CSTL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located at the telomeric end of the cystatin locus and encodes a type 2 cystatin-like protein. The specific function of this protein has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.88832007
2spermatid development (GO:0007286)9.86944204
3multicellular organism reproduction (GO:0032504)9.70933448
4epithelial cilium movement (GO:0003351)9.48046296
5plasma membrane fusion (GO:0045026)9.13303097
6axonemal dynein complex assembly (GO:0070286)8.95825521
7motile cilium assembly (GO:0044458)8.94392782
8reproduction (GO:0000003)8.65728384
9regulation of cilium movement (GO:0003352)8.49954757
10negative regulation of inclusion body assembly (GO:0090084)7.90228120
11cilium movement (GO:0003341)7.48174466
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.15535129
13sperm capacitation (GO:0048240)7.10745807
14cilium or flagellum-dependent cell motility (GO:0001539)7.02170598
15microtubule depolymerization (GO:0007019)6.93462172
16spermatogenesis (GO:0007283)6.87452272
17organic cation transport (GO:0015695)6.86377949
18male gamete generation (GO:0048232)6.84742243
19single fertilization (GO:0007338)6.77840916
20synaptonemal complex organization (GO:0070193)6.55339636
21regulation of inclusion body assembly (GO:0090083)6.48204828
22synaptonemal complex assembly (GO:0007130)6.46602981
23gamete generation (GO:0007276)6.30757090
24calcium ion-dependent exocytosis (GO:0017156)6.11261592
25piRNA metabolic process (GO:0034587)6.08227063
26male meiosis (GO:0007140)6.06528159
27chromosome condensation (GO:0030261)5.99830340
28fertilization (GO:0009566)5.79530876
29DNA packaging (GO:0006323)5.70093992
30response to pheromone (GO:0019236)5.61477267
31germ cell development (GO:0007281)5.36367805
32spermatid nucleus differentiation (GO:0007289)5.27573311
33glycerol ether metabolic process (GO:0006662)5.26527740
34behavioral response to nicotine (GO:0035095)5.19078030
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.18155855
36cell recognition (GO:0008037)5.13635781
37ventricular system development (GO:0021591)5.00857341
38regulation of microtubule-based movement (GO:0060632)4.99525964
39sexual reproduction (GO:0019953)4.97510660
40multicellular organismal reproductive process (GO:0048609)4.94610443
41ether metabolic process (GO:0018904)4.85888758
42microtubule severing (GO:0051013)4.77702319
43seminiferous tubule development (GO:0072520)4.70747251
44negative regulation of telomere maintenance (GO:0032205)4.65236267
45single strand break repair (GO:0000012)4.51074171
46male meiosis I (GO:0007141)4.45812044
47chromosome organization involved in meiosis (GO:0070192)4.29803021
48chaperone-mediated protein complex assembly (GO:0051131)4.21870287
49left/right pattern formation (GO:0060972)4.13559818
50multicellular organismal development (GO:0007275)4.07847363
51protein-cofactor linkage (GO:0018065)3.92870061
52cellular ketone body metabolic process (GO:0046950)3.89802112
53DNA methylation involved in gamete generation (GO:0043046)3.85573576
54DNA deamination (GO:0045006)3.79046270
55maturation of 5.8S rRNA (GO:0000460)3.72218533
56meiotic nuclear division (GO:0007126)3.68116490
57centriole replication (GO:0007099)3.67622780
58microtubule polymerization or depolymerization (GO:0031109)3.66798577
59establishment of protein localization to Golgi (GO:0072600)3.64232345
60sequestering of actin monomers (GO:0042989)3.62889306
61alditol metabolic process (GO:0019400)3.55433630
62axoneme assembly (GO:0035082)3.54392806
63protein K11-linked deubiquitination (GO:0035871)3.50408190
64protein polyglutamylation (GO:0018095)3.50006442
65ketone body metabolic process (GO:1902224)3.48728925
66meiosis I (GO:0007127)3.48115679
67protein targeting to Golgi (GO:0000042)3.46395918
68glycolytic process (GO:0006096)3.44272344
69tryptophan catabolic process (GO:0006569)3.41284340
70indole-containing compound catabolic process (GO:0042436)3.41284340
71indolalkylamine catabolic process (GO:0046218)3.41284340
72protein refolding (GO:0042026)3.35570147
73serotonin receptor signaling pathway (GO:0007210)3.27512842
74rRNA catabolic process (GO:0016075)3.24838699
75regulation of telomere maintenance (GO:0032204)3.24601672
76platelet dense granule organization (GO:0060155)3.22828794
77RNA destabilization (GO:0050779)3.21480492
78positive regulation of macrophage activation (GO:0043032)3.21107939
79glycerol metabolic process (GO:0006071)3.16976648
80glycerophospholipid catabolic process (GO:0046475)3.16174231
81indolalkylamine metabolic process (GO:0006586)3.16141515
82detection of light stimulus involved in visual perception (GO:0050908)3.13282938
83detection of light stimulus involved in sensory perception (GO:0050962)3.13282938
84genitalia morphogenesis (GO:0035112)3.12682648
85polyamine biosynthetic process (GO:0006596)3.08785692
86regulation of spindle checkpoint (GO:0090231)3.08665056
87L-fucose catabolic process (GO:0042355)3.07318595
88fucose catabolic process (GO:0019317)3.07318595
89L-fucose metabolic process (GO:0042354)3.07318595
90protein localization to Golgi apparatus (GO:0034067)3.04646492
91protein import into peroxisome matrix (GO:0016558)3.04133823
92retrograde transport, vesicle recycling within Golgi (GO:0000301)3.03577437
93protein complex biogenesis (GO:0070271)3.03046376
94nucleus organization (GO:0006997)3.02511247
95nucleoside diphosphate phosphorylation (GO:0006165)3.00599157
96polyol catabolic process (GO:0046174)3.00136227
97protein localization to cilium (GO:0061512)2.96863436
98negative regulation of mast cell activation (GO:0033004)2.94399768
99tryptophan metabolic process (GO:0006568)2.94103418
100ATP hydrolysis coupled proton transport (GO:0015991)2.93527038
101energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93527038
102regulation of glucokinase activity (GO:0033131)2.93382969
103regulation of hexokinase activity (GO:1903299)2.93382969
104sulfation (GO:0051923)2.90971079
105mitotic sister chromatid cohesion (GO:0007064)2.90875607
106nonmotile primary cilium assembly (GO:0035058)2.90287828
107pyrimidine nucleobase catabolic process (GO:0006208)2.89765104
108detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89550377
109RNA localization (GO:0006403)2.89009008
110meiotic cell cycle (GO:0051321)2.86105375
111carnitine transport (GO:0015879)2.85703769
112amino-acid betaine transport (GO:0015838)2.85703769
113nephron epithelium morphogenesis (GO:0072088)2.85482637
114nephron tubule morphogenesis (GO:0072078)2.85482637
115GTP biosynthetic process (GO:0006183)2.84819499
116water-soluble vitamin biosynthetic process (GO:0042364)2.83470543
117gamma-aminobutyric acid transport (GO:0015812)2.82578052
118mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82359483
119mitochondrial respiratory chain complex I assembly (GO:0032981)2.82359483
120NADH dehydrogenase complex assembly (GO:0010257)2.82359483
121DNA double-strand break processing (GO:0000729)2.81949254
122chromatin silencing (GO:0006342)2.79038155
123regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72450802
124mitochondrial respiratory chain complex assembly (GO:0033108)2.71980696
125neuronal action potential (GO:0019228)2.71804341
126nucleobase catabolic process (GO:0046113)2.70855715
127behavioral response to ethanol (GO:0048149)2.70706248
128cilium morphogenesis (GO:0060271)2.69714388
129reflex (GO:0060004)2.68332904
130regulation of action potential (GO:0098900)2.65812219
131carnitine transmembrane transport (GO:1902603)2.65579975
132retinal cone cell development (GO:0046549)2.65229098
133respiratory chain complex IV assembly (GO:0008535)2.64067926
134mitochondrion degradation (GO:0000422)2.63325832
135cilium organization (GO:0044782)2.62523590
136regulation of cilium assembly (GO:1902017)2.62011039
137rRNA methylation (GO:0031167)2.61847226
138kynurenine metabolic process (GO:0070189)2.61737506
139centriole assembly (GO:0098534)2.60939549
140somite rostral/caudal axis specification (GO:0032525)2.60636266
141synaptic transmission, cholinergic (GO:0007271)2.57972548
142microtubule-based movement (GO:0007018)2.56623093
143rRNA modification (GO:0000154)2.56579041
144positive regulation of glycolytic process (GO:0045821)2.56154046
145negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55382059
146cilium assembly (GO:0042384)2.54972434
147membrane depolarization during action potential (GO:0086010)2.54767457
148amine catabolic process (GO:0009310)2.53918136
149cellular biogenic amine catabolic process (GO:0042402)2.53918136
150protein depolymerization (GO:0051261)2.53635160
151interferon-gamma secretion (GO:0072643)2.52977513
152cellular component assembly involved in morphogenesis (GO:0010927)2.52447353
153negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51809719
154calcium ion import (GO:0070509)2.49369897
155cytochrome complex assembly (GO:0017004)2.48442066
156lactate metabolic process (GO:0006089)2.48361875
157mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48251404
158UTP biosynthetic process (GO:0006228)2.47717226
159synapsis (GO:0007129)2.47318311
160meiotic cell cycle process (GO:1903046)2.43350525
161sperm motility (GO:0030317)14.3629937
162cell wall macromolecule catabolic process (GO:0016998)12.8957766
163cell wall macromolecule metabolic process (GO:0044036)12.8957766
164acrosome reaction (GO:0007340)12.5108052
165fusion of sperm to egg plasma membrane (GO:0007342)11.7957403
166acrosome assembly (GO:0001675)11.1903139
167sperm-egg recognition (GO:0035036)11.0668700
168binding of sperm to zona pellucida (GO:0007339)10.1715873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.20256776
2EZH2_22144423_ChIP-Seq_EOC_Human6.08827759
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.09910445
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05483582
5VDR_22108803_ChIP-Seq_LS180_Human2.81410456
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.69699440
7ZNF274_21170338_ChIP-Seq_K562_Hela2.43340872
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11752547
9IGF1R_20145208_ChIP-Seq_DFB_Human2.06235910
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00705486
11P300_19829295_ChIP-Seq_ESCs_Human1.96462646
12ER_23166858_ChIP-Seq_MCF-7_Human1.94436006
13GATA1_26923725_Chip-Seq_HPCs_Mouse1.90632469
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88189201
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87871636
16* REST_21632747_ChIP-Seq_MESCs_Mouse1.86149991
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.83543659
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.82382959
19MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.79244368
20KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78991635
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.76890047
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75289690
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74314820
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73212796
25EWS_26573619_Chip-Seq_HEK293_Human1.72633728
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70489962
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67040229
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65511646
29AR_25329375_ChIP-Seq_VCAP_Human1.64318184
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64271958
31TP53_22573176_ChIP-Seq_HFKS_Human1.55995741
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55713596
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54613441
34STAT1_17558387_ChIP-Seq_HELA_Human1.52106831
35KDM2B_26808549_Chip-Seq_REH_Human1.49747400
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46450391
37GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.46178969
38SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45091452
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.44928870
40TAF15_26573619_Chip-Seq_HEK293_Human1.44450522
41STAT3_23295773_ChIP-Seq_U87_Human1.43505725
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.42838634
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41671069
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.41671069
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.41451653
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.39962391
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39374770
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38488399
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.38335117
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36617231
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36372028
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36119402
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35520843
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35520843
55NANOG_19829295_ChIP-Seq_ESCs_Human1.35085663
56SOX2_19829295_ChIP-Seq_ESCs_Human1.35085663
57FUS_26573619_Chip-Seq_HEK293_Human1.34788699
58FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34699616
59MYC_18940864_ChIP-ChIP_HL60_Human1.33326675
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31914808
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31843440
62IRF1_19129219_ChIP-ChIP_H3396_Human1.31347228
63GATA3_21867929_ChIP-Seq_CD8_Mouse1.31049506
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30279835
65TCF4_23295773_ChIP-Seq_U87_Human1.30041495
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29720455
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29666322
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.29095107
69BCAT_22108803_ChIP-Seq_LS180_Human1.28989932
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28817426
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28464671
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27027797
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26090878
74RUNX2_22187159_ChIP-Seq_PCA_Human1.25604791
75CBP_20019798_ChIP-Seq_JUKART_Human1.25159775
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25159775
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24874731
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24853090
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.24541105
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23323029
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23216813
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23116530
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23108379
84P53_21459846_ChIP-Seq_SAOS-2_Human1.22929994
85MYC_19829295_ChIP-Seq_ESCs_Human1.22821949
86ERA_21632823_ChIP-Seq_H3396_Human1.21993144
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21799012
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.20038265
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.19732485
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19475343
91NCOR_22424771_ChIP-Seq_293T_Human1.18777797
92AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17699001
93ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15481490
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14996293
95AR_20517297_ChIP-Seq_VCAP_Human1.14529025
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.14358491
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13624712
98GF1_26923725_Chip-Seq_HPCs_Mouse1.13500363
99TCF4_22108803_ChIP-Seq_LS180_Human1.13456526
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13136629
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12738136
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12601548
103NANOG_20526341_ChIP-Seq_ESCs_Human1.12538007
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12493397
105DROSHA_22980978_ChIP-Seq_HELA_Human1.12286614
106HOXB7_26014856_ChIP-Seq_BT474_Human1.11403506
107MYC_27129775_Chip-Seq_CORNEA_Mouse1.10601922
108* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09606317
109CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09010706
110CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08023454
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.07196361
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.06469384
113TAF2_19829295_ChIP-Seq_ESCs_Human1.06208882
114RNF2_27304074_Chip-Seq_NSC_Mouse1.06077317
115AR_21572438_ChIP-Seq_LNCaP_Human1.05915275
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.05468228
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04838643
118EED_16625203_ChIP-ChIP_MESCs_Mouse1.03443742
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03277277
120GABP_17652178_ChIP-ChIP_JURKAT_Human1.02173734
121SPI1_26923725_Chip-Seq_HPCs_Mouse1.01369735
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01305103
123P53_22387025_ChIP-Seq_ESCs_Mouse1.01260331
124GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00386490
125SOX9_26525672_Chip-Seq_HEART_Mouse1.00276905
126FOXH1_21741376_ChIP-Seq_EPCs_Human1.00056035
127EST1_17652178_ChIP-ChIP_JURKAT_Human0.98703592
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98451170
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97652578
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96468050
131* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96282177
132IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95972583
133ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95793973
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.95722576
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95573628
136EZH2_27304074_Chip-Seq_ESCs_Mouse0.95377311
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95160099
138SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94500354
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.94430648
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94208612
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93869951
142SMAD4_21799915_ChIP-Seq_A2780_Human0.93802252
143EZH2_27294783_Chip-Seq_ESCs_Mouse0.93460933
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93405583
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93344754
146KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93284764
147CRX_20693478_ChIP-Seq_RETINA_Mouse0.92881079
148NFYB_21822215_ChIP-Seq_K562_Human0.92812786
149OCT4_18555785_Chip-Seq_ESCs_Mouse0.92742320
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.92655683
151TBL1_22424771_ChIP-Seq_293T_Human0.92618986
152PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91937062
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91801616
154GBX2_23144817_ChIP-Seq_PC3_Human0.91563163
155REST_18959480_ChIP-ChIP_MESCs_Mouse0.91355767
156SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.90987682
157TET1_21451524_ChIP-Seq_MESCs_Mouse0.90888681
158CTCF_27219007_Chip-Seq_Bcells_Human0.90656244
159ERG_20517297_ChIP-Seq_VCAP_Human0.90541756
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.90530027
161P300_18555785_Chip-Seq_ESCs_Mouse0.90260223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.61637151
2MP0001929_abnormal_gametogenesis5.05125079
3MP0008877_abnormal_DNA_methylation3.87440547
4MP0002161_abnormal_fertility/fecundity3.09928203
5MP0002210_abnormal_sex_determination2.79457641
6MP0005670_abnormal_white_adipose2.76847010
7MP0001145_abnormal_male_reproductive2.39047130
8MP0003195_calcinosis2.31266843
9MP0005645_abnormal_hypothalamus_physiol2.24749183
10MP0006276_abnormal_autonomic_nervous2.18398397
11MP0000653_abnormal_sex_gland2.07715676
12MP0004233_abnormal_muscle_weight2.00951401
13MP0005410_abnormal_fertilization15.6665531
14MP0002876_abnormal_thyroid_physiology1.96004022
15MP0002254_reproductive_system_inflammat1.93958440
16MP0000569_abnormal_digit_pigmentation1.87584735
17MP0006072_abnormal_retinal_apoptosis1.86380584
18MP0008875_abnormal_xenobiotic_pharmacok1.86128411
19MP0003646_muscle_fatigue1.85856932
20MP0004859_abnormal_synaptic_plasticity1.85753285
21MP0002736_abnormal_nociception_after1.83768600
22MP0003011_delayed_dark_adaptation1.77942522
23MP0001986_abnormal_taste_sensitivity1.76641375
24MP0003880_abnormal_central_pattern1.68649168
25MP0004270_analgesia1.68178471
26MP0008872_abnormal_physiological_respon1.61851709
27MP0006292_abnormal_olfactory_placode1.61591462
28MP0000372_irregular_coat_pigmentation1.57702058
29MP0003787_abnormal_imprinting1.56226585
30MP0005084_abnormal_gallbladder_morpholo1.53624491
31MP0001968_abnormal_touch/_nociception1.53252173
32MP0002653_abnormal_ependyma_morphology1.46291087
33MP0003122_maternal_imprinting1.45476410
34MP0004885_abnormal_endolymph1.44760105
35MP0003718_maternal_effect1.42950347
36MP0005379_endocrine/exocrine_gland_phen1.39779598
37MP0003121_genomic_imprinting1.39165193
38MP0002234_abnormal_pharynx_morphology1.38888031
39MP0001765_abnormal_ion_homeostasis1.38793145
40MP0009046_muscle_twitch1.37212156
41MP0002928_abnormal_bile_duct1.36429504
42MP0000631_abnormal_neuroendocrine_gland1.33801456
43MP0002138_abnormal_hepatobiliary_system1.33449514
44MP0008995_early_reproductive_senescence1.31171570
45MP0002163_abnormal_gland_morphology1.30216419
46MP0003283_abnormal_digestive_organ1.29293286
47MP0001485_abnormal_pinna_reflex1.28738399
48MP0003635_abnormal_synaptic_transmissio1.28265948
49MP0001919_abnormal_reproductive_system1.27274297
50MP0002938_white_spotting1.26872352
51MP0005310_abnormal_salivary_gland1.17281896
52MP0003136_yellow_coat_color1.15438825
53MP0002638_abnormal_pupillary_reflex1.14886282
54MP0009745_abnormal_behavioral_response1.13529784
55MP0002063_abnormal_learning/memory/cond1.11952431
56MP0010386_abnormal_urinary_bladder1.08260632
57MP0000427_abnormal_hair_cycle1.04369723
58MP0002160_abnormal_reproductive_system1.04178515
59MP0000230_abnormal_systemic_arterial1.02365340
60MP0005386_behavior/neurological_phenoty1.01873059
61MP0004924_abnormal_behavior1.01873059
62MP0005423_abnormal_somatic_nervous1.01565058
63MP0001984_abnormal_olfaction1.00836630
64MP0002064_seizures0.95597472
65MP0002282_abnormal_trachea_morphology0.94050604
66MP0002572_abnormal_emotion/affect_behav0.93501253
67MP0002277_abnormal_respiratory_mucosa0.90844502
68MP0005195_abnormal_posterior_eye0.89699435
69MP0002693_abnormal_pancreas_physiology0.88245144
70MP0000026_abnormal_inner_ear0.86957204
71MP0005174_abnormal_tail_pigmentation0.85678735
72MP0003252_abnormal_bile_duct0.84782132
73MP0005623_abnormal_meninges_morphology0.83584409
74MP0000516_abnormal_urinary_system0.83581693
75MP0005367_renal/urinary_system_phenotyp0.83581693
76MP0005075_abnormal_melanosome_morpholog0.82722375
77MP0002752_abnormal_somatic_nervous0.79297885
78MP0002272_abnormal_nervous_system0.79060050
79MP0005167_abnormal_blood-brain_barrier0.78895003
80MP0001502_abnormal_circadian_rhythm0.78795826
81MP0001440_abnormal_grooming_behavior0.77800845
82MP0003329_amyloid_beta_deposits0.75959464
83MP0004811_abnormal_neuron_physiology0.72202113
84MP0005377_hearing/vestibular/ear_phenot0.71644156
85MP0003878_abnormal_ear_physiology0.71644156
86MP0000751_myopathy0.68786860
87MP0004036_abnormal_muscle_relaxation0.68484299
88MP0003879_abnormal_hair_cell0.68255509
89MP0004145_abnormal_muscle_electrophysio0.67027377
90MP0008569_lethality_at_weaning0.65642993
91MP0002067_abnormal_sensory_capabilities0.63503302
92MP0003633_abnormal_nervous_system0.63132539
93MP0001486_abnormal_startle_reflex0.61276939
94MP0003115_abnormal_respiratory_system0.59485698
95MP0003631_nervous_system_phenotype0.57146518
96MP0008961_abnormal_basal_metabolism0.57063715
97MP0001501_abnormal_sleep_pattern0.56422962
98MP0002734_abnormal_mechanical_nocicepti0.56112937
99MP0002269_muscular_atrophy0.54478755
100MP0002735_abnormal_chemical_nociception0.53409291
101MP0005636_abnormal_mineral_homeostasis0.52784365
102MP0002733_abnormal_thermal_nociception0.51957800
103MP0001905_abnormal_dopamine_level0.50970936
104MP0005646_abnormal_pituitary_gland0.49320427
105MP0005647_abnormal_sex_gland0.47707539
106MP0005551_abnormal_eye_electrophysiolog0.46884989
107MP0001324_abnormal_eye_pigmentation0.46041362
108MP0006036_abnormal_mitochondrial_physio0.44065038
109MP0002152_abnormal_brain_morphology0.44057517
110MP0005389_reproductive_system_phenotype0.42156344
111MP0005171_absent_coat_pigmentation0.41441962
112MP0002837_dystrophic_cardiac_calcinosis0.40715012
113MP0004742_abnormal_vestibular_system0.40609786
114MP0002557_abnormal_social/conspecific_i0.40607388
115MP0002882_abnormal_neuron_morphology0.40373212
116MP0002066_abnormal_motor_capabilities/c0.40053870
117MP0003699_abnormal_female_reproductive0.39763225
118MP0002102_abnormal_ear_morphology0.38329670
119MP0006035_abnormal_mitochondrial_morpho0.37102960
120MP0001764_abnormal_homeostasis0.36527488
121MP0000015_abnormal_ear_pigmentation0.35147890
122MP0000534_abnormal_ureter_morphology0.34924756
123MP0003632_abnormal_nervous_system0.34908992
124MP0002909_abnormal_adrenal_gland0.34699163
125MP0005253_abnormal_eye_physiology0.34638945
126MP0001529_abnormal_vocalization0.33802782
127MP0009115_abnormal_fat_cell0.33279760
128MP0002822_catalepsy0.33183876
129MP0001970_abnormal_pain_threshold0.32221121
130MP0003861_abnormal_nervous_system0.31730627
131MP0005666_abnormal_adipose_tissue0.31648655
132MP0002106_abnormal_muscle_physiology0.31582432
133MP0000604_amyloidosis0.30562193
134MP0000955_abnormal_spinal_cord0.30260247
135MP0000358_abnormal_cell_content/0.29964584
136MP0000778_abnormal_nervous_system0.29411271
137MP0005535_abnormal_body_temperature0.29288879
138MP0002873_normal_phenotype0.29150579
139MP0004043_abnormal_pH_regulation0.29069354
140MP0002169_no_abnormal_phenotype0.28992765
141MP0001963_abnormal_hearing_physiology0.28935986
142MP0002229_neurodegeneration0.28428234
143MP0008058_abnormal_DNA_repair0.27618579
144MP0002069_abnormal_eating/drinking_beha0.26615378
145MP0004133_heterotaxia0.25584673
146MP0004142_abnormal_muscle_tone0.25481712
147MP0002971_abnormal_brown_adipose0.25213491
148MP0001727_abnormal_embryo_implantation0.24664414

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.18423520
2Abnormal respiratory motile cilium morphology (HP:0005938)9.18423520
3Abnormal respiratory motile cilium physiology (HP:0012261)9.06846359
4Infertility (HP:0000789)7.21019286
5Abnormal ciliary motility (HP:0012262)7.13930017
6Chronic bronchitis (HP:0004469)6.96007488
7Rhinitis (HP:0012384)6.92451845
8Nasal polyposis (HP:0100582)5.76689517
9Male infertility (HP:0003251)4.89479045
10Abnormality of the nasal mucosa (HP:0000433)4.68086904
11Pancreatic cysts (HP:0001737)4.19281208
12Bronchitis (HP:0012387)4.11400151
13Bronchiectasis (HP:0002110)3.95114014
14Pancreatic fibrosis (HP:0100732)3.92342083
15Nephronophthisis (HP:0000090)3.90159173
16True hermaphroditism (HP:0010459)3.73321381
17Attenuation of retinal blood vessels (HP:0007843)3.64491559
18Chronic hepatic failure (HP:0100626)3.62840959
19Congenital stationary night blindness (HP:0007642)3.57993466
20Abnormal spermatogenesis (HP:0008669)3.44637676
21Abnormal rod and cone electroretinograms (HP:0008323)3.07074763
22Abnormal gallbladder physiology (HP:0012438)2.97788961
23Cholecystitis (HP:0001082)2.97788961
24Bony spicule pigmentary retinopathy (HP:0007737)2.96076329
25Recurrent otitis media (HP:0000403)2.92526126
26Abolished electroretinogram (ERG) (HP:0000550)2.88682222
27Abnormality of the renal medulla (HP:0100957)2.87224337
28Recurrent sinusitis (HP:0011108)2.86493675
29Tubulointerstitial nephritis (HP:0001970)2.72337237
30Cystic liver disease (HP:0006706)2.61937319
31Polyuria (HP:0000103)2.57596211
32Tubular atrophy (HP:0000092)2.56692876
33Medial flaring of the eyebrow (HP:0010747)2.52192014
34Pendular nystagmus (HP:0012043)2.52017658
35Impulsivity (HP:0100710)2.49808274
36Cerebellar dysplasia (HP:0007033)2.41743267
37Abnormality of midbrain morphology (HP:0002418)2.32416695
38Molar tooth sign on MRI (HP:0002419)2.32416695
39Mitochondrial inheritance (HP:0001427)2.30098532
40Increased CSF lactate (HP:0002490)2.27111591
41Lissencephaly (HP:0001339)2.26471206
42Tubulointerstitial abnormality (HP:0001969)2.26331074
43Congenital sensorineural hearing impairment (HP:0008527)2.25536304
44Choroideremia (HP:0001139)2.23754001
45Congenital malformation of the right heart (HP:0011723)2.22682679
46Double outlet right ventricle (HP:0001719)2.22682679
47Recurrent bronchitis (HP:0002837)2.21661927
48Abnormality of macular pigmentation (HP:0008002)2.20819900
49Inability to walk (HP:0002540)2.20631360
50Focal motor seizures (HP:0011153)2.20553925
51Exercise-induced myalgia (HP:0003738)2.18957404
52Hypothermia (HP:0002045)2.18713393
53Sclerocornea (HP:0000647)2.12721812
54Acute necrotizing encephalopathy (HP:0006965)2.12122855
55Limb dystonia (HP:0002451)2.12013678
56Optic nerve hypoplasia (HP:0000609)2.10388251
57Acute encephalopathy (HP:0006846)2.09628281
58Hepatocellular necrosis (HP:0001404)2.08351860
59Decreased central vision (HP:0007663)2.05756915
60Dyschromatopsia (HP:0007641)2.05651077
61Male pseudohermaphroditism (HP:0000037)2.04887558
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01967799
63Anencephaly (HP:0002323)2.01890959
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01710932
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.00554774
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00395948
67Abnormality of alanine metabolism (HP:0010916)2.00395948
68Hyperalaninemia (HP:0003348)2.00395948
69Dynein arm defect of respiratory motile cilia (HP:0012255)13.3471291
70Absent/shortened dynein arms (HP:0200106)13.3471291
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2962156
72Genital tract atresia (HP:0001827)1.99447614
73Abnormality of the labia minora (HP:0012880)1.98173345
74Spastic tetraparesis (HP:0001285)1.98123016
75Hepatic necrosis (HP:0002605)1.97740530
76Decreased circulating renin level (HP:0003351)1.97440992
77Large for gestational age (HP:0001520)1.96559695
78Abnormality of urine glucose concentration (HP:0011016)1.95976780
79Glycosuria (HP:0003076)1.95976780
80Occipital encephalocele (HP:0002085)1.94538988
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92819160
82Gaze-evoked nystagmus (HP:0000640)1.91067553
83Renal Fanconi syndrome (HP:0001994)1.89566054
84Gonadotropin excess (HP:0000837)1.89541899
85Keratoconus (HP:0000563)1.89338356
86Increased corneal curvature (HP:0100692)1.89338356
87Amelogenesis imperfecta (HP:0000705)1.89296466
88Azoospermia (HP:0000027)1.89127116
89Progressive macrocephaly (HP:0004481)1.88612165
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.88269208
91Methylmalonic acidemia (HP:0002912)1.87806829
92Optic disc pallor (HP:0000543)1.86968464
93Intestinal atresia (HP:0011100)1.84385986
94Hypomagnesemia (HP:0002917)1.83526200
95Sensory axonal neuropathy (HP:0003390)1.82751859
96Facial shape deformation (HP:0011334)1.82658823
97Potter facies (HP:0002009)1.82658823
98Ketoacidosis (HP:0001993)1.81875222
99Hyperglycinuria (HP:0003108)1.81783576
100Asplenia (HP:0001746)1.81454035
101Renal cortical cysts (HP:0000803)1.81222056
102Brushfield spots (HP:0001088)1.81196757
103Hyperglycinemia (HP:0002154)1.80739070
104Neurofibrillary tangles (HP:0002185)1.80267238
105Chorioretinal atrophy (HP:0000533)1.79975177
106Congenital, generalized hypertrichosis (HP:0004540)1.79406239
107Hemorrhage of the eye (HP:0011885)1.78828793
108Pachygyria (HP:0001302)1.77833377
109Tubulointerstitial fibrosis (HP:0005576)1.76487200
110Bundle branch block (HP:0011710)1.71376504
111Aplasia/Hypoplasia of the lens (HP:0008063)1.70732502
112Progressive cerebellar ataxia (HP:0002073)1.69738254
113Myoglobinuria (HP:0002913)1.64809749
114Cerebral inclusion bodies (HP:0100314)1.64807059
115Abnormal drinking behavior (HP:0030082)1.62899785
116Polydipsia (HP:0001959)1.62899785
117Stage 5 chronic kidney disease (HP:0003774)1.61301085
118Hyperventilation (HP:0002883)1.56813630
119Abnormal biliary tract physiology (HP:0012439)1.53201713
120Bile duct proliferation (HP:0001408)1.53201713
121Exercise-induced muscle cramps (HP:0003710)1.52993500
122Heterotopia (HP:0002282)1.50838782
123Abnormality of renal excretion (HP:0011036)1.50132132
124Gait imbalance (HP:0002141)1.49285731
125Abnormality of the renal cortex (HP:0011035)1.49276019
126Postaxial foot polydactyly (HP:0001830)1.48956882
127Asymmetric septal hypertrophy (HP:0001670)1.48432977
128Bell-shaped thorax (HP:0001591)1.47627874
129Congenital primary aphakia (HP:0007707)1.45885960
130Decreased muscle mass (HP:0003199)1.42924372
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.41016475
132Congenital hepatic fibrosis (HP:0002612)1.40687796
133Oculomotor apraxia (HP:0000657)1.39727535
134Neoplasm of the heart (HP:0100544)1.39528445
135Hemiparesis (HP:0001269)1.37985191
136Postaxial hand polydactyly (HP:0001162)1.37549090
137Retinal dysplasia (HP:0007973)1.37306901
138Polyphagia (HP:0002591)1.37092637
139Global brain atrophy (HP:0002283)1.34986391
140Abnormality of the lower motor neuron (HP:0002366)1.34855555
141Easy fatigability (HP:0003388)1.33781199
142Fatigable weakness (HP:0003473)1.31829923
143Abnormality of the neuromuscular junction (HP:0003398)1.31829923
144Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.30643196
145Rhabdomyolysis (HP:0003201)1.30192063
146Constricted visual fields (HP:0001133)1.29517021
147Abnormal urine output (HP:0012590)1.28895160
148Postural instability (HP:0002172)1.28115476
149Dysmetric saccades (HP:0000641)1.26652887
150Epileptic encephalopathy (HP:0200134)1.24357269
151Short ribs (HP:0000773)1.24072163
152Hypercholesterolemia (HP:0003124)1.23274349
153Impaired vibration sensation in the lower limbs (HP:0002166)1.22616187
154Abnormality of saccadic eye movements (HP:0000570)1.22535442
155Nephrogenic diabetes insipidus (HP:0009806)1.21357918
156Aplasia/Hypoplasia affecting the retina (HP:0008061)1.20612528
157Severe visual impairment (HP:0001141)1.20386828
158Absent eyebrow (HP:0002223)1.19648690
159Abnormality of the dental root (HP:0006486)1.17994995
160Taurodontia (HP:0000679)1.17994995
161Abnormality of permanent molar morphology (HP:0011071)1.17994995
162Vaginal atresia (HP:0000148)1.16813736
163Broad distal phalanx of finger (HP:0009836)1.16259400
164Type II lissencephaly (HP:0007260)1.16020704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.68610132
2PDK47.68610132
3TESK16.14779285
4FRK4.95399607
5PDK24.94301988
6PRKD34.89076968
7ICK4.34866769
8MAP4K23.63140257
9WNK32.99937517
10ADRBK22.82996960
11TLK12.54700952
12PLK42.52886737
13INSRR2.40001967
14BMPR1B2.35557780
15PTK2B2.31881146
16STK382.31615658
17ZAK2.30122664
18NUAK12.26301358
19RIPK42.15793078
20GRK12.07831550
21WNK42.07072009
22STK392.05144734
23MAPK131.89947373
24BCKDK1.60076549
25DYRK1B1.55879897
26TAOK31.48405554
27PDK11.44271516
28DYRK21.42985612
29ACVR1B1.41664009
30TXK1.40832817
31PNCK1.34160642
32TAF11.28053723
33VRK21.23941488
34MAPKAPK31.22275776
35TRIM281.16083046
36EPHA41.10092060
37NEK21.08303446
38PDPK11.08130211
39MAP3K41.08112601
40NTRK31.06548734
41PHKG11.06335520
42PHKG21.06335520
43PAK31.02941888
44CAMKK21.00561664
45MAP2K71.00277862
46TIE10.93519752
47NTRK20.86335257
48CSNK1G20.85473983
49CSNK1G10.85260417
50TNIK0.83997640
51PRKCE0.83004806
52ADRBK10.81852397
53PINK10.81605623
54VRK10.81470359
55CAMK1G0.76283507
56MUSK0.75606449
57CSNK1G30.74231620
58STK38L0.74003462
59PRKCG0.73587720
60WNK10.72951048
61FGFR20.72668062
62CCNB10.71731819
63CAMK10.71141009
64TYRO30.70063472
65KIT0.69941311
66PKN10.63049069
67MARK20.61494639
68DYRK30.61094462
69BRAF0.60985415
70CASK0.60427458
71FLT30.60209669
72AKT30.58269239
73CDK190.57668028
74MAP2K60.56602054
75CAMK1D0.55989826
76SIK20.54358981
77DAPK10.52676879
78CHEK20.52587088
79FER0.51589782
80MAP3K90.49938832
81IKBKB0.49857057
82RPS6KA50.48269927
83MAPK150.47718578
84MKNK10.46838212
85DYRK1A0.45467472
86MAP3K110.44377754
87PAK10.43783589
88IRAK10.42317108
89ERBB30.42069825
90CSNK1A10.42037559
91DAPK20.41848633
92PRKAA20.41663069
93TTK0.41443236
94MINK10.40813787
95NEK60.40278508
96MAP2K40.40246079
97CDK150.39660822
98ITK0.39618270
99CSNK1A1L0.38595526
100CDK180.38438378
101TGFBR10.38284827
102CAMK2A0.37986458
103TNK20.37976930
104PIK3CG0.37502458
105PIK3CA0.37143133
106GRK70.37074831
107CDK11A0.35873156
108MAP2K20.35011296
109CAMKK10.34178739
110TEC0.32530451
111PRKCI0.32522281
112BMPR20.31878819
113PLK30.30926720
114OXSR10.29253886
115CDK140.29122011
116PRKCQ0.29045322
117ARAF0.25149108
118PAK60.24919925
119PRKCZ0.22141978
120CDK50.22136851
121TESK20.22099655
122PLK20.21329708
123CHEK10.21069535
124NME10.20576230
125MAP3K130.20325558
126CAMK2B0.19793328
127MKNK20.19758033
128LMTK20.19384018
129CDK30.18808122
130MAP3K100.18740815
131PASK0.18124613
132IRAK20.18038999
133PRKG10.16543949
134STK30.16170997
135EEF2K0.15244066
136MARK10.14976899
137RAF10.14263105
138NTRK10.14059806
139PRKAA10.12644278
140GRK50.12072367
141PAK40.11416303
142DMPK0.11348705
143MAPKAPK50.10571733
144RPS6KB10.10130973
145STK160.09313252
146UHMK10.08901757
147STK110.08653990
148KSR20.08057025
149PRKCA0.07425558
150EIF2AK30.06639662
151GSK3B0.06472346
152PRKACA0.06329094
153PRKCB0.06021318
154YES10.05604790
155MAP3K60.05260377
156PAK20.05133554
157BRSK10.04750063
158RPS6KA30.03106202
159CAMK2G0.02548234
160ATM0.01631201

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.17262912
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.05001428
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.13466220
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.08531490
5Pyruvate metabolism_Homo sapiens_hsa006202.94691160
6Phototransduction_Homo sapiens_hsa047442.71796204
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.65168640
8Vitamin B6 metabolism_Homo sapiens_hsa007502.62625020
9Butanoate metabolism_Homo sapiens_hsa006502.59612324
10Linoleic acid metabolism_Homo sapiens_hsa005912.59494992
11Collecting duct acid secretion_Homo sapiens_hsa049662.51301120
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.41666761
13Amphetamine addiction_Homo sapiens_hsa050312.40559250
14Glucagon signaling pathway_Homo sapiens_hsa049222.39404161
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.12454523
16Parkinsons disease_Homo sapiens_hsa050122.09924435
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08700121
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06631349
19Nitrogen metabolism_Homo sapiens_hsa009102.05260039
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01300532
21Synaptic vesicle cycle_Homo sapiens_hsa047211.98348407
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94008689
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92606632
24Long-term potentiation_Homo sapiens_hsa047201.89091835
25Propanoate metabolism_Homo sapiens_hsa006401.86986215
26Protein export_Homo sapiens_hsa030601.77782008
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75216494
28Nicotine addiction_Homo sapiens_hsa050331.70116125
29Tryptophan metabolism_Homo sapiens_hsa003801.66626936
30Fanconi anemia pathway_Homo sapiens_hsa034601.65879776
31Renin secretion_Homo sapiens_hsa049241.59700204
32Cardiac muscle contraction_Homo sapiens_hsa042601.55678623
33RNA polymerase_Homo sapiens_hsa030201.52141236
34Peroxisome_Homo sapiens_hsa041461.52061337
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49152022
36Mineral absorption_Homo sapiens_hsa049781.48861702
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48539172
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.47784066
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45874367
40Basal transcription factors_Homo sapiens_hsa030221.45694700
41Glycerolipid metabolism_Homo sapiens_hsa005611.45178016
42Caffeine metabolism_Homo sapiens_hsa002321.44229187
43Circadian entrainment_Homo sapiens_hsa047131.43655528
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43638772
45Homologous recombination_Homo sapiens_hsa034401.41764903
46Fructose and mannose metabolism_Homo sapiens_hsa000511.41064607
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40886482
48Insulin secretion_Homo sapiens_hsa049111.39643873
49Oocyte meiosis_Homo sapiens_hsa041141.38516521
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38264548
51PPAR signaling pathway_Homo sapiens_hsa033201.28830583
52Salivary secretion_Homo sapiens_hsa049701.28365429
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28028633
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21970034
55Ether lipid metabolism_Homo sapiens_hsa005651.19206016
56Glutamatergic synapse_Homo sapiens_hsa047241.17814091
57Carbon metabolism_Homo sapiens_hsa012001.13976724
58Fat digestion and absorption_Homo sapiens_hsa049751.11819975
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09683217
60Calcium signaling pathway_Homo sapiens_hsa040201.08271610
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.06275623
62Taste transduction_Homo sapiens_hsa047421.04627754
63RNA degradation_Homo sapiens_hsa030181.04070514
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.03242883
65Proteasome_Homo sapiens_hsa030501.01665792
66Dopaminergic synapse_Homo sapiens_hsa047281.00714616
67Regulation of autophagy_Homo sapiens_hsa041401.00120832
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99403166
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.99187842
70Huntingtons disease_Homo sapiens_hsa050160.97614559
71Dorso-ventral axis formation_Homo sapiens_hsa043200.97516991
72Fatty acid metabolism_Homo sapiens_hsa012120.97362019
73Estrogen signaling pathway_Homo sapiens_hsa049150.95765290
74Hedgehog signaling pathway_Homo sapiens_hsa043400.94522356
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92521982
76Ovarian steroidogenesis_Homo sapiens_hsa049130.90730958
77Retinol metabolism_Homo sapiens_hsa008300.90667994
78Selenocompound metabolism_Homo sapiens_hsa004500.89894040
79Gastric acid secretion_Homo sapiens_hsa049710.88724808
80Olfactory transduction_Homo sapiens_hsa047400.87749569
81Type I diabetes mellitus_Homo sapiens_hsa049400.87413870
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.86332800
83ABC transporters_Homo sapiens_hsa020100.85583249
84Morphine addiction_Homo sapiens_hsa050320.85530878
85cAMP signaling pathway_Homo sapiens_hsa040240.84472083
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82495199
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80852246
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80506191
89Thyroid hormone synthesis_Homo sapiens_hsa049180.80462946
90Pentose phosphate pathway_Homo sapiens_hsa000300.78937007
91Fatty acid degradation_Homo sapiens_hsa000710.78307025
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77699912
93One carbon pool by folate_Homo sapiens_hsa006700.76245893
94Pancreatic secretion_Homo sapiens_hsa049720.74489106
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.73964445
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73720958
97Biosynthesis of amino acids_Homo sapiens_hsa012300.69812394
98Vibrio cholerae infection_Homo sapiens_hsa051100.69590420
99Cocaine addiction_Homo sapiens_hsa050300.69155310
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68937879
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68858656
102Bile secretion_Homo sapiens_hsa049760.67527727
103beta-Alanine metabolism_Homo sapiens_hsa004100.67314875
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.67180983
105Histidine metabolism_Homo sapiens_hsa003400.66997191
106Oxytocin signaling pathway_Homo sapiens_hsa049210.66991861
107Purine metabolism_Homo sapiens_hsa002300.65232885
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65077144
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64587260
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61726769
111Oxidative phosphorylation_Homo sapiens_hsa001900.61539014
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61049355
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59126696
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.58734032
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57415172
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57124836
117Arachidonic acid metabolism_Homo sapiens_hsa005900.53567448
118Inositol phosphate metabolism_Homo sapiens_hsa005620.53503162
119Glutathione metabolism_Homo sapiens_hsa004800.51244102
120GABAergic synapse_Homo sapiens_hsa047270.50751116
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50544003
122Graft-versus-host disease_Homo sapiens_hsa053320.50020770
123mRNA surveillance pathway_Homo sapiens_hsa030150.49725620
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.47398307
125Chemical carcinogenesis_Homo sapiens_hsa052040.47344032
126Vitamin digestion and absorption_Homo sapiens_hsa049770.46133444
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45437949
128Ribosome_Homo sapiens_hsa030100.44942846
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44776357
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44219428
131Non-homologous end-joining_Homo sapiens_hsa034500.42330135
132VEGF signaling pathway_Homo sapiens_hsa043700.41216958
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41112078
134RNA transport_Homo sapiens_hsa030130.41067515
135Alzheimers disease_Homo sapiens_hsa050100.40895126
136Fatty acid elongation_Homo sapiens_hsa000620.40499362
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39962556
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39829321
139Long-term depression_Homo sapiens_hsa047300.39486024
140Asthma_Homo sapiens_hsa053100.38705961
141Antigen processing and presentation_Homo sapiens_hsa046120.38675810
142Pyrimidine metabolism_Homo sapiens_hsa002400.38621200
143Renin-angiotensin system_Homo sapiens_hsa046140.38147161
144Sulfur relay system_Homo sapiens_hsa041220.38109030
145Endocytosis_Homo sapiens_hsa041440.35474683
146AMPK signaling pathway_Homo sapiens_hsa041520.32286422
147Alcoholism_Homo sapiens_hsa050340.32251639
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31684311
149Serotonergic synapse_Homo sapiens_hsa047260.30383403
150Metabolic pathways_Homo sapiens_hsa011000.29393321
151Circadian rhythm_Homo sapiens_hsa047100.26566768
152Type II diabetes mellitus_Homo sapiens_hsa049300.26442999

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