CTDP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.91408194
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.91408194
3modulation by symbiont of host immune response (GO:0052553)4.91408194
4positive regulation by symbiont of host defense response (GO:0052509)4.91408194
5modulation by symbiont of host defense response (GO:0052031)4.91408194
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.91408194
7negative regulation of erythrocyte differentiation (GO:0045647)4.43649363
8nuclear pore complex assembly (GO:0051292)4.39276314
9folic acid-containing compound biosynthetic process (GO:0009396)4.37055486
10nuclear pore organization (GO:0006999)4.34099481
11response to peptidoglycan (GO:0032494)4.27404594
12protein localization to kinetochore (GO:0034501)4.25925810
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19413007
14negative regulation of cell killing (GO:0031342)4.19413007
15macrophage activation involved in immune response (GO:0002281)4.13553739
16DNA unwinding involved in DNA replication (GO:0006268)3.93782582
17detection of other organism (GO:0098543)3.86099640
18mitotic nuclear envelope disassembly (GO:0007077)3.85525775
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78471096
20negative regulation of interleukin-12 production (GO:0032695)3.73973266
21detection of bacterium (GO:0016045)3.72910981
22protein localization to chromosome, centromeric region (GO:0071459)3.68663081
23regulation of gamma-delta T cell activation (GO:0046643)3.65147551
24nuclear envelope disassembly (GO:0051081)3.63036010
25membrane disassembly (GO:0030397)3.63036010
26response to muramyl dipeptide (GO:0032495)3.61888381
27regulation of interferon-beta biosynthetic process (GO:0045357)3.58867653
28DNA replication initiation (GO:0006270)3.55396175
29neutrophil activation involved in immune response (GO:0002283)3.53540911
30pore complex assembly (GO:0046931)3.46183713
31DNA strand elongation involved in DNA replication (GO:0006271)3.43667721
32positive thymic T cell selection (GO:0045059)3.39555473
33immunoglobulin mediated immune response (GO:0016064)3.38541772
34DNA replication-dependent nucleosome organization (GO:0034723)3.37754380
35DNA replication-dependent nucleosome assembly (GO:0006335)3.37754380
36pre-miRNA processing (GO:0031054)3.30848317
37leukocyte aggregation (GO:0070486)3.29951547
38cellular extravasation (GO:0045123)3.26794622
39IMP biosynthetic process (GO:0006188)3.26325016
40regulation of B cell receptor signaling pathway (GO:0050855)3.24852258
41DNA strand elongation (GO:0022616)3.23587915
42formation of translation preinitiation complex (GO:0001731)3.21958938
43detection of external biotic stimulus (GO:0098581)3.21531920
44regulation of translational fidelity (GO:0006450)3.16491126
45heterochromatin organization (GO:0070828)3.15942932
46mitotic chromosome condensation (GO:0007076)3.14353900
47B cell receptor signaling pathway (GO:0050853)3.14016845
48response to host immune response (GO:0052572)3.12331726
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12331726
50negative regulation of histone methylation (GO:0031061)3.12118322
51regulation of leukocyte degranulation (GO:0043300)3.11986395
52DNA duplex unwinding (GO:0032508)3.09892266
53respiratory burst (GO:0045730)3.09009247
54DNA geometric change (GO:0032392)3.08983885
55histone H3-K36 demethylation (GO:0070544)3.08967677
56detection of molecule of bacterial origin (GO:0032490)3.08001424
57dosage compensation (GO:0007549)3.07753052
58regulation of histone H3-K9 methylation (GO:0051570)3.07745164
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07643730
60regulation of mast cell degranulation (GO:0043304)3.03105658
61positive regulation of B cell differentiation (GO:0045579)3.03009542
62DNA replication checkpoint (GO:0000076)3.02044789
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01542678
64germinal center formation (GO:0002467)3.00878730
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00789832
66antigen processing and presentation via MHC class Ib (GO:0002475)3.00607728
67mitotic metaphase plate congression (GO:0007080)3.00333235
68telomere maintenance via semi-conservative replication (GO:0032201)3.00162939
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00125664
70response to host (GO:0075136)3.00125664
71response to host defenses (GO:0052200)3.00125664
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98309676
73regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97946445
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94940739
75IMP metabolic process (GO:0046040)2.94150493
76mitotic sister chromatid cohesion (GO:0007064)2.93000723
77nuclear envelope organization (GO:0006998)2.92699766
78regulation of translational termination (GO:0006449)2.91777909
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91521299
80mitotic sister chromatid segregation (GO:0000070)2.90994240
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.90361726
82regulation of posttranscriptional gene silencing (GO:0060147)2.88721312
83regulation of gene silencing by miRNA (GO:0060964)2.88721312
84regulation of gene silencing by RNA (GO:0060966)2.88721312
85detection of biotic stimulus (GO:0009595)2.88331674
86chromatin assembly (GO:0031497)2.88262262
87regulation of spindle organization (GO:0090224)2.87121772
88mannose metabolic process (GO:0006013)2.86519603
89sister chromatid segregation (GO:0000819)2.86183034
90myeloid cell activation involved in immune response (GO:0002275)2.86100317
91thymic T cell selection (GO:0045061)2.85379254
92regulation of T-helper 2 cell differentiation (GO:0045628)2.83933804
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83864651
94antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83864651
95nucleobase biosynthetic process (GO:0046112)2.83265575
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81514354
97regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80827919
98regulation of type I interferon-mediated signaling pathway (GO:0060338)2.80075376
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79963321
100protein localization to endosome (GO:0036010)2.78424937
101pinocytosis (GO:0006907)2.76828225
102histone H2A monoubiquitination (GO:0035518)2.76631310
103regulation of B cell differentiation (GO:0045577)2.76518610
104negative regulation of lymphocyte mediated immunity (GO:0002707)2.76247856
105T cell selection (GO:0045058)2.76037682
106negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75584675
107negative thymic T cell selection (GO:0045060)2.75090410
108ribosome assembly (GO:0042255)2.74329248
109response to laminar fluid shear stress (GO:0034616)2.74304108
110regulation of RNA export from nucleus (GO:0046831)2.74176565
111maturation of SSU-rRNA (GO:0030490)2.74063404
112type I interferon signaling pathway (GO:0060337)2.73923183
113cellular response to type I interferon (GO:0071357)2.73923183
114negative regulation of leukocyte mediated immunity (GO:0002704)2.73548200
115positive regulation of chromosome segregation (GO:0051984)2.72657925
116tolerance induction (GO:0002507)2.72387291
117negative regulation of T cell mediated immunity (GO:0002710)2.72142552
118response to type I interferon (GO:0034340)2.71946997
119macrophage activation (GO:0042116)2.70999346
120positive T cell selection (GO:0043368)2.69811142
121mitotic G1 DNA damage checkpoint (GO:0031571)2.69104223
122modulation by symbiont of host cellular process (GO:0044068)2.68319342
123chromatin assembly or disassembly (GO:0006333)2.68157344
1243-UTR-mediated mRNA stabilization (GO:0070935)2.68141837
125mRNA stabilization (GO:0048255)2.66795773
126RNA stabilization (GO:0043489)2.66795773
127NIK/NF-kappaB signaling (GO:0038061)2.65236151
128telomere maintenance via recombination (GO:0000722)2.65218312
129positive regulation of Cdc42 GTPase activity (GO:0043089)2.64731115
130regulation of mast cell activation involved in immune response (GO:0033006)2.64142681
131metaphase plate congression (GO:0051310)2.63160927
132response to protozoan (GO:0001562)2.62846769
133B cell mediated immunity (GO:0019724)2.62828147
134T cell migration (GO:0072678)2.62711971
135negative regulation of toll-like receptor signaling pathway (GO:0034122)2.62038279
136defense response to protozoan (GO:0042832)2.62023217
137negative T cell selection (GO:0043383)2.58841006
138protein localization to chromosome (GO:0034502)2.58754324
139antigen processing and presentation of endogenous antigen (GO:0019883)2.58246405
140translesion synthesis (GO:0019985)2.57687741
141negative regulation of RNA splicing (GO:0033119)2.56987902
142NLS-bearing protein import into nucleus (GO:0006607)2.56936786
143regulation of mitotic spindle organization (GO:0060236)2.56734024
144mitotic recombination (GO:0006312)2.55792574
145ribosome biogenesis (GO:0042254)2.55621286
146T cell apoptotic process (GO:0070231)2.54794451
147modulation by virus of host process (GO:0019054)2.53543675
148negative regulation of phagocytosis (GO:0050765)2.52567923
149DNA conformation change (GO:0071103)2.52390826
150regulation of necroptotic process (GO:0060544)2.51551448
151embryonic process involved in female pregnancy (GO:0060136)2.51243106
152granulocyte activation (GO:0036230)2.50383086
153positive regulation of interferon-alpha production (GO:0032727)2.48578092
154positive regulation of gamma-delta T cell activation (GO:0046645)2.47754009
155regulation of regulated secretory pathway (GO:1903305)2.46445888
156negative regulation of innate immune response (GO:0045824)2.45323072
157mitotic G1/S transition checkpoint (GO:0044819)2.43692186
158negative regulation of interleukin-6 production (GO:0032715)2.43413083
159neutrophil activation (GO:0042119)2.43183915
160translational initiation (GO:0006413)2.42885791
161myeloid dendritic cell differentiation (GO:0043011)2.42599427
162viral transcription (GO:0019083)2.42105277
163negative regulation of gene expression, epigenetic (GO:0045814)2.41974103
164positive regulation of type 2 immune response (GO:0002830)2.40968900
165myeloid dendritic cell activation (GO:0001773)2.40695549
166translational termination (GO:0006415)2.39233797
167regulation of tolerance induction (GO:0002643)2.38884266
168regulation of interferon-alpha production (GO:0032647)2.38292733
169telomere maintenance via telomere lengthening (GO:0010833)2.37878358
170purine nucleobase biosynthetic process (GO:0009113)2.37537162
171DNA replication-independent nucleosome assembly (GO:0006336)2.36582999
172DNA replication-independent nucleosome organization (GO:0034724)2.36582999
173ribosomal small subunit assembly (GO:0000028)2.36044173
174regulation of gene silencing (GO:0060968)2.35233915
175nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.35000040
176positive regulation of SMAD protein import into nucleus (GO:0060391)2.34553144
177negative regulation of translational initiation (GO:0045947)2.34341249
178attachment of spindle microtubules to kinetochore (GO:0008608)2.33243644
179regulation of gamma-delta T cell differentiation (GO:0045586)2.32383599
180nucleotide-excision repair, DNA gap filling (GO:0006297)2.31946788
181establishment of chromosome localization (GO:0051303)2.31451286
182regulation of sister chromatid cohesion (GO:0007063)2.30499861
183regulation of chromosome segregation (GO:0051983)2.30446214
184trophectodermal cell differentiation (GO:0001829)2.30241750
185snRNA metabolic process (GO:0016073)2.30194662
186negative regulation of mRNA processing (GO:0050686)2.29807524
187ribonucleoprotein complex biogenesis (GO:0022613)2.29306639
188regulation of translation in response to stress (GO:0043555)2.28552784
189mRNA transport (GO:0051028)2.28222594
190chromosome condensation (GO:0030261)2.27336652
191alternative mRNA splicing, via spliceosome (GO:0000380)2.27241092
192ncRNA 3-end processing (GO:0043628)2.27103396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.96818510
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.05333109
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.56909648
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.05607483
5MYC_22102868_ChIP-Seq_BL_Human3.02532229
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02088178
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84771063
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.57082708
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50724369
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.44390925
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40816502
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32827060
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17396121
14LXR_22292898_ChIP-Seq_THP-1_Human2.15493218
15VDR_21846776_ChIP-Seq_THP-1_Human2.09326445
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02732093
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80261660
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.79847375
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.79332631
20* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77056337
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74669084
22XRN2_22483619_ChIP-Seq_HELA_Human1.74661637
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70574278
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67533388
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67475205
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66124637
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66084686
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.64728056
29* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.63319441
30CIITA_25753668_ChIP-Seq_RAJI_Human1.63303947
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62411348
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59090599
33AR_21909140_ChIP-Seq_LNCAP_Human1.57350551
34SPI1_23127762_ChIP-Seq_K562_Human1.55848066
35TCF7_22412390_ChIP-Seq_EML_Mouse1.53719006
36RACK7_27058665_Chip-Seq_MCF-7_Human1.52699231
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50142930
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49702546
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48712116
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48084210
41* KDM2B_26808549_Chip-Seq_JURKAT_Human1.46446668
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46232495
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45515442
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45283937
45MAF_26560356_Chip-Seq_TH1_Human1.45175283
46* ETS1_20019798_ChIP-Seq_JURKAT_Human1.45032858
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.44374426
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44218127
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43225473
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42734431
51VDR_23849224_ChIP-Seq_CD4+_Human1.42631907
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41594340
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41341098
54* UTX_26944678_Chip-Seq_JUKART_Human1.40216646
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40197757
56TFEB_21752829_ChIP-Seq_HELA_Human1.39968906
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39658978
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37107500
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36790828
60KDM5A_27292631_Chip-Seq_BREAST_Human1.36532302
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36095880
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35321716
63KDM2B_26808549_Chip-Seq_K562_Human1.34172137
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33551942
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32976330
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32085171
67* MYB_26560356_Chip-Seq_TH2_Human1.31956850
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31834756
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.31783866
70* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31298566
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30750206
72* MYB_26560356_Chip-Seq_TH1_Human1.30660119
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.30100683
74RUNX_20019798_ChIP-Seq_JUKART_Human1.30066810
75* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29467015
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.29273312
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28423579
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27677234
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.27238668
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26300926
81FOXP3_21729870_ChIP-Seq_TREG_Human1.26281832
82* GABP_19822575_ChIP-Seq_HepG2_Human1.25246382
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25229499
84DCP1A_22483619_ChIP-Seq_HELA_Human1.24888724
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.24417997
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24316236
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23581893
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.23513463
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23201071
90SPI1_23547873_ChIP-Seq_NB4_Human1.23198469
91P68_20966046_ChIP-Seq_HELA_Human1.22665588
92* KDM2B_26808549_Chip-Seq_DND41_Human1.22368061
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.21657809
94* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21283713
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21024459
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20146074
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18888146
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18662683
99BCOR_27268052_Chip-Seq_Bcells_Human1.18531486
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.18518963
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18133793
102VDR_24763502_ChIP-Seq_THP-1_Human1.17550369
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17095469
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16091215
105* RUNX1_22412390_ChIP-Seq_EML_Mouse1.14489640
106TTF2_22483619_ChIP-Seq_HELA_Human1.14152947
107* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12983709
108IRF8_21731497_ChIP-ChIP_J774_Mouse1.12689428
109SCL_19346495_ChIP-Seq_HPC-7_Human1.11957197
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10591519
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09917503
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09487210
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08969237
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08092410
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08049786
116GATA1_19941826_ChIP-Seq_K562_Human1.07568403
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06352046
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06333630
119* MAF_26560356_Chip-Seq_TH2_Human1.05140105
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04582609
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04177405
122BCL6_27268052_Chip-Seq_Bcells_Human1.04155922
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03933546
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03827763
125* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03716057
126ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03463320
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02701696
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02650848
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02491419
130TET1_21451524_ChIP-Seq_MESCs_Mouse1.02016414
131STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01984764
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01827541
133* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01538392
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01056575
135NCOR1_26117541_ChIP-Seq_K562_Human1.00935789
136* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00568514
137KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00532862
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00135124
139ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00123580
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99958674
141KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99958674
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99958674
143SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99435477
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98872503
145EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97823009
146SMC4_20622854_ChIP-Seq_HELA_Human0.97525514
147PU_27001747_Chip-Seq_BMDM_Mouse0.97162380
148* ATF3_27146783_Chip-Seq_COLON_Human0.96890942
149RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94762954
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94694856
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94669010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.40120536
2MP0010352_gastrointestinal_tract_polyps3.18764992
3MP0008057_abnormal_DNA_replication3.08537446
4MP0003111_abnormal_nucleus_morphology2.93609207
5MP0004957_abnormal_blastocyst_morpholog2.91014290
6MP0008260_abnormal_autophagy2.81349239
7MP0003077_abnormal_cell_cycle2.79333492
8MP0010094_abnormal_chromosome_stability2.73650437
9MP0003705_abnormal_hypodermis_morpholog2.55548414
10MP0005451_abnormal_body_composition2.43681335
11MP0005076_abnormal_cell_differentiation2.39358361
12MP0010307_abnormal_tumor_latency2.29292655
13MP0003724_increased_susceptibility_to2.26497963
14MP0002396_abnormal_hematopoietic_system2.24355764
15MP0005058_abnormal_lysosome_morphology2.19390036
16MP0001730_embryonic_growth_arrest1.97013767
17MP0004808_abnormal_hematopoietic_stem1.94973126
18MP0002148_abnormal_hypersensitivity_rea1.89087513
19MP0000350_abnormal_cell_proliferation1.87563347
20MP0000685_abnormal_immune_system1.85895316
21MP0003191_abnormal_cellular_cholesterol1.84945671
22MP0003303_peritoneal_inflammation1.83505074
23MP0001835_abnormal_antigen_presentation1.83423523
24MP0009278_abnormal_bone_marrow1.83240066
25MP0008007_abnormal_cellular_replicative1.81782443
26MP0003436_decreased_susceptibility_to1.79293588
27MP0003763_abnormal_thymus_physiology1.70607919
28MP0002398_abnormal_bone_marrow1.68096426
29MP0003566_abnormal_cell_adhesion1.66027497
30MP0008058_abnormal_DNA_repair1.63271996
31MP0005397_hematopoietic_system_phenotyp1.62924086
32MP0001545_abnormal_hematopoietic_system1.62924086
33MP0006082_CNS_inflammation1.60101470
34MP0001800_abnormal_humoral_immune1.58366051
35MP0009333_abnormal_splenocyte_physiolog1.55235241
36MP0000490_abnormal_crypts_of1.52460840
37MP0005380_embryogenesis_phenotype1.46237292
38MP0001672_abnormal_embryogenesis/_devel1.46237292
39MP0002998_abnormal_bone_remodeling1.45801322
40MP0000703_abnormal_thymus_morphology1.45720296
41MP0003984_embryonic_growth_retardation1.43737345
42MP0002722_abnormal_immune_system1.43009496
43MP0002088_abnormal_embryonic_growth/wei1.42234634
44MP0002086_abnormal_extraembryonic_tissu1.41582702
45MP0001697_abnormal_embryo_size1.40007747
46MP0002254_reproductive_system_inflammat1.39022385
47MP0002452_abnormal_antigen_presenting1.38143955
48MP0000689_abnormal_spleen_morphology1.37949290
49MP0004197_abnormal_fetal_growth/weight/1.37645249
50MP0005023_abnormal_wound_healing1.37263410
51MP0005310_abnormal_salivary_gland1.36882155
52MP0002019_abnormal_tumor_incidence1.35812733
53MP0008932_abnormal_embryonic_tissue1.35121551
54MP0002405_respiratory_system_inflammati1.33769105
55MP0004947_skin_inflammation1.33293590
56MP0002877_abnormal_melanocyte_morpholog1.32138962
57MP0002080_prenatal_lethality1.31183651
58MP0003828_pulmonary_edema1.31050636
59MP0002420_abnormal_adaptive_immunity1.31023752
60MP0000716_abnormal_immune_system1.30247767
61MP0005671_abnormal_response_to1.30077486
62MP0001819_abnormal_immune_cell1.29514316
63MP0002084_abnormal_developmental_patter1.28922942
64MP0003300_gastrointestinal_ulcer1.27216384
65MP0002723_abnormal_immune_serum1.26676894
66MP0002429_abnormal_blood_cell1.26013823
67MP0002085_abnormal_embryonic_tissue1.24421545
68MP0000858_altered_metastatic_potential1.23986354
69MP0005000_abnormal_immune_tolerance1.21639759
70MP0002166_altered_tumor_susceptibility1.20381808
71MP0001849_ear_inflammation1.19030500
72MP0001790_abnormal_immune_system1.18804478
73MP0005387_immune_system_phenotype1.18804478
74MP0000313_abnormal_cell_death1.16184637
75MP0003123_paternal_imprinting1.16056887
76MP0003172_abnormal_lysosome_physiology1.13802842
77MP0006054_spinal_hemorrhage1.13334404
78MP0008469_abnormal_protein_level1.12056433
79MP0002796_impaired_skin_barrier1.11732192
80MP0001873_stomach_inflammation1.11465507
81MP0000733_abnormal_muscle_development1.08862335
82MP0008004_abnormal_stomach_pH1.06303572
83MP0000569_abnormal_digit_pigmentation1.04666321
84MP0003183_abnormal_peptide_metabolism1.04221507
85MP0003075_altered_response_to1.03635474
86MP0001851_eye_inflammation1.02771179
87MP0003448_altered_tumor_morphology1.01709033
88MP0004381_abnormal_hair_follicle1.01389596
89MP0003866_abnormal_defecation1.00653735
90MP0008877_abnormal_DNA_methylation1.00501299
91MP0003656_abnormal_erythrocyte_physiolo0.96227261
92MP0000465_gastrointestinal_hemorrhage0.95156204
93MP0003091_abnormal_cell_migration0.94824893
94MP0002006_tumorigenesis0.94582067
95MP0005025_abnormal_response_to0.94366135
96MP0001915_intracranial_hemorrhage0.93832628
97MP0002138_abnormal_hepatobiliary_system0.92845180
98MP0004858_abnormal_nervous_system0.92536694
99MP0003786_premature_aging0.92265014
100MP0010155_abnormal_intestine_physiology0.92161905
101MP0005621_abnormal_cell_physiology0.91993306
102MP0009764_decreased_sensitivity_to0.90390053
103MP0003890_abnormal_embryonic-extraembry0.90209950
104MP0009840_abnormal_foam_cell0.90123524
105MP0005464_abnormal_platelet_physiology0.89401838
106MP0000604_amyloidosis0.87874118
107MP0004510_myositis0.87416342
108MP0002419_abnormal_innate_immunity0.87241351
109MP0003567_abnormal_fetal_cardiomyocyte0.84898039
110MP0005666_abnormal_adipose_tissue0.82091993
111MP0002132_abnormal_respiratory_system0.80814679
112MP0005384_cellular_phenotype0.79663547
113MP0000343_altered_response_to0.79516025
114MP0004233_abnormal_muscle_weight0.78108693
115MP0003453_abnormal_keratinocyte_physiol0.76990712
116MP0001845_abnormal_inflammatory_respons0.76494235
117MP0002933_joint_inflammation0.76203713
118MP0002653_abnormal_ependyma_morphology0.75979990
119MP0001853_heart_inflammation0.75118307
120MP0010234_abnormal_vibrissa_follicle0.74667248
121MP0003221_abnormal_cardiomyocyte_apopto0.74278594
122MP0005390_skeleton_phenotype0.73414569
123MP0000371_diluted_coat_color0.73348443
124MP0001533_abnormal_skeleton_physiology0.73302550
125MP0008961_abnormal_basal_metabolism0.73174664
126MP0001348_abnormal_lacrimal_gland0.71522522
127MP0005501_abnormal_skin_physiology0.70956935
128MP0000358_abnormal_cell_content/0.70496113
129MP0005166_decreased_susceptibility_to0.70471857
130MP0009785_altered_susceptibility_to0.70194843
131MP0002092_abnormal_eye_morphology0.69712702
132MP0000477_abnormal_intestine_morphology0.69195991
133MP0004185_abnormal_adipocyte_glucose0.69167804
134MP0009931_abnormal_skin_appearance0.66529913
135MP0001663_abnormal_digestive_system0.66230556
136MP0005375_adipose_tissue_phenotype0.65909148
137MP0009763_increased_sensitivity_to0.65841400
138MP0003795_abnormal_bone_structure0.65521014

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.27615368
2Recurrent abscess formation (HP:0002722)4.20359738
3Abnormality of macrophages (HP:0004311)4.10781894
4Myositis (HP:0100614)3.54432311
5Ependymoma (HP:0002888)3.43148416
6Orchitis (HP:0100796)3.36317403
7Mediastinal lymphadenopathy (HP:0100721)3.31129159
8Recurrent gram-negative bacterial infections (HP:0005420)3.08618698
9Increased IgE level (HP:0003212)3.07235321
10Chronic obstructive pulmonary disease (HP:0006510)3.02234487
11Obstructive lung disease (HP:0006536)3.02234487
12IgM deficiency (HP:0002850)3.00883236
13Meningitis (HP:0001287)2.98605006
14Gingivitis (HP:0000230)2.95800055
15Optic neuritis (HP:0100653)2.88714022
16Retrobulbar optic neuritis (HP:0100654)2.88714022
17Abnormality of the fingertips (HP:0001211)2.83364640
18Colitis (HP:0002583)2.73151312
19Selective tooth agenesis (HP:0001592)2.72268397
20Recurrent skin infections (HP:0001581)2.68771189
21Gastrointestinal infarctions (HP:0005244)2.60443733
22Vasculitis (HP:0002633)2.58141997
23Cerebral aneurysm (HP:0004944)2.56663922
24Nasal polyposis (HP:0100582)2.56326949
25Spontaneous hematomas (HP:0007420)2.55360168
26Stomatitis (HP:0010280)2.54649500
27Abnormality of liposaccharide metabolism (HP:0010968)2.49910644
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.49910644
29Abnormality of glycolipid metabolism (HP:0010969)2.49910644
30Basal cell carcinoma (HP:0002671)2.48678538
31Osteomyelitis (HP:0002754)2.41352782
32Birth length less than 3rd percentile (HP:0003561)2.40934536
33Increased cerebral lipofuscin (HP:0011813)2.38602457
34Thrombocytosis (HP:0001894)2.37946850
35Gastrointestinal stroma tumor (HP:0100723)2.34593827
36Prominent nose (HP:0000448)2.34246278
37Urticaria (HP:0001025)2.32804008
38Thoracic kyphosis (HP:0002942)2.31158341
39Hyperacusis (HP:0010780)2.29506162
40Abnormality of the astrocytes (HP:0100707)2.29262522
41Astrocytoma (HP:0009592)2.29262522
42Agnosia (HP:0010524)2.26845265
43Recurrent cutaneous fungal infections (HP:0011370)2.26083238
44Chronic mucocutaneous candidiasis (HP:0002728)2.26083238
45Recurrent bronchitis (HP:0002837)2.20543279
46Loss of speech (HP:0002371)2.19439313
47Patellar aplasia (HP:0006443)2.19168028
48Agammaglobulinemia (HP:0004432)2.19060623
49Increased density of long bones (HP:0006392)2.18685338
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.18587171
51Abnormality of the anterior horn cell (HP:0006802)2.18575132
52Degeneration of anterior horn cells (HP:0002398)2.18575132
53Cellulitis (HP:0100658)2.18560715
54Abnormality of the thoracic spine (HP:0100711)2.18527351
55Prolonged bleeding time (HP:0003010)2.16126280
56Keratoconjunctivitis sicca (HP:0001097)2.14597855
57Long eyelashes (HP:0000527)2.14350852
58Deviation of the thumb (HP:0009603)2.14165779
59Polygenic inheritance (HP:0010982)2.14002842
60Chest pain (HP:0100749)2.12870285
61Multiple enchondromatosis (HP:0005701)2.12381045
62Dysostosis multiplex (HP:0000943)2.09680676
63Colon cancer (HP:0003003)2.09583507
64Autoimmune thrombocytopenia (HP:0001973)2.09546526
65Proximal placement of thumb (HP:0009623)2.09119894
66Abnormality of the nasal mucosa (HP:0000433)2.08750046
67Lymphopenia (HP:0001888)2.06979412
68Slow saccadic eye movements (HP:0000514)2.06786689
69Recurrent viral infections (HP:0004429)2.06588308
70Segmental peripheral demyelination/remyelination (HP:0003481)2.06510278
71Amaurosis fugax (HP:0100576)2.06207005
72Increased nuchal translucency (HP:0010880)2.05688922
73Abnormality of cells of the erythroid lineage (HP:0012130)2.05419737
74Encephalitis (HP:0002383)2.03240847
75Epistaxis (HP:0000421)2.02412958
76Myelodysplasia (HP:0002863)2.01937460
77Increased serum ferritin (HP:0003281)2.01782634
78Peritonitis (HP:0002586)2.01626792
79Amyloidosis (HP:0011034)2.01168028
80Medulloblastoma (HP:0002885)2.00459523
81Carpal bone hypoplasia (HP:0001498)2.00344816
82Aplasia/Hypoplasia of the patella (HP:0006498)2.00027332
83T lymphocytopenia (HP:0005403)1.97330162
84Increased neuronal autofluorescent lipopigment (HP:0002074)1.96683517
85Arterial thrombosis (HP:0004420)1.95910579
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93578922
87Thin bony cortex (HP:0002753)1.93529258
88Short 4th metacarpal (HP:0010044)1.92797902
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92797902
90Abnormality of T cell number (HP:0011839)1.92797305
91Distal lower limb amyotrophy (HP:0008944)1.91042661
92Increased connective tissue (HP:0009025)1.90187777
93Hand muscle atrophy (HP:0009130)1.90174860
94Ulnar bowing (HP:0003031)1.90167061
95Interstitial pulmonary disease (HP:0006530)1.89613253
96Petechiae (HP:0000967)1.89329021
97Upper motor neuron abnormality (HP:0002127)1.89282121
98Premature loss of primary teeth (HP:0006323)1.88963667
99Long palpebral fissure (HP:0000637)1.88556912
100Rhabdomyosarcoma (HP:0002859)1.88522159
101Ankle contracture (HP:0006466)1.88338828
102Sepsis (HP:0100806)1.87685979
103Lymphoma (HP:0002665)1.87626206
104Pulmonary infiltrates (HP:0002113)1.87553756
105Viral hepatitis (HP:0006562)1.87231386
106Progressive external ophthalmoplegia (HP:0000590)1.85868567
107Malnutrition (HP:0004395)1.84206558
108Skin ulcer (HP:0200042)1.83874709
109Hemoptysis (HP:0002105)1.83065096
110High pitched voice (HP:0001620)1.82376632
111Overlapping toe (HP:0001845)1.81801482
112Neoplasm of the pancreas (HP:0002894)1.81238596
113Polycythemia (HP:0001901)1.80232951
114Skin tags (HP:0010609)1.79494672
115Hypertensive crisis (HP:0100735)1.79470103
116Papilloma (HP:0012740)1.79378065
117Verrucae (HP:0200043)1.79378065
118Cervical subluxation (HP:0003308)1.78862876
119Neuronal loss in central nervous system (HP:0002529)1.78856863
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.78710041
121Trismus (HP:0000211)1.77955400
122Neoplasm of striated muscle (HP:0009728)1.77888367
123Keratoconjunctivitis (HP:0001096)1.77725178
124Abnormal number of erythroid precursors (HP:0012131)1.77391953
125Abnormality of T cells (HP:0002843)1.77377475
126Glioma (HP:0009733)1.77022627
127Recurrent fungal infections (HP:0002841)1.76866951
128Reticulocytopenia (HP:0001896)1.76254634
129Abnormality of the calcaneus (HP:0008364)1.75779083
130Hypochromic anemia (HP:0001931)1.74910844
131Glomerulopathy (HP:0100820)1.74796573
132Cafe-au-lait spot (HP:0000957)1.74363400
133Gastrointestinal inflammation (HP:0004386)1.74352874
134Purpura (HP:0000979)1.73630306
135Myocardial infarction (HP:0001658)1.73565472
136Protrusio acetabuli (HP:0003179)1.73302728
137Impulsivity (HP:0100710)1.72363147
138Preauricular skin tag (HP:0000384)1.72185650
139Restrictive lung disease (HP:0002091)1.71905674
140Subacute progressive viral hepatitis (HP:0006572)1.71415758
141Malignant gastrointestinal tract tumors (HP:0006749)1.71218186
142Gastrointestinal carcinoma (HP:0002672)1.71218186
143Bicuspid aortic valve (HP:0001647)1.71157644
144Biliary tract neoplasm (HP:0100574)1.70876326
145Volvulus (HP:0002580)1.70842014
146Urethral obstruction (HP:0000796)1.70590876
147Eczematoid dermatitis (HP:0000976)1.69991806
148Emphysema (HP:0002097)1.69478997
149Hypergammaglobulinemia (HP:0010702)1.69435024
150Leukocytosis (HP:0001974)1.69168026
151Fatigue (HP:0012378)1.68988826
152Breast hypoplasia (HP:0003187)1.68869517
153Upper limb amyotrophy (HP:0009129)1.68827916
154Distal upper limb amyotrophy (HP:0007149)1.68827916
155Rough bone trabeculation (HP:0100670)1.68617147
156Elevated erythrocyte sedimentation rate (HP:0003565)1.68491439
157Abnormality of cells of the lymphoid lineage (HP:0012140)1.68444917
158Limited elbow extension (HP:0001377)1.66903653
159Osteolytic defects of the phalanges of the hand (HP:0009771)1.66780665
160Osteolytic defects of the hand bones (HP:0009699)1.66780665
161Broad palm (HP:0001169)1.65762864
162Abnormality of chromosome stability (HP:0003220)1.63583764
163Spinal muscular atrophy (HP:0007269)1.62459481
164Abnormality of the peritoneum (HP:0002585)1.62008007
165* Genu recurvatum (HP:0002816)1.61932878
166Abnormal number of incisors (HP:0011064)1.61611431
167Persistence of primary teeth (HP:0006335)1.59485053
168Atresia of the external auditory canal (HP:0000413)1.58862190
169Entropion (HP:0000621)1.57388790
170Inflammation of the large intestine (HP:0002037)1.57310648
171Acute myeloid leukemia (HP:0004808)1.56844903
172Pustule (HP:0200039)1.56044160
173Mitral valve prolapse (HP:0001634)1.55663632
174Poikiloderma (HP:0001029)1.54699506
175Broad face (HP:0000283)1.54386343
176Sparse lateral eyebrow (HP:0005338)1.54304514
177IgA deficiency (HP:0002720)1.54282631
178Chronic otitis media (HP:0000389)1.54258493
179Adenoma sebaceum (HP:0009720)1.54205018
180Angiofibromas (HP:0010615)1.54205018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.64859361
2CDK123.46634846
3MAP3K103.23678604
4EEF2K3.11176879
5MAP4K12.88991785
6SMG12.82005242
7CDC72.78987733
8RIPK42.63232465
9NEK22.42637133
10PKN22.38581209
11TRIB32.33943112
12WEE12.32620744
13IRAK42.14086874
14STK102.11992013
15IRAK32.09284081
16BUB12.03065443
17TESK21.95774585
18RPS6KA41.87875022
19PASK1.82151262
20MAP3K131.80508162
21MAP3K141.75433463
22RPS6KB21.74023111
23SIK11.66734856
24TAOK21.65016074
25SCYL21.63504444
26CDK41.63096392
27ERN11.59775403
28FES1.55352238
29GRK61.51294447
30MAP3K11.47933684
31DYRK31.42163285
32JAK31.41852898
33MAP3K81.41755308
34EPHA21.35776750
35ACVR1B1.34947282
36CSF1R1.34819646
37TTK1.30792367
38PAK41.30734307
39IKBKE1.28890734
40LRRK21.27027660
41TSSK61.26641185
42CDK71.26388755
43ZAP701.25507798
44PIM11.23889577
45EIF2AK11.23756488
46ALK1.22810899
47ATR1.19822037
48KSR21.15639379
49FGR1.13903795
50MARK21.13795821
51FLT31.13456592
52TTN1.12830711
53SIK21.07972310
54NME21.07071190
55EPHB11.06599248
56PTK61.05517448
57MTOR1.03580921
58PLK11.01814718
59STK31.01539159
60AURKB1.01318964
61BTK1.00443543
62EIF2AK30.99607849
63CHEK10.99008707
64TYK20.95167346
65MATK0.94863027
66CDK60.94161915
67IRAK20.91219369
68MELK0.91101252
69MAP2K30.89563410
70BRSK20.87022745
71CDC42BPA0.86672099
72TNK20.85627007
73TBK10.84833279
74ICK0.84392189
75STK40.84024485
76CHUK0.83542964
77FGFR40.83106953
78CHEK20.81871334
79IKBKB0.81278873
80TGFBR10.80871685
81PDGFRA0.80668405
82PAK20.80445793
83LYN0.79986657
84SIK30.79689694
85RPS6KL10.77464377
86RPS6KC10.77464377
87ITK0.77414700
88PRKD20.77035927
89MAP3K110.76765582
90MAPKAPK30.76355296
91ARAF0.72611834
92BLK0.71637686
93PDPK10.71378187
94PIM20.71251787
95TGFBR20.71028308
96TLK10.69709510
97* CDK20.69129521
98BRD40.68449767
99HIPK20.65807109
100JAK10.65285894
101SRPK10.63947135
102BMX0.63770104
103HCK0.63137211
104PDK10.63107515
105ATM0.62716266
106TESK10.61937664
107CDK190.59745660
108RPS6KA20.58936065
109MAPK110.56220993
110IRAK10.56056023
111BRAF0.55922565
112RPS6KA60.55571746
113MAP3K30.55386666
114CSK0.55375619
115PAK10.55042035
116MOS0.53811990
117KDR0.52432062
118LATS10.52018191
119LCK0.51531978
120DYRK1B0.51179530
121AURKA0.51139588
122BRSK10.49824198
123PDGFRB0.48013937
124MAP3K60.47503406
125SYK0.47028434
126CDK90.46161634
127MAP3K20.45975086
128TAOK10.45932733
129RPS6KA10.45543788
130MAPK70.45114685
131TXK0.44642437
132NEK10.44542021
133RAF10.42720032
134KIT0.41926062
135RIPK10.41711667
136TYRO30.41157031
137JAK20.40983119
138MAPK120.40635875
139RPS6KA50.40561602
140MAPKAPK20.40207942
141FGFR30.38403531
142CDK10.38182014
143CAMK1D0.38028952
144RET0.37871526
145MAP2K20.37185147
146MARK30.32828494
147EGFR0.32822832

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.58294281
2Mismatch repair_Homo sapiens_hsa034302.75193217
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72114553
4RNA transport_Homo sapiens_hsa030132.53243113
5Spliceosome_Homo sapiens_hsa030402.33984744
6Cell cycle_Homo sapiens_hsa041102.22798290
7One carbon pool by folate_Homo sapiens_hsa006702.20394769
8Base excision repair_Homo sapiens_hsa034102.19610037
9Other glycan degradation_Homo sapiens_hsa005112.14117399
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99822601
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87865976
12Homologous recombination_Homo sapiens_hsa034401.79660336
13Antigen processing and presentation_Homo sapiens_hsa046121.78054206
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71156010
15Nucleotide excision repair_Homo sapiens_hsa034201.67520670
16Ribosome_Homo sapiens_hsa030101.59083832
17p53 signaling pathway_Homo sapiens_hsa041151.54985174
18Staphylococcus aureus infection_Homo sapiens_hsa051501.51347218
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.47150471
20mRNA surveillance pathway_Homo sapiens_hsa030151.46813052
21B cell receptor signaling pathway_Homo sapiens_hsa046621.45952968
22Herpes simplex infection_Homo sapiens_hsa051681.44342270
23Viral carcinogenesis_Homo sapiens_hsa052031.43542959
24Chronic myeloid leukemia_Homo sapiens_hsa052201.42976097
25Systemic lupus erythematosus_Homo sapiens_hsa053221.42067439
26RNA polymerase_Homo sapiens_hsa030201.41779733
27Primary immunodeficiency_Homo sapiens_hsa053401.39301175
28Graft-versus-host disease_Homo sapiens_hsa053321.34636624
29Non-homologous end-joining_Homo sapiens_hsa034501.32688520
30Fanconi anemia pathway_Homo sapiens_hsa034601.32471359
31Autoimmune thyroid disease_Homo sapiens_hsa053201.31285473
32Pyrimidine metabolism_Homo sapiens_hsa002401.29284253
33Epstein-Barr virus infection_Homo sapiens_hsa051691.28671967
34Leishmaniasis_Homo sapiens_hsa051401.25923802
35Hepatitis C_Homo sapiens_hsa051601.24212235
36Legionellosis_Homo sapiens_hsa051341.23403065
37Small cell lung cancer_Homo sapiens_hsa052221.22313875
38MicroRNAs in cancer_Homo sapiens_hsa052061.21949603
39HTLV-I infection_Homo sapiens_hsa051661.21017870
40Apoptosis_Homo sapiens_hsa042101.18124744
41RNA degradation_Homo sapiens_hsa030181.16954840
42Chemokine signaling pathway_Homo sapiens_hsa040621.14163886
43Renal cell carcinoma_Homo sapiens_hsa052111.12135948
44Endometrial cancer_Homo sapiens_hsa052131.11467477
45Osteoclast differentiation_Homo sapiens_hsa043801.11383772
46Measles_Homo sapiens_hsa051621.10581960
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08991099
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08783685
49Shigellosis_Homo sapiens_hsa051311.07468002
50Acute myeloid leukemia_Homo sapiens_hsa052211.07145323
51T cell receptor signaling pathway_Homo sapiens_hsa046601.06676798
52Hepatitis B_Homo sapiens_hsa051611.01374090
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00091223
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99190443
55Lysosome_Homo sapiens_hsa041420.98910612
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98036708
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95998908
58Proteasome_Homo sapiens_hsa030500.95717900
59mTOR signaling pathway_Homo sapiens_hsa041500.94415760
60Toxoplasmosis_Homo sapiens_hsa051450.91244293
61Phagosome_Homo sapiens_hsa041450.88937243
62Folate biosynthesis_Homo sapiens_hsa007900.88825996
63Non-small cell lung cancer_Homo sapiens_hsa052230.88682571
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87925753
65Pertussis_Homo sapiens_hsa051330.87882722
66Notch signaling pathway_Homo sapiens_hsa043300.87038244
67Asthma_Homo sapiens_hsa053100.86876286
68Viral myocarditis_Homo sapiens_hsa054160.86747257
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86310159
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.85921955
71Colorectal cancer_Homo sapiens_hsa052100.85915678
72Amoebiasis_Homo sapiens_hsa051460.85889182
73TNF signaling pathway_Homo sapiens_hsa046680.85542177
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.84052566
75Thyroid cancer_Homo sapiens_hsa052160.82872334
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82494448
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82442916
78Pancreatic cancer_Homo sapiens_hsa052120.81916894
79Pentose phosphate pathway_Homo sapiens_hsa000300.81765679
80Influenza A_Homo sapiens_hsa051640.80398340
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.80261192
82Selenocompound metabolism_Homo sapiens_hsa004500.79228920
83Sulfur relay system_Homo sapiens_hsa041220.77927234
84Proteoglycans in cancer_Homo sapiens_hsa052050.77814063
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.77590225
86ErbB signaling pathway_Homo sapiens_hsa040120.76812832
87Basal transcription factors_Homo sapiens_hsa030220.76541295
88African trypanosomiasis_Homo sapiens_hsa051430.76117344
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75214150
90Prion diseases_Homo sapiens_hsa050200.74712900
91Type I diabetes mellitus_Homo sapiens_hsa049400.74670971
92Endocytosis_Homo sapiens_hsa041440.74230062
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.72395823
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72056437
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.71321257
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.71289233
97Hematopoietic cell lineage_Homo sapiens_hsa046400.71130120
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.70076298
99Bladder cancer_Homo sapiens_hsa052190.69829552
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69778487
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69521812
102Adherens junction_Homo sapiens_hsa045200.69070414
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67061837
104Rheumatoid arthritis_Homo sapiens_hsa053230.65676537
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64878484
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.64844827
107VEGF signaling pathway_Homo sapiens_hsa043700.64394564
108Glioma_Homo sapiens_hsa052140.63661664
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63251501
110Inositol phosphate metabolism_Homo sapiens_hsa005620.62479746
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59693674
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59627244
113Lysine degradation_Homo sapiens_hsa003100.58598565
114Choline metabolism in cancer_Homo sapiens_hsa052310.58538248
115Prostate cancer_Homo sapiens_hsa052150.57432070
116Salmonella infection_Homo sapiens_hsa051320.57151940
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56840617
118TGF-beta signaling pathway_Homo sapiens_hsa043500.56449160
119HIF-1 signaling pathway_Homo sapiens_hsa040660.56362210
120GnRH signaling pathway_Homo sapiens_hsa049120.55824594
121Malaria_Homo sapiens_hsa051440.55633798
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55364420
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55127250
124Insulin signaling pathway_Homo sapiens_hsa049100.54957659
125Pathways in cancer_Homo sapiens_hsa052000.54245388
126Insulin resistance_Homo sapiens_hsa049310.53427655
127MAPK signaling pathway_Homo sapiens_hsa040100.52423165
128Allograft rejection_Homo sapiens_hsa053300.52110900
129Tuberculosis_Homo sapiens_hsa051520.51789728
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51732088
131Galactose metabolism_Homo sapiens_hsa000520.50153460
132Oocyte meiosis_Homo sapiens_hsa041140.50027990
133Hippo signaling pathway_Homo sapiens_hsa043900.49008583
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46735246
135FoxO signaling pathway_Homo sapiens_hsa040680.46683865
136Prolactin signaling pathway_Homo sapiens_hsa049170.45974446
137Platelet activation_Homo sapiens_hsa046110.44835701
138Focal adhesion_Homo sapiens_hsa045100.43282703

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