CTF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.65216893
2L-phenylalanine metabolic process (GO:0006558)5.65216893
3L-phenylalanine catabolic process (GO:0006559)5.52261379
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.52261379
5response to pheromone (GO:0019236)5.33917658
6sulfur amino acid catabolic process (GO:0000098)5.15269776
7cysteine metabolic process (GO:0006534)4.81874863
8behavioral response to nicotine (GO:0035095)4.70208971
9aromatic amino acid family catabolic process (GO:0009074)4.66679382
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.59750030
11glyoxylate metabolic process (GO:0046487)4.57560437
12alpha-linolenic acid metabolic process (GO:0036109)4.55877367
13homocysteine metabolic process (GO:0050667)4.40069024
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.32797124
15kynurenine metabolic process (GO:0070189)4.30027486
16lysine metabolic process (GO:0006553)4.28798333
17lysine catabolic process (GO:0006554)4.28798333
18valine metabolic process (GO:0006573)4.26166219
19axoneme assembly (GO:0035082)4.21966493
20tryptophan catabolic process (GO:0006569)4.09637377
21indole-containing compound catabolic process (GO:0042436)4.09637377
22indolalkylamine catabolic process (GO:0046218)4.09637377
23bile acid biosynthetic process (GO:0006699)4.00403655
24tryptophan metabolic process (GO:0006568)3.97647438
25serine family amino acid catabolic process (GO:0009071)3.92901619
26branched-chain amino acid catabolic process (GO:0009083)3.90989853
27ethanol oxidation (GO:0006069)3.89752693
28axonemal dynein complex assembly (GO:0070286)3.86830156
29amino-acid betaine metabolic process (GO:0006577)3.83890051
30peptidyl-glutamic acid carboxylation (GO:0017187)3.81705893
31protein carboxylation (GO:0018214)3.81705893
32fatty acid beta-oxidation (GO:0006635)3.79932032
33high-density lipoprotein particle remodeling (GO:0034375)3.79025928
34branched-chain amino acid metabolic process (GO:0009081)3.77329897
35cilium or flagellum-dependent cell motility (GO:0001539)3.74032293
36regulation of triglyceride catabolic process (GO:0010896)3.72427840
37aldehyde catabolic process (GO:0046185)3.70848409
38cornea development in camera-type eye (GO:0061303)3.68858230
39glucuronate metabolic process (GO:0019585)3.68021162
40uronic acid metabolic process (GO:0006063)3.68021162
412-oxoglutarate metabolic process (GO:0006103)3.66299136
42xenobiotic catabolic process (GO:0042178)3.65512675
43fatty acid oxidation (GO:0019395)3.62270657
44response to nitrosative stress (GO:0051409)3.61909329
45negative regulation of fibrinolysis (GO:0051918)3.60496923
46base-excision repair, AP site formation (GO:0006285)3.59088108
47glycine metabolic process (GO:0006544)3.58935551
48lipid oxidation (GO:0034440)3.56051628
49protein polyglutamylation (GO:0018095)3.54871002
50regulation of cholesterol esterification (GO:0010872)3.53368432
51cellular modified amino acid catabolic process (GO:0042219)3.51931104
52epithelial cilium movement (GO:0003351)3.51855023
53regulation of cilium movement (GO:0003352)3.50599782
54alpha-amino acid catabolic process (GO:1901606)3.50473229
55cellular amino acid catabolic process (GO:0009063)3.49100241
56complement activation, alternative pathway (GO:0006957)3.48154580
57serine family amino acid metabolic process (GO:0009069)3.48100408
58regulation of fibrinolysis (GO:0051917)3.47811327
59fatty acid catabolic process (GO:0009062)3.47435921
60serine family amino acid biosynthetic process (GO:0009070)3.46524049
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46437297
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.46233004
63short-chain fatty acid metabolic process (GO:0046459)3.46191571
64blood coagulation, intrinsic pathway (GO:0007597)3.44692418
65regulation of glucokinase activity (GO:0033131)3.43528513
66regulation of hexokinase activity (GO:1903299)3.43528513
67monocarboxylic acid catabolic process (GO:0072329)3.42050127
68negative regulation of sterol transport (GO:0032372)3.41546429
69negative regulation of cholesterol transport (GO:0032375)3.41546429
70regulation of cholesterol metabolic process (GO:0090181)3.39782101
71reverse cholesterol transport (GO:0043691)3.37760196
72platelet dense granule organization (GO:0060155)3.37607191
73regulation of protein activation cascade (GO:2000257)3.35535710
74carnitine metabolic process (GO:0009437)3.35274655
75cellular glucuronidation (GO:0052695)3.35235906
76bile acid metabolic process (GO:0008206)3.34118998
77carboxylic acid catabolic process (GO:0046395)3.33059795
78organic acid catabolic process (GO:0016054)3.33059795
79aromatic amino acid family metabolic process (GO:0009072)3.31989697
80cilium movement (GO:0003341)3.27956512
81coenzyme catabolic process (GO:0009109)3.26809440
82aspartate family amino acid catabolic process (GO:0009068)3.25607270
83regulation of cholesterol biosynthetic process (GO:0045540)3.24005689
84cell wall macromolecule catabolic process (GO:0016998)3.23993332
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22823356
86negative regulation of lipase activity (GO:0060192)3.22810115
87imidazole-containing compound metabolic process (GO:0052803)3.22009027
88ribosomal small subunit assembly (GO:0000028)3.20807695
89benzene-containing compound metabolic process (GO:0042537)3.20763379
90protein-lipid complex remodeling (GO:0034368)3.20594261
91macromolecular complex remodeling (GO:0034367)3.20594261
92plasma lipoprotein particle remodeling (GO:0034369)3.20594261
93intestinal cholesterol absorption (GO:0030299)3.19660027
94flavonoid metabolic process (GO:0009812)3.12692244
95urea metabolic process (GO:0019627)3.10764154
96urea cycle (GO:0000050)3.10764154
97regulation of plasminogen activation (GO:0010755)3.10293470
98ubiquinone biosynthetic process (GO:0006744)3.09472003
99actin-myosin filament sliding (GO:0033275)3.09429476
100muscle filament sliding (GO:0030049)3.09429476
101L-serine metabolic process (GO:0006563)3.08658825
102regulation of complement activation (GO:0030449)3.07067023
103cellular response to exogenous dsRNA (GO:0071360)3.07040020
104positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.06975799
105regulation of cholesterol homeostasis (GO:2000188)3.06226681
106DNA deamination (GO:0045006)3.06022629
107regulation of sequestering of triglyceride (GO:0010889)3.05905494
108fucose catabolic process (GO:0019317)3.05715493
109L-fucose metabolic process (GO:0042354)3.05715493
110L-fucose catabolic process (GO:0042355)3.05715493
111negative regulation of fatty acid biosynthetic process (GO:0045717)3.03179157
112positive regulation of lipid catabolic process (GO:0050996)3.02793434
113phospholipid efflux (GO:0033700)3.02296309
114triglyceride homeostasis (GO:0070328)3.02094312
115acylglycerol homeostasis (GO:0055090)3.02094312
116regulation of fatty acid beta-oxidation (GO:0031998)3.01748364
117viral transcription (GO:0019083)3.01496752
118translational termination (GO:0006415)3.00938208
119photoreceptor cell development (GO:0042461)3.00627798
120motile cilium assembly (GO:0044458)2.98908943
121positive regulation of histone deacetylation (GO:0031065)2.98757182
122nitrogen cycle metabolic process (GO:0071941)2.97799998
123plasma lipoprotein particle clearance (GO:0034381)2.97352962
124negative regulation of erythrocyte differentiation (GO:0045647)2.96336530
125arginine metabolic process (GO:0006525)2.95019627
126response to mercury ion (GO:0046689)2.94427912
127oxaloacetate metabolic process (GO:0006107)2.93871591
128antigen processing and presentation via MHC class Ib (GO:0002475)2.92458223
129ubiquinone metabolic process (GO:0006743)2.86121854
130detection of light stimulus involved in sensory perception (GO:0050962)2.82096883
131detection of light stimulus involved in visual perception (GO:0050908)2.82096883
132negative regulation of telomere maintenance (GO:0032205)2.80026810
133retinal cone cell development (GO:0046549)2.78135239
134arginine catabolic process (GO:0006527)2.78034250
135positive regulation of defense response to virus by host (GO:0002230)2.77597824
136cell wall macromolecule metabolic process (GO:0044036)2.77280987
137neuronal action potential (GO:0019228)2.76469539
138G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75463321
139regulation of skeletal muscle contraction (GO:0014819)2.75173608
140negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75092417
141cilium organization (GO:0044782)2.66397158
142water-soluble vitamin biosynthetic process (GO:0042364)2.65692160
143regulation of action potential (GO:0098900)2.65498509
144cilium morphogenesis (GO:0060271)2.65463851
145eye photoreceptor cell development (GO:0042462)2.64641522
146centriole replication (GO:0007099)2.64481398
147negative regulation of mast cell activation (GO:0033004)2.64184062
148detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63878942
149regulation of microtubule-based movement (GO:0060632)2.59928337
150actin-mediated cell contraction (GO:0070252)2.59527953
151regulation of type B pancreatic cell apoptotic process (GO:2000674)2.58384274
152cellular response to ATP (GO:0071318)2.58308118
153regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57032807
154alanine transport (GO:0032328)2.54474912
155fatty acid transmembrane transport (GO:1902001)2.53550683
156cilium assembly (GO:0042384)2.53391276
157lymphangiogenesis (GO:0001946)2.52973968
158auditory receptor cell stereocilium organization (GO:0060088)2.52748866
159metanephric mesenchyme development (GO:0072075)2.52666857
160positive regulation of cell fate commitment (GO:0010455)2.48433761
161negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.46352864
162inner ear receptor stereocilium organization (GO:0060122)2.45948397
163peptidyl-histidine modification (GO:0018202)2.44305948
164cellular ketone body metabolic process (GO:0046950)2.44264394
165intraciliary transport (GO:0042073)2.43701395
166photoreceptor cell maintenance (GO:0045494)2.42649125
167negative regulation of reactive oxygen species metabolic process (GO:2000378)2.40151108
168positive regulation of fatty acid oxidation (GO:0046321)2.39632495
169quinone biosynthetic process (GO:1901663)2.39210063
170negative regulation of systemic arterial blood pressure (GO:0003085)2.39047224
171pericardium development (GO:0060039)2.37765127
172N-acetylglucosamine metabolic process (GO:0006044)2.36107868
173cellular component assembly involved in morphogenesis (GO:0010927)2.36099039
174nephron tubule morphogenesis (GO:0072078)2.33799278
175nephron epithelium morphogenesis (GO:0072088)2.33799278
176carnitine transmembrane transport (GO:1902603)2.33378480
177kidney mesenchyme development (GO:0072074)2.32486558
178meiotic chromosome segregation (GO:0045132)2.31915066
179gamma-aminobutyric acid transport (GO:0015812)2.31738395
180exogenous drug catabolic process (GO:0042738)2.31699342
181regulation of hippo signaling (GO:0035330)2.28895559
182organic cation transport (GO:0015695)2.28068910
183reciprocal DNA recombination (GO:0035825)2.27632469
184reciprocal meiotic recombination (GO:0007131)2.27632469
185positive regulation of triglyceride biosynthetic process (GO:0010867)2.27618263
186ketone body metabolic process (GO:1902224)2.26781982
187regulation of triglyceride biosynthetic process (GO:0010866)2.26361339
188negative regulation of protein localization to cell surface (GO:2000009)2.26166524
189estrogen biosynthetic process (GO:0006703)2.25674874
190tachykinin receptor signaling pathway (GO:0007217)2.25673016
191tooth mineralization (GO:0034505)2.23746591
192adenosine metabolic process (GO:0046085)2.22456911
193action potential (GO:0001508)2.21547589
194regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.21474785
195carnitine shuttle (GO:0006853)2.20921922
196positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.20707695
197membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.17922894
198blood vessel maturation (GO:0001955)2.17832918
199myofibril assembly (GO:0030239)2.17152899
200C4-dicarboxylate transport (GO:0015740)2.16582721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.50211125
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.77938519
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.68784441
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.04347438
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.34570765
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.17703063
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.61938609
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.54291613
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.39572205
10VDR_22108803_ChIP-Seq_LS180_Human3.09930908
11ZNF274_21170338_ChIP-Seq_K562_Hela2.97247737
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.86450042
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.67026957
14EZH2_22144423_ChIP-Seq_EOC_Human2.63413562
15GBX2_23144817_ChIP-Seq_PC3_Human2.60485607
16IGF1R_20145208_ChIP-Seq_DFB_Human2.51847917
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39404200
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30219547
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.26140733
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.22685278
21ZNF263_19887448_ChIP-Seq_K562_Human2.22354523
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19640233
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16861800
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03168155
25SCL_19346495_ChIP-Seq_HPC-7_Human2.00910562
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00388330
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99536558
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94940230
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94451940
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91548176
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89386929
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88093859
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88063892
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.79940201
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78454128
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78059198
37CLOCK_20551151_ChIP-Seq_293T_Human1.70273213
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68216945
39ER_23166858_ChIP-Seq_MCF-7_Human1.65005262
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64687529
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62503923
42BCAT_22108803_ChIP-Seq_LS180_Human1.61120917
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56632703
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56157434
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.55003834
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.52244223
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48823872
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47809315
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45392327
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44711565
51P300_19829295_ChIP-Seq_ESCs_Human1.44063128
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.41028307
53DROSHA_22980978_ChIP-Seq_HELA_Human1.40461730
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40036207
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.38290684
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37145688
57EWS_26573619_Chip-Seq_HEK293_Human1.36133955
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35953068
59TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35934596
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32969944
61SMAD4_21799915_ChIP-Seq_A2780_Human1.32322980
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31414755
63STAT3_23295773_ChIP-Seq_U87_Human1.30837822
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30695545
65NANOG_20526341_ChIP-Seq_ESCs_Human1.29390656
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.29218954
67TCF4_23295773_ChIP-Seq_U87_Human1.28589898
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27266609
69NANOG_19829295_ChIP-Seq_ESCs_Human1.26587696
70SOX2_19829295_ChIP-Seq_ESCs_Human1.26587696
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24915169
72CBP_20019798_ChIP-Seq_JUKART_Human1.24130704
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24130704
74FUS_26573619_Chip-Seq_HEK293_Human1.22733893
75NCOR_22424771_ChIP-Seq_293T_Human1.22680240
76CJUN_26792858_Chip-Seq_BT549_Human1.21722775
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21535766
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20883963
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20108330
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.19832821
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18752570
82* TP53_22573176_ChIP-Seq_HFKS_Human1.17769385
83TCF4_22108803_ChIP-Seq_LS180_Human1.17352834
84HOXB7_26014856_ChIP-Seq_BT474_Human1.16884275
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16784504
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16661630
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16648116
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16643718
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16177568
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.15481047
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15354191
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15218943
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.15218943
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14491049
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14448074
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13967558
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13419216
98TP53_18474530_ChIP-ChIP_U2OS_Human1.13276511
99RACK7_27058665_Chip-Seq_MCF-7_Human1.13184834
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13095122
101LXR_22292898_ChIP-Seq_THP-1_Human1.12708596
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12060235
103CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12021433
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.12013262
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11823778
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.11432201
107MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11292473
108RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08958703
109E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08841864
110ERA_21632823_ChIP-Seq_H3396_Human1.07046092
111TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06906040
112MYC_19829295_ChIP-Seq_ESCs_Human1.06658579
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06226687
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.06119269
115AR_25329375_ChIP-Seq_VCAP_Human1.06097179
116ESR1_21235772_ChIP-Seq_MCF-7_Human1.05117480
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.04460496
118RXR_22108803_ChIP-Seq_LS180_Human1.04375594
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04162451
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.03664534
121* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03347601
122GATA1_22025678_ChIP-Seq_K562_Human1.02542225
123P53_21459846_ChIP-Seq_SAOS-2_Human1.02223437
124GATA4_25053715_ChIP-Seq_YYC3_Human1.01945959
125BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01065338
126RUNX2_22187159_ChIP-Seq_PCA_Human1.00647069
127* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00010171
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99888452
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99457725
130EZH2_27294783_Chip-Seq_ESCs_Mouse0.99288282
131IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99030138
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.98959249
133CDX2_22108803_ChIP-Seq_LS180_Human0.98590328
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97418482
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97168063
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97117293
137* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97020217
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.96964395
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96871480
140TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96814360
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96231878
142FOXH1_21741376_ChIP-Seq_EPCs_Human0.96221610
143TAF2_19829295_ChIP-Seq_ESCs_Human0.96198890
144FOXH1_21741376_ChIP-Seq_ESCs_Human0.95982421
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.95951721
146SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95574120
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95441044
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95335346
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95178889
150AHR_22903824_ChIP-Seq_MCF-7_Human0.94667441
151CDX2_20551321_ChIP-Seq_CACO-2_Human0.94523602
152RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92973341
153ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91333403
154SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90894970
155FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90752584
156P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90176556
157* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87840367
158SRF_21415370_ChIP-Seq_HL-1_Mouse0.87141174
159* ELK3_25401928_ChIP-Seq_HUVEC_Human0.85162509
160GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84584754
161SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84445710
162TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84032926
163ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83099896
164BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82132501
165* BCL6_27268052_Chip-Seq_Bcells_Human0.81855256
166CTCF_21964334_Chip-Seq_Bcells_Human0.81843129
167OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80921492
168SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79076355
169SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78716439
170RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77516881
171TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76317009
172GATA6_25053715_ChIP-Seq_YYC3_Human0.76042709
173PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74756633
174TET1_21451524_ChIP-Seq_MESCs_Mouse0.74212037
175SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73769166
176BP1_19119308_ChIP-ChIP_Hs578T_Human0.73607925
177GATA1_19941827_ChIP-Seq_MEL_Mouse0.73026307
178CTCF_21964334_ChIP-Seq_BJAB-B_Human0.71685587
179HNF4A_19822575_ChIP-Seq_HepG2_Human0.71354809
180LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71270570
181SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71048069
182NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70747808
183ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70715367
184* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70522187
185MYC_19030024_ChIP-ChIP_MESCs_Mouse0.69744560
186AR_20517297_ChIP-Seq_VCAP_Human0.69159997
187SOX2_20726797_ChIP-Seq_SW620_Human0.69076579
188CTCF_18555785_ChIP-Seq_MESCs_Mouse0.68814563
189MYB_21317192_ChIP-Seq_ERMYB_Mouse0.68749235
190KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.68619244
191FOXA2_19822575_ChIP-Seq_HepG2_Human0.68436619
192SPI1_20517297_ChIP-Seq_HL60_Human0.68300365
193EGR1_19374776_ChIP-ChIP_THP-1_Human0.67919493
194* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67466471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.01082390
2MP0005365_abnormal_bile_salt4.96374383
3MP0005085_abnormal_gallbladder_physiolo4.92573834
4MP0005360_urolithiasis4.73475793
5MP0008875_abnormal_xenobiotic_pharmacok3.66686022
6MP0003806_abnormal_nucleotide_metabolis3.59582527
7MP0010329_abnormal_lipoprotein_level2.86110067
8MP0003252_abnormal_bile_duct2.77953638
9MP0009840_abnormal_foam_cell2.69526491
10MP0005083_abnormal_biliary_tract2.51086444
11MP0001666_abnormal_nutrient_absorption2.40727821
12MP0000372_irregular_coat_pigmentation2.27627665
13MP0003186_abnormal_redox_activity2.22146258
14MP0005332_abnormal_amino_acid2.20893948
15MP0005503_abnormal_tendon_morphology2.11451439
16MP0008775_abnormal_heart_ventricle2.08111498
17MP0005551_abnormal_eye_electrophysiolog2.01897822
18MP0008789_abnormal_olfactory_epithelium1.98737271
19MP0003195_calcinosis1.97692308
20MP0005319_abnormal_enzyme/_coenzyme1.95956358
21MP0004084_abnormal_cardiac_muscle1.91010387
22MP0004885_abnormal_endolymph1.88099266
23MP0003136_yellow_coat_color1.87714049
24MP0002638_abnormal_pupillary_reflex1.85875999
25MP0005257_abnormal_intraocular_pressure1.82898243
26MP0003656_abnormal_erythrocyte_physiolo1.80567454
27MP0004036_abnormal_muscle_relaxation1.77198733
28MP0003011_delayed_dark_adaptation1.75905647
29MP0000609_abnormal_liver_physiology1.72944712
30MP0008438_abnormal_cutaneous_collagen1.72530232
31MP0008872_abnormal_physiological_respon1.68520258
32MP0005646_abnormal_pituitary_gland1.66377872
33MP0002118_abnormal_lipid_homeostasis1.64962621
34MP0009780_abnormal_chondrocyte_physiolo1.64578226
35MP0004130_abnormal_muscle_cell1.63285209
36MP0004215_abnormal_myocardial_fiber1.60418955
37MP0002653_abnormal_ependyma_morphology1.59401040
38MP0006292_abnormal_olfactory_placode1.56457270
39MP0003705_abnormal_hypodermis_morpholog1.53732987
40MP0002102_abnormal_ear_morphology1.52190551
41MP0002138_abnormal_hepatobiliary_system1.50692471
42MP0001968_abnormal_touch/_nociception1.50577789
43MP0002837_dystrophic_cardiac_calcinosis1.49691898
44MP0006036_abnormal_mitochondrial_physio1.48843372
45MP0004142_abnormal_muscle_tone1.48049109
46MP0002938_white_spotting1.43325364
47MP0005220_abnormal_exocrine_pancreas1.42961375
48MP0010386_abnormal_urinary_bladder1.42215598
49MP0002736_abnormal_nociception_after1.42120342
50MP0003950_abnormal_plasma_membrane1.38354965
51MP0005620_abnormal_muscle_contractility1.37903037
52MP0002735_abnormal_chemical_nociception1.37729024
53MP0005670_abnormal_white_adipose1.36523611
54MP0009643_abnormal_urine_homeostasis1.36324969
55MP0003191_abnormal_cellular_cholesterol1.35783912
56MP0004133_heterotaxia1.34676251
57MP0005584_abnormal_enzyme/coenzyme_acti1.33837630
58MP0000516_abnormal_urinary_system1.33822854
59MP0005367_renal/urinary_system_phenotyp1.33822854
60MP0003868_abnormal_feces_composition1.33740364
61MP0008877_abnormal_DNA_methylation1.32558645
62MP0009384_cardiac_valve_regurgitation1.32525057
63MP0001348_abnormal_lacrimal_gland1.30382880
64MP0002160_abnormal_reproductive_system1.27592851
65MP0004019_abnormal_vitamin_homeostasis1.24046600
66MP0009697_abnormal_copulation1.23991841
67MP0004484_altered_response_of1.23647554
68MP0000013_abnormal_adipose_tissue1.23206945
69MP0000598_abnormal_liver_morphology1.22550049
70MP0004147_increased_porphyrin_level1.21314866
71MP0005171_absent_coat_pigmentation1.21153001
72MP0005410_abnormal_fertilization1.20934805
73MP0005084_abnormal_gallbladder_morpholo1.19087943
74MP0002254_reproductive_system_inflammat1.18827058
75MP0005666_abnormal_adipose_tissue1.18034486
76MP0009046_muscle_twitch1.15798300
77MP0001542_abnormal_bone_strength1.15559700
78MP0000003_abnormal_adipose_tissue1.13413705
79MP0009764_decreased_sensitivity_to1.11432737
80MP0001502_abnormal_circadian_rhythm1.08690296
81MP0005253_abnormal_eye_physiology1.06983661
82MP0001958_emphysema1.05267280
83MP0008469_abnormal_protein_level1.05223222
84MP0006072_abnormal_retinal_apoptosis1.03089441
85MP0001501_abnormal_sleep_pattern1.01168899
86MP0000049_abnormal_middle_ear1.01033659
87MP0001545_abnormal_hematopoietic_system0.99932489
88MP0005397_hematopoietic_system_phenotyp0.99932489
89MP0002877_abnormal_melanocyte_morpholog0.99630507
90MP0002972_abnormal_cardiac_muscle0.99308649
91MP0002249_abnormal_larynx_morphology0.99044711
92MP0002108_abnormal_muscle_morphology0.98647520
93MP0000230_abnormal_systemic_arterial0.98459459
94MP0002272_abnormal_nervous_system0.97621006
95MP0005636_abnormal_mineral_homeostasis0.94567075
96MP0005647_abnormal_sex_gland0.94407092
97MP0005174_abnormal_tail_pigmentation0.94025763
98MP0004085_abnormal_heartbeat0.93257406
99MP0009745_abnormal_behavioral_response0.92556272
100MP0005389_reproductive_system_phenotype0.91754163
101MP0006276_abnormal_autonomic_nervous0.91739982
102MP0003638_abnormal_response/metabolism_0.90412222
103MP0003567_abnormal_fetal_cardiomyocyte0.90248366
104MP0005266_abnormal_metabolism0.90028543
105MP0000749_muscle_degeneration0.89863527
106MP0001984_abnormal_olfaction0.89634640
107MP0003137_abnormal_impulse_conducting0.89565010
108MP0002127_abnormal_cardiovascular_syste0.88550440
109MP0009763_increased_sensitivity_to0.87328253
110MP0009250_abnormal_appendicular_skeleto0.87327419
111MP0002106_abnormal_muscle_physiology0.86461913
112MP0001661_extended_life_span0.86204769
113MP0005330_cardiomyopathy0.85650555
114MP0000427_abnormal_hair_cycle0.85364630
115MP0005369_muscle_phenotype0.85167154
116MP0001986_abnormal_taste_sensitivity0.83991935
117MP0009642_abnormal_blood_homeostasis0.83934205
118MP0005464_abnormal_platelet_physiology0.82478779
119MP0003646_muscle_fatigue0.81014131
120MP0002295_abnormal_pulmonary_circulatio0.80961708
121MP0002078_abnormal_glucose_homeostasis0.79635320
122MP0005394_taste/olfaction_phenotype0.78830319
123MP0005499_abnormal_olfactory_system0.78830319
124MP0001485_abnormal_pinna_reflex0.78487422
125MP0000613_abnormal_salivary_gland0.78265846
126MP0000678_abnormal_parathyroid_gland0.78221749
127MP0000685_abnormal_immune_system0.77148908
128MP0001529_abnormal_vocalization0.76881654
129MP0010368_abnormal_lymphatic_system0.76257959
130MP0005195_abnormal_posterior_eye0.76135162
131MP0001970_abnormal_pain_threshold0.75483111
132MP0000747_muscle_weakness0.75117431
133MP0004043_abnormal_pH_regulation0.74406498
134MP0000343_altered_response_to0.74269649
135MP0005023_abnormal_wound_healing0.73766026
136MP0005508_abnormal_skeleton_morphology0.73525466
137MP0001270_distended_abdomen0.73486798
138MP0004782_abnormal_surfactant_physiolog0.73475457
139MP0003279_aneurysm0.72654900
140MP0000759_abnormal_skeletal_muscle0.72498984
141MP0001764_abnormal_homeostasis0.72439102
142MP0002796_impaired_skin_barrier0.71264082
143MP0002009_preneoplasia0.70832876
144MP0002269_muscular_atrophy0.70296072
145MP0001853_heart_inflammation0.69616799
146MP0006054_spinal_hemorrhage0.69006480
147MP0000751_myopathy0.69006169
148MP0002971_abnormal_brown_adipose0.68668023
149MP0009785_altered_susceptibility_to0.68650898
150MP0005334_abnormal_fat_pad0.68166498
151MP0000383_abnormal_hair_follicle0.66337292
152MP0010030_abnormal_orbit_morphology0.65156480
153MP0009379_abnormal_foot_pigmentation0.64750338
154MP0005375_adipose_tissue_phenotype0.64731529
155MP0010630_abnormal_cardiac_muscle0.64565658
156MP0002098_abnormal_vibrissa_morphology0.64490164
157MP0003943_abnormal_hepatobiliary_system0.64095122
158MP0003566_abnormal_cell_adhesion0.63508714
159MP0002060_abnormal_skin_morphology0.63336789
160MP0004808_abnormal_hematopoietic_stem0.62336091
161MP0004087_abnormal_muscle_fiber0.60467694
162MP0001944_abnormal_pancreas_morphology0.58913820
163MP0002876_abnormal_thyroid_physiology0.57566306
164MP0001879_abnormal_lymphatic_vessel0.57144697
165MP0005385_cardiovascular_system_phenoty0.56922333
166MP0001544_abnormal_cardiovascular_syste0.56922333
167MP0005275_abnormal_skin_tensile0.56779936
168MP0000750_abnormal_muscle_regeneration0.56563820
169MP0008004_abnormal_stomach_pH0.56365137
170MP0004145_abnormal_muscle_electrophysio0.56090554
171MP0009765_abnormal_xenobiotic_induced0.55547085
172MP0003221_abnormal_cardiomyocyte_apopto0.55410904
173MP0004185_abnormal_adipocyte_glucose0.55002279
174MP0003453_abnormal_keratinocyte_physiol0.54747864
175MP0006138_congestive_heart_failure0.54456632
176MP0005248_abnormal_Harderian_gland0.54345966
177MP0006035_abnormal_mitochondrial_morpho0.53770361

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.49811311
2Intrahepatic cholestasis (HP:0001406)5.03117231
3Deep venous thrombosis (HP:0002625)4.92743889
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.34555780
5Ketosis (HP:0001946)4.32693268
6Pancreatic fibrosis (HP:0100732)4.27502135
7Hypoglycemic coma (HP:0001325)4.11907585
8Xanthomatosis (HP:0000991)4.09453006
9True hermaphroditism (HP:0010459)4.04010693
10Congenital stationary night blindness (HP:0007642)4.01712070
11Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.00360406
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.99023157
13Absent/shortened dynein arms (HP:0200106)3.99023157
14Hypobetalipoproteinemia (HP:0003563)3.91147920
15Hyperlipoproteinemia (HP:0010980)3.87832905
16Hyperammonemia (HP:0001987)3.86023163
17Hyperglycinemia (HP:0002154)3.82118817
18Abnormality of fatty-acid metabolism (HP:0004359)3.81546125
19Pancreatic cysts (HP:0001737)3.74628985
20Molar tooth sign on MRI (HP:0002419)3.71841307
21Abnormality of midbrain morphology (HP:0002418)3.71841307
22Prolonged partial thromboplastin time (HP:0003645)3.70827053
23Abnormal respiratory motile cilium morphology (HP:0005938)3.69020995
24Abnormal respiratory epithelium morphology (HP:0012253)3.69020995
25Hyperglycinuria (HP:0003108)3.66678018
26Abnormality of glycine metabolism (HP:0010895)3.59579965
27Abnormality of serine family amino acid metabolism (HP:0010894)3.59579965
28Ketoacidosis (HP:0001993)3.59441680
29Keratoconus (HP:0000563)3.31313764
30Increased corneal curvature (HP:0100692)3.31313764
31Dicarboxylic aciduria (HP:0003215)3.29092582
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.29092582
33Abnormality of the common coagulation pathway (HP:0010990)3.26221034
34Abnormal rod and cone electroretinograms (HP:0008323)3.22104000
35Type 1 muscle fiber predominance (HP:0003803)3.19871738
36Type II lissencephaly (HP:0007260)3.18795635
37Fat malabsorption (HP:0002630)3.18671959
38Abnormal ciliary motility (HP:0012262)3.17011266
39Abnormality of the intrinsic pathway (HP:0010989)3.14171626
40Aplastic anemia (HP:0001915)3.13308791
41Nephronophthisis (HP:0000090)3.11620869
42Abnormality of sulfur amino acid metabolism (HP:0004339)3.09403395
43Abnormal respiratory motile cilium physiology (HP:0012261)3.02928552
44Hypolipoproteinemia (HP:0010981)3.01087918
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94298991
46Decreased central vision (HP:0007663)2.88976452
47Abnormality of serum amino acid levels (HP:0003112)2.86178863
48Medial flaring of the eyebrow (HP:0010747)2.83587024
49Hypoplasia of the fovea (HP:0007750)2.82603966
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.82603966
51Attenuation of retinal blood vessels (HP:0007843)2.81917172
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.80053916
53Spontaneous abortion (HP:0005268)2.78961670
54Abnormality of the renal cortex (HP:0011035)2.78644929
55Steatorrhea (HP:0002570)2.76321936
56Cerebral edema (HP:0002181)2.76281860
57Myoglobinuria (HP:0002913)2.75653982
58Generalized aminoaciduria (HP:0002909)2.75471742
59Hyperbilirubinemia (HP:0002904)2.74222420
60Hypoalphalipoproteinemia (HP:0003233)2.73547294
61Joint hemorrhage (HP:0005261)2.72893752
62Cystic liver disease (HP:0006706)2.70528742
63Abnormality of the renal medulla (HP:0100957)2.69107660
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68741957
65Complement deficiency (HP:0004431)2.68625303
66Abnormality of methionine metabolism (HP:0010901)2.67256279
67Sclerocornea (HP:0000647)2.66121741
68Metabolic acidosis (HP:0001942)2.64930712
69Rhinitis (HP:0012384)2.64732304
70Tubular atrophy (HP:0000092)2.63647643
71Lethargy (HP:0001254)2.63597046
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60823699
73Abnormality of glutamine family amino acid metabolism (HP:0010902)2.59069261
74Hypoglycemic seizures (HP:0002173)2.58559826
75Hepatic necrosis (HP:0002605)2.56223378
76Delayed CNS myelination (HP:0002188)2.55263217
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.54556370
78Spastic diplegia (HP:0001264)2.54463779
79Follicular hyperkeratosis (HP:0007502)2.49855193
80Increased muscle lipid content (HP:0009058)2.48956771
81Hypercholesterolemia (HP:0003124)2.48857206
82Muscle fiber inclusion bodies (HP:0100299)2.46093028
83Abnormality of macular pigmentation (HP:0008002)2.45976363
84Anencephaly (HP:0002323)2.38856077
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37482665
86Redundant skin (HP:0001582)2.33661739
87Hyperinsulinemic hypoglycemia (HP:0000825)2.32433604
88Abnormality of the heme biosynthetic pathway (HP:0010472)2.32162119
89Occipital encephalocele (HP:0002085)2.31069788
90Postaxial foot polydactyly (HP:0001830)2.30653745
91Calf muscle hypertrophy (HP:0008981)2.30104417
92Large for gestational age (HP:0001520)2.29894167
93Right ventricular cardiomyopathy (HP:0011663)2.29764796
94Congenital hepatic fibrosis (HP:0002612)2.29590020
95Gait imbalance (HP:0002141)2.25340791
96Abnormality of the fovea (HP:0000493)2.24450340
97Methylmalonic aciduria (HP:0012120)2.24123323
98Epidermoid cyst (HP:0200040)2.23580733
99Abolished electroretinogram (ERG) (HP:0000550)2.22278133
100Hip contracture (HP:0003273)2.22125478
101Gout (HP:0001997)2.21848180
102Pendular nystagmus (HP:0012043)2.20735502
103Distal arthrogryposis (HP:0005684)2.20321014
104Abnormality of purine metabolism (HP:0004352)2.20274220
105Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20043386
106Thrombocytosis (HP:0001894)2.19984003
107Brushfield spots (HP:0001088)2.18666934
108Nemaline bodies (HP:0003798)2.18381495
109Vascular calcification (HP:0004934)2.18364953
110Abnormality of nucleobase metabolism (HP:0010932)2.17244253
111Left ventricular hypertrophy (HP:0001712)2.16025138
112Increased intramyocellular lipid droplets (HP:0012240)2.15925047
113Increased serum ferritin (HP:0003281)2.14912940
114Congenital primary aphakia (HP:0007707)2.14821120
115Opisthotonus (HP:0002179)2.14109641
116Late onset (HP:0003584)2.13125654
117Esophageal varix (HP:0002040)2.11382207
118Abnormality of pyrimidine metabolism (HP:0004353)2.11184321
119Neonatal onset (HP:0003623)2.11013164
120Conjugated hyperbilirubinemia (HP:0002908)2.10895355
121Abnormality of the calf musculature (HP:0001430)2.07587647
122Abnormal hemoglobin (HP:0011902)2.07527754
123Nephrogenic diabetes insipidus (HP:0009806)2.06858952
124Polycythemia (HP:0001901)2.06103171
125Abnormality of iron homeostasis (HP:0011031)2.05589065
126Vomiting (HP:0002013)2.04028381
127Renal cortical cysts (HP:0000803)2.03820388
128Abnormality of cells of the erythroid lineage (HP:0012130)2.01953426
129Abnormality of DNA repair (HP:0003254)2.01161517
130Conical tooth (HP:0000698)2.00448961
131Aplasia/Hypoplasia of the spleen (HP:0010451)2.00161944
132Abnormal drinking behavior (HP:0030082)1.99428863
133Polydipsia (HP:0001959)1.99428863
134Hyperventilation (HP:0002883)1.98954989
135Pancreatitis (HP:0001733)1.98886841
136Esophageal neoplasm (HP:0100751)1.98705298
137Neoplasm of head and neck (HP:0012288)1.98705298
138Cardiovascular calcification (HP:0011915)1.98253739
139Furrowed tongue (HP:0000221)1.98114625
140Thrombophlebitis (HP:0004418)1.97629560
141Acute encephalopathy (HP:0006846)1.96958956
142Hepatocellular carcinoma (HP:0001402)1.96803198
143Bulbous nose (HP:0000414)1.96091312
144Exercise-induced myalgia (HP:0003738)1.95914532
145Abnormality of transition element cation homeostasis (HP:0011030)1.95703378
146Hepatocellular necrosis (HP:0001404)1.94750644
147Muscle hypertrophy of the lower extremities (HP:0008968)1.94549154
148Rhabdomyolysis (HP:0003201)1.94512402
149Ragged-red muscle fibers (HP:0003200)1.93653453
150Lactic acidosis (HP:0003128)1.92553998
151Menorrhagia (HP:0000132)1.92502186
152Lissencephaly (HP:0001339)1.91662842
153Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91494571
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91494571
155Abnormality of alanine metabolism (HP:0010916)1.91189629
156Hyperalaninemia (HP:0003348)1.91189629
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91189629
158Myocardial infarction (HP:0001658)1.91103220
159Asplenia (HP:0001746)1.90582210
160Polyuria (HP:0000103)1.90548053
161Postaxial hand polydactyly (HP:0001162)1.89612950
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88174107
163Hypertriglyceridemia (HP:0002155)1.88152458
164Soft skin (HP:0000977)1.87809875
165Abnormality of complement system (HP:0005339)1.87200733
166Gingival bleeding (HP:0000225)1.86629618
167Palpitations (HP:0001962)1.85521336
168Mesangial abnormality (HP:0001966)1.84548569
169Congenital sensorineural hearing impairment (HP:0008527)1.84202610
170Methylmalonic acidemia (HP:0002912)1.84104130
171Abnormal gallbladder morphology (HP:0012437)1.83310012
172Optic nerve hypoplasia (HP:0000609)1.82151756
173Broad-based gait (HP:0002136)1.82099038
174Absent phalangeal crease (HP:0006109)1.81062125
175Pachygyria (HP:0001302)1.77948691
176Genital tract atresia (HP:0001827)1.75000642
177Round ear (HP:0100830)1.69956317
178Chronic hepatic failure (HP:0100626)1.69949378
179Bony spicule pigmentary retinopathy (HP:0007737)1.69816566
180Atrial fibrillation (HP:0005110)1.66267801
181Ulnar deviation of the wrist (HP:0003049)1.66150556
182Absent speech (HP:0001344)1.66108355
183Progressive microcephaly (HP:0000253)1.65717737
184Nonprogressive disorder (HP:0003680)1.65467015
185Rib fusion (HP:0000902)1.65014022
186Vaginal atresia (HP:0000148)1.64782574
187Prolonged QT interval (HP:0001657)1.64592385
188Concave nail (HP:0001598)1.62582674
189Inability to walk (HP:0002540)1.62487421
190Male pseudohermaphroditism (HP:0000037)1.62241821
191Bell-shaped thorax (HP:0001591)1.60098886
192Limited hip movement (HP:0008800)1.59682767
193Chorioretinal atrophy (HP:0000533)1.59242641
194Lipoatrophy (HP:0100578)1.59045848
195Abnormal glycosylation (HP:0012345)1.57827009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.19819078
2MAP4K24.50036426
3PKN24.36819751
4FRK4.08481021
5NME23.72181179
6ERN13.52473377
7SIK13.39159565
8TRIB32.94943612
9GRK12.71014480
10CCNB12.63960059
11ADRBK22.61890081
12FLT32.40203991
13NEK22.33613138
14BMPR1B2.31912172
15MAP2K32.29682704
16NUAK12.26740081
17LRRK22.20472713
18INSRR2.20422553
19WNK42.19439092
20FGFR42.07100681
21PTK2B1.93320898
22MAPK131.91904668
23ZAK1.88846868
24TGFBR21.84953030
25RPS6KB21.79564352
26TTN1.78453335
27VRK21.71405692
28TGFBR11.67571066
29PTK61.66213678
30CDK191.63562255
31TLK11.62813855
32MAP3K31.57554095
33PDK21.51427988
34TXK1.47616294
35TBK11.46537649
36MST1R1.36073170
37WNK31.32771701
38LIMK11.27538858
39STK391.25678626
40MUSK1.24118151
41TAF11.23986930
42PIK3CG1.19887599
43TIE11.18446907
44EEF2K1.17908078
45MAPKAPK51.10281969
46STK161.06793517
47TYK21.05917875
48NTRK11.04699168
49MARK11.03985388
50NEK91.01210788
51NTRK21.00328342
52PINK10.99073819
53TRIM280.98174237
54MAP2K60.96347383
55PDK40.95985361
56PDK30.95985361
57PRKCE0.95195302
58MET0.93718597
59CAMKK20.93116423
60MATK0.92854359
61MST40.92216202
62WEE10.91559753
63PLK20.90848500
64GRK50.90758017
65MAPK150.90570089
66DYRK1B0.89532977
67PRKCI0.83964029
68PRKD30.83547571
69BRSK20.83216288
70LMTK20.82424785
71JAK30.81808088
72MAP2K20.81464799
73PHKG20.81016962
74PHKG10.81016962
75MAP3K40.79317535
76RPS6KA40.79183000
77OBSCN0.77859120
78PKN10.76049241
79NEK10.73962391
80RIPK10.73511166
81HIPK20.73090735
82MAPK110.72796328
83PDGFRA0.72624970
84CSF1R0.72578291
85ROCK10.71956815
86FER0.71698413
87PRKD20.71097863
88PASK0.71030023
89MAPK120.69595719
90ACVR1B0.69455726
91TEC0.69418943
92BTK0.69170726
93NME10.68588701
94MAPKAPK30.67617830
95MAP3K70.67228833
96MYLK0.65634098
97KDR0.62593670
98DAPK20.62090909
99KIT0.62013800
100IKBKB0.61584014
101CDK60.61501501
102EPHB20.61440098
103VRK10.58275429
104IRAK30.58107850
105LATS10.57764427
106STK380.57039107
107EPHA20.55506680
108STK30.55465681
109CHUK0.55112054
110JAK20.54593635
111PRKCQ0.52812924
112STK38L0.52407134
113OXSR10.51511725
114MAP2K10.51059152
115CDK40.50891142
116DDR20.50881697
117ZAP700.49631870
118PRKG20.49389688
119RET0.48335602
120ARAF0.47856769
121PAK30.47542668
122ABL20.46500727
123CAMK2D0.46218428
124PRKAA20.45687466
125PIK3CA0.45027126
126CAMK10.44989787
127PAK20.44619475
128NTRK30.44510207
129PRKACA0.44438175
130EPHA30.44432628
131ERBB40.44381947
132IKBKE0.43787938
133GRK70.42212093
134EIF2AK30.41345640
135PRKCG0.41315174
136CAMK2A0.41158159
137FGFR10.40822277
138AKT20.40746536
139TAOK30.40479874
140PRKD10.39123405
141PIM20.39070452
142DYRK20.38449223
143MTOR0.38080572
144STK100.38029190
145CDK80.37847076
146DAPK30.35373756
147CSNK1G30.34227763
148DYRK30.33816032
149CSNK1G20.33631007
150PRKCA0.32559728
151EIF2AK20.31575370
152TRPM70.31393451
153CSNK1G10.31185231
154PTK20.29788045
155PRKAA10.29328312
156PRKG10.28586313
157STK40.28239604
158ILK0.27551547
159TAOK20.26943570
160ERBB20.26935146
161EPHB10.25953486
162PIM10.25644223
163ADRBK10.25379217
164IRAK10.23878456

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.39189254
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26560868
3Fatty acid degradation_Homo sapiens_hsa000712.82488981
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.81091529
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.76662857
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.73407098
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66273591
8Propanoate metabolism_Homo sapiens_hsa006402.50349004
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41456336
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.39344185
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33207931
12Nitrogen metabolism_Homo sapiens_hsa009102.33092394
13Phototransduction_Homo sapiens_hsa047442.32289194
14Sulfur relay system_Homo sapiens_hsa041222.31101889
15Peroxisome_Homo sapiens_hsa041462.27340673
16Tryptophan metabolism_Homo sapiens_hsa003802.24018113
17Arginine biosynthesis_Homo sapiens_hsa002202.14310049
18Caffeine metabolism_Homo sapiens_hsa002322.11296045
19Cardiac muscle contraction_Homo sapiens_hsa042602.10238421
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04545986
21Complement and coagulation cascades_Homo sapiens_hsa046101.94256564
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.93083713
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91998400
24Chemical carcinogenesis_Homo sapiens_hsa052041.90441919
25Butanoate metabolism_Homo sapiens_hsa006501.89030320
26Fatty acid metabolism_Homo sapiens_hsa012121.87820395
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86363651
28beta-Alanine metabolism_Homo sapiens_hsa004101.81749098
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77288030
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.75992502
31Folate biosynthesis_Homo sapiens_hsa007901.75750266
32Sulfur metabolism_Homo sapiens_hsa009201.75414362
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75347735
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72682375
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59611682
36PPAR signaling pathway_Homo sapiens_hsa033201.57446948
37Carbon metabolism_Homo sapiens_hsa012001.56430978
38Selenocompound metabolism_Homo sapiens_hsa004501.49973777
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.48741064
40Basal transcription factors_Homo sapiens_hsa030221.47856718
41Dilated cardiomyopathy_Homo sapiens_hsa054141.47730530
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.47593151
43Olfactory transduction_Homo sapiens_hsa047401.44652726
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44163920
45Pyruvate metabolism_Homo sapiens_hsa006201.42449547
46Fatty acid elongation_Homo sapiens_hsa000621.42368680
47Histidine metabolism_Homo sapiens_hsa003401.42113434
48Ribosome_Homo sapiens_hsa030101.42093877
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41950784
50Biosynthesis of amino acids_Homo sapiens_hsa012301.41015922
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.40888391
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38643035
53Retinol metabolism_Homo sapiens_hsa008301.36144600
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33978274
55Starch and sucrose metabolism_Homo sapiens_hsa005001.31499631
56Huntingtons disease_Homo sapiens_hsa050161.27583766
57Phenylalanine metabolism_Homo sapiens_hsa003601.27361385
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.24801361
59Ether lipid metabolism_Homo sapiens_hsa005651.23491462
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22252845
61Calcium signaling pathway_Homo sapiens_hsa040201.18341428
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17343233
63Nicotine addiction_Homo sapiens_hsa050331.12565812
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11435131
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10051619
66Salivary secretion_Homo sapiens_hsa049701.08079576
67Regulation of autophagy_Homo sapiens_hsa041401.05407672
68Tyrosine metabolism_Homo sapiens_hsa003501.04490610
69Arginine and proline metabolism_Homo sapiens_hsa003301.04390111
70Glycosaminoglycan degradation_Homo sapiens_hsa005311.03828005
71Taste transduction_Homo sapiens_hsa047421.03541867
72Circadian rhythm_Homo sapiens_hsa047101.03016390
73Fat digestion and absorption_Homo sapiens_hsa049751.01797381
74Intestinal immune network for IgA production_Homo sapiens_hsa046721.01312642
75Homologous recombination_Homo sapiens_hsa034401.01128674
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99672446
77Insulin secretion_Homo sapiens_hsa049110.97703419
78Staphylococcus aureus infection_Homo sapiens_hsa051500.97399222
79One carbon pool by folate_Homo sapiens_hsa006700.93356882
80Fanconi anemia pathway_Homo sapiens_hsa034600.91069710
81Glutathione metabolism_Homo sapiens_hsa004800.90661775
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90025950
83ABC transporters_Homo sapiens_hsa020100.84086172
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83936072
85Galactose metabolism_Homo sapiens_hsa000520.82050120
86Morphine addiction_Homo sapiens_hsa050320.81377172
87ECM-receptor interaction_Homo sapiens_hsa045120.81196603
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80288434
89Ovarian steroidogenesis_Homo sapiens_hsa049130.78962057
90Pentose phosphate pathway_Homo sapiens_hsa000300.77200603
91RNA polymerase_Homo sapiens_hsa030200.71501396
92Oxytocin signaling pathway_Homo sapiens_hsa049210.70179543
93Bile secretion_Homo sapiens_hsa049760.69074565
94Vitamin digestion and absorption_Homo sapiens_hsa049770.68573520
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.68430452
96Lysine degradation_Homo sapiens_hsa003100.63935560
97Glycerolipid metabolism_Homo sapiens_hsa005610.62091178
98Metabolic pathways_Homo sapiens_hsa011000.61174599
99Glutamatergic synapse_Homo sapiens_hsa047240.59266696
100Circadian entrainment_Homo sapiens_hsa047130.58005933
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57836472
102Fatty acid biosynthesis_Homo sapiens_hsa000610.57635618
103GABAergic synapse_Homo sapiens_hsa047270.56264542
104Fructose and mannose metabolism_Homo sapiens_hsa000510.55825309
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53996583
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52958280
107Renin secretion_Homo sapiens_hsa049240.51624201
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.49640396
109Serotonergic synapse_Homo sapiens_hsa047260.49356324
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48632184
111Nucleotide excision repair_Homo sapiens_hsa034200.48133200
112* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47571560
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46109013
114Base excision repair_Homo sapiens_hsa034100.46026528
115cAMP signaling pathway_Homo sapiens_hsa040240.45999990
116Hedgehog signaling pathway_Homo sapiens_hsa043400.45386276
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44947236
118Insulin resistance_Homo sapiens_hsa049310.40887203
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34545172
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29319616
121N-Glycan biosynthesis_Homo sapiens_hsa005100.29138787
122Linoleic acid metabolism_Homo sapiens_hsa005910.25288243
123Pyrimidine metabolism_Homo sapiens_hsa002400.23908066
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21998652
125Arachidonic acid metabolism_Homo sapiens_hsa005900.19372868
126Steroid biosynthesis_Homo sapiens_hsa001000.19134134
127Parkinsons disease_Homo sapiens_hsa050120.14724263
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12852237
129Prion diseases_Homo sapiens_hsa050200.12323124
130Legionellosis_Homo sapiens_hsa051340.11610350
131Glucagon signaling pathway_Homo sapiens_hsa049220.11333561
132Bladder cancer_Homo sapiens_hsa052190.10913026
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10621884
134Protein digestion and absorption_Homo sapiens_hsa049740.09854052
135Protein export_Homo sapiens_hsa030600.09765734
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09705051
137Insulin signaling pathway_Homo sapiens_hsa049100.05405858
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.04491375
139AMPK signaling pathway_Homo sapiens_hsa041520.04247514
140Vitamin B6 metabolism_Homo sapiens_hsa007500.02229471
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.00936084
142Oxidative phosphorylation_Homo sapiens_hsa001900.00321323
143Alzheimers disease_Homo sapiens_hsa05010-0.0250437
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0168542
145Notch signaling pathway_Homo sapiens_hsa04330-0.0075246

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