CT47A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents a member of the cancer/testis gene family 47. This family, also known as CT47, is comprised of 13 nearly identical loci clustered at Xq24. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenylpropanoid metabolic process (GO:0009698)8.36478447
2urea metabolic process (GO:0019627)8.34054878
3urea cycle (GO:0000050)8.08372107
4nitrogen cycle metabolic process (GO:0071941)7.56994782
5regulation of fibrinolysis (GO:0051917)7.51373682
6serine family amino acid catabolic process (GO:0009071)7.47197366
7protein carboxylation (GO:0018214)7.46884259
8peptidyl-glutamic acid carboxylation (GO:0017187)7.46884259
9negative regulation of fibrinolysis (GO:0051918)7.22023827
10L-phenylalanine catabolic process (GO:0006559)7.02246754
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.02246754
12regulation of protein activation cascade (GO:2000257)6.94092181
13oxidative demethylation (GO:0070989)6.55156792
14regulation of triglyceride catabolic process (GO:0010896)6.48806439
15bile acid biosynthetic process (GO:0006699)6.43530289
16L-phenylalanine metabolic process (GO:0006558)6.43149668
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.43149668
18blood coagulation, intrinsic pathway (GO:0007597)6.39159568
19glycine metabolic process (GO:0006544)6.38117496
20drug catabolic process (GO:0042737)6.34679710
21hormone catabolic process (GO:0042447)6.24560013
22complement activation, alternative pathway (GO:0006957)6.05148850
23regulation of complement activation (GO:0030449)5.93024916
24fibrinolysis (GO:0042730)5.92872927
25alkaloid metabolic process (GO:0009820)5.79685068
26sulfur amino acid catabolic process (GO:0000098)5.75036842
27steroid catabolic process (GO:0006706)5.70245280
28bile acid metabolic process (GO:0008206)5.67704859
29serine family amino acid metabolic process (GO:0009069)5.62884025
30regulation of bile acid biosynthetic process (GO:0070857)5.45928187
31epoxygenase P450 pathway (GO:0019373)5.37622262
32cellular glucuronidation (GO:0052695)5.36041815
33arginine metabolic process (GO:0006525)5.30982355
34bile acid and bile salt transport (GO:0015721)5.17528900
35glucuronate metabolic process (GO:0019585)5.16884852
36uronic acid metabolic process (GO:0006063)5.16884852
37triglyceride homeostasis (GO:0070328)5.01845323
38acylglycerol homeostasis (GO:0055090)5.01845323
39drug metabolic process (GO:0017144)4.97346203
40regulation of lipoprotein particle clearance (GO:0010984)4.94972455
41serine family amino acid biosynthetic process (GO:0009070)4.92974251
42proline metabolic process (GO:0006560)4.85115193
43regulation of cholesterol esterification (GO:0010872)4.76958175
44positive regulation of triglyceride lipase activity (GO:0061365)4.71912256
45positive regulation of lipoprotein lipase activity (GO:0051006)4.71912256
46negative regulation of complement activation (GO:0045916)4.71161043
47negative regulation of cholesterol transport (GO:0032375)4.55076804
48negative regulation of sterol transport (GO:0032372)4.55076804
49aldehyde catabolic process (GO:0046185)4.53468193
50negative regulation of blood coagulation (GO:0030195)4.50191190
51negative regulation of hemostasis (GO:1900047)4.50191190
52cysteine metabolic process (GO:0006534)4.48750764
53negative regulation of protein activation cascade (GO:2000258)4.44573918
54drug transmembrane transport (GO:0006855)4.43537755
55regulation of sequestering of triglyceride (GO:0010889)4.39705384
56regulation of plasminogen activation (GO:0010755)4.37688458
57phospholipid efflux (GO:0033700)4.32643409
58heme transport (GO:0015886)4.26832659
59negative regulation of wound healing (GO:0061045)4.26521787
60protein activation cascade (GO:0072376)4.19628442
61L-serine metabolic process (GO:0006563)4.17409429
62cholesterol catabolic process (GO:0006707)4.11904237
63sterol catabolic process (GO:0016127)4.11904237
64negative regulation of coagulation (GO:0050819)4.09010795
65retinal metabolic process (GO:0042574)4.03031997
66arginine catabolic process (GO:0006527)4.02111116
67pyrimidine nucleobase catabolic process (GO:0006208)3.92736533
68plasma lipoprotein particle remodeling (GO:0034369)3.92355712
69protein-lipid complex remodeling (GO:0034368)3.92355712
70macromolecular complex remodeling (GO:0034367)3.92355712
71aromatic amino acid family catabolic process (GO:0009074)3.90706474
72negative regulation of lipase activity (GO:0060192)3.89688252
73very-low-density lipoprotein particle assembly (GO:0034379)3.89296727
74amino-acid betaine metabolic process (GO:0006577)3.86027705
75cofactor catabolic process (GO:0051187)3.81977065
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.81363383
77regulation of humoral immune response (GO:0002920)3.77325170
78complement activation (GO:0006956)3.77058259
79midgut development (GO:0007494)3.73767798
80alpha-amino acid catabolic process (GO:1901606)3.71831287
81negative regulation of humoral immune response (GO:0002921)3.70371318
82glutamine family amino acid catabolic process (GO:0009065)3.68250140
83cellular aldehyde metabolic process (GO:0006081)3.67583595
84positive regulation of blood coagulation (GO:0030194)3.64828041
85positive regulation of hemostasis (GO:1900048)3.64828041
86acute-phase response (GO:0006953)3.61884697
87regulation of lipoprotein metabolic process (GO:0050746)3.56569112
88diterpenoid biosynthetic process (GO:0016102)3.55108049
89drug transport (GO:0015893)3.52648254
90omega-hydroxylase P450 pathway (GO:0097267)3.50546329
91dopamine biosynthetic process (GO:0042416)3.50086345
92acute inflammatory response (GO:0002526)3.49485725
93cellular amino acid catabolic process (GO:0009063)3.44830714
94polyketide metabolic process (GO:0030638)3.44794091
95doxorubicin metabolic process (GO:0044598)3.44794091
96daunorubicin metabolic process (GO:0044597)3.44794091
97complement activation, classical pathway (GO:0006958)3.44107545
98carnitine metabolic process (GO:0009437)3.41954086
99NADH metabolic process (GO:0006734)3.37070937
100glyoxylate metabolic process (GO:0046487)11.9363296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse8.09719410
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.07357059
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.68515028
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.82959197
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.81382123
6CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.78085267
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.71537478
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.36586607
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.32008698
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.71555574
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.24308397
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4957129
13HNF4A_19822575_ChIP-Seq_HepG2_Human1.96883466
14HTT_18923047_ChIP-ChIP_STHdh_Human1.78583956
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78306778
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63637622
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60818924
18CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.58962705
19GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.58501331
20SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53135306
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.48961978
22GATA6_21074721_ChIP-Seq_CACO-2_Human1.48446226
23PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.44416033
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43944636
25RXRA_24833708_ChIP-Seq_LIVER_Mouse1.40102206
26PHF8_20622853_ChIP-Seq_HELA_Human1.34851678
27HNFA_21074721_ChIP-Seq_CACO-2_Human1.30209771
28EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.28477742
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.24555442
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22957902
31ER_23166858_ChIP-Seq_MCF-7_Human1.15835232
32RBPJ_21746931_ChIP-Seq_IB4_Human1.12622337
33SOX2_21211035_ChIP-Seq_LN229_Human1.11421623
34NFYA_21822215_ChIP-Seq_K562_Human1.10573227
35P53_21459846_ChIP-Seq_SAOS-2_Human1.09901163
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06925042
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05723349
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05109128
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04308080
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.03841667
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.02664828
42ETV1_20927104_ChIP-Seq_GIST48_Human1.02571987
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01817578
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01768743
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01055271
46ERA_21632823_ChIP-Seq_H3396_Human1.00366035
47GATA3_21867929_ChIP-Seq_CD8_Mouse0.99994208
48AR_20517297_ChIP-Seq_VCAP_Human0.98958718
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98849182
50BP1_19119308_ChIP-ChIP_Hs578T_Human0.95103017
51NCOR_22424771_ChIP-Seq_293T_Human0.92830931
52ESR1_20079471_ChIP-ChIP_T-47D_Human0.92629261
53JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92602992
54CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92064984
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91812447
56PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.90970873
57RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90331597
58ELF1_20517297_ChIP-Seq_JURKAT_Human0.89440862
59SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87857829
60FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85449538
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85088178
62NFYB_21822215_ChIP-Seq_K562_Human0.84667737
63GATA3_21878914_ChIP-Seq_MCF-7_Human0.83940033
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82552272
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81157018
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79487349
67SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78649061
68CTCF_20526341_ChIP-Seq_ESCs_Human0.78275170
69OCT4_21477851_ChIP-Seq_ESCs_Mouse0.77552380
70ESRRB_18555785_Chip-Seq_ESCs_Mouse0.77334649
71E2F1_20622854_ChIP-Seq_HELA_Human0.76783731
72CRX_20693478_ChIP-Seq_RETINA_Mouse0.74650180
73IGF1R_20145208_ChIP-Seq_DFB_Human0.74453757
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74434531
75YY1_22570637_ChIP-Seq_MALME-3M_Human0.74328938
76P300_27268052_Chip-Seq_Bcells_Human0.74132443
77RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72840680
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72502349
79SA1_27219007_Chip-Seq_Bcells_Human0.72341453
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71737199
81PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71671660
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.71577320
83ZFX_18555785_Chip-Seq_ESCs_Mouse0.69970101
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69626289
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.69464899
86SMAD1_18555785_Chip-Seq_ESCs_Mouse0.69383006
87NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.69365439
88RAC3_21632823_ChIP-Seq_H3396_Human0.68659041
89BCOR_27268052_Chip-Seq_Bcells_Human0.68468013
90CTCF_21964334_Chip-Seq_Bcells_Human0.67767097
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67227313
92SOX2_20726797_ChIP-Seq_SW620_Human0.66527350
93GATA4_25053715_ChIP-Seq_YYC3_Human0.64802356
94KLF4_18555785_Chip-Seq_ESCs_Mouse0.64266444
95PU1_27457419_Chip-Seq_LIVER_Mouse0.63879313
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.63581932
97NANOG_19829295_ChIP-Seq_ESCs_Human0.62753859
98SOX2_19829295_ChIP-Seq_ESCs_Human0.62753859
99IRF1_19129219_ChIP-ChIP_H3396_Human0.62581322
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.62038843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.22745368
2MP0005360_urolithiasis7.65708281
3MP0002138_abnormal_hepatobiliary_system6.92813912
4MP0005085_abnormal_gallbladder_physiolo5.96981985
5MP0003868_abnormal_feces_composition5.86140059
6MP0009697_abnormal_copulation5.72242658
7MP0005365_abnormal_bile_salt5.11528893
8MP0003195_calcinosis4.23979570
9MP0002876_abnormal_thyroid_physiology3.39649644
10MP0008875_abnormal_xenobiotic_pharmacok3.31968418
11MP0003806_abnormal_nucleotide_metabolis3.31760935
12MP0003252_abnormal_bile_duct3.04441361
13MP0001666_abnormal_nutrient_absorption2.77001205
14MP0001764_abnormal_homeostasis2.49398238
15MP0004019_abnormal_vitamin_homeostasis2.08333013
16MP0010329_abnormal_lipoprotein_level1.85105375
17MP0005332_abnormal_amino_acid1.85072681
18MP0009840_abnormal_foam_cell1.82865652
19MP0005187_abnormal_penis_morphology1.68245746
20MP0010386_abnormal_urinary_bladder1.56134412
21MP0003186_abnormal_redox_activity1.46960599
22MP0002118_abnormal_lipid_homeostasis1.33056694
23MP0000609_abnormal_liver_physiology1.31220060
24MP0005408_hypopigmentation1.29608636
25MP0002090_abnormal_vision1.16120279
26MP0001915_intracranial_hemorrhage1.13351365
27MP0005058_abnormal_lysosome_morphology0.94157624
28MP0005319_abnormal_enzyme/_coenzyme0.93903762
29MP0005645_abnormal_hypothalamus_physiol0.90913952
30MP0000598_abnormal_liver_morphology0.90176202
31MP0003638_abnormal_response/metabolism_0.87063266
32MP0005376_homeostasis/metabolism_phenot0.86444097
33MP0009643_abnormal_urine_homeostasis0.79023171
34MP0000604_amyloidosis0.78627469
35MP0002928_abnormal_bile_duct0.78041900
36MP0005584_abnormal_enzyme/coenzyme_acti0.77818471
37MP0005395_other_phenotype0.75033029
38MP0002132_abnormal_respiratory_system0.74071306
39MP0005636_abnormal_mineral_homeostasis0.68688686
40MP0009642_abnormal_blood_homeostasis0.68234648
41MP0003959_abnormal_lean_body0.65294352
42MP0006036_abnormal_mitochondrial_physio0.63751675
43MP0002822_catalepsy0.63219666
44MP0003191_abnormal_cellular_cholesterol0.55089789
45MP0008874_decreased_physiological_sensi0.53109781
46MP0005410_abnormal_fertilization0.53076435
47MP0002089_abnormal_postnatal_growth/wei0.51890464
48MP0001986_abnormal_taste_sensitivity0.50336365
49MP0008469_abnormal_protein_level0.48381410
50MP0002168_other_aberrant_phenotype0.48182865
51MP0009672_abnormal_birth_weight0.47878460
52MP0009053_abnormal_anal_canal0.47655456
53MP0005266_abnormal_metabolism0.41578215
54MP0005167_abnormal_blood-brain_barrier0.41432754
55MP0001661_extended_life_span0.40668548
56MP0009763_increased_sensitivity_to0.40451978
57MP0005535_abnormal_body_temperature0.40049016
58MP0001243_abnormal_dermal_layer0.39795527
59MP0003718_maternal_effect0.38639144
60MP0003879_abnormal_hair_cell0.38354101
61MP0005464_abnormal_platelet_physiology0.38179133
62MP0000249_abnormal_blood_vessel0.37087854
63MP0002971_abnormal_brown_adipose0.34782606
64MP0005197_abnormal_uvea_morphology0.32144797
65MP0003690_abnormal_glial_cell0.30414456
66MP0001324_abnormal_eye_pigmentation0.29528030
67MP0002078_abnormal_glucose_homeostasis0.29477571
68MP0003698_abnormal_male_reproductive0.27788209
69MP0002161_abnormal_fertility/fecundity0.25297032
70MP0008873_increased_physiological_sensi0.25236754
71MP0003953_abnormal_hormone_level0.25129716
72MP0001929_abnormal_gametogenesis0.24019874
73MP0001440_abnormal_grooming_behavior0.23087530
74MP0003941_abnormal_skin_development0.21812958
75MP0002938_white_spotting0.21176108
76MP0000462_abnormal_digestive_system0.21075361
77MP0001845_abnormal_inflammatory_respons0.20800896
78MP0004272_abnormal_basement_membrane0.19444973
79MP0003699_abnormal_female_reproductive0.19138942
80MP0006035_abnormal_mitochondrial_morpho0.15945810
81MP0002060_abnormal_skin_morphology0.15927532
82MP0003646_muscle_fatigue0.15673735
83MP0005083_abnormal_biliary_tract0.15091432
84MP0000653_abnormal_sex_gland0.14907099
85MP0002970_abnormal_white_adipose0.14169705
86MP0004233_abnormal_muscle_weight0.13997619
87MP0003011_delayed_dark_adaptation0.13997518
88MP0000367_abnormal_coat/_hair0.13954786
89MP0002136_abnormal_kidney_physiology0.13901833
90MP0002160_abnormal_reproductive_system0.12884191
91MP0005334_abnormal_fat_pad0.12856440
92MP0000003_abnormal_adipose_tissue0.11302770
93MP0008872_abnormal_physiological_respon0.10809391
94MP0008877_abnormal_DNA_methylation0.10444498
95MP0002697_abnormal_eye_size0.08582991
96MP0005452_abnormal_adipose_tissue0.08410501
97MP0009115_abnormal_fat_cell0.08316908
98MP0005164_abnormal_response_to0.08200429
99MP0000678_abnormal_parathyroid_gland0.07872066
100MP0002249_abnormal_larynx_morphology0.07417316

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)8.53086563
2Abnormality of pyrimidine metabolism (HP:0004353)7.51067501
3Hypobetalipoproteinemia (HP:0003563)7.27997978
4Reduced antithrombin III activity (HP:0001976)6.50028454
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.15146623
6Intrahepatic cholestasis (HP:0001406)5.78163851
7Cholecystitis (HP:0001082)5.47157442
8Abnormal gallbladder physiology (HP:0012438)5.47157442
9Joint hemorrhage (HP:0005261)5.03267997
10Hyperlipoproteinemia (HP:0010980)4.64288392
11Complement deficiency (HP:0004431)4.62340841
12Systemic lupus erythematosus (HP:0002725)4.52599118
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.38139579
14Generalized aminoaciduria (HP:0002909)4.12689328
15Glomerulonephritis (HP:0000099)4.01584542
16Hypolipoproteinemia (HP:0010981)3.97155192
17Osteomalacia (HP:0002749)3.89792562
18Hyperammonemia (HP:0001987)3.89040980
19Abnormality of nucleobase metabolism (HP:0010932)3.61182790
20Abnormal pupillary function (HP:0007686)3.59075975
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.59050821
22Bile duct proliferation (HP:0001408)3.57430792
23Abnormal biliary tract physiology (HP:0012439)3.57430792
24Xanthomatosis (HP:0000991)3.53527230
25Abnormality of complement system (HP:0005339)3.49167226
26Delayed CNS myelination (HP:0002188)3.15815626
27Abnormality of the common coagulation pathway (HP:0010990)3.13803788
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.10572428
29Abnormality of serum amino acid levels (HP:0003112)3.07879693
30Pulmonary embolism (HP:0002204)2.96928956
31Sensorimotor neuropathy (HP:0007141)2.94650161
32Menorrhagia (HP:0000132)2.89943623
33Elevated alkaline phosphatase (HP:0003155)2.85722249
34Metabolic acidosis (HP:0001942)2.81901205
35Hypoalphalipoproteinemia (HP:0003233)2.81650366
36Hyperglycinemia (HP:0002154)2.75032677
37Cholelithiasis (HP:0001081)2.66151978
38Abnormality of alkaline phosphatase activity (HP:0004379)2.60446216
39Abnormal enzyme/coenzyme activity (HP:0012379)2.55975463
40Abnormal gallbladder morphology (HP:0012437)2.50720104
41Abnormality of urine glucose concentration (HP:0011016)2.47253143
42Glycosuria (HP:0003076)2.47253143
43Cerebral edema (HP:0002181)2.44434394
44Hyperphosphaturia (HP:0003109)2.43663040
45Irritability (HP:0000737)2.38617280
46Recurrent gram-negative bacterial infections (HP:0005420)2.38191591
47Fat malabsorption (HP:0002630)2.37219326
48Atrioventricular block (HP:0001678)2.36303994
49Abnormality of fatty-acid metabolism (HP:0004359)2.34940051
50Abnormality of the Achilles tendon (HP:0005109)2.25642198
51Lethargy (HP:0001254)2.25006811
52Conjugated hyperbilirubinemia (HP:0002908)2.24880246
53Hemorrhage of the eye (HP:0011885)2.24638759
54Fair hair (HP:0002286)2.23069524
55Purpura (HP:0000979)2.21235582
56Abnormality of the intrinsic pathway (HP:0010989)2.19068977
57Alkalosis (HP:0001948)2.15681231
58Nephritis (HP:0000123)2.15438949
59Gangrene (HP:0100758)2.14314861
60Spontaneous abortion (HP:0005268)2.13425002
61Decreased subcutaneous fat (HP:0001002)2.11666987
62Gingival bleeding (HP:0000225)2.11288523
63Arthropathy (HP:0003040)2.09942400
64Abnormal urine phosphate concentration (HP:0012599)2.08054278
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07987181
66Increased serum ferritin (HP:0003281)2.05806146
67Abnormality of methionine metabolism (HP:0010901)2.04698790
68Potter facies (HP:0002009)2.04151557
69Facial shape deformation (HP:0011334)2.04151557
70Abnormality of the gallbladder (HP:0005264)2.02859157
71Hyperbilirubinemia (HP:0002904)2.01485417
72Abnormality of glycine metabolism (HP:0010895)2.01159786
73Abnormality of serine family amino acid metabolism (HP:0010894)2.01159786
74Deep venous thrombosis (HP:0002625)12.7234608
75Abnormality of monocarboxylic acid metabolism (HP:0010996)10.5341940
76Lower limb hyperreflexia (HP:0002395)1.98621713
77Beaking of vertebral bodies (HP:0004568)1.96538882
78Epidermoid cyst (HP:0200040)1.96482875
79Abnormality of the lower motor neuron (HP:0002366)1.95102969
80Steatorrhea (HP:0002570)1.94032840
81Goiter (HP:0000853)1.92412574
82Paraparesis (HP:0002385)1.92123492
83Retinal atrophy (HP:0001105)1.89274084
84Rickets (HP:0002748)1.87967440
85Prolonged neonatal jaundice (HP:0006579)1.86970253
86Abnormality of carpal bone ossification (HP:0006257)1.84729527
87Increased serum pyruvate (HP:0003542)1.84416452
88Abnormality of sulfur amino acid metabolism (HP:0004339)1.83975622
89Abnormality of purine metabolism (HP:0004352)1.82485631
90Vomiting (HP:0002013)1.81569455
91Proximal tubulopathy (HP:0000114)1.80851827
92Pancreatitis (HP:0001733)1.79481243
93Achilles tendon contracture (HP:0001771)1.75690548
94Ketosis (HP:0001946)1.75333695
95Dyskinesia (HP:0100660)1.74736737
96Widely patent fontanelles and sutures (HP:0004492)1.74695181
97Type I transferrin isoform profile (HP:0003642)1.74388269
98Polycythemia (HP:0001901)1.73031555
99Epiphyseal stippling (HP:0010655)1.67569789
100Acute encephalopathy (HP:0006846)1.67143796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG6.67393456
2PNCK4.55030553
3MET3.47789690
4BCKDK3.20166663
5MUSK2.94521751
6ARAF2.80994535
7MAP3K32.49338767
8CDK192.29685275
9MAP3K122.19864770
10PDK22.18600075
11BMX2.18499321
12TBK12.18264753
13MST1R2.13405276
14PRKCG2.11186583
15CASK2.04606889
16NEK11.89012372
17MAP2K31.77280654
18TAOK21.64158374
19PRKACG1.58187610
20TESK21.56095863
21CAMK1G1.53982249
22CDC71.53714874
23STK161.50209224
24WNK31.37184890
25ABL21.33612633
26MYLK1.23094392
27PINK11.18579562
28SGK11.15938915
29PRKCI1.14026183
30CSF1R1.11695266
31TESK11.03215305
32EIF2AK31.03208391
33BRAF1.02291833
34PTK2B1.00854372
35PIM21.00839412
36OXSR11.00503574
37MAP3K90.96861565
38PDPK10.93925693
39PRKG10.93877908
40CSNK1D0.93103334
41RIPK10.93082763
42PTK20.86355877
43TAOK30.85681724
44CDK40.81108626
45MAP2K20.80278659
46SCYL20.78985997
47FGFR40.78870661
48PRKACA0.78454736
49PRKCA0.78419854
50PRKCZ0.78253095
51FGR0.76690821
52PBK0.76662605
53GRK10.74516131
54PRPF4B0.73853690
55NEK90.71970678
56CAMKK10.71390363
57CSNK2A20.70012612
58STK38L0.66808252
59EPHA40.65908122
60MAP3K50.65602205
61DYRK20.63909824
62PLK10.63870933
63EIF2AK10.62830325
64CDK60.60639992
65CSNK2A10.57658298
66PDK10.56825547
67GRK60.55421771
68RPS6KA30.51818172
69INSRR0.50891959
70PRKCB0.50770766
71PRKCE0.50494612
72STK380.49877128
73AKT20.49733514
74LATS10.44674010
75PRKACB0.44401356
76DYRK30.43046721
77RAF10.42730691
78ERN10.40551881
79IGF1R0.36416147
80TNK20.35577185
81RPS6KA50.33445870
82PIK3CA0.32111202
83AURKA0.31655823
84CAMK2G0.30980882
85ZAK0.29761474
86MAP2K40.29723733
87CSNK1E0.29614249
88MAP3K110.29540728
89GSK3A0.29110562
90TTK0.29055378
91CDK11A0.29038420
92PLK40.28844832
93CSNK1A10.28350896
94NEK60.27688211
95MOS0.27682027
96PIM10.26804833
97CDK30.25732926
98RET0.24369291
99LIMK10.23107024
100SGK2230.22388352

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001205.10042610
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002604.09416026
3Complement and coagulation cascades_Homo sapiens_hsa046103.71617360
4Arginine biosynthesis_Homo sapiens_hsa002203.37863199
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26363159
6Steroid hormone biosynthesis_Homo sapiens_hsa001403.14247522
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.09999984
8Retinol metabolism_Homo sapiens_hsa008302.84235520
9Phenylalanine metabolism_Homo sapiens_hsa003602.74294308
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.68136484
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.66328299
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63791790
13Chemical carcinogenesis_Homo sapiens_hsa052042.49513420
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47574057
15Sulfur metabolism_Homo sapiens_hsa009202.44747425
16Bile secretion_Homo sapiens_hsa049762.34875592
17Sulfur relay system_Homo sapiens_hsa041222.18295119
18Peroxisome_Homo sapiens_hsa041462.15052440
19Drug metabolism - other enzymes_Homo sapiens_hsa009832.11577559
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77531805
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75218027
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.74258522
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.67163830
24Biosynthesis of amino acids_Homo sapiens_hsa012301.63264534
25Pyruvate metabolism_Homo sapiens_hsa006201.54749320
26Fatty acid degradation_Homo sapiens_hsa000711.51478923
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51168263
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49414226
29Linoleic acid metabolism_Homo sapiens_hsa005911.46157592
30Arginine and proline metabolism_Homo sapiens_hsa003301.44365746
31Starch and sucrose metabolism_Homo sapiens_hsa005001.44157629
32PPAR signaling pathway_Homo sapiens_hsa033201.42894581
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42348912
34beta-Alanine metabolism_Homo sapiens_hsa004101.40854687
35Histidine metabolism_Homo sapiens_hsa003401.39261058
36Tyrosine metabolism_Homo sapiens_hsa003501.37411783
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28386210
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22666364
39Tryptophan metabolism_Homo sapiens_hsa003801.15738947
40Carbon metabolism_Homo sapiens_hsa012001.10432302
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.05777920
42Arachidonic acid metabolism_Homo sapiens_hsa005901.01989569
43Butanoate metabolism_Homo sapiens_hsa006500.97128572
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88117162
45Propanoate metabolism_Homo sapiens_hsa006400.84014730
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83300954
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.82408939
48Fatty acid elongation_Homo sapiens_hsa000620.81083952
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73786515
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73501893
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.72524244
52One carbon pool by folate_Homo sapiens_hsa006700.69396830
53Fructose and mannose metabolism_Homo sapiens_hsa000510.66770422
54Steroid biosynthesis_Homo sapiens_hsa001000.65995600
55Prion diseases_Homo sapiens_hsa050200.58605803
56Staphylococcus aureus infection_Homo sapiens_hsa051500.58003658
57Fat digestion and absorption_Homo sapiens_hsa049750.56062086
58Metabolic pathways_Homo sapiens_hsa011000.56033659
59Fatty acid metabolism_Homo sapiens_hsa012120.55569204
60Caffeine metabolism_Homo sapiens_hsa002320.54203865
61Lysine degradation_Homo sapiens_hsa003100.48360588
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44297130
63Folate biosynthesis_Homo sapiens_hsa007900.42601622
64Vitamin B6 metabolism_Homo sapiens_hsa007500.41815886
65Pentose phosphate pathway_Homo sapiens_hsa000300.40555843
66Glutathione metabolism_Homo sapiens_hsa004800.40377126
67Galactose metabolism_Homo sapiens_hsa000520.33771295
68ABC transporters_Homo sapiens_hsa020100.28107690
69Vitamin digestion and absorption_Homo sapiens_hsa049770.27759018
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27477973
71Renin-angiotensin system_Homo sapiens_hsa046140.23457042
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20555762
73Other glycan degradation_Homo sapiens_hsa005110.20216966
74Serotonergic synapse_Homo sapiens_hsa047260.15334885
75Pertussis_Homo sapiens_hsa051330.10019417
76Glycerolipid metabolism_Homo sapiens_hsa005610.09146785
77Insulin resistance_Homo sapiens_hsa049310.04542356
78Glucagon signaling pathway_Homo sapiens_hsa049220.03839774
79N-Glycan biosynthesis_Homo sapiens_hsa005100.03831692
80Ovarian steroidogenesis_Homo sapiens_hsa049130.02021897
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.00851020
82Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.1730548
83AMPK signaling pathway_Homo sapiens_hsa04152-0.1660738
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1629712
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1602505
86Pyrimidine metabolism_Homo sapiens_hsa00240-0.1548910
87Amoebiasis_Homo sapiens_hsa05146-0.1425760
88Cocaine addiction_Homo sapiens_hsa05030-0.1405586
89Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1372613
90Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1222333
91Sphingolipid metabolism_Homo sapiens_hsa00600-0.1142759
92African trypanosomiasis_Homo sapiens_hsa05143-0.1082364
93Nitrogen metabolism_Homo sapiens_hsa00910-0.0949324
94Mineral absorption_Homo sapiens_hsa04978-0.0930463
95Base excision repair_Homo sapiens_hsa03410-0.0834162
96Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0636994
97Type II diabetes mellitus_Homo sapiens_hsa04930-0.0501001
98Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0482633
99alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0360459
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0116135

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