CTBP2P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal-epithelial cell signaling (GO:0060638)9.14916534
2regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.92676954
3monoubiquitinated protein deubiquitination (GO:0035520)5.08048139
4bone trabecula formation (GO:0060346)4.80703733
5regulation of male gonad development (GO:2000018)4.68278105
6otic vesicle formation (GO:0030916)4.62464136
7positive regulation of male gonad development (GO:2000020)4.39017464
8branching involved in salivary gland morphogenesis (GO:0060445)4.38330514
9regulation of phospholipase A2 activity (GO:0032429)4.27230403
10mesenchymal cell proliferation (GO:0010463)3.99192056
11lateral sprouting from an epithelium (GO:0060601)3.94797872
12positive regulation of receptor internalization (GO:0002092)3.86670677
13protein localization to cell surface (GO:0034394)3.84761744
14GMP metabolic process (GO:0046037)3.63269452
15negative regulation of complement activation (GO:0045916)3.61768065
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.57009902
17mesonephros development (GO:0001823)3.49607735
18positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.49172538
19kidney mesenchyme development (GO:0072074)3.48224519
20metanephric mesenchyme development (GO:0072075)3.46107926
21water-soluble vitamin biosynthetic process (GO:0042364)3.45147878
22positive regulation of osteoblast proliferation (GO:0033690)3.41426589
23positive regulation of epidermal cell differentiation (GO:0045606)3.33455599
24regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.33173459
25trivalent inorganic anion homeostasis (GO:0072506)3.29720682
26phosphate ion homeostasis (GO:0055062)3.29720682
27pericardium development (GO:0060039)3.24738833
28branch elongation of an epithelium (GO:0060602)3.20840720
29auditory behavior (GO:0031223)3.12045164
30keratan sulfate catabolic process (GO:0042340)3.10756032
31collagen fibril organization (GO:0030199)3.10676965
32negative regulation of protein activation cascade (GO:2000258)3.07083421
33peptidyl-proline hydroxylation (GO:0019511)3.03687321
34negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.99530502
35lung secretory cell differentiation (GO:0061140)2.99267313
36glomerular visceral epithelial cell development (GO:0072015)2.98422270
37regulation of cholesterol esterification (GO:0010872)2.98108599
38limb bud formation (GO:0060174)2.97515782
39regulation of cell proliferation involved in kidney development (GO:1901722)2.97114016
40primary amino compound metabolic process (GO:1901160)2.96889846
41cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.95371499
42neuron projection extension involved in neuron projection guidance (GO:1902284)2.93912328
43axon extension involved in axon guidance (GO:0048846)2.93912328
44organ induction (GO:0001759)2.93529312
45regulation of fatty acid beta-oxidation (GO:0031998)2.91198672
46glomerular basement membrane development (GO:0032836)2.89903054
47protein prenylation (GO:0018342)2.89682043
48prenylation (GO:0097354)2.89682043
49dorsal/ventral axis specification (GO:0009950)2.87515663
50tooth mineralization (GO:0034505)2.85832567
51cell differentiation involved in metanephros development (GO:0072202)2.85065661
52chondrocyte development (GO:0002063)2.83025119
53white fat cell differentiation (GO:0050872)2.78369651
54regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.78205619
55vasculature development (GO:0001944)2.72539348
56serotonin metabolic process (GO:0042428)2.71869761
57nucleotide salvage (GO:0043173)2.71717560
58somite rostral/caudal axis specification (GO:0032525)2.71195741
59kidney morphogenesis (GO:0060993)2.70652901
60glomerular epithelial cell development (GO:0072310)2.69619839
61smooth muscle tissue development (GO:0048745)2.66897802
62phasic smooth muscle contraction (GO:0014821)2.65307311
63positive regulation of fatty acid beta-oxidation (GO:0032000)2.63860285
64face morphogenesis (GO:0060325)2.62942358
65nucleoside salvage (GO:0043174)2.62624581
66ureteric bud development (GO:0001657)2.62499836
67toxin metabolic process (GO:0009404)2.62176632
68non-canonical Wnt signaling pathway (GO:0035567)2.60663076
69pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.60425043
70UMP metabolic process (GO:0046049)2.60425043
71pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.60425043
72UMP biosynthetic process (GO:0006222)2.60425043
73negative regulation of axon extension involved in axon guidance (GO:0048843)2.59574496
74platelet-derived growth factor receptor signaling pathway (GO:0048008)2.58942056
75serotonin receptor signaling pathway (GO:0007210)2.57831954
76axis elongation (GO:0003401)2.56899000
77muscle cell fate commitment (GO:0042693)2.55948491
78regulation of hippo signaling (GO:0035330)2.55675281
79regulation of receptor internalization (GO:0002090)2.55245058
80decidualization (GO:0046697)2.54998721
81cranial suture morphogenesis (GO:0060363)2.54789525
82regulation of translation, ncRNA-mediated (GO:0045974)2.54765641
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54765641
84negative regulation of translation, ncRNA-mediated (GO:0040033)2.54765641
85mesonephric epithelium development (GO:0072163)2.54219350
86mesonephric tubule development (GO:0072164)2.53333789
87histone deubiquitination (GO:0016578)2.53168779
88bone remodeling (GO:0046849)2.52315994
89regulation of odontogenesis (GO:0042481)2.50503316
90adrenal gland development (GO:0030325)2.50092736
91negative regulation of humoral immune response (GO:0002921)2.48457072
92nodal signaling pathway (GO:0038092)2.45625857
93positive regulation of gastrulation (GO:2000543)2.45493309
94regulation of organ formation (GO:0003156)2.45266792
95protein hydroxylation (GO:0018126)2.44779907
96paraxial mesoderm development (GO:0048339)2.44415340
97response to hepatocyte growth factor (GO:0035728)2.44199424
98cellular response to hepatocyte growth factor stimulus (GO:0035729)2.44199424
99embryonic digestive tract morphogenesis (GO:0048557)2.42549609
100establishment of planar polarity (GO:0001736)2.42233485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.36758476
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse4.22734255
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52365306
4ZFP57_27257070_Chip-Seq_ESCs_Mouse3.02347391
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.00489521
6VDR_22108803_ChIP-Seq_LS180_Human2.88307224
7TAF15_26573619_Chip-Seq_HEK293_Human2.69702535
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57202272
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41251764
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.35199630
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.24789657
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.22169491
13TP53_16413492_ChIP-PET_HCT116_Human2.18482428
14GBX2_23144817_ChIP-Seq_PC3_Human2.13150802
15P300_19829295_ChIP-Seq_ESCs_Human2.09992643
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06702944
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.03629452
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94171906
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91735329
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.91735329
21TP53_18474530_ChIP-ChIP_U2OS_Human1.90172165
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85247353
23CJUN_26792858_Chip-Seq_BT549_Human1.84780858
24FUS_26573619_Chip-Seq_HEK293_Human1.84406787
25SMAD4_21799915_ChIP-Seq_A2780_Human1.83654020
26NR3C1_21868756_ChIP-Seq_MCF10A_Human1.83621902
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78591543
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72584200
29IRF1_19129219_ChIP-ChIP_H3396_Human1.69568518
30STAT3_23295773_ChIP-Seq_U87_Human1.68386938
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64355971
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.62592633
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62487581
34EWS_26573619_Chip-Seq_HEK293_Human1.61922646
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58550654
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56995249
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56975927
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56725498
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54276025
40ISL1_27105846_Chip-Seq_CPCs_Mouse1.53597250
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52749051
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49515910
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45987614
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.42783247
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41979424
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38686188
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37806758
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37806758
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.35274742
50TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31482430
51KDM2B_26808549_Chip-Seq_REH_Human1.30722443
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.30459673
53STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30097442
54ER_23166858_ChIP-Seq_MCF-7_Human1.29584418
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29365723
56TCF4_23295773_ChIP-Seq_U87_Human1.27928981
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27920397
58AHR_22903824_ChIP-Seq_MCF-7_Human1.27383518
59SMAD3_21741376_ChIP-Seq_HESCs_Human1.26438287
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25213115
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24937241
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.24215870
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24060256
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.23315180
65BRD4_25478319_ChIP-Seq_HGPS_Human1.23226232
66BCAT_22108803_ChIP-Seq_LS180_Human1.22599875
67AR_25329375_ChIP-Seq_VCAP_Human1.21285531
68ZNF274_21170338_ChIP-Seq_K562_Hela1.16608763
69SMAD4_21741376_ChIP-Seq_HESCs_Human1.15973497
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13300568
71LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13077428
72TBL1_22424771_ChIP-Seq_293T_Human1.12783513
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11718370
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10542550
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09874340
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.09488773
77TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09269692
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09093366
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09071416
80TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08344194
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07227851
82CBP_20019798_ChIP-Seq_JUKART_Human1.06906375
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06906375
84JUN_21703547_ChIP-Seq_K562_Human1.06205785
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05431901
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05005748
87RUNX2_22187159_ChIP-Seq_PCA_Human1.04167545
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03156166
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.02007692
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.01765687
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.01060610
92EED_16625203_ChIP-ChIP_MESCs_Mouse0.97866444
93AR_19668381_ChIP-Seq_PC3_Human0.97099141
94TP63_23658742_ChIP-Seq_EP156T_Human0.95177929
95CDX2_22108803_ChIP-Seq_LS180_Human0.94391224
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93734536
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93675850
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.91680791
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.88142820
100JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87857328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.85684688
2MP0005171_absent_coat_pigmentation3.88240804
3MP0010030_abnormal_orbit_morphology3.72731358
4MP0002102_abnormal_ear_morphology3.57586262
5MP0005275_abnormal_skin_tensile3.54727525
6MP0003136_yellow_coat_color3.00193875
7MP0009250_abnormal_appendicular_skeleto2.63606559
8MP0005248_abnormal_Harderian_gland2.62598653
9MP0003942_abnormal_urinary_system2.30489279
10MP0005508_abnormal_skeleton_morphology2.20027373
11MP0006072_abnormal_retinal_apoptosis2.19437078
12MP0000566_synostosis2.12528530
13MP0008438_abnormal_cutaneous_collagen2.02415913
14MP0001542_abnormal_bone_strength1.96268151
15MP0002282_abnormal_trachea_morphology1.89074674
16MP0002638_abnormal_pupillary_reflex1.88616821
17MP0002837_dystrophic_cardiac_calcinosis1.82316399
18MP0006054_spinal_hemorrhage1.81675280
19MP0003646_muscle_fatigue1.77692113
20MP0005257_abnormal_intraocular_pressure1.72389197
21MP0002938_white_spotting1.69145984
22MP0005253_abnormal_eye_physiology1.67656286
23MP0000049_abnormal_middle_ear1.65834396
24MP0006292_abnormal_olfactory_placode1.58288638
25MP0005595_abnormal_vascular_smooth1.56950345
26MP0000383_abnormal_hair_follicle1.55834926
27MP0003279_aneurysm1.52744002
28MP0003935_abnormal_craniofacial_develop1.49049232
29MP0002277_abnormal_respiratory_mucosa1.48109136
30MP0003937_abnormal_limbs/digits/tail_de1.47499148
31MP0003283_abnormal_digestive_organ1.44609943
32MP0008775_abnormal_heart_ventricle1.44486237
33MP0002108_abnormal_muscle_morphology1.41805399
34MP0003122_maternal_imprinting1.41475075
35MP0002295_abnormal_pulmonary_circulatio1.40417140
36MP0009697_abnormal_copulation1.37731809
37MP0000013_abnormal_adipose_tissue1.37439335
38MP0000537_abnormal_urethra_morphology1.34582548
39MP0001727_abnormal_embryo_implantation1.34280035
40MP0005076_abnormal_cell_differentiation1.28167117
41MP0004883_abnormal_blood_vessel1.27804835
42MP0001243_abnormal_dermal_layer1.26297419
43MP0002168_other_aberrant_phenotype1.25337479
44MP0001968_abnormal_touch/_nociception1.23373164
45MP0000428_abnormal_craniofacial_morphol1.22451927
46MP0003890_abnormal_embryonic-extraembry1.21264951
47MP0002928_abnormal_bile_duct1.20763536
48MP0000432_abnormal_head_morphology1.19509460
49MP0001286_abnormal_eye_development1.18909306
50MP0002233_abnormal_nose_morphology1.15791807
51MP0005377_hearing/vestibular/ear_phenot1.14840142
52MP0003878_abnormal_ear_physiology1.14840142
53MP0005023_abnormal_wound_healing1.14190208
54MP0003786_premature_aging1.13606050
55MP0010368_abnormal_lymphatic_system1.12646134
56MP0002697_abnormal_eye_size1.10146569
57MP0003938_abnormal_ear_development1.06575097
58MP0004272_abnormal_basement_membrane1.05680354
59MP0000163_abnormal_cartilage_morphology1.05101702
60MP0003011_delayed_dark_adaptation1.02511807
61MP0002653_abnormal_ependyma_morphology1.02457427
62MP0003755_abnormal_palate_morphology1.02372882
63MP0000762_abnormal_tongue_morphology1.00918188
64MP0003121_genomic_imprinting1.00135472
65MP0002115_abnormal_skeleton_extremities0.99946156
66MP0003119_abnormal_digestive_system0.99294310
67MP0000427_abnormal_hair_cycle0.97020370
68MP0002736_abnormal_nociception_after0.96193009
69MP0002932_abnormal_joint_morphology0.95605902
70MP0000681_abnormal_thyroid_gland0.94842737
71MP0000462_abnormal_digestive_system0.94511286
72MP0010678_abnormal_skin_adnexa0.94194635
73MP0005174_abnormal_tail_pigmentation0.93759967
74MP0002109_abnormal_limb_morphology0.92859455
75MP0001324_abnormal_eye_pigmentation0.91285280
76MP0003943_abnormal_hepatobiliary_system0.88846393
77MP0005391_vision/eye_phenotype0.85321262
78MP0000534_abnormal_ureter_morphology0.82887235
79MP0005164_abnormal_response_to0.81358190
80MP0004133_heterotaxia0.80980760
81MP0003091_abnormal_cell_migration0.80619140
82MP0002132_abnormal_respiratory_system0.80420941
83MP0002249_abnormal_larynx_morphology0.80357965
84MP0003123_paternal_imprinting0.79117071
85MP0001485_abnormal_pinna_reflex0.77305875
86MP0001958_emphysema0.76711874
87MP0000631_abnormal_neuroendocrine_gland0.75719344
88MP0001299_abnormal_eye_distance/0.75315190
89MP0000613_abnormal_salivary_gland0.75105634
90MP0003115_abnormal_respiratory_system0.75067754
91MP0000003_abnormal_adipose_tissue0.73199539
92MP0000358_abnormal_cell_content/0.71357902
93MP0001879_abnormal_lymphatic_vessel0.70845647
94MP0000230_abnormal_systemic_arterial0.70511643
95MP0002116_abnormal_craniofacial_bone0.70424827
96MP0000778_abnormal_nervous_system0.69248435
97MP0002114_abnormal_axial_skeleton0.68005957
98MP0005390_skeleton_phenotype0.67417816
99MP0001270_distended_abdomen0.62507661
100MP0002735_abnormal_chemical_nociception0.61541166

Predicted human phenotypes

RankGene SetZ-score
1Absent frontal sinuses (HP:0002688)6.05724896
2Subacute progressive viral hepatitis (HP:0006572)4.84861610
3Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.55207212
4Aplasia involving bones of the upper limbs (HP:0009823)3.95565831
5Aplasia of the phalanges of the hand (HP:0009802)3.95565831
6Aplasia involving bones of the extremities (HP:0009825)3.95565831
7Abnormality of the frontal sinuses (HP:0002687)3.79624228
8Cutaneous melanoma (HP:0012056)3.78284645
9Metaphyseal dysplasia (HP:0100255)3.65376461
10Abnormality of the phalanges of the 2nd finger (HP:0009541)3.62955801
11Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.45626099
12Partial duplication of the phalanx of hand (HP:0009999)3.37722267
13Partial duplication of thumb phalanx (HP:0009944)3.37594162
14Hyperglycinemia (HP:0002154)3.37034801
15Aplasia/Hypoplasia of the tibia (HP:0005772)3.35395891
16Short tibia (HP:0005736)3.30976562
17Broad metatarsal (HP:0001783)3.27740302
18Pigmentary retinal degeneration (HP:0001146)3.11227515
19Preaxial foot polydactyly (HP:0001841)2.93741199
20Choroideremia (HP:0001139)2.90185936
21Spondylolisthesis (HP:0003302)2.85456164
22Abnormality of incisor morphology (HP:0011063)2.85235418
23Fibular hypoplasia (HP:0003038)2.78607932
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75546709
25Mild short stature (HP:0003502)2.68804829
26Micronodular cirrhosis (HP:0001413)2.67553161
27True hermaphroditism (HP:0010459)2.66837370
28Facial shape deformation (HP:0011334)2.65715129
29Potter facies (HP:0002009)2.65715129
30Ulnar bowing (HP:0003031)2.61236936
31Bell-shaped thorax (HP:0001591)2.60557520
32Abnormality of the ischium (HP:0003174)2.60191650
33Premature rupture of membranes (HP:0001788)2.58755653
34Methylmalonic aciduria (HP:0012120)2.47842162
35Short hallux (HP:0010109)2.43956363
36Increased corneal curvature (HP:0100692)2.37517524
37Keratoconus (HP:0000563)2.37517524
38Large for gestational age (HP:0001520)2.35129845
39Methylmalonic acidemia (HP:0002912)2.32488789
40Viral hepatitis (HP:0006562)2.31592524
41Aplasia/Hypoplasia of the fibula (HP:0006492)2.29616693
42Abnormality of the 2nd finger (HP:0004100)2.28068869
43Duplication of thumb phalanx (HP:0009942)2.27402608
44Delayed closure of the anterior fontanelle (HP:0001476)2.26449431
45Congenital, generalized hypertrichosis (HP:0004540)2.25965835
46Osteolytic defects of the hand bones (HP:0009699)2.23742572
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.23742572
48Widely patent fontanelles and sutures (HP:0004492)2.22917216
49Wide anterior fontanel (HP:0000260)2.20894838
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.20033203
51Narrow palate (HP:0000189)2.15144160
52Decreased lacrimation (HP:0000633)2.13372463
53Cerebellar dysplasia (HP:0007033)2.12402286
54Hypoplastic ischia (HP:0003175)2.11615274
55Abnormal sex determination (HP:0012244)2.11408028
56Sex reversal (HP:0012245)2.11408028
57Arthropathy (HP:0003040)2.09279699
58Short middle phalanx of finger (HP:0005819)2.08917130
59Persistence of primary teeth (HP:0006335)2.08047514
60Decreased skull ossification (HP:0004331)2.07150309
61Abnormality of the parietal bone (HP:0002696)2.02759589
62Peritonitis (HP:0002586)2.01908176
63Delayed cranial suture closure (HP:0000270)2.01292811
64Syringomyelia (HP:0003396)1.99276655
65Spinal cord lesions (HP:0100561)1.99276655
66Irregular vertebral endplates (HP:0003301)1.97301051
67Abnormality of skull ossification (HP:0002703)1.96579157
68Vitreoretinal degeneration (HP:0000655)1.95986229
69Asymmetry of the thorax (HP:0001555)1.95790189
70Transitional cell carcinoma of the bladder (HP:0006740)1.93406473
71Femoral bowing (HP:0002980)1.91952094
72Coronal craniosynostosis (HP:0004440)1.90870227
73Bladder neoplasm (HP:0009725)1.90724095
74Bladder carcinoma (HP:0002862)1.90724095
75Meningioma (HP:0002858)1.89569692
76Missing ribs (HP:0000921)1.88714706
77Radial bowing (HP:0002986)1.86140503
78Bifid tongue (HP:0010297)1.85144497
79Wormian bones (HP:0002645)1.84264953
80Patent foramen ovale (HP:0001655)1.83245093
81Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.83170238
82Septo-optic dysplasia (HP:0100842)1.82743849
83Hepatocellular carcinoma (HP:0001402)1.82017450
84Megalencephaly (HP:0001355)1.81215949
85Type II lissencephaly (HP:0007260)1.80365375
86Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.77544718
87Limited hip movement (HP:0008800)1.76486816
88Alacrima (HP:0000522)1.76199303
89Hyperinsulinemic hypoglycemia (HP:0000825)1.75866689
90Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75396272
91Abnormality of the middle phalanges of the hand (HP:0009833)1.73847738
92Metaphyseal cupping (HP:0003021)1.71811254
93Nephronophthisis (HP:0000090)1.71286139
94Molar tooth sign on MRI (HP:0002419)1.69625740
95Abnormality of midbrain morphology (HP:0002418)1.69625740
96Bowing of the arm (HP:0006488)1.69079388
97Bowed forearm bones (HP:0003956)1.69079388
98Short nail (HP:0001799)1.68644168
99Hypoplastic pelvis (HP:0008839)1.65274641
100Rhinitis (HP:0012384)1.65059975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.87460873
2FGFR23.71418272
3BMPR1B3.47695613
4ACVR1B3.08663769
5CASK2.82712794
6MKNK22.38458197
7NLK2.28631071
8TNIK2.24072435
9WEE11.92779605
10NEK91.76786235
11BRSK21.70999530
12MAP2K41.62054765
13CSNK1G11.60663581
14TYRO31.58305905
15MAP3K61.57865336
16STK38L1.57529765
17TIE11.53997921
18INSRR1.48435315
19IRAK11.43549430
20TGFBR11.42544689
21MAP3K71.38288385
22PDK21.37102508
23WNK31.36839649
24AKT31.34240685
25CAMK1G1.30473540
26PIM21.26808141
27ERBB21.23061841
28GSK3A1.21528539
29STK391.18458209
30EPHA21.18024277
31PIK3CG1.16621175
32NME11.15206002
33OXSR11.11711720
34MKNK11.11238235
35RAF11.08423193
36PDGFRB1.08120548
37PRKAA21.06764898
38PTK2B1.05499489
39MAP3K41.04221876
40MAP3K131.03710955
41STK31.01619695
42SGK21.01248290
43CSNK1G30.98493219
44MAP2K70.97474154
45ZAK0.96372970
46PRKCE0.94895403
47NUAK10.92347899
48TLK10.90910802
49PLK40.90449283
50ADRBK10.89759535
51PLK20.85572758
52FGFR10.83566293
53DMPK0.82853770
54MAP3K110.81010230
55PNCK0.78525279
56CSNK1G20.78236905
57EPHB10.78054570
58SGK30.76303833
59PAK20.75884178
60EPHB20.74989333
61STK380.74730923
62SGK4940.73541195
63SGK2230.73541195
64CAMK1D0.73426943
65PLK30.72541349
66MELK0.67756473
67MARK20.67736065
68STK110.67359247
69CSNK1A1L0.63470389
70IRAK20.61573165
71VRK10.60464562
72TRPM70.57736981
73NTRK10.56922011
74MAPK70.53395844
75WNK40.51896121
76STK40.50442080
77ROCK10.49941096
78CAMK10.49923851
79NEK60.48636148
80CHUK0.47752973
81PLK10.47699353
82MTOR0.47699172
83BRD40.46409040
84MAPK150.45686485
85FER0.43867932
86PTK20.43333134
87SGK10.42876844
88ADRBK20.41362659
89DYRK1A0.39375700
90PTK60.39067002
91CAMK40.38534247
92CAMK2D0.37103129
93MST40.36285949
94DAPK20.34812943
95PAK30.34721669
96FGFR30.31811923
97ATM0.31347629
98LRRK20.29870259
99DYRK30.29598281
100PDGFRA0.28830076

Predicted pathways (KEGG)

RankGene SetZ-score
1Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.35772852
2Basal cell carcinoma_Homo sapiens_hsa052172.84035052
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.29508967
4ECM-receptor interaction_Homo sapiens_hsa045122.08572291
5Hedgehog signaling pathway_Homo sapiens_hsa043402.04709512
6Hippo signaling pathway_Homo sapiens_hsa043902.00696808
7Melanoma_Homo sapiens_hsa052181.97888094
8Type II diabetes mellitus_Homo sapiens_hsa049301.95900475
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.95805090
10TGF-beta signaling pathway_Homo sapiens_hsa043501.91628000
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.72725557
12Homologous recombination_Homo sapiens_hsa034401.70124059
13Fanconi anemia pathway_Homo sapiens_hsa034601.61425297
14ABC transporters_Homo sapiens_hsa020101.53493495
15Wnt signaling pathway_Homo sapiens_hsa043101.49136291
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46785590
17Taste transduction_Homo sapiens_hsa047421.46168959
18Sulfur metabolism_Homo sapiens_hsa009201.44413622
19Renin-angiotensin system_Homo sapiens_hsa046141.41688006
20Propanoate metabolism_Homo sapiens_hsa006401.39654886
21Dorso-ventral axis formation_Homo sapiens_hsa043201.29999419
22Folate biosynthesis_Homo sapiens_hsa007901.26989149
23Proteoglycans in cancer_Homo sapiens_hsa052051.25097583
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21390450
25Tryptophan metabolism_Homo sapiens_hsa003801.21331788
26Serotonergic synapse_Homo sapiens_hsa047261.21067965
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17986944
28Protein digestion and absorption_Homo sapiens_hsa049741.17395095
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15883132
30Melanogenesis_Homo sapiens_hsa049161.13020429
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11675478
32FoxO signaling pathway_Homo sapiens_hsa040681.11296170
33Butanoate metabolism_Homo sapiens_hsa006501.08639268
34Focal adhesion_Homo sapiens_hsa045101.07727961
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06793320
36Pathways in cancer_Homo sapiens_hsa052001.06504892
37Vitamin B6 metabolism_Homo sapiens_hsa007501.06435545
38Lysine degradation_Homo sapiens_hsa003101.05569347
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04015978
40p53 signaling pathway_Homo sapiens_hsa041151.00340968
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00210487
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00200535
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97987402
44Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97063612
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96932671
46Adherens junction_Homo sapiens_hsa045200.96921364
47Arginine and proline metabolism_Homo sapiens_hsa003300.92504800
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88446269
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85456943
50Prostate cancer_Homo sapiens_hsa052150.83532433
51Rap1 signaling pathway_Homo sapiens_hsa040150.81817668
52MicroRNAs in cancer_Homo sapiens_hsa052060.81644448
53Endometrial cancer_Homo sapiens_hsa052130.79285057
54Insulin secretion_Homo sapiens_hsa049110.78880955
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77241863
56AMPK signaling pathway_Homo sapiens_hsa041520.77179011
57Axon guidance_Homo sapiens_hsa043600.72975141
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.69716421
59Insulin resistance_Homo sapiens_hsa049310.69270341
60RNA polymerase_Homo sapiens_hsa030200.69160209
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68353158
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68020272
63Peroxisome_Homo sapiens_hsa041460.67003003
64Ras signaling pathway_Homo sapiens_hsa040140.65702183
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63788070
66Small cell lung cancer_Homo sapiens_hsa052220.62769439
67Gap junction_Homo sapiens_hsa045400.59815306
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58186838
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.58129339
70Dilated cardiomyopathy_Homo sapiens_hsa054140.58085502
71cAMP signaling pathway_Homo sapiens_hsa040240.57897367
72Oxidative phosphorylation_Homo sapiens_hsa001900.56058238
73Circadian rhythm_Homo sapiens_hsa047100.55891202
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55693661
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55493646
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53385215
77Malaria_Homo sapiens_hsa051440.53229896
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.52784458
79Mismatch repair_Homo sapiens_hsa034300.52095852
80Nucleotide excision repair_Homo sapiens_hsa034200.52086068
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50688141
82Calcium signaling pathway_Homo sapiens_hsa040200.49864820
83Renin secretion_Homo sapiens_hsa049240.48309949
84Colorectal cancer_Homo sapiens_hsa052100.47694594
85Glycerolipid metabolism_Homo sapiens_hsa005610.46187595
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.45697126
87Regulation of autophagy_Homo sapiens_hsa041400.45472703
88Cholinergic synapse_Homo sapiens_hsa047250.45311453
89Huntingtons disease_Homo sapiens_hsa050160.44212558
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43495465
91Olfactory transduction_Homo sapiens_hsa047400.43049899
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42278297
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41846622
94RNA degradation_Homo sapiens_hsa030180.41801358
95Sulfur relay system_Homo sapiens_hsa041220.41605851
96Cardiac muscle contraction_Homo sapiens_hsa042600.39838119
97Mineral absorption_Homo sapiens_hsa049780.38313322
98beta-Alanine metabolism_Homo sapiens_hsa004100.36809800
99Tight junction_Homo sapiens_hsa045300.36633231
100mTOR signaling pathway_Homo sapiens_hsa041500.34198422

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