CTSA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.58647118
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.58647118
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.58647118
4modulation by symbiont of host immune response (GO:0052553)6.58647118
5positive regulation by symbiont of host defense response (GO:0052509)6.58647118
6modulation by symbiont of host defense response (GO:0052031)6.58647118
7regulation of interferon-beta biosynthetic process (GO:0045357)5.96338895
8neutrophil activation involved in immune response (GO:0002283)5.22800367
9macrophage activation involved in immune response (GO:0002281)5.21943183
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80688409
11microglial cell activation (GO:0001774)4.45846353
12positive regulation of interferon-alpha production (GO:0032727)4.43149890
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.26469092
14mannose metabolic process (GO:0006013)4.19082624
15regulation of interferon-alpha production (GO:0032647)4.17502335
16response to host immune response (GO:0052572)4.05240566
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.05240566
18immunoglobulin mediated immune response (GO:0016064)3.91466696
19response to peptidoglycan (GO:0032494)3.87049398
20macrophage activation (GO:0042116)3.79639843
21respiratory burst (GO:0045730)3.73163678
22pinocytosis (GO:0006907)3.70699837
23regulation of B cell receptor signaling pathway (GO:0050855)3.67317560
24positive regulation of antigen processing and presentation (GO:0002579)3.64461872
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.64128396
26response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.60317202
27response to host (GO:0075136)3.60317202
28response to host defenses (GO:0052200)3.60317202
29oligosaccharide catabolic process (GO:0009313)3.47112577
30myeloid cell activation involved in immune response (GO:0002275)3.44780476
31apoptotic cell clearance (GO:0043277)3.42429637
32regulation of mononuclear cell migration (GO:0071675)3.39583300
33keratan sulfate catabolic process (GO:0042340)3.37505954
34barbed-end actin filament capping (GO:0051016)3.30569705
35detection of molecule of bacterial origin (GO:0032490)3.29078962
36positive regulation of interferon-beta production (GO:0032728)3.25989158
37regulation of cholesterol storage (GO:0010885)3.21544436
38regulation of antigen processing and presentation (GO:0002577)3.16475322
39amyloid precursor protein catabolic process (GO:0042987)3.14317504
40glycosphingolipid catabolic process (GO:0046479)3.10957900
41hyaluronan catabolic process (GO:0030214)3.10884415
42granulocyte activation (GO:0036230)3.09291452
43cellular response to thyroid hormone stimulus (GO:0097067)3.09021984
44peptide catabolic process (GO:0043171)3.07124765
45negative regulation of mast cell activation (GO:0033004)3.07015016
46neutrophil activation (GO:0042119)3.06681583
47ceramide catabolic process (GO:0046514)3.02087454
48positive regulation of cellular amide metabolic process (GO:0034250)3.01658118
49response to thyroid hormone (GO:0097066)2.99415329
50regulation of mast cell degranulation (GO:0043304)2.97211175
51positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.92988352
52protein localization to endosome (GO:0036010)2.90992008
53positive regulation of mast cell activation (GO:0033005)2.90979820
54positive regulation of receptor recycling (GO:0001921)2.87569666
55low-density lipoprotein particle remodeling (GO:0034374)2.86817963
56folic acid transport (GO:0015884)2.86762798
57amino sugar catabolic process (GO:0046348)2.86107633
58production of molecular mediator involved in inflammatory response (GO:0002532)2.84996820
59regulation of interleukin-8 biosynthetic process (GO:0045414)2.84565897
60regulation of integrin-mediated signaling pathway (GO:2001044)2.84328957
61regulation of platelet activation (GO:0010543)2.83442271
62regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82437411
63glycolipid catabolic process (GO:0019377)2.81781335
64regulation of mast cell activation involved in immune response (GO:0033006)2.81525125
65lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81491614
66I-kappaB phosphorylation (GO:0007252)2.80499650
67adenosine receptor signaling pathway (GO:0001973)2.78363682
68leukotriene metabolic process (GO:0006691)2.76815561
69regulation of mast cell activation (GO:0033003)2.74788310
70virion attachment to host cell (GO:0019062)2.73800847
71adhesion of symbiont to host cell (GO:0044650)2.73800847
72negative regulation of platelet activation (GO:0010544)2.72203598
73hydrogen peroxide biosynthetic process (GO:0050665)2.71180735
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.70119628
75positive regulation of leukocyte degranulation (GO:0043302)2.69867882
76platelet degranulation (GO:0002576)2.68435204
77positive regulation of monocyte chemotaxis (GO:0090026)2.68089252
78angiogenesis involved in wound healing (GO:0060055)2.67896930
79negative regulation of interleukin-6 production (GO:0032715)2.67764005
80low-density lipoprotein particle clearance (GO:0034383)2.66403287
81regulation of macrophage chemotaxis (GO:0010758)2.65771216
82regulation of early endosome to late endosome transport (GO:2000641)2.65746415
83positive regulation of chemokine biosynthetic process (GO:0045080)2.64074162
84negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.63783362
85positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.63739464
86positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.63610273
87negative regulation of interleukin-12 production (GO:0032695)2.62260605
88positive regulation of macrophage differentiation (GO:0045651)2.61765018
89B cell mediated immunity (GO:0019724)2.61714076
90cellular extravasation (GO:0045123)2.60819580
91fibril organization (GO:0097435)2.59784900
92positive regulation of B cell differentiation (GO:0045579)2.59672722
93sphingolipid catabolic process (GO:0030149)2.59579420
94membrane lipid catabolic process (GO:0046466)2.59561344
95regulation of superoxide anion generation (GO:0032928)2.59365460
96regulation of leukocyte degranulation (GO:0043300)2.59157860
97regulation of cholesterol esterification (GO:0010872)2.58756094
98positive regulation of toll-like receptor signaling pathway (GO:0034123)2.58732308
99response to lipoprotein particle (GO:0055094)2.58195968
100positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57539194
101myeloid leukocyte activation (GO:0002274)2.56161114
102positive regulation of extracellular matrix organization (GO:1903055)2.55859748
103response to muramyl dipeptide (GO:0032495)2.55761858
104regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55550004
105negative regulation of nitric oxide biosynthetic process (GO:0045019)2.55121157
106negative regulation of erythrocyte differentiation (GO:0045647)2.55093398
107response to laminar fluid shear stress (GO:0034616)2.54409843
108Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54136879
109regulation of interferon-beta production (GO:0032648)2.54075007
110antigen processing and presentation of endogenous antigen (GO:0019883)2.53911570
111adhesion of symbiont to host (GO:0044406)2.53641786
112lymphocyte chemotaxis (GO:0048247)2.52964093
113regulation of platelet aggregation (GO:0090330)2.52638586
114glycosylceramide metabolic process (GO:0006677)2.52607630
115phagosome maturation (GO:0090382)2.52409842
116N-acetylneuraminate metabolic process (GO:0006054)2.52145082
117negative regulation of lipid storage (GO:0010888)2.52143752
118positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51404063
119platelet aggregation (GO:0070527)2.51025400
120negative regulation of protein localization to plasma membrane (GO:1903077)2.50481034
121positive regulation of gamma-delta T cell activation (GO:0046645)2.49646020
122phagocytosis, engulfment (GO:0006911)2.49409903
123antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49316024
124thrombin receptor signaling pathway (GO:0070493)2.49215684
125cyclooxygenase pathway (GO:0019371)2.48872056
126positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47938180
127regulation of extracellular matrix disassembly (GO:0010715)2.47361385
128leukocyte mediated cytotoxicity (GO:0001909)2.47267015
129negative regulation of interleukin-17 production (GO:0032700)2.47059803
130regulation of monocyte chemotaxis (GO:0090025)2.46399438
131regulation of membrane protein ectodomain proteolysis (GO:0051043)2.46184754
132regulation of T-helper 2 cell differentiation (GO:0045628)2.46104565
133cytidine catabolic process (GO:0006216)2.45932922
134cytidine deamination (GO:0009972)2.45932922
135cytidine metabolic process (GO:0046087)2.45932922
136positive regulation of mast cell activation involved in immune response (GO:0033008)2.45843646
137regulation of integrin activation (GO:0033623)2.44762080
138triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.43467236
139lipoxygenase pathway (GO:0019372)2.43401315
140negative regulation of homotypic cell-cell adhesion (GO:0034111)2.42269858
141fibrinolysis (GO:0042730)2.42025627
142negative regulation of cell killing (GO:0031342)2.41447540
143negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.41447540
144stress fiber assembly (GO:0043149)2.40943493
145extracellular fibril organization (GO:0043206)2.39211693
146negative regulation of cytokine production involved in immune response (GO:0002719)2.38734907
147positive regulation of coagulation (GO:0050820)2.36465149
148positive regulation of hemostasis (GO:1900048)2.34688170
149positive regulation of blood coagulation (GO:0030194)2.34688170
150blood coagulation, intrinsic pathway (GO:0007597)2.30599786
151myeloid dendritic cell differentiation (GO:0043011)2.29144728
152regulation of vitamin D biosynthetic process (GO:0060556)2.28374779
153regulation of podosome assembly (GO:0071801)2.28032916
154fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.27348642
155lysosome organization (GO:0007040)2.27112989
156lytic vacuole organization (GO:0080171)2.27112989
157regulation of T-helper 1 cell differentiation (GO:0045625)2.26793557
158skin morphogenesis (GO:0043589)2.24752706
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.22984319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.96989816
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.83280971
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.61807098
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.96809356
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.77084242
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32434761
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.24536323
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.09272725
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75043701
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51211816
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45381374
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32975970
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14232701
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12937580
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10096396
16SPI1_23547873_ChIP-Seq_NB4_Human2.08678851
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07132986
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.94656163
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85166437
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.82694644
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76673620
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72856537
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.72362930
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.69161997
25RXR_22158963_ChIP-Seq_LIVER_Mouse1.69122570
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67711533
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67338986
28SPI1_23127762_ChIP-Seq_K562_Human1.67120831
29SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67088229
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66283749
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65885650
32GATA1_19941827_ChIP-Seq_MEL_Mouse1.63502088
33CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60804072
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59364641
35VDR_24763502_ChIP-Seq_THP-1_Human1.59153874
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58691342
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58494357
38GATA1_19941826_ChIP-Seq_K562_Human1.57452205
39TFEB_21752829_ChIP-Seq_HELA_Human1.57431671
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56904687
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56656929
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56187496
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.53791327
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50749584
45VDR_21846776_ChIP-Seq_THP-1_Human1.50656444
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49157571
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47986519
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47313829
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.42826243
50CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42602764
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42227700
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.41852836
53RACK7_27058665_Chip-Seq_MCF-7_Human1.41061175
54PU_27001747_Chip-Seq_BMDM_Mouse1.39766872
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37777057
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37357456
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36532406
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33974997
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32941639
60CLOCK_20551151_ChIP-Seq_293T_Human1.32762312
61MAF_26560356_Chip-Seq_TH1_Human1.32399164
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31284758
63VDR_24787735_ChIP-Seq_THP-1_Human1.30882939
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30683866
65TCF7_22412390_ChIP-Seq_EML_Mouse1.28530923
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28310607
67GATA1_22025678_ChIP-Seq_K562_Human1.27557010
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27397421
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26180851
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24392656
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.23144359
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22425055
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21106706
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20992713
75GATA2_19941826_ChIP-Seq_K562_Human1.18036052
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.17152383
77ZNF263_19887448_ChIP-Seq_K562_Human1.15073884
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14347181
79MYB_26560356_Chip-Seq_TH2_Human1.13808906
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12428764
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.12296213
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09886911
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08724188
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07115382
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06435641
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05861138
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05044058
88BCOR_27268052_Chip-Seq_Bcells_Human1.04396741
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04241110
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04100130
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03983696
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03982540
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03582460
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03492993
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03186955
96KDM2B_26808549_Chip-Seq_DND41_Human1.02993948
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02792068
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02657119
99MYB_26560356_Chip-Seq_TH1_Human1.02419941
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01719077
101NCOR1_26117541_ChIP-Seq_K562_Human1.01465882
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01349135
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99600842
104GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98983735
105LXR_22292898_ChIP-Seq_THP-1_Human0.98390656
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97878514
107GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96177192
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95439571
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94997210
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94106147
111RUNX_20019798_ChIP-Seq_JUKART_Human0.93937293
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.92737226
113SCL_19346495_ChIP-Seq_HPC-7_Human0.91750804
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91396468
115UTX_26944678_Chip-Seq_JUKART_Human0.90603560
116SPI1_20517297_ChIP-Seq_HL60_Human0.90042290
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89960521
118EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89198988
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88331749
120SOX2_20726797_ChIP-Seq_SW620_Human0.87756814
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87682774
122GATA3_27048872_Chip-Seq_THYMUS_Human0.87177043
123GATA3_26560356_Chip-Seq_TH2_Human0.86793973
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85711749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005058_abnormal_lysosome_morphology5.58876032
2MP0009840_abnormal_foam_cell4.03630107
3MP0003172_abnormal_lysosome_physiology3.29908944
4MP0001835_abnormal_antigen_presentation3.17889554
5MP0006082_CNS_inflammation3.01224878
6MP0008438_abnormal_cutaneous_collagen2.97282052
7MP0003191_abnormal_cellular_cholesterol2.94705474
8MP0003436_decreased_susceptibility_to2.84735932
9MP0002419_abnormal_innate_immunity2.74920468
10MP0003303_peritoneal_inflammation2.47221024
11MP0002148_abnormal_hypersensitivity_rea2.37506228
12MP0002139_abnormal_hepatobiliary_system2.32003789
13MP0005000_abnormal_immune_tolerance2.20814322
14MP0000604_amyloidosis2.13476156
15MP0008004_abnormal_stomach_pH2.08012432
16MP0001533_abnormal_skeleton_physiology2.04180535
17MP0005025_abnormal_response_to2.02577119
18MP0005257_abnormal_intraocular_pressure2.01248114
19MP0009785_altered_susceptibility_to1.98913386
20MP0002452_abnormal_antigen_presenting1.96257275
21MP0002877_abnormal_melanocyte_morpholog1.96143570
22MP0006054_spinal_hemorrhage1.94422392
23MP0003690_abnormal_glial_cell1.94017900
24MP0005387_immune_system_phenotype1.92613858
25MP0001790_abnormal_immune_system1.92613858
26MP0005464_abnormal_platelet_physiology1.89074126
27MP0004510_myositis1.81032325
28MP0000343_altered_response_to1.73650878
29MP0003724_increased_susceptibility_to1.72071825
30MP0002723_abnormal_immune_serum1.71767771
31MP0005671_abnormal_response_to1.70551186
32MP0001800_abnormal_humoral_immune1.64697766
33MP0009333_abnormal_splenocyte_physiolog1.64086234
34MP0000685_abnormal_immune_system1.57174908
35MP0005365_abnormal_bile_salt1.54082901
36MP0001819_abnormal_immune_cell1.52876321
37MP0003448_altered_tumor_morphology1.52045829
38MP0008469_abnormal_protein_level1.52019099
39MP0002420_abnormal_adaptive_immunity1.51762770
40MP0003566_abnormal_cell_adhesion1.51685950
41MP0002405_respiratory_system_inflammati1.51203928
42MP0002998_abnormal_bone_remodeling1.47052102
43MP0003279_aneurysm1.44811297
44MP0001958_emphysema1.44429832
45MP0001845_abnormal_inflammatory_respons1.44166286
46MP0008260_abnormal_autophagy1.41341350
47MP0003300_gastrointestinal_ulcer1.40471045
48MP0004947_skin_inflammation1.39944910
49MP0003075_altered_response_to1.39563249
50MP0001542_abnormal_bone_strength1.34903087
51MP0003705_abnormal_hypodermis_morpholog1.33469783
52MP0001853_heart_inflammation1.32690858
53MP0003806_abnormal_nucleotide_metabolis1.31291881
54MP0005310_abnormal_salivary_gland1.20383121
55MP0000465_gastrointestinal_hemorrhage1.19893624
56MP0003091_abnormal_cell_migration1.18829258
57MP0002933_joint_inflammation1.16783135
58MP0005390_skeleton_phenotype1.16509208
59MP0009764_decreased_sensitivity_to1.15032378
60MP0010307_abnormal_tumor_latency1.14721449
61MP0000858_altered_metastatic_potential1.13507589
62MP0005166_decreased_susceptibility_to1.09978517
63MP0003186_abnormal_redox_activity1.09395852
64MP0000716_abnormal_immune_system1.08206762
65MP0005023_abnormal_wound_healing1.07184128
66MP0003329_amyloid_beta_deposits1.05602867
67MP0003183_abnormal_peptide_metabolism1.04818226
68* MP0000689_abnormal_spleen_morphology1.03137272
69MP0009278_abnormal_bone_marrow1.02970343
70MP0009643_abnormal_urine_homeostasis1.01775960
71MP0003828_pulmonary_edema0.98141203
72MP0005275_abnormal_skin_tensile0.96343845
73MP0010155_abnormal_intestine_physiology0.96048994
74MP0004272_abnormal_basement_membrane0.95887592
75MP0003656_abnormal_erythrocyte_physiolo0.95763224
76MP0005451_abnormal_body_composition0.95596471
77MP0000920_abnormal_myelination0.93921266
78MP0004019_abnormal_vitamin_homeostasis0.92144966
79MP0005164_abnormal_response_to0.91277995
80MP0000249_abnormal_blood_vessel0.91106464
81* MP0002136_abnormal_kidney_physiology0.90860674
82MP0005083_abnormal_biliary_tract0.90121732
83MP0003795_abnormal_bone_structure0.89677770
84MP0002429_abnormal_blood_cell0.89497473
85MP0001851_eye_inflammation0.88171446
86MP0000609_abnormal_liver_physiology0.87411608
87MP0002295_abnormal_pulmonary_circulatio0.85778423
88MP0005670_abnormal_white_adipose0.85313478
89MP0003195_calcinosis0.84040371
90* MP0002722_abnormal_immune_system0.83604271
91MP0001849_ear_inflammation0.83193721
92MP0003879_abnormal_hair_cell0.83112423
93MP0005408_hypopigmentation0.82714076
94MP0002398_abnormal_bone_marrow0.82262531
95MP0009763_increased_sensitivity_to0.80546652
96MP0005332_abnormal_amino_acid0.79657727
97MP0004883_abnormal_blood_vessel0.79196626
98MP0005165_increased_susceptibility_to0.78760115
99MP0005167_abnormal_blood-brain_barrier0.78311789
100MP0001663_abnormal_digestive_system0.77275992
101* MP0001756_abnormal_urination0.77227625
102MP0000015_abnormal_ear_pigmentation0.77195081
103MP0004782_abnormal_surfactant_physiolog0.77036674
104MP0005360_urolithiasis0.76724756
105MP0005319_abnormal_enzyme/_coenzyme0.75132439
106MP0000767_abnormal_smooth_muscle0.74814688
107MP0003950_abnormal_plasma_membrane0.73232683
108MP0002118_abnormal_lipid_homeostasis0.72961591
109MP0002090_abnormal_vision0.71725458
110MP0010329_abnormal_lipoprotein_level0.71616413
111MP0005397_hematopoietic_system_phenotyp0.70941444
112MP0001545_abnormal_hematopoietic_system0.70941444
113MP0000569_abnormal_digit_pigmentation0.70861221
114MP0000371_diluted_coat_color0.68968184
115MP0001243_abnormal_dermal_layer0.68948906
116MP0002254_reproductive_system_inflammat0.68759731
117MP0003453_abnormal_keratinocyte_physiol0.68204676

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)6.60278095
2Systemic lupus erythematosus (HP:0002725)6.27215422
3Increased cerebral lipofuscin (HP:0011813)6.05357530
4Recurrent abscess formation (HP:0002722)5.75755681
5Increased neuronal autofluorescent lipopigment (HP:0002074)5.42920648
6Abnormality of liposaccharide metabolism (HP:0010968)5.17288952
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.17288952
8Abnormality of glycolipid metabolism (HP:0010969)5.17288952
9Recurrent bacterial skin infections (HP:0005406)5.09468050
10* Dysostosis multiplex (HP:0000943)4.96940448
11Eczematoid dermatitis (HP:0000976)4.59899505
12Mucopolysacchariduria (HP:0008155)4.46009390
13Urinary glycosaminoglycan excretion (HP:0003541)4.46009390
14Abnormality of macrophages (HP:0004311)4.44961634
15Glomerulonephritis (HP:0000099)4.44196513
16Axonal loss (HP:0003447)4.32888705
17Abnormality of mucopolysaccharide metabolism (HP:0011020)4.20611904
18Abnormality of polysaccharide metabolism (HP:0011012)4.20611904
19Abnormality of glycosaminoglycan metabolism (HP:0004371)4.20611904
20Prolonged bleeding time (HP:0003010)4.14572303
21Menorrhagia (HP:0000132)4.07514498
22Recurrent gram-negative bacterial infections (HP:0005420)4.03842681
23Increased mean platelet volume (HP:0011877)3.52544067
24Epistaxis (HP:0000421)3.52070363
25Gingival bleeding (HP:0000225)3.51037426
26Abnormal platelet volume (HP:0011876)3.48339200
27Osteolytic defects of the hand bones (HP:0009699)3.40321880
28Osteolytic defects of the phalanges of the hand (HP:0009771)3.40321880
29Complement deficiency (HP:0004431)3.35200584
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.27305362
31Pustule (HP:0200039)3.20556086
32Abnormality of complement system (HP:0005339)3.19774309
33Disinhibition (HP:0000734)3.15362818
34Premature rupture of membranes (HP:0001788)3.08203625
35Asymmetric septal hypertrophy (HP:0001670)2.92306666
36Recurrent skin infections (HP:0001581)2.90339041
37Gingivitis (HP:0000230)2.89679850
38Loss of speech (HP:0002371)2.89469864
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.87891149
40Myocardial infarction (HP:0001658)2.80947165
41Nuclear cataract (HP:0100018)2.78913176
42Neurofibrillary tangles (HP:0002185)2.74670115
43Nephritis (HP:0000123)2.65162527
44Abnormal platelet function (HP:0011869)2.64408875
45Impaired platelet aggregation (HP:0003540)2.64408875
46Chronic obstructive pulmonary disease (HP:0006510)2.61532284
47Obstructive lung disease (HP:0006536)2.61532284
48Thick nail (HP:0001805)2.60608457
49Vertebral compression fractures (HP:0002953)2.56005215
50Petechiae (HP:0000967)2.50273682
51Autoimmune thrombocytopenia (HP:0001973)2.49513062
52Protrusio acetabuli (HP:0003179)2.49249388
53Increased serum ferritin (HP:0003281)2.47749863
54Personality changes (HP:0000751)2.47185976
55Pathologic fracture (HP:0002756)2.45740893
56Cervical subluxation (HP:0003308)2.41880949
57Mediastinal lymphadenopathy (HP:0100721)2.38377321
58Progressive neurologic deterioration (HP:0002344)2.36286681
59Ovoid vertebral bodies (HP:0003300)2.35745797
60Spondylolisthesis (HP:0003302)2.32511322
61Elevated erythrocyte sedimentation rate (HP:0003565)2.32466743
62Abnormality of the common coagulation pathway (HP:0010990)2.31709218
63Global brain atrophy (HP:0002283)2.29194841
64Hyperlipoproteinemia (HP:0010980)2.27705912
65Myositis (HP:0100614)2.25725711
66Interstitial pulmonary disease (HP:0006530)2.25712942
67Agnosia (HP:0010524)2.23876374
68Deep venous thrombosis (HP:0002625)2.22215537
69* Hepatosplenomegaly (HP:0001433)2.21206944
70Mitral stenosis (HP:0001718)2.19709087
71Periodontitis (HP:0000704)2.19413545
72Retinal atrophy (HP:0001105)2.19098899
73Cerebral aneurysm (HP:0004944)2.17712275
74Prolonged neonatal jaundice (HP:0006579)2.15746370
75Peripheral demyelination (HP:0011096)2.15440958
76Abnormality of iron homeostasis (HP:0011031)2.15308673
77Recurrent fungal infections (HP:0002841)2.15050468
78Joint stiffness (HP:0001387)2.14533946
79Thoracic kyphosis (HP:0002942)2.11819464
80Stomatitis (HP:0010280)2.10877043
81Abnormality of the Achilles tendon (HP:0005109)2.10771734
82Upper motor neuron abnormality (HP:0002127)2.10607634
83Basal ganglia calcification (HP:0002135)2.10589615
84Abnormality of the lumbar spine (HP:0100712)2.09565149
85Progressive visual loss (HP:0000529)2.09479211
86Spontaneous hematomas (HP:0007420)2.04186888
87Segmental peripheral demyelination/remyelination (HP:0003481)2.01342542
88J-shaped sella turcica (HP:0002680)2.01302847
89Bruising susceptibility (HP:0000978)2.00304787
90Mutism (HP:0002300)1.97745108
91Beaking of vertebral bodies (HP:0004568)1.95965394
92Neuronal loss in central nervous system (HP:0002529)1.91493523
93Orchitis (HP:0100796)1.91484817
94Hemorrhage of the eye (HP:0011885)1.90493452
95Cerebral inclusion bodies (HP:0100314)1.88827907
96Xanthomatosis (HP:0000991)1.88178572
97Vascular calcification (HP:0004934)1.87307026
98Bone pain (HP:0002653)1.86657152
99Cardiovascular calcification (HP:0011915)1.85559639
100Distal lower limb muscle weakness (HP:0009053)1.84210056
101Prostate neoplasm (HP:0100787)1.83261952
102Osteomyelitis (HP:0002754)1.83071035
103Arterial tortuosity (HP:0005116)1.82541634
104Diminished motivation (HP:0000745)1.81716474
105Hematochezia (HP:0002573)1.80802472
106Urticaria (HP:0001025)1.80482113
107Achilles tendon contracture (HP:0001771)1.79484589
108Purpura (HP:0000979)1.79216310
109Polycythemia (HP:0001901)1.78847640
110Apathy (HP:0000741)1.78792376
111Vascular tortuosity (HP:0004948)1.78438107
112Poor head control (HP:0002421)1.78272712
113Nausea (HP:0002018)1.78153395
114Recurrent viral infections (HP:0004429)1.77179262
115Cellulitis (HP:0100658)1.77058119
116Cardiomegaly (HP:0001640)1.77020077
117Leukocytosis (HP:0001974)1.71431081
118Joint hemorrhage (HP:0005261)1.70319551
119Abnormality of transition element cation homeostasis (HP:0011030)1.69817098
120Abnormality of the distal phalanges of the toes (HP:0010182)1.69441835
121Joint swelling (HP:0001386)1.68546800
122Supranuclear gaze palsy (HP:0000605)1.68034041
123Premature loss of primary teeth (HP:0006323)1.67766484
124Recurrent pneumonia (HP:0006532)1.67349668
125Distal lower limb amyotrophy (HP:0008944)1.67026399
126Hypertriglyceridemia (HP:0002155)1.67011898
127Retrobulbar optic neuritis (HP:0100654)1.65072479
128Optic neuritis (HP:0100653)1.65072479
129Pulmonary infiltrates (HP:0002113)1.64106421
130Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63106887
131Peritonitis (HP:0002586)1.61828539
132Amyloidosis (HP:0011034)1.59065365
133Aortic dissection (HP:0002647)1.57665838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.96102481
2BLK3.79164579
3IRAK33.03454933
4ERN13.00735338
5TYK22.81839129
6TBK12.76962327
7KIT2.67061282
8TAOK32.61398538
9MAP4K12.50523254
10CSF1R2.29739715
11IRAK42.20994779
12TAOK22.15732102
13TESK12.04694965
14EPHB11.99376433
15STK101.93809995
16MYLK1.92281504
17RIPK41.85820850
18TRIB31.84963250
19MAP3K141.83633443
20NME21.75540583
21PRPF4B1.68933076
22NEK91.68843692
23PIM21.68660384
24ZAP701.64531152
25TTN1.53828801
26GRK71.53589235
27JAK11.48358711
28IKBKB1.47202077
29TAOK11.46509757
30FGR1.41993722
31CDC42BPA1.41929884
32CSK1.36150562
33PAK41.35277236
34MAP2K31.33474438
35MET1.32842056
36CAMKK21.31722814
37HCK1.31618626
38PBK1.28837841
39SIK11.28512764
40CAMK1D1.27080236
41MAP3K31.25697133
42ITK1.19436624
43BMX1.17366939
44TXK1.16175974
45LMTK21.14905909
46IKBKE1.13854904
47MOS1.12906204
48MAPKAPK31.12568694
49LYN1.11440122
50BTK1.09755835
51LIMK11.09752126
52PDGFRA1.09540902
53BMPR21.05783964
54TESK21.03654639
55MAP3K11.02453601
56LRRK21.02188047
57CLK11.01928457
58PKN21.00280526
59ABL21.00055434
60BUB10.98542514
61JAK20.97152550
62JAK30.95445390
63LCK0.95010355
64SYK0.93417526
65TEC0.89935189
66MST1R0.89426191
67TRPM70.86222112
68KDR0.84177125
69SIK30.82085685
70PTK60.80891852
71ICK0.77642643
72PRKD20.76374199
73RPS6KA40.75137579
74SCYL20.72626815
75FES0.72163548
76ACVR1B0.71733585
77FGFR40.71411804
78PRKCD0.69798637
79PIM10.69677830
80PDK10.68966769
81MAP3K110.68822132
82PRKG20.66548046
83EGFR0.64642621
84MAP3K50.64173121
85ARAF0.63694300
86IRAK20.63039023
87MST40.63006571
88GRK50.62689072
89ILK0.61467842
90MAP2K20.60655595
91IRAK10.60194300
92CAMK1G0.59241150
93MARK30.58478891
94EPHB20.58300715
95MAP3K80.57987870
96MAPK110.57227879
97EIF2AK10.55754193
98MATK0.55598727
99RIPK10.54857928
100ADRBK20.54853184
101STK30.53999060
102DAPK30.53466246
103ABL10.53199734
104PDGFRB0.52710857
105EPHA20.52014755
106PIK3CG0.51257668
107HIPK20.48098044
108KSR20.47186874
109FER0.46237967
110CAMKK10.46024414
111CHUK0.45619197
112TNK20.43406199
113TSSK60.43363148
114MAP3K60.43218437
115MAPKAPK20.42417468
116EIF2AK20.42269512
117PDPK10.42002280
118MAP2K60.41739868
119PDK20.41522520
120IGF1R0.40857823
121PAK10.39966745
122PAK20.38948167
123STK40.37562267
124PTK2B0.36541525
125MAP3K130.35489978
126GSK3A0.35389258
127DYRK1B0.34716262
128BCKDK0.32947030
129PTK20.32581834
130MAPK150.31879753
131GRK60.31778222
132DDR20.30877091
133PRKD10.30511309
134CDK60.30145481

Predicted pathways (KEGG)

RankGene SetZ-score
1* Lysosome_Homo sapiens_hsa041424.38824162
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.31899663
3Other glycan degradation_Homo sapiens_hsa005114.20271618
4Staphylococcus aureus infection_Homo sapiens_hsa051504.15717205
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.47262145
6Leishmaniasis_Homo sapiens_hsa051402.26128318
7Malaria_Homo sapiens_hsa051442.03763437
8Phagosome_Homo sapiens_hsa041452.01051380
9Osteoclast differentiation_Homo sapiens_hsa043801.99539841
10Tuberculosis_Homo sapiens_hsa051521.90334699
11Antigen processing and presentation_Homo sapiens_hsa046121.89245744
12Pertussis_Homo sapiens_hsa051331.89173800
13Rheumatoid arthritis_Homo sapiens_hsa053231.88934820
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84626892
15Complement and coagulation cascades_Homo sapiens_hsa046101.83604778
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79655190
17Legionellosis_Homo sapiens_hsa051341.61264787
18Vitamin B6 metabolism_Homo sapiens_hsa007501.53122050
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52423176
20Caffeine metabolism_Homo sapiens_hsa002321.51846544
21Sulfur metabolism_Homo sapiens_hsa009201.47880180
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47655586
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44937976
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.44339413
25B cell receptor signaling pathway_Homo sapiens_hsa046621.25148518
26Steroid biosynthesis_Homo sapiens_hsa001001.21300146
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20907824
28Sphingolipid metabolism_Homo sapiens_hsa006001.17815183
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16105460
30Apoptosis_Homo sapiens_hsa042101.14850237
31Graft-versus-host disease_Homo sapiens_hsa053321.13765757
32Measles_Homo sapiens_hsa051621.10058785
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08418383
34Salmonella infection_Homo sapiens_hsa051321.06918414
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.06029908
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04264521
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.03870894
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03405893
39Prion diseases_Homo sapiens_hsa050201.01172764
40Bladder cancer_Homo sapiens_hsa052191.00688269
41Toxoplasmosis_Homo sapiens_hsa051450.99010398
42Collecting duct acid secretion_Homo sapiens_hsa049660.96242821
43Folate biosynthesis_Homo sapiens_hsa007900.96164992
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95466878
45Mineral absorption_Homo sapiens_hsa049780.94166086
46Shigellosis_Homo sapiens_hsa051310.92814884
47Vitamin digestion and absorption_Homo sapiens_hsa049770.92196399
48Hematopoietic cell lineage_Homo sapiens_hsa046400.90006004
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86950467
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86939273
51ECM-receptor interaction_Homo sapiens_hsa045120.83118727
52Influenza A_Homo sapiens_hsa051640.82825722
53Regulation of autophagy_Homo sapiens_hsa041400.81165796
54Galactose metabolism_Homo sapiens_hsa000520.80058430
55Acute myeloid leukemia_Homo sapiens_hsa052210.80005319
56Pentose phosphate pathway_Homo sapiens_hsa000300.78504959
57Allograft rejection_Homo sapiens_hsa053300.78395247
58Amoebiasis_Homo sapiens_hsa051460.77881221
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77236880
60Type I diabetes mellitus_Homo sapiens_hsa049400.76451110
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76127532
62Arachidonic acid metabolism_Homo sapiens_hsa005900.75998802
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.75512755
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72985128
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.67100451
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65983369
67Endocytosis_Homo sapiens_hsa041440.65842773
68TNF signaling pathway_Homo sapiens_hsa046680.64179075
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63971174
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.61895373
71Asthma_Homo sapiens_hsa053100.61764959
72Fructose and mannose metabolism_Homo sapiens_hsa000510.60214773
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59954122
74Ether lipid metabolism_Homo sapiens_hsa005650.59886013
75Chemokine signaling pathway_Homo sapiens_hsa040620.58933865
76Focal adhesion_Homo sapiens_hsa045100.58799834
77Histidine metabolism_Homo sapiens_hsa003400.58161070
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57875814
79Viral myocarditis_Homo sapiens_hsa054160.57748199
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55826005
81VEGF signaling pathway_Homo sapiens_hsa043700.55464728
82Starch and sucrose metabolism_Homo sapiens_hsa005000.52513275
83Hepatitis C_Homo sapiens_hsa051600.51830972
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51070572
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.50016265
86PPAR signaling pathway_Homo sapiens_hsa033200.49312062
87Hepatitis B_Homo sapiens_hsa051610.47970735
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.47820285
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46905071
90T cell receptor signaling pathway_Homo sapiens_hsa046600.46755315
91Primary immunodeficiency_Homo sapiens_hsa053400.46103270
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45409486
93Herpes simplex infection_Homo sapiens_hsa051680.44933101
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.43719645
95African trypanosomiasis_Homo sapiens_hsa051430.43311459
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.43290117
97Glutathione metabolism_Homo sapiens_hsa004800.41295656
98Fatty acid elongation_Homo sapiens_hsa000620.39384306
99Non-small cell lung cancer_Homo sapiens_hsa052230.36410416
100Insulin resistance_Homo sapiens_hsa049310.36345949
101Small cell lung cancer_Homo sapiens_hsa052220.35868886
102Selenocompound metabolism_Homo sapiens_hsa004500.35603796
103Chronic myeloid leukemia_Homo sapiens_hsa052200.35378646
104Pancreatic cancer_Homo sapiens_hsa052120.35215305
105Vibrio cholerae infection_Homo sapiens_hsa051100.34939756
106N-Glycan biosynthesis_Homo sapiens_hsa005100.34773498
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34080963
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33086031
109ABC transporters_Homo sapiens_hsa020100.33033828
110Proteasome_Homo sapiens_hsa030500.32971542
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32619745
112Peroxisome_Homo sapiens_hsa041460.32226863
113HIF-1 signaling pathway_Homo sapiens_hsa040660.32064433
114Fat digestion and absorption_Homo sapiens_hsa049750.31691197
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30734535
116Proteoglycans in cancer_Homo sapiens_hsa052050.29442043
117Autoimmune thyroid disease_Homo sapiens_hsa053200.28768673
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28701893
119Platelet activation_Homo sapiens_hsa046110.28395905
120Epstein-Barr virus infection_Homo sapiens_hsa051690.27949555
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24753540

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