CTAGE9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)9.24588281
2DNA synthesis involved in DNA repair (GO:0000731)8.55508366
3chromosome organization involved in meiosis (GO:0070192)8.45468930
4meiosis I (GO:0007127)7.81443214
5piRNA metabolic process (GO:0034587)7.72902605
6male meiosis (GO:0007140)7.45670972
7DNA methylation involved in gamete generation (GO:0043046)6.79475987
8synaptonemal complex assembly (GO:0007130)6.58311561
9synaptonemal complex organization (GO:0070193)6.00212070
10meiotic nuclear division (GO:0007126)5.75699248
11reciprocal DNA recombination (GO:0035825)5.58993114
12reciprocal meiotic recombination (GO:0007131)5.58993114
13resolution of meiotic recombination intermediates (GO:0000712)4.93821744
14meiotic cell cycle process (GO:1903046)4.89778018
15maturation of SSU-rRNA (GO:0030490)4.63142463
16proteasome assembly (GO:0043248)4.20895210
17ribosome assembly (GO:0042255)4.15921279
18ATP synthesis coupled proton transport (GO:0015986)3.77783436
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77783436
20regulation of cilium movement (GO:0003352)3.76330676
21regulation of meiosis I (GO:0060631)3.68242555
22DNA double-strand break processing (GO:0000729)3.60706342
23cell wall macromolecule catabolic process (GO:0016998)3.57662789
24sister chromatid cohesion (GO:0007062)3.52321203
25short-chain fatty acid metabolic process (GO:0046459)3.51093309
26protein localization to chromosome (GO:0034502)3.45459652
27nonmotile primary cilium assembly (GO:0035058)3.39331418
28sperm motility (GO:0030317)3.33226875
29gene silencing by RNA (GO:0031047)3.31477338
30chaperone-mediated protein transport (GO:0072321)3.30876601
31spermatid development (GO:0007286)3.27958762
32histone exchange (GO:0043486)3.22130749
33DNA catabolic process, exonucleolytic (GO:0000738)3.21748752
34ribosomal small subunit biogenesis (GO:0042274)3.17253530
35female gamete generation (GO:0007292)3.16770337
36cell wall macromolecule metabolic process (GO:0044036)3.15781336
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15059057
38fusion of sperm to egg plasma membrane (GO:0007342)3.14619692
39mitotic sister chromatid cohesion (GO:0007064)3.10473622
40negative regulation of DNA repair (GO:0045738)3.10301053
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10224376
42meiotic chromosome segregation (GO:0045132)3.10205663
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08220304
44attachment of spindle microtubules to kinetochore (GO:0008608)3.05798328
45histone H3-K9 demethylation (GO:0033169)3.02986912
46negative regulation of inclusion body assembly (GO:0090084)2.98048712
47viral transcription (GO:0019083)2.93546751
48translational termination (GO:0006415)2.90881392
49maturation of 5.8S rRNA (GO:0000460)2.89945088
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86920255
51regulation of mitotic spindle checkpoint (GO:1903504)2.86920255
52nuclear pore complex assembly (GO:0051292)2.83681479
53photoreceptor cell maintenance (GO:0045494)2.83644731
54oxygen transport (GO:0015671)2.81187122
55nuclear pore organization (GO:0006999)2.80525326
56reproductive system development (GO:0061458)2.80355246
57spliceosomal snRNP assembly (GO:0000387)2.79812106
58centriole replication (GO:0007099)2.79671920
59otic vesicle formation (GO:0030916)2.78396680
60regulation of centriole replication (GO:0046599)2.77012672
61negative regulation of DNA-dependent DNA replication (GO:2000104)2.74694461
62CENP-A containing nucleosome assembly (GO:0034080)2.74364770
63regulation of microtubule-based movement (GO:0060632)2.73600428
64protein targeting to Golgi (GO:0000042)2.73337075
65genitalia morphogenesis (GO:0035112)2.72891421
66artery smooth muscle contraction (GO:0014824)2.71305668
67establishment of protein localization to mitochondrial membrane (GO:0090151)2.70829729
68negative regulation of gene silencing (GO:0060969)2.68936107
69replication fork processing (GO:0031297)2.62258366
70chromatin remodeling at centromere (GO:0031055)2.62058475
71negative regulation of appetite (GO:0032099)2.61798560
72negative regulation of response to food (GO:0032096)2.61798560
73establishment of protein localization to Golgi (GO:0072600)2.60682367
74DNA packaging (GO:0006323)2.59850798
75DNA alkylation (GO:0006305)2.58839237
76DNA methylation (GO:0006306)2.58839237
77chromosome organization (GO:0051276)2.57745473
78male gamete generation (GO:0048232)2.54999110
79germ cell development (GO:0007281)2.54640332
80spermatogenesis (GO:0007283)2.54140647
81gamete generation (GO:0007276)2.51898448
82kinetochore organization (GO:0051383)2.51181250
83somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.50574885
84somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.50574885
85isotype switching (GO:0045190)2.50574885
86acrosome reaction (GO:0007340)2.50022895
87striatum development (GO:0021756)2.48932402
88intracellular protein transmembrane import (GO:0044743)2.48869108
89regulation of glucokinase activity (GO:0033131)2.48735970
90regulation of hexokinase activity (GO:1903299)2.48735970
91DNA biosynthetic process (GO:0071897)2.48154982
92mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.47894137
93negative regulation of mitotic sister chromatid separation (GO:2000816)2.46454974
94negative regulation of sister chromatid segregation (GO:0033046)2.46454974
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.46454974
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.46454974
97negative regulation of mitotic sister chromatid segregation (GO:0033048)2.46454974
98regulation of meiotic cell cycle (GO:0051445)2.45312244
99DNA ligation (GO:0006266)2.41741747
100synapsis (GO:0007129)12.6761887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.35955888
2VDR_22108803_ChIP-Seq_LS180_Human3.34414365
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.23465497
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.03295589
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86450690
6FUS_26573619_Chip-Seq_HEK293_Human2.85387526
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77499187
8ZNF274_21170338_ChIP-Seq_K562_Hela2.75066946
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.69681167
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.62303568
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.62098912
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60455957
13ELK1_19687146_ChIP-ChIP_HELA_Human2.59993436
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59518256
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56189242
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43760163
17ER_23166858_ChIP-Seq_MCF-7_Human2.26152105
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.08684772
19EWS_26573619_Chip-Seq_HEK293_Human1.95102607
20MYC_18940864_ChIP-ChIP_HL60_Human1.89995725
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86720577
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86629060
23E2F7_22180533_ChIP-Seq_HELA_Human1.76140402
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73246935
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.71416712
26RNF2_27304074_Chip-Seq_NSC_Mouse1.70674559
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65789903
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62443238
29VDR_23849224_ChIP-Seq_CD4+_Human1.61947058
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61769949
31FOXA1_21572438_ChIP-Seq_LNCaP_Human1.51519666
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51296247
33TP53_22573176_ChIP-Seq_HFKS_Human1.49941909
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.48708701
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48100710
36P300_19829295_ChIP-Seq_ESCs_Human1.46330442
37BCAT_22108803_ChIP-Seq_LS180_Human1.45552843
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43374292
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42188260
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42019673
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41981537
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.41093190
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36804156
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.36070740
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34506774
46TTF2_22483619_ChIP-Seq_HELA_Human1.33165431
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32168472
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31859141
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.31507532
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29108257
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27801745
52FOXP3_21729870_ChIP-Seq_TREG_Human1.25785085
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24759014
54IGF1R_20145208_ChIP-Seq_DFB_Human1.24584041
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24491470
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24483401
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24085021
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.24085021
59IRF1_19129219_ChIP-ChIP_H3396_Human1.23944046
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23781368
61CBP_20019798_ChIP-Seq_JUKART_Human1.23781368
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23760289
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21454593
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.21208150
65TCF4_22108803_ChIP-Seq_LS180_Human1.19044969
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.18033338
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17291387
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.17202113
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17052372
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16089701
71RUNX2_22187159_ChIP-Seq_PCA_Human1.15939585
72AR_25329375_ChIP-Seq_VCAP_Human1.15933873
73AR_20517297_ChIP-Seq_VCAP_Human1.13436537
74NANOG_19829295_ChIP-Seq_ESCs_Human1.13358231
75SOX2_19829295_ChIP-Seq_ESCs_Human1.13358231
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11109300
77TAF15_26573619_Chip-Seq_HEK293_Human1.10352763
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09988341
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.09832801
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08926327
81ERA_21632823_ChIP-Seq_H3396_Human1.08545378
82HOXB7_26014856_ChIP-Seq_BT474_Human1.08185918
83KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07043796
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06923540
85NCOR_22424771_ChIP-Seq_293T_Human1.06861214
86FOXH1_21741376_ChIP-Seq_EPCs_Human1.06837144
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.04204523
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04080860
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.02823123
90RBPJ_21746931_ChIP-Seq_IB4_Human1.02158875
91ETV1_20927104_ChIP-Seq_GIST48_Human0.99950443
92CDX2_22108803_ChIP-Seq_LS180_Human0.99819645
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99649274
94TCF4_23295773_ChIP-Seq_U87_Human0.99596558
95PHF8_20622853_ChIP-Seq_HELA_Human0.98931116
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.97861148
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97123815
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96860100
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95090617
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94856282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.71461381
2MP0009379_abnormal_foot_pigmentation3.97985743
3MP0003136_yellow_coat_color3.76821612
4MP0006292_abnormal_olfactory_placode3.75440625
5MP0002160_abnormal_reproductive_system3.66186933
6MP0008004_abnormal_stomach_pH2.90691738
7MP0002210_abnormal_sex_determination2.81375708
8MP0008058_abnormal_DNA_repair2.67230036
9MP0009697_abnormal_copulation2.64892407
10MP0001188_hyperpigmentation2.55427896
11MP0001929_abnormal_gametogenesis2.41350030
12MP0005389_reproductive_system_phenotype2.35526750
13MP0000372_irregular_coat_pigmentation2.28080580
14MP0003698_abnormal_male_reproductive2.24422796
15MP0001661_extended_life_span2.11826837
16MP0005410_abnormal_fertilization2.10528893
17MP0000653_abnormal_sex_gland2.01112598
18MP0001145_abnormal_male_reproductive1.96721178
19MP0003693_abnormal_embryo_hatching1.95539427
20MP0003890_abnormal_embryonic-extraembry1.94069677
21MP0001485_abnormal_pinna_reflex1.91442336
22MP0000383_abnormal_hair_follicle1.89664192
23MP0004885_abnormal_endolymph1.87390644
24MP0008995_early_reproductive_senescence1.86612917
25MP0000427_abnormal_hair_cycle1.86269606
26MP0004147_increased_porphyrin_level1.78552232
27MP0002095_abnormal_skin_pigmentation1.76998619
28MP0002254_reproductive_system_inflammat1.68826172
29MP0005275_abnormal_skin_tensile1.68105083
30MP0000579_abnormal_nail_morphology1.67659255
31MP0003718_maternal_effect1.66975716
32MP0003315_abnormal_perineum_morphology1.65079146
33MP0002277_abnormal_respiratory_mucosa1.64908712
34MP0003806_abnormal_nucleotide_metabolis1.51301828
35MP0003941_abnormal_skin_development1.48915331
36MP0006276_abnormal_autonomic_nervous1.48776354
37MP0004957_abnormal_blastocyst_morpholog1.47322500
38MP0000647_abnormal_sebaceous_gland1.46291097
39MP0001119_abnormal_female_reproductive1.45686739
40MP0004742_abnormal_vestibular_system1.38944680
41MP0005187_abnormal_penis_morphology1.36554730
42MP0003567_abnormal_fetal_cardiomyocyte1.32945419
43MP0001293_anophthalmia1.28706686
44MP0002102_abnormal_ear_morphology1.27714059
45MP0003878_abnormal_ear_physiology1.26208313
46MP0005377_hearing/vestibular/ear_phenot1.26208313
47MP0001984_abnormal_olfaction1.25151663
48MP0003786_premature_aging1.18293721
49MP0000631_abnormal_neuroendocrine_gland1.17600835
50MP0002161_abnormal_fertility/fecundity1.12930071
51MP0010094_abnormal_chromosome_stability1.12551597
52MP0010678_abnormal_skin_adnexa1.10654573
53MP0001529_abnormal_vocalization1.07857375
54MP0002132_abnormal_respiratory_system1.06479563
55MP0009250_abnormal_appendicular_skeleto1.03676128
56MP0003699_abnormal_female_reproductive1.03017701
57MP0003937_abnormal_limbs/digits/tail_de0.99671316
58MP0003123_paternal_imprinting0.96537140
59MP0004381_abnormal_hair_follicle0.95410545
60MP0003011_delayed_dark_adaptation0.95152951
61MP0002282_abnormal_trachea_morphology0.94523078
62MP0008057_abnormal_DNA_replication0.94177211
63MP0002249_abnormal_larynx_morphology0.93570873
64MP0005310_abnormal_salivary_gland0.92486784
65MP0004043_abnormal_pH_regulation0.89578039
66MP0005075_abnormal_melanosome_morpholog0.88812450
67MP0004019_abnormal_vitamin_homeostasis0.88712268
68MP0004142_abnormal_muscle_tone0.87973838
69MP0006054_spinal_hemorrhage0.86988370
70MP0002163_abnormal_gland_morphology0.85806649
71MP0003950_abnormal_plasma_membrane0.83017123
72MP0000049_abnormal_middle_ear0.80146403
73MP0005551_abnormal_eye_electrophysiolog0.79562228
74MP0003111_abnormal_nucleus_morphology0.78295938
75MP0004133_heterotaxia0.77329274
76MP0008007_abnormal_cellular_replicative0.74162024
77MP0005670_abnormal_white_adipose0.73395050
78MP0000778_abnormal_nervous_system0.73041390
79MP0001881_abnormal_mammary_gland0.72814016
80MP0009703_decreased_birth_body0.71454437
81MP0003283_abnormal_digestive_organ0.70860522
82MP0001697_abnormal_embryo_size0.70289324
83MP0002084_abnormal_developmental_patter0.69641424
84MP0001501_abnormal_sleep_pattern0.67855459
85MP0001486_abnormal_startle_reflex0.66152137
86MP0001666_abnormal_nutrient_absorption0.65207911
87MP0001919_abnormal_reproductive_system0.64387611
88MP0003936_abnormal_reproductive_system0.64367589
89MP0005646_abnormal_pituitary_gland0.63910192
90MP0000537_abnormal_urethra_morphology0.63618695
91MP0000358_abnormal_cell_content/0.63582819
92MP0001286_abnormal_eye_development0.63096867
93MP0001963_abnormal_hearing_physiology0.61769499
94MP0003938_abnormal_ear_development0.61751921
95MP0000678_abnormal_parathyroid_gland0.60481059
96MP0010352_gastrointestinal_tract_polyps0.59041611
97MP0008872_abnormal_physiological_respon0.58397576
98MP0000026_abnormal_inner_ear0.57506131
99MP0003137_abnormal_impulse_conducting0.56993259
100MP0002109_abnormal_limb_morphology0.53470058

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)4.98447001
2Oligodactyly (hands) (HP:0001180)4.89292949
3Reticulocytopenia (HP:0001896)4.79633190
4Volvulus (HP:0002580)3.75276168
5Abnormal hemoglobin (HP:0011902)3.65331740
6Pili torti (HP:0003777)3.45655765
7Azoospermia (HP:0000027)3.43719369
8Shoulder girdle muscle weakness (HP:0003547)3.39383580
9Ectopic kidney (HP:0000086)3.36232161
10Abnormality of midbrain morphology (HP:0002418)3.25357810
11Molar tooth sign on MRI (HP:0002419)3.25357810
12Hyperglycinemia (HP:0002154)3.01114574
13Acute encephalopathy (HP:0006846)2.97104532
14Oligodactyly (HP:0012165)2.94248912
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89768118
16Degeneration of the lateral corticospinal tracts (HP:0002314)2.89768118
17Rimmed vacuoles (HP:0003805)2.88200769
18Hyperalaninemia (HP:0003348)2.85712941
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85712941
20Abnormality of alanine metabolism (HP:0010916)2.85712941
21Pallor (HP:0000980)2.75995467
22Hyperglycinuria (HP:0003108)2.74051592
23Abnormality of the renal cortex (HP:0011035)2.69392062
24Follicular hyperkeratosis (HP:0007502)2.68575856
25Partial duplication of thumb phalanx (HP:0009944)2.67478335
26Chronic hepatic failure (HP:0100626)2.66111974
27Methylmalonic acidemia (HP:0002912)2.62129787
28Abnormality of the labia minora (HP:0012880)2.53600340
29Medial flaring of the eyebrow (HP:0010747)2.51074475
30Acute necrotizing encephalopathy (HP:0006965)2.50504982
31Decreased central vision (HP:0007663)2.47278932
32Abnormal spermatogenesis (HP:0008669)2.44434338
33Abnormality of glycine metabolism (HP:0010895)2.43633010
34Abnormality of serine family amino acid metabolism (HP:0010894)2.43633010
35Abnormality of the renal medulla (HP:0100957)2.38201359
36Abnormality of cells of the erythroid lineage (HP:0012130)2.33728369
37Congenital primary aphakia (HP:0007707)2.32049986
38Partial duplication of the phalanx of hand (HP:0009999)2.31037007
39Maternal diabetes (HP:0009800)2.30536037
40Duplication of thumb phalanx (HP:0009942)2.27612852
41Poor coordination (HP:0002370)2.27288741
42Abnormality of the renal collecting system (HP:0004742)2.24074878
43Nephronophthisis (HP:0000090)2.23940755
44Pancreatic fibrosis (HP:0100732)2.23298490
45Nephrogenic diabetes insipidus (HP:0009806)2.19840039
46Chromsome breakage (HP:0040012)2.18212057
47Duplicated collecting system (HP:0000081)2.18104791
48Gait imbalance (HP:0002141)2.17383560
49Occipital encephalocele (HP:0002085)2.16986186
50Abnormality of chromosome stability (HP:0003220)2.16968746
51Optic nerve hypoplasia (HP:0000609)2.16442759
52Progressive macrocephaly (HP:0004481)2.13829994
53Abnormality of the corticospinal tract (HP:0002492)2.11664635
54Abnormal mitochondria in muscle tissue (HP:0008316)2.11220910
55Septo-optic dysplasia (HP:0100842)2.09532200
56Absent thumb (HP:0009777)2.08422325
57Macrocytic anemia (HP:0001972)2.08031486
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06678745
59Abnormal number of erythroid precursors (HP:0012131)2.05539065
60Abnormality of the vitamin B12 metabolism (HP:0004341)2.05438128
61Amyotrophic lateral sclerosis (HP:0007354)2.05434472
62Woolly hair (HP:0002224)2.04923147
63Colon cancer (HP:0003003)2.03646258
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.03510588
65Delayed CNS myelination (HP:0002188)1.98850963
663-Methylglutaconic aciduria (HP:0003535)1.95827742
67Abnormality of serum amino acid levels (HP:0003112)1.94802861
68Abnormality of vitamin B metabolism (HP:0004340)1.93276569
69Hypoplasia of the radius (HP:0002984)1.93117703
70Slow-growing hair (HP:0002217)1.92916992
71Abnormality of hair growth rate (HP:0011363)1.92916992
72Type II lissencephaly (HP:0007260)1.91759068
73Respiratory difficulties (HP:0002880)1.90474672
74Optic nerve coloboma (HP:0000588)1.90069855
75Pancreatic cysts (HP:0001737)1.89650890
76Small intestinal stenosis (HP:0012848)1.87945230
77Duodenal stenosis (HP:0100867)1.87945230
78Capillary hemangiomas (HP:0005306)1.86958805
79Lipid accumulation in hepatocytes (HP:0006561)1.86847080
80Oculomotor apraxia (HP:0000657)1.86523696
81Increased CSF lactate (HP:0002490)1.86023128
82Meckel diverticulum (HP:0002245)1.84779587
83Abnormality of the preputium (HP:0100587)1.83944406
84Abnormality of vitamin metabolism (HP:0100508)1.83894069
85Congenital stationary night blindness (HP:0007642)1.83667976
86Gonadotropin excess (HP:0000837)1.82418700
87Neoplasm of the tracheobronchial system (HP:0100552)1.82184815
88Abnormality of the ileum (HP:0001549)1.82065066
89Alveolar cell carcinoma (HP:0006519)1.80748406
90Oral leukoplakia (HP:0002745)1.80149511
91Abnormal biliary tract physiology (HP:0012439)1.79420470
92Bile duct proliferation (HP:0001408)1.79420470
93Acanthocytosis (HP:0001927)1.78517874
94Cerebral edema (HP:0002181)1.78384740
95Genital tract atresia (HP:0001827)1.78362057
96True hermaphroditism (HP:0010459)1.77978814
97Mitochondrial inheritance (HP:0001427)1.76330427
98Truncal obesity (HP:0001956)1.75020305
99Sparse eyelashes (HP:0000653)1.74333041
100Renal cortical cysts (HP:0000803)1.72107328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.66619494
2PNCK4.61007333
3STK38L3.00250392
4BRAF2.90659201
5PLK42.52973410
6PDK22.46085566
7NME12.37428921
8ZAK2.36525099
9CDK192.20381201
10EIF2AK32.16343454
11TNIK2.15599485
12WNK42.05724249
13OXSR11.96592565
14LATS11.89603805
15NLK1.87467076
16TAF11.78486796
17PINK11.75010603
18WNK31.71696419
19TTK1.70367103
20RPS6KA41.65338812
21BUB11.59937520
22NUAK11.59602754
23DYRK21.55989547
24BRD41.52004076
25CDK31.44875257
26PBK1.41406630
27MET1.39530935
28STK31.34021021
29WEE11.25087384
30STK391.23346084
31FRK1.19604751
32CDC71.17919279
33BMPR1B1.15923124
34PLK21.13239225
35VRK21.11233157
36MKNK21.04978013
37CAMK1G1.00266624
38SGK20.98132156
39WNK10.97920830
40MST1R0.97883261
41MST40.92670715
42ADRBK20.90304150
43SGK4940.90096561
44SGK2230.90096561
45DYRK30.88743607
46INSRR0.86167979
47VRK10.86150308
48BMX0.84755935
49GRK10.84229979
50MAPKAPK30.83159359
51PLK10.81040436
52TRIM280.77059540
53MAPK130.75130563
54MAP3K40.73471391
55SGK10.70454424
56KSR10.69175704
57ATM0.67003497
58CSNK2A20.64815209
59NEK20.64590389
60TYRO30.62573414
61ERBB20.61064363
62AURKB0.61029014
63RPS6KA50.59434047
64PRKCI0.59367098
65CAMK10.59206821
66CHEK10.58164433
67MKNK10.55363904
68GRK70.52299079
69AURKA0.51245542
70CSNK1E0.50572668
71MAP3K130.50218115
72NEK60.48730337
73ATR0.48223515
74CHEK20.48161889
75CSNK2A10.47304356
76STK380.45647054
77FGFR10.43797168
78TIE10.42338691
79MAP3K50.42126766
80ADRBK10.41876777
81NEK10.41857813
82STK160.39161512
83RPS6KB10.38015850
84PLK30.37675017
85BRSK20.36829817
86PRKCE0.35462053
87FGFR30.34929087
88TLK10.34437842
89PTK2B0.33195205
90TAOK30.32329253
91EIF2AK10.29148282
92NTRK30.28648359
93MAP3K20.28084472
94PRKACB0.25532749
95CDK80.25520170
96CDK10.23922273
97PASK0.23843952
98PDGFRB0.23398800
99STK100.23253683
100CDK20.23023842

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.88921131
2Proteasome_Homo sapiens_hsa030503.61027652
3Oxidative phosphorylation_Homo sapiens_hsa001903.13151039
4Mismatch repair_Homo sapiens_hsa034303.11371429
5Homologous recombination_Homo sapiens_hsa034402.86749950
6Parkinsons disease_Homo sapiens_hsa050122.65302790
7RNA transport_Homo sapiens_hsa030132.56015132
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54684430
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51037155
10Selenocompound metabolism_Homo sapiens_hsa004502.50723173
11Basal transcription factors_Homo sapiens_hsa030222.36074958
12Propanoate metabolism_Homo sapiens_hsa006402.09750965
13RNA degradation_Homo sapiens_hsa030182.06979072
14Fanconi anemia pathway_Homo sapiens_hsa034601.96793540
15Huntingtons disease_Homo sapiens_hsa050161.94142145
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89050970
17RNA polymerase_Homo sapiens_hsa030201.78291484
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.76029838
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.74927278
20Alzheimers disease_Homo sapiens_hsa050101.74732930
21One carbon pool by folate_Homo sapiens_hsa006701.74560444
22Spliceosome_Homo sapiens_hsa030401.72513391
23Oocyte meiosis_Homo sapiens_hsa041141.67279956
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67145354
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66918313
26Butanoate metabolism_Homo sapiens_hsa006501.65574077
27Fatty acid biosynthesis_Homo sapiens_hsa000611.63822286
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61729454
29Nucleotide excision repair_Homo sapiens_hsa034201.57286428
30Non-homologous end-joining_Homo sapiens_hsa034501.43029089
31DNA replication_Homo sapiens_hsa030301.40969318
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34325141
33Cardiac muscle contraction_Homo sapiens_hsa042601.28887495
34Circadian rhythm_Homo sapiens_hsa047101.28732247
35Olfactory transduction_Homo sapiens_hsa047401.24288170
36Chemical carcinogenesis_Homo sapiens_hsa052041.18892338
37mRNA surveillance pathway_Homo sapiens_hsa030151.18764870
38Protein export_Homo sapiens_hsa030601.14521736
39Caffeine metabolism_Homo sapiens_hsa002321.11758792
40Linoleic acid metabolism_Homo sapiens_hsa005911.08660772
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08188000
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04634235
43Cell cycle_Homo sapiens_hsa041101.03285969
44Phenylalanine metabolism_Homo sapiens_hsa003601.03061682
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97025029
46Sulfur metabolism_Homo sapiens_hsa009200.94367444
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93388084
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91424964
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86868136
50Vitamin digestion and absorption_Homo sapiens_hsa049770.85446502
51Purine metabolism_Homo sapiens_hsa002300.84591086
52Phototransduction_Homo sapiens_hsa047440.83820617
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.81674186
54Regulation of autophagy_Homo sapiens_hsa041400.81557423
55Tyrosine metabolism_Homo sapiens_hsa003500.80733783
56Retinol metabolism_Homo sapiens_hsa008300.77110519
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69331947
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67761256
59Glutathione metabolism_Homo sapiens_hsa004800.67343717
60Metabolic pathways_Homo sapiens_hsa011000.66694475
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65332596
62ABC transporters_Homo sapiens_hsa020100.62718392
63Fatty acid metabolism_Homo sapiens_hsa012120.61153766
64beta-Alanine metabolism_Homo sapiens_hsa004100.60115960
65Peroxisome_Homo sapiens_hsa041460.59038507
66Starch and sucrose metabolism_Homo sapiens_hsa005000.58545621
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.58439399
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58371628
69Pyrimidine metabolism_Homo sapiens_hsa002400.55822413
70Fat digestion and absorption_Homo sapiens_hsa049750.55054267
71Thyroid cancer_Homo sapiens_hsa052160.54511596
72Nitrogen metabolism_Homo sapiens_hsa009100.52590894
73Ether lipid metabolism_Homo sapiens_hsa005650.48106625
74Base excision repair_Homo sapiens_hsa034100.47249224
75Taste transduction_Homo sapiens_hsa047420.46855760
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45994916
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45230870
78Tryptophan metabolism_Homo sapiens_hsa003800.44265928
79Fatty acid degradation_Homo sapiens_hsa000710.41848282
80Pyruvate metabolism_Homo sapiens_hsa006200.41610450
81Serotonergic synapse_Homo sapiens_hsa047260.37786064
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37471144
83Nicotine addiction_Homo sapiens_hsa050330.37237728
84Basal cell carcinoma_Homo sapiens_hsa052170.35159097
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35107990
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34368126
87Arginine and proline metabolism_Homo sapiens_hsa003300.33131214
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.32993053
89Mineral absorption_Homo sapiens_hsa049780.31286359
90Protein digestion and absorption_Homo sapiens_hsa049740.29049253
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28779191
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27866495
93Glycerolipid metabolism_Homo sapiens_hsa005610.27490262
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26181843
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24769107
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23936646
97Melanoma_Homo sapiens_hsa052180.22717924
98Glutamatergic synapse_Homo sapiens_hsa047240.21641926
99p53 signaling pathway_Homo sapiens_hsa041150.21099670
100Arachidonic acid metabolism_Homo sapiens_hsa005900.19913673

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