.10926002
32PRKCI1.08568157
33PDK21.07325209
34CASK1.07292548
35STK381.07272962
36LMTK21.05269403
37TYK21.03635014
38MAP3K101.02307422
39PAK40.99435050
40TESK20.97571153
41NME10.95594281
42EPHA30.94809010
43GRK10.92666715
44MAP3K80.90933786
45FER0.90060094
46FGFR40.83331368
47PRKG20.82151238
48TEC0.80580170
49TAOK30.79600451
50FGFR30.79361819
51TXK0.79197540
52EPHB10.78766789
53SGK30.78126936
54AKT30.78067093
55PAK30.77138100
56MAP4K10.76002017
57EPHB20.75999405
58AKT20.73552419
59TTK0.70953355
60MAP3K120.70341488
61ADRBK20.66396036
62GSK3A0.63837108
63NUAK10.63155768
64MAP3K70.62273814
65PIK3CA0.61543900
66MAP2K20.60543893
67BMPR1B0.58205251
68PRKAA10.57036104
69DAPK20.56423432
70PINK10.55944298
71NEK60.55636724
72MAP2K60.54135841
73SGK20.53944344
74PDPK10.53029783
75MAPK110.52581224
76BTK0.52443870
77PIM10.50218534
78PRKAA20.50194479
79SGK10.48851163
80IRAK10.48181775
81ERN10.47283717
82PDGFRA0.46676976
83MYLK0.46446722
84TRIB30.46185404
85PKN20.40892062
86STK30.40858313
87BMX0.40742994
88DDR20.40161310
89JAK10.39872937
90CAMKK20.39715074
91CDK190.38948797
92INSRR0.36996561
93KIT0.36608267
94MAP3K10.35505324
95TLK10.34886959
96KSR20.34344081
97PDK10.34144890
98TIE10.33948550
99STK110.33911177
100CSK0.33442504
101ERBB20.32118827
102ITK0.31245823
103KSR10.31082849
104ROCK10.30549011
105MUSK0.30223484
106FGFR20.30197628
107PRKCE0.30125436
108DYRK1B0.29000636
109PRKACA0.28581723
110RET0.27824828
111MAP4K20.27340886
112TGFBR20.27204797
113MAPK70.26249892
114YES10.24995085
115IGF1R0.24838909
116SYK0.24640380
117PDGFRB0.24631676
118LCK0.24414485
119FYN0.23589372
120CSNK1A10.23572779
121MAP3K110.22808439
122MELK0.22640762
123MAP2K10.21934680
124MTOR0.21865850
125FGFR10.19639956
126CDK120.19257060
127ZAK0.19094364
128ERBB40.18783663
129INSR0.18599742
130PRKCD0.18375697
131SRC0.16436603
132MATK0.15696939
133NTRK10.15438022
134PRKCA0.14758879
135TGFBR10.14040614
136PRKACG0.12460983
137ROCK20.12429522
138PRKCQ0.12345299
139ACVR1B0.08832521
140PRKCZ0.08409836
141TAOK10.07988160
142LATS20.06205500
143AURKB0.06036929
144NEK20.05834011
145ABL20.05284250
146PTK2B0.04472270

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.46205136
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.31312866
3* Vitamin digestion and absorption_Homo sapiens_hsa049773.06835198
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83371298
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78109128
6Butanoate metabolism_Homo sapiens_hsa006502.70643689
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.64996646
8Renin-angiotensin system_Homo sapiens_hsa046142.57722440
9Mineral absorption_Homo sapiens_hsa049782.48568414
10Fat digestion and absorption_Homo sapiens_hsa049752.38785522
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32843317
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29875978
13Bile secretion_Homo sapiens_hsa049762.25008819
14Linoleic acid metabolism_Homo sapiens_hsa005912.19459647
15Propanoate metabolism_Homo sapiens_hsa006402.15729772
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15265226
17Tryptophan metabolism_Homo sapiens_hsa003802.14458868
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14263402
19Protein digestion and absorption_Homo sapiens_hsa049742.11647402
20Fatty acid degradation_Homo sapiens_hsa000712.06913313
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03580481
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01709108
23Pyruvate metabolism_Homo sapiens_hsa006201.96622950
24Peroxisome_Homo sapiens_hsa041461.83883157
25Nitrogen metabolism_Homo sapiens_hsa009101.81027526
26Sulfur metabolism_Homo sapiens_hsa009201.76158633
27beta-Alanine metabolism_Homo sapiens_hsa004101.67855941
28Carbon metabolism_Homo sapiens_hsa012001.63097058
29Starch and sucrose metabolism_Homo sapiens_hsa005001.62902681
30Arginine and proline metabolism_Homo sapiens_hsa003301.59457663
31Collecting duct acid secretion_Homo sapiens_hsa049661.54984773
32Glutathione metabolism_Homo sapiens_hsa004801.54439519
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.53889395
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.53143022
35Histidine metabolism_Homo sapiens_hsa003401.52654693
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51120799
37Arginine biosynthesis_Homo sapiens_hsa002201.49411808
38Lysine degradation_Homo sapiens_hsa003101.44810125
39PPAR signaling pathway_Homo sapiens_hsa033201.41277756
40Fructose and mannose metabolism_Homo sapiens_hsa000511.38477894
41Galactose metabolism_Homo sapiens_hsa000521.37723157
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34761387
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31095149
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30794933
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.26446943
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24300682
47Fatty acid metabolism_Homo sapiens_hsa012121.23599009
48Glycerolipid metabolism_Homo sapiens_hsa005611.21313113
49Ether lipid metabolism_Homo sapiens_hsa005651.17164298
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13177932
51Other glycan degradation_Homo sapiens_hsa005111.12361977
52Biosynthesis of amino acids_Homo sapiens_hsa012301.10665281
53Folate biosynthesis_Homo sapiens_hsa007901.02292882
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99186523
55Selenocompound metabolism_Homo sapiens_hsa004500.95418178
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92261350
57Thyroid hormone synthesis_Homo sapiens_hsa049180.89497814
58Systemic lupus erythematosus_Homo sapiens_hsa053220.87756575
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85462649
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76316784
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.70718819
62Sphingolipid metabolism_Homo sapiens_hsa006000.57051024
63ABC transporters_Homo sapiens_hsa020100.56672503
64Phenylalanine metabolism_Homo sapiens_hsa003600.56555991
65Pentose phosphate pathway_Homo sapiens_hsa000300.56153373
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.53752822
67Tight junction_Homo sapiens_hsa045300.53687817
68Fatty acid biosynthesis_Homo sapiens_hsa000610.51897499
69Lysosome_Homo sapiens_hsa041420.50003700
70Steroid biosynthesis_Homo sapiens_hsa001000.48326977
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.46840219
72Caffeine metabolism_Homo sapiens_hsa002320.46728018
73Pancreatic secretion_Homo sapiens_hsa049720.46628703
74Gastric acid secretion_Homo sapiens_hsa049710.45354068
75Metabolic pathways_Homo sapiens_hsa011000.40455543
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40401574
77Renin secretion_Homo sapiens_hsa049240.40384771
78Asthma_Homo sapiens_hsa053100.38589739
79Fatty acid elongation_Homo sapiens_hsa000620.37443047
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.35810647
81Vibrio cholerae infection_Homo sapiens_hsa051100.34571152
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.33965237
83Allograft rejection_Homo sapiens_hsa053300.33278675
84Autoimmune thyroid disease_Homo sapiens_hsa053200.32484347
85Graft-versus-host disease_Homo sapiens_hsa053320.31805343
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.30187904
87Cocaine addiction_Homo sapiens_hsa050300.30107971
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28792464
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28480765
90Alcoholism_Homo sapiens_hsa050340.26298693
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.25680135
92Glucagon signaling pathway_Homo sapiens_hsa049220.24437451
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.23921817
94Insulin resistance_Homo sapiens_hsa049310.23214750
95Retinol metabolism_Homo sapiens_hsa008300.22315736
96Serotonergic synapse_Homo sapiens_hsa047260.22007948
97Bladder cancer_Homo sapiens_hsa052190.21893622
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.21183477
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20583854
100Inositol phosphate metabolism_Homo sapiens_hsa005620.19607430
101ECM-receptor interaction_Homo sapiens_hsa045120.18805594
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16929170
103Chemical carcinogenesis_Homo sapiens_hsa052040.16779490
104Arachidonic acid metabolism_Homo sapiens_hsa005900.15618278
105Choline metabolism in cancer_Homo sapiens_hsa052310.15381487
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13640012
107Hippo signaling pathway_Homo sapiens_hsa043900.11003448
108Type I diabetes mellitus_Homo sapiens_hsa049400.09949003
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09451553
110Insulin secretion_Homo sapiens_hsa049110.09366291
111Adherens junction_Homo sapiens_hsa045200.08950611
112One carbon pool by folate_Homo sapiens_hsa006700.08763100
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.08413989
114Hedgehog signaling pathway_Homo sapiens_hsa043400.08238256
115Ovarian steroidogenesis_Homo sapiens_hsa049130.07995851
116Amphetamine addiction_Homo sapiens_hsa050310.07555877
117African trypanosomiasis_Homo sapiens_hsa051430.07049003
118Small cell lung cancer_Homo sapiens_hsa052220.06331041
119Tyrosine metabolism_Homo sapiens_hsa003500.05923840
120Dorso-ventral axis formation_Homo sapiens_hsa043200.05610397
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.05501661
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.04196899
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.02758278
124Hepatitis C_Homo sapiens_hsa051600.02256444
125Hematopoietic cell lineage_Homo sapiens_hsa046400.01940519
126Staphylococcus aureus infection_Homo sapiens_hsa051500.01561898
127Synaptic vesicle cycle_Homo sapiens_hsa047210.00925272

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