CTSW

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive thymic T cell selection (GO:0045059)7.71754142
2cellular response to interleukin-15 (GO:0071350)7.62610720
3negative thymic T cell selection (GO:0045060)7.48976537
4negative T cell selection (GO:0043383)7.48884085
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.21819026
6regulation of isotype switching to IgG isotypes (GO:0048302)6.94964346
7thymic T cell selection (GO:0045061)6.93373822
8cytidine deamination (GO:0009972)6.74382209
9cytidine metabolic process (GO:0046087)6.74382209
10cytidine catabolic process (GO:0006216)6.74382209
11sequestering of actin monomers (GO:0042989)6.69643288
12positive regulation of gamma-delta T cell activation (GO:0046645)6.69575228
13response to interleukin-15 (GO:0070672)6.66789608
14interferon-gamma production (GO:0032609)6.60986988
15leukocyte aggregation (GO:0070486)6.60303710
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.54160172
17positive T cell selection (GO:0043368)6.47336967
18pyrimidine ribonucleoside catabolic process (GO:0046133)6.05108913
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.88295153
20T cell migration (GO:0072678)5.79844120
21negative regulation of cell killing (GO:0031342)5.71067025
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.71067025
23T cell selection (GO:0045058)5.67717275
24T cell receptor signaling pathway (GO:0050852)5.65889397
25T cell costimulation (GO:0031295)5.63929598
26regulation of B cell receptor signaling pathway (GO:0050855)5.62672732
27lymphocyte costimulation (GO:0031294)5.60289372
28regulation of gamma-delta T cell differentiation (GO:0045586)5.50631139
29positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.49350497
30positive regulation of natural killer cell mediated immunity (GO:0002717)5.49350497
31regulation of T cell tolerance induction (GO:0002664)5.47564105
32regulation of natural killer cell mediated immunity (GO:0002715)5.46451999
33regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.46451999
34regulation of T cell receptor signaling pathway (GO:0050856)5.34111159
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.18379145
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.91157428
37regulation of gamma-delta T cell activation (GO:0046643)4.90201880
38positive regulation of alpha-beta T cell proliferation (GO:0046641)4.89631203
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.88444961
40antigen receptor-mediated signaling pathway (GO:0050851)4.88187334
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.80280861
42regulation of leukocyte mediated cytotoxicity (GO:0001910)4.73852483
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.63904979
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63904979
45positive regulation of tolerance induction (GO:0002645)4.54524508
46regulation of alpha-beta T cell proliferation (GO:0046640)4.47157209
47regulation of immunoglobulin mediated immune response (GO:0002889)4.47069955
48regulation of activation of Janus kinase activity (GO:0010533)4.46046417
49positive regulation of lamellipodium assembly (GO:0010592)4.43665394
50positive regulation of B cell mediated immunity (GO:0002714)4.38170892
51positive regulation of immunoglobulin mediated immune response (GO:0002891)4.38170892
52regulation of B cell mediated immunity (GO:0002712)4.32281059
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.32195631
54positive regulation of cell killing (GO:0031343)4.26421729
55negative regulation of T cell receptor signaling pathway (GO:0050860)4.24755668
56natural killer cell activation (GO:0030101)4.22219327
57regulation of cell killing (GO:0031341)4.19697950
58negative regulation of T cell apoptotic process (GO:0070233)4.17950173
59DNA deamination (GO:0045006)4.14629365
60negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.08614714
61negative regulation of lymphocyte mediated immunity (GO:0002707)4.08510792
62regulation of T cell mediated cytotoxicity (GO:0001914)3.99633851
63positive regulation of macrophage differentiation (GO:0045651)3.98181056
64regulation of response to interferon-gamma (GO:0060330)3.94478529
65positive regulation of B cell differentiation (GO:0045579)3.93195220
66regulation of tolerance induction (GO:0002643)3.92539985
67regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.88847533
68regulation of type I interferon-mediated signaling pathway (GO:0060338)3.88632511
69positive regulation of isotype switching (GO:0045830)3.88183872
70regulation of isotype switching (GO:0045191)3.87496292
71mast cell activation (GO:0045576)3.85933953
72antigen processing and presentation of endogenous antigen (GO:0019883)3.84472814
73negative regulation of T cell mediated immunity (GO:0002710)3.80295237
74cellular response to zinc ion (GO:0071294)3.79859014
75cellular defense response (GO:0006968)3.78264376
76lymphocyte migration (GO:0072676)3.78027522
77positive regulation of T cell mediated cytotoxicity (GO:0001916)3.73565628
78type I interferon signaling pathway (GO:0060337)3.72449397
79cellular response to type I interferon (GO:0071357)3.72449397
80response to type I interferon (GO:0034340)3.71820019
81positive regulation of defense response to virus by host (GO:0002230)3.71577427
82negative regulation of immunoglobulin mediated immune response (GO:0002890)3.71355157
83negative regulation of B cell mediated immunity (GO:0002713)3.71355157
84regulation of B cell differentiation (GO:0045577)3.70125796
85positive regulation of lamellipodium organization (GO:1902745)3.68636349
86regulation of lymphocyte mediated immunity (GO:0002706)3.67921606
87actin nucleation (GO:0045010)3.67167268
88cellular extravasation (GO:0045123)3.65921645
89negative regulation by host of viral transcription (GO:0043922)3.64564947
90regulation of respiratory burst (GO:0060263)3.61783131
91antigen processing and presentation via MHC class Ib (GO:0002475)3.57955853
92granulocyte activation (GO:0036230)3.57655039
93regulation of regulatory T cell differentiation (GO:0045589)3.56085770
94positive regulation of lymphocyte mediated immunity (GO:0002708)3.52321911
95neutrophil activation (GO:0042119)3.51343432
96positive regulation of response to tumor cell (GO:0002836)3.51058426
97positive regulation of immune response to tumor cell (GO:0002839)3.51058426
98regulation of immune response to tumor cell (GO:0002837)3.51058426
99regulation of response to tumor cell (GO:0002834)3.51058426
100leukocyte cell-cell adhesion (GO:0007159)3.46397083
101positive regulation of DNA recombination (GO:0045911)3.43614437
102negative regulation of leukocyte mediated immunity (GO:0002704)3.40213240
103Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40161326
104regulation of immunoglobulin production (GO:0002637)3.39292012
105positive regulation of calcium-mediated signaling (GO:0050850)3.38927552
106lymphocyte chemotaxis (GO:0048247)3.38015149
107immune response-activating cell surface receptor signaling pathway (GO:0002429)3.37560961
108leukocyte degranulation (GO:0043299)3.35049763
109T cell activation (GO:0042110)3.35045957
110pyrimidine nucleoside catabolic process (GO:0046135)3.33030987
111T cell differentiation (GO:0030217)3.32682388
112negative regulation of viral genome replication (GO:0045071)3.32191783
113positive regulation of immunoglobulin production (GO:0002639)3.31545151
114mucosal-associated lymphoid tissue development (GO:0048537)3.31389493
115Peyers patch development (GO:0048541)3.31389493
116negative regulation of lymphocyte apoptotic process (GO:0070229)3.27039734
117negative regulation of type 2 immune response (GO:0002829)3.26015593
118positive regulation of interleukin-8 secretion (GO:2000484)3.25956970
119activated T cell proliferation (GO:0050798)3.25590508
120immunoglobulin mediated immune response (GO:0016064)3.24185016
121cellular response to interleukin-4 (GO:0071353)3.23818891
122negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.22938577
123dendritic cell chemotaxis (GO:0002407)3.22008323
124regulation of lymphocyte chemotaxis (GO:1901623)3.20587321
125positive regulation of T cell mediated immunity (GO:0002711)3.19942705
126positive regulation of lymphocyte migration (GO:2000403)3.13093141
127regulation of T cell chemotaxis (GO:0010819)3.11230485
128positive regulation of T cell chemotaxis (GO:0010820)3.11230485
129mast cell activation involved in immune response (GO:0002279)3.09293995
130mast cell degranulation (GO:0043303)3.09293995
131neutrophil activation involved in immune response (GO:0002283)3.07770254
132negative regulation of innate immune response (GO:0045824)3.06260611
133positive regulation of granulocyte differentiation (GO:0030854)3.02292304
134regulation of T cell mediated immunity (GO:0002709)3.01783640
135regulation of T cell apoptotic process (GO:0070232)3.01592172
136response to interferon-beta (GO:0035456)3.00122830
137B cell mediated immunity (GO:0019724)2.99361461
138regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97179721
139macrophage chemotaxis (GO:0048246)2.93690167
140cytolysis (GO:0019835)2.93194471
141regulation of memory T cell differentiation (GO:0043380)2.92888210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.79203650
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.08899579
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.48128386
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.32873610
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.06860513
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.06605040
7* STAT4_19710469_ChIP-ChIP_TH1__Mouse4.01849325
8RUNX_20019798_ChIP-Seq_JUKART_Human3.43603156
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.34869835
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.33517376
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22851245
12MYB_26560356_Chip-Seq_TH2_Human3.22759178
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.17438780
14MAF_26560356_Chip-Seq_TH1_Human3.10529229
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.00346128
16* UTX_26944678_Chip-Seq_JUKART_Human2.84736880
17* MYB_26560356_Chip-Seq_TH1_Human2.79442658
18MYC_22102868_ChIP-Seq_BL_Human2.68863099
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.46660410
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.43013331
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.42996615
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.41157398
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32554022
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.29989136
25GATA3_27048872_Chip-Seq_THYMUS_Human2.13819413
26MAF_26560356_Chip-Seq_TH2_Human2.10825766
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05716283
28SPI1_23547873_ChIP-Seq_NB4_Human2.03675686
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93779112
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86835124
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86292567
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76457495
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74012209
34VDR_21846776_ChIP-Seq_THP-1_Human1.72673085
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69913277
36SCL_19346495_ChIP-Seq_HPC-7_Human1.66170631
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.64242017
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62972556
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57780650
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54558791
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49844645
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44085726
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42969996
44E2F7_22180533_ChIP-Seq_HELA_Human1.42422876
45GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40815635
46VDR_24763502_ChIP-Seq_THP-1_Human1.40193834
47* BCL6_27268052_Chip-Seq_Bcells_Human1.39566342
48GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37968985
49TCF7_22412390_ChIP-Seq_EML_Mouse1.36784192
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34811584
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30625575
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29757363
53GATA3_26560356_Chip-Seq_TH2_Human1.29280760
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24241735
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23365224
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23205440
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22242682
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21815901
59VDR_23849224_ChIP-Seq_CD4+_Human1.20712983
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20007560
61SPI1_23127762_ChIP-Seq_K562_Human1.19202620
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16417959
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15117779
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15088931
65KDM2B_26808549_Chip-Seq_DND41_Human1.13939057
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12498974
67P300_27268052_Chip-Seq_Bcells_Human1.08772375
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.08567648
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07620078
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07000885
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06149702
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06140271
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05754410
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05646633
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05429800
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03674067
77PU_27001747_Chip-Seq_BMDM_Mouse1.02659798
78SPI1_20517297_ChIP-Seq_HL60_Human1.02459143
79* BCOR_27268052_Chip-Seq_Bcells_Human1.01447858
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.00707922
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98861170
82FOXP3_21729870_ChIP-Seq_TREG_Human0.98596106
83GATA3_26560356_Chip-Seq_TH1_Human0.97769435
84GATA1_22025678_ChIP-Seq_K562_Human0.96990945
85* ELK3_25401928_ChIP-Seq_HUVEC_Human0.96633806
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94545341
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91789895
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89960619
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89898624
90NANOG_20526341_ChIP-Seq_ESCs_Human0.89446902
91KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89058151
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88543176
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88094294
94SRF_21415370_ChIP-Seq_HL-1_Mouse0.88057484
95TAF2_19829295_ChIP-Seq_ESCs_Human0.87478135
96LXR_22292898_ChIP-Seq_THP-1_Human0.87319111
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87164439
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.85944694
99GATA1_19941826_ChIP-Seq_K562_Human0.85798704
100STAT1_20625510_ChIP-Seq_HELA_Human0.83954845
101IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82187932
102GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82005574
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81579462
104RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80126997
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79441932
106RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78610608
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78432257
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78212326
109IRF1_19129219_ChIP-ChIP_H3396_Human0.77760386
110* FLI1_21867929_ChIP-Seq_CD8_Mouse0.77646696
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77608764
112VDR_24787735_ChIP-Seq_THP-1_Human0.77537667
113SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76564919
114GABP_17652178_ChIP-ChIP_JURKAT_Human0.74418487
115CTCF_20526341_ChIP-Seq_ESCs_Human0.74184541
116* SA1_27219007_Chip-Seq_Bcells_Human0.73947681
117GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73849056
118E2F1_20622854_ChIP-Seq_HELA_Human0.73555188
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73011033
120PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72290261
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.70497568
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70044561
123CTCF_26484167_Chip-Seq_Bcells_Mouse0.69210237
124CIITA_25753668_ChIP-Seq_RAJI_Human0.68984028
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67891588
126JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.67346271
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.65348044
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.63413688
129ELK1_19687146_ChIP-ChIP_HELA_Human0.62727029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.14863128
2MP0003763_abnormal_thymus_physiology5.73304532
3MP0009785_altered_susceptibility_to4.21282628
4MP0006082_CNS_inflammation3.80388077
5MP0002166_altered_tumor_susceptibility3.61134408
6MP0001835_abnormal_antigen_presentation3.49636950
7MP0000685_abnormal_immune_system3.18139507
8MP0001800_abnormal_humoral_immune3.11868795
9MP0002006_tumorigenesis3.10831109
10MP0005025_abnormal_response_to3.05515797
11MP0002420_abnormal_adaptive_immunity3.02553584
12MP0001819_abnormal_immune_cell3.01214118
13MP0005000_abnormal_immune_tolerance2.91382492
14MP0002723_abnormal_immune_serum2.90459628
15MP0002398_abnormal_bone_marrow2.80074854
16MP0001790_abnormal_immune_system2.77493657
17MP0005387_immune_system_phenotype2.77493657
18MP0003724_increased_susceptibility_to2.71784456
19MP0002405_respiratory_system_inflammati2.63894684
20MP0009333_abnormal_splenocyte_physiolog2.58381441
21MP0002452_abnormal_antigen_presenting2.55746082
22MP0000703_abnormal_thymus_morphology2.48855917
23MP0004947_skin_inflammation2.48667894
24MP0000716_abnormal_immune_system2.48434460
25MP0002722_abnormal_immune_system2.41388618
26MP0000689_abnormal_spleen_morphology2.19088677
27MP0002933_joint_inflammation2.18205315
28MP0001873_stomach_inflammation2.10294736
29MP0010155_abnormal_intestine_physiology2.09852742
30MP0002429_abnormal_blood_cell1.97088875
31MP0002419_abnormal_innate_immunity1.93042902
32MP0000858_altered_metastatic_potential1.92308299
33MP0002148_abnormal_hypersensitivity_rea1.83953145
34MP0003436_decreased_susceptibility_to1.81103353
35MP0003866_abnormal_defecation1.74098209
36MP0002396_abnormal_hematopoietic_system1.72289259
37MP0003448_altered_tumor_morphology1.71261946
38MP0004381_abnormal_hair_follicle1.67636140
39MP0001845_abnormal_inflammatory_respons1.67427468
40MP0005464_abnormal_platelet_physiology1.61245541
41MP0002009_preneoplasia1.60975457
42MP0004510_myositis1.56198471
43MP0005310_abnormal_salivary_gland1.51419543
44MP0002132_abnormal_respiratory_system1.46980213
45MP0001851_eye_inflammation1.42886076
46MP0008469_abnormal_protein_level1.30835916
47MP0003300_gastrointestinal_ulcer1.30067520
48MP0002019_abnormal_tumor_incidence1.19663654
49MP0003045_fibrosis1.19290716
50MP0001853_heart_inflammation1.08163423
51MP0002998_abnormal_bone_remodeling1.05467062
52MP0000490_abnormal_crypts_of1.03876576
53MP0009763_increased_sensitivity_to1.00862112
54MP0001533_abnormal_skeleton_physiology0.99242458
55MP0001986_abnormal_taste_sensitivity0.96711724
56MP0009764_decreased_sensitivity_to0.92658895
57MP0002277_abnormal_respiratory_mucosa0.88896486
58MP0003183_abnormal_peptide_metabolism0.87786485
59MP0003786_premature_aging0.81546431
60MP0010234_abnormal_vibrissa_follicle0.81528959
61MP0005075_abnormal_melanosome_morpholog0.81451186
62MP0008872_abnormal_physiological_respon0.80382404
63MP0005023_abnormal_wound_healing0.80303233
64MP0003075_altered_response_to0.78891110
65MP0002876_abnormal_thyroid_physiology0.78772329
66MP0000343_altered_response_to0.77452317
67MP0001765_abnormal_ion_homeostasis0.77190906
68MP0001905_abnormal_dopamine_level0.73962796
69MP0008877_abnormal_DNA_methylation0.73864987
70MP0005451_abnormal_body_composition0.72480536
71MP0000477_abnormal_intestine_morphology0.70904474
72MP0003303_peritoneal_inflammation0.68848055
73MP0001501_abnormal_sleep_pattern0.68744999
74MP0002095_abnormal_skin_pigmentation0.68028355
75MP0009765_abnormal_xenobiotic_induced0.67139231
76MP0001191_abnormal_skin_condition0.66975347
77MP0003878_abnormal_ear_physiology0.65853074
78MP0005377_hearing/vestibular/ear_phenot0.65853074
79MP0003806_abnormal_nucleotide_metabolis0.65235566
80MP0004808_abnormal_hematopoietic_stem0.64025464
81MP0000465_gastrointestinal_hemorrhage0.63636490
82MP0005410_abnormal_fertilization0.62468046
83MP0004145_abnormal_muscle_electrophysio0.60974301
84MP0005083_abnormal_biliary_tract0.60863029
85MP0000015_abnormal_ear_pigmentation0.60771437
86MP0008007_abnormal_cellular_replicative0.60553521
87MP0001243_abnormal_dermal_layer0.60345020
88MP0001881_abnormal_mammary_gland0.60176250
89MP0002138_abnormal_hepatobiliary_system0.58998369
90MP0005166_decreased_susceptibility_to0.57785203
91MP0003638_abnormal_response/metabolism_0.57694832
92MP0001348_abnormal_lacrimal_gland0.57266711
93MP0001919_abnormal_reproductive_system0.56888374
94MP0005084_abnormal_gallbladder_morpholo0.56439983
95MP0003252_abnormal_bile_duct0.55925870
96MP0005645_abnormal_hypothalamus_physiol0.55463012
97MP0002136_abnormal_kidney_physiology0.54525565
98MP0004130_abnormal_muscle_cell0.54166674
99MP0009278_abnormal_bone_marrow0.52705748
100MP0006036_abnormal_mitochondrial_physio0.51940484
101MP0002163_abnormal_gland_morphology0.51549877
102MP0004147_increased_porphyrin_level0.51525954
103MP0003646_muscle_fatigue0.50763286
104MP0000613_abnormal_salivary_gland0.49274276
105MP0001216_abnormal_epidermal_layer0.48361851
106MP0000609_abnormal_liver_physiology0.47513930
107MP0003795_abnormal_bone_structure0.47360910
108MP0001663_abnormal_digestive_system0.46970517
109MP0002909_abnormal_adrenal_gland0.45787081
110MP0003453_abnormal_keratinocyte_physiol0.42594183
111MP0002928_abnormal_bile_duct0.41984416
112MP0000367_abnormal_coat/_hair0.40943109
113MP0002693_abnormal_pancreas_physiology0.40844712
114MP0000372_irregular_coat_pigmentation0.39602690
115MP0000249_abnormal_blood_vessel0.37815986
116MP0000920_abnormal_myelination0.37488548
117MP0004957_abnormal_blastocyst_morpholog0.37184317
118MP0001545_abnormal_hematopoietic_system0.37036678
119MP0005397_hematopoietic_system_phenotyp0.37036678
120MP0009643_abnormal_urine_homeostasis0.36974973
121MP0005174_abnormal_tail_pigmentation0.33743676
122MP0002083_premature_death0.33392593
123MP0003943_abnormal_hepatobiliary_system0.33296747
124MP0008873_increased_physiological_sensi0.31504995
125MP0000627_abnormal_mammary_gland0.31424120
126MP0003959_abnormal_lean_body0.31300603
127MP0005390_skeleton_phenotype0.30501147
128MP0000313_abnormal_cell_death0.28817958

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)7.75365941
2T lymphocytopenia (HP:0005403)7.41380099
3Abnormality of T cell number (HP:0011839)7.32332212
4Combined immunodeficiency (HP:0005387)6.89073370
5Autoimmune hemolytic anemia (HP:0001890)6.47728786
6Elevated erythrocyte sedimentation rate (HP:0003565)6.13973638
7Stomatitis (HP:0010280)5.83164665
8Recurrent bronchitis (HP:0002837)5.51827733
9Hypoplasia of the thymus (HP:0000778)5.50871126
10Thyroiditis (HP:0100646)5.44732877
11Chronic mucocutaneous candidiasis (HP:0002728)5.29771748
12Recurrent cutaneous fungal infections (HP:0011370)5.29771748
13Abnormality of T cells (HP:0002843)5.12373381
14IgG deficiency (HP:0004315)5.11590484
15Chronic diarrhea (HP:0002028)4.76554547
16Myositis (HP:0100614)4.57773605
17Recurrent fungal infections (HP:0002841)4.29646831
18Abnormality of eosinophils (HP:0001879)4.28114781
19Lymphopenia (HP:0001888)4.13779471
20Abnormality of cells of the lymphoid lineage (HP:0012140)4.04134758
21Increased IgM level (HP:0003496)4.00827409
22IgM deficiency (HP:0002850)3.85160273
23Nasal polyposis (HP:0100582)3.80460770
24Optic neuritis (HP:0100653)3.78813121
25Retrobulbar optic neuritis (HP:0100654)3.78813121
26Eczematoid dermatitis (HP:0000976)3.78628306
27Leukocytosis (HP:0001974)3.69972371
28Agammaglobulinemia (HP:0004432)3.62134433
29Orchitis (HP:0100796)3.60524634
30Recurrent abscess formation (HP:0002722)3.59706332
31Aplastic anemia (HP:0001915)3.41728919
32Panhypogammaglobulinemia (HP:0003139)3.36251622
33Joint swelling (HP:0001386)3.36230366
34Abnormality of the nasal mucosa (HP:0000433)3.18037742
35Abnormality of T cell physiology (HP:0011840)3.12191709
36Prolonged bleeding time (HP:0003010)3.10666196
37Petechiae (HP:0000967)3.07569523
38Bronchitis (HP:0012387)3.04430195
39Recurrent skin infections (HP:0001581)3.03431340
40Chronic otitis media (HP:0000389)3.02547916
41Gastrointestinal infarctions (HP:0005244)2.96121927
42Meningitis (HP:0001287)2.95528139
43Recurrent sinusitis (HP:0011108)2.92712907
44Hemoptysis (HP:0002105)2.92508647
45Obstructive lung disease (HP:0006536)2.92499221
46Chronic obstructive pulmonary disease (HP:0006510)2.92499221
47Mediastinal lymphadenopathy (HP:0100721)2.84777296
48Pustule (HP:0200039)2.84114081
49Recurrent viral infections (HP:0004429)2.83225467
50Hemiplegia (HP:0002301)2.75945775
51Vasculitis (HP:0002633)2.73084523
52Muscle fiber atrophy (HP:0100295)2.69037229
53Keratoconjunctivitis sicca (HP:0001097)2.68836479
54Hypergammaglobulinemia (HP:0010702)2.68197293
55Pulmonary infiltrates (HP:0002113)2.66271533
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.64971819
57B lymphocytopenia (HP:0010976)2.55803612
58Abnormality of B cell number (HP:0010975)2.55803612
59Encephalitis (HP:0002383)2.55470550
60Recurrent otitis media (HP:0000403)2.55034160
61Hypoproteinemia (HP:0003075)2.54884470
62Lymphoma (HP:0002665)2.54306063
63Gingivitis (HP:0000230)2.47214886
64Eosinophilia (HP:0001880)2.46504691
65Renal cortical cysts (HP:0000803)2.41364153
66Keratoconjunctivitis (HP:0001096)2.41324284
67Microcytic anemia (HP:0001935)2.38821196
68Purpura (HP:0000979)2.35673952
69Type 2 muscle fiber atrophy (HP:0003554)2.35605038
70Gangrene (HP:0100758)2.32079906
71Aplasia/Hypoplasia of the thymus (HP:0010515)2.31455541
72Gingival bleeding (HP:0000225)2.26137050
73Increased serum ferritin (HP:0003281)2.23667643
74Arterial thrombosis (HP:0004420)2.21958322
753-Methylglutaconic aciduria (HP:0003535)2.21638792
76Alveolar cell carcinoma (HP:0006519)2.20620483
77Amyotrophic lateral sclerosis (HP:0007354)2.18428627
78Entropion (HP:0000621)2.15342864
79Poikiloderma (HP:0001029)2.13080431
80Acute hepatic failure (HP:0006554)2.11581423
81Abnormality of iron homeostasis (HP:0011031)2.10305070
82Abnormality of the fingertips (HP:0001211)2.09385277
83Granulocytopenia (HP:0001913)2.08889697
84Cheilitis (HP:0100825)2.08510324
85Reduced subcutaneous adipose tissue (HP:0003758)2.07265428
86Pulmonary embolism (HP:0002204)2.06094661
87Skin rash (HP:0000988)2.04888684
88Pulmonary fibrosis (HP:0002206)2.03815290
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03177946
90Hypochromic anemia (HP:0001931)2.00637835
91Urticaria (HP:0001025)1.99396663
92Autoimmune thrombocytopenia (HP:0001973)1.99317084
93Abnormality of transition element cation homeostasis (HP:0011030)1.98586862
94Stomach cancer (HP:0012126)1.98243053
95Episodic fever (HP:0001954)1.97691151
96Anorexia (HP:0002039)1.97567039
97Inflammation of the large intestine (HP:0002037)1.94219817
98Abolished electroretinogram (ERG) (HP:0000550)1.92832283
99Abnormality of the prostate (HP:0008775)1.92770241
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90727671
101Epistaxis (HP:0000421)1.90435668
102Pancytopenia (HP:0001876)1.86680433
103Vertigo (HP:0002321)1.86440780
104Glomerulopathy (HP:0100820)1.85920964
105Ureteral stenosis (HP:0000071)1.85487751
106Gastrointestinal inflammation (HP:0004386)1.85403379
107Neoplasm of the tracheobronchial system (HP:0100552)1.84847694
108Abnormality of the heme biosynthetic pathway (HP:0010472)1.84687863
109Sepsis (HP:0100806)1.83433896
110Recurrent bacterial skin infections (HP:0005406)1.82453861
111Hepatosplenomegaly (HP:0001433)1.81115446
112IgA deficiency (HP:0002720)1.78557075
113Basal cell carcinoma (HP:0002671)1.78461270
114Premature graying of hair (HP:0002216)1.77881259
115Keratitis (HP:0000491)1.77592031
116Anhidrosis (HP:0000970)1.77473320
117Large eyes (HP:0001090)1.76910504
118Hypoalbuminemia (HP:0003073)1.74167678
119Abnormal albumin level (HP:0012116)1.74167678
120Abnormality of the pleura (HP:0002103)1.74108678
121Abnormality of oral frenula (HP:0000190)1.73521767
122Recurrent gram-negative bacterial infections (HP:0005420)1.71954467
123Spontaneous hematomas (HP:0007420)1.71636320
124Thrombocytosis (HP:0001894)1.70853551
125Increased IgE level (HP:0003212)1.70148816
126Abnormality of macrophages (HP:0004311)1.69638967
127Chest pain (HP:0100749)1.69279120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.02295680
2MAP4K14.88334488
3KDR4.65920991
4IKBKE3.50526111
5TESK23.42336156
6TAOK33.41810141
7ZAP703.37457991
8FGFR43.34598106
9ITK3.33070649
10BCKDK2.81816410
11TYK22.64479389
12JAK32.62728350
13TBK12.54425462
14MAP3K122.25133360
15JAK12.24178910
16RIPK42.19828112
17LCK2.18653015
18BLK1.87473615
19TEC1.83309337
20KIT1.80649489
21FGFR31.71047777
22MAP3K141.62860494
23STK101.62469241
24NME21.61722648
25MAP4K21.53372080
26BTK1.52195346
27TLK11.51581624
28MST41.42533365
29CSK1.42214627
30SYK1.41824907
31BMPR21.40553219
32GRK61.33002610
33TESK11.30493870
34HCK1.28075949
35NUAK11.28048711
36IRAK41.24264013
37MATK1.13975445
38LYN1.09400469
39MAP2K61.08932963
40PRKCH1.08208678
41PRKCQ1.06527836
42MARK31.05452163
43VRK21.05186440
44MAP3K131.03026929
45CLK11.02045032
46NLK0.98744080
47PIK3CG0.95892785
48MAP2K20.95849371
49LRRK20.94680895
50TNK20.94091064
51BUB10.84707327
52IKBKB0.78861771
53FYN0.77544389
54ZAK0.77263154
55CAMKK20.75912423
56NEK90.74522057
57ACVR1B0.73993053
58FGFR10.69352048
59MYLK0.67366729
60MAPK110.67079665
61PIK3CA0.66971831
62CDK30.66388652
63RPS6KA40.64743397
64TAOK10.63221529
65DAPK30.61077024
66INSR0.59446074
67LIMK10.57987491
68IGF1R0.57625034
69GRK50.50047345
70CSF1R0.49960364
71FES0.49659358
72MUSK0.49093198
73SCYL20.48028404
74GRK10.47427810
75EEF2K0.46885578
76BRD40.46728920
77JAK20.46480111
78MAPKAPK20.45040156
79VRK10.44457470
80PIM10.43092008
81TGFBR20.42290269
82MAP3K100.42187881
83ADRBK10.41225485
84ERN10.39865191
85EIF2AK20.37832544
86ADRBK20.37282478
87MAPK130.36042592
88PRKCD0.35542825
89MAP3K70.34366726
90EPHA30.34162820
91PRKG20.32102659
92EPHB10.31967776
93ROCK10.30796036
94CDK40.30783208
95PINK10.30446445
96FGR0.30414242
97CHUK0.30035997
98TYRO30.29835090
99RPS6KA50.28809455
100ABL10.28563166
101DAPK20.25908058
102MAPK70.25813274
103GRK70.25681541
104MARK20.25137706
105MAP3K110.23996705
106DAPK10.23831508
107SRC0.23312245
108MAPKAPK30.23175780
109ILK0.22848253
110PRKD20.22193807
111STK160.22111869
112WNK40.21710293
113MAP2K30.21648774
114CDK90.21514792
115PIM20.21493849
116PTK2B0.20545715
117RAF10.19494524
118PASK0.18880742
119MAPK120.18617053
120PRKCA0.18484973
121TGFBR10.18313029
122HIPK20.18022838
123FGFR20.17031235
124FRK0.15804506
125PRKD10.15407148
126CSNK1G30.14973863
127SIK20.14926459
128TAOK20.14909124
129TNIK0.14826957
130INSRR0.14553121
131PDGFRB0.14422488
132AURKB0.13911347
133MAPK30.13639906
134PDK10.13593113
135SIK30.13471981
136CSNK1A10.11517129

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.30572649
2Graft-versus-host disease_Homo sapiens_hsa053326.10720675
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.59886290
4Antigen processing and presentation_Homo sapiens_hsa046123.96357210
5T cell receptor signaling pathway_Homo sapiens_hsa046603.49304379
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.26324774
7Measles_Homo sapiens_hsa051622.99135951
8Hematopoietic cell lineage_Homo sapiens_hsa046402.71970096
9Allograft rejection_Homo sapiens_hsa053302.62136901
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.09619939
11Viral myocarditis_Homo sapiens_hsa054162.08558212
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.00698001
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99340409
14Leishmaniasis_Homo sapiens_hsa051401.85412956
15Autoimmune thyroid disease_Homo sapiens_hsa053201.76495491
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61115229
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.55466678
18Ribosome_Homo sapiens_hsa030101.42849575
19Osteoclast differentiation_Homo sapiens_hsa043801.37813487
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32707542
21B cell receptor signaling pathway_Homo sapiens_hsa046621.32507623
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32286208
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28636477
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.26299036
25Proteasome_Homo sapiens_hsa030501.25612103
26Herpes simplex infection_Homo sapiens_hsa051681.18738324
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18137227
28Malaria_Homo sapiens_hsa051441.16288024
29Chemokine signaling pathway_Homo sapiens_hsa040621.14452358
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12009982
31HTLV-I infection_Homo sapiens_hsa051661.07243910
32Type I diabetes mellitus_Homo sapiens_hsa049401.07185124
33Shigellosis_Homo sapiens_hsa051311.06544547
34Asthma_Homo sapiens_hsa053101.03427474
35Nucleotide excision repair_Homo sapiens_hsa034200.94324761
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92378533
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91231849
38DNA replication_Homo sapiens_hsa030300.87273807
39Other glycan degradation_Homo sapiens_hsa005110.82988260
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81601584
41VEGF signaling pathway_Homo sapiens_hsa043700.79926261
42Hepatitis B_Homo sapiens_hsa051610.79399985
43Toxoplasmosis_Homo sapiens_hsa051450.77875967
44Staphylococcus aureus infection_Homo sapiens_hsa051500.76016527
45Phototransduction_Homo sapiens_hsa047440.75392912
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73861794
47Linoleic acid metabolism_Homo sapiens_hsa005910.73776408
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70932119
49African trypanosomiasis_Homo sapiens_hsa051430.70690677
50p53 signaling pathway_Homo sapiens_hsa041150.70291774
51Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69412523
52Mismatch repair_Homo sapiens_hsa034300.67776127
53Influenza A_Homo sapiens_hsa051640.65817873
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65758403
55Nitrogen metabolism_Homo sapiens_hsa009100.65587149
56Oxidative phosphorylation_Homo sapiens_hsa001900.64564768
57Pancreatic cancer_Homo sapiens_hsa052120.63939595
58Arachidonic acid metabolism_Homo sapiens_hsa005900.63684661
59RNA polymerase_Homo sapiens_hsa030200.62968307
60Parkinsons disease_Homo sapiens_hsa050120.62312490
61Spliceosome_Homo sapiens_hsa030400.57526267
62Salmonella infection_Homo sapiens_hsa051320.56485518
63* Apoptosis_Homo sapiens_hsa042100.55281740
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55233318
65Legionellosis_Homo sapiens_hsa051340.54576017
66Regulation of autophagy_Homo sapiens_hsa041400.53462350
67Platelet activation_Homo sapiens_hsa046110.52516962
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52477568
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52018890
70Epstein-Barr virus infection_Homo sapiens_hsa051690.51944706
71TNF signaling pathway_Homo sapiens_hsa046680.51020030
72Sulfur metabolism_Homo sapiens_hsa009200.49629405
73Hepatitis C_Homo sapiens_hsa051600.49574778
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49358030
75Colorectal cancer_Homo sapiens_hsa052100.48938672
76Viral carcinogenesis_Homo sapiens_hsa052030.47504464
77Tuberculosis_Homo sapiens_hsa051520.47461851
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45139644
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43459072
80Systemic lupus erythematosus_Homo sapiens_hsa053220.41878234
81Protein export_Homo sapiens_hsa030600.41775003
82Sulfur relay system_Homo sapiens_hsa041220.41084221
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41073841
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38932454
85Pyrimidine metabolism_Homo sapiens_hsa002400.38737449
86Peroxisome_Homo sapiens_hsa041460.37411822
87Endocytosis_Homo sapiens_hsa041440.37342296
88Rheumatoid arthritis_Homo sapiens_hsa053230.36495681
89Adherens junction_Homo sapiens_hsa045200.36026146
90RNA degradation_Homo sapiens_hsa030180.35514776
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35290941
92Rap1 signaling pathway_Homo sapiens_hsa040150.33605539
93Phagosome_Homo sapiens_hsa041450.33121414
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32498442
95Caffeine metabolism_Homo sapiens_hsa002320.32332012
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.31807578
97Base excision repair_Homo sapiens_hsa034100.31163539
98Pentose phosphate pathway_Homo sapiens_hsa000300.30398783
99Acute myeloid leukemia_Homo sapiens_hsa052210.29676178
100Olfactory transduction_Homo sapiens_hsa047400.28779621
101Pertussis_Homo sapiens_hsa051330.26303952
102Basal transcription factors_Homo sapiens_hsa030220.23226826
103Alzheimers disease_Homo sapiens_hsa050100.21303272
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.18112684
105Prolactin signaling pathway_Homo sapiens_hsa049170.17695858
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15525276
107Non-small cell lung cancer_Homo sapiens_hsa052230.14585313
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14370696
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.14015314
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.13227201
111Chemical carcinogenesis_Homo sapiens_hsa052040.12850397
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.11391123
113Purine metabolism_Homo sapiens_hsa002300.11287241
114Non-homologous end-joining_Homo sapiens_hsa034500.10728358
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10266975
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.09744688
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.09248829
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09171688
119Fanconi anemia pathway_Homo sapiens_hsa034600.07117432
120Collecting duct acid secretion_Homo sapiens_hsa049660.07012838
121* Lysosome_Homo sapiens_hsa041420.06446817
122Homologous recombination_Homo sapiens_hsa034400.06342058
123Sphingolipid metabolism_Homo sapiens_hsa006000.05528382
124Notch signaling pathway_Homo sapiens_hsa043300.04456356
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.01456325
126Ras signaling pathway_Homo sapiens_hsa040140.00827259
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.00637821
128Pathways in cancer_Homo sapiens_hsa052000.00141398
129Focal adhesion_Homo sapiens_hsa045100.00037841
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0351922
131Bladder cancer_Homo sapiens_hsa05219-0.0308058
132Thyroid cancer_Homo sapiens_hsa05216-0.0225419
133Small cell lung cancer_Homo sapiens_hsa05222-0.0212998

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