CT45A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.62680171
2ribosomal small subunit biogenesis (GO:0042274)7.55259974
3cellular glucuronidation (GO:0052695)7.53421254
4translational termination (GO:0006415)7.30407388
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.29344655
6glucuronate metabolic process (GO:0019585)7.02755607
7uronic acid metabolic process (GO:0006063)7.02755607
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.70332621
9cotranslational protein targeting to membrane (GO:0006613)6.66271269
10protein targeting to ER (GO:0045047)6.59854126
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.37709029
12protein localization to endoplasmic reticulum (GO:0070972)6.27330938
13ribosomal large subunit biogenesis (GO:0042273)6.06729864
14translational elongation (GO:0006414)6.06348509
15energy coupled proton transport, down electrochemical gradient (GO:0015985)6.01253533
16ATP synthesis coupled proton transport (GO:0015986)6.01253533
17viral life cycle (GO:0019058)5.75054780
18cellular protein complex disassembly (GO:0043624)5.67949524
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.60966768
20retinal ganglion cell axon guidance (GO:0031290)5.34727548
21translational initiation (GO:0006413)5.31520064
22daunorubicin metabolic process (GO:0044597)5.29304273
23polyketide metabolic process (GO:0030638)5.29304273
24doxorubicin metabolic process (GO:0044598)5.29304273
25retinoic acid metabolic process (GO:0042573)5.28046147
26cranial nerve development (GO:0021545)4.99179797
27protein complex disassembly (GO:0043241)4.83035956
28macromolecular complex disassembly (GO:0032984)4.70594289
29aminoglycoside antibiotic metabolic process (GO:0030647)4.69263609
30translation (GO:0006412)4.65971051
31protein targeting to membrane (GO:0006612)4.58864186
32ribonucleoprotein complex biogenesis (GO:0022613)4.57420056
33negative regulation of fatty acid metabolic process (GO:0045922)4.49665557
34RNA-dependent DNA replication (GO:0006278)4.15978443
35regulation of spindle organization (GO:0090224)3.98179644
36nuclear-transcribed mRNA catabolic process (GO:0000956)3.97849703
37cellular component biogenesis (GO:0044085)3.88811939
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.86039343
39respiratory electron transport chain (GO:0022904)3.85283760
40chaperone-mediated protein transport (GO:0072321)3.80070559
41mRNA catabolic process (GO:0006402)3.79460853
42telomere maintenance via semi-conservative replication (GO:0032201)3.77801192
43negative regulation of steroid metabolic process (GO:0045939)3.77251472
44electron transport chain (GO:0022900)3.75050942
45ribosomal small subunit assembly (GO:0000028)3.74431937
46mitotic chromosome condensation (GO:0007076)3.71825106
47transcription from mitochondrial promoter (GO:0006390)3.67398820
48protein neddylation (GO:0045116)3.61659400
49regulation of mitotic spindle organization (GO:0060236)3.59362094
50negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.53303215
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51403595
52kinetochore organization (GO:0051383)3.48495280
53protein K6-linked ubiquitination (GO:0085020)3.46616981
54establishment of integrated proviral latency (GO:0075713)3.45923490
55DNA strand elongation involved in DNA replication (GO:0006271)3.44722683
56RNA catabolic process (GO:0006401)3.42888466
57DNA strand elongation (GO:0022616)3.41931885
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41147257
59DNA replication checkpoint (GO:0000076)3.39921090
60telomere maintenance via telomerase (GO:0007004)3.39322363
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.38083218
62ATP biosynthetic process (GO:0006754)3.37758537
63regulation of cellular amino acid metabolic process (GO:0006521)3.37023100
64phenol-containing compound catabolic process (GO:0019336)3.35112512
65telomere maintenance via recombination (GO:0000722)3.33295583
66mitochondrial respiratory chain complex assembly (GO:0033108)3.30373565
67rRNA modification (GO:0000154)3.28834305
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.28070421
69parturition (GO:0007567)3.27720880
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27341818
71resolution of meiotic recombination intermediates (GO:0000712)3.24363425
72mitotic metaphase plate congression (GO:0007080)3.24233473
73proteasome assembly (GO:0043248)3.23915374
74negative regulation of response to reactive oxygen species (GO:1901032)3.21563545
75nucleobase-containing small molecule interconversion (GO:0015949)3.21001114
76nucleobase biosynthetic process (GO:0046112)3.18946750
77establishment of protein localization to membrane (GO:0090150)3.18459883
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15940408
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15156647
80negative regulation of ligase activity (GO:0051352)3.15156647
81nucleoside salvage (GO:0043174)3.11370775
82regulation of hydrogen peroxide-induced cell death (GO:1903205)3.10582918
83regulation of mitochondrial translation (GO:0070129)3.09866828
84mitotic recombination (GO:0006312)3.08956865
85ribonucleoprotein complex disassembly (GO:0032988)3.07608443
86protein targeting (GO:0006605)3.07063685
87rRNA processing (GO:0006364)3.04707350
88positive regulation of ligase activity (GO:0051351)3.04388128
89maturation of SSU-rRNA (GO:0030490)3.02688946
90ribosome biogenesis (GO:0042254)3.01959384
91formation of translation preinitiation complex (GO:0001731)3.00181441
92quinone metabolic process (GO:1901661)2.99634902
93positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.99595313
94nerve development (GO:0021675)2.97924348
95purine nucleobase biosynthetic process (GO:0009113)2.97589769
96CENP-A containing nucleosome assembly (GO:0034080)2.97281508
97purine nucleotide salvage (GO:0032261)2.93028975
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92321768
99flavonoid metabolic process (GO:0009812)11.5428698
100phenylpropanoid metabolic process (GO:0009698)11.1181005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.49258732
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.90904393
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.39221172
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.98369075
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.76631029
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.74633846
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.72352387
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.42579226
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40665082
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.39665321
11ELK1_19687146_ChIP-ChIP_HELA_Human3.36927989
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33896771
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18365595
14MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15008858
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09005274
16ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06404373
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.92223902
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89559181
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67059416
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60595871
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58718323
22VDR_23849224_ChIP-Seq_CD4+_Human2.58504660
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.46088710
24XRN2_22483619_ChIP-Seq_HELA_Human2.42980072
25E2F7_22180533_ChIP-Seq_HELA_Human2.40805489
26FOXP3_21729870_ChIP-Seq_TREG_Human2.33202179
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.32590462
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29482674
29IRF1_19129219_ChIP-ChIP_H3396_Human2.16049387
30AR_21909140_ChIP-Seq_LNCAP_Human2.12580454
31TTF2_22483619_ChIP-Seq_HELA_Human2.10965317
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08784177
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08105665
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05678221
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03634580
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00981127
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99888294
38DCP1A_22483619_ChIP-Seq_HELA_Human1.99019345
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.98784748
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94718368
41GABP_19822575_ChIP-Seq_HepG2_Human1.89696083
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.86240945
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82904576
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81220969
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76871309
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71514314
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67503537
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61717451
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61614966
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57926189
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56580942
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55134390
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50813318
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50135841
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.48349353
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48089930
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.44858374
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43616986
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39177964
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33490428
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32924402
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29108121
63KDM5A_27292631_Chip-Seq_BREAST_Human1.28296868
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28058234
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23397821
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22588311
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15306541
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13909815
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11396009
70ELF5_23300383_ChIP-Seq_T47D_Human1.10300114
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09578738
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08874835
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07070687
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06523991
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05390948
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03517114
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03447525
78MYC_18940864_ChIP-ChIP_HL60_Human1.00374641
79TFEB_21752829_ChIP-Seq_HELA_Human0.97598875
80ZNF263_19887448_ChIP-Seq_K562_Human0.96951300
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96599622
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.96280344
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92158673
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89395753
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86984350
86TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86451230
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82634559
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.80529145
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80056805
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79162215
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78973656
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78386112
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76676561
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75981626
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73598836
96SCL_19346495_ChIP-Seq_HPC-7_Human0.72533790
97GATA3_21867929_ChIP-Seq_TH1_Mouse0.72306638
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71136767
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.71136767
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.70723781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis8.78202090
2MP0002938_white_spotting7.08102082
3MP0003077_abnormal_cell_cycle3.44137450
4MP0008007_abnormal_cellular_replicative2.96033400
5MP0009697_abnormal_copulation2.71347903
6MP0004957_abnormal_blastocyst_morpholog2.56578422
7MP0003186_abnormal_redox_activity2.55898295
8MP0003693_abnormal_embryo_hatching2.49942608
9MP0008058_abnormal_DNA_repair2.43193725
10MP0010094_abnormal_chromosome_stability2.19055551
11MP0003111_abnormal_nucleus_morphology2.16921670
12MP0008875_abnormal_xenobiotic_pharmacok2.08492096
13MP0002638_abnormal_pupillary_reflex11.6828423
14MP0009379_abnormal_foot_pigmentation1.89546342
15MP0006036_abnormal_mitochondrial_physio1.87868294
16MP0003718_maternal_effect1.87615803
17MP0001853_heart_inflammation1.62972490
18MP0003941_abnormal_skin_development1.60792521
19MP0005408_hypopigmentation1.52694245
20MP0001697_abnormal_embryo_size1.32524449
21MP0008932_abnormal_embryonic_tissue1.30191961
22MP0001851_eye_inflammation1.28564602
23MP0006035_abnormal_mitochondrial_morpho1.25505606
24MP0003221_abnormal_cardiomyocyte_apopto1.22312306
25MP0008057_abnormal_DNA_replication1.21666899
26MP0005670_abnormal_white_adipose1.21268985
27MP0008877_abnormal_DNA_methylation1.14808787
28MP0000313_abnormal_cell_death1.08648871
29MP0002932_abnormal_joint_morphology1.05070631
30MP0000358_abnormal_cell_content/0.99464893
31MP0002160_abnormal_reproductive_system0.98126737
32MP0000350_abnormal_cell_proliferation0.96297216
33MP0001764_abnormal_homeostasis0.95120346
34MP0002132_abnormal_respiratory_system0.95110405
35MP0000858_altered_metastatic_potential0.94886534
36MP0000678_abnormal_parathyroid_gland0.91579165
37MP0002396_abnormal_hematopoietic_system0.91549308
38MP0002080_prenatal_lethality0.89294527
39MP0001286_abnormal_eye_development0.87750356
40MP0005330_cardiomyopathy0.86856305
41MP0002111_abnormal_tail_morphology0.86117451
42MP0001730_embryonic_growth_arrest0.84046642
43MP0004147_increased_porphyrin_level0.81055076
44MP0001881_abnormal_mammary_gland0.73821838
45MP0005266_abnormal_metabolism0.70485751
46MP0002928_abnormal_bile_duct0.68617270
47MP0000372_irregular_coat_pigmentation0.68203429
48MP0005384_cellular_phenotype0.66949555
49MP0005332_abnormal_amino_acid0.66762399
50MP0005621_abnormal_cell_physiology0.66758138
51MP0009765_abnormal_xenobiotic_induced0.66506754
52MP0005501_abnormal_skin_physiology0.65331701
53MP0003786_premature_aging0.63442825
54MP0001661_extended_life_span0.63222013
55MP0005193_abnormal_anterior_eye0.62140451
56MP0005410_abnormal_fertilization0.61872381
57MP0001905_abnormal_dopamine_level0.61237109
58MP0002019_abnormal_tumor_incidence0.59530843
59MP0005395_other_phenotype0.58328379
60MP0010030_abnormal_orbit_morphology0.57625847
61MP0005319_abnormal_enzyme/_coenzyme0.56582645
62MP0001340_abnormal_eyelid_morphology0.53897447
63MP0009780_abnormal_chondrocyte_physiolo0.52045411
64MP0005389_reproductive_system_phenotype0.52033642
65MP0002095_abnormal_skin_pigmentation0.51882926
66MP0001929_abnormal_gametogenesis0.50587238
67MP0005380_embryogenesis_phenotype0.50346560
68MP0001672_abnormal_embryogenesis/_devel0.50346560
69MP0004019_abnormal_vitamin_homeostasis0.49263484
70MP0005646_abnormal_pituitary_gland0.48896057
71MP0002210_abnormal_sex_determination0.46768607
72MP0003984_embryonic_growth_retardation0.46387558
73MP0002088_abnormal_embryonic_growth/wei0.45808820
74MP0008995_early_reproductive_senescence0.44746396
75MP0001216_abnormal_epidermal_layer0.43549254
76MP0002109_abnormal_limb_morphology0.41857767
77MP0003656_abnormal_erythrocyte_physiolo0.41628176
78MP0002796_impaired_skin_barrier0.41435775
79MP0005376_homeostasis/metabolism_phenot0.41410515
80MP0005076_abnormal_cell_differentiation0.40379823
81MP0002085_abnormal_embryonic_tissue0.40071341
82MP0005636_abnormal_mineral_homeostasis0.38916055
83MP0002086_abnormal_extraembryonic_tissu0.38224802
84MP0000627_abnormal_mammary_gland0.37839820
85MP0001529_abnormal_vocalization0.36477812
86MP0002295_abnormal_pulmonary_circulatio0.36295760
87MP0001145_abnormal_male_reproductive0.36295317
88MP0000653_abnormal_sex_gland0.36134711
89MP0002114_abnormal_axial_skeleton0.35988670
90MP0003252_abnormal_bile_duct0.35685933
91MP0005195_abnormal_posterior_eye0.34458832
92MP0003638_abnormal_response/metabolism_0.32927842
93MP0001186_pigmentation_phenotype0.32773366
94MP0000371_diluted_coat_color0.32033108
95MP0002098_abnormal_vibrissa_morphology0.31222648
96MP0000367_abnormal_coat/_hair0.31039629
97MP0004145_abnormal_muscle_electrophysio0.30867653
98MP0000377_abnormal_hair_follicle0.30374577
99MP0008873_increased_physiological_sensi0.30328423
100MP0004134_abnormal_chest_morphology0.30032389

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)6.63997614
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)6.63997614
3Abnormality of cells of the erythroid lineage (HP:0012130)6.35606038
4Stenosis of the external auditory canal (HP:0000402)6.13685946
53-Methylglutaconic aciduria (HP:0003535)6.06774305
6Macrocytic anemia (HP:0001972)5.65252098
7Abnormal mitochondria in muscle tissue (HP:0008316)4.77861723
8Acute necrotizing encephalopathy (HP:0006965)4.59081571
9Increased hepatocellular lipid droplets (HP:0006565)4.45969836
10Pallor (HP:0000980)4.35492574
11Renal Fanconi syndrome (HP:0001994)4.19354711
12Type I transferrin isoform profile (HP:0003642)4.14957637
13Acute encephalopathy (HP:0006846)4.02693343
14Lipid accumulation in hepatocytes (HP:0006561)3.91926944
15Mitochondrial inheritance (HP:0001427)3.86325773
16Increased intramyocellular lipid droplets (HP:0012240)3.85870645
17Progressive macrocephaly (HP:0004481)3.77250693
18Hypoplastic pelvis (HP:0008839)3.66264029
19Testicular atrophy (HP:0000029)3.63861037
20Increased CSF lactate (HP:0002490)3.52968737
21Abnormal number of erythroid precursors (HP:0012131)3.47661716
22Reduced antithrombin III activity (HP:0001976)3.42304374
23Hyperthyroidism (HP:0000836)3.41716247
24Abnormality of methionine metabolism (HP:0010901)3.37797545
25Generalized aminoaciduria (HP:0002909)3.28692954
26Aplasia/Hypoplasia of the sacrum (HP:0008517)3.19306881
27Increased muscle lipid content (HP:0009058)3.18310382
28Cerebral edema (HP:0002181)3.12849875
29Reticulocytopenia (HP:0001896)2.99413346
30Prolonged partial thromboplastin time (HP:0003645)2.98782773
31Abnormality of homocysteine metabolism (HP:0010919)2.93174472
32Homocystinuria (HP:0002156)2.93174472
33Exertional dyspnea (HP:0002875)2.91685693
34Abnormality of renal resorption (HP:0011038)2.88416019
35Absent thumb (HP:0009777)2.87993468
36Hepatic necrosis (HP:0002605)2.86344493
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80690029
38Abnormal protein N-linked glycosylation (HP:0012347)2.80690029
39Abnormal protein glycosylation (HP:0012346)2.80690029
40Abnormal glycosylation (HP:0012345)2.80690029
41Palpitations (HP:0001962)2.79704899
42Megaloblastic anemia (HP:0001889)2.78703150
43Neuroendocrine neoplasm (HP:0100634)2.72609109
44Decreased subcutaneous fat (HP:0001002)2.65124385
45Conjunctival hamartoma (HP:0100780)2.61316835
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59314535
47Respiratory difficulties (HP:0002880)2.54587578
48Methylmalonic acidemia (HP:0002912)2.53342872
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52807368
50Hypoparathyroidism (HP:0000829)2.50274573
51Hypertensive crisis (HP:0100735)2.48155053
52Neoplasm of the peripheral nervous system (HP:0100007)2.47726042
53Lactic acidosis (HP:0003128)2.47104533
54Aplastic anemia (HP:0001915)2.47001483
55Neoplasm of head and neck (HP:0012288)2.45376226
56Esophageal neoplasm (HP:0100751)2.45376226
57Exercise intolerance (HP:0003546)2.40895532
58Hypoplasia of the radius (HP:0002984)2.40141293
59Hepatocellular necrosis (HP:0001404)2.39925472
60Increased serum lactate (HP:0002151)2.38835549
61Abnormal hair whorl (HP:0010721)2.31353548
62Pheochromocytoma (HP:0002666)2.28478574
63Truncus arteriosus (HP:0001660)2.28271170
64Abnormality of subcutaneous fat tissue (HP:0001001)2.28194399
65Oral leukoplakia (HP:0002745)2.27003053
66Respiratory failure (HP:0002878)2.26258947
67Leukodystrophy (HP:0002415)2.26108152
68Seborrheic dermatitis (HP:0001051)2.25540646
69Abnormality of urine glucose concentration (HP:0011016)2.25509934
70Glycosuria (HP:0003076)2.25509934
71Congenital, generalized hypertrichosis (HP:0004540)2.16210838
72Poor speech (HP:0002465)2.16052125
73Small hand (HP:0200055)2.13013981
74Proximal tubulopathy (HP:0000114)2.10748620
75Lip pit (HP:0100267)2.07677317
76Tinnitus (HP:0000360)2.07370992
77Paralysis (HP:0003470)2.06025560
78Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05507578
79Patchy hypopigmentation of hair (HP:0011365)2.04880477
80Gout (HP:0001997)2.04090220
81Abnormality of the tricuspid valve (HP:0001702)1.96162758
82Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93136827
83Abnormality of sulfur amino acid metabolism (HP:0004339)1.88643515
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87082944
85Abnormality of serum amino acid levels (HP:0003112)1.86544162
86Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85507582
87Abnormality of glycolysis (HP:0004366)1.85222436
88Abnormal hemoglobin (HP:0011902)1.84418552
89Posterior subcapsular cataract (HP:0007787)1.83674861
90Increased serum pyruvate (HP:0003542)1.83326512
91Pancytopenia (HP:0001876)1.81473786
92Meningioma (HP:0002858)1.78401931
93Lethargy (HP:0001254)1.76650236
94Median cleft lip (HP:0000161)1.76310954
95Supernumerary bones of the axial skeleton (HP:0009144)1.74474154
96Chromsome breakage (HP:0040012)1.72303169
97Patent foramen ovale (HP:0001655)1.72008599
98Hyperphosphaturia (HP:0003109)1.71937119
99Rough bone trabeculation (HP:0100670)1.69970149
100Methylmalonic aciduria (HP:0012120)1.68786942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.04752061
2ARAF3.89965034
3CDC73.87044374
4MAP3K123.82325181
5EIF2AK13.79863488
6BRSK23.62947566
7PBK2.78463495
8BMPR1B2.77048963
9STK162.60187747
10PAK42.52485745
11NEK12.45916862
12SRPK12.44201410
13TTK2.38529263
14CLK12.29704782
15VRK22.26736883
16BRAF2.01143862
17PIM21.87724050
18RPS6KB21.85934963
19BUB11.85849116
20PLK41.81695452
21NME11.79454263
22MYLK1.75538979
23AURKB1.72499858
24BRSK11.62710371
25EIF2AK31.62202460
26WEE11.48149421
27AURKA1.47568086
28PLK11.37041962
29VRK11.33948691
30CDK91.26752912
31NUAK11.20077839
32RAF11.17254424
33NEK21.08433548
34STK41.06575235
35BCKDK1.06007526
36PLK31.02857186
37CSNK2A20.98699937
38TLK10.98112550
39ABL20.86864133
40PHKG20.84798987
41PHKG10.84798987
42EIF2AK20.84304909
43CHEK10.81101939
44MAP3K20.75618426
45MAP3K80.75274752
46CCNB10.71718202
47CSNK2A10.71370278
48PRKCI0.69469126
49ERBB40.68880076
50CSNK1E0.67060764
51ILK0.65088799
52CHEK20.64947699
53MARK30.62091295
54CDK70.61148864
55RIPK40.60498494
56AKT20.60418889
57RPS6KA50.60318826
58PAK20.59377817
59ZAK0.57793585
60YES10.57261656
61MST1R0.54308400
62ATR0.53501171
63PLK20.53451306
64BMPR20.53259612
65PAK10.51186774
66CDK10.50566056
67MAP3K30.49102800
68PTK20.48731766
69NME20.47162198
70ATM0.47121195
71STK100.43530797
72CDK20.42799630
73CDK80.42773947
74CSNK1G30.42245022
75PRKACB0.42195582
76TAOK30.40167340
77CSNK1D0.40082114
78CAMKK20.39710675
79RPS6KL10.39399206
80RPS6KC10.39399206
81PIM10.39204068
82PRKG20.36487674
83PDK20.36335297
84NEK90.36293184
85CSNK1A1L0.34329857
86RPS6KA60.33998246
87SGK10.31924417
88KSR20.30142760
89PTK60.29482767
90CSNK1G20.29063752
91DAPK30.28504682
92CAMK2G0.27411017
93PRKG10.26862635
94MINK10.26640169
95TNIK0.26623015
96CDK30.22309013
97STK30.20604838
98PASK0.20219458
99DAPK10.19407104
100CSNK1G10.17220938

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.49479534
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.88672189
3Pentose and glucuronate interconversions_Homo sapiens_hsa000404.56619324
4Drug metabolism - other enzymes_Homo sapiens_hsa009833.84334616
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.63386728
6Proteasome_Homo sapiens_hsa030503.31823250
7Oxidative phosphorylation_Homo sapiens_hsa001903.25049130
8Mismatch repair_Homo sapiens_hsa034303.14963295
9Protein export_Homo sapiens_hsa030603.03930795
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.94707299
11Nucleotide excision repair_Homo sapiens_hsa034202.81155747
12DNA replication_Homo sapiens_hsa030302.80308299
13Parkinsons disease_Homo sapiens_hsa050122.59769246
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.50675401
15Chemical carcinogenesis_Homo sapiens_hsa052042.27691200
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16735361
17Starch and sucrose metabolism_Homo sapiens_hsa005002.12733638
18Retinol metabolism_Homo sapiens_hsa008302.09127801
19Homologous recombination_Homo sapiens_hsa034402.05360032
20Huntingtons disease_Homo sapiens_hsa050161.86287381
21Alzheimers disease_Homo sapiens_hsa050101.86045400
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82886023
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58621700
24One carbon pool by folate_Homo sapiens_hsa006701.56783131
25Spliceosome_Homo sapiens_hsa030401.45758642
26Base excision repair_Homo sapiens_hsa034101.40927541
27Fanconi anemia pathway_Homo sapiens_hsa034601.29697060
28RNA polymerase_Homo sapiens_hsa030201.26244958
29Basal transcription factors_Homo sapiens_hsa030221.16846627
30RNA transport_Homo sapiens_hsa030131.13815528
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08712484
32Pyrimidine metabolism_Homo sapiens_hsa002401.04329773
33RNA degradation_Homo sapiens_hsa030180.95963761
34Cardiac muscle contraction_Homo sapiens_hsa042600.93975084
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86729478
36Cell cycle_Homo sapiens_hsa041100.83865931
37Glutathione metabolism_Homo sapiens_hsa004800.77368239
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74533704
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.70770180
40Fructose and mannose metabolism_Homo sapiens_hsa000510.69022792
41Folate biosynthesis_Homo sapiens_hsa007900.56062819
42Galactose metabolism_Homo sapiens_hsa000520.53649756
43Purine metabolism_Homo sapiens_hsa002300.51681712
44Oocyte meiosis_Homo sapiens_hsa041140.51121465
45Metabolic pathways_Homo sapiens_hsa011000.50916513
46N-Glycan biosynthesis_Homo sapiens_hsa005100.50004503
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47679016
48mRNA surveillance pathway_Homo sapiens_hsa030150.43661545
49Collecting duct acid secretion_Homo sapiens_hsa049660.42231968
50Mineral absorption_Homo sapiens_hsa049780.41428984
51Non-homologous end-joining_Homo sapiens_hsa034500.41267766
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40867158
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37690392
54Regulation of autophagy_Homo sapiens_hsa041400.37593102
55Tyrosine metabolism_Homo sapiens_hsa003500.36031497
56Vibrio cholerae infection_Homo sapiens_hsa051100.33680227
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33611190
58Renal cell carcinoma_Homo sapiens_hsa052110.32699275
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31763989
60Pentose phosphate pathway_Homo sapiens_hsa000300.27495930
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27484358
62Carbon metabolism_Homo sapiens_hsa012000.26485438
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25683292
64Caffeine metabolism_Homo sapiens_hsa002320.25027059
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24476868
66Propanoate metabolism_Homo sapiens_hsa006400.23878264
67Pyruvate metabolism_Homo sapiens_hsa006200.23557053
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22854849
69Circadian rhythm_Homo sapiens_hsa047100.19523280
70Vitamin digestion and absorption_Homo sapiens_hsa049770.19031815
71Epstein-Barr virus infection_Homo sapiens_hsa051690.17079278
72Sulfur metabolism_Homo sapiens_hsa009200.16512944
73Peroxisome_Homo sapiens_hsa041460.14961712
74Shigellosis_Homo sapiens_hsa051310.14500751
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.09732406
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.06833712
77HIF-1 signaling pathway_Homo sapiens_hsa040660.05795459
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.04148899
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.03828769
80Arachidonic acid metabolism_Homo sapiens_hsa005900.03746253
81Thyroid cancer_Homo sapiens_hsa052160.02036533
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.01925235
83Viral carcinogenesis_Homo sapiens_hsa05203-0.1670700
84Pathways in cancer_Homo sapiens_hsa05200-0.1666240
85Glycine, serine and threonine metabolism_Homo sapiens_hsa00260-0.1644543
86Wnt signaling pathway_Homo sapiens_hsa04310-0.1620258
87Steroid biosynthesis_Homo sapiens_hsa00100-0.1589357
88Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.1524617
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1371375
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1339920
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.1321755
92Alcoholism_Homo sapiens_hsa05034-0.1308545
93Butanoate metabolism_Homo sapiens_hsa00650-0.1299626
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0904816
95Fatty acid elongation_Homo sapiens_hsa00062-0.0837643
96Biosynthesis of amino acids_Homo sapiens_hsa01230-0.0832049
97Small cell lung cancer_Homo sapiens_hsa05222-0.0687607
98Vitamin B6 metabolism_Homo sapiens_hsa00750-0.0455326
99p53 signaling pathway_Homo sapiens_hsa04115-0.0392123
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0011668

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