CTSS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.78555050
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.78555050
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.78555050
4modulation by symbiont of host immune response (GO:0052553)6.78555050
5positive regulation by symbiont of host defense response (GO:0052509)6.78555050
6modulation by symbiont of host defense response (GO:0052031)6.78555050
7neutrophil activation involved in immune response (GO:0002283)6.35077751
8macrophage activation involved in immune response (GO:0002281)5.75245818
9regulation of interferon-beta biosynthetic process (GO:0045357)5.74522796
10microglial cell activation (GO:0001774)5.37270812
11positive regulation of interferon-alpha production (GO:0032727)5.20283140
12detection of other organism (GO:0098543)5.10675878
13immunoglobulin mediated immune response (GO:0016064)5.06751892
14regulation of interferon-alpha production (GO:0032647)4.90423071
15respiratory burst (GO:0045730)4.86302783
16* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.82899709
17response to peptidoglycan (GO:0032494)4.72480963
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.63572488
19detection of bacterium (GO:0016045)4.62043984
20detection of external biotic stimulus (GO:0098581)4.59201014
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55868397
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.44782811
23response to host immune response (GO:0052572)4.44782811
24granulocyte activation (GO:0036230)4.38113534
25regulation of gamma-delta T cell activation (GO:0046643)4.37294682
26macrophage activation (GO:0042116)4.35948365
27neutrophil activation (GO:0042119)4.32768447
28myeloid cell activation involved in immune response (GO:0002275)4.21674804
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.13258778
30positive regulation of antigen processing and presentation (GO:0002579)4.12708001
31detection of biotic stimulus (GO:0009595)4.11970567
32regulation of B cell receptor signaling pathway (GO:0050855)4.05546601
33hydrogen peroxide biosynthetic process (GO:0050665)4.00215098
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.98484260
35response to host (GO:0075136)3.98484260
36response to host defenses (GO:0052200)3.98484260
37production of molecular mediator involved in inflammatory response (GO:0002532)3.87598758
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.86791388
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79805317
40positive regulation of monocyte chemotaxis (GO:0090026)3.79391893
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.79360552
42positive regulation of cellular amide metabolic process (GO:0034250)3.77565276
43regulation of mononuclear cell migration (GO:0071675)3.75902470
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.74702382
45regulation of gamma-delta T cell differentiation (GO:0045586)3.72977956
46positive regulation of interferon-beta production (GO:0032728)3.72530412
47B cell mediated immunity (GO:0019724)3.69066328
48superoxide anion generation (GO:0042554)3.66824128
49positive regulation of mast cell activation (GO:0033005)3.62070735
50leukocyte aggregation (GO:0070486)3.59746891
51negative regulation of T cell mediated immunity (GO:0002710)3.56500332
52positive regulation of mast cell degranulation (GO:0043306)3.54016448
53positive regulation of mast cell activation involved in immune response (GO:0033008)3.54016448
54positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.53696844
55positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.51680713
56reactive oxygen species biosynthetic process (GO:1903409)3.51291885
57regulation of antigen processing and presentation (GO:0002577)3.48338654
58regulation of mast cell degranulation (GO:0043304)3.46685418
59regulation of tolerance induction (GO:0002643)3.43563360
60antigen processing and presentation via MHC class Ib (GO:0002475)3.41220495
61negative regulation of leukocyte mediated immunity (GO:0002704)3.40640275
62negative regulation of interleukin-17 production (GO:0032700)3.37849279
63regulation of mast cell activation (GO:0033003)3.32863195
64regulation of T cell tolerance induction (GO:0002664)3.31223504
65response to muramyl dipeptide (GO:0032495)3.30677337
66positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.30099371
67regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29507420
68regulation of mast cell activation involved in immune response (GO:0033006)3.28799099
69myeloid leukocyte activation (GO:0002274)3.28194816
70natural killer cell mediated cytotoxicity (GO:0042267)3.26643875
71natural killer cell mediated immunity (GO:0002228)3.26643875
72positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.26084148
73regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.24659911
74I-kappaB phosphorylation (GO:0007252)3.24134715
75detection of molecule of bacterial origin (GO:0032490)3.23529207
76regulation of interleukin-8 biosynthetic process (GO:0045414)3.23076585
77interferon-gamma-mediated signaling pathway (GO:0060333)3.22908482
78B cell receptor signaling pathway (GO:0050853)3.18900091
79cellular extravasation (GO:0045123)3.17914800
80regulation of monocyte chemotaxis (GO:0090025)3.17452458
81leukocyte mediated cytotoxicity (GO:0001909)3.14510012
82myeloid leukocyte mediated immunity (GO:0002444)3.13939762
83antigen processing and presentation of endogenous antigen (GO:0019883)3.13926224
84positive regulation of chemokine biosynthetic process (GO:0045080)3.13359084
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13106932
86type I interferon signaling pathway (GO:0060337)3.13003278
87cellular response to type I interferon (GO:0071357)3.13003278
88myeloid dendritic cell differentiation (GO:0043011)3.12755114
89positive regulation of macrophage cytokine production (GO:0060907)3.11303772
90response to type I interferon (GO:0034340)3.09653628
91cellular response to zinc ion (GO:0071294)3.08726314
92monocyte chemotaxis (GO:0002548)3.08394250
93T-helper 1 type immune response (GO:0042088)3.08087805
94positive regulation of leukocyte degranulation (GO:0043302)3.07795007
95positive regulation of gamma-delta T cell activation (GO:0046645)3.06819321
96defense response to protozoan (GO:0042832)3.05292077
97regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.03922237
98negative regulation of erythrocyte differentiation (GO:0045647)3.03042414
99regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.01303269
100myeloid dendritic cell activation (GO:0001773)3.01261685
101positive thymic T cell selection (GO:0045059)3.01147595
102negative regulation of mast cell activation (GO:0033004)3.01136773
103eosinophil chemotaxis (GO:0048245)3.00946741
104G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.00418438
105leukocyte migration involved in inflammatory response (GO:0002523)2.99661651
106positive regulation of B cell differentiation (GO:0045579)2.98570500
107lymphocyte chemotaxis (GO:0048247)2.94446034
108regulation of B cell differentiation (GO:0045577)2.94020892
109phagosome maturation (GO:0090382)2.92952654
110lymphocyte mediated immunity (GO:0002449)2.92495641
111regulation of leukocyte degranulation (GO:0043300)2.91834411
112response to interleukin-15 (GO:0070672)2.91734185
113germinal center formation (GO:0002467)2.91305324
114positive regulation of chemokine production (GO:0032722)2.90661038
115negative thymic T cell selection (GO:0045060)2.89403076
116T cell migration (GO:0072678)2.89247314
117positive regulation of interleukin-12 production (GO:0032735)2.88177402
118regulation of cholesterol storage (GO:0010885)2.87676558
119dendritic cell migration (GO:0036336)2.86964159
120positive regulation of tolerance induction (GO:0002645)2.86870540
121positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86179287
122regulation of regulated secretory pathway (GO:1903305)2.85086624
123dendritic cell differentiation (GO:0097028)2.84408837
124regulation of T-helper 2 cell differentiation (GO:0045628)2.84373843
125negative regulation of cell killing (GO:0031342)2.84227599
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84227599
127positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.82553341
128dendritic cell chemotaxis (GO:0002407)2.82396228
129positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82374073
130response to protozoan (GO:0001562)2.82221159
131negative T cell selection (GO:0043383)2.81825514
132positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.81779881
133cellular response to interferon-beta (GO:0035458)2.81762123
134negative regulation of interleukin-12 production (GO:0032695)2.81488436
135regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81262181
136neutrophil mediated immunity (GO:0002446)2.81134475
137glycosphingolipid catabolic process (GO:0046479)2.81039929
138regulation of interleukin-12 biosynthetic process (GO:0045075)2.80327252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse7.31748416
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.14658795
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.94126172
4* IRF8_27001747_Chip-Seq_BMDM_Mouse5.04777349
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.49556757
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.99141695
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.95431863
8* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80219119
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72622054
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.48520073
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.33631295
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91876222
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.83724616
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78622863
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67170233
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.57741792
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.55424640
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.48583261
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.33692588
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.20367638
21* SPI1_23547873_ChIP-Seq_NB4_Human2.18612566
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15871850
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04147252
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99641805
25PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.89778637
26VDR_24787735_ChIP-Seq_THP-1_Human1.88861116
27PU_27001747_Chip-Seq_BMDM_Mouse1.84844416
28RUNX_20019798_ChIP-Seq_JUKART_Human1.83003891
29* SPI1_23127762_ChIP-Seq_K562_Human1.80943361
30CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.77701831
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76156854
32CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70641461
33VDR_24763502_ChIP-Seq_THP-1_Human1.69476790
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68997525
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68373017
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.65665060
37SCL_19346495_ChIP-Seq_HPC-7_Human1.64997612
38MYB_26560356_Chip-Seq_TH2_Human1.63667263
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60556643
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56507376
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51975860
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46646810
43MYC_22102868_ChIP-Seq_BL_Human1.44249286
44* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44058657
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39059630
46* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37898663
47MAF_26560356_Chip-Seq_TH1_Human1.36023216
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30117971
49PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29192369
50KDM2B_26808549_Chip-Seq_DND41_Human1.25562783
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23124474
52MYB_26560356_Chip-Seq_TH1_Human1.22357713
53* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21279693
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.20842850
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20147912
56SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19907016
57GATA3_27048872_Chip-Seq_THYMUS_Human1.18236225
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16404388
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15496864
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15027498
61VDR_21846776_ChIP-Seq_THP-1_Human1.13211028
62* GATA3_26560356_Chip-Seq_TH2_Human1.12230750
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11613547
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08912934
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05101828
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01463864
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00599861
68IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97439897
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96607201
70SMAD_19615063_ChIP-ChIP_OVARY_Human0.96599055
71* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95385909
72GATA1_22025678_ChIP-Seq_K562_Human0.93975422
73* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92741492
74EGR1_19032775_ChIP-ChIP_M12_Human0.92429383
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92366746
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88618024
77ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88415759
78CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88298855
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87587842
80NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87587842
81UTX_26944678_Chip-Seq_JUKART_Human0.87286854
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87124826
83KDM2B_26808549_Chip-Seq_JURKAT_Human0.83697868
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82811080
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81294071
86* SOX2_20726797_ChIP-Seq_SW620_Human0.79654507
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79051063
88* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79015531
89TCF7_22412390_ChIP-Seq_EML_Mouse0.77418670
90TFEB_21752829_ChIP-Seq_HELA_Human0.77057086
91LXR_22292898_ChIP-Seq_THP-1_Human0.74603426
92SMRT_27268052_Chip-Seq_Bcells_Human0.74192332
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73970668
94GATA2_19941826_ChIP-Seq_K562_Human0.73000812
95* GATA1_19941827_ChIP-Seq_MEL_Mouse0.72530509
96CJUN_26792858_Chip-Seq_BT549_Human0.71432425
97BCL6_27268052_Chip-Seq_Bcells_Human0.71386928
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70977803
99STAT1_20625510_ChIP-Seq_HELA_Human0.70847602
100NCOR1_26117541_ChIP-Seq_K562_Human0.70686781
101SPI1_20517297_ChIP-Seq_HL60_Human0.70467771
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.70027417
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69909626
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68411536
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67947449
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66906201
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.65565139
108GATA1_19941826_ChIP-Seq_K562_Human0.65336171
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.64556148
110MAF_26560356_Chip-Seq_TH2_Human0.61471192
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.60958866
112KDM2B_26808549_Chip-Seq_SUP-B15_Human0.60558342
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59523127
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.59294709
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.58358985
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.55498023
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.55420220
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.54549816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.85270412
2MP0005058_abnormal_lysosome_morphology3.94255849
3MP0006082_CNS_inflammation3.89477488
4MP0002148_abnormal_hypersensitivity_rea3.64052873
5* MP0003436_decreased_susceptibility_to3.44526751
6MP0002419_abnormal_innate_immunity3.44395133
7MP0003303_peritoneal_inflammation3.35015439
8MP0009785_altered_susceptibility_to3.22256886
9* MP0005000_abnormal_immune_tolerance3.18845533
10MP0005025_abnormal_response_to2.91921091
11* MP0002452_abnormal_antigen_presenting2.78210959
12MP0003172_abnormal_lysosome_physiology2.78209247
13MP0003191_abnormal_cellular_cholesterol2.76378366
14MP0005671_abnormal_response_to2.75630685
15MP0005387_immune_system_phenotype2.71399576
16MP0001790_abnormal_immune_system2.71399576
17MP0003724_increased_susceptibility_to2.70581884
18* MP0002723_abnormal_immune_serum2.53038873
19* MP0001800_abnormal_humoral_immune2.47724310
20MP0000685_abnormal_immune_system2.42216107
21MP0004510_myositis2.40548073
22MP0005464_abnormal_platelet_physiology2.30378490
23* MP0001819_abnormal_immune_cell2.28842434
24* MP0002420_abnormal_adaptive_immunity2.25676707
25MP0003075_altered_response_to2.02803908
26* MP0001533_abnormal_skeleton_physiology1.97316511
27MP0002405_respiratory_system_inflammati1.90666818
28MP0003690_abnormal_glial_cell1.90232150
29* MP0001845_abnormal_inflammatory_respons1.87442202
30MP0001853_heart_inflammation1.85985822
31MP0009840_abnormal_foam_cell1.85726691
32MP0000343_altered_response_to1.83614086
33MP0005451_abnormal_body_composition1.78516030
34MP0008469_abnormal_protein_level1.71163054
35MP0002998_abnormal_bone_remodeling1.70666706
36MP0004947_skin_inflammation1.69667261
37MP0003448_altered_tumor_morphology1.68614744
38MP0000604_amyloidosis1.66130563
39MP0009764_decreased_sensitivity_to1.61113898
40MP0005166_decreased_susceptibility_to1.60289433
41MP0000716_abnormal_immune_system1.59534006
42MP0000569_abnormal_digit_pigmentation1.50260220
43MP0010155_abnormal_intestine_physiology1.47017075
44MP0002132_abnormal_respiratory_system1.45202998
45MP0009333_abnormal_splenocyte_physiolog1.43361943
46MP0005167_abnormal_blood-brain_barrier1.41384710
47MP0002398_abnormal_bone_marrow1.39651265
48MP0002006_tumorigenesis1.38016411
49MP0003183_abnormal_peptide_metabolism1.33428970
50* MP0005310_abnormal_salivary_gland1.32131612
51MP0003300_gastrointestinal_ulcer1.29116001
52MP0000689_abnormal_spleen_morphology1.28792982
53MP0000858_altered_metastatic_potential1.27843424
54MP0002277_abnormal_respiratory_mucosa1.26329030
55MP0002429_abnormal_blood_cell1.24915216
56MP0004782_abnormal_surfactant_physiolog1.24627159
57MP0002254_reproductive_system_inflammat1.15481962
58MP0002166_altered_tumor_susceptibility1.14748624
59MP0001851_eye_inflammation1.12928586
60MP0002722_abnormal_immune_system1.11553542
61MP0003828_pulmonary_edema1.09391279
62MP0005257_abnormal_intraocular_pressure1.09136055
63MP0009278_abnormal_bone_marrow1.07963799
64MP0000703_abnormal_thymus_morphology1.06107050
65MP0004381_abnormal_hair_follicle1.04441477
66MP0005164_abnormal_response_to1.01948787
67MP0008004_abnormal_stomach_pH1.00960983
68MP0010307_abnormal_tumor_latency0.99858032
69MP0005174_abnormal_tail_pigmentation0.98055971
70MP0002090_abnormal_vision0.96859533
71MP0002933_joint_inflammation0.95626911
72MP0001545_abnormal_hematopoietic_system0.91312408
73MP0005397_hematopoietic_system_phenotyp0.91312408
74MP0009763_increased_sensitivity_to0.90977897
75MP0000920_abnormal_myelination0.89773674
76MP0003329_amyloid_beta_deposits0.89756502
77MP0000465_gastrointestinal_hemorrhage0.89680218
78MP0003806_abnormal_nucleotide_metabolis0.88630680
79* MP0005390_skeleton_phenotype0.88529424
80MP0000249_abnormal_blood_vessel0.85340972
81MP0003566_abnormal_cell_adhesion0.85269763
82MP0002396_abnormal_hematopoietic_system0.84311494
83MP0004883_abnormal_blood_vessel0.82368504
84MP0005076_abnormal_cell_differentiation0.81836087
85MP0008260_abnormal_autophagy0.81589547
86MP0003186_abnormal_redox_activity0.81107555
87MP0010386_abnormal_urinary_bladder0.78707482
88MP0002138_abnormal_hepatobiliary_system0.77296860
89MP0006054_spinal_hemorrhage0.76713049
90MP0003795_abnormal_bone_structure0.76660654
91MP0002136_abnormal_kidney_physiology0.72235049
92MP0000371_diluted_coat_color0.71749514
93MP0003656_abnormal_erythrocyte_physiolo0.69633271
94MP0002332_abnormal_exercise_endurance0.67409607
95MP0009765_abnormal_xenobiotic_induced0.66831654
96MP0005075_abnormal_melanosome_morpholog0.65823204
97MP0003221_abnormal_cardiomyocyte_apopto0.65754906
98MP0004808_abnormal_hematopoietic_stem0.65561841
99MP0008874_decreased_physiological_sensi0.63281652
100MP0000767_abnormal_smooth_muscle0.62913877
101MP0000015_abnormal_ear_pigmentation0.60974757
102MP0008873_increased_physiological_sensi0.58778501
103MP0001873_stomach_inflammation0.58643368
104MP0003045_fibrosis0.57850118
105MP0002009_preneoplasia0.56526823
106MP0003453_abnormal_keratinocyte_physiol0.56412184
107MP0003091_abnormal_cell_migration0.55761122
108MP0002133_abnormal_respiratory_system0.54554685
109MP0005388_respiratory_system_phenotype0.54554685
110MP0005319_abnormal_enzyme/_coenzyme0.52792316
111MP0000490_abnormal_crypts_of0.52293567
112MP0003866_abnormal_defecation0.51956498
113MP0001663_abnormal_digestive_system0.50411954
114MP0000609_abnormal_liver_physiology0.49827050
115MP0003763_abnormal_thymus_physiology0.49731985
116MP0008438_abnormal_cutaneous_collagen0.49645179
117MP0005165_increased_susceptibility_to0.48132524
118MP0004130_abnormal_muscle_cell0.46999292
119MP0003634_abnormal_glial_cell0.46178040

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.66520118
2Eczematoid dermatitis (HP:0000976)7.07783757
3Recurrent bacterial skin infections (HP:0005406)6.96621454
4Recurrent gram-negative bacterial infections (HP:0005420)6.38680584
5Systemic lupus erythematosus (HP:0002725)5.84193196
6Increased cerebral lipofuscin (HP:0011813)5.32230027
7Abnormality of macrophages (HP:0004311)5.28871455
8Vacuolated lymphocytes (HP:0001922)5.10826405
9Abnormality of glycolipid metabolism (HP:0010969)4.84248489
10Abnormality of liposaccharide metabolism (HP:0010968)4.84248489
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.84248489
12Increased neuronal autofluorescent lipopigment (HP:0002074)4.80983351
13Mediastinal lymphadenopathy (HP:0100721)4.47067507
14Glomerulonephritis (HP:0000099)4.36161477
15Axonal loss (HP:0003447)4.30470927
16Recurrent skin infections (HP:0001581)4.29633628
17Disinhibition (HP:0000734)4.26565563
18Gingivitis (HP:0000230)4.15143047
19Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.94334048
20Chronic obstructive pulmonary disease (HP:0006510)3.91488664
21Obstructive lung disease (HP:0006536)3.91488664
22Autoimmune thrombocytopenia (HP:0001973)3.88124469
23Dysostosis multiplex (HP:0000943)3.83427481
24Gastrointestinal infarctions (HP:0005244)3.81235069
25Myositis (HP:0100614)3.63918768
26Recurrent fungal infections (HP:0002841)3.60744922
27Agnosia (HP:0010524)3.52149743
28Elevated erythrocyte sedimentation rate (HP:0003565)3.47072316
29T lymphocytopenia (HP:0005403)3.45931074
30Orchitis (HP:0100796)3.38843105
31Keratoconjunctivitis (HP:0001096)3.36753071
32Encephalitis (HP:0002383)3.28603875
33Abnormality of T cell number (HP:0011839)3.27266388
34Retrobulbar optic neuritis (HP:0100654)3.22805318
35Optic neuritis (HP:0100653)3.22805318
36Stomatitis (HP:0010280)3.22025395
37Basal ganglia calcification (HP:0002135)3.19528727
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.10880631
39Thick nail (HP:0001805)3.06354070
40Cellulitis (HP:0100658)3.03580465
41Urinary glycosaminoglycan excretion (HP:0003541)3.02542087
42Mucopolysacchariduria (HP:0008155)3.02542087
43Pustule (HP:0200039)2.98257070
44Prostate neoplasm (HP:0100787)2.95831345
45Chronic mucocutaneous candidiasis (HP:0002728)2.91019666
46Recurrent cutaneous fungal infections (HP:0011370)2.91019666
47Recurrent viral infections (HP:0004429)2.88382265
48Periodontitis (HP:0000704)2.87798431
49Chest pain (HP:0100749)2.85761475
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.84813957
51Abnormality of polysaccharide metabolism (HP:0011012)2.84813957
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.84813957
53Vasculitis (HP:0002633)2.83595557
54Upper motor neuron abnormality (HP:0002127)2.78947659
55Interstitial pulmonary disease (HP:0006530)2.77822398
56Myocardial infarction (HP:0001658)2.76450404
57Recurrent pneumonia (HP:0006532)2.73602492
58Nephritis (HP:0000123)2.72803880
59Hepatosplenomegaly (HP:0001433)2.70242232
60Loss of speech (HP:0002371)2.69149115
61Urticaria (HP:0001025)2.68214468
62Hematochezia (HP:0002573)2.64734429
63Complement deficiency (HP:0004431)2.64125913
64Pulmonary embolism (HP:0002204)2.59434916
65Prolonged bleeding time (HP:0003010)2.58078948
66Abnormality of complement system (HP:0005339)2.57635909
67Osteomyelitis (HP:0002754)2.55751702
68Meningitis (HP:0001287)2.54961414
69Episodic fever (HP:0001954)2.54237342
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.54181537
71Increased IgE level (HP:0003212)2.52907248
72Anorexia (HP:0002039)2.47622927
73Peritonitis (HP:0002586)2.46826743
74Gangrene (HP:0100758)2.45488952
75Epistaxis (HP:0000421)2.43955184
76Pathologic fracture (HP:0002756)2.42721268
77Abnormality of T cells (HP:0002843)2.42691692
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41789376
79Pulmonary infiltrates (HP:0002113)2.37814980
80Increased IgM level (HP:0003496)2.34043571
81Recurrent lower respiratory tract infections (HP:0002783)2.28093486
82Inappropriate behavior (HP:0000719)2.25354131
83Colitis (HP:0002583)2.23777470
84Abnormality of the pleura (HP:0002103)2.22653005
85Retinal atrophy (HP:0001105)2.22136707
86Leukocytosis (HP:0001974)2.20947176
87Tetraparesis (HP:0002273)2.19149702
88Osteolytic defects of the hand bones (HP:0009699)2.18957636
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.18957636
90Bone pain (HP:0002653)2.17501844
91Polyneuropathy (HP:0001271)2.16431647
92Increased serum ferritin (HP:0003281)2.14195084
93Vertigo (HP:0002321)2.13656147
94Mutism (HP:0002300)2.13264466
95Joint hemorrhage (HP:0005261)2.13068187
96Arterial thrombosis (HP:0004420)2.12833698
97Progressive visual loss (HP:0000529)2.10993893
98Spontaneous hematomas (HP:0007420)2.10693452
99Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10096711
100Petechiae (HP:0000967)2.09683495
101Glomerulopathy (HP:0100820)2.08008742
102Peripheral demyelination (HP:0011096)2.07767620
103Premature loss of primary teeth (HP:0006323)2.07736791
104Hemoptysis (HP:0002105)2.06135822
105Amaurosis fugax (HP:0100576)2.05568702
106Diminished motivation (HP:0000745)2.05317641
107Abnormality of the endocardium (HP:0004306)2.05226060
108Apathy (HP:0000741)2.05221270
109Hypergammaglobulinemia (HP:0010702)2.02728862
110Abnormality of the peritoneum (HP:0002585)2.02206620
111Granulocytopenia (HP:0001913)2.02181436
112Inflammation of the large intestine (HP:0002037)2.00390399
113Panhypogammaglobulinemia (HP:0003139)1.95903133
114Chronic otitis media (HP:0000389)1.94853868
115Abnormality of iron homeostasis (HP:0011031)1.90371866
116Malnutrition (HP:0004395)1.89525397
117Poor head control (HP:0002421)1.88661564
118Cheilitis (HP:0100825)1.88167833
119Gingival bleeding (HP:0000225)1.87841318
120Acne (HP:0001061)1.87353090
121Viral hepatitis (HP:0006562)1.85879541
122Sepsis (HP:0100806)1.84960503
123Purpura (HP:0000979)1.84352918
124Slow saccadic eye movements (HP:0000514)1.83768832
125J-shaped sella turcica (HP:0002680)1.82961438
126Skin ulcer (HP:0200042)1.82373193
127Recurrent bronchitis (HP:0002837)1.81447330
128Gastrointestinal inflammation (HP:0004386)1.81050391
129Personality changes (HP:0000751)1.79880874
130Amyloidosis (HP:0011034)1.79378905
131Keratoconjunctivitis sicca (HP:0001097)1.77848342
132Eosinophilia (HP:0001880)1.75542423
133Abnormality of the lumbar spine (HP:0100712)1.75233751
134Conjunctival telangiectasia (HP:0000524)1.74325366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.77944144
2BLK3.94239839
3MAP3K143.78197340
4TBK13.32588861
5TYK23.31706784
6IRAK43.23503353
7TGFBR23.17885124
8PBK2.85673819
9IRAK32.67745657
10KIT2.55068421
11MAP4K12.51034807
12PRPF4B2.45822929
13IKBKE2.25772358
14IKBKB2.19482642
15JAK12.09673762
16CSF1R2.09398026
17GRK71.96375460
18TXK1.88189259
19JAK31.87847715
20ERN11.72899357
21NEK91.70887485
22MAP3K131.66671920
23CSK1.61045069
24SYK1.57544276
25ZAP701.50125946
26HCK1.48496236
27TNK21.44480412
28TAOK11.43502183
29LYN1.40873858
30PIM21.37710230
31MAP3K11.30188829
32FGR1.26547192
33NME21.26319389
34JAK21.21172367
35MATK1.20473554
36LCK1.19692062
37KSR21.17255232
38STK101.14510485
39TAOK31.13940661
40CHUK1.11933757
41BTK1.11028337
42FES1.09249409
43MST41.04078400
44ABL21.01566783
45BMPR21.00433685
46MAP3K20.99677575
47TEC0.97285371
48MST1R0.97182363
49MARK30.96801853
50ITK0.93998154
51EPHB10.93778651
52ARAF0.92338163
53TAOK20.89148743
54RIPK10.88085408
55RPS6KA40.87780461
56PIM10.87639065
57MOS0.86879401
58BMX0.86759399
59ACVR1B0.86621189
60CAMK1D0.83947083
61CLK10.82773445
62PDK20.79778911
63PRKCD0.79510829
64YES10.79472475
65TRPM70.77391388
66MARK20.77161293
67FGFR30.76775228
68ADRBK20.75742514
69MAP2K30.75404420
70EGFR0.73605238
71MAP3K60.73417979
72ABL10.70285606
73FGFR40.69692836
74CDC42BPA0.69395128
75STK40.65494018
76MAPK70.63734583
77SGK30.62776169
78SCYL20.61507339
79ERBB30.59149531
80EIF2AK20.58454693
81TESK20.58011125
82IRAK20.55184224
83SIK20.54894397
84MAP3K100.54197391
85PAK40.53260883
86PDK10.52906752
87KSR10.51195065
88CAMKK20.50020916
89SGK20.49500390
90CDK190.48904745
91DYRK1B0.44752202
92PDPK10.44716018
93PRKCQ0.44673244
94FYN0.44374370
95PTK2B0.44364544
96IRAK10.43553566
97NLK0.43050593
98RAF10.42643171
99MAP2K40.42530151
100LRRK20.42346910
101IGF1R0.41894043
102RPS6KC10.40898537
103RPS6KL10.40898537
104MAPKAPK20.40629018
105DAPK20.40540799
106STK110.40400744
107PRKD20.40238519
108TRIB30.39071516
109MAP2K60.37379188
110HIPK20.37337120
111TTN0.37059849
112MAPK150.36745300
113MAP3K30.36278426
114CDK60.35987247
115CAMKK10.35437414
116PTK60.34508182
117RET0.34172134
118MAP3K70.33321486
119PIK3CG0.31832575
120CAMK1G0.31461871
121PDGFRB0.31411020
122MAPK120.30082950
123SIK30.29630688
124MAP3K50.29111762
125EPHA30.28692940
126MAP3K110.28439543
127INSR0.27132680
128PKN20.26865359
129RPS6KA60.25587036
130GRK60.24626914
131STK30.23845401
132PRKCH0.21520431

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.99904137
2Leishmaniasis_Homo sapiens_hsa051403.36681586
3* Lysosome_Homo sapiens_hsa041422.95007150
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.76077644
5Osteoclast differentiation_Homo sapiens_hsa043802.73671430
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.63167096
7Other glycan degradation_Homo sapiens_hsa005112.52735788
8Graft-versus-host disease_Homo sapiens_hsa053322.49918749
9Pertussis_Homo sapiens_hsa051332.44467536
10Legionellosis_Homo sapiens_hsa051342.35719781
11* Tuberculosis_Homo sapiens_hsa051522.34134835
12Rheumatoid arthritis_Homo sapiens_hsa053232.30882332
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.23321332
14Malaria_Homo sapiens_hsa051442.07905802
15* Phagosome_Homo sapiens_hsa041452.06717893
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97084325
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95151387
18Allograft rejection_Homo sapiens_hsa053301.86310459
19B cell receptor signaling pathway_Homo sapiens_hsa046621.86123677
20Measles_Homo sapiens_hsa051621.84197686
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79870088
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.74642716
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74200278
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73010682
25Salmonella infection_Homo sapiens_hsa051321.70774910
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.66233282
27Influenza A_Homo sapiens_hsa051641.57212077
28Asthma_Homo sapiens_hsa053101.55389343
29Toxoplasmosis_Homo sapiens_hsa051451.52833402
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46188135
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45309632
32TNF signaling pathway_Homo sapiens_hsa046681.44187008
33Chemokine signaling pathway_Homo sapiens_hsa040621.42454966
34Hematopoietic cell lineage_Homo sapiens_hsa046401.41955322
35* Antigen processing and presentation_Homo sapiens_hsa046121.40322595
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32980236
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32861612
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25706221
39Type I diabetes mellitus_Homo sapiens_hsa049401.24390821
40* Apoptosis_Homo sapiens_hsa042101.22309477
41African trypanosomiasis_Homo sapiens_hsa051431.21487533
42Complement and coagulation cascades_Homo sapiens_hsa046101.18521078
43Shigellosis_Homo sapiens_hsa051311.17322544
44Herpes simplex infection_Homo sapiens_hsa051681.16750765
45Collecting duct acid secretion_Homo sapiens_hsa049661.10419980
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06398705
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.06091840
48Prion diseases_Homo sapiens_hsa050201.04324606
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.97704092
50Non-small cell lung cancer_Homo sapiens_hsa052230.94917233
51Viral myocarditis_Homo sapiens_hsa054160.94618489
52Hepatitis B_Homo sapiens_hsa051610.94527707
53Primary immunodeficiency_Homo sapiens_hsa053400.91949891
54Autoimmune thyroid disease_Homo sapiens_hsa053200.90380079
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88731462
56Hepatitis C_Homo sapiens_hsa051600.83086098
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81659808
58Amoebiasis_Homo sapiens_hsa051460.81496259
59T cell receptor signaling pathway_Homo sapiens_hsa046600.75848432
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75181829
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74259439
62Platelet activation_Homo sapiens_hsa046110.70519743
63Pancreatic cancer_Homo sapiens_hsa052120.64033536
64Sphingolipid metabolism_Homo sapiens_hsa006000.57781130
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.55728046
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54882823
67Chronic myeloid leukemia_Homo sapiens_hsa052200.54425838
68Mineral absorption_Homo sapiens_hsa049780.53832191
69Acute myeloid leukemia_Homo sapiens_hsa052210.53774505
70GnRH signaling pathway_Homo sapiens_hsa049120.53323919
71Endocytosis_Homo sapiens_hsa041440.52754713
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51186103
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.50399367
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50070315
75Caffeine metabolism_Homo sapiens_hsa002320.48337221
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44687807
77Vibrio cholerae infection_Homo sapiens_hsa051100.44417606
78Endometrial cancer_Homo sapiens_hsa052130.43999494
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42133928
80Renin-angiotensin system_Homo sapiens_hsa046140.40895882
81Insulin resistance_Homo sapiens_hsa049310.40300336
82Prolactin signaling pathway_Homo sapiens_hsa049170.39941391
83Epstein-Barr virus infection_Homo sapiens_hsa051690.39750207
84mTOR signaling pathway_Homo sapiens_hsa041500.39523479
85HTLV-I infection_Homo sapiens_hsa051660.39231401
86Choline metabolism in cancer_Homo sapiens_hsa052310.38800558
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37972827
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37646600
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35923783
90HIF-1 signaling pathway_Homo sapiens_hsa040660.35502154
91Inositol phosphate metabolism_Homo sapiens_hsa005620.34664138
92Steroid biosynthesis_Homo sapiens_hsa001000.31388328
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30533473
94MAPK signaling pathway_Homo sapiens_hsa040100.30185128
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.30125402
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27839744
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27820492
98Type II diabetes mellitus_Homo sapiens_hsa049300.26252367
99Estrogen signaling pathway_Homo sapiens_hsa049150.25857004
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25506418
101Viral carcinogenesis_Homo sapiens_hsa052030.25299849
102ErbB signaling pathway_Homo sapiens_hsa040120.25280016
103Proteoglycans in cancer_Homo sapiens_hsa052050.24891520
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23556734
105VEGF signaling pathway_Homo sapiens_hsa043700.22702406
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22640195
107Ether lipid metabolism_Homo sapiens_hsa005650.21507826
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21505933
109Notch signaling pathway_Homo sapiens_hsa043300.18841241
110Renal cell carcinoma_Homo sapiens_hsa052110.18316839
111Dorso-ventral axis formation_Homo sapiens_hsa043200.17100542
112Adherens junction_Homo sapiens_hsa045200.13882028
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12286253
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.11566719
115FoxO signaling pathway_Homo sapiens_hsa040680.11467793

Most similar genes based on co-expression Upload to Enrichr

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