CTCF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.79906789
2protein localization to kinetochore (GO:0034501)4.76319543
3mitotic sister chromatid cohesion (GO:0007064)4.52464676
4mitotic chromosome condensation (GO:0007076)4.29228796
5protein localization to chromosome, centromeric region (GO:0071459)4.28796276
6nuclear pore complex assembly (GO:0051292)4.25322982
7nuclear pore organization (GO:0006999)4.12664175
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.05483814
9kinetochore organization (GO:0051383)4.04349958
10establishment of integrated proviral latency (GO:0075713)4.01162436
11sister chromatid segregation (GO:0000819)3.92476695
12DNA ligation (GO:0006266)3.92453693
13negative regulation of histone methylation (GO:0031061)3.91429197
14ribosomal small subunit assembly (GO:0000028)3.85418640
15regulation of histone H3-K9 methylation (GO:0051570)3.75053382
16mitotic sister chromatid segregation (GO:0000070)3.70291671
17negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68162006
18negative regulation of RNA splicing (GO:0033119)3.66829531
19pre-miRNA processing (GO:0031054)3.59286263
20mitotic nuclear envelope disassembly (GO:0007077)3.57206230
21DNA duplex unwinding (GO:0032508)3.56648016
22DNA geometric change (GO:0032392)3.55256002
23regulation of spindle organization (GO:0090224)3.53424674
24mitotic metaphase plate congression (GO:0007080)3.49186815
25DNA strand elongation involved in DNA replication (GO:0006271)3.48110231
26DNA topological change (GO:0006265)3.47932769
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45553059
28maturation of SSU-rRNA (GO:0030490)3.44074063
29positive regulation of chromosome segregation (GO:0051984)3.44046688
30* regulation of histone methylation (GO:0031060)3.43118575
31viral transcription (GO:0019083)3.41691214
32non-recombinational repair (GO:0000726)3.41226256
33double-strand break repair via nonhomologous end joining (GO:0006303)3.41226256
34metaphase plate congression (GO:0051310)3.40297108
35protein localization to chromosome (GO:0034502)3.38668351
36translational termination (GO:0006415)3.38574563
37DNA replication initiation (GO:0006270)3.38051452
38positive regulation of histone methylation (GO:0031062)3.37798281
39sister chromatid cohesion (GO:0007062)3.35226028
40DNA strand elongation (GO:0022616)3.33569160
41nuclear envelope disassembly (GO:0051081)3.32647676
42membrane disassembly (GO:0030397)3.32647676
43mitotic G2/M transition checkpoint (GO:0044818)3.32558480
44negative regulation of mRNA processing (GO:0050686)3.30721423
45DNA replication-independent nucleosome assembly (GO:0006336)3.29399428
46DNA replication-independent nucleosome organization (GO:0034724)3.29399428
47DNA synthesis involved in DNA repair (GO:0000731)3.27600649
48positive regulation of mitotic sister chromatid separation (GO:1901970)3.27469485
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.27469485
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.27469485
51V(D)J recombination (GO:0033151)3.26521236
52mitotic recombination (GO:0006312)3.25069847
53DNA packaging (GO:0006323)3.24258482
54kinetochore assembly (GO:0051382)3.23662095
55regulation of DNA methylation (GO:0044030)3.23263300
56dosage compensation (GO:0007549)3.23046505
57regulation of RNA export from nucleus (GO:0046831)3.22168664
58attachment of spindle microtubules to kinetochore (GO:0008608)3.19876298
59regulation of DNA endoreduplication (GO:0032875)3.17774063
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17612457
61histone H2B ubiquitination (GO:0033523)3.16850672
62DNA replication checkpoint (GO:0000076)3.16725368
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16701002
64* chromatin assembly or disassembly (GO:0006333)3.15877548
65protein complex localization (GO:0031503)3.15868105
66CENP-A containing nucleosome assembly (GO:0034080)3.15611832
67telomere maintenance via semi-conservative replication (GO:0032201)3.15036234
68establishment of chromosome localization (GO:0051303)3.14154723
69chromatin remodeling at centromere (GO:0031055)3.13508422
70DNA strand renaturation (GO:0000733)3.13244226
71ATP-dependent chromatin remodeling (GO:0043044)3.12335008
72regulation of nucleobase-containing compound transport (GO:0032239)3.11811642
73pore complex assembly (GO:0046931)3.11362193
74telomere maintenance via telomere lengthening (GO:0010833)3.10908840
75histone H3-K4 trimethylation (GO:0080182)3.10300000
76meiotic chromosome segregation (GO:0045132)3.10069492
77negative regulation of mRNA metabolic process (GO:1903312)3.08064419
78DNA replication-dependent nucleosome assembly (GO:0006335)3.05085953
79DNA replication-dependent nucleosome organization (GO:0034723)3.05085953
80DNA conformation change (GO:0071103)3.04422027
81mRNA stabilization (GO:0048255)3.03247729
82RNA stabilization (GO:0043489)3.03247729
83alternative mRNA splicing, via spliceosome (GO:0000380)3.03024540
84telomere maintenance via recombination (GO:0000722)2.99875397
85regulation of mitotic spindle organization (GO:0060236)2.98058485
86heterochromatin organization (GO:0070828)2.96639168
87* regulation of sister chromatid cohesion (GO:0007063)2.96261073
88regulation of centrosome cycle (GO:0046605)2.94554987
89translational elongation (GO:0006414)2.94167774
903-UTR-mediated mRNA stabilization (GO:0070935)2.91062701
91mitotic G2 DNA damage checkpoint (GO:0007095)2.89123671
92regulation of mRNA stability (GO:0043488)2.88950647
93regulation of mitotic sister chromatid separation (GO:0010965)2.88857848
94regulation of mitotic sister chromatid segregation (GO:0033047)2.88857848
95regulation of sister chromatid segregation (GO:0033045)2.88857848
96translational initiation (GO:0006413)2.88716865
97* chromatin assembly (GO:0031497)2.88333657
98RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88166573
99mRNA splicing, via spliceosome (GO:0000398)2.88166573
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87626004
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87626004
102RNA splicing, via transesterification reactions (GO:0000375)2.86901815
103formation of translation preinitiation complex (GO:0001731)2.86831720
104chromosome condensation (GO:0030261)2.85534345
105histone H3-K4 methylation (GO:0051568)2.84098909
106protein-DNA complex disassembly (GO:0032986)2.83979950
107nucleosome disassembly (GO:0006337)2.83979950
108spliceosomal tri-snRNP complex assembly (GO:0000244)2.82590655
109negative regulation of chromosome segregation (GO:0051985)2.81995879
110histone H2A monoubiquitination (GO:0035518)2.81718158
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81562688
112regulation of translation, ncRNA-mediated (GO:0045974)2.81317116
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81317116
114histone exchange (GO:0043486)2.79895280
115translesion synthesis (GO:0019985)2.77664684
116regulation of histone H3-K4 methylation (GO:0051569)2.76505612
117regulation of centriole replication (GO:0046599)2.76368703
118* chromosome segregation (GO:0007059)2.76254788
119histone mRNA catabolic process (GO:0071044)2.75871105
120positive regulation of histone H3-K4 methylation (GO:0051571)2.75795442
121* regulation of chromosome segregation (GO:0051983)2.75408112
122IMP biosynthetic process (GO:0006188)2.75312565
123ribosomal small subunit biogenesis (GO:0042274)2.74213514
124glucocorticoid receptor signaling pathway (GO:0042921)2.71867393
125termination of RNA polymerase II transcription (GO:0006369)2.71610994
126nuclear envelope organization (GO:0006998)2.70124968
127nuclear-transcribed mRNA catabolic process (GO:0000956)2.70032269
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.69828749
129spindle checkpoint (GO:0031577)2.69462735
130negative regulation of DNA-dependent DNA replication (GO:2000104)2.69257663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.08059930
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.30745771
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.66774219
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.44932066
5* MYC_22102868_ChIP-Seq_BL_Human3.25855237
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.10752973
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70717386
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47297526
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.44916789
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30372466
11CIITA_25753668_ChIP-Seq_RAJI_Human2.27354936
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.11449643
13AR_21909140_ChIP-Seq_LNCAP_Human2.10701431
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09337336
15E2F7_22180533_ChIP-Seq_HELA_Human10.7064275
16VDR_21846776_ChIP-Seq_THP-1_Human1.93035592
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87005703
18XRN2_22483619_ChIP-Seq_HELA_Human1.84680858
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83992376
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77531586
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76237837
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68858341
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.64588333
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62697518
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62339046
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60136609
27* VDR_23849224_ChIP-Seq_CD4+_Human1.59632720
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59599568
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59599568
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59599568
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58681036
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58526354
33FOXP3_21729870_ChIP-Seq_TREG_Human1.57251805
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51825769
35KDM5A_27292631_Chip-Seq_BREAST_Human1.51811994
36* TCF7_22412390_ChIP-Seq_EML_Mouse1.51587899
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.51572800
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48333786
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47447797
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45904107
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43286416
42UTX_26944678_Chip-Seq_JUKART_Human1.42808091
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40003990
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39129465
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.38001906
46TTF2_22483619_ChIP-Seq_HELA_Human1.37550999
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34621977
48ELK1_19687146_ChIP-ChIP_HELA_Human1.33716443
49MYB_26560356_Chip-Seq_TH2_Human1.31604911
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30959362
51MAF_26560356_Chip-Seq_TH1_Human1.29937926
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29403035
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29194938
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28398997
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28089608
56MYB_26560356_Chip-Seq_TH1_Human1.27973446
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27395931
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27160209
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27002616
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25848930
61* SCL_19346495_ChIP-Seq_HPC-7_Human1.25148579
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24318328
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23288658
64* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21743819
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21571127
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20931498
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20217712
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19819041
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17146479
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.16316460
71* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16155366
72GABP_19822575_ChIP-Seq_HepG2_Human1.14984597
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14778068
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14318656
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.13474599
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13409359
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11705078
78* SPI1_23547873_ChIP-Seq_NB4_Human1.09672950
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09622662
80DCP1A_22483619_ChIP-Seq_HELA_Human1.09479314
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09227822
82KDM2B_26808549_Chip-Seq_DND41_Human1.08456479
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08194337
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07324972
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06625369
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05768211
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05636868
88PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03827819
89CHD1_26751641_Chip-Seq_LNCaP_Human1.03430330
90* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02094806
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00876679
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99041289
93VDR_24763502_ChIP-Seq_THP-1_Human0.98703062
94THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97782027
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97402915
96TFEB_21752829_ChIP-Seq_HELA_Human0.97013294
97E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97002690
98SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96600320
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96527878
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95967125
101RUNX1_22412390_ChIP-Seq_EML_Mouse0.93262217
102* NCOR1_26117541_ChIP-Seq_K562_Human0.91936127
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.88823528
104MAF_26560356_Chip-Seq_TH2_Human0.88822895
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88275253
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88046456
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87938891
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87512553
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87499805
110BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87371711
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86171811
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85809123
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85736557
114TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84248922
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83478838
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.81817897
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81383950
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78405200
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.78141287
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75974918
121* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75679027
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75276246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.18720657
2MP0010094_abnormal_chromosome_stability4.03199043
3MP0003111_abnormal_nucleus_morphology3.81281893
4MP0003077_abnormal_cell_cycle3.51850156
5MP0004957_abnormal_blastocyst_morpholog3.44741269
6MP0008057_abnormal_DNA_replication3.39410406
7MP0002396_abnormal_hematopoietic_system2.80914374
8MP0010352_gastrointestinal_tract_polyps2.44276345
9MP0008007_abnormal_cellular_replicative2.37803573
10MP0004808_abnormal_hematopoietic_stem2.33097539
11MP0008058_abnormal_DNA_repair2.22439793
12MP0000350_abnormal_cell_proliferation2.18796712
13MP0001730_embryonic_growth_arrest2.17995396
14MP0005076_abnormal_cell_differentiation2.17392410
15MP0003763_abnormal_thymus_physiology2.03765772
16MP0003123_paternal_imprinting1.97134135
17MP0010307_abnormal_tumor_latency1.92192304
18* MP0000703_abnormal_thymus_morphology1.79972777
19MP0009278_abnormal_bone_marrow1.77686880
20MP0000490_abnormal_crypts_of1.77664932
21MP0001672_abnormal_embryogenesis/_devel1.75413180
22MP0005380_embryogenesis_phenotype1.75413180
23* MP0002398_abnormal_bone_marrow1.71241814
24MP0001697_abnormal_embryo_size1.68400863
25MP0003121_genomic_imprinting1.65834815
26MP0002084_abnormal_developmental_patter1.65512380
27MP0003984_embryonic_growth_retardation1.61816625
28MP0008877_abnormal_DNA_methylation1.61250800
29MP0002088_abnormal_embryonic_growth/wei1.60548872
30MP0002085_abnormal_embryonic_tissue1.58438353
31MP0004197_abnormal_fetal_growth/weight/1.57258980
32MP0002086_abnormal_extraembryonic_tissu1.56106797
33MP0008932_abnormal_embryonic_tissue1.55509492
34MP0003567_abnormal_fetal_cardiomyocyte1.55474034
35MP0004185_abnormal_adipocyte_glucose1.46627089
36* MP0002080_prenatal_lethality1.46553258
37MP0002019_abnormal_tumor_incidence1.45239676
38MP0003787_abnormal_imprinting1.44906271
39MP0005397_hematopoietic_system_phenotyp1.44193249
40MP0001545_abnormal_hematopoietic_system1.44193249
41* MP0002722_abnormal_immune_system1.37558430
42MP0006292_abnormal_olfactory_placode1.36764192
43MP0002089_abnormal_postnatal_growth/wei1.34985659
44MP0008995_early_reproductive_senescence1.34588917
45MP0000465_gastrointestinal_hemorrhage1.33606489
46MP0006054_spinal_hemorrhage1.32088937
47MP0002166_altered_tumor_susceptibility1.32020220
48MP0000313_abnormal_cell_death1.31409912
49MP0003890_abnormal_embryonic-extraembry1.30560700
50MP0005075_abnormal_melanosome_morpholog1.30358142
51MP0009333_abnormal_splenocyte_physiolog1.29948439
52MP0004381_abnormal_hair_follicle1.29186085
53MP0000569_abnormal_digit_pigmentation1.28792981
54MP0000689_abnormal_spleen_morphology1.28130057
55MP0001800_abnormal_humoral_immune1.27807352
56MP0002877_abnormal_melanocyte_morpholog1.22412563
57MP0003941_abnormal_skin_development1.18506998
58MP0000537_abnormal_urethra_morphology1.16672756
59* MP0000716_abnormal_immune_system1.16584954
60* MP0002429_abnormal_blood_cell1.14103910
61MP0001293_anophthalmia1.13079260
62MP0001849_ear_inflammation1.11599390
63MP0002006_tumorigenesis1.10369932
64MP0003300_gastrointestinal_ulcer1.06507220
65MP0005174_abnormal_tail_pigmentation1.06403160
66MP0010234_abnormal_vibrissa_follicle1.04397169
67MP0009672_abnormal_birth_weight1.03340244
68MP0001346_abnormal_lacrimal_gland1.02985550
69MP0009703_decreased_birth_body1.02961098
70MP0002420_abnormal_adaptive_immunity1.00941514
71MP0000685_abnormal_immune_system0.98672459
72MP0003786_premature_aging0.98081414
73MP0001819_abnormal_immune_cell0.97460513
74MP0009053_abnormal_anal_canal0.95677866
75MP0002092_abnormal_eye_morphology0.95453886
76MP0002452_abnormal_antigen_presenting0.95023277
77MP0002009_preneoplasia0.92747530
78MP0000733_abnormal_muscle_development0.92440824
79MP0000377_abnormal_hair_follicle0.91963413
80MP0009697_abnormal_copulation0.91060874
81MP0005671_abnormal_response_to0.90290489
82MP0003718_maternal_effect0.88828834
83MP0002925_abnormal_cardiovascular_devel0.88786985
84MP0003119_abnormal_digestive_system0.88105325
85MP0000428_abnormal_craniofacial_morphol0.87747769
86MP0003861_abnormal_nervous_system0.87560599
87MP0002210_abnormal_sex_determination0.87327691
88MP0000566_synostosis0.86842053
89MP0003705_abnormal_hypodermis_morpholog0.86473676
90MP0010030_abnormal_orbit_morphology0.85979490
91MP0003303_peritoneal_inflammation0.85296003
92MP0002796_impaired_skin_barrier0.84381423
93MP0002111_abnormal_tail_morphology0.84088075
94MP0004264_abnormal_extraembryonic_tissu0.83747410
95MP0003935_abnormal_craniofacial_develop0.82971044
96MP0005384_cellular_phenotype0.82764266
97MP0001286_abnormal_eye_development0.82550285
98MP0010155_abnormal_intestine_physiology0.81538579
99MP0005501_abnormal_skin_physiology0.79915483
100MP0002095_abnormal_skin_pigmentation0.78251735
101MP0003943_abnormal_hepatobiliary_system0.78059818
102MP0000477_abnormal_intestine_morphology0.77995315
103MP0002723_abnormal_immune_serum0.77677949
104MP0002405_respiratory_system_inflammati0.77631379
105MP0010630_abnormal_cardiac_muscle0.76695548
106MP0001145_abnormal_male_reproductive0.75827618
107MP0003937_abnormal_limbs/digits/tail_de0.75196104
108MP0001929_abnormal_gametogenesis0.74136235
109MP0001915_intracranial_hemorrhage0.73705188
110MP0008770_decreased_survivor_rate0.73512880
111MP0000432_abnormal_head_morphology0.73394273
112MP0003566_abnormal_cell_adhesion0.73297636
113MP0005387_immune_system_phenotype0.71785651
114MP0001790_abnormal_immune_system0.71785651
115MP0003656_abnormal_erythrocyte_physiolo0.71586655
116MP0001784_abnormal_fluid_regulation0.71073770
117MP0005451_abnormal_body_composition0.70021369
118MP0001835_abnormal_antigen_presentation0.69559136
119MP0005621_abnormal_cell_physiology0.69330208
120MP0003115_abnormal_respiratory_system0.68796513
121MP0000858_altered_metastatic_potential0.68655337
122MP0002697_abnormal_eye_size0.68124135
123MP0009780_abnormal_chondrocyte_physiolo0.68046440
124MP0003385_abnormal_body_wall0.67547814
125MP0002233_abnormal_nose_morphology0.67317572
126MP0003315_abnormal_perineum_morphology0.67280826
127MP0002081_perinatal_lethality0.65631715
128MP0003699_abnormal_female_reproductive0.64613299
129MP0000653_abnormal_sex_gland0.62071090
130MP0006035_abnormal_mitochondrial_morpho0.61208962
131MP0002163_abnormal_gland_morphology0.61108148
132MP0002114_abnormal_axial_skeleton0.60522081
133MP0002098_abnormal_vibrissa_morphology0.59159747

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.96358246
2Nephroblastoma (Wilms tumor) (HP:0002667)3.67533933
3Abnormality of the fingertips (HP:0001211)3.51898592
4Embryonal renal neoplasm (HP:0011794)3.49877197
5Colon cancer (HP:0003003)3.39655637
6Neoplasm of the adrenal cortex (HP:0100641)3.17773524
7Reticulocytopenia (HP:0001896)2.91568805
8Ependymoma (HP:0002888)2.85892902
9Short 4th metacarpal (HP:0010044)2.85194914
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.85194914
11Increased nuchal translucency (HP:0010880)2.84520326
12Recurrent viral infections (HP:0004429)2.79465582
13High anterior hairline (HP:0009890)2.75997788
14Birth length less than 3rd percentile (HP:0003561)2.74881351
15T lymphocytopenia (HP:0005403)2.73448797
16Basal cell carcinoma (HP:0002671)2.72481638
17Medulloblastoma (HP:0002885)2.68993151
18Abnormality of the left ventricular outflow tract (HP:0011103)2.65817656
19Subaortic stenosis (HP:0001682)2.65817656
20Chromsome breakage (HP:0040012)2.64388338
21Panhypogammaglobulinemia (HP:0003139)2.62551718
22IgM deficiency (HP:0002850)2.61088144
23Prominent nose (HP:0000448)2.59629589
24Progressive external ophthalmoplegia (HP:0000590)2.54728581
25Patellar aplasia (HP:0006443)2.54522139
26Abnormal number of incisors (HP:0011064)2.54088758
27Myelodysplasia (HP:0002863)2.51931178
28Abnormality of cells of the erythroid lineage (HP:0012130)2.51523691
29Papillary thyroid carcinoma (HP:0002895)2.51148880
30Abnormality of chromosome stability (HP:0003220)2.48886519
31Proximal placement of thumb (HP:0009623)2.46530957
32Abnormality of B cell number (HP:0010975)2.44372118
33B lymphocytopenia (HP:0010976)2.44372118
34Abnormality of T cell number (HP:0011839)2.44004986
35Abnormal hair whorl (HP:0010721)2.42998695
36Long eyelashes (HP:0000527)2.41060124
37Selective tooth agenesis (HP:0001592)2.40566777
38Asymmetry of the thorax (HP:0001555)2.40046359
39Facial hemangioma (HP:0000329)2.35882838
40Aplasia/Hypoplasia of the patella (HP:0006498)2.35615251
41Deviation of the thumb (HP:0009603)2.35453030
42Embryonal neoplasm (HP:0002898)2.35434202
43High pitched voice (HP:0001620)2.32767188
44Thyroiditis (HP:0100646)2.32547159
45Transitional cell carcinoma of the bladder (HP:0006740)2.32145424
46Thrombocytosis (HP:0001894)2.30847703
47Abnormal number of erythroid precursors (HP:0012131)2.30495415
48Absent radius (HP:0003974)2.29311607
49Cellulitis (HP:0100658)2.27595446
50Hepatoblastoma (HP:0002884)2.27112543
51Ectopic kidney (HP:0000086)2.26243197
52Rhabdomyosarcoma (HP:0002859)2.24862141
53Duplicated collecting system (HP:0000081)2.24580458
54Uterine leiomyosarcoma (HP:0002891)2.24361897
55Leiomyosarcoma (HP:0100243)2.24361897
56Duplication of thumb phalanx (HP:0009942)2.23317061
57Hyperacusis (HP:0010780)2.22273877
58Duodenal stenosis (HP:0100867)2.20603181
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20586832
60Urethral obstruction (HP:0000796)2.17576935
61Acute myeloid leukemia (HP:0004808)2.17400399
62Recurrent bronchitis (HP:0002837)2.17314797
63Agammaglobulinemia (HP:0004432)2.15945361
64Truncal obesity (HP:0001956)2.14196010
65Lymphoma (HP:0002665)2.13922618
66Neoplasm of the oral cavity (HP:0100649)2.13717253
67Abnormality of T cells (HP:0002843)2.12106692
68Abnormality of the labia minora (HP:0012880)2.09839661
69Acute lymphatic leukemia (HP:0006721)2.08271034
70Malignant gastrointestinal tract tumors (HP:0006749)2.05933290
71Gastrointestinal carcinoma (HP:0002672)2.05933290
72Absent forearm bone (HP:0003953)2.03836881
73Aplasia involving forearm bones (HP:0009822)2.03836881
74Cafe-au-lait spot (HP:0000957)2.02429876
75Papilloma (HP:0012740)2.01804141
76Verrucae (HP:0200043)2.01804141
77Bladder neoplasm (HP:0009725)2.01289157
78Bladder carcinoma (HP:0002862)2.01289157
79Choanal atresia (HP:0000453)2.01226075
80Combined immunodeficiency (HP:0005387)2.00352826
81Cutis marmorata (HP:0000965)1.99690992
82Biliary tract neoplasm (HP:0100574)1.99104872
83Atresia of the external auditory canal (HP:0000413)1.98296431
84Squamous cell carcinoma (HP:0002860)1.98072694
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96670304
86Vertebral arch anomaly (HP:0008438)1.96423308
87Neonatal hypoglycemia (HP:0001998)1.96255700
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.96142032
89Abnormality of the astrocytes (HP:0100707)1.94693377
90Astrocytoma (HP:0009592)1.94693377
91Aplastic anemia (HP:0001915)1.94589154
92Abnormality of the 4th metacarpal (HP:0010012)1.93272748
93Abnormality of the carotid arteries (HP:0005344)1.93238262
94Missing ribs (HP:0000921)1.93061163
95Abnormality of DNA repair (HP:0003254)1.93018695
96Abnormality of the preputium (HP:0100587)1.92580558
97Horseshoe kidney (HP:0000085)1.91123999
98Neoplasm of striated muscle (HP:0009728)1.90406633
99Meckel diverticulum (HP:0002245)1.90322326
100Severe combined immunodeficiency (HP:0004430)1.90180336
101Amaurosis fugax (HP:0100576)1.89286218
102Supernumerary ribs (HP:0005815)1.88585619
103Abnormality of the duodenum (HP:0002246)1.88405117
104Pallor (HP:0000980)1.88163229
105Neoplasm of the pancreas (HP:0002894)1.87375365
106Agnosia (HP:0010524)1.87352916
107Abnormality of cochlea (HP:0000375)1.87319659
108Increased density of long bones (HP:0006392)1.87269528
109Supernumerary bones of the axial skeleton (HP:0009144)1.86885061
110Absent thumb (HP:0009777)1.86323505
111Arteriovenous malformation (HP:0100026)1.85529691
112Deep philtrum (HP:0002002)1.85439622
113Ankyloglossia (HP:0010296)1.85172708
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.85105381
115Abnormality of the renal collecting system (HP:0004742)1.85089955
116Skin tags (HP:0010609)1.85010789
117Abnormality of the ileum (HP:0001549)1.82822373
118Diastasis recti (HP:0001540)1.82585620
119IgG deficiency (HP:0004315)1.82569278
120Thyroid carcinoma (HP:0002890)1.82540271
121Aplasia/Hypoplasia of the uvula (HP:0010293)1.82386926
122Cellular immunodeficiency (HP:0005374)1.81594886
123Intestinal fistula (HP:0100819)1.81364598
124Abnormality of the intervertebral disk (HP:0005108)1.80897355
125Broad palm (HP:0001169)1.80072144
126Sandal gap (HP:0001852)1.79930200
127Abnormality of chromosome segregation (HP:0002916)1.78597350
128Heterotopia (HP:0002282)1.77796975
129Abnormal lung lobation (HP:0002101)1.76649439
130Long clavicles (HP:0000890)1.76536354
131Recurrent fungal infections (HP:0002841)1.76233132
132Abnormal sex determination (HP:0012244)1.74785818
133Sex reversal (HP:0012245)1.74785818
134Triphalangeal thumb (HP:0001199)1.74472561
135Pancreatic islet-cell hyperplasia (HP:0004510)1.73885832
136Overlapping toe (HP:0001845)1.73067856
137Macrocytic anemia (HP:0001972)1.72684803
138Skull defect (HP:0001362)1.72290367
139Multiple enchondromatosis (HP:0005701)1.71267669
140Oral leukoplakia (HP:0002745)1.70874016
141Trigonocephaly (HP:0000243)1.70807686
142Rib fusion (HP:0000902)1.70751478
143Septate vagina (HP:0001153)1.70625319
14411 pairs of ribs (HP:0000878)1.69883990
145Supernumerary spleens (HP:0009799)1.69767549
146Macroorchidism (HP:0000053)1.69628626
147Hypoglycemic seizures (HP:0002173)1.69355861
148Sloping forehead (HP:0000340)1.68923025
149Obsessive-compulsive behavior (HP:0000722)1.68779116
150Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68511486
151Small intestinal stenosis (HP:0012848)1.68203742
152Abnormal foot bone ossification (HP:0010675)1.66333724
153Clubbing of toes (HP:0100760)1.66225799
154Rectovaginal fistula (HP:0000143)1.64983487
155Rectal fistula (HP:0100590)1.64983487
156Radioulnar synostosis (HP:0002974)1.62226881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.26272086
2MAP3K103.73464273
3SMG13.48899077
4CDK123.27406567
5EEF2K3.26700494
6NEK23.21379661
7TAF12.91839533
8WEE12.76133967
9TTK2.44765486
10MAP4K12.36085060
11VRK22.31178168
12STK102.05836248
13MKNK11.92575724
14BUB11.91285503
15PASK1.90463559
16RPS6KB21.87288326
17SRPK11.86323318
18MKNK21.86131131
19PKN21.82797390
20CDK41.81413195
21STK41.76347527
22DYRK31.68030999
23MAP3K91.67431341
24BRD41.64703304
25ATR1.63882426
26MST41.60889565
27RPS6KA41.59927826
28PRPF4B1.58404194
29AURKB1.57536241
30BRSK21.55893022
31GRK61.53572281
32CDK71.47220939
33CDK61.46761774
34CLK11.42643021
35ALK1.39341917
36PLK11.37239028
37CHEK21.36881585
38CHEK11.32555169
39LATS11.25587097
40MAP3K81.24770937
41TGFBR11.23860346
42TNIK1.23339839
43MELK1.22058255
44PLK31.19728061
45STK31.19585772
46TLK11.14878479
47TSSK61.14043810
48ATM1.13724006
49PIM11.10567327
50CDK21.03449273
51LRRK21.02662874
52CAMK1G1.02226105
53YES11.00196142
54VRK11.00075384
55ACVR1B0.96884377
56BTK0.91774790
57CDK90.90624892
58PLK40.90504381
59EIF2AK10.90029434
60FGFR40.86930429
61BRSK10.84645860
62PBK0.83913217
63TAOK30.82539333
64SCYL20.81678875
65NUAK10.81456983
66HIPK20.79782482
67EIF2AK20.79511408
68NEK10.78499593
69FGFR30.77906141
70TRIB30.76142234
71PAK40.75703130
72MTOR0.74730321
73CDK10.73589156
74STK240.70846883
75JAK30.70729304
76TXK0.70539681
77SIK20.69816598
78ICK0.64637810
79ITK0.63038337
80SYK0.61793488
81MAP3K20.60973016
82CDK80.59355796
83PTK60.59311119
84FLT30.57978076
85FRK0.54081233
86ZAP700.53901268
87NLK0.53690787
88CDK30.52991369
89CSNK1D0.52803871
90MAPK140.52541536
91AURKA0.52219822
92PDGFRB0.52036682
93PRKDC0.50154482
94FGFR10.49208995
95LCK0.48783598
96PNCK0.48646982
97SGK30.47648414
98CAMK1D0.47403165
99HCK0.46627605
100CSNK2A20.45458362
101TEC0.44726018
102CSF1R0.44648712
103DMPK0.44373987
104RPS6KB10.43726278
105FGFR20.43607298
106RPS6KA50.43578324
107CSNK1E0.42616921
108PDGFRA0.42454638
109CSNK1A1L0.41176570
110MAPKAPK50.40712992
111AKT10.39803206
112SIK10.39787156
113CHUK0.39419532
114SGK20.38753843
115TYRO30.38116279
116EIF2AK30.37746106
117TYK20.36645947
118MAPK10.35730099
119PAK20.34432829
120GSK3B0.34129979
121RPS6KA10.34073201
122CSK0.31237918
123TRIM280.31121474
124MAPK110.31073468
125BMX0.30844038
126CSNK2A10.29772981
127CDK11A0.29340405
128MARK30.29279823
129MAPK100.28886970
130AKT20.28515352
131TESK20.28511186
132BRAF0.27501605
133ZAK0.27007268
134CDK150.26876900
135CDK180.25797743

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.75372246
2Mismatch repair_Homo sapiens_hsa034303.40338072
3Spliceosome_Homo sapiens_hsa030403.06239798
4Cell cycle_Homo sapiens_hsa041102.82564554
5RNA transport_Homo sapiens_hsa030132.66109110
6Base excision repair_Homo sapiens_hsa034102.55484038
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39752002
8Non-homologous end-joining_Homo sapiens_hsa034502.32410015
9mRNA surveillance pathway_Homo sapiens_hsa030152.30781817
10Homologous recombination_Homo sapiens_hsa034402.29278398
11Ribosome_Homo sapiens_hsa030102.21391942
12Primary immunodeficiency_Homo sapiens_hsa053402.18924901
13Nucleotide excision repair_Homo sapiens_hsa034202.05628220
14Fanconi anemia pathway_Homo sapiens_hsa034601.96880972
15RNA degradation_Homo sapiens_hsa030181.89468819
16One carbon pool by folate_Homo sapiens_hsa006701.82549340
17Systemic lupus erythematosus_Homo sapiens_hsa053221.51685922
18p53 signaling pathway_Homo sapiens_hsa041151.51278033
19RNA polymerase_Homo sapiens_hsa030201.48450870
20MicroRNAs in cancer_Homo sapiens_hsa052061.42103466
21Antigen processing and presentation_Homo sapiens_hsa046121.41732498
22Viral carcinogenesis_Homo sapiens_hsa052031.41552061
23B cell receptor signaling pathway_Homo sapiens_hsa046621.38198574
24Herpes simplex infection_Homo sapiens_hsa051681.38196163
25Chronic myeloid leukemia_Homo sapiens_hsa052201.37337767
26Basal transcription factors_Homo sapiens_hsa030221.35301090
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32553365
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32358360
29HTLV-I infection_Homo sapiens_hsa051661.27705176
30Pyrimidine metabolism_Homo sapiens_hsa002401.27108642
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23664981
32Colorectal cancer_Homo sapiens_hsa052101.22165116
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14990704
34Small cell lung cancer_Homo sapiens_hsa052221.12399175
35Non-small cell lung cancer_Homo sapiens_hsa052231.10638513
36Epstein-Barr virus infection_Homo sapiens_hsa051691.09790456
37Thyroid cancer_Homo sapiens_hsa052161.08066755
38Oocyte meiosis_Homo sapiens_hsa041141.06921357
39T cell receptor signaling pathway_Homo sapiens_hsa046601.06448306
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.04605421
41Selenocompound metabolism_Homo sapiens_hsa004500.99244322
42Notch signaling pathway_Homo sapiens_hsa043300.97662226
43Hepatitis B_Homo sapiens_hsa051610.97202681
44Acute myeloid leukemia_Homo sapiens_hsa052210.92884231
45Pancreatic cancer_Homo sapiens_hsa052120.91885838
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89340257
47Prostate cancer_Homo sapiens_hsa052150.87152503
48Lysine degradation_Homo sapiens_hsa003100.87026186
49Measles_Homo sapiens_hsa051620.86942380
50Viral myocarditis_Homo sapiens_hsa054160.85373379
51mTOR signaling pathway_Homo sapiens_hsa041500.84579848
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84525760
53Basal cell carcinoma_Homo sapiens_hsa052170.83181691
54Endometrial cancer_Homo sapiens_hsa052130.81909744
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81630093
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81343582
57Alcoholism_Homo sapiens_hsa050340.81262851
58Hematopoietic cell lineage_Homo sapiens_hsa046400.80184290
59Adherens junction_Homo sapiens_hsa045200.80147806
60TGF-beta signaling pathway_Homo sapiens_hsa043500.78264281
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.76134334
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.74740814
63Hippo signaling pathway_Homo sapiens_hsa043900.71898009
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71216308
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71205428
66Pathways in cancer_Homo sapiens_hsa052000.70858824
67FoxO signaling pathway_Homo sapiens_hsa040680.69893694
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69761833
69Inositol phosphate metabolism_Homo sapiens_hsa005620.67078036
70Apoptosis_Homo sapiens_hsa042100.66883283
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65755067
72Wnt signaling pathway_Homo sapiens_hsa043100.63744413
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63089039
74ErbB signaling pathway_Homo sapiens_hsa040120.62949992
75Platelet activation_Homo sapiens_hsa046110.62942735
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61882089
77Proteoglycans in cancer_Homo sapiens_hsa052050.61731727
78Osteoclast differentiation_Homo sapiens_hsa043800.60934631
79Leishmaniasis_Homo sapiens_hsa051400.59781139
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.57315913
81Pentose phosphate pathway_Homo sapiens_hsa000300.56795569
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.56672689
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55005119
84Shigellosis_Homo sapiens_hsa051310.55002493
85Long-term potentiation_Homo sapiens_hsa047200.54212610
86Insulin signaling pathway_Homo sapiens_hsa049100.54150661
87Influenza A_Homo sapiens_hsa051640.53242009
88Purine metabolism_Homo sapiens_hsa002300.52366953
89Glioma_Homo sapiens_hsa052140.51472855
90Melanogenesis_Homo sapiens_hsa049160.50792748
91Toxoplasmosis_Homo sapiens_hsa051450.50737605
92Renal cell carcinoma_Homo sapiens_hsa052110.50114941
93Tight junction_Homo sapiens_hsa045300.49735423
94Biosynthesis of amino acids_Homo sapiens_hsa012300.48770274
95Bladder cancer_Homo sapiens_hsa052190.48554089
96Prolactin signaling pathway_Homo sapiens_hsa049170.47102594
97Hedgehog signaling pathway_Homo sapiens_hsa043400.46855280
98VEGF signaling pathway_Homo sapiens_hsa043700.45164442
99AMPK signaling pathway_Homo sapiens_hsa041520.43981765
100Proteasome_Homo sapiens_hsa030500.43974068
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43703355
102Glucagon signaling pathway_Homo sapiens_hsa049220.43368356
103Chemokine signaling pathway_Homo sapiens_hsa040620.42163671
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39444758
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36468594
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36182474
107Gap junction_Homo sapiens_hsa045400.35660231
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.35554642
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34826417
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34185458
111HIF-1 signaling pathway_Homo sapiens_hsa040660.33313852
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32502909
113Estrogen signaling pathway_Homo sapiens_hsa049150.32013312
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31498106
115Focal adhesion_Homo sapiens_hsa045100.31467052
116MAPK signaling pathway_Homo sapiens_hsa040100.31415225
117Melanoma_Homo sapiens_hsa052180.30617553
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.30195371
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30044135
120Choline metabolism in cancer_Homo sapiens_hsa052310.29981751
121Legionellosis_Homo sapiens_hsa051340.29945001
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29864839

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