CT45A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.25083197
2ribosomal small subunit biogenesis (GO:0042274)6.49716075
3formation of translation preinitiation complex (GO:0001731)6.45055189
4negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.22558099
5viral transcription (GO:0019083)5.44493405
6ribosome assembly (GO:0042255)5.43103893
7ribosomal large subunit biogenesis (GO:0042273)5.30839143
8translational termination (GO:0006415)5.25024382
9regulation of retinoic acid receptor signaling pathway (GO:0048385)5.23772883
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.90943010
11ribonucleoprotein complex biogenesis (GO:0022613)4.87678696
12cotranslational protein targeting to membrane (GO:0006613)4.77669907
13Golgi transport vesicle coating (GO:0048200)4.75469375
14COPI coating of Golgi vesicle (GO:0048205)4.75469375
15protein targeting to ER (GO:0045047)4.73721475
16nuclear pore complex assembly (GO:0051292)4.68086653
17translational elongation (GO:0006414)4.61245597
18translational initiation (GO:0006413)4.61135648
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.60303818
20mitotic chromosome condensation (GO:0007076)4.59079651
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.53831711
22gonadal mesoderm development (GO:0007506)4.51900417
23protein localization to endoplasmic reticulum (GO:0070972)4.50501698
24viral life cycle (GO:0019058)4.28428020
25ribosome biogenesis (GO:0042254)4.27041579
26cellular protein complex disassembly (GO:0043624)4.26690174
27regulation of translational fidelity (GO:0006450)4.11069863
28rRNA modification (GO:0000154)4.09244412
29nuclear pore organization (GO:0006999)3.96543685
30nucleobase-containing small molecule interconversion (GO:0015949)3.94791040
31rRNA methylation (GO:0031167)3.79288085
32protein complex disassembly (GO:0043241)3.77626814
33regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.72068636
34regulation of mitotic spindle organization (GO:0060236)3.71227491
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.68402637
36macromolecular complex disassembly (GO:0032984)3.67594041
37regulation of mammary gland epithelial cell proliferation (GO:0033599)3.65358658
38pore complex assembly (GO:0046931)3.64385853
39translation (GO:0006412)3.55028790
40protein targeting to membrane (GO:0006612)3.53319294
41maturation of SSU-rRNA (GO:0030490)3.52251188
42mitotic metaphase plate congression (GO:0007080)3.49452925
43cellular component biogenesis (GO:0044085)3.34481233
44chromosome condensation (GO:0030261)3.33277591
45mitotic sister chromatid segregation (GO:0000070)3.29171331
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25405129
47DNA unwinding involved in DNA replication (GO:0006268)3.20826946
48protein localization to chromosome, centromeric region (GO:0071459)3.17713321
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.11606758
50rRNA processing (GO:0006364)3.08289625
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08118783
52sister chromatid segregation (GO:0000819)3.06807249
53negative regulation of DNA repair (GO:0045738)3.03985540
54proline biosynthetic process (GO:0006561)3.02871958
55regulation of spindle organization (GO:0090224)3.00316662
56metaphase plate congression (GO:0051310)3.00050244
57mRNA catabolic process (GO:0006402)2.97661054
58mitochondrial fusion (GO:0008053)2.95305533
59positive regulation of cell cycle checkpoint (GO:1901978)2.92355041
60N-terminal protein amino acid acetylation (GO:0006474)2.92076421
61rRNA metabolic process (GO:0016072)2.91537345
62protein maturation by protein folding (GO:0022417)2.90881796
63DNA packaging (GO:0006323)2.90207174
64ncRNA 3-end processing (GO:0043628)2.89500312
65fusion of sperm to egg plasma membrane (GO:0007342)2.81382926
66GMP metabolic process (GO:0046037)2.80231303
67deoxyribonucleotide biosynthetic process (GO:0009263)2.79461790
68mitotic nuclear envelope disassembly (GO:0007077)2.78273488
69RNA catabolic process (GO:0006401)2.77648608
70regulation of gonadotropin secretion (GO:0032276)2.72175976
71tRNA aminoacylation for protein translation (GO:0006418)2.69985791
72T cell apoptotic process (GO:0070231)2.69764244
73regulation of translational initiation (GO:0006446)2.69719778
74regulation of RNA export from nucleus (GO:0046831)2.68301116
75ribonucleoprotein complex assembly (GO:0022618)2.66430756
76GDP-mannose metabolic process (GO:0019673)2.66116187
77protein localization to kinetochore (GO:0034501)2.65673504
78DNA replication initiation (GO:0006270)2.64473904
79UDP-N-acetylglucosamine metabolic process (GO:0006047)2.61254851
80regulation of translational elongation (GO:0006448)2.60522554
81membrane disassembly (GO:0030397)2.59893429
82nuclear envelope disassembly (GO:0051081)2.59893429
83mitotic sister chromatid cohesion (GO:0007064)2.58543923
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.58358338
85spliceosomal tri-snRNP complex assembly (GO:0000244)2.58186454
86activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.58067041
87ribonucleoprotein complex subunit organization (GO:0071826)2.57583715
88tRNA aminoacylation (GO:0043039)2.55925827
89amino acid activation (GO:0043038)2.55925827
90mitochondrial DNA metabolic process (GO:0032042)2.54804619
91maturation of 5.8S rRNA (GO:0000460)2.53789862
92cellular protein complex localization (GO:0034629)2.52513892
93establishment of protein localization to membrane (GO:0090150)2.51955474
94retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51068152
95negative regulation of necroptotic process (GO:0060546)2.50759524
96nucleotide-sugar biosynthetic process (GO:0009226)2.50710726
97establishment of chromosome localization (GO:0051303)2.50582607
98protein complex localization (GO:0031503)2.50148202
99peptidyl-proline hydroxylation (GO:0019511)2.49218577
100de novo protein folding (GO:0006458)2.47297571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.48005646
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.18136954
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51293922
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.49858996
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.49768758
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.33563809
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93974833
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93363865
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.86775085
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78350318
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73330689
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70990648
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58954383
14XRN2_22483619_ChIP-Seq_HELA_Human2.57098052
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55290868
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55029352
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52330147
18DCP1A_22483619_ChIP-Seq_HELA_Human2.41995307
19TTF2_22483619_ChIP-Seq_HELA_Human2.36486368
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36111192
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.26417998
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23228702
23ZNF263_19887448_ChIP-Seq_K562_Human2.09509443
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.09080111
25AR_21909140_ChIP-Seq_LNCAP_Human2.05127056
26ZFX_18555785_ChIP-Seq_MESCs_Mouse1.99560702
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96616924
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96188197
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92086349
30GABP_19822575_ChIP-Seq_HepG2_Human1.90909058
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.90267252
32ELK1_19687146_ChIP-ChIP_HELA_Human1.90051425
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82191444
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78441324
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78121690
36KDM5A_27292631_Chip-Seq_BREAST_Human1.71067212
37TFEB_21752829_ChIP-Seq_HELA_Human1.69883632
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68448341
39VDR_23849224_ChIP-Seq_CD4+_Human1.64520437
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64303929
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63426642
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62071916
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61178318
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57861191
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55494165
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50013494
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48779663
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48350888
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47496888
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.46910045
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45903145
52FOXP3_21729870_ChIP-Seq_TREG_Human1.45218482
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44020399
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41506121
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37416665
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37073005
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37066212
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35877107
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.35821210
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31535142
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.30967822
62MYC_22102868_ChIP-Seq_BL_Human1.30193577
63ATF3_27146783_Chip-Seq_COLON_Human1.28886583
64CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.27320778
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.26648097
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26206953
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25889995
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25886822
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25200039
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20766295
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18782613
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17635990
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17397407
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17060616
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.16806635
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16646645
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16640656
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13129954
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12714557
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11645311
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09945410
82CIITA_25753668_ChIP-Seq_RAJI_Human1.09357108
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09029392
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08388638
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05293631
86CHD1_26751641_Chip-Seq_LNCaP_Human1.05129106
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03306922
88SOX17_20123909_ChIP-Seq_XEN_Mouse1.02024304
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01816895
90RACK7_27058665_Chip-Seq_MCF-7_Human0.98493105
91NCOR1_26117541_ChIP-Seq_K562_Human0.97599287
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97129425
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96548072
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96192349
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95683776
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93152637
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92746202
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91548701
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91224428
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90313558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.95794567
2MP0005171_absent_coat_pigmentation3.87859034
3MP0004957_abnormal_blastocyst_morpholog3.58309896
4MP0003693_abnormal_embryo_hatching3.09648469
5MP0003111_abnormal_nucleus_morphology3.07526741
6MP0003077_abnormal_cell_cycle3.07250065
7MP0009697_abnormal_copulation3.03724992
8MP0001661_extended_life_span2.80661705
9MP0008932_abnormal_embryonic_tissue2.70678892
10MP0005408_hypopigmentation2.67004464
11MP0002877_abnormal_melanocyte_morpholog2.62409107
12MP0010094_abnormal_chromosome_stability2.61039843
13MP0008007_abnormal_cellular_replicative2.59958189
14MP0001348_abnormal_lacrimal_gland2.56350686
15MP0008058_abnormal_DNA_repair2.43344944
16MP0000358_abnormal_cell_content/2.31671608
17MP0010307_abnormal_tumor_latency2.20407525
18MP0004233_abnormal_muscle_weight2.05155803
19MP0000350_abnormal_cell_proliferation2.00433496
20MP0006035_abnormal_mitochondrial_morpho1.92217138
21MP0003786_premature_aging1.80212548
22MP0009379_abnormal_foot_pigmentation1.76216201
23MP0003950_abnormal_plasma_membrane1.72185100
24MP0004858_abnormal_nervous_system1.69361151
25MP0001730_embryonic_growth_arrest1.68550351
26MP0003718_maternal_effect1.56952173
27MP0004808_abnormal_hematopoietic_stem1.51901234
28MP0002080_prenatal_lethality1.51534780
29MP0003186_abnormal_redox_activity1.46104058
30MP0001697_abnormal_embryo_size1.46035538
31MP0008057_abnormal_DNA_replication1.36265690
32MP0003252_abnormal_bile_duct1.34083135
33MP0002210_abnormal_sex_determination1.33969667
34MP0001672_abnormal_embryogenesis/_devel1.33147579
35MP0005380_embryogenesis_phenotype1.33147579
36MP0000733_abnormal_muscle_development1.30768944
37MP0001929_abnormal_gametogenesis1.30377527
38MP0010030_abnormal_orbit_morphology1.27118429
39MP0003656_abnormal_erythrocyte_physiolo1.25560348
40MP0002269_muscular_atrophy1.23930633
41MP0002086_abnormal_extraembryonic_tissu1.21901868
42MP0005501_abnormal_skin_physiology1.20885572
43MP0000313_abnormal_cell_death1.20205188
44MP0003941_abnormal_skin_development1.18719835
45MP0003984_embryonic_growth_retardation1.18026182
46MP0005621_abnormal_cell_physiology1.15176152
47MP0009053_abnormal_anal_canal1.13375971
48MP0003221_abnormal_cardiomyocyte_apopto1.13188939
49MP0005384_cellular_phenotype1.12511909
50MP0001853_heart_inflammation1.10802179
51MP0002088_abnormal_embryonic_growth/wei1.09506325
52MP0005410_abnormal_fertilization1.08300427
53MP0006036_abnormal_mitochondrial_physio1.07092087
54MP0000858_altered_metastatic_potential1.05772437
55MP0002084_abnormal_developmental_patter1.04990170
56MP0000647_abnormal_sebaceous_gland1.04444650
57MP0002938_white_spotting1.03100841
58MP0003136_yellow_coat_color1.02050279
59MP0008995_early_reproductive_senescence1.00364870
60MP0003566_abnormal_cell_adhesion0.99641348
61MP0002163_abnormal_gland_morphology0.97433238
62MP0003806_abnormal_nucleotide_metabolis0.97015939
63MP0002085_abnormal_embryonic_tissue0.96479629
64MP0000627_abnormal_mammary_gland0.96109120
65MP0008438_abnormal_cutaneous_collagen0.95478451
66MP0005076_abnormal_cell_differentiation0.95378541
67MP0001145_abnormal_male_reproductive0.93847062
68MP0003943_abnormal_hepatobiliary_system0.92954975
69MP0002060_abnormal_skin_morphology0.92515243
70MP0002019_abnormal_tumor_incidence0.91166177
71MP0000003_abnormal_adipose_tissue0.90056121
72MP0000678_abnormal_parathyroid_gland0.88581841
73MP0000653_abnormal_sex_gland0.87751527
74MP0005058_abnormal_lysosome_morphology0.87679535
75MP0003698_abnormal_male_reproductive0.87042954
76MP0001881_abnormal_mammary_gland0.86971344
77MP0010368_abnormal_lymphatic_system0.86903057
78MP0002796_impaired_skin_barrier0.85434156
79MP0002075_abnormal_coat/hair_pigmentati0.84242428
80MP0010352_gastrointestinal_tract_polyps0.81646411
81MP0001186_pigmentation_phenotype0.78696035
82MP0002161_abnormal_fertility/fecundity0.78373972
83MP0003699_abnormal_female_reproductive0.78147499
84MP0004197_abnormal_fetal_growth/weight/0.78065757
85MP0000490_abnormal_crypts_of0.77725693
86MP0002928_abnormal_bile_duct0.77626252
87MP0000759_abnormal_skeletal_muscle0.77532020
88MP0002396_abnormal_hematopoietic_system0.75420618
89MP0000750_abnormal_muscle_regeneration0.73131967
90MP0009840_abnormal_foam_cell0.72077226
91MP0000639_abnormal_adrenal_gland0.69895964
92MP0008770_decreased_survivor_rate0.68103872
93MP0003959_abnormal_lean_body0.67359057
94MP0003091_abnormal_cell_migration0.66772889
95MP0004185_abnormal_adipocyte_glucose0.66551170
96MP0003385_abnormal_body_wall0.65730941
97MP0010234_abnormal_vibrissa_follicle0.65494750
98MP0003191_abnormal_cellular_cholesterol0.62939933
99MP0002089_abnormal_postnatal_growth/wei0.62815519
100MP0002009_preneoplasia0.62567413

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)4.86173404
2Spastic paraparesis (HP:0002313)4.30562347
3Abnormality of cells of the erythroid lineage (HP:0012130)4.08147832
4Upper limb muscle weakness (HP:0003484)3.74240851
5Entropion (HP:0000621)3.70282359
6Male infertility (HP:0003251)3.52933524
7Reticulocytopenia (HP:0001896)3.38389421
8Neoplasm of the peripheral nervous system (HP:0100007)3.35706746
9Syringomyelia (HP:0003396)3.34698805
10Spinal cord lesions (HP:0100561)3.34698805
11Paraparesis (HP:0002385)3.29850245
12Abnormal auditory evoked potentials (HP:0006958)3.21910602
13Patchy hypopigmentation of hair (HP:0011365)3.20396497
14White forelock (HP:0002211)2.99823944
15Hamartoma of the eye (HP:0010568)2.83929404
16Abnormal number of erythroid precursors (HP:0012131)2.81724891
17Cerebral hypomyelination (HP:0006808)2.80416215
18Poikiloderma (HP:0001029)2.69583471
19Meningioma (HP:0002858)2.67676802
20Thrombocytosis (HP:0001894)2.65369883
21Premature graying of hair (HP:0002216)2.65133539
22Trismus (HP:0000211)2.64546438
23Macrocytic anemia (HP:0001972)2.63057040
24Abnormality of the distal phalanges of the toes (HP:0010182)2.60880753
25Progressive external ophthalmoplegia (HP:0000590)2.57215809
26Abnormality of oral frenula (HP:0000190)2.56670888
27Fatigue (HP:0012378)2.56295961
28Reduced subcutaneous adipose tissue (HP:0003758)2.56283485
29Ankyloglossia (HP:0010296)2.56085339
30Rough bone trabeculation (HP:0100670)2.56012160
31Abnormal trabecular bone morphology (HP:0100671)2.55201670
32Sparse lateral eyebrow (HP:0005338)2.54257490
33Achilles tendon contracture (HP:0001771)2.51940657
34Progressive muscle weakness (HP:0003323)2.51334771
35Pheochromocytoma (HP:0002666)2.47621505
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47308315
37Reduced antithrombin III activity (HP:0001976)2.45848963
38Abnormality of the intrinsic pathway (HP:0010989)2.44597235
39Overlapping toe (HP:0001845)2.41337768
40Posterior subcapsular cataract (HP:0007787)2.34555173
41Ependymoma (HP:0002888)2.29882753
42Pallor (HP:0000980)2.29525960
43Abnormality of the Achilles tendon (HP:0005109)2.26756291
44Deep philtrum (HP:0002002)2.26715084
45Hand muscle atrophy (HP:0009130)2.24506832
46Osteolytic defects of the hand bones (HP:0009699)2.21307505
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.21307505
48Abnormal cartilage morphology (HP:0002763)2.21137246
49Astrocytoma (HP:0009592)2.19811502
50Abnormality of the astrocytes (HP:0100707)2.19811502
51Neuroendocrine neoplasm (HP:0100634)2.17076364
52Birth length less than 3rd percentile (HP:0003561)2.16060172
53Distal lower limb muscle weakness (HP:0009053)2.15486081
54Short nail (HP:0001799)2.14741498
55Chromsome breakage (HP:0040012)2.13955762
56Subcapsular cataract (HP:0000523)2.12996682
57Distal upper limb amyotrophy (HP:0007149)2.12815510
58Upper limb amyotrophy (HP:0009129)2.12815510
59Cutaneous melanoma (HP:0012056)2.07595728
60Secondary amenorrhea (HP:0000869)2.07174465
61Type I transferrin isoform profile (HP:0003642)2.05228483
62Elbow flexion contracture (HP:0002987)2.04106532
63Increased connective tissue (HP:0009025)2.03645380
64Abnormality of reticulocytes (HP:0004312)2.02795485
65Abnormal gallbladder physiology (HP:0012438)2.01641343
66Cholecystitis (HP:0001082)2.01641343
67Hypergonadotropic hypogonadism (HP:0000815)2.00666945
68Hypopigmentation of the fundus (HP:0007894)2.00241270
69Abnormal autonomic nervous system physiology (HP:0012332)1.99286511
70Abnormality of the preputium (HP:0100587)1.97630180
71Tinnitus (HP:0000360)1.96596730
72Premature rupture of membranes (HP:0001788)1.95888447
73Decreased subcutaneous fat (HP:0001002)1.95406367
74Breech presentation (HP:0001623)1.94803118
75Hypoproteinemia (HP:0003075)1.94316222
76Down-sloping shoulders (HP:0200021)1.93650596
77Flat occiput (HP:0005469)1.92079577
78Spinal cord compression (HP:0002176)1.91719673
79Protrusio acetabuli (HP:0003179)1.90416809
80Sparse eyelashes (HP:0000653)1.88631259
81Abnormality of the umbilical cord (HP:0010881)1.86159687
82Glioma (HP:0009733)1.85907690
83Delayed cranial suture closure (HP:0000270)1.84383714
84Tetraparesis (HP:0002273)1.83511420
85Neoplasm of head and neck (HP:0012288)1.82818483
86Esophageal neoplasm (HP:0100751)1.82818483
87Distal lower limb amyotrophy (HP:0008944)1.82524635
88Cafe-au-lait spot (HP:0000957)1.82522459
89CNS hypomyelination (HP:0003429)1.79941606
90Abnormality of subcutaneous fat tissue (HP:0001001)1.76948093
91Glucose intolerance (HP:0000833)1.76926603
92Peripheral hypomyelination (HP:0007182)1.76264181
93Abnormal delivery (HP:0001787)1.76102118
94Testicular atrophy (HP:0000029)1.74695042
95Self-mutilation (HP:0000742)1.72939454
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72241150
97Hypobetalipoproteinemia (HP:0003563)1.71106202
98Polar cataract (HP:0010696)1.68719542
99Squamous cell carcinoma (HP:0002860)1.67121386
100Abnormal glycosylation (HP:0012345)1.65837594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.71620894
2NME24.01171278
3EPHA23.06560766
4BUB12.84794967
5RPS6KB22.80515269
6NEK12.80153917
7MST1R2.69260895
8PAK42.32345800
9MET2.27401163
10EIF2AK32.27333924
11LMTK22.20035969
12SCYL22.11775999
13PAK61.88726425
14ILK1.70666297
15ARAF1.69563152
16NEK21.66404210
17PIK3CG1.63258086
18EIF2AK11.62754604
19BRAF1.60465725
20FLT31.59556921
21EEF2K1.59553011
22PBK1.59476234
23PRPF4B1.54443227
24TAOK21.54428172
25BRSK11.49341059
26WEE11.48649790
27IRAK21.47602797
28PAK21.43972501
29KSR21.40725923
30ERBB41.39982050
31CDK121.38266181
32BRSK21.37072607
33MOS1.32149782
34TSSK61.30814176
35TTK1.30051069
36TRIB31.29729806
37IRAK41.22042575
38SRPK11.18921722
39BMPR21.18419163
40TESK21.07791211
41LATS21.07693524
42CDC71.06943151
43PLK41.04055160
44CDK80.99741214
45CHEK20.99405301
46TTN0.99310109
47ERN10.96223947
48MAP3K80.93966079
49MAPKAPK30.89184529
50ICK0.87035547
51CCNB10.86894522
52CLK10.84201743
53NTRK10.84010366
54LRRK20.81763181
55STK160.81304050
56PAK10.81244415
57RAF10.80071963
58MAP3K130.79207451
59AURKA0.78191074
60CDK70.78183299
61PTK20.76982091
62PRKD30.76747388
63DYRK30.71491999
64CHEK10.71239615
65AURKB0.71121907
66PIM20.70396621
67PRKD20.69464361
68PLK10.69404191
69PRKCI0.69151676
70MAP3K90.66900063
71STK240.64830500
72IRAK10.62902719
73CDK60.56517477
74MAP3K120.55734719
75ERBB30.55313639
76ABL20.53932440
77AKT20.53897837
78PDGFRA0.51746978
79BRD40.51313492
80PKN20.51077015
81MTOR0.50458966
82PNCK0.49340876
83MARK30.45056462
84SIK20.44259650
85MARK20.42627855
86STK100.42285287
87CDK40.41719411
88MST40.41256781
89BMX0.39449475
90RPS6KA40.39385677
91AKT30.39239698
92WNK40.38797012
93TBK10.38016736
94MAP3K140.37432653
95PHKG20.36717996
96PHKG10.36717996
97NME10.36557859
98TESK10.36434587
99CDK10.36381826
100MAP3K20.35671672

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.99277829
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30218058
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.24117934
4DNA replication_Homo sapiens_hsa030302.97100915
5RNA polymerase_Homo sapiens_hsa030202.76317169
6RNA transport_Homo sapiens_hsa030132.41187770
7Nucleotide excision repair_Homo sapiens_hsa034202.39264446
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.37015630
9Pyrimidine metabolism_Homo sapiens_hsa002402.36472745
10Proteasome_Homo sapiens_hsa030502.31978421
11Mismatch repair_Homo sapiens_hsa034302.27313495
12Sulfur relay system_Homo sapiens_hsa041222.07624436
13Spliceosome_Homo sapiens_hsa030402.06517704
14Cell cycle_Homo sapiens_hsa041102.06030423
15N-Glycan biosynthesis_Homo sapiens_hsa005102.00306387
16Base excision repair_Homo sapiens_hsa034101.94836572
17One carbon pool by folate_Homo sapiens_hsa006701.83064773
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.64735210
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61298277
20Selenocompound metabolism_Homo sapiens_hsa004501.53729994
21Biosynthesis of amino acids_Homo sapiens_hsa012301.53142555
22mRNA surveillance pathway_Homo sapiens_hsa030151.47561386
23Basal transcription factors_Homo sapiens_hsa030221.39703835
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.35917311
25Homologous recombination_Homo sapiens_hsa034401.33921403
26Pentose phosphate pathway_Homo sapiens_hsa000301.33424856
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27252924
28Purine metabolism_Homo sapiens_hsa002301.26608026
29Folate biosynthesis_Homo sapiens_hsa007901.25833754
30Fanconi anemia pathway_Homo sapiens_hsa034601.21782068
31p53 signaling pathway_Homo sapiens_hsa041151.14748892
32Chronic myeloid leukemia_Homo sapiens_hsa052201.14376062
33Protein export_Homo sapiens_hsa030601.13032944
34Carbon metabolism_Homo sapiens_hsa012001.10930761
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10560812
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.10438741
37Prion diseases_Homo sapiens_hsa050201.09578279
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07971360
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06709867
40Pancreatic cancer_Homo sapiens_hsa052121.06101496
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02973565
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01766485
43Non-small cell lung cancer_Homo sapiens_hsa052230.98403689
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.91077139
45Fructose and mannose metabolism_Homo sapiens_hsa000510.88956146
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88641237
47Non-homologous end-joining_Homo sapiens_hsa034500.86190300
48Sulfur metabolism_Homo sapiens_hsa009200.85559918
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83124793
50Huntingtons disease_Homo sapiens_hsa050160.82363918
51mTOR signaling pathway_Homo sapiens_hsa041500.81949776
52Acute myeloid leukemia_Homo sapiens_hsa052210.81273635
53RNA degradation_Homo sapiens_hsa030180.77892340
54Renal cell carcinoma_Homo sapiens_hsa052110.77472827
55Epstein-Barr virus infection_Homo sapiens_hsa051690.76773503
56Galactose metabolism_Homo sapiens_hsa000520.75961659
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74695835
58Viral carcinogenesis_Homo sapiens_hsa052030.74005438
59ErbB signaling pathway_Homo sapiens_hsa040120.72447473
60Bladder cancer_Homo sapiens_hsa052190.71759392
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68883779
62Small cell lung cancer_Homo sapiens_hsa052220.67380580
63Apoptosis_Homo sapiens_hsa042100.67168703
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65169137
65MicroRNAs in cancer_Homo sapiens_hsa052060.65102054
66Glutathione metabolism_Homo sapiens_hsa004800.64612289
67Pyruvate metabolism_Homo sapiens_hsa006200.60058556
68Insulin signaling pathway_Homo sapiens_hsa049100.59023523
69Glioma_Homo sapiens_hsa052140.55443555
70HIF-1 signaling pathway_Homo sapiens_hsa040660.55260355
71Oocyte meiosis_Homo sapiens_hsa041140.54941941
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53487565
73Arginine biosynthesis_Homo sapiens_hsa002200.53042511
74Prostate cancer_Homo sapiens_hsa052150.50683994
75Thyroid cancer_Homo sapiens_hsa052160.49171183
76Fatty acid elongation_Homo sapiens_hsa000620.48915751
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47354281
78Parkinsons disease_Homo sapiens_hsa050120.45873486
79Vitamin B6 metabolism_Homo sapiens_hsa007500.44580283
80Shigellosis_Homo sapiens_hsa051310.43382139
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43073874
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42699787
83Colorectal cancer_Homo sapiens_hsa052100.41778711
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41719382
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41226429
86VEGF signaling pathway_Homo sapiens_hsa043700.40842279
87Hepatitis B_Homo sapiens_hsa051610.40656029
88Legionellosis_Homo sapiens_hsa051340.39828185
89HTLV-I infection_Homo sapiens_hsa051660.37949166
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37241095
91Metabolic pathways_Homo sapiens_hsa011000.37148851
92Tyrosine metabolism_Homo sapiens_hsa003500.34414483
93Inositol phosphate metabolism_Homo sapiens_hsa005620.32005421
94Endometrial cancer_Homo sapiens_hsa052130.30613479
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30015459
96Melanoma_Homo sapiens_hsa052180.28958716
97Alzheimers disease_Homo sapiens_hsa050100.28788428
98FoxO signaling pathway_Homo sapiens_hsa040680.27239256
99Proteoglycans in cancer_Homo sapiens_hsa052050.26174709
100Vibrio cholerae infection_Homo sapiens_hsa051100.25679425

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