CTBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-lysine dimethylation (GO:0018027)4.45221293
2negative regulation of cell size (GO:0045792)4.36579878
3mannose metabolic process (GO:0006013)4.14095194
4negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.09465075
5cytoskeletal anchoring at plasma membrane (GO:0007016)3.98732245
6negative regulation of erythrocyte differentiation (GO:0045647)3.93994896
7synaptic vesicle docking involved in exocytosis (GO:0016081)3.73837308
8peptidyl-tyrosine autophosphorylation (GO:0038083)3.72189892
9thymic T cell selection (GO:0045061)3.63958379
10maternal placenta development (GO:0001893)3.63516347
11layer formation in cerebral cortex (GO:0021819)3.62577765
12positive regulation of synapse maturation (GO:0090129)3.57483984
13sodium ion export (GO:0071436)3.53817578
14plasma membrane repair (GO:0001778)3.45202884
15Golgi transport vesicle coating (GO:0048200)3.42635842
16COPI coating of Golgi vesicle (GO:0048205)3.42635842
17activation of Rac GTPase activity (GO:0032863)3.37851993
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.36701342
19regulation of extracellular matrix disassembly (GO:0010715)3.32966427
20negative regulation of microtubule polymerization (GO:0031115)3.26369640
21regulation of synapse maturation (GO:0090128)3.25067936
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19702465
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19702465
24barbed-end actin filament capping (GO:0051016)3.19327511
25synaptic vesicle exocytosis (GO:0016079)3.18292127
26synaptic vesicle maturation (GO:0016188)3.14265870
27regulation of translational termination (GO:0006449)3.13970193
28stress fiber assembly (GO:0043149)3.10522708
29negative regulation of RNA splicing (GO:0033119)3.10464654
30regulation of ARF GTPase activity (GO:0032312)3.09841348
31pentose-phosphate shunt (GO:0006098)3.08070809
32DNA unwinding involved in DNA replication (GO:0006268)3.07860852
33regulation of early endosome to late endosome transport (GO:2000641)3.06675270
34activation of protein kinase A activity (GO:0034199)3.06086993
35establishment of nucleus localization (GO:0040023)3.02529397
36negative regulation of fatty acid transport (GO:2000192)2.99749210
37natural killer cell differentiation (GO:0001779)2.97066559
38glucocorticoid receptor signaling pathway (GO:0042921)2.96298342
39regulation of translational fidelity (GO:0006450)2.95777983
40peptidyl-arginine omega-N-methylation (GO:0035247)2.95047976
41dopamine receptor signaling pathway (GO:0007212)2.94673856
42myelin maintenance (GO:0043217)2.94069053
43cortical actin cytoskeleton organization (GO:0030866)2.93766215
44positive regulation of nuclease activity (GO:0032075)2.93116084
45apoptotic process involved in morphogenesis (GO:0060561)2.92788944
46G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91847263
47activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.90298111
48glutamate secretion (GO:0014047)2.89359516
49positive regulation of lamellipodium assembly (GO:0010592)2.89336187
50cell communication by electrical coupling (GO:0010644)2.89212384
51T cell selection (GO:0045058)2.88898326
52signal complex assembly (GO:0007172)2.85958675
53positive regulation of protein dephosphorylation (GO:0035307)2.84981347
54epithelial cell differentiation involved in prostate gland development (GO:0060742)2.83485138
55locomotory exploration behavior (GO:0035641)2.83396144
56glial cell proliferation (GO:0014009)2.81963563
57neuronal ion channel clustering (GO:0045161)2.81434711
58regulation of gamma-delta T cell differentiation (GO:0045586)2.80645049
59negative regulation of viral release from host cell (GO:1902187)2.79971924
60positive T cell selection (GO:0043368)2.79655479
61negative regulation of nucleotide catabolic process (GO:0030812)2.79585902
62peptidyl-arginine methylation (GO:0018216)2.79266368
63peptidyl-arginine N-methylation (GO:0035246)2.79266368
64regulation of fatty acid beta-oxidation (GO:0031998)2.78996421
65negative regulation of cAMP-mediated signaling (GO:0043951)2.77177048
66regulation of synapse structural plasticity (GO:0051823)2.76873931
67cerebellar Purkinje cell layer development (GO:0021680)2.75095573
68regulation of ARF protein signal transduction (GO:0032012)2.74455199
69protein localization to endosome (GO:0036010)2.72771997
70antigen processing and presentation via MHC class Ib (GO:0002475)2.71124450
71negative regulation of potassium ion transmembrane transport (GO:1901380)2.68804989
72positive regulation of lamellipodium organization (GO:1902745)2.67664527
73positive regulation of RNA splicing (GO:0033120)2.66863905
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66283672
75antigen processing and presentation of endogenous antigen (GO:0019883)2.65885178
76positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65035957
77adherens junction assembly (GO:0034333)2.64826314
78clathrin coat assembly (GO:0048268)2.64805738
79dosage compensation (GO:0007549)2.64244577
80regulation of glucose import in response to insulin stimulus (GO:2001273)2.63666454
81positive regulation of CREB transcription factor activity (GO:0032793)2.63642923
82mesenchymal cell differentiation involved in renal system development (GO:2001012)2.63089652
83mesenchymal cell differentiation involved in kidney development (GO:0072161)2.63089652
84protein-DNA complex disassembly (GO:0032986)2.62764475
85nucleosome disassembly (GO:0006337)2.62764475
86positive thymic T cell selection (GO:0045059)2.62415142
87cerebellar granule cell differentiation (GO:0021707)2.62270500
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61280034
89mitotic G1 DNA damage checkpoint (GO:0031571)2.59688035
90N-glycan processing (GO:0006491)2.59503635
91receptor catabolic process (GO:0032801)2.59185477
92cell migration in hindbrain (GO:0021535)2.59070071
93regulation of nuclease activity (GO:0032069)2.58984262
94NADPH regeneration (GO:0006740)2.58671315
95regulation of chromatin binding (GO:0035561)2.56724420
96cell-cell junction maintenance (GO:0045217)2.56250231
97negative regulation of glial cell proliferation (GO:0060253)2.54850974
98regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.54799929
99negative regulation of cardiac muscle tissue growth (GO:0055022)2.53940237
100negative regulation of heart growth (GO:0061117)2.53940237
101epithelial cell fate commitment (GO:0072148)2.53422324
102negative regulation of phagocytosis (GO:0050765)2.53334225
103activation of JUN kinase activity (GO:0007257)2.53205850
1043-UTR-mediated mRNA stabilization (GO:0070935)2.51027404
105negative regulation of mRNA processing (GO:0050686)2.49982919
106positive regulation of Rap GTPase activity (GO:0032854)2.49955050
107positive regulation of gamma-delta T cell activation (GO:0046645)2.49788160
108positive regulation of Rac GTPase activity (GO:0032855)2.48482316
109localization within membrane (GO:0051668)2.47030789
110* positive regulation of protein deacetylation (GO:0090312)2.46392629
111RNA stabilization (GO:0043489)2.43456638
112mRNA stabilization (GO:0048255)2.43456638
113morphogenesis of an endothelium (GO:0003159)2.42421640
114endothelial tube morphogenesis (GO:0061154)2.42421640
115insulin-like growth factor receptor signaling pathway (GO:0048009)2.41976556
116positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41619399
117cellular response to epidermal growth factor stimulus (GO:0071364)2.41591965
118positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40941754
119negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.40157504
120regulation of defense response to virus by virus (GO:0050690)2.38517501
121negative regulation of purine nucleotide catabolic process (GO:0033122)2.38271739
122positive regulation of receptor recycling (GO:0001921)2.37729632
123regulation of NFAT protein import into nucleus (GO:0051532)2.37421010
124negative regulation of mRNA metabolic process (GO:1903312)2.37357557
125corticosteroid receptor signaling pathway (GO:0031958)2.36303567
126* regulation of histone deacetylation (GO:0031063)2.35861980
127regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.35373555
128negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.35197604
129negative regulation of cell killing (GO:0031342)2.35197604
130membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34357184
131* positive regulation of histone deacetylation (GO:0031065)2.34293885
132positive regulation of Cdc42 GTPase activity (GO:0043089)2.33871021
133regulation of erythrocyte differentiation (GO:0045646)2.33698522
134cortical cytoskeleton organization (GO:0030865)2.33106443
135regulation of Rap GTPase activity (GO:0032317)2.33069345
136ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.32396848
137cell volume homeostasis (GO:0006884)2.32064157
138intracellular estrogen receptor signaling pathway (GO:0030520)2.30643067
139retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.30404241
140regulation of protein dephosphorylation (GO:0035304)2.30342600
141platelet formation (GO:0030220)2.29837406
142protein targeting to plasma membrane (GO:0072661)2.29817462
143positive regulation of glycogen biosynthetic process (GO:0045725)2.29079234
144negative thymic T cell selection (GO:0045060)2.28429510
145semaphorin-plexin signaling pathway (GO:0071526)2.28347690
146endoplasmic reticulum unfolded protein response (GO:0030968)2.28046613
147embryonic foregut morphogenesis (GO:0048617)2.27702624
148osteoblast development (GO:0002076)2.25848107
149positive regulation of nitric-oxide synthase activity (GO:0051000)2.25146642
150activation of MAPKKK activity (GO:0000185)2.24688974
151adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.24104733
152negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.23965005
153histone H3 deacetylation (GO:0070932)2.21107752
154response to parathyroid hormone (GO:0071107)2.18273827
155Rho protein signal transduction (GO:0007266)2.17845665
156regulation of viral release from host cell (GO:1902186)2.15711922
157negative T cell selection (GO:0043383)2.14802982
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.14033617
159neurotransmitter secretion (GO:0007269)2.13148849
160dendritic spine morphogenesis (GO:0060997)2.13010704
161antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.12600405
162positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.11443043
163neural tube development (GO:0021915)2.10234604
164entrainment of circadian clock by photoperiod (GO:0043153)2.09380165
165apoptotic process involved in development (GO:1902742)2.08624299
166vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.08510923
167cell junction maintenance (GO:0034331)2.06139623
168positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.05523562
169cellular response to catecholamine stimulus (GO:0071870)2.04938833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.96021474
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27460872
3VDR_21846776_ChIP-Seq_THP-1_Human3.10272960
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.91383039
5KDM2B_26808549_Chip-Seq_DND41_Human2.90492625
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.86040944
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80650097
8TCF7_22412390_ChIP-Seq_EML_Mouse2.62340631
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.57487805
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.46354477
11LXR_22292898_ChIP-Seq_THP-1_Human2.44530206
12* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.40577092
13ZNF263_19887448_ChIP-Seq_K562_Human2.36655353
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.28806698
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.21418207
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19297397
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17951538
18E2F7_22180533_ChIP-Seq_HELA_Human2.16261600
19KDM2B_26808549_Chip-Seq_JURKAT_Human2.00666253
20MAF_26560356_Chip-Seq_TH1_Human1.97220630
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94617365
22UTX_26944678_Chip-Seq_JUKART_Human1.94596017
23KDM2B_26808549_Chip-Seq_K562_Human1.91715357
24DROSHA_22980978_ChIP-Seq_HELA_Human1.90874586
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.88693047
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.87813127
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.79618489
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.75863736
29* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.73484406
30* VDR_24763502_ChIP-Seq_THP-1_Human1.71934213
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71603869
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70510266
33P300_27058665_Chip-Seq_ZR-75-30cells_Human1.70440632
34* RACK7_27058665_Chip-Seq_MCF-7_Human1.69790680
35CTCF_27219007_Chip-Seq_Bcells_Human1.68138661
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68022799
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66675811
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65816637
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64400261
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64010154
41CIITA_25753668_ChIP-Seq_RAJI_Human1.61982162
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60230289
43SCL_19346495_ChIP-Seq_HPC-7_Human1.57888888
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56578481
45CLOCK_20551151_ChIP-Seq_293T_Human1.55854061
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53245270
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53206209
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53037308
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52944523
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50430605
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49191597
52CREB1_26743006_Chip-Seq_LNCaP_Human1.46920268
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45813899
54* P68_20966046_ChIP-Seq_HELA_Human1.45288568
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44444382
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43673747
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43649969
58ATF3_27146783_Chip-Seq_COLON_Human1.43359245
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41956838
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41366748
61SPI1_23127762_ChIP-Seq_K562_Human1.38932644
62GATA1_19941826_ChIP-Seq_K562_Human1.35723871
63MAF_26560356_Chip-Seq_TH2_Human1.34696659
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33107112
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.31774355
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31159811
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30472260
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30342511
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29669088
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28253370
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27927081
72* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.27783281
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26036055
74NCOR1_26117541_ChIP-Seq_K562_Human1.25721660
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25539340
76* GATA1_19941827_ChIP-Seq_MEL_Mouse1.25273366
77* ELF1_20517297_ChIP-Seq_JURKAT_Human1.24808671
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24058367
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23642773
80* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22994777
81* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22893153
82* RARB_27405468_Chip-Seq_BRAIN_Mouse1.22567340
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22137472
84* TP63_22573176_ChIP-Seq_HFKS_Human1.19994149
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.19807179
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19735432
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18563923
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.17906215
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16824719
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16769236
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16407623
92RARB_24833708_ChIP-Seq_LIVER_Mouse1.16212432
93SA1_27219007_Chip-Seq_Bcells_Human1.15523721
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.15318434
95TP53_22127205_ChIP-Seq_IMR90_Human1.14503842
96CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13683683
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13669344
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12763375
99RNF2_27304074_Chip-Seq_ESCs_Mouse1.11971789
100IRF8_22096565_ChIP-ChIP_GC-B_Human1.11793627
101BCL6_27268052_Chip-Seq_Bcells_Human1.10673686
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10662646
103BCOR_27268052_Chip-Seq_Bcells_Human1.09944937
104JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09006781
105TRIM28_21343339_ChIP-Seq_HEK293_Human1.08763767
106* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07635945
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06923240
108E2F1_20622854_ChIP-Seq_HELA_Human1.06492162
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05356416
110* PHF8_20622854_ChIP-Seq_HELA_Human1.05230517
111MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05223881
112MYB_26560356_Chip-Seq_TH2_Human1.05174402
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04858563
114OCT4_19829295_ChIP-Seq_ESCs_Human1.04274302
115CTCF_21964334_Chip-Seq_Bcells_Human1.03838729
116SMC4_20622854_ChIP-Seq_HELA_Human1.03383113
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02560262
118JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01932270
119CTCF_26484167_Chip-Seq_Bcells_Mouse1.00372514
120SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99389504
121ETS1_21867929_ChIP-Seq_TH2_Mouse0.99365655
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98196396
123* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98141267
124PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97830619
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96658923
126* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96350233
127XRN2_22483619_ChIP-Seq_HELA_Human0.96111807
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95189864
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.94717340
130PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93922638
131RARA_24833708_ChIP-Seq_LIVER_Mouse0.93336682
132FOXP1_21924763_ChIP-Seq_HESCs_Human0.91919673
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.91575845
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.91575845
135* CHD1_26751641_Chip-Seq_LNCaP_Human0.90581895
136* TET1_21451524_ChIP-Seq_MESCs_Mouse0.90350694
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89624181
138IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88483859
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86938299

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003172_abnormal_lysosome_physiology3.62561804
2MP0003705_abnormal_hypodermis_morpholog3.40456486
3MP0004859_abnormal_synaptic_plasticity2.96889105
4MP0003300_gastrointestinal_ulcer2.95426573
5MP0006054_spinal_hemorrhage2.66544474
6MP0000751_myopathy2.64450621
7MP0003303_peritoneal_inflammation2.58599985
8MP0008961_abnormal_basal_metabolism2.47079532
9MP0005076_abnormal_cell_differentiation2.27292300
10MP0000537_abnormal_urethra_morphology2.20068837
11MP0010234_abnormal_vibrissa_follicle2.20065857
12MP0010352_gastrointestinal_tract_polyps2.18027235
13MP0001873_stomach_inflammation2.17847894
14MP0002909_abnormal_adrenal_gland2.07657777
15MP0009278_abnormal_bone_marrow2.04621966
16MP0004130_abnormal_muscle_cell1.99464148
17MP0004858_abnormal_nervous_system1.97249618
18MP0003787_abnormal_imprinting1.95439728
19MP0000747_muscle_weakness1.91534695
20MP0003879_abnormal_hair_cell1.85706945
21MP0004381_abnormal_hair_follicle1.84526191
22MP0001849_ear_inflammation1.82657234
23MP0005058_abnormal_lysosome_morphology1.80221659
24MP0002249_abnormal_larynx_morphology1.76921924
25MP0002877_abnormal_melanocyte_morpholog1.76035687
26MP0005409_darkened_coat_color1.72095078
27MP0003183_abnormal_peptide_metabolism1.71860811
28MP0005451_abnormal_body_composition1.71760022
29MP0003283_abnormal_digestive_organ1.69326394
30MP0004808_abnormal_hematopoietic_stem1.68266948
31MP0004087_abnormal_muscle_fiber1.67230261
32MP0002089_abnormal_postnatal_growth/wei1.65974637
33MP0004233_abnormal_muscle_weight1.59199072
34MP0002234_abnormal_pharynx_morphology1.55682202
35MP0004084_abnormal_cardiac_muscle1.55239885
36MP0004270_analgesia1.53581999
37MP0003656_abnormal_erythrocyte_physiolo1.51250887
38MP0002396_abnormal_hematopoietic_system1.49996305
39* MP0000733_abnormal_muscle_development1.48655125
40MP0005220_abnormal_exocrine_pancreas1.48221610
41MP0001502_abnormal_circadian_rhythm1.47671963
42MP0005670_abnormal_white_adipose1.42538314
43MP0004510_myositis1.41974561
44MP0003566_abnormal_cell_adhesion1.41899836
45MP0001348_abnormal_lacrimal_gland1.41729845
46MP0009840_abnormal_foam_cell1.41469405
47MP0000678_abnormal_parathyroid_gland1.40619069
48MP0005623_abnormal_meninges_morphology1.40183960
49MP0000681_abnormal_thyroid_gland1.38746099
50MP0003045_fibrosis1.37957878
51MP0000003_abnormal_adipose_tissue1.37685097
52MP0004185_abnormal_adipocyte_glucose1.35587716
53MP0000685_abnormal_immune_system1.34290857
54MP0002063_abnormal_learning/memory/cond1.31831818
55MP0005397_hematopoietic_system_phenotyp1.31612313
56MP0001545_abnormal_hematopoietic_system1.31612313
57MP0003123_paternal_imprinting1.30769219
58MP0002693_abnormal_pancreas_physiology1.30584020
59MP0010630_abnormal_cardiac_muscle1.29371546
60MP0002163_abnormal_gland_morphology1.27536615
61MP0001944_abnormal_pancreas_morphology1.27483879
62MP0000013_abnormal_adipose_tissue1.26880204
63MP0008438_abnormal_cutaneous_collagen1.24051894
64* MP0000759_abnormal_skeletal_muscle1.21458443
65MP0005187_abnormal_penis_morphology1.21408837
66MP0002822_catalepsy1.20695293
67MP0003866_abnormal_defecation1.20284707
68MP0004811_abnormal_neuron_physiology1.18547229
69MP0008770_decreased_survivor_rate1.17633879
70MP0003329_amyloid_beta_deposits1.16688479
71MP0001958_emphysema1.15651235
72MP0009780_abnormal_chondrocyte_physiolo1.15633001
73MP0004145_abnormal_muscle_electrophysio1.14660986
74MP0000703_abnormal_thymus_morphology1.14141799
75MP0005375_adipose_tissue_phenotype1.14034805
76MP0005330_cardiomyopathy1.12964287
77MP0002269_muscular_atrophy1.12253438
78MP0003763_abnormal_thymus_physiology1.11699353
79MP0003221_abnormal_cardiomyocyte_apopto1.10143221
80MP0000749_muscle_degeneration1.09909747
81MP0002064_seizures1.09126265
82MP0002106_abnormal_muscle_physiology1.08174637
83MP0001765_abnormal_ion_homeostasis1.07922047
84MP0003436_decreased_susceptibility_to1.06770071
85MP0000534_abnormal_ureter_morphology1.05742242
86MP0000604_amyloidosis1.05675911
87MP0002398_abnormal_bone_marrow1.05502771
88MP0008569_lethality_at_weaning1.03762146
89MP0003091_abnormal_cell_migration1.02645654
90MP0004197_abnormal_fetal_growth/weight/1.02333188
91MP0004215_abnormal_myocardial_fiber1.01831604
92MP0004947_skin_inflammation1.01339704
93MP0003279_aneurysm1.00729695
94MP0002970_abnormal_white_adipose0.99217398
95MP0001664_abnormal_digestion0.98093655
96MP0005379_endocrine/exocrine_gland_phen0.96789675
97MP0004036_abnormal_muscle_relaxation0.96519868
98MP0000428_abnormal_craniofacial_morphol0.96376503
99MP0000750_abnormal_muscle_regeneration0.95803724
100MP0000538_abnormal_urinary_bladder0.95347478
101MP0003634_abnormal_glial_cell0.94098829
102MP0005666_abnormal_adipose_tissue0.93996898
103MP0003115_abnormal_respiratory_system0.93903253
104MP0003635_abnormal_synaptic_transmissio0.93866319
105MP0003191_abnormal_cellular_cholesterol0.93376972
106MP0003567_abnormal_fetal_cardiomyocyte0.91216305
107MP0002933_joint_inflammation0.90740227
108MP0003690_abnormal_glial_cell0.89765930
109MP0001661_extended_life_span0.88646570
110MP0005360_urolithiasis0.88011187
111* MP0002080_prenatal_lethality0.87778777
112* MP0001730_embryonic_growth_arrest0.87756303
113MP0000490_abnormal_crypts_of0.85770259
114MP0002166_altered_tumor_susceptibility0.85513767
115MP0005083_abnormal_biliary_tract0.85410712
116MP0000350_abnormal_cell_proliferation0.85143033
117MP0001544_abnormal_cardiovascular_syste0.84920331
118MP0005385_cardiovascular_system_phenoty0.84920331
119MP0002078_abnormal_glucose_homeostasis0.83961286
120* MP0000266_abnormal_heart_morphology0.83276475
121MP0005381_digestive/alimentary_phenotyp0.82936955
122MP0008260_abnormal_autophagy0.82922255
123MP0002572_abnormal_emotion/affect_behav0.81441151
124MP0003122_maternal_imprinting0.81392524
125MP0010307_abnormal_tumor_latency0.80970775
126MP0002837_dystrophic_cardiac_calcinosis0.78558464
127MP0003646_muscle_fatigue0.77713667
128* MP0002925_abnormal_cardiovascular_devel0.76044927
129MP0005167_abnormal_blood-brain_barrier0.75788325
130MP0005448_abnormal_energy_balance0.75776126
131MP0005387_immune_system_phenotype0.75465495
132MP0001790_abnormal_immune_system0.75465495
133MP0003075_altered_response_to0.75258372
134MP0001299_abnormal_eye_distance/0.75247807
135MP0002896_abnormal_bone_mineralization0.75228362
136MP0002722_abnormal_immune_system0.74938638
137MP0005369_muscle_phenotype0.74893192
138MP0001663_abnormal_digestive_system0.73202554
139* MP0002084_abnormal_developmental_patter0.72447408
140MP0008874_decreased_physiological_sensi0.71634056
141MP0009672_abnormal_birth_weight0.71428376
142MP0000477_abnormal_intestine_morphology0.71276254
143* MP0001697_abnormal_embryo_size0.71021171
144MP0002876_abnormal_thyroid_physiology0.70674279
145MP0000955_abnormal_spinal_cord0.70508587
146MP0001784_abnormal_fluid_regulation0.70448915
147MP0000462_abnormal_digestive_system0.69965936
148MP0003137_abnormal_impulse_conducting0.69668159
149MP0002932_abnormal_joint_morphology0.67653856
150MP0005452_abnormal_adipose_tissue0.66976713
151MP0000470_abnormal_stomach_morphology0.66958609
152MP0008775_abnormal_heart_ventricle0.66893626
153MP0002972_abnormal_cardiac_muscle0.65516871
154MP0001970_abnormal_pain_threshold0.64690581
155MP0002733_abnormal_thermal_nociception0.64476810
156MP0009745_abnormal_behavioral_response0.61659802
157MP0005645_abnormal_hypothalamus_physiol0.61596725
158MP0005025_abnormal_response_to0.61578042
159MP0003453_abnormal_keratinocyte_physiol0.61575147
160MP0001270_distended_abdomen0.61168919

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)5.11669010
2Obstructive sleep apnea (HP:0002870)4.67377996
3Hyperacusis (HP:0010780)4.61664058
4Stridor (HP:0010307)3.99541167
5Insomnia (HP:0100785)3.96466926
6Broad face (HP:0000283)3.42265385
7Elfin facies (HP:0004428)3.23112481
8Cerebral aneurysm (HP:0004944)3.13405980
9J-shaped sella turcica (HP:0002680)3.08301506
10Overriding aorta (HP:0002623)3.07217949
11Hyperthyroidism (HP:0000836)3.05264624
12Renal duplication (HP:0000075)2.96629898
13Dysostosis multiplex (HP:0000943)2.89579736
14Pointed chin (HP:0000307)2.77913156
15Abnormality of polysaccharide metabolism (HP:0011012)2.75945145
16Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75945145
17Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75945145
18Renovascular hypertension (HP:0100817)2.74494627
19Shallow orbits (HP:0000586)2.73367431
20Urinary glycosaminoglycan excretion (HP:0003541)2.71849586
21Mucopolysacchariduria (HP:0008155)2.71849586
22Thoracic kyphosis (HP:0002942)2.71480073
23Protrusio acetabuli (HP:0003179)2.65222667
24Abnormality of the thoracic spine (HP:0100711)2.64162536
25Bowel diverticulosis (HP:0005222)2.59639404
26Hypercortisolism (HP:0001578)2.55869451
27Achilles tendon contracture (HP:0001771)2.52362953
28Increased density of long bones (HP:0006392)2.47962963
29Bladder diverticulum (HP:0000015)2.47789029
30Germ cell neoplasia (HP:0100728)2.47595896
31Distal lower limb amyotrophy (HP:0008944)2.46333663
32Limb-girdle muscle atrophy (HP:0003797)2.45798511
33Easy fatigability (HP:0003388)2.41973027
34Flat cornea (HP:0007720)2.40826457
35Difficulty running (HP:0009046)2.38073485
36Macroorchidism (HP:0000053)2.37587305
37Enlarged penis (HP:0000040)2.37410705
38Distal upper limb amyotrophy (HP:0007149)2.36954221
39Upper limb amyotrophy (HP:0009129)2.36954221
40Cervical subluxation (HP:0003308)2.35118025
41Short 4th metacarpal (HP:0010044)2.34286003
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34286003
43Spinal canal stenosis (HP:0003416)2.28142941
44Broad metatarsal (HP:0001783)2.25457858
45Visceral angiomatosis (HP:0100761)2.23750721
46Lymphangioma (HP:0100764)2.23480775
47Joint stiffness (HP:0001387)2.22119905
48Advanced eruption of teeth (HP:0006288)2.21537447
49Thin bony cortex (HP:0002753)2.20469709
50Testicular neoplasm (HP:0010788)2.17694121
51Truncus arteriosus (HP:0001660)2.16965821
52Hallux valgus (HP:0001822)2.16385523
53Difficulty climbing stairs (HP:0003551)2.16082969
54Dilatation of the ascending aorta (HP:0005111)2.15610366
55Natal tooth (HP:0000695)2.15527194
56Abnormality of the Achilles tendon (HP:0005109)2.14756207
57Disproportionate tall stature (HP:0001519)2.14038593
58Papilloma (HP:0012740)2.13667411
59Verrucae (HP:0200043)2.13667411
60Increased variability in muscle fiber diameter (HP:0003557)2.13013615
61Growth hormone excess (HP:0000845)2.12978615
62Deviation of the hallux (HP:0010051)2.12837694
63Mitral valve prolapse (HP:0001634)2.12322705
64Type 1 muscle fiber predominance (HP:0003803)2.12085350
65Neoplasm of the heart (HP:0100544)2.11600960
66Neoplasm of the adrenal cortex (HP:0100641)2.11372370
67Myokymia (HP:0002411)2.10580832
68Hand muscle atrophy (HP:0009130)2.10001312
69Subacute progressive viral hepatitis (HP:0006572)2.07486630
70Polygenic inheritance (HP:0010982)2.07264145
71Ankyloglossia (HP:0010296)2.07190876
72Papilledema (HP:0001085)2.04107107
73Ankle contracture (HP:0006466)2.04067662
74Lower limb asymmetry (HP:0100559)2.02976741
75Abnormality of oral frenula (HP:0000190)2.02358055
76Long toe (HP:0010511)2.02228302
77Abnormality of skeletal muscle fiber size (HP:0012084)2.02193918
78Abnormality of the 4th metacarpal (HP:0010012)2.01743104
79Striae distensae (HP:0001065)2.01051841
80Nuclear cataract (HP:0100018)2.00531004
81Rectal prolapse (HP:0002035)1.98302809
82Pelvic girdle muscle weakness (HP:0003749)1.97638181
83Deep palmar crease (HP:0006191)1.97457066
84Bundle branch block (HP:0011710)1.97003882
85Hemangiomatosis (HP:0007461)1.95930784
86Annular pancreas (HP:0001734)1.95880340
87Ulnar bowing (HP:0003031)1.95630898
88Genu recurvatum (HP:0002816)1.94772510
89Diminished motivation (HP:0000745)1.93757450
90Malnutrition (HP:0004395)1.92780379
91Apathy (HP:0000741)1.92356171
92Abnormality of the aortic arch (HP:0012303)1.92211655
93Tracheomalacia (HP:0002779)1.91028228
94Angiofibromas (HP:0010615)1.90874637
95Adenoma sebaceum (HP:0009720)1.90874637
96Depression (HP:0000716)1.90841265
97Bronchomalacia (HP:0002780)1.90146329
98Exercise-induced muscle cramps (HP:0003710)1.90100921
99Emphysema (HP:0002097)1.88871351
100Unilateral renal agenesis (HP:0000122)1.87637150
101Sacral dimple (HP:0000960)1.87408161
102Congenital glaucoma (HP:0001087)1.86988313
103Frequent falls (HP:0002359)1.86657024
104Aortic aneurysm (HP:0004942)1.86576956
105Scapular winging (HP:0003691)1.86534201
106Hemorrhage of the eye (HP:0011885)1.85352284
107Fibroma (HP:0010614)1.85144480
108Ankle clonus (HP:0011448)1.85058607
109Distal lower limb muscle weakness (HP:0009053)1.83802650
110Increased nuchal translucency (HP:0010880)1.82882049
111Broad palm (HP:0001169)1.82785576
112Craniofacial hyperostosis (HP:0004493)1.81969331
113Aneurysm (HP:0002617)1.81624003
114Hypoventilation (HP:0002791)1.81515855
115Supranuclear gaze palsy (HP:0000605)1.80976614
116Abnormality of the lumbar spine (HP:0100712)1.80835729
117Increased connective tissue (HP:0009025)1.80592785
118Megalencephaly (HP:0001355)1.80489575
119Myopathic facies (HP:0002058)1.80400805
120Sleep apnea (HP:0010535)1.80269257
121Megalocornea (HP:0000485)1.79940710
122Mildly elevated creatine phosphokinase (HP:0008180)1.79810911
123Lower limb amyotrophy (HP:0007210)1.79668854
124Centrally nucleated skeletal muscle fibers (HP:0003687)1.78676786
125Abnormality of the hip-girdle musculature (HP:0001445)1.78342246
126Abnormality of the musculature of the pelvis (HP:0001469)1.78342246
127Fibrous tissue neoplasm (HP:0012316)1.78007639
128Precocious puberty (HP:0000826)1.77902573
129Adducted thumb (HP:0001181)1.76664802
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76548648
131Urinary urgency (HP:0000012)1.75929306
132Sudden death (HP:0001699)1.74818635
133Rapidly progressive (HP:0003678)1.73968576
134Cellulitis (HP:0100658)1.73450284
135Shoulder girdle muscle weakness (HP:0003547)1.73349460
136Radial bowing (HP:0002986)1.72228681
137Hamartoma of the eye (HP:0010568)1.72174265
138Eczematoid dermatitis (HP:0000976)1.71227094
139Exostoses (HP:0100777)1.71178893
140Bicuspid aortic valve (HP:0001647)1.70654820
141Ventricular fibrillation (HP:0001663)1.70003053
142Myoglobinuria (HP:0002913)1.69996276
143Abnormality of the fingertips (HP:0001211)1.69256401
144Turricephaly (HP:0000262)1.68608280
145Neuronal loss in central nervous system (HP:0002529)1.68588469
146Myotonia (HP:0002486)1.68507258
147Resting tremor (HP:0002322)1.68128836
148Exercise-induced myalgia (HP:0003738)1.68084575
149Hypercalcemia (HP:0003072)1.67921599
150Atelectasis (HP:0100750)1.67767716
151Dysmetric saccades (HP:0000641)1.67662338
152Ulnar deviation of the wrist (HP:0003049)1.66806203
153Mitral regurgitation (HP:0001653)1.66734315
154Visual hallucinations (HP:0002367)1.66694566
155Supernumerary nipples (HP:0002558)1.66323655
156Hyperparathyroidism (HP:0000843)1.64709812
157Asymmetric growth (HP:0100555)1.64406349
158Round ear (HP:0100830)1.63805785
159Urethral obstruction (HP:0000796)1.62437029
160Neonatal hypoglycemia (HP:0001998)1.62405024
161Colitis (HP:0002583)1.61175559
162Generalized hyperpigmentation (HP:0007440)1.60886724
163Buphthalmos (HP:0000557)1.60348700
164Cerebral inclusion bodies (HP:0100314)1.59894684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.94301472
2EEF2K4.58086567
3PKN24.57465449
4SMG13.85959573
5MAP3K103.57302538
6SCYL22.48311307
7TTN2.31133139
8PRPF4B2.24512684
9TNK22.13358647
10RIPK12.10347785
11LRRK21.93398149
12PTK61.87356447
13KSR21.74258251
14PDGFRA1.70862764
15MAP4K11.68426160
16IRAK31.67543903
17ERN11.65943127
18PRKD21.60701231
19CAMKK11.52144817
20FGFR21.50222857
21TAOK11.44057127
22SIK21.43441230
23EPHA21.40892462
24ALK1.40015926
25LMTK21.39987623
26RIPK41.35259896
27RET1.32927274
28PRKD31.32719359
29ILK1.30254368
30MAP3K91.27244388
31TESK21.26291166
32MAP3K131.26142906
33PRKG21.21919989
34MAP2K61.18783087
35DMPK1.15512441
36MAP3K71.13597202
37SIK11.12233616
38NTRK31.11685620
39NEK11.10256739
40ICK1.08327817
41PAK41.04914900
42TYRO30.99930570
43MAPKAPK30.99417715
44KSR10.99135441
45PAK60.98748145
46GRK60.97332498
47* HIPK20.96213762
48PHKG10.92201199
49PHKG20.92201199
50FLT30.90241092
51UHMK10.90089665
52CDC42BPA0.89353361
53TESK10.87474654
54PRKCH0.86631639
55NEK20.85733597
56FGFR30.83052503
57MAP3K20.82325777
58MAPK120.82212995
59PAK20.80358272
60RPS6KC10.80135970
61RPS6KL10.80135970
62DAPK20.80056763
63DYRK1B0.79661242
64TGFBR10.79593776
65BMX0.79145124
66MAP2K30.77135603
67MAP3K80.77088830
68MARK10.76597084
69NTRK10.74982993
70CDK190.74173005
71LIMK10.74164696
72ZAP700.73668069
73MINK10.73022883
74RPS6KB20.70882810
75SGK30.68686561
76RPS6KA20.68330195
77MAP2K20.66015717
78MTOR0.65688185
79DAPK30.64960457
80TYK20.64181105
81RPS6KA60.62983587
82FGFR40.62725897
83MAP3K10.61714677
84PASK0.61238702
85PDGFRB0.60778570
86JAK20.59562249
87STK100.59387160
88SIK30.57937628
89DDR20.57648818
90PRKCI0.57522444
91MARK20.57324297
92PRKD10.56796762
93MST1R0.56530226
94CAMK10.55000047
95CDK40.54829211
96MAP3K110.53829599
97PTK20.52150228
98CDK150.51913495
99CAMKK20.51551650
100IRAK20.51162602
101ITK0.50979799
102PDK10.50445071
103CDK11A0.50163558
104BTK0.50040673
105CSF1R0.49624188
106TGFBR20.48633644
107TBK10.48562431
108DAPK10.48280509
109CAMK1G0.47702681
110CDK140.47269659
111ARAF0.47025180
112JAK30.46930799
113CDK50.46659796
114CDK60.46633889
115MAP3K30.46344117
116CDK180.45981968
117EPHA40.45896077
118PRKAA20.45811869
119MAPK110.45439452
120KDR0.45434824
121HCK0.43625644
122EPHB10.43060380
123GRK50.41448556
124STK110.39555521
125PRKCZ0.39358329
126RPS6KA10.39170002
127PDPK10.38639079
128SYK0.38404461
129IRAK40.38107460
130CAMK1D0.37748106
131AKT20.37336266
132MUSK0.36638265
133FGFR10.35705753
134JAK10.35429525
135STK380.33867310
136RPS6KA40.33740557
137FES0.33502099
138* PRKAA10.33332035
139TRPM70.32787600
140* MAPK80.31150917
141TAOK20.30549535

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005111.98021644
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92194699
3* Chronic myeloid leukemia_Homo sapiens_hsa052201.89945622
4Non-small cell lung cancer_Homo sapiens_hsa052231.73225068
5Neurotrophin signaling pathway_Homo sapiens_hsa047221.68370920
6Cyanoamino acid metabolism_Homo sapiens_hsa004601.66880981
7Glioma_Homo sapiens_hsa052141.66863239
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.66636453
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.66510739
10VEGF signaling pathway_Homo sapiens_hsa043701.64256688
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61279327
12Synaptic vesicle cycle_Homo sapiens_hsa047211.58168805
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56508476
14Vitamin B6 metabolism_Homo sapiens_hsa007501.53244353
15B cell receptor signaling pathway_Homo sapiens_hsa046621.49726587
16mTOR signaling pathway_Homo sapiens_hsa041501.46705580
17Endometrial cancer_Homo sapiens_hsa052131.46429511
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39934601
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.39355567
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39350802
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36083764
22Colorectal cancer_Homo sapiens_hsa052101.35604959
23Estrogen signaling pathway_Homo sapiens_hsa049151.26346711
24Viral myocarditis_Homo sapiens_hsa054161.24533280
25Bladder cancer_Homo sapiens_hsa052191.24367829
26Platelet activation_Homo sapiens_hsa046111.22736175
27Pancreatic cancer_Homo sapiens_hsa052121.22453741
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20957415
29Proteoglycans in cancer_Homo sapiens_hsa052051.19414095
30Insulin signaling pathway_Homo sapiens_hsa049101.18811715
31Focal adhesion_Homo sapiens_hsa045101.17879760
32Acute myeloid leukemia_Homo sapiens_hsa052211.17081856
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16053715
34Gap junction_Homo sapiens_hsa045401.14073672
35Renal cell carcinoma_Homo sapiens_hsa052111.13876967
36Thyroid cancer_Homo sapiens_hsa052161.13463976
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12226690
38Gastric acid secretion_Homo sapiens_hsa049711.11634959
39Long-term potentiation_Homo sapiens_hsa047201.09154547
40Type II diabetes mellitus_Homo sapiens_hsa049301.08743263
41Choline metabolism in cancer_Homo sapiens_hsa052311.08380186
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08039239
43Insulin resistance_Homo sapiens_hsa049311.07873045
44Dilated cardiomyopathy_Homo sapiens_hsa054141.06442636
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03799587
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03278276
47Inositol phosphate metabolism_Homo sapiens_hsa005621.02463884
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02403212
49Endocytosis_Homo sapiens_hsa041441.01922681
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.01052874
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.99683879
52Small cell lung cancer_Homo sapiens_hsa052220.98523105
53Prolactin signaling pathway_Homo sapiens_hsa049170.98396321
54Amphetamine addiction_Homo sapiens_hsa050310.97802492
55Shigellosis_Homo sapiens_hsa051310.97686879
56Oxytocin signaling pathway_Homo sapiens_hsa049210.97516539
57GnRH signaling pathway_Homo sapiens_hsa049120.97124534
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96714441
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.96549779
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95805552
61T cell receptor signaling pathway_Homo sapiens_hsa046600.95046286
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.94854692
63AMPK signaling pathway_Homo sapiens_hsa041520.94456625
64Alcoholism_Homo sapiens_hsa050340.94406219
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93470595
66Renin secretion_Homo sapiens_hsa049240.92384861
67Cholinergic synapse_Homo sapiens_hsa047250.91752518
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90557586
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90364970
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89516610
71Olfactory transduction_Homo sapiens_hsa047400.88892308
72Long-term depression_Homo sapiens_hsa047300.88757197
73Dopaminergic synapse_Homo sapiens_hsa047280.88724186
74Fructose and mannose metabolism_Homo sapiens_hsa000510.88703996
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88432889
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.88365483
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86965755
78HTLV-I infection_Homo sapiens_hsa051660.86183319
79Viral carcinogenesis_Homo sapiens_hsa052030.85659981
80Osteoclast differentiation_Homo sapiens_hsa043800.85385875
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85107268
82Glutamatergic synapse_Homo sapiens_hsa047240.83907115
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83852065
84ErbB signaling pathway_Homo sapiens_hsa040120.83213374
85Toxoplasmosis_Homo sapiens_hsa051450.83034313
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80581316
87MicroRNAs in cancer_Homo sapiens_hsa052060.80254514
88Vibrio cholerae infection_Homo sapiens_hsa051100.79835783
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79189107
90HIF-1 signaling pathway_Homo sapiens_hsa040660.78883953
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76933751
92Oocyte meiosis_Homo sapiens_hsa041140.76928440
93* Notch signaling pathway_Homo sapiens_hsa043300.76910508
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.76714665
95Chemokine signaling pathway_Homo sapiens_hsa040620.76029016
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75253270
97Melanogenesis_Homo sapiens_hsa049160.73229941
98Morphine addiction_Homo sapiens_hsa050320.73135309
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73134115
100Hepatitis B_Homo sapiens_hsa051610.72813153
101Prion diseases_Homo sapiens_hsa050200.72757816
102Insulin secretion_Homo sapiens_hsa049110.72375344
103Circadian entrainment_Homo sapiens_hsa047130.72162951
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71942026
105Apoptosis_Homo sapiens_hsa042100.71179183
106Rap1 signaling pathway_Homo sapiens_hsa040150.70370874
107Axon guidance_Homo sapiens_hsa043600.70311564
108Salmonella infection_Homo sapiens_hsa051320.68655462
109Glucagon signaling pathway_Homo sapiens_hsa049220.67619302
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67026312
111N-Glycan biosynthesis_Homo sapiens_hsa005100.66988591
112Pentose phosphate pathway_Homo sapiens_hsa000300.66944209
113Amoebiasis_Homo sapiens_hsa051460.66590618
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66433975
115Hippo signaling pathway_Homo sapiens_hsa043900.65759484
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.65381568
117Dorso-ventral axis formation_Homo sapiens_hsa043200.64593651
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63656258
119MAPK signaling pathway_Homo sapiens_hsa040100.63586508
120Lysosome_Homo sapiens_hsa041420.63553714
121Thyroid hormone synthesis_Homo sapiens_hsa049180.63414446
122Cocaine addiction_Homo sapiens_hsa050300.62860257
123Hepatitis C_Homo sapiens_hsa051600.62717737
124Adherens junction_Homo sapiens_hsa045200.61884538
125Salivary secretion_Homo sapiens_hsa049700.61715218
126cAMP signaling pathway_Homo sapiens_hsa040240.61183606
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60877593
128Calcium signaling pathway_Homo sapiens_hsa040200.59507771
129Lysine degradation_Homo sapiens_hsa003100.56900990
130Pancreatic secretion_Homo sapiens_hsa049720.53392438

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