CTXN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.30826771
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.23802971
3locomotory exploration behavior (GO:0035641)5.78495009
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.77858775
5synaptic vesicle exocytosis (GO:0016079)5.71556043
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.57712147
7glutamate secretion (GO:0014047)5.46029420
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.44261628
9vocalization behavior (GO:0071625)5.38215425
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.28328586
11regulation of glutamate receptor signaling pathway (GO:1900449)5.25270827
12protein localization to synapse (GO:0035418)4.99374397
13regulation of synapse structural plasticity (GO:0051823)4.98575609
14regulation of synaptic vesicle exocytosis (GO:2000300)4.96356291
15regulation of neuronal synaptic plasticity (GO:0048168)4.92951141
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.83021417
17exploration behavior (GO:0035640)4.68073754
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.59129493
19layer formation in cerebral cortex (GO:0021819)4.52186594
20regulation of synaptic vesicle transport (GO:1902803)4.49032310
21dendritic spine morphogenesis (GO:0060997)4.44998084
22neuron cell-cell adhesion (GO:0007158)4.39579079
23neurotransmitter secretion (GO:0007269)4.24103005
24synaptic transmission, glutamatergic (GO:0035249)4.14020534
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13750693
26neuronal action potential propagation (GO:0019227)4.07668166
27cerebellar granule cell differentiation (GO:0021707)4.04619949
28neurotransmitter-gated ion channel clustering (GO:0072578)4.03590107
29positive regulation of synapse maturation (GO:0090129)4.02461855
30glutamate receptor signaling pathway (GO:0007215)3.99974470
31regulation of dendritic spine morphogenesis (GO:0061001)3.98092803
32regulation of excitatory postsynaptic membrane potential (GO:0060079)3.94613725
33neuron recognition (GO:0008038)3.94358789
34regulation of synaptic plasticity (GO:0048167)3.92999954
35long-term memory (GO:0007616)3.92801608
36positive regulation of membrane potential (GO:0045838)3.86467892
37axonal fasciculation (GO:0007413)3.85099770
38neuron-neuron synaptic transmission (GO:0007270)3.85044698
39axon ensheathment in central nervous system (GO:0032291)3.80503741
40central nervous system myelination (GO:0022010)3.80503741
41regulation of postsynaptic membrane potential (GO:0060078)3.72292596
42G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.70434428
43auditory behavior (GO:0031223)3.70314034
44positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.65396268
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64786507
46long-term synaptic potentiation (GO:0060291)3.60729359
47positive regulation of neurotransmitter secretion (GO:0001956)3.59049166
48behavioral fear response (GO:0001662)3.56081620
49behavioral defense response (GO:0002209)3.56081620
50establishment of mitochondrion localization (GO:0051654)3.55710749
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.55190390
52regulation of voltage-gated calcium channel activity (GO:1901385)3.51791957
53axonemal dynein complex assembly (GO:0070286)3.50603398
54neuromuscular process controlling balance (GO:0050885)3.49787393
55activation of protein kinase A activity (GO:0034199)3.47639634
56synaptic vesicle endocytosis (GO:0048488)3.47181052
57dendritic spine organization (GO:0097061)3.46645686
58proline transport (GO:0015824)3.44076701
59response to auditory stimulus (GO:0010996)3.41644020
60cell migration in hindbrain (GO:0021535)3.41029799
61positive regulation of neurotransmitter transport (GO:0051590)3.40787082
62regulation of neurotransmitter secretion (GO:0046928)3.40001118
63regulation of dendritic spine development (GO:0060998)3.34315991
64positive regulation of dendritic spine development (GO:0060999)3.33976701
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.32940147
66dendrite morphogenesis (GO:0048813)3.31241805
67regulation of vesicle fusion (GO:0031338)3.30710199
68mitochondrion transport along microtubule (GO:0047497)3.30341445
69establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.30341445
70fear response (GO:0042596)3.29238664
71prepulse inhibition (GO:0060134)3.29047945
72postsynaptic membrane organization (GO:0001941)3.27854440
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27561073
74neurotransmitter transport (GO:0006836)3.26919276
75transmission of nerve impulse (GO:0019226)3.26148104
76negative regulation of microtubule polymerization (GO:0031115)3.25815488
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.24429448
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.21489531
79learning (GO:0007612)3.17433445
80dopamine receptor signaling pathway (GO:0007212)3.16103643
81regulation of female receptivity (GO:0045924)3.15398279
82cellular potassium ion homeostasis (GO:0030007)3.15263994
83neuronal ion channel clustering (GO:0045161)3.14139046
84regulation of neurotransmitter transport (GO:0051588)3.14123955
85adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.13038305
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12192878
87potassium ion homeostasis (GO:0055075)3.12117638
88positive regulation of synaptic transmission (GO:0050806)3.12007348
89innervation (GO:0060384)3.11797217
90regulation of neurotransmitter levels (GO:0001505)3.11379341
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10535862
92cell communication by electrical coupling (GO:0010644)3.09931401
93gamma-aminobutyric acid transport (GO:0015812)3.09145801
94regulation of glutamate secretion (GO:0014048)3.08812989
95pyrimidine nucleobase catabolic process (GO:0006208)3.08607576
96membrane depolarization (GO:0051899)3.08202509
97regulation of synaptic transmission (GO:0050804)3.06514838
98cerebellar Purkinje cell differentiation (GO:0021702)3.05283937
99central nervous system projection neuron axonogenesis (GO:0021952)3.05126427
100negative regulation of dendrite development (GO:2000171)3.03921945
101L-amino acid import (GO:0043092)3.01841527
102regulation of synapse maturation (GO:0090128)3.01153021
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99534561
104membrane hyperpolarization (GO:0060081)2.96919014
105social behavior (GO:0035176)2.92441742
106intraspecies interaction between organisms (GO:0051703)2.92441742
107neuromuscular process (GO:0050905)2.90680229
108cerebellar Purkinje cell layer development (GO:0021680)2.90099652
109chemosensory behavior (GO:0007635)2.89796010
110vesicle transport along microtubule (GO:0047496)2.88848541
111sodium ion export (GO:0071436)2.88054590
112synaptic transmission (GO:0007268)2.87321147
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87118152
114amino acid import (GO:0043090)2.86118525
115negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85721988
116presynaptic membrane organization (GO:0097090)2.85284432
117positive regulation of dendrite development (GO:1900006)2.82441296
118left/right pattern formation (GO:0060972)2.78940846
119neuromuscular synaptic transmission (GO:0007274)2.78169212
120negative regulation of dendrite morphogenesis (GO:0050774)2.78156626
121regulation of ARF protein signal transduction (GO:0032012)2.76540690
122response to parathyroid hormone (GO:0071107)2.76473537
123mating behavior (GO:0007617)2.74703381
124cell differentiation in hindbrain (GO:0021533)2.74509698
125behavioral response to cocaine (GO:0048148)2.73506688
126positive regulation of synapse assembly (GO:0051965)2.72613001
127axon extension (GO:0048675)2.70453388
128cell-cell junction maintenance (GO:0045217)2.70388323
129regulation of dendrite morphogenesis (GO:0048814)2.67079982
130presynaptic membrane assembly (GO:0097105)2.66469112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.88914595
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.46534985
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.32012786
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.31907087
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14410986
6RARB_27405468_Chip-Seq_BRAIN_Mouse3.12421159
7GBX2_23144817_ChIP-Seq_PC3_Human3.07661852
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.98643520
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.98643520
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.97261389
11REST_21632747_ChIP-Seq_MESCs_Mouse2.88009656
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.83382075
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77957837
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70512392
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66515893
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.66499479
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63158980
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.59158197
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57239137
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.53851059
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50587524
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.48678354
23DROSHA_22980978_ChIP-Seq_HELA_Human2.46869192
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.44499094
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.43832651
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.42250199
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29398466
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24403859
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21039712
30LXR_22292898_ChIP-Seq_THP-1_Human2.01523988
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.84497642
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80171277
33AR_21572438_ChIP-Seq_LNCaP_Human1.69370067
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59798995
35* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59479467
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.58692194
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55499828
38P68_20966046_ChIP-Seq_HELA_Human1.53825570
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50306782
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50189503
41SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46028987
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45371469
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45160133
44SMC4_20622854_ChIP-Seq_HELA_Human1.44464443
45* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43376084
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.40947453
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40684432
48* RING1B_27294783_Chip-Seq_NPCs_Mouse1.38559719
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36802507
50* TET1_21451524_ChIP-Seq_MESCs_Mouse1.36527788
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35956936
52ZNF274_21170338_ChIP-Seq_K562_Hela1.35259394
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32273582
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.31618323
55* CREB1_26743006_Chip-Seq_LNCaP_Human1.30289467
56SMAD4_21799915_ChIP-Seq_A2780_Human1.30002429
57KDM2B_26808549_Chip-Seq_K562_Human1.28724810
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27253485
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26722472
60* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25201717
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24385291
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21701019
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20884798
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19622082
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19507735
66KDM2B_26808549_Chip-Seq_DND41_Human1.19302699
67MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19146742
68TAF15_26573619_Chip-Seq_HEK293_Human1.17430161
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.16185526
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15544017
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14900065
72AR_19668381_ChIP-Seq_PC3_Human1.14696044
73RNF2_27304074_Chip-Seq_NSC_Mouse1.13432355
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.12072867
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.11954624
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11808170
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11503621
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.11303344
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11179444
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11084265
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11083055
82OCT4_19829295_ChIP-Seq_ESCs_Human1.10544352
83P300_19829295_ChIP-Seq_ESCs_Human1.09932863
84RACK7_27058665_Chip-Seq_MCF-7_Human1.09683573
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.09637871
86IGF1R_20145208_ChIP-Seq_DFB_Human1.06327101
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.06314965
88AR_25329375_ChIP-Seq_VCAP_Human1.04445474
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01956580
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01869028
91* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01717355
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01598429
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00253807
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00244937
95SOX3_22085726_ChIP-Seq_NPCs_Mouse0.99547324
96* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99067458
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.98818153
98* CTCF_27219007_Chip-Seq_Bcells_Human0.97926037
99* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97364764
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96700221
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95108190
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94664184
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94503155
104SA1_27219007_Chip-Seq_Bcells_Human0.94001769
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.92325098
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91799992
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.91135847
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90974919
109STAT3_23295773_ChIP-Seq_U87_Human0.90558751
110STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89105426
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89029646
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88782856
113CTCF_20526341_ChIP-Seq_ESCs_Human0.88663100
114MYC_27129775_Chip-Seq_CORNEA_Mouse0.87744671
115KLF4_19829295_ChIP-Seq_ESCs_Human0.87411169
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87236152
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87120794
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.86831099
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.86002224
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85691923
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85235303
122* TP53_23651856_ChIP-Seq_MEFs_Mouse0.85042042
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.84403212
124* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84311201
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83910405
126TRIM28_21343339_ChIP-Seq_HEK293_Human0.83469899
127AHR_22903824_ChIP-Seq_MCF-7_Human0.83445241
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82885198
129CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82843754
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82609540
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82426175
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82426175
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82064541
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82007935
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81948527
136TP53_22127205_ChIP-Seq_IMR90_Human0.81828888
137POU5F1_16518401_ChIP-PET_MESCs_Mouse0.80347562
138JUN_21703547_ChIP-Seq_K562_Human0.80231387
139RUNX2_22187159_ChIP-Seq_PCA_Human0.78637136
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.77426401
141GATA1_26923725_Chip-Seq_HPCs_Mouse0.77171974
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76924198
143TCF4_23295773_ChIP-Seq_U87_Human0.76434440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.23942259
2MP0003880_abnormal_central_pattern4.76009216
3MP0003635_abnormal_synaptic_transmissio4.28808046
4MP0004270_analgesia3.79290138
5MP0002063_abnormal_learning/memory/cond3.60985100
6MP0002822_catalepsy3.42871315
7MP0009745_abnormal_behavioral_response3.36938999
8MP0002064_seizures3.02832325
9MP0002572_abnormal_emotion/affect_behav2.84927315
10MP0001968_abnormal_touch/_nociception2.82500329
11MP0005423_abnormal_somatic_nervous2.72578457
12MP0001486_abnormal_startle_reflex2.51891554
13MP0009046_muscle_twitch2.42716167
14MP0002734_abnormal_mechanical_nocicepti2.40908379
15MP0002272_abnormal_nervous_system2.34029321
16MP0000778_abnormal_nervous_system2.19118549
17MP0001440_abnormal_grooming_behavior2.15911746
18MP0002736_abnormal_nociception_after2.11423052
19MP0002735_abnormal_chemical_nociception2.04495821
20MP0001501_abnormal_sleep_pattern1.99554284
21MP0002733_abnormal_thermal_nociception1.99321967
22MP0004811_abnormal_neuron_physiology1.98635978
23MP0009379_abnormal_foot_pigmentation1.96616149
24MP0001970_abnormal_pain_threshold1.89970775
25MP0004858_abnormal_nervous_system1.88282837
26MP0002557_abnormal_social/conspecific_i1.88058281
27MP0002184_abnormal_innervation1.87142977
28MP0003122_maternal_imprinting1.87006898
29MP0009780_abnormal_chondrocyte_physiolo1.83054537
30MP0001984_abnormal_olfaction1.81975153
31MP0001529_abnormal_vocalization1.78711132
32MP0006276_abnormal_autonomic_nervous1.78379278
33MP0005646_abnormal_pituitary_gland1.69409970
34MP0003329_amyloid_beta_deposits1.68942369
35MP0004924_abnormal_behavior1.68939527
36MP0005386_behavior/neurological_phenoty1.68939527
37MP0002067_abnormal_sensory_capabilities1.68082363
38MP0002909_abnormal_adrenal_gland1.66999837
39MP0008569_lethality_at_weaning1.65541424
40MP0000566_synostosis1.62907624
41MP0000955_abnormal_spinal_cord1.59467097
42MP0003879_abnormal_hair_cell1.54268571
43MP0002249_abnormal_larynx_morphology1.53964608
44MP0002882_abnormal_neuron_morphology1.48242013
45MP0001346_abnormal_lacrimal_gland1.45179329
46MP0002066_abnormal_motor_capabilities/c1.36768328
47MP0001905_abnormal_dopamine_level1.36469362
48MP0004885_abnormal_endolymph1.36252476
49MP0003787_abnormal_imprinting1.36141934
50MP0005645_abnormal_hypothalamus_physiol1.36062353
51MP0002152_abnormal_brain_morphology1.26440391
52MP0001502_abnormal_circadian_rhythm1.24125149
53MP0010030_abnormal_orbit_morphology1.18062369
54MP0004133_heterotaxia1.14997613
55MP0003633_abnormal_nervous_system1.13397515
56MP0008961_abnormal_basal_metabolism1.10604487
57MP0001348_abnormal_lacrimal_gland1.10163143
58MP0003938_abnormal_ear_development1.05561848
59MP0000569_abnormal_digit_pigmentation1.03838491
60MP0005499_abnormal_olfactory_system1.01456776
61MP0005394_taste/olfaction_phenotype1.01456776
62MP0003942_abnormal_urinary_system1.00376928
63MP0002069_abnormal_eating/drinking_beha0.99750940
64MP0003631_nervous_system_phenotype0.97652569
65MP0000026_abnormal_inner_ear0.97226771
66MP0003075_altered_response_to0.96721271
67MP0003283_abnormal_digestive_organ0.94481768
68MP0000049_abnormal_middle_ear0.94074851
69MP0000751_myopathy0.93546786
70MP0008872_abnormal_physiological_respon0.92153104
71MP0000631_abnormal_neuroendocrine_gland0.90787903
72MP0004142_abnormal_muscle_tone0.90593676
73MP0008789_abnormal_olfactory_epithelium0.87711069
74MP0002089_abnormal_postnatal_growth/wei0.86800870
75MP0010386_abnormal_urinary_bladder0.85997848
76MP0008874_decreased_physiological_sensi0.85069231
77MP0000579_abnormal_nail_morphology0.84555917
78MP0003861_abnormal_nervous_system0.83924063
79MP0001188_hyperpigmentation0.82550567
80MP0001177_atelectasis0.81047571
81MP0004085_abnormal_heartbeat0.79208841
82MP0005623_abnormal_meninges_morphology0.79006011
83MP0002752_abnormal_somatic_nervous0.77873632
84MP0003121_genomic_imprinting0.75923699
85MP0006292_abnormal_olfactory_placode0.75379606
86MP0002653_abnormal_ependyma_morphology0.75302995
87MP0003634_abnormal_glial_cell0.74316587
88MP0000920_abnormal_myelination0.73779531
89MP0002234_abnormal_pharynx_morphology0.73672555
90MP0001963_abnormal_hearing_physiology0.72472110
91MP0004742_abnormal_vestibular_system0.72374963
92MP0002638_abnormal_pupillary_reflex0.70402204
93MP0005535_abnormal_body_temperature0.70378170
94MP0004233_abnormal_muscle_weight0.70011557
95MP0003878_abnormal_ear_physiology0.69091942
96MP0005377_hearing/vestibular/ear_phenot0.69091942
97MP0000678_abnormal_parathyroid_gland0.68314978
98MP0002229_neurodegeneration0.68252328
99MP0001299_abnormal_eye_distance/0.67501652
100MP0005187_abnormal_penis_morphology0.66396894
101MP0002081_perinatal_lethality0.66349541
102MP0002116_abnormal_craniofacial_bone0.65760645
103MP0000013_abnormal_adipose_tissue0.65116874
104MP0010234_abnormal_vibrissa_follicle0.64921432
105MP0005167_abnormal_blood-brain_barrier0.64547947
106MP0003137_abnormal_impulse_conducting0.63486382
107MP0003123_paternal_imprinting0.63023111
108MP0000534_abnormal_ureter_morphology0.62521909
109MP0001664_abnormal_digestion0.61716483
110MP0003632_abnormal_nervous_system0.61432101
111MP0003119_abnormal_digestive_system0.61384519
112MP0000604_amyloidosis0.61297414
113MP0001293_anophthalmia0.61109587
114MP0004130_abnormal_muscle_cell0.60175514
115MP0001485_abnormal_pinna_reflex0.59424770
116MP0009053_abnormal_anal_canal0.59227076
117MP0002751_abnormal_autonomic_nervous0.59064185
118MP0004145_abnormal_muscle_electrophysio0.58507681
119MP0005409_darkened_coat_color0.56620057
120MP0001943_abnormal_respiration0.56015065
121MP0010769_abnormal_survival0.55691064
122MP0005551_abnormal_eye_electrophysiolog0.55319105
123MP0002090_abnormal_vision0.54962392
124MP0002082_postnatal_lethality0.53800116
125MP0010770_preweaning_lethality0.53800116

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.90863670
2Focal motor seizures (HP:0011153)7.29555988
3Focal seizures (HP:0007359)5.60741317
4Visual hallucinations (HP:0002367)5.04822614
5Epileptic encephalopathy (HP:0200134)4.68902184
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.92561625
7Atonic seizures (HP:0010819)3.84249372
8Febrile seizures (HP:0002373)3.81001319
9Progressive cerebellar ataxia (HP:0002073)3.76634785
10Ankle clonus (HP:0011448)3.67622681
11Absence seizures (HP:0002121)3.62709129
12Abnormal respiratory epithelium morphology (HP:0012253)3.62058175
13Abnormal respiratory motile cilium morphology (HP:0005938)3.62058175
14Impaired vibration sensation in the lower limbs (HP:0002166)3.61171208
15Poor eye contact (HP:0000817)3.49086293
16Generalized tonic-clonic seizures (HP:0002069)3.41200576
17Amblyopia (HP:0000646)3.41136133
18Action tremor (HP:0002345)3.40573224
19Abnormal respiratory motile cilium physiology (HP:0012261)3.39664419
20Broad-based gait (HP:0002136)3.37832080
21Dialeptic seizures (HP:0011146)3.33955176
22Depression (HP:0000716)3.31692053
23Abnormal ciliary motility (HP:0012262)3.31478410
24Supranuclear gaze palsy (HP:0000605)3.31306980
25Abnormal eating behavior (HP:0100738)3.22798739
26Dynein arm defect of respiratory motile cilia (HP:0012255)3.17552328
27Absent/shortened dynein arms (HP:0200106)3.17552328
28Papilledema (HP:0001085)3.17244321
29Abnormality of the lower motor neuron (HP:0002366)3.14698443
30Anxiety (HP:0000739)3.07077721
31Megalencephaly (HP:0001355)3.03282479
32Impaired social interactions (HP:0000735)3.02262352
33Abnormal social behavior (HP:0012433)3.02262352
34Urinary bladder sphincter dysfunction (HP:0002839)3.00702992
35Torticollis (HP:0000473)2.98674254
36Hyperthyroidism (HP:0000836)2.97399454
37Focal dystonia (HP:0004373)2.92438045
38Hyperventilation (HP:0002883)2.91830231
39Mutism (HP:0002300)2.81363412
40Urinary urgency (HP:0000012)2.80014555
41Rhinitis (HP:0012384)2.78631384
42Polyphagia (HP:0002591)2.76645136
43Truncal ataxia (HP:0002078)2.75759380
44Stereotypic behavior (HP:0000733)2.74195546
45Annular pancreas (HP:0001734)2.70403544
46Hyperacusis (HP:0010780)2.67511305
47Dysdiadochokinesis (HP:0002075)2.66787543
48Genetic anticipation (HP:0003743)2.63206614
49Gaze-evoked nystagmus (HP:0000640)2.63022748
50Dysmetria (HP:0001310)2.60635382
51Pointed chin (HP:0000307)2.57761894
52Drooling (HP:0002307)2.56374517
53Excessive salivation (HP:0003781)2.56374517
54Craniofacial dystonia (HP:0012179)2.55640937
55Obstructive sleep apnea (HP:0002870)2.52806298
56Postural instability (HP:0002172)2.49506331
57Abnormality of the aortic arch (HP:0012303)2.49006606
58Sleep apnea (HP:0010535)2.47760270
59Limb dystonia (HP:0002451)2.46487749
60Epileptiform EEG discharges (HP:0011182)2.44310361
61Broad distal phalanx of finger (HP:0009836)2.43493191
62Spastic gait (HP:0002064)2.42482240
63Failure to thrive in infancy (HP:0001531)2.35751607
64Hemiparesis (HP:0001269)2.33223638
65Impaired smooth pursuit (HP:0007772)2.32919500
66EEG with generalized epileptiform discharges (HP:0011198)2.32262911
67Bradykinesia (HP:0002067)2.26582723
68Cerebral inclusion bodies (HP:0100314)2.25932171
69Hypsarrhythmia (HP:0002521)2.25925564
70Overriding aorta (HP:0002623)2.24946429
71Turricephaly (HP:0000262)2.24642070
72Atelectasis (HP:0100750)2.22629398
73Impaired vibratory sensation (HP:0002495)2.22284967
74Elfin facies (HP:0004428)2.20769359
75Absent speech (HP:0001344)2.16939636
76Insomnia (HP:0100785)2.16758736
77Delusions (HP:0000746)2.13285129
78Progressive inability to walk (HP:0002505)2.13008554
79Akinesia (HP:0002304)2.12978665
80Ankyloglossia (HP:0010296)2.10739570
81Chronic bronchitis (HP:0004469)2.10581499
82Hypoventilation (HP:0002791)2.10447557
83Incomplete penetrance (HP:0003829)2.07935553
84Termporal pattern (HP:0011008)2.06372890
85Insidious onset (HP:0003587)2.06372890
86Lower limb muscle weakness (HP:0007340)2.06276902
87Specific learning disability (HP:0001328)2.00515367
88Agitation (HP:0000713)1.99866347
89Scanning speech (HP:0002168)1.99000683
90Aplasia involving bones of the upper limbs (HP:0009823)1.97851106
91Aplasia of the phalanges of the hand (HP:0009802)1.97851106
92Aplasia involving bones of the extremities (HP:0009825)1.97851106
93Inability to walk (HP:0002540)1.97775287
94Neurofibrillary tangles (HP:0002185)1.96982323
95Apathy (HP:0000741)1.96318413
96Amyotrophic lateral sclerosis (HP:0007354)1.96004884
97Abnormality of ocular smooth pursuit (HP:0000617)1.95782652
98Cerebral hypomyelination (HP:0006808)1.93828234
99Fetal akinesia sequence (HP:0001989)1.91628711
100Ventricular fibrillation (HP:0001663)1.89822161
101Abnormality of the corticospinal tract (HP:0002492)1.89275649
102Status epilepticus (HP:0002133)1.89259232
103Renal duplication (HP:0000075)1.87882979
104Abnormality of the diencephalon (HP:0010662)1.87870864
105Deep palmar crease (HP:0006191)1.87558633
106Congenital malformation of the right heart (HP:0011723)1.87325241
107Double outlet right ventricle (HP:0001719)1.87325241
108Abnormality of binocular vision (HP:0011514)1.86501378
109Diplopia (HP:0000651)1.86501378
110Generalized myoclonic seizures (HP:0002123)1.85517318
111Hand muscle atrophy (HP:0009130)1.84638605
112Shoulder girdle muscle weakness (HP:0003547)1.83309578
113Intention tremor (HP:0002080)1.82393252
114Anosmia (HP:0000458)1.82165963
115Hemiplegia (HP:0002301)1.81400498
116Lower limb asymmetry (HP:0100559)1.80672095
117Renovascular hypertension (HP:0100817)1.79901536
118Abnormal EKG (HP:0003115)1.77815639
119Dysmetric saccades (HP:0000641)1.77674540
120Spinal canal stenosis (HP:0003416)1.77588312
121Truncus arteriosus (HP:0001660)1.77370326
122Anomalous pulmonary venous return (HP:0010772)1.76327687
123Clonus (HP:0002169)1.75884969
124Rapidly progressive (HP:0003678)1.75848668
125Nasal polyposis (HP:0100582)1.75819665
126Lower limb amyotrophy (HP:0007210)1.75770828
127Protruding tongue (HP:0010808)1.75378132
128Diminished motivation (HP:0000745)1.75342458
129Neoplasm of the heart (HP:0100544)1.75299304
130Bronchomalacia (HP:0002780)1.74081985
131Lissencephaly (HP:0001339)1.73594868
132Generalized hypotonia (HP:0001290)1.72869087
133Upper limb amyotrophy (HP:0009129)1.69865621
134Distal upper limb amyotrophy (HP:0007149)1.69865621
135Spastic tetraparesis (HP:0001285)1.68909396
136Partial duplication of thumb phalanx (HP:0009944)1.66389802
137Tetraplegia (HP:0002445)1.65993404
138Neuronal loss in central nervous system (HP:0002529)1.63503287
139Long palpebral fissure (HP:0000637)1.63173366
140Rib fusion (HP:0000902)1.61020546
141Asymmetric growth (HP:0100555)1.60993489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.05252816
2MAP3K94.32336023
3NTRK34.20597205
4MARK13.09521417
5MINK12.79058800
6DAPK22.71507679
7MAP3K42.50413888
8KSR22.40212800
9KSR12.39695870
10PAK62.23956752
11NTRK22.23661082
12PRKD32.23602987
13MAP2K72.14256454
14MAP3K121.95065499
15DAPK11.85582880
16CAMKK11.81982911
17ARAF1.81109852
18CDK191.72047753
19MAPK151.69699839
20CDK51.59833648
21RIPK41.57845777
22SIK31.56686518
23TYRO31.55333973
24TRIB31.55151736
25MAP2K41.53378464
26PLK21.51636098
27MAP3K111.50776596
28UHMK11.42399026
29SIK21.41753555
30NTRK11.37849654
31PRPF4B1.36238685
32MAPK131.35638399
33GRK51.31587063
34TNIK1.26740062
35MAP3K131.18782238
36CDK181.15423033
37PRKCG1.13444176
38CASK1.12076689
39RIPK11.11917414
40MAP3K21.10811884
41CDK141.07458303
42CDK151.06651360
43PTK2B1.06378684
44TAOK11.05616391
45FES1.03585685
46PNCK1.03240876
47RAF10.99880589
48TESK10.96614635
49STK380.96008807
50CDK11A0.95665478
51CAMK10.94439850
52CAMKK20.93984805
53SMG10.90594785
54PHKG20.87451448
55PHKG10.87451448
56CAMK1D0.87441621
57LATS20.84542494
58PAK30.82983239
59CAMK2A0.82108419
60BCR0.81016584
61RET0.79578971
62NEK60.78551810
63EEF2K0.78316798
64CAMK2G0.78313118
65STK160.78129981
66SIK10.76296713
67STK110.73167165
68SGK4940.72568168
69SGK2230.72568168
70CAMK2B0.72267601
71MARK20.71392809
72DYRK1A0.71249244
73PKN10.68282294
74CCNB10.65907778
75ERBB30.65761433
76PRKCH0.60078376
77AURKA0.58794946
78FGFR20.58185376
79DAPK30.56761653
80FER0.56535585
81NEK10.55540378
82CSNK1G20.55533817
83BMPR20.55468239
84MAPK120.55112844
85PDK10.54786588
86DMPK0.54745631
87PRKCZ0.54416196
88MAP2K20.54224733
89ROCK20.53979836
90MAP3K10.53961621
91LMTK20.53771209
92PDPK10.52317037
93SGK10.51810863
94ALK0.51261311
95EPHA20.51257784
96LIMK10.50243576
97MAP2K10.49408138
98OXSR10.49275093
99PRKCI0.49207390
100CAMK40.48978137
101BRAF0.46323532
102DYRK1B0.45330006
103SGK20.45090166
104WNK30.44895380
105ERBB20.44819140
106CSNK1E0.44258238
107DYRK20.43595856
108BRSK10.40820092
109PTK20.40027793
110PINK10.39688601
111ICK0.39200983
112FYN0.38640410
113AKT20.38195658
114EPHB20.37960009
115FGR0.37825765
116MAPK80.37438338
117CAMK2D0.36819771
118RPS6KA30.36514219
119IRAK20.36392996
120RPS6KA20.36197114
121SGK30.35920498
122MTOR0.35387338
123ROCK10.35004526
124CAMK1G0.34911768
125NME10.32184404
126MAPK100.32142623
127WNK40.32125199
128PRKCE0.30009474
129CDC42BPA0.28364121
130DDR20.28294824

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.28625447
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26249155
3Olfactory transduction_Homo sapiens_hsa047403.07722894
4Long-term potentiation_Homo sapiens_hsa047202.74754310
5Circadian entrainment_Homo sapiens_hsa047132.74385065
6Amphetamine addiction_Homo sapiens_hsa050312.60354691
7Glutamatergic synapse_Homo sapiens_hsa047242.51503220
8GABAergic synapse_Homo sapiens_hsa047272.49847952
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48960713
10Morphine addiction_Homo sapiens_hsa050322.42000013
11Dopaminergic synapse_Homo sapiens_hsa047282.30575621
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21533513
13Cholinergic synapse_Homo sapiens_hsa047252.04304487
14Salivary secretion_Homo sapiens_hsa049702.02432689
15Insulin secretion_Homo sapiens_hsa049112.00715559
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90666436
17Gastric acid secretion_Homo sapiens_hsa049711.84082783
18Cocaine addiction_Homo sapiens_hsa050301.83932554
19Oxytocin signaling pathway_Homo sapiens_hsa049211.76889764
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71788071
21Renin secretion_Homo sapiens_hsa049241.60452881
22GnRH signaling pathway_Homo sapiens_hsa049121.57969184
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57180158
24Long-term depression_Homo sapiens_hsa047301.57128973
25Vitamin B6 metabolism_Homo sapiens_hsa007501.55666845
26Gap junction_Homo sapiens_hsa045401.55068647
27Serotonergic synapse_Homo sapiens_hsa047261.54216372
28Calcium signaling pathway_Homo sapiens_hsa040201.51091847
29Taste transduction_Homo sapiens_hsa047421.46628217
30Glioma_Homo sapiens_hsa052141.40521176
31Axon guidance_Homo sapiens_hsa043601.38841077
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34159659
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31807395
34Collecting duct acid secretion_Homo sapiens_hsa049661.30251176
35cAMP signaling pathway_Homo sapiens_hsa040241.25696965
36Melanogenesis_Homo sapiens_hsa049161.25452339
37Estrogen signaling pathway_Homo sapiens_hsa049151.21339181
38Notch signaling pathway_Homo sapiens_hsa043301.18507780
39ErbB signaling pathway_Homo sapiens_hsa040121.17996537
40Oocyte meiosis_Homo sapiens_hsa041141.11495017
41Basal cell carcinoma_Homo sapiens_hsa052171.04868799
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01680235
43Type II diabetes mellitus_Homo sapiens_hsa049301.00234693
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99736551
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97585589
46Vibrio cholerae infection_Homo sapiens_hsa051100.95486999
47VEGF signaling pathway_Homo sapiens_hsa043700.94929044
48Nitrogen metabolism_Homo sapiens_hsa009100.92617503
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.90655608
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.90410689
51Cardiac muscle contraction_Homo sapiens_hsa042600.89485661
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89320069
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.86499420
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86299990
55Choline metabolism in cancer_Homo sapiens_hsa052310.81075968
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78139564
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77661863
58Dorso-ventral axis formation_Homo sapiens_hsa043200.74667356
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72991459
60MAPK signaling pathway_Homo sapiens_hsa040100.72619740
61Alcoholism_Homo sapiens_hsa050340.72609535
62Non-small cell lung cancer_Homo sapiens_hsa052230.72310120
63Thyroid hormone synthesis_Homo sapiens_hsa049180.71498082
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70637441
65Endometrial cancer_Homo sapiens_hsa052130.70455994
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69312163
67Dilated cardiomyopathy_Homo sapiens_hsa054140.68152963
68Huntingtons disease_Homo sapiens_hsa050160.67654942
69Rap1 signaling pathway_Homo sapiens_hsa040150.67409563
70Phototransduction_Homo sapiens_hsa047440.67041575
71Sulfur relay system_Homo sapiens_hsa041220.66670008
72Wnt signaling pathway_Homo sapiens_hsa043100.65981325
73Tight junction_Homo sapiens_hsa045300.65180514
74Ras signaling pathway_Homo sapiens_hsa040140.64292743
75Pancreatic secretion_Homo sapiens_hsa049720.63677535
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.61673933
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61509823
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61305931
79Glucagon signaling pathway_Homo sapiens_hsa049220.60836422
80mTOR signaling pathway_Homo sapiens_hsa041500.59494260
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58108185
82Arginine and proline metabolism_Homo sapiens_hsa003300.55996153
83Endocytosis_Homo sapiens_hsa041440.55809141
84Renal cell carcinoma_Homo sapiens_hsa052110.55362464
85Colorectal cancer_Homo sapiens_hsa052100.54382554
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53348412
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52782007
88Prion diseases_Homo sapiens_hsa050200.51672433
89AMPK signaling pathway_Homo sapiens_hsa041520.50388420
90beta-Alanine metabolism_Homo sapiens_hsa004100.49667498
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49326246
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48553386
93Phenylalanine metabolism_Homo sapiens_hsa003600.48323074
94Oxidative phosphorylation_Homo sapiens_hsa001900.47150362
95Insulin signaling pathway_Homo sapiens_hsa049100.46272691
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45807723
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44888219
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44120623
99Parkinsons disease_Homo sapiens_hsa050120.43135469
100Circadian rhythm_Homo sapiens_hsa047100.41910686
101Histidine metabolism_Homo sapiens_hsa003400.41240828
102Type I diabetes mellitus_Homo sapiens_hsa049400.38481148
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36482803
104Chemokine signaling pathway_Homo sapiens_hsa040620.35605273
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33983283
106African trypanosomiasis_Homo sapiens_hsa051430.33613359
107Hippo signaling pathway_Homo sapiens_hsa043900.33501418
108Hedgehog signaling pathway_Homo sapiens_hsa043400.32676567
109Ribosome_Homo sapiens_hsa030100.32454548
110Inositol phosphate metabolism_Homo sapiens_hsa005620.31819875
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30529967
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27842308
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27638766
114Prolactin signaling pathway_Homo sapiens_hsa049170.27337320
115Alzheimers disease_Homo sapiens_hsa050100.26330374
116Bile secretion_Homo sapiens_hsa049760.26177792

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