CTH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.59904339
2L-phenylalanine catabolic process (GO:0006559)7.59904339
3L-phenylalanine metabolic process (GO:0006558)7.33282092
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.33282092
5aromatic amino acid family catabolic process (GO:0009074)6.97171108
6indole-containing compound catabolic process (GO:0042436)6.38651412
7indolalkylamine catabolic process (GO:0046218)6.38651412
8tryptophan catabolic process (GO:0006569)6.38651412
9kynurenine metabolic process (GO:0070189)6.21846901
10tryptophan metabolic process (GO:0006568)6.00934842
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.96916791
12glyoxylate metabolic process (GO:0046487)5.96717303
13bile acid biosynthetic process (GO:0006699)5.88731286
14serine family amino acid catabolic process (GO:0009071)5.84922234
15urea metabolic process (GO:0019627)5.83764276
16urea cycle (GO:0000050)5.83764276
17* cysteine metabolic process (GO:0006534)5.41351102
18nitrogen cycle metabolic process (GO:0071941)5.37942704
19negative regulation of fibrinolysis (GO:0051918)5.37705811
20glycine metabolic process (GO:0006544)5.25293728
21* sulfur amino acid catabolic process (GO:0000098)5.23784336
22high-density lipoprotein particle remodeling (GO:0034375)5.22300109
23alpha-linolenic acid metabolic process (GO:0036109)5.18808531
24aromatic amino acid family metabolic process (GO:0009072)5.15172983
25regulation of fibrinolysis (GO:0051917)5.12889176
26regulation of protein activation cascade (GO:2000257)5.11827701
27lysine metabolic process (GO:0006553)5.10083264
28lysine catabolic process (GO:0006554)5.10083264
29complement activation, alternative pathway (GO:0006957)5.09796727
30peptidyl-glutamic acid carboxylation (GO:0017187)5.07883040
31protein carboxylation (GO:0018214)5.07883040
32bile acid metabolic process (GO:0008206)5.03214911
33amino-acid betaine metabolic process (GO:0006577)4.93506016
34alpha-amino acid catabolic process (GO:1901606)4.91784601
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81388520
36regulation of complement activation (GO:0030449)4.79562685
37tyrosine metabolic process (GO:0006570)4.79020553
38* serine family amino acid metabolic process (GO:0009069)4.77431405
39* homocysteine metabolic process (GO:0050667)4.76192920
40regulation of cholesterol esterification (GO:0010872)4.57503138
41regulation of triglyceride catabolic process (GO:0010896)4.54299371
42reverse cholesterol transport (GO:0043691)4.51832979
43* cellular amino acid catabolic process (GO:0009063)4.51095553
44indolalkylamine metabolic process (GO:0006586)4.49731041
45imidazole-containing compound metabolic process (GO:0052803)4.48935467
46protein-lipid complex remodeling (GO:0034368)4.47647037
47macromolecular complex remodeling (GO:0034367)4.47647037
48plasma lipoprotein particle remodeling (GO:0034369)4.47647037
49acylglycerol homeostasis (GO:0055090)4.44782842
50triglyceride homeostasis (GO:0070328)4.44782842
51negative regulation of cholesterol transport (GO:0032375)4.44234514
52negative regulation of sterol transport (GO:0032372)4.44234514
53amine catabolic process (GO:0009310)4.42898303
54cellular biogenic amine catabolic process (GO:0042402)4.42898303
55* serine family amino acid biosynthetic process (GO:0009070)4.42325192
56cellular ketone body metabolic process (GO:0046950)4.37955300
57glutamate metabolic process (GO:0006536)4.37666645
58bile acid and bile salt transport (GO:0015721)4.35210690
59cellular glucuronidation (GO:0052695)4.34853605
60coenzyme catabolic process (GO:0009109)4.30022357
61cellular modified amino acid catabolic process (GO:0042219)4.26620769
62benzene-containing compound metabolic process (GO:0042537)4.18025572
63phospholipid efflux (GO:0033700)4.16764811
64ethanol oxidation (GO:0006069)4.15500878
65aldehyde catabolic process (GO:0046185)4.12266659
66arginine metabolic process (GO:0006525)4.09933007
67plasma lipoprotein particle clearance (GO:0034381)4.09589913
68drug catabolic process (GO:0042737)4.06825650
69dicarboxylic acid biosynthetic process (GO:0043650)4.00497851
70urate metabolic process (GO:0046415)3.90083863
71omega-hydroxylase P450 pathway (GO:0097267)3.90058321
72* carboxylic acid catabolic process (GO:0046395)3.88346040
73* organic acid catabolic process (GO:0016054)3.88346040
74regulation of bile acid biosynthetic process (GO:0070857)3.87706899
75cholesterol efflux (GO:0033344)3.87607484
76uronic acid metabolic process (GO:0006063)3.84873947
77glucuronate metabolic process (GO:0019585)3.84873947
78acetyl-CoA metabolic process (GO:0006084)3.83260899
79fibrinolysis (GO:0042730)3.79884439
80L-serine metabolic process (GO:0006563)3.78758541
81ketone body metabolic process (GO:1902224)3.78231968
82low-density lipoprotein particle remodeling (GO:0034374)3.78093968
83aspartate family amino acid catabolic process (GO:0009068)3.77468665
84plasma lipoprotein particle assembly (GO:0034377)3.74269052
85tetrahydrofolate metabolic process (GO:0046653)3.73018290
86short-chain fatty acid metabolic process (GO:0046459)3.71810242
872-oxoglutarate metabolic process (GO:0006103)3.68836224
88regulation of cholesterol homeostasis (GO:2000188)3.67439899
89S-adenosylmethionine metabolic process (GO:0046500)3.67264315
90cholesterol homeostasis (GO:0042632)3.66215405
91cofactor catabolic process (GO:0051187)3.62728463
92blood coagulation, intrinsic pathway (GO:0007597)3.61957018
93exogenous drug catabolic process (GO:0042738)3.61552297
94response to nitrosative stress (GO:0051409)3.61543425
95sterol homeostasis (GO:0055092)3.61105274
96positive regulation of lipoprotein lipase activity (GO:0051006)3.58913189
97positive regulation of triglyceride lipase activity (GO:0061365)3.58913189
98very-low-density lipoprotein particle assembly (GO:0034379)3.58715924
99complement activation, classical pathway (GO:0006958)3.57480013
100drug transmembrane transport (GO:0006855)3.55135072
101heme transport (GO:0015886)3.53132701
102pyridine nucleotide biosynthetic process (GO:0019363)3.52842524
103nicotinamide nucleotide biosynthetic process (GO:0019359)3.52842524
104folic acid-containing compound biosynthetic process (GO:0009396)3.40921891
105chromatin remodeling at centromere (GO:0031055)3.40773878
106water-soluble vitamin biosynthetic process (GO:0042364)3.40273506
107DNA double-strand break processing (GO:0000729)3.40202807
108CENP-A containing nucleosome assembly (GO:0034080)3.36597207
109DNA replication checkpoint (GO:0000076)3.31623519
110mitochondrial RNA metabolic process (GO:0000959)3.22091585
111purine nucleobase biosynthetic process (GO:0009113)3.20741481
112nucleobase biosynthetic process (GO:0046112)3.19365948
113amino acid salvage (GO:0043102)3.19047713
114L-methionine salvage (GO:0071267)3.19047713
115L-methionine biosynthetic process (GO:0071265)3.19047713
116oxidative demethylation (GO:0070989)3.09810589
117somatic hypermutation of immunoglobulin genes (GO:0016446)3.09664827
118somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09664827
119negative regulation of DNA-dependent DNA replication (GO:2000104)3.08787405
120epoxygenase P450 pathway (GO:0019373)3.06130090
121* sulfur amino acid biosynthetic process (GO:0000097)3.03842738
122IMP biosynthetic process (GO:0006188)3.00090620
123pseudouridine synthesis (GO:0001522)2.99811470
124proteasome assembly (GO:0043248)2.99139237
125pteridine-containing compound biosynthetic process (GO:0042559)2.96940812
126histone exchange (GO:0043486)2.94796579
127methionine metabolic process (GO:0006555)2.94414150
128replication fork processing (GO:0031297)2.92049638
129tRNA aminoacylation for protein translation (GO:0006418)2.91930156
130amino acid activation (GO:0043038)2.91353712
131tRNA aminoacylation (GO:0043039)2.91353712
132methionine biosynthetic process (GO:0009086)2.90124441
133folic acid-containing compound metabolic process (GO:0006760)2.90108392
134intra-S DNA damage checkpoint (GO:0031573)2.86837858
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85343090
136regulation of centriole replication (GO:0046599)2.82185003
137aspartate family amino acid biosynthetic process (GO:0009067)2.78756271
138rRNA methylation (GO:0031167)2.77807377
139aspartate family amino acid metabolic process (GO:0009066)2.76858650
140rRNA modification (GO:0000154)2.76543857
141protein K11-linked deubiquitination (GO:0035871)2.72405499
142mitochondrial respiratory chain complex I assembly (GO:0032981)2.72233972
143NADH dehydrogenase complex assembly (GO:0010257)2.72233972
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72233972
145RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71826940
146tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71826940
147pteridine-containing compound metabolic process (GO:0042558)2.70364745
148synapsis (GO:0007129)2.68436325
149DNA strand elongation involved in DNA replication (GO:0006271)2.68310852
150branched-chain amino acid catabolic process (GO:0009083)2.67177738
151tRNA metabolic process (GO:0006399)2.63596512
152drug metabolic process (GO:0017144)2.59688887
153nuclear pore organization (GO:0006999)2.58869687
154ribosome assembly (GO:0042255)2.58863793
155DNA catabolic process, exonucleolytic (GO:0000738)2.58387418
156mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.58029381
157regulation of nuclear cell cycle DNA replication (GO:0033262)2.57132017
158maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56304437
159mitochondrial respiratory chain complex assembly (GO:0033108)2.55949092
160establishment of protein localization to mitochondrial membrane (GO:0090151)2.53845540
161tRNA processing (GO:0008033)2.53766178
162DNA strand elongation (GO:0022616)2.51784516
163* alpha-amino acid biosynthetic process (GO:1901607)2.48068382
164regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48032272
165regulation of mitotic spindle checkpoint (GO:1903504)2.48032272
166protein complex biogenesis (GO:0070271)2.47984275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.18104852
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.07592983
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.85076763
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.21075615
5* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19830950
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.01859342
7E2F7_22180533_ChIP-Seq_HELA_Human4.94443527
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.70353049
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.24852120
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.76925214
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.52693871
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.33546626
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06048803
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71709117
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69922884
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52026742
17ELK1_19687146_ChIP-ChIP_HELA_Human2.47598876
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.45720020
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43002993
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.36276158
21ZNF274_21170338_ChIP-Seq_K562_Hela2.33384418
22* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.23912152
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14958036
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10593223
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09376199
26VDR_23849224_ChIP-Seq_CD4+_Human2.03105066
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7666157
28VDR_22108803_ChIP-Seq_LS180_Human1.98934724
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98171401
30FOXP3_21729870_ChIP-Seq_TREG_Human1.97794778
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95840246
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90586553
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88345805
34DCP1A_22483619_ChIP-Seq_HELA_Human1.86958394
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86623577
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77520146
37FUS_26573619_Chip-Seq_HEK293_Human1.77383345
38EWS_26573619_Chip-Seq_HEK293_Human1.70416964
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70151017
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67951913
41MYC_18940864_ChIP-ChIP_HL60_Human1.62255879
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62159331
43* TTF2_22483619_ChIP-Seq_HELA_Human1.61728922
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61433141
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60436736
46CLOCK_20551151_ChIP-Seq_293T_Human1.59409847
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57928357
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.55564728
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54672164
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52955930
51GBX2_23144817_ChIP-Seq_PC3_Human1.46761673
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.44927553
53HNF4A_19822575_ChIP-Seq_HepG2_Human1.42838127
54GABP_19822575_ChIP-Seq_HepG2_Human1.41331839
55IGF1R_20145208_ChIP-Seq_DFB_Human1.39210824
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.38144995
57* XRN2_22483619_ChIP-Seq_HELA_Human1.38120917
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37538853
59HTT_18923047_ChIP-ChIP_STHdh_Human1.34761476
60RXRA_24833708_ChIP-Seq_LIVER_Mouse1.29686285
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29098201
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27310986
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26918768
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25244640
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24753737
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23360203
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22830954
68TAF15_26573619_Chip-Seq_HEK293_Human1.22788442
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.22567778
70GATA1_22025678_ChIP-Seq_K562_Human1.19636374
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19023575
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.18678297
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16890819
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15136557
75ZNF263_19887448_ChIP-Seq_K562_Human1.13284356
76* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12835155
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11733981
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10454320
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10117348
80P300_19829295_ChIP-Seq_ESCs_Human1.09392394
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08945171
82* SOX2_16153702_ChIP-ChIP_HESCs_Human1.08710879
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08202458
84KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06830884
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04551075
86* PHF8_20622853_ChIP-Seq_HELA_Human1.03423000
87KDM5A_27292631_Chip-Seq_BREAST_Human1.03181395
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.02275067
89TP53_22573176_ChIP-Seq_HFKS_Human1.02087173
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01471704
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.01031514
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99961019
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99460953
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98980961
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98155307
96AR_21909140_ChIP-Seq_LNCAP_Human0.96527888
97SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95283089
98ER_23166858_ChIP-Seq_MCF-7_Human0.95045294
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94941018
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94250413
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93772014
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91816132
103GATA4_25053715_ChIP-Seq_YYC3_Human0.91353732
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91260329
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89940265
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89317293
107* RBPJ_21746931_ChIP-Seq_IB4_Human0.88557272
108* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87550981
109* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86837070
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.86057866
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.85487109
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84314670
113* GATA6_21074721_ChIP-Seq_CACO-2_Human0.84291526
114* ETV1_20927104_ChIP-Seq_GIST48_Human0.83461172
115* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82855688
116CBP_20019798_ChIP-Seq_JUKART_Human0.82801846
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82801846
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81222611
119* HNFA_21074721_ChIP-Seq_CACO-2_Human0.81022560
120AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80828455
121* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.80793388
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80354572
123KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80344177
124RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79908680
125* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.79343223
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76871300
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76670117
128TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75256585
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.73633782
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67682811
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66562438
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64956029
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.63452473
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.61908575
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.61892419
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.61391082
137PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.61272808
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58201918
139EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.57560461
140GATA6_25053715_ChIP-Seq_YYC3_Human0.56947907
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.56357087
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.55441137
143CEBPB_22108803_ChIP-Seq_LS180_Human0.55379371
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.55117489
145* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54408660
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.54066201
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53126738
148* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.52810993
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.51725452
150IRF1_19129219_ChIP-ChIP_H3396_Human0.51471705
151CREB1_15753290_ChIP-ChIP_HEK293T_Human0.50475289
152RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.50248112
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.50107842
154* NANOG_16518401_ChIP-PET_MESCs_Mouse0.49659018
155FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49222773
156TCF3_18692474_ChIP-Seq_MESCs_Mouse0.48381129
157AR_20517297_ChIP-Seq_VCAP_Human0.48070876
158PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47485302
159* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45451158
160NANOG_18692474_ChIP-Seq_MEFs_Mouse0.44684998
161MYC_19915707_ChIP-ChIP_AK7_Human0.44681413
162STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.43388190
163GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.43291968
164MYC_18358816_ChIP-ChIP_MESCs_Mouse0.43054631
165FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.42870233
166* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.42642332
167P53_21459846_ChIP-Seq_SAOS-2_Human0.42636196
168* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.41954155
169STAT1_17558387_ChIP-Seq_HELA_Human0.41668688
170FOXA1_25552417_ChIP-Seq_VCAP_Human0.41382583
171KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.41229691
172SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.40903909
173TAF2_19829295_ChIP-Seq_ESCs_Human0.40814100
174SRF_21415370_ChIP-Seq_HL-1_Mouse0.40470320
175SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.39639066
176CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38879740
177NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.38539211
178* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.37964052
179MYC_18555785_ChIP-Seq_MESCs_Mouse0.37960318
180CBP_21632823_ChIP-Seq_H3396_Human0.37460680
181GATA3_24758297_ChIP-Seq_MCF-7_Human0.37201827
182Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.36775290
183SOX17_20123909_ChIP-Seq_XEN_Mouse0.36415683
184* SPI1_26923725_Chip-Seq_HPCs_Mouse0.36336696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.08574239
2MP0005360_urolithiasis7.82914783
3MP0005085_abnormal_gallbladder_physiolo6.37907049
4MP0005365_abnormal_bile_salt6.14965629
5MP0008875_abnormal_xenobiotic_pharmacok5.02005248
6MP0003806_abnormal_nucleotide_metabolis4.72011098
7MP0003252_abnormal_bile_duct3.80658151
8MP0010329_abnormal_lipoprotein_level3.43778222
9MP0008058_abnormal_DNA_repair3.24420383
10MP0009840_abnormal_foam_cell3.20448958
11* MP0005332_abnormal_amino_acid3.00115421
12MP0010094_abnormal_chromosome_stability2.95667654
13MP0003195_calcinosis2.90354705
14MP0005083_abnormal_biliary_tract2.87538609
15MP0003693_abnormal_embryo_hatching2.86394240
16MP0001666_abnormal_nutrient_absorption2.65812216
17MP0004019_abnormal_vitamin_homeostasis2.43701270
18MP0004957_abnormal_blastocyst_morpholog2.32388102
19MP0003191_abnormal_cellular_cholesterol2.13155966
20MP0000609_abnormal_liver_physiology2.12549790
21MP0002938_white_spotting2.08536199
22MP0004147_increased_porphyrin_level2.06912804
23MP0002138_abnormal_hepatobiliary_system2.02380360
24MP0003111_abnormal_nucleus_morphology2.02289862
25MP0006292_abnormal_olfactory_placode1.97887570
26* MP0002118_abnormal_lipid_homeostasis1.97641245
27MP0003868_abnormal_feces_composition1.86523113
28MP0005551_abnormal_eye_electrophysiolog1.83066776
29* MP0005319_abnormal_enzyme/_coenzyme1.81488963
30MP0008877_abnormal_DNA_methylation1.76800891
31MP0008057_abnormal_DNA_replication1.76556875
32MP0003077_abnormal_cell_cycle1.68662880
33MP0003890_abnormal_embryonic-extraembry1.67577507
34MP0003136_yellow_coat_color1.65569222
35MP0005451_abnormal_body_composition1.64683556
36MP0008932_abnormal_embryonic_tissue1.58880236
37* MP0001764_abnormal_homeostasis1.57304327
38MP0009697_abnormal_copulation1.57136264
39MP0003186_abnormal_redox_activity1.55460548
40MP0005584_abnormal_enzyme/coenzyme_acti1.48859133
41MP0005253_abnormal_eye_physiology1.42276050
42MP0002102_abnormal_ear_morphology1.40761457
43MP0000647_abnormal_sebaceous_gland1.39137670
44* MP0009643_abnormal_urine_homeostasis1.38180553
45MP0002736_abnormal_nociception_after1.33324485
46MP0008995_early_reproductive_senescence1.32424213
47MP0004133_heterotaxia1.31449478
48MP0003705_abnormal_hypodermis_morpholog1.31169690
49MP0003011_delayed_dark_adaptation1.30571771
50MP0005187_abnormal_penis_morphology1.29065472
51MP0003786_premature_aging1.28696081
52MP0006072_abnormal_retinal_apoptosis1.27600801
53MP0003567_abnormal_fetal_cardiomyocyte1.22373190
54MP0002234_abnormal_pharynx_morphology1.22349814
55* MP0000598_abnormal_liver_morphology1.20009997
56MP0000372_irregular_coat_pigmentation1.18335576
57MP0001929_abnormal_gametogenesis1.17557948
58MP0003656_abnormal_erythrocyte_physiolo1.14802397
59MP0002210_abnormal_sex_determination1.14599465
60MP0003937_abnormal_limbs/digits/tail_de1.12457673
61MP0001293_anophthalmia1.10748392
62MP0008789_abnormal_olfactory_epithelium1.09844036
63MP0005647_abnormal_sex_gland1.09244295
64MP0008007_abnormal_cellular_replicative1.05568152
65MP0005636_abnormal_mineral_homeostasis1.00481507
66MP0003698_abnormal_male_reproductive0.98936055
67MP0003718_maternal_effect0.98116399
68MP0000653_abnormal_sex_gland0.98091791
69MP0002254_reproductive_system_inflammat0.97482032
70MP0000631_abnormal_neuroendocrine_gland0.95432483
71MP0001145_abnormal_male_reproductive0.94797413
72MP0006036_abnormal_mitochondrial_physio0.93006103
73MP0005645_abnormal_hypothalamus_physiol0.91880874
74MP0009764_decreased_sensitivity_to0.90893775
75MP0002160_abnormal_reproductive_system0.90174487
76MP0002697_abnormal_eye_size0.89389899
77MP0001529_abnormal_vocalization0.89282884
78* MP0009763_increased_sensitivity_to0.88618302
79MP0005408_hypopigmentation0.88276586
80MP0001661_extended_life_span0.86568527
81MP0005646_abnormal_pituitary_gland0.86372992
82MP0005670_abnormal_white_adipose0.85636078
83MP0000604_amyloidosis0.84783244
84MP0003941_abnormal_skin_development0.82804678
85* MP0009642_abnormal_blood_homeostasis0.82366542
86MP0001756_abnormal_urination0.81638084
87MP0001697_abnormal_embryo_size0.81616760
88MP0005220_abnormal_exocrine_pancreas0.81538049
89MP0001984_abnormal_olfaction0.81312248
90MP0001324_abnormal_eye_pigmentation0.80927009
91MP0002090_abnormal_vision0.80521551
92MP0001286_abnormal_eye_development0.80252952
93MP0005394_taste/olfaction_phenotype0.79910462
94MP0005499_abnormal_olfactory_system0.79910462
95MP0005391_vision/eye_phenotype0.79688758
96* MP0005376_homeostasis/metabolism_phenot0.78786375
97MP0005266_abnormal_metabolism0.78564240
98MP0005410_abnormal_fertilization0.78133116
99* MP0008469_abnormal_protein_level0.77656810
100MP0009053_abnormal_anal_canal0.77443211
101MP0001968_abnormal_touch/_nociception0.77430481
102MP0005084_abnormal_gallbladder_morpholo0.77150271
103MP0009765_abnormal_xenobiotic_induced0.76826364
104MP0001188_hyperpigmentation0.76099483
105MP0004233_abnormal_muscle_weight0.75895595
106MP0002084_abnormal_developmental_patter0.72806191
107MP0001730_embryonic_growth_arrest0.71942415
108MP0005389_reproductive_system_phenotype0.71825267
109MP0005395_other_phenotype0.69850523
110MP0002078_abnormal_glucose_homeostasis0.69384678
111MP0000516_abnormal_urinary_system0.68992142
112MP0005367_renal/urinary_system_phenotyp0.68992142
113MP0001119_abnormal_female_reproductive0.68701886
114MP0002876_abnormal_thyroid_physiology0.68612962
115MP0010368_abnormal_lymphatic_system0.68480456
116MP0006035_abnormal_mitochondrial_morpho0.68141139
117MP0001485_abnormal_pinna_reflex0.67755197
118MP0005380_embryogenesis_phenotype0.67125157
119MP0001672_abnormal_embryogenesis/_devel0.67125157
120MP0003119_abnormal_digestive_system0.67056576
121MP0002233_abnormal_nose_morphology0.65967125
122MP0001919_abnormal_reproductive_system0.65724033
123MP0005195_abnormal_posterior_eye0.65107717
124MP0002971_abnormal_brown_adipose0.61325937
125MP0002136_abnormal_kidney_physiology0.61156418
126MP0005334_abnormal_fat_pad0.59341571
127MP0005535_abnormal_body_temperature0.54690804
128MP0009672_abnormal_birth_weight0.52226385
129MP0000639_abnormal_adrenal_gland0.47873282
130MP0004130_abnormal_muscle_cell0.47142568
131MP0004264_abnormal_extraembryonic_tissu0.45997749
132MP0003690_abnormal_glial_cell0.45834257
133MP0003638_abnormal_response/metabolism_0.44881486
134MP0004043_abnormal_pH_regulation0.44136272
135MP0002796_impaired_skin_barrier0.43828259
136MP0005448_abnormal_energy_balance0.43760596
137MP0003329_amyloid_beta_deposits0.42913776
138MP0004782_abnormal_surfactant_physiolog0.42036390
139MP0005666_abnormal_adipose_tissue0.42012943
140* MP0008873_increased_physiological_sensi0.37877134
141MP0003953_abnormal_hormone_level0.37490549
142MP0002928_abnormal_bile_duct0.36737286
143MP0008872_abnormal_physiological_respon0.36138434
144MP0005248_abnormal_Harderian_gland0.35543288
145MP0002168_other_aberrant_phenotype0.32326631
146MP0009115_abnormal_fat_cell0.30697199
147MP0000579_abnormal_nail_morphology0.29375031
148MP0002970_abnormal_white_adipose0.28551606
149MP0001243_abnormal_dermal_layer0.28110168
150MP0002135_abnormal_kidney_morphology0.27932225
151MP0005464_abnormal_platelet_physiology0.27872932
152MP0010234_abnormal_vibrissa_follicle0.27682147
153MP0002132_abnormal_respiratory_system0.27246500
154MP0003699_abnormal_female_reproductive0.27104023
155MP0005166_decreased_susceptibility_to0.26310470
156MP0001881_abnormal_mammary_gland0.25395262
157MP0005023_abnormal_wound_healing0.24878674
158MP0005058_abnormal_lysosome_morphology0.24758470
159MP0009384_cardiac_valve_regurgitation0.24514848
160MP0003453_abnormal_keratinocyte_physiol0.24171526
161MP0001853_heart_inflammation0.23741875
162MP0004381_abnormal_hair_follicle0.23647273
163MP0002060_abnormal_skin_morphology0.22587014
164MP0004883_abnormal_blood_vessel0.21321053
165MP0002822_catalepsy0.21056939
166MP0001765_abnormal_ion_homeostasis0.20789979
167MP0000249_abnormal_blood_vessel0.20767936
168MP0003436_decreased_susceptibility_to0.20542997

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.35084147
2Intrahepatic cholestasis (HP:0001406)7.25828991
3Deep venous thrombosis (HP:0002625)6.97630143
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.88123661
5Hypobetalipoproteinemia (HP:0003563)6.37467599
6Prolonged partial thromboplastin time (HP:0003645)6.11806786
7Xanthomatosis (HP:0000991)6.10004369
8Hyperglycinemia (HP:0002154)5.25860199
9Hyperlipoproteinemia (HP:0010980)5.25132091
10Complement deficiency (HP:0004431)5.04922716
11Hyperglycinuria (HP:0003108)4.89931513
12Hyperammonemia (HP:0001987)4.84172181
13Hypolipoproteinemia (HP:0010981)4.72130856
14Abnormality of glycine metabolism (HP:0010895)4.69272987
15Abnormality of serine family amino acid metabolism (HP:0010894)4.69272987
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.56256152
17Abnormality of methionine metabolism (HP:0010901)4.54736931
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.53619883
19Joint hemorrhage (HP:0005261)4.40487967
20Epidermoid cyst (HP:0200040)4.34675589
21* Abnormality of sulfur amino acid metabolism (HP:0004339)4.33792236
22Abnormality of pyrimidine metabolism (HP:0004353)4.31742894
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.27273560
24Ketosis (HP:0001946)4.25545651
25Fat malabsorption (HP:0002630)4.15058102
26Abnormality of the common coagulation pathway (HP:0010990)4.10430381
27Hypoalphalipoproteinemia (HP:0003233)4.02621065
28Hypoglycemic coma (HP:0001325)3.73806648
29Abnormality of complement system (HP:0005339)3.67021710
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.62892862
31Abnormality of alanine metabolism (HP:0010916)3.62892862
32Hyperalaninemia (HP:0003348)3.62892862
33Abnormality of serum amino acid levels (HP:0003112)3.62797460
34Abnormality of the intrinsic pathway (HP:0010989)3.58539226
35Conjugated hyperbilirubinemia (HP:0002908)3.51215544
36Abnormality of fatty-acid metabolism (HP:0004359)3.50861361
37Abnormality of nucleobase metabolism (HP:0010932)3.44312387
38Hypercholesterolemia (HP:0003124)3.39482888
39Delayed CNS myelination (HP:0002188)3.30250660
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26234786
41Gout (HP:0001997)3.20700168
42Steatorrhea (HP:0002570)3.17417278
43Hyperbilirubinemia (HP:0002904)3.17411295
44Birth length less than 3rd percentile (HP:0003561)3.08270379
45Acute encephalopathy (HP:0006846)3.02461256
46Increased serum pyruvate (HP:0003542)3.02166348
47Abnormality of purine metabolism (HP:0004352)3.00597133
48Ketoacidosis (HP:0001993)2.99348264
49Lethargy (HP:0001254)2.96072846
50Hepatocellular carcinoma (HP:0001402)2.95018959
51Hypochromic microcytic anemia (HP:0004840)2.86827172
52Metabolic acidosis (HP:0001942)2.85845019
53Abnormality of glycolysis (HP:0004366)2.83844638
54Spastic diplegia (HP:0001264)2.81626410
55Myocardial infarction (HP:0001658)2.78218234
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77866152
57Dicarboxylic aciduria (HP:0003215)2.77866152
58Spontaneous abortion (HP:0005268)2.77637265
59Pancreatic cysts (HP:0001737)2.73275293
60Acute necrotizing encephalopathy (HP:0006965)2.72933616
61Abnormality of the labia minora (HP:0012880)2.71683458
62Vascular calcification (HP:0004934)2.68100163
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66712990
64Skin nodule (HP:0200036)2.62858016
65Chromsome breakage (HP:0040012)2.61533860
66Cerebral edema (HP:0002181)2.58258612
67Homocystinuria (HP:0002156)2.57383854
68Abnormality of homocysteine metabolism (HP:0010919)2.57383854
69Irritability (HP:0000737)2.56788933
70Pancreatic fibrosis (HP:0100732)2.54630203
71Increased CSF lactate (HP:0002490)2.52398956
72Malnutrition (HP:0004395)2.50170779
73Abnormal mitochondria in muscle tissue (HP:0008316)2.48359112
74Increased serum lactate (HP:0002151)2.48302015
75Systemic lupus erythematosus (HP:0002725)2.42955610
76True hermaphroditism (HP:0010459)2.42706166
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.41623453
78Chronic hepatic failure (HP:0100626)2.39307594
79Cardiovascular calcification (HP:0011915)2.36020083
80Neonatal onset (HP:0003623)2.35776469
81Meckel diverticulum (HP:0002245)2.35160257
82Acanthocytosis (HP:0001927)2.35092369
83Methylmalonic acidemia (HP:0002912)2.28759488
84Abnormality of the ileum (HP:0001549)2.26334068
85Mitochondrial inheritance (HP:0001427)2.25353846
86Reduced antithrombin III activity (HP:0001976)2.23799489
87Abnormality of midbrain morphology (HP:0002418)2.23793696
88Molar tooth sign on MRI (HP:0002419)2.23793696
89Increased purine levels (HP:0004368)2.22995798
90Hyperuricemia (HP:0002149)2.22995798
91Generalized aminoaciduria (HP:0002909)2.21828205
92Progressive macrocephaly (HP:0004481)2.19979129
93Abnormal biliary tract physiology (HP:0012439)2.19638628
94Bile duct proliferation (HP:0001408)2.19638628
95Hypoglycemic seizures (HP:0002173)2.19438777
96Alkalosis (HP:0001948)2.19128009
97Abnormal gallbladder morphology (HP:0012437)2.18519142
98Abnormal cartilage morphology (HP:0002763)2.18489322
99Glomerulonephritis (HP:0000099)2.18303431
100Vomiting (HP:0002013)2.18060923
101Abnormality of the pons (HP:0007361)2.16675244
102Abnormality of chromosome stability (HP:0003220)2.16658378
103Cerebellar dysplasia (HP:0007033)2.16349233
104Proximal tubulopathy (HP:0000114)2.15709687
105Esophageal varix (HP:0002040)2.14154856
106Hepatocellular necrosis (HP:0001404)2.13333468
107Cholelithiasis (HP:0001081)2.13302194
108Pancreatitis (HP:0001733)2.13234491
109Enlarged kidneys (HP:0000105)2.11200107
110Mitral stenosis (HP:0001718)2.10572330
111Lactic acidosis (HP:0003128)2.08498278
112Hepatic necrosis (HP:0002605)2.07212704
113Sensorimotor neuropathy (HP:0007141)2.06151119
114Brushfield spots (HP:0001088)2.04488786
115Hypoplasia of the pons (HP:0012110)2.03833513
116Rickets (HP:0002748)2.03535303
117Opisthotonus (HP:0002179)2.02239692
118Sloping forehead (HP:0000340)1.98470604
119Lipid accumulation in hepatocytes (HP:0006561)1.97150761
120Abnormal gallbladder physiology (HP:0012438)1.97146571
121Cholecystitis (HP:0001082)1.97146571
122Hydroxyprolinuria (HP:0003080)1.97049404
123Abnormality of proline metabolism (HP:0010907)1.97049404
124Recurrent gram-negative bacterial infections (HP:0005420)1.97004205
125Late onset (HP:0003584)1.95220126
126Abnormality of the preputium (HP:0100587)1.95065473
127Abnormal enzyme/coenzyme activity (HP:0012379)1.93886924
128Colon cancer (HP:0003003)1.90278643
129Increased hepatocellular lipid droplets (HP:0006565)1.90016870
130Thrombophlebitis (HP:0004418)1.89746986
131Abnormal lung lobation (HP:0002101)1.89031725
132Nephronophthisis (HP:0000090)1.88393666
133Abnormality of vitamin metabolism (HP:0100508)1.88262255
134Methylmalonic aciduria (HP:0012120)1.86680571
135Menorrhagia (HP:0000132)1.85321551
136Abnormality of transition element cation homeostasis (HP:0011030)1.84586134
137Nausea (HP:0002018)1.84069230
138Abnormal number of erythroid precursors (HP:0012131)1.83952318
139Poikilocytosis (HP:0004447)1.83381756
140Renal cortical cysts (HP:0000803)1.82623406
141CNS demyelination (HP:0007305)1.82582053
142Abnormality of urine glucose concentration (HP:0011016)1.82040130
143Glycosuria (HP:0003076)1.82040130
144Abnormality of iron homeostasis (HP:0011031)1.82014117
145Type I transferrin isoform profile (HP:0003642)1.81092087
146Hyperglycemia (HP:0003074)1.80953487
147Duodenal stenosis (HP:0100867)1.80863089
148Small intestinal stenosis (HP:0012848)1.80863089
149Hyperinsulinemic hypoglycemia (HP:0000825)1.80289758
150Gingival bleeding (HP:0000225)1.79717679
151Megaloblastic anemia (HP:0001889)1.79541971
152Abnormality of the gallbladder (HP:0005264)1.78057992
153Abnormality of the duodenum (HP:0002246)1.77671795
154Horseshoe kidney (HP:0000085)1.77473325
155Medial flaring of the eyebrow (HP:0010747)1.76599890
156Abnormality of the renal cortex (HP:0011035)1.75003074
157Abnormality of the carotid arteries (HP:0005344)1.72409033
158Abolished electroretinogram (ERG) (HP:0000550)1.69911748
159Intestinal atresia (HP:0011100)1.67830402
160Pendular nystagmus (HP:0012043)1.66006003
1613-Methylglutaconic aciduria (HP:0003535)1.65995066
162Abnormality of cells of the erythroid lineage (HP:0012130)1.63486312
163Fair hair (HP:0002286)1.60163110
164Reticulocytopenia (HP:0001896)1.59581628
165Aplasia/Hypoplasia of the tongue (HP:0010295)1.58761252
166Optic disc pallor (HP:0000543)1.57357418
167Microvesicular hepatic steatosis (HP:0001414)1.57230926
168Glioma (HP:0009733)1.56956440
169Sclerocornea (HP:0000647)1.56744869
170Bifid tongue (HP:0010297)1.56493135
171Cortical dysplasia (HP:0002539)1.56164162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.79274191
2FGFR44.10902683
3SIK13.80155689
4ERN13.56764819
5ZAK3.32174583
6ERBB43.00003483
7MST42.62464063
8CDC72.44810664
9BRSK22.43826130
10LATS12.32724707
11TAOK32.30343394
12SRPK12.29551890
13PLK42.28630957
14STK38L2.24830048
15INSRR2.21767288
16BMPR1B2.12691832
17MST1R2.10101969
18VRK22.09626597
19PLK31.99503002
20NUAK11.96625089
21TSSK61.95977520
22TNIK1.94600748
23PKN21.88582678
24MAPK111.87765779
25MKNK11.81808716
26VRK11.81258903
27FLT31.76502162
28PNCK1.75534969
29MAP2K41.72844595
30MKNK21.70406268
31WNK41.67319408
32NEK11.63844691
33TRIM281.59827911
34MAP4K21.56748802
35ABL21.55203276
36OXSR11.49392957
37STK391.46793945
38PIK3CG1.46228294
39NME11.43598975
40EPHA21.36952559
41TRIB31.36545411
42TYK21.30813835
43FRK1.28925985
44WEE11.28345172
45PDK31.27624787
46PDK41.27624787
47NEK91.27566345
48AKT31.25667127
49MAP3K31.25459107
50PINK11.23335318
51PLK21.20321288
52EIF2AK11.19698887
53CHEK21.19270636
54PTK61.18012462
55CASK1.17139447
56MET1.13492404
57WNK31.12687004
58LATS21.12669505
59TAF11.08219547
60BCR1.08215365
61KDR1.05673964
62CDK61.04786151
63TLK11.04026495
64GRK61.03102752
65ATR1.01819814
66DYRK20.98023908
67PRKAA20.97989638
68MAP2K30.97308001
69FGFR20.96014074
70ERBB20.92690111
71CDK40.91633382
72PDK20.91491947
73JAK20.89384699
74TTK0.88098763
75CCNB10.86308252
76ERBB30.86135590
77BRSK10.84895329
78DYRK30.84757713
79IRAK30.82000246
80MAPKAPK50.81690094
81PRKAA10.81170834
82MAPK40.79152967
83DAPK20.76976039
84MAP3K110.76393729
85MAP3K100.75965612
86PRKCZ0.75942500
87TGFBR10.75654141
88MAP3K70.74446327
89GSK3A0.73434403
90AURKB0.72992859
91EIF2AK20.72584610
92ADRBK20.71568967
93BUB10.71373894
94PBK0.70941237
95MAP3K90.69543353
96NME20.66541542
97ATM0.64872025
98PRKACG0.64298654
99STK30.64028211
100TAOK20.62974981
101MTOR0.61482857
102DYRK1B0.61453123
103PASK0.60469050
104CSNK1G10.60435634
105NTRK30.59601859
106RPS6KA50.59175337
107ACVR1B0.58702600
108YES10.58609515
109MAP2K60.58498985
110CHEK10.57217075
111CSNK1A1L0.56983301
112CDK90.56414452
113PRKCI0.53714358
114RPS6KA40.53380373
115MAP3K50.53122399
116MAP3K40.52827759
117CAMK2G0.52144363
118MAPK120.51627627
119PRKCE0.50666938
120BRD40.50155851
121MAP3K80.50141127
122FER0.48374212
123RPS6KB20.48130171
124SGK30.47145527
125PTK20.46545531
126TIE10.46476982
127CDK70.46132129
128MAPK130.45878015
129CSNK1A10.45640737
130CDK30.44549965
131STK160.44450003
132MAP2K20.43386255
133MAP3K140.42297773
134PHKG10.41302767
135PHKG20.41302767
136CDK10.40798545
137JAK10.40748893
138CSNK1E0.38713564
139TBK10.38698396
140MAPK70.38625764
141MAPK150.37105296
142CDK80.35792248
143NEK20.35286863
144NEK60.35172432
145GRK10.34607181
146SGK20.34506744
147CSK0.34301314
148MAP2K10.33980477
149PRKCG0.33583767
150PDPK10.33340562
151CSNK1G30.33127097
152PLK10.33051881
153EIF2AK30.33043530
154CDK20.32875707
155PIM10.32215329
156PRKDC0.31403691
157STK380.29600691
158TESK20.27803326
159CSNK2A20.26509315
160IGF1R0.25820056
161CSNK2A10.25550756
162AURKA0.24787083
163AKT20.24486768
164CSF1R0.22319481
165CSNK1G20.22264587
166MAP3K60.22251517

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.27880289
2Nitrogen metabolism_Homo sapiens_hsa009103.58601974
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35061350
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32262113
5Arginine biosynthesis_Homo sapiens_hsa002203.09526333
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82798510
7* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.71185740
8Tryptophan metabolism_Homo sapiens_hsa003802.64108490
9Complement and coagulation cascades_Homo sapiens_hsa046102.48447382
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45015793
11Fatty acid degradation_Homo sapiens_hsa000712.40309990
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38547434
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28072697
14Butanoate metabolism_Homo sapiens_hsa006502.14876931
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07261266
16Peroxisome_Homo sapiens_hsa041462.03383181
17Mismatch repair_Homo sapiens_hsa034302.02528856
18Homologous recombination_Homo sapiens_hsa034401.97053948
19Propanoate metabolism_Homo sapiens_hsa006401.95626723
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91791315
21Chemical carcinogenesis_Homo sapiens_hsa052041.90395040
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.88083441
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.86776365
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.86294581
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84055710
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.83286627
27Histidine metabolism_Homo sapiens_hsa003401.81247500
28DNA replication_Homo sapiens_hsa030301.73733171
29PPAR signaling pathway_Homo sapiens_hsa033201.73029104
30beta-Alanine metabolism_Homo sapiens_hsa004101.73028557
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72337975
32Protein export_Homo sapiens_hsa030601.68480839
33Fatty acid metabolism_Homo sapiens_hsa012121.68270829
34Retinol metabolism_Homo sapiens_hsa008301.67877613
35Caffeine metabolism_Homo sapiens_hsa002321.64997391
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57203777
37Non-homologous end-joining_Homo sapiens_hsa034501.54327708
38RNA polymerase_Homo sapiens_hsa030201.54251058
39Phenylalanine metabolism_Homo sapiens_hsa003601.53898255
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50713871
41Staphylococcus aureus infection_Homo sapiens_hsa051501.48833312
42Fanconi anemia pathway_Homo sapiens_hsa034601.46372206
43* Cysteine and methionine metabolism_Homo sapiens_hsa002701.46280736
44Basal transcription factors_Homo sapiens_hsa030221.46123154
45Folate biosynthesis_Homo sapiens_hsa007901.45811139
46Oxidative phosphorylation_Homo sapiens_hsa001901.42332120
47* Selenocompound metabolism_Homo sapiens_hsa004501.41487403
48Bile secretion_Homo sapiens_hsa049761.40991119
49* Biosynthesis of amino acids_Homo sapiens_hsa012301.40009055
50Vitamin B6 metabolism_Homo sapiens_hsa007501.39046341
51Tyrosine metabolism_Homo sapiens_hsa003501.38994129
52Pyruvate metabolism_Homo sapiens_hsa006201.38130520
53RNA transport_Homo sapiens_hsa030131.33529639
54Sulfur metabolism_Homo sapiens_hsa009201.30538975
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.29369966
56Carbon metabolism_Homo sapiens_hsa012001.28911149
57RNA degradation_Homo sapiens_hsa030181.26993332
58Nucleotide excision repair_Homo sapiens_hsa034201.24389675
59Starch and sucrose metabolism_Homo sapiens_hsa005001.23292139
60Parkinsons disease_Homo sapiens_hsa050121.21659445
61One carbon pool by folate_Homo sapiens_hsa006701.17700100
62Fatty acid elongation_Homo sapiens_hsa000621.14858864
63Ribosome_Homo sapiens_hsa030101.14789734
64Steroid biosynthesis_Homo sapiens_hsa001001.14270287
65Fat digestion and absorption_Homo sapiens_hsa049751.13668945
66Base excision repair_Homo sapiens_hsa034101.13062638
67Arginine and proline metabolism_Homo sapiens_hsa003301.09190033
68Spliceosome_Homo sapiens_hsa030401.07834249
69Vitamin digestion and absorption_Homo sapiens_hsa049771.03326078
70ABC transporters_Homo sapiens_hsa020101.02344311
71Sulfur relay system_Homo sapiens_hsa041221.01754491
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99832193
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97124842
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.91203550
75Huntingtons disease_Homo sapiens_hsa050160.91078574
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90954657
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89986905
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86730780
79Glutathione metabolism_Homo sapiens_hsa004800.85019011
80Lysine degradation_Homo sapiens_hsa003100.80761995
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78335136
82Pentose phosphate pathway_Homo sapiens_hsa000300.74392801
83Cell cycle_Homo sapiens_hsa041100.70633289
84Glycerolipid metabolism_Homo sapiens_hsa005610.68278573
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63469279
86mRNA surveillance pathway_Homo sapiens_hsa030150.61458672
87Alzheimers disease_Homo sapiens_hsa050100.56070997
88* Metabolic pathways_Homo sapiens_hsa011000.52908915
89Phototransduction_Homo sapiens_hsa047440.51940333
90Fructose and mannose metabolism_Homo sapiens_hsa000510.43428833
91Fatty acid biosynthesis_Homo sapiens_hsa000610.43326192
92Ether lipid metabolism_Homo sapiens_hsa005650.42645058
93p53 signaling pathway_Homo sapiens_hsa041150.36499757
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34538300
95Galactose metabolism_Homo sapiens_hsa000520.30030590
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28089895
97Nicotine addiction_Homo sapiens_hsa050330.27766816
98Prion diseases_Homo sapiens_hsa050200.27514289
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23922797
100Linoleic acid metabolism_Homo sapiens_hsa005910.23523700
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.20970486
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16582582
103Insulin resistance_Homo sapiens_hsa049310.14520687
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.12199221
105Glucagon signaling pathway_Homo sapiens_hsa049220.02967262
106Regulation of autophagy_Homo sapiens_hsa041400.02701287
107Pyrimidine metabolism_Homo sapiens_hsa002400.02148160
108AMPK signaling pathway_Homo sapiens_hsa041520.00096794
109Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2340041
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2332442
111Hepatitis C_Homo sapiens_hsa05160-0.2212025
112Purine metabolism_Homo sapiens_hsa00230-0.2208716
113Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2189515
114Mineral absorption_Homo sapiens_hsa04978-0.2148245
115Proteasome_Homo sapiens_hsa03050-0.2119546
116Bladder cancer_Homo sapiens_hsa05219-0.2083681
117Protein digestion and absorption_Homo sapiens_hsa04974-0.1770750
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1688605
119Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1650593
120Insulin signaling pathway_Homo sapiens_hsa04910-0.1604521
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1544437
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0981031
123Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0911424
124Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0859106
125Renin-angiotensin system_Homo sapiens_hsa04614-0.0726223
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0148261

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