CTSD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.39973803
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.39973803
3positive regulation by organism of defense response of other organism involved in symbiotic interact7.39973803
4modulation by symbiont of host immune response (GO:0052553)7.39973803
5positive regulation by symbiont of host defense response (GO:0052509)7.39973803
6modulation by symbiont of host defense response (GO:0052031)7.39973803
7regulation of interferon-beta biosynthetic process (GO:0045357)6.24526190
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.01853637
9macrophage activation involved in immune response (GO:0002281)5.79965328
10microglial cell activation (GO:0001774)5.43016959
11oligosaccharide catabolic process (GO:0009313)4.91022863
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.85744443
13response to host immune response (GO:0052572)4.74546533
14response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.74546533
15neutrophil activation involved in immune response (GO:0002283)4.61462542
16amino sugar catabolic process (GO:0046348)4.56334657
17positive regulation of interferon-alpha production (GO:0032727)4.52821614
18response to host (GO:0075136)4.42288466
19response to host defenses (GO:0052200)4.42288466
20response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.42288466
21ceramide catabolic process (GO:0046514)4.27791851
22regulation of interferon-alpha production (GO:0032647)4.26850167
23macrophage activation (GO:0042116)4.09403625
24barbed-end actin filament capping (GO:0051016)4.08672590
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.84597717
26apoptotic cell clearance (GO:0043277)3.78355780
27response to peptidoglycan (GO:0032494)3.74162470
28keratan sulfate catabolic process (GO:0042340)3.72103242
29mannose metabolic process (GO:0006013)3.65173422
30regulation of B cell receptor signaling pathway (GO:0050855)3.61597135
31immunoglobulin mediated immune response (GO:0016064)3.60488518
32membrane lipid catabolic process (GO:0046466)3.55974482
33respiratory burst (GO:0045730)3.52961144
34myeloid cell activation involved in immune response (GO:0002275)3.52608425
35sphingolipid catabolic process (GO:0030149)3.51617241
36N-acetylneuraminate metabolic process (GO:0006054)3.44874532
37protein localization to endosome (GO:0036010)3.44661968
38I-kappaB phosphorylation (GO:0007252)3.43598626
39positive regulation of antigen processing and presentation (GO:0002579)3.41317152
40regulation of cholesterol storage (GO:0010885)3.41110792
41regulation of mononuclear cell migration (GO:0071675)3.35574996
42hyaluronan catabolic process (GO:0030214)3.32440708
43pinocytosis (GO:0006907)3.30934401
44low-density lipoprotein particle clearance (GO:0034383)3.26680558
45cell adhesion mediated by integrin (GO:0033627)3.19388721
46peptide catabolic process (GO:0043171)3.17744612
47regulation of superoxide anion generation (GO:0032928)3.15476151
48negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.13629467
49positive regulation of interferon-beta production (GO:0032728)3.11217117
50cellular response to thyroid hormone stimulus (GO:0097067)3.10486626
51regulation of interleukin-8 biosynthetic process (GO:0045414)3.08814959
52negative regulation of nitric oxide biosynthetic process (GO:0045019)3.05718679
53positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.05288511
54positive regulation of cholesterol efflux (GO:0010875)3.05189420
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04829850
56epithelial cell differentiation involved in prostate gland development (GO:0060742)3.03704387
57glycosphingolipid catabolic process (GO:0046479)3.03399608
58granulocyte activation (GO:0036230)3.03252165
59positive regulation of monocyte chemotaxis (GO:0090026)3.01679810
60positive regulation of chemokine secretion (GO:0090197)2.99199950
61negative regulation of granulocyte differentiation (GO:0030853)2.97639607
62adhesion of symbiont to host (GO:0044406)2.96240772
63detection of molecule of bacterial origin (GO:0032490)2.95310068
64positive regulation of chemokine biosynthetic process (GO:0045080)2.93615526
65positive regulation of mast cell activation (GO:0033005)2.91690436
66amyloid precursor protein catabolic process (GO:0042987)2.90861835
67regulation of mast cell degranulation (GO:0043304)2.90423849
68negative regulation of erythrocyte differentiation (GO:0045647)2.90377396
69regulation of myeloid leukocyte mediated immunity (GO:0002886)2.90269232
70myeloid dendritic cell differentiation (GO:0043011)2.89213235
71neutrophil activation (GO:0042119)2.89162347
72regulation of antigen processing and presentation (GO:0002577)2.88306283
73positive regulation of leukocyte degranulation (GO:0043302)2.87761209
74positive regulation of macrophage cytokine production (GO:0060907)2.86610002
75NIK/NF-kappaB signaling (GO:0038061)2.86604263
76negative regulation of interleukin-17 production (GO:0032700)2.86243524
77positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.85090299
78positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.83646271
79T-helper 1 type immune response (GO:0042088)2.82715817
80positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.81767567
81detection of other organism (GO:0098543)2.77741478
82positive regulation of cellular amide metabolic process (GO:0034250)2.76539644
83regulation of leukocyte degranulation (GO:0043300)2.74341497
84regulation of mast cell activation involved in immune response (GO:0033006)2.74193581
85negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73138433
86glycolipid catabolic process (GO:0019377)2.71424523
87regulation of macrophage chemotaxis (GO:0010758)2.70142142
88regulation of macrophage cytokine production (GO:0010935)2.70051299
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.69151013
90cellular extravasation (GO:0045123)2.68969787
91negative regulation of interleukin-6 production (GO:0032715)2.68488384
92response to laminar fluid shear stress (GO:0034616)2.68349412
93lytic vacuole organization (GO:0080171)2.68335610
94lysosome organization (GO:0007040)2.68335610
95fat-soluble vitamin biosynthetic process (GO:0042362)2.68312364
96detection of external biotic stimulus (GO:0098581)2.67791056
97regulation of chemokine-mediated signaling pathway (GO:0070099)2.66878867
98regulation of mast cell activation (GO:0033003)2.66705530
99response to muramyl dipeptide (GO:0032495)2.66345930
100regulation of podosome assembly (GO:0071801)2.66150218
101production of molecular mediator involved in inflammatory response (GO:0002532)2.65947409
102negative regulation of mast cell activation (GO:0033004)2.65837951
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.62771674
104response to thyroid hormone (GO:0097066)2.62089641
105hydrogen peroxide biosynthetic process (GO:0050665)2.60477655
106antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60387463
107antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60387463
108detection of bacterium (GO:0016045)2.60379407
109positive regulation of chemokine production (GO:0032722)2.59787827
110G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.58968932
111positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.58684016
112regulation of monocyte chemotaxis (GO:0090025)2.57903897
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.57308607
114negative regulation of cell killing (GO:0031342)2.57308607
115phagosome maturation (GO:0090382)2.57206458
116positive regulation of gamma-delta T cell activation (GO:0046645)2.57086870
117regulation of vitamin D biosynthetic process (GO:0060556)2.55885752
118myeloid leukocyte activation (GO:0002274)2.53859718
119response to acidic pH (GO:0010447)2.53373689
120negative regulation of lipid storage (GO:0010888)2.52887553
121positive regulation of extracellular matrix organization (GO:1903055)2.51994402
122positive regulation of B cell differentiation (GO:0045579)2.49896095
123positive regulation of bone remodeling (GO:0046852)2.49755206
124positive regulation of bone resorption (GO:0045780)2.49755206
125decidualization (GO:0046697)2.49315867
126myeloid dendritic cell activation (GO:0001773)2.49271891
127cellular response to arsenic-containing substance (GO:0071243)2.48896726
128macrophage differentiation (GO:0030225)2.48644014
129positive regulation of cholesterol transport (GO:0032376)2.48420186
130positive regulation of sterol transport (GO:0032373)2.48420186
131negative regulation of interleukin-12 production (GO:0032695)2.47903843
132phospholipid efflux (GO:0033700)2.47847558
133regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.47797219
134regulation of regulated secretory pathway (GO:1903305)2.47737907
135adenosine receptor signaling pathway (GO:0001973)2.47644246
136negative regulation of cytokine production involved in immune response (GO:0002719)2.46874648
137regulation of membrane protein ectodomain proteolysis (GO:0051043)2.46651461
138angiotensin maturation (GO:0002003)2.46260373
139response to magnesium ion (GO:0032026)2.45667634
140positive regulation of lipoprotein lipase activity (GO:0051006)2.44983757
141positive regulation of triglyceride lipase activity (GO:0061365)2.44983757
142positive regulation of mast cell degranulation (GO:0043306)2.44734638
143positive regulation of mast cell activation involved in immune response (GO:0033008)2.44734638
144regulation of early endosome to late endosome transport (GO:2000641)2.44326153
145monocyte chemotaxis (GO:0002548)2.44140205
146response to lipoprotein particle (GO:0055094)2.44004874
147adhesion of symbiont to host cell (GO:0044650)2.43396216
148virion attachment to host cell (GO:0019062)2.43396216
149substrate-dependent cell migration (GO:0006929)2.43051277
150germinal center formation (GO:0002467)2.42883981
151B cell mediated immunity (GO:0019724)2.40690880
152cellular response to interferon-alpha (GO:0035457)2.39835015
153neutrophil chemotaxis (GO:0030593)2.38094908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse5.27787613
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.84074172
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.45525549
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.96293978
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.81253117
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.45097585
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.44145093
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.05040004
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97440947
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.78873960
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.77394084
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.68566386
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32786199
14BRD4_27068464_Chip-Seq_AML-cells_Mouse2.25938087
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.21523747
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19122389
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13817108
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06956742
19* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03698095
20SPI1_23127762_ChIP-Seq_K562_Human2.03337829
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00611916
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.95987959
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93337911
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87493244
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87060624
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82906177
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79429822
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72970801
29VDR_24763502_ChIP-Seq_THP-1_Human1.71919885
30SPI1_23547873_ChIP-Seq_NB4_Human1.69830803
31CLOCK_20551151_ChIP-Seq_293T_Human1.68733752
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.68009077
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.67714305
34VDR_21846776_ChIP-Seq_THP-1_Human1.64202493
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63708204
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.61172450
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.57651938
38* VDR_24787735_ChIP-Seq_THP-1_Human1.56453116
39NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.54944112
40ZNF263_19887448_ChIP-Seq_K562_Human1.53479772
41PU_27001747_Chip-Seq_BMDM_Mouse1.53138519
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53104478
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52092172
44RUNX_20019798_ChIP-Seq_JUKART_Human1.49235096
45SCL_19346495_ChIP-Seq_HPC-7_Human1.48592306
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45887331
47* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45564731
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45463018
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45023156
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44380342
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42701061
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40419827
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40042013
54MAF_26560356_Chip-Seq_TH1_Human1.38965957
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35612994
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35609964
57* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35136903
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33582219
59* LXR_22292898_ChIP-Seq_THP-1_Human1.33419759
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32391039
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30925486
62KDM2B_26808549_Chip-Seq_K562_Human1.30552096
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29239479
64* GATA1_19941827_ChIP-Seq_MEL_Mouse1.27413925
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26731802
66MYC_22102868_ChIP-Seq_BL_Human1.26600041
67TCF7_22412390_ChIP-Seq_EML_Mouse1.26175551
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24355904
69MYB_26560356_Chip-Seq_TH2_Human1.24293067
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23008208
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22953787
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22285482
73GATA1_22025678_ChIP-Seq_K562_Human1.21959954
74TFEB_21752829_ChIP-Seq_HELA_Human1.20581287
75* ESR2_21235772_ChIP-Seq_MCF-7_Human1.18388044
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.17795220
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17480714
78GATA1_19941826_ChIP-Seq_K562_Human1.16871783
79BCOR_27268052_Chip-Seq_Bcells_Human1.16193598
80* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15920130
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14991467
82LXR_22158963_ChIP-Seq_LIVER_Mouse1.13805345
83* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13527219
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13499770
85PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13057973
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12736679
87* KDM2B_26808549_Chip-Seq_DND41_Human1.12632195
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12173640
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11489142
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10483805
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10076271
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09766323
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09691534
94BCL6_27268052_Chip-Seq_Bcells_Human1.09660124
95* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08091249
96* ESR1_21235772_ChIP-Seq_MCF-7_Human1.07694027
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07671930
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06523863
99GATA2_19941826_ChIP-Seq_K562_Human1.05862898
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05404581
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05193134
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.04899885
103P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04805523
104* SOX2_20726797_ChIP-Seq_SW620_Human1.04354186
105P68_20966046_ChIP-Seq_HELA_Human1.04334730
106* UTX_26944678_Chip-Seq_JUKART_Human1.03937118
107* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03260315
108RXR_22158963_ChIP-Seq_LIVER_Mouse1.03071317
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02336504
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02334443
111GATA3_27048872_Chip-Seq_THYMUS_Human1.02106934
112* CJUN_26792858_Chip-Seq_BT549_Human1.01869750
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.00820651
114* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00698122
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00294389
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00176749
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.99095089
118RACK7_27058665_Chip-Seq_MCF-7_Human0.98024915
119HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95082287
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94589158
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94589158
122MYB_26560356_Chip-Seq_TH1_Human0.94467992
123* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93531792
124* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93191655
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92948606
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92186962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.50000655
2MP0006082_CNS_inflammation3.54395537
3MP0003191_abnormal_cellular_cholesterol3.38651795
4MP0003303_peritoneal_inflammation3.29362950
5MP0003436_decreased_susceptibility_to3.04469964
6MP0009840_abnormal_foam_cell3.01806695
7MP0008438_abnormal_cutaneous_collagen2.75960213
8MP0002139_abnormal_hepatobiliary_system2.64773977
9* MP0003172_abnormal_lysosome_physiology2.63917872
10MP0002419_abnormal_innate_immunity2.63688472
11* MP0001835_abnormal_antigen_presentation2.46295139
12MP0005451_abnormal_body_composition2.31881307
13MP0003300_gastrointestinal_ulcer2.25874013
14MP0003690_abnormal_glial_cell2.13742282
15MP0005000_abnormal_immune_tolerance2.13631063
16MP0001533_abnormal_skeleton_physiology2.12375012
17MP0005464_abnormal_platelet_physiology2.08208442
18MP0003705_abnormal_hypodermis_morpholog2.07573452
19MP0003566_abnormal_cell_adhesion2.05287469
20MP0002148_abnormal_hypersensitivity_rea2.03858063
21MP0000604_amyloidosis1.98950966
22MP0000343_altered_response_to1.97334604
23MP0009785_altered_susceptibility_to1.95800080
24MP0005257_abnormal_intraocular_pressure1.95770561
25MP0003329_amyloid_beta_deposits1.90781100
26MP0005025_abnormal_response_to1.87572379
27MP0003075_altered_response_to1.87391194
28MP0004510_myositis1.87335252
29MP0002452_abnormal_antigen_presenting1.86592160
30MP0003724_increased_susceptibility_to1.83217063
31MP0002877_abnormal_melanocyte_morpholog1.70137001
32MP0008260_abnormal_autophagy1.68532511
33MP0003448_altered_tumor_morphology1.66697507
34MP0001958_emphysema1.65159138
35MP0005387_immune_system_phenotype1.64652814
36MP0001790_abnormal_immune_system1.64652814
37MP0002998_abnormal_bone_remodeling1.63146614
38MP0003806_abnormal_nucleotide_metabolis1.61768450
39MP0004947_skin_inflammation1.60405983
40MP0002723_abnormal_immune_serum1.59871499
41MP0005167_abnormal_blood-brain_barrier1.52917778
42MP0005671_abnormal_response_to1.50920744
43MP0001819_abnormal_immune_cell1.46959256
44MP0001800_abnormal_humoral_immune1.44902510
45MP0002420_abnormal_adaptive_immunity1.44647502
46MP0009278_abnormal_bone_marrow1.43309908
47MP0001845_abnormal_inflammatory_respons1.42098392
48MP0005365_abnormal_bile_salt1.41614859
49MP0005166_decreased_susceptibility_to1.40806005
50MP0008469_abnormal_protein_level1.39009969
51MP0002405_respiratory_system_inflammati1.38592927
52MP0000858_altered_metastatic_potential1.38234262
53MP0010307_abnormal_tumor_latency1.36717187
54MP0004130_abnormal_muscle_cell1.35622709
55MP0003183_abnormal_peptide_metabolism1.34914094
56MP0000685_abnormal_immune_system1.34482493
57MP0001849_ear_inflammation1.25628438
58MP0005310_abnormal_salivary_gland1.25110574
59MP0000569_abnormal_digit_pigmentation1.24645748
60MP0003279_aneurysm1.23901367
61MP0001851_eye_inflammation1.20302343
62MP0004185_abnormal_adipocyte_glucose1.16333718
63MP0002254_reproductive_system_inflammat1.13767466
64MP0001853_heart_inflammation1.12923893
65MP0002933_joint_inflammation1.12434206
66MP0010234_abnormal_vibrissa_follicle1.12173946
67MP0005023_abnormal_wound_healing1.11704685
68MP0003828_pulmonary_edema1.11554056
69MP0005275_abnormal_skin_tensile1.11520862
70MP0009764_decreased_sensitivity_to1.10742864
71MP0000465_gastrointestinal_hemorrhage1.09629737
72MP0005390_skeleton_phenotype1.09497379
73MP0003091_abnormal_cell_migration1.07022054
74MP0005164_abnormal_response_to1.04712818
75MP0004858_abnormal_nervous_system0.98868482
76MP0009333_abnormal_splenocyte_physiolog0.98593127
77MP0005670_abnormal_white_adipose0.97765102
78MP0000249_abnormal_blood_vessel0.95964968
79MP0003045_fibrosis0.94375128
80* MP0000716_abnormal_immune_system0.94024494
81MP0010155_abnormal_intestine_physiology0.92193327
82* MP0003634_abnormal_glial_cell0.91437192
83MP0000767_abnormal_smooth_muscle0.91180299
84MP0004019_abnormal_vitamin_homeostasis0.90111223
85MP0003656_abnormal_erythrocyte_physiolo0.89724995
86* MP0000689_abnormal_spleen_morphology0.89520844
87MP0004883_abnormal_blood_vessel0.88772424
88MP0002166_altered_tumor_susceptibility0.88214102
89MP0005397_hematopoietic_system_phenotyp0.87382094
90MP0001545_abnormal_hematopoietic_system0.87382094
91MP0003795_abnormal_bone_structure0.85771861
92MP0001542_abnormal_bone_strength0.84528818
93MP0005165_increased_susceptibility_to0.83534662
94MP0003453_abnormal_keratinocyte_physiol0.82896232
95MP0005076_abnormal_cell_differentiation0.82604283
96MP0000371_diluted_coat_color0.81849807
97MP0005666_abnormal_adipose_tissue0.80756165
98MP0004782_abnormal_surfactant_physiolog0.79885437
99MP0003879_abnormal_hair_cell0.78144634
100MP0002006_tumorigenesis0.77589607
101MP0002896_abnormal_bone_mineralization0.77127323
102* MP0002429_abnormal_blood_cell0.76288455
103MP0002136_abnormal_kidney_physiology0.75408834
104MP0010352_gastrointestinal_tract_polyps0.74287757
105* MP0002398_abnormal_bone_marrow0.73108033
106MP0002295_abnormal_pulmonary_circulatio0.72499208
107MP0009763_increased_sensitivity_to0.72421394
108MP0004264_abnormal_extraembryonic_tissu0.71724631
109* MP0002722_abnormal_immune_system0.71484419
110MP0000609_abnormal_liver_physiology0.71194433
111* MP0002090_abnormal_vision0.70865220
112MP0008004_abnormal_stomach_pH0.70519602
113MP0000920_abnormal_myelination0.70343941
114MP0001915_intracranial_hemorrhage0.70274832
115MP0005197_abnormal_uvea_morphology0.69954797
116MP0006054_spinal_hemorrhage0.69398375
117MP0005319_abnormal_enzyme/_coenzyme0.67790629
118MP0000747_muscle_weakness0.65922574
119MP0005360_urolithiasis0.65320336
120MP0001663_abnormal_digestive_system0.64931419
121MP0005584_abnormal_enzyme/coenzyme_acti0.64818097
122MP0002796_impaired_skin_barrier0.61927855
123MP0001216_abnormal_epidermal_layer0.61605556
124MP0008874_decreased_physiological_sensi0.61577001

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.98793406
2Vacuolated lymphocytes (HP:0001922)5.74952717
3Abnormality of glycolipid metabolism (HP:0010969)5.63106292
4Abnormality of liposaccharide metabolism (HP:0010968)5.63106292
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.63106292
6Dysostosis multiplex (HP:0000943)5.52960486
7Recurrent abscess formation (HP:0002722)5.27994426
8* Increased cerebral lipofuscin (HP:0011813)5.23480891
9Eczematoid dermatitis (HP:0000976)4.81662855
10Mucopolysacchariduria (HP:0008155)4.54515094
11Urinary glycosaminoglycan excretion (HP:0003541)4.54515094
12Recurrent bacterial skin infections (HP:0005406)4.49673933
13Glomerulonephritis (HP:0000099)4.40607330
14Axonal loss (HP:0003447)4.39641326
15Recurrent gram-negative bacterial infections (HP:0005420)4.30756960
16Abnormality of polysaccharide metabolism (HP:0011012)4.27661740
17Abnormality of glycosaminoglycan metabolism (HP:0004371)4.27661740
18Abnormality of mucopolysaccharide metabolism (HP:0011020)4.27661740
19Abnormality of macrophages (HP:0004311)4.23223209
20Disinhibition (HP:0000734)4.07176223
21* Increased neuronal autofluorescent lipopigment (HP:0002074)3.89154120
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.58856438
23Nuclear cataract (HP:0100018)3.54497884
24Cerebral aneurysm (HP:0004944)3.50812759
25Complement deficiency (HP:0004431)3.30935596
26Loss of speech (HP:0002371)3.25739728
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.18909598
28Asymmetric septal hypertrophy (HP:0001670)3.14376045
29Cerebral inclusion bodies (HP:0100314)3.06245325
30Hematochezia (HP:0002573)2.95313133
31Purpura (HP:0000979)2.94878025
32Nephritis (HP:0000123)2.90344267
33Abnormality of complement system (HP:0005339)2.86713974
34Arterial tortuosity (HP:0005116)2.83881332
35Interstitial pulmonary disease (HP:0006530)2.79680835
36Gingivitis (HP:0000230)2.79188111
37Agnosia (HP:0010524)2.78806461
38Myocardial infarction (HP:0001658)2.78015306
39Upper motor neuron abnormality (HP:0002127)2.69430646
40Vascular tortuosity (HP:0004948)2.69023264
41Hepatosplenomegaly (HP:0001433)2.65731574
42Autoimmune thrombocytopenia (HP:0001973)2.61392237
43Mutism (HP:0002300)2.53151673
44Recurrent skin infections (HP:0001581)2.49444501
45Abnormality of the vasculature of the conjunctiva (HP:0008054)2.48748019
46Increased serum ferritin (HP:0003281)2.47936355
47J-shaped sella turcica (HP:0002680)2.47450805
48Pathologic fracture (HP:0002756)2.47252705
49Aortic aneurysm (HP:0004942)2.47100606
50Prolonged neonatal jaundice (HP:0006579)2.44824044
51Abnormality of the lumbar spine (HP:0100712)2.40668205
52Myositis (HP:0100614)2.37713076
53Mediastinal lymphadenopathy (HP:0100721)2.36448871
54Diminished motivation (HP:0000745)2.35780837
55Apathy (HP:0000741)2.34724660
56Thoracic kyphosis (HP:0002942)2.34579815
57Vertebral compression fractures (HP:0002953)2.32592423
58Obstructive lung disease (HP:0006536)2.32063394
59Chronic obstructive pulmonary disease (HP:0006510)2.32063394
60Xanthomatosis (HP:0000991)2.30938689
61Basal ganglia calcification (HP:0002135)2.30666254
62Dementia (HP:0000726)2.28440298
63Aortic dissection (HP:0002647)2.27947179
64Spondylolisthesis (HP:0003302)2.27242104
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.26805341
66Osteolytic defects of the hand bones (HP:0009699)2.26805341
67Increased CSF protein (HP:0002922)2.24060185
68Distal lower limb muscle weakness (HP:0009053)2.22793274
69Cervical subluxation (HP:0003308)2.21979309
70Ovoid vertebral bodies (HP:0003300)2.19441739
71Tetraparesis (HP:0002273)2.19435786
72Premature rupture of membranes (HP:0001788)2.18246747
73Peripheral demyelination (HP:0011096)2.18240882
74Progressive neurologic deterioration (HP:0002344)2.17780774
75Elevated erythrocyte sedimentation rate (HP:0003565)2.16111214
76Conjunctival telangiectasia (HP:0000524)2.14525731
77Orchitis (HP:0100796)2.11475403
78Striae distensae (HP:0001065)2.10475940
79Thick nail (HP:0001805)2.06469878
80Pustule (HP:0200039)2.06341548
81Joint stiffness (HP:0001387)2.05858014
82Global brain atrophy (HP:0002283)2.04945964
83Bone pain (HP:0002653)2.03080886
84Bone cyst (HP:0012062)2.02166255
85Recurrent fungal infections (HP:0002841)2.01194004
86Malnutrition (HP:0004395)1.99222290
87Cellulitis (HP:0100658)1.98077679
88Abnormality of the periventricular white matter (HP:0002518)1.97382634
89Personality changes (HP:0000751)1.97071117
90Petechiae (HP:0000967)1.95941806
91Frequent falls (HP:0002359)1.93811737
92Inappropriate behavior (HP:0000719)1.92355036
93Abnormality of the nasal mucosa (HP:0000433)1.92336188
94Periodontitis (HP:0000704)1.91702542
95Abnormality of iron homeostasis (HP:0011031)1.89387324
96Metaphyseal irregularity (HP:0003025)1.88974264
97Urticaria (HP:0001025)1.88421945
98Neurofibrillary tangles (HP:0002185)1.87608337
99Mucosal telangiectasiae (HP:0100579)1.86881739
100Progressive visual loss (HP:0000529)1.85600993
101Osteomyelitis (HP:0002754)1.82178774
102Supranuclear gaze palsy (HP:0000605)1.80558714
103Spontaneous hematomas (HP:0007420)1.80197006
104Disproportionate tall stature (HP:0001519)1.78355412
105* Neuronal loss in central nervous system (HP:0002529)1.76486775
106Achilles tendon contracture (HP:0001771)1.76425009
107Amyloidosis (HP:0011034)1.75168002
108Beaking of vertebral bodies (HP:0004568)1.73326167
109Abnormality of the thoracic spine (HP:0100711)1.72998904
110Cardiomegaly (HP:0001640)1.70792209
111Thin bony cortex (HP:0002753)1.69783970
112Protuberant abdomen (HP:0001538)1.69245683
113Stomatitis (HP:0010280)1.69073454
114Skin nodule (HP:0200036)1.64775783
115Hand muscle atrophy (HP:0009130)1.64076071
116Colitis (HP:0002583)1.63774086
117Mitral valve prolapse (HP:0001634)1.63020528
118Pulmonary infiltrates (HP:0002113)1.62656378
119Abnormality of the Achilles tendon (HP:0005109)1.62339187
120Restrictive lung disease (HP:0002091)1.61528920
121Deformed sella turcica (HP:0002681)1.61385430
122Upper limb amyotrophy (HP:0009129)1.61234948
123Distal upper limb amyotrophy (HP:0007149)1.61234948
124Optic neuritis (HP:0100653)1.60942145
125Retrobulbar optic neuritis (HP:0100654)1.60942145
126Segmental peripheral demyelination/remyelination (HP:0003481)1.59654113
127Deep venous thrombosis (HP:0002625)1.55820080
128Bulbar palsy (HP:0001283)1.54383097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.79250117
2TRIB33.58873159
3ERN13.42096404
4TBK12.86691081
5PKN22.74263616
6RIPK42.57558471
7BLK2.55604035
8TYK22.54799819
9KIT2.35432057
10TTN2.27980024
11PRPF4B2.27288953
12CSF1R2.19598036
13CAMK1D2.13818956
14TAOK22.12528609
15TESK21.98436091
16PAK41.94815905
17DDR21.94064854
18MAP4K11.90447099
19IRAK31.77321486
20JAK11.77274054
21NEK91.71721214
22TAOK11.71063494
23EPHB11.64732858
24IRAK41.58824522
25RIPK11.57334341
26STK101.53487382
27SCYL21.53345926
28PTK61.52229820
29ZAP701.51583842
30MAP2K31.47398493
31EPHA21.42221449
32GRK71.41318473
33CDC42BPA1.39973808
34ICK1.39501968
35MAP3K141.38659490
36CAMK1G1.36399613
37LRRK21.36190603
38HCK1.32599283
39CSK1.29861462
40MAP3K31.22883063
41CAMKK21.22250723
42LIMK11.21573707
43JAK21.15456423
44IKBKB1.15294835
45MATK1.09645936
46BMX1.08192533
47PIM21.05929202
48ARAF1.05135285
49JAK31.02315172
50IKBKE1.01801231
51FGR1.01530043
52MOS1.00732275
53CAMKK10.99683646
54MAPK150.97754233
55SMG10.97734710
56TRPM70.95622930
57FES0.95212957
58PDK20.92198280
59SYK0.88675518
60ITK0.87715893
61LCK0.85959207
62LYN0.82013198
63SIK30.80067890
64RPS6KA40.78720708
65KSR20.78179677
66NME20.76693162
67CDK60.75432783
68MAP3K60.75262562
69IRAK20.75229546
70ACVR1B0.74049456
71TESK10.73413143
72EGFR0.72945304
73TAOK30.71354716
74EPHB20.71215181
75FGFR40.71210501
76PDGFRA0.70276042
77ABL20.70112419
78SIK10.69234534
79PAK20.69181989
80BTK0.67422039
81PRKD20.66550086
82RPS6KL10.64779500
83RPS6KC10.64779500
84MAP3K110.63484201
85PRKCH0.62449912
86PDPK10.61880646
87MST1R0.61424557
88MAP2K60.58289824
89GRK60.57701619
90MAP3K100.57494614
91RET0.57307937
92FGFR30.57291355
93DMPK0.56737454
94MARK30.56081026
95PRKCD0.55329750
96PDGFRB0.55276955
97MAP3K130.55152333
98ABL10.54366090
99EEF2K0.54279039
100PDK10.53416890
101MAP3K20.52148320
102KDR0.51495444
103MARK20.51398241
104MAPK120.48665232
105CHUK0.48648745
106MAPKAPK20.48302755
107CLK10.47959596
108IGF1R0.47906992
109TXK0.47466423
110MAPK70.46094088
111PTK20.46016265
112PBK0.45744545
113MAP3K50.45493288
114RPS6KA60.45391086
115LMTK20.45227270
116PIK3CG0.45015325
117GSK3A0.44485117
118FYN0.43615282
119HIPK20.40580205
120MAPK40.40165378
121TNK20.40024271
122MAPKAPK30.39877524
123RPS6KA20.39861332
124MAP3K10.39762452
125PRKD10.39358058
126PRKG20.39136301
127DAPK30.38928039
128SRC0.37054315
129MAP3K80.37034902
130LATS20.36589985
131MAP2K20.36164281

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.32875094
2* Lysosome_Homo sapiens_hsa041423.92668070
3Staphylococcus aureus infection_Homo sapiens_hsa051503.72638019
4Other glycan degradation_Homo sapiens_hsa005113.68198689
5Leishmaniasis_Homo sapiens_hsa051402.71019951
6Osteoclast differentiation_Homo sapiens_hsa043802.42610334
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15277754
8Pertussis_Homo sapiens_hsa051332.14044777
9Phagosome_Homo sapiens_hsa041452.11728132
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04596046
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.00427256
12* Tuberculosis_Homo sapiens_hsa051521.93365040
13Malaria_Homo sapiens_hsa051441.85651647
14Rheumatoid arthritis_Homo sapiens_hsa053231.79372814
15Legionellosis_Homo sapiens_hsa051341.77441438
16Antigen processing and presentation_Homo sapiens_hsa046121.61307873
17Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60700003
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51875693
19B cell receptor signaling pathway_Homo sapiens_hsa046621.49155006
20Toxoplasmosis_Homo sapiens_hsa051451.43276258
21Salmonella infection_Homo sapiens_hsa051321.36333442
22Autoimmune thyroid disease_Homo sapiens_hsa053201.34677539
23Complement and coagulation cascades_Homo sapiens_hsa046101.28068697
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27937154
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.22416461
26Prion diseases_Homo sapiens_hsa050201.20065621
27Amoebiasis_Homo sapiens_hsa051461.18091792
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.18006496
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15468803
30Fructose and mannose metabolism_Homo sapiens_hsa000511.14191297
31Measles_Homo sapiens_hsa051621.13837354
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12622546
33Bladder cancer_Homo sapiens_hsa052191.11904736
34Collecting duct acid secretion_Homo sapiens_hsa049661.11668025
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10894847
36Shigellosis_Homo sapiens_hsa051311.10347070
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08543094
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08210451
39* Apoptosis_Homo sapiens_hsa042101.07367089
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06568858
41TNF signaling pathway_Homo sapiens_hsa046681.03665258
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03020324
43Influenza A_Homo sapiens_hsa051641.02456785
44Chronic myeloid leukemia_Homo sapiens_hsa052200.99903717
45Hematopoietic cell lineage_Homo sapiens_hsa046400.97365369
46Pentose phosphate pathway_Homo sapiens_hsa000300.97126450
47Pancreatic cancer_Homo sapiens_hsa052120.93488161
48Type I diabetes mellitus_Homo sapiens_hsa049400.93023294
49Viral myocarditis_Homo sapiens_hsa054160.90129492
50Graft-versus-host disease_Homo sapiens_hsa053320.89056034
51Caffeine metabolism_Homo sapiens_hsa002320.88467770
52Endocytosis_Homo sapiens_hsa041440.85948570
53Chemokine signaling pathway_Homo sapiens_hsa040620.85547506
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85268914
55Platelet activation_Homo sapiens_hsa046110.81915868
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79580533
57Renin-angiotensin system_Homo sapiens_hsa046140.78511719
58Hepatitis B_Homo sapiens_hsa051610.78251080
59Proteoglycans in cancer_Homo sapiens_hsa052050.77152977
60Focal adhesion_Homo sapiens_hsa045100.77029999
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72811803
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.69521199
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.69072369
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.68176785
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67758379
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.67465579
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66800667
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65952094
69Vibrio cholerae infection_Homo sapiens_hsa051100.65619808
70Sphingolipid metabolism_Homo sapiens_hsa006000.64483943
71ECM-receptor interaction_Homo sapiens_hsa045120.63826567
72Hepatitis C_Homo sapiens_hsa051600.63778034
73HIF-1 signaling pathway_Homo sapiens_hsa040660.61577886
74Acute myeloid leukemia_Homo sapiens_hsa052210.60951163
75Asthma_Homo sapiens_hsa053100.59359594
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58909561
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56566766
78VEGF signaling pathway_Homo sapiens_hsa043700.56327507
79Mineral absorption_Homo sapiens_hsa049780.56275353
80Renal cell carcinoma_Homo sapiens_hsa052110.54905053
81Adherens junction_Homo sapiens_hsa045200.54427685
82Insulin resistance_Homo sapiens_hsa049310.52455189
83PPAR signaling pathway_Homo sapiens_hsa033200.50733615
84Synaptic vesicle cycle_Homo sapiens_hsa047210.49342405
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48972092
86Small cell lung cancer_Homo sapiens_hsa052220.48927090
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46913818
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46620242
89Sulfur metabolism_Homo sapiens_hsa009200.44826648
90* Sphingolipid signaling pathway_Homo sapiens_hsa040710.44242953
91Glutathione metabolism_Homo sapiens_hsa004800.42275349
92Galactose metabolism_Homo sapiens_hsa000520.40822265
93African trypanosomiasis_Homo sapiens_hsa051430.40378084
94mTOR signaling pathway_Homo sapiens_hsa041500.40132004
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.40057491
96Type II diabetes mellitus_Homo sapiens_hsa049300.39018284
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.38209123
98Allograft rejection_Homo sapiens_hsa053300.37917664
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37785470
100Colorectal cancer_Homo sapiens_hsa052100.37188313
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36616345
102T cell receptor signaling pathway_Homo sapiens_hsa046600.36506632
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36193119
104Dilated cardiomyopathy_Homo sapiens_hsa054140.34946479
105Glioma_Homo sapiens_hsa052140.34865206
106GnRH signaling pathway_Homo sapiens_hsa049120.33843779
107Prolactin signaling pathway_Homo sapiens_hsa049170.32607358
108Herpes simplex infection_Homo sapiens_hsa051680.32199372
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31035711
110Nitrogen metabolism_Homo sapiens_hsa009100.30944323
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30144639
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.30072534
113Non-small cell lung cancer_Homo sapiens_hsa052230.29568849
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29177018
115Insulin signaling pathway_Homo sapiens_hsa049100.27682934
116Notch signaling pathway_Homo sapiens_hsa043300.27280668
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.26908949
118Epstein-Barr virus infection_Homo sapiens_hsa051690.23548637

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