CSTF2T

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.37527184
2nuclear pore organization (GO:0006999)4.98696723
3mitotic chromosome condensation (GO:0007076)4.96686627
4DNA topological change (GO:0006265)4.67497801
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.61507620
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.50912655
7pore complex assembly (GO:0046931)4.50432499
8locomotory exploration behavior (GO:0035641)4.48618893
9protein complex localization (GO:0031503)4.40250644
10establishment of integrated proviral latency (GO:0075713)4.29895084
11regulation of synaptic vesicle exocytosis (GO:2000300)4.27704139
12cellular protein complex localization (GO:0034629)4.27218343
13neurotransmitter-gated ion channel clustering (GO:0072578)4.21644924
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.11529203
15vocalization behavior (GO:0071625)4.11329121
16heterochromatin organization (GO:0070828)4.10184354
17pre-miRNA processing (GO:0031054)4.05634351
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.98013001
193-UTR-mediated mRNA stabilization (GO:0070935)3.97713864
20RNA stabilization (GO:0043489)3.95472344
21mRNA stabilization (GO:0048255)3.95472344
22synaptic vesicle maturation (GO:0016188)3.94816165
23mitotic sister chromatid cohesion (GO:0007064)3.90236327
24glutamate secretion (GO:0014047)3.89042201
25regulation of synaptic vesicle transport (GO:1902803)3.81314522
26protein localization to synapse (GO:0035418)3.78165201
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.76971502
28inositol phosphate catabolic process (GO:0071545)3.76235452
29synaptic vesicle exocytosis (GO:0016079)3.74813427
30negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73974280
31neuron cell-cell adhesion (GO:0007158)3.73768534
32regulation of glutamate receptor signaling pathway (GO:1900449)3.73434265
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70288309
34spliceosomal tri-snRNP complex assembly (GO:0000244)3.69111395
35protein localization to chromosome, centromeric region (GO:0071459)3.69001847
36regulation of RNA export from nucleus (GO:0046831)3.66718829
37histone H3-K36 demethylation (GO:0070544)3.65765372
38mitotic metaphase plate congression (GO:0007080)3.59551121
39presynaptic membrane assembly (GO:0097105)3.59499340
40long-term synaptic potentiation (GO:0060291)3.54091345
41regulation of translational fidelity (GO:0006450)3.51918052
42sister chromatid segregation (GO:0000819)3.51762012
43positive regulation of synapse maturation (GO:0090129)3.51103605
44DNA strand elongation involved in DNA replication (GO:0006271)3.50835232
45protein localization to kinetochore (GO:0034501)3.47983389
46DNA strand elongation (GO:0022616)3.40379809
47regulation of synapse structural plasticity (GO:0051823)3.37283667
48synaptic vesicle endocytosis (GO:0048488)3.36895548
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.34219506
50regulation of nucleobase-containing compound transport (GO:0032239)3.33891935
51regulation of neuronal synaptic plasticity (GO:0048168)3.32987018
52DNA duplex unwinding (GO:0032508)3.29188531
53synaptic transmission, glutamatergic (GO:0035249)3.29044605
54exploration behavior (GO:0035640)3.28815183
55negative regulation of dendrite morphogenesis (GO:0050774)3.28767993
56formation of translation preinitiation complex (GO:0001731)3.28034952
57V(D)J recombination (GO:0033151)3.27397347
58establishment of viral latency (GO:0019043)3.27060033
59histone H3-K9 demethylation (GO:0033169)3.26310337
60regulation of dendritic spine morphogenesis (GO:0061001)3.23375703
61ionotropic glutamate receptor signaling pathway (GO:0035235)3.22822880
62negative regulation of hormone biosynthetic process (GO:0032353)3.18301469
63negative regulation of hormone metabolic process (GO:0032351)3.18301469
64DNA synthesis involved in DNA repair (GO:0000731)3.17724282
65regulation of mRNA stability (GO:0043488)3.16385598
66nucleosome disassembly (GO:0006337)3.16189891
67protein-DNA complex disassembly (GO:0032986)3.16189891
68layer formation in cerebral cortex (GO:0021819)3.16015947
69neurotransmitter secretion (GO:0007269)3.15110810
70negative regulation of erythrocyte differentiation (GO:0045647)3.14690978
71negative regulation of histone methylation (GO:0031061)3.14542515
72glutamate receptor signaling pathway (GO:0007215)3.12586532
73neuron-neuron synaptic transmission (GO:0007270)3.11752513
74postsynaptic membrane organization (GO:0001941)3.11287757
75membrane disassembly (GO:0030397)3.10932708
76nuclear envelope disassembly (GO:0051081)3.10932708
77ribosome assembly (GO:0042255)3.10404087
78axonal fasciculation (GO:0007413)3.07975263
79mitotic nuclear envelope disassembly (GO:0007077)3.07690469
80DNA geometric change (GO:0032392)3.06502853
81mitotic sister chromatid segregation (GO:0000070)3.06120675
82neuron recognition (GO:0008038)3.06063105
83regulation of histone H3-K9 methylation (GO:0051570)3.06054886
84dendritic spine morphogenesis (GO:0060997)3.03979206
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03056716
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02476727
87regulation of RNA stability (GO:0043487)3.01979806
88IMP metabolic process (GO:0046040)3.00806287
89presynaptic membrane organization (GO:0097090)2.99927218
90inositol phosphate dephosphorylation (GO:0046855)2.98100647
91phosphorylated carbohydrate dephosphorylation (GO:0046838)2.98100647
92regulation of transcription from RNA polymerase I promoter (GO:0006356)2.97602973
93positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97445473
94telomere maintenance via semi-conservative replication (GO:0032201)2.95517038
95regulation of excitatory postsynaptic membrane potential (GO:0060079)2.95511315
96positive regulation of gamma-delta T cell activation (GO:0046645)2.95460086
97cellular hyperosmotic response (GO:0071474)2.94488131
98negative regulation of RNA splicing (GO:0033119)2.91828211
99long-term memory (GO:0007616)2.91680349
100IMP biosynthetic process (GO:0006188)2.91295282
101negative regulation of mRNA metabolic process (GO:1903312)2.90258377
102regulation of synaptic plasticity (GO:0048167)2.90126119
103vesicle transport along microtubule (GO:0047496)2.90075835
104gamma-aminobutyric acid transport (GO:0015812)2.88406546
105embryonic process involved in female pregnancy (GO:0060136)2.88140996
106chromatin assembly (GO:0031497)2.86955571
107establishment of nucleus localization (GO:0040023)2.85346366
108positive regulation of membrane potential (GO:0045838)2.83515370
109long term synaptic depression (GO:0060292)2.83280955
110negative regulation of mRNA processing (GO:0050686)2.82743727
111dendritic spine organization (GO:0097061)2.80769077
112regulation of postsynaptic membrane potential (GO:0060078)2.79398535
113ATP-dependent chromatin remodeling (GO:0043044)2.79100482
114striatum development (GO:0021756)2.78397392
115intracellular estrogen receptor signaling pathway (GO:0030520)2.78347617
116behavioral fear response (GO:0001662)2.76748430
117behavioral defense response (GO:0002209)2.76748430
118DNA replication initiation (GO:0006270)2.76244279
119innervation (GO:0060384)2.76071784
120DNA conformation change (GO:0071103)2.75333577
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.71476127
122regulation of chromatin binding (GO:0035561)2.69917221
123metaphase plate congression (GO:0051310)2.69572897
124establishment of chromosome localization (GO:0051303)2.66830172
125proline transport (GO:0015824)2.65953864
126protein export from nucleus (GO:0006611)2.65394933
127regulation of mitotic spindle organization (GO:0060236)2.65216039
128regulation of helicase activity (GO:0051095)2.65102604
129positive regulation of SMAD protein import into nucleus (GO:0060391)2.64352856
130chromatin assembly or disassembly (GO:0006333)2.63866474
131G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63272876
132mRNA transport (GO:0051028)2.62327576
133peptidyl-arginine omega-N-methylation (GO:0035247)2.61288204
134cell communication by electrical coupling (GO:0010644)2.60618266
135nuclear envelope organization (GO:0006998)2.60209108
136negative regulation of dendrite development (GO:2000171)2.59907173
137positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59834325
138cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59275805
139RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.58608255
140mRNA splicing, via spliceosome (GO:0000398)2.58608255
141chromosome condensation (GO:0030261)2.58277059
142cerebellar Purkinje cell differentiation (GO:0021702)2.58126634
143regulation of DNA damage checkpoint (GO:2000001)2.57568864
144dosage compensation (GO:0007549)2.57430587
145cerebellum development (GO:0021549)2.57262610
146synapse assembly (GO:0007416)2.56839347
147histone demethylation (GO:0016577)2.56763447
148gamma-aminobutyric acid signaling pathway (GO:0007214)2.56169125
149glucocorticoid receptor signaling pathway (GO:0042921)2.56073004
150protein demethylation (GO:0006482)2.52971348
151protein dealkylation (GO:0008214)2.52971348
152regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.52942546
153dendrite morphogenesis (GO:0048813)2.51652626
154pentose-phosphate shunt (GO:0006098)2.51394758
155regulation of dendritic spine development (GO:0060998)2.51291737
156telomere maintenance via recombination (GO:0000722)2.50796914
157RNA splicing, via transesterification reactions (GO:0000375)2.50364780
158regulation of synaptic transmission, glutamatergic (GO:0051966)2.50030807
159organelle transport along microtubule (GO:0072384)2.49042392
160mitotic recombination (GO:0006312)2.48982830
161negative regulation of DNA repair (GO:0045738)2.48611058
162negative regulation of gene expression, epigenetic (GO:0045814)2.48221248
163histone H4-K16 acetylation (GO:0043984)2.47675709
164paraxial mesoderm development (GO:0048339)2.47572444
165positive regulation of chromosome segregation (GO:0051984)2.47311616
166learning (GO:0007612)2.47203923
167cerebellar granule cell differentiation (GO:0021707)2.47054039
168regulation of neurotransmitter secretion (GO:0046928)2.46099980
169histone H2B ubiquitination (GO:0033523)2.45217103
170neuronal action potential propagation (GO:0019227)2.45100448
171transmission of nerve impulse (GO:0019226)2.45011522
172regulation of spindle organization (GO:0090224)2.44837648
173fear response (GO:0042596)2.44723163
174cellular potassium ion homeostasis (GO:0030007)2.44423613
175ribosomal small subunit biogenesis (GO:0042274)2.44042352
176regulation of gamma-delta T cell differentiation (GO:0045586)2.43820457
177central nervous system projection neuron axonogenesis (GO:0021952)2.43623419
178retinal rod cell development (GO:0046548)2.43296517
179mRNA splice site selection (GO:0006376)2.41862108
180regulation of synapse maturation (GO:0090128)2.40984804
181regulation of female receptivity (GO:0045924)2.40766699
182histone lysine demethylation (GO:0070076)2.40742704
183DNA replication-independent nucleosome assembly (GO:0006336)2.40155704
184DNA replication-independent nucleosome organization (GO:0034724)2.40155704
185ribosomal large subunit biogenesis (GO:0042273)2.39912373
186regulation of sister chromatid cohesion (GO:0007063)2.39673268
187DNA ligation (GO:0006266)2.39213211
188non-recombinational repair (GO:0000726)2.38534614
189positive regulation of dendritic spine morphogenesis (GO:0061003)2.38492060
190startle response (GO:0001964)2.37564316
191regulation of NFAT protein import into nucleus (GO:0051532)2.36753134
192G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.32610097
193dendrite development (GO:0016358)2.30345659
194regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29856869
195nuclear pore complex assembly (GO:0051292)2.28525766
196activation of protein kinase A activity (GO:0034199)2.27872271
197hippocampus development (GO:0021766)2.26831279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.65968923
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.65201639
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.64776255
4EZH2_22144423_ChIP-Seq_EOC_Human3.55686038
5MYC_22102868_ChIP-Seq_BL_Human3.52495382
6GBX2_23144817_ChIP-Seq_PC3_Human3.44787707
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.35858868
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21858189
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16634875
10* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.12715603
11* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79993783
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.58594179
13* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52770584
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43626136
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42818855
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.38632531
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.32617267
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31798020
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28184049
20VDR_21846776_ChIP-Seq_THP-1_Human2.27322550
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26183374
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26074163
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.24128916
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.19417820
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14400410
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12057329
27FUS_26573619_Chip-Seq_HEK293_Human2.10766193
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.10470884
29* E2F1_21310950_ChIP-Seq_MCF-7_Human2.10302209
30* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.04308212
31AR_21572438_ChIP-Seq_LNCaP_Human2.01130310
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95568593
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88763427
34SMAD4_21799915_ChIP-Seq_A2780_Human1.88569372
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86567224
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86412665
37REST_21632747_ChIP-Seq_MESCs_Mouse1.84048293
38XRN2_22483619_ChIP-Seq_HELA_Human1.82392033
39* P300_19829295_ChIP-Seq_ESCs_Human1.81174672
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78434119
41TCF7_22412390_ChIP-Seq_EML_Mouse1.76617747
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75801467
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75006579
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72426042
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71493115
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71139977
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71130229
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70131030
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69151211
50CLOCK_20551151_ChIP-Seq_293T_Human1.68780478
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68490174
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67769860
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67612809
54* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67591168
55* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67016449
56* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64935310
57* MAF_26560356_Chip-Seq_TH1_Human1.63173476
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62848116
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62002592
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60804956
61STAT3_23295773_ChIP-Seq_U87_Human1.59820527
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.59780663
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59589184
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57365918
65AR_21909140_ChIP-Seq_LNCAP_Human1.57051309
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56726654
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56169195
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56169195
69KDM2B_26808549_Chip-Seq_DND41_Human1.55750429
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.55609728
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54932676
72E2F7_22180533_ChIP-Seq_HELA_Human1.54835116
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.54349333
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53920104
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52014236
76GATA1_22025678_ChIP-Seq_K562_Human1.48986326
77DROSHA_22980978_ChIP-Seq_HELA_Human1.48713076
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46418510
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46235554
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.45792317
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45627008
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45587138
83AR_25329375_ChIP-Seq_VCAP_Human1.45536230
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45174161
85* REST_18959480_ChIP-ChIP_MESCs_Mouse1.44874258
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43813785
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.42881966
88* CIITA_25753668_ChIP-Seq_RAJI_Human1.42125577
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42068668
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37375313
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37370093
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36833621
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36575615
94EWS_26573619_Chip-Seq_HEK293_Human1.36441291
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35524133
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.34913990
97* UTX_26944678_Chip-Seq_JUKART_Human1.34473727
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34296074
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33609997
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32850845
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.31829945
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31496529
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31447338
104* CHD1_26751641_Chip-Seq_LNCaP_Human1.31347696
105RNF2_27304074_Chip-Seq_NSC_Mouse1.31220663
106TCF4_23295773_ChIP-Seq_U87_Human1.31071013
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30772955
108TAF15_26573619_Chip-Seq_HEK293_Human1.30413822
109AR_19668381_ChIP-Seq_PC3_Human1.30405105
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29843940
111SOX9_26525672_Chip-Seq_HEART_Mouse1.29267720
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29070360
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29068304
114TTF2_22483619_ChIP-Seq_HELA_Human1.29025855
115ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28854959
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28849080
117KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28460357
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28443166
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28002447
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27881264
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27250050
122ELK3_25401928_ChIP-Seq_HUVEC_Human1.26449916
123FOXM1_23109430_ChIP-Seq_U2OS_Human1.26020957
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25997943
125KDM2B_26808549_Chip-Seq_JURKAT_Human1.25845889
126ZNF274_21170338_ChIP-Seq_K562_Hela1.25809881
127TP53_16413492_ChIP-PET_HCT116_Human1.25496028
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25173791
129EED_16625203_ChIP-ChIP_MESCs_Mouse1.24316196
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24130404
131JUN_21703547_ChIP-Seq_K562_Human1.23866583
132MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23084229
133SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22168462
134NANOG_21062744_ChIP-ChIP_HESCs_Human1.21860519
135AHR_22903824_ChIP-Seq_MCF-7_Human1.21553467
136* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20773482
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20325706
138PIAS1_25552417_ChIP-Seq_VCAP_Human1.19333719
139DCP1A_22483619_ChIP-Seq_HELA_Human1.18736270
140ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18009652
141NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17844468
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17407528
143CBX2_27304074_Chip-Seq_ESCs_Mouse1.17315939
144ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16862112
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16711318
146P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16655534
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16606022
148ER_23166858_ChIP-Seq_MCF-7_Human1.15684687
149FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15334404
150BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15210631
151RXR_22108803_ChIP-Seq_LS180_Human1.14856670
152PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14422335
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14403337
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14397161
155NANOG_18555785_Chip-Seq_ESCs_Mouse1.14201032
156KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13809085
157KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13809085
158KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13809085
159EZH2_27294783_Chip-Seq_ESCs_Mouse1.13506627
160MAF_26560356_Chip-Seq_TH2_Human1.13045849
161NCOR1_26117541_ChIP-Seq_K562_Human1.12921735
162* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12701055
163* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11893977
164FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11473532
165TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11085369
166* MYB_26560356_Chip-Seq_TH2_Human1.10806554
167GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10614353
168CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10488759
169HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10365800
170P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08251239
171* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08102833
172EP300_21415370_ChIP-Seq_HL-1_Mouse1.07545002
173FLI1_27457419_Chip-Seq_LIVER_Mouse1.07507605
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07039183
175TFEB_21752829_ChIP-Seq_HELA_Human1.05829915
176RUNX2_22187159_ChIP-Seq_PCA_Human1.05809315
177* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05585947
178NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05012670
179PRDM14_20953172_ChIP-Seq_ESCs_Human1.03947635
180HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03727625
181KDM5A_27292631_Chip-Seq_BREAST_Human1.03721962
182* MYB_26560356_Chip-Seq_TH1_Human1.03095958
183PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03094758
184E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02497926
185SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02239657
186SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00714507
187TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00377813
188* VDR_24763502_ChIP-Seq_THP-1_Human0.99467523
189SPI1_23547873_ChIP-Seq_NB4_Human0.98291885
190FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97351360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.05267807
2MP0008057_abnormal_DNA_replication3.98394452
3MP0003880_abnormal_central_pattern3.61115520
4MP0003111_abnormal_nucleus_morphology3.38649777
5MP0004957_abnormal_blastocyst_morpholog3.17897349
6MP0003787_abnormal_imprinting3.15381902
7MP0003635_abnormal_synaptic_transmissio3.12695217
8MP0003693_abnormal_embryo_hatching3.08795498
9MP0010094_abnormal_chromosome_stability3.06818793
10MP0003077_abnormal_cell_cycle2.93158193
11MP0001984_abnormal_olfaction2.87439756
12MP0002063_abnormal_learning/memory/cond2.78621815
13MP0004270_analgesia2.75567644
14MP0005394_taste/olfaction_phenotype2.54283783
15MP0005499_abnormal_olfactory_system2.54283783
16MP0003123_paternal_imprinting2.49135351
17MP0003705_abnormal_hypodermis_morpholog2.48102993
18MP0009745_abnormal_behavioral_response2.35650300
19MP0002396_abnormal_hematopoietic_system2.35213465
20MP0001730_embryonic_growth_arrest2.27692156
21MP0004185_abnormal_adipocyte_glucose2.26669433
22MP0003122_maternal_imprinting2.25649442
23MP0003121_genomic_imprinting2.22581586
24MP0009278_abnormal_bone_marrow2.22195716
25MP0005076_abnormal_cell_differentiation2.18459445
26MP0003763_abnormal_thymus_physiology2.13602303
27MP0009780_abnormal_chondrocyte_physiolo2.13541256
28MP0000778_abnormal_nervous_system2.12751311
29MP0000350_abnormal_cell_proliferation2.10175748
30MP0010352_gastrointestinal_tract_polyps2.09041465
31MP0009046_muscle_twitch2.00055441
32MP0003828_pulmonary_edema1.99836534
33MP0009672_abnormal_birth_weight1.99818302
34MP0002064_seizures1.99677279
35MP0002734_abnormal_mechanical_nocicepti1.96186340
36MP0002572_abnormal_emotion/affect_behav1.95144072
37MP0008932_abnormal_embryonic_tissue1.93403128
38MP0004808_abnormal_hematopoietic_stem1.92248456
39MP0005423_abnormal_somatic_nervous1.89917880
40MP0003221_abnormal_cardiomyocyte_apopto1.89451497
41MP0005451_abnormal_body_composition1.85972648
42MP0003303_peritoneal_inflammation1.82635059
43MP0001968_abnormal_touch/_nociception1.81279786
44MP0003300_gastrointestinal_ulcer1.77147827
45MP0008789_abnormal_olfactory_epithelium1.73978865
46MP0002736_abnormal_nociception_after1.67286088
47MP0002272_abnormal_nervous_system1.67038090
48MP0004811_abnormal_neuron_physiology1.65680077
49MP0001188_hyperpigmentation1.65618964
50MP0002877_abnormal_melanocyte_morpholog1.63665237
51MP0005380_embryogenesis_phenotype1.63474066
52MP0001672_abnormal_embryogenesis/_devel1.63474066
53MP0008058_abnormal_DNA_repair1.61794764
54MP0000751_myopathy1.61031404
55MP0001486_abnormal_startle_reflex1.61004324
56MP0008877_abnormal_DNA_methylation1.60093374
57MP0003984_embryonic_growth_retardation1.59650798
58MP0000747_muscle_weakness1.57943722
59MP0001849_ear_inflammation1.55788115
60MP0001501_abnormal_sleep_pattern1.55659785
61MP0006292_abnormal_olfactory_placode1.55480502
62MP0000703_abnormal_thymus_morphology1.53804780
63MP0001177_atelectasis1.53672518
64MP0002088_abnormal_embryonic_growth/wei1.53200227
65MP0004885_abnormal_endolymph1.51656933
66MP0002184_abnormal_innervation1.51149392
67MP0002080_prenatal_lethality1.49944144
68MP0000490_abnormal_crypts_of1.48950114
69MP0002009_preneoplasia1.45698811
70MP0002086_abnormal_extraembryonic_tissu1.44367751
71MP0004197_abnormal_fetal_growth/weight/1.41051134
72MP0002085_abnormal_embryonic_tissue1.40688842
73MP0001697_abnormal_embryo_size1.40596855
74MP0003091_abnormal_cell_migration1.39998540
75MP0005646_abnormal_pituitary_gland1.39894901
76MP0005386_behavior/neurological_phenoty1.32038023
77MP0004924_abnormal_behavior1.32038023
78MP0002084_abnormal_developmental_patter1.31963941
79MP0002067_abnormal_sensory_capabilities1.31550373
80MP0000733_abnormal_muscle_development1.30936010
81MP0002398_abnormal_bone_marrow1.30906609
82MP0008260_abnormal_autophagy1.28382287
83MP0004233_abnormal_muscle_weight1.28375087
84MP0002882_abnormal_neuron_morphology1.28111799
85MP0002557_abnormal_social/conspecific_i1.26316662
86MP0008007_abnormal_cellular_replicative1.25971854
87MP0000313_abnormal_cell_death1.25965135
88MP0005551_abnormal_eye_electrophysiolog1.25510730
89MP0005171_absent_coat_pigmentation1.25438027
90MP0008569_lethality_at_weaning1.24482340
91MP0002152_abnormal_brain_morphology1.23301063
92MP0001502_abnormal_circadian_rhythm1.20195491
93MP0005621_abnormal_cell_physiology1.18249692
94MP0002822_catalepsy1.16727163
95MP0010630_abnormal_cardiac_muscle1.16325862
96MP0000955_abnormal_spinal_cord1.15922093
97MP0004087_abnormal_muscle_fiber1.15079165
98MP0003566_abnormal_cell_adhesion1.11480685
99MP0003941_abnormal_skin_development1.10605838
100MP0003890_abnormal_embryonic-extraembry1.09538810
101MP0002722_abnormal_immune_system1.09391876
102MP0002092_abnormal_eye_morphology1.09365476
103MP0003861_abnormal_nervous_system1.09010943
104MP0003385_abnormal_body_wall1.08865441
105MP0004085_abnormal_heartbeat1.08769949
106MP0009703_decreased_birth_body1.06994008
107MP0002735_abnormal_chemical_nociception1.06915844
108MP0000759_abnormal_skeletal_muscle1.05793917
109MP0004215_abnormal_myocardial_fiber1.05634094
110MP0001293_anophthalmia1.05274493
111MP0004858_abnormal_nervous_system1.04137679
112MP0005666_abnormal_adipose_tissue1.04028389
113MP0002697_abnormal_eye_size1.03924543
114MP0003115_abnormal_respiratory_system1.03459603
115MP0000516_abnormal_urinary_system1.02859817
116MP0005367_renal/urinary_system_phenotyp1.02859817
117MP0001727_abnormal_embryo_implantation1.00523048
118MP0005187_abnormal_penis_morphology1.00488432
119MP0003436_decreased_susceptibility_to1.00472655
120MP0001346_abnormal_lacrimal_gland0.99838153
121MP0000631_abnormal_neuroendocrine_gland0.99412429
122MP0004947_skin_inflammation0.99046490
123MP0006072_abnormal_retinal_apoptosis0.98829265
124MP0000689_abnormal_spleen_morphology0.98118431
125MP0001915_intracranial_hemorrhage0.97411502
126MP0002019_abnormal_tumor_incidence0.95119962
127MP0002066_abnormal_motor_capabilities/c0.94145817
128MP0003453_abnormal_keratinocyte_physiol0.93700552
129MP0005623_abnormal_meninges_morphology0.93140499
130MP0001986_abnormal_taste_sensitivity0.91990025
131MP0003119_abnormal_digestive_system0.91565767
132MP0003315_abnormal_perineum_morphology0.91097555
133MP0009333_abnormal_splenocyte_physiolog0.90281021
134MP0005384_cellular_phenotype0.89341177
135MP0010307_abnormal_tumor_latency0.89016411
136MP0003632_abnormal_nervous_system0.88857014
137MP0005253_abnormal_eye_physiology0.88445168
138MP0003755_abnormal_palate_morphology0.87612382
139MP0002254_reproductive_system_inflammat0.85433885
140MP0004264_abnormal_extraembryonic_tissu0.84694045
141MP0002405_respiratory_system_inflammati0.84195738
142MP0005248_abnormal_Harderian_gland0.84023833
143MP0002429_abnormal_blood_cell0.83864169
144MP0000716_abnormal_immune_system0.83790097
145MP0001529_abnormal_vocalization0.83489036
146MP0001440_abnormal_grooming_behavior0.82788628
147MP0002160_abnormal_reproductive_system0.82456132
148MP0002233_abnormal_nose_morphology0.82208415
149MP0003631_nervous_system_phenotype0.81403503
150MP0004484_altered_response_of0.78705286
151MP0002752_abnormal_somatic_nervous0.78123707
152MP0002332_abnormal_exercise_endurance0.76614651
153MP0002909_abnormal_adrenal_gland0.74073131
154MP0001970_abnormal_pain_threshold0.73909507
155MP0003633_abnormal_nervous_system0.73572528
156MP0003567_abnormal_fetal_cardiomyocyte0.73367701
157MP0002420_abnormal_adaptive_immunity0.73213160
158MP0001819_abnormal_immune_cell0.73164884
159MP0005000_abnormal_immune_tolerance0.72846913
160MP0002081_perinatal_lethality0.71990622
161MP0005397_hematopoietic_system_phenotyp0.71755006
162MP0001545_abnormal_hematopoietic_system0.71755006
163MP0003937_abnormal_limbs/digits/tail_de0.71606339
164MP0000534_abnormal_ureter_morphology0.71164415
165MP0003690_abnormal_glial_cell0.70853238
166MP0002837_dystrophic_cardiac_calcinosis0.70655856
167MP0002111_abnormal_tail_morphology0.70312846
168MP0002269_muscular_atrophy0.69722025
169MP0002653_abnormal_ependyma_morphology0.69644796
170MP0001800_abnormal_humoral_immune0.69498108
171MP0006138_congestive_heart_failure0.69450140
172MP0000465_gastrointestinal_hemorrhage0.69440689
173MP0001963_abnormal_hearing_physiology0.69102566
174MP0000428_abnormal_craniofacial_morphol0.68851539
175MP0002733_abnormal_thermal_nociception0.68564473
176MP0001286_abnormal_eye_development0.67580516
177MP0000685_abnormal_immune_system0.66927862
178MP0002229_neurodegeneration0.66182426
179MP0003943_abnormal_hepatobiliary_system0.65609586
180MP0000432_abnormal_head_morphology0.65347133
181MP0001299_abnormal_eye_distance/0.65296571
182MP0003448_altered_tumor_morphology0.65292683
183MP0004145_abnormal_muscle_electrophysio0.64639783
184MP0002638_abnormal_pupillary_reflex0.64626596
185MP0000537_abnormal_urethra_morphology0.63623481
186MP0010234_abnormal_vibrissa_follicle0.63553385
187MP0000569_abnormal_digit_pigmentation0.63415913
188MP0002127_abnormal_cardiovascular_syste0.62980601
189MP0002166_altered_tumor_susceptibility0.62962872

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.50002962
2Focal motor seizures (HP:0011153)4.49259283
3Abnormality of the lower motor neuron (HP:0002366)3.69124784
4Progressive muscle weakness (HP:0003323)3.23952787
5Focal seizures (HP:0007359)3.17698476
6Atonic seizures (HP:0010819)3.16551084
7Thyroid carcinoma (HP:0002890)3.10819536
8Centrally nucleated skeletal muscle fibers (HP:0003687)3.10470157
9Epileptic encephalopathy (HP:0200134)3.06392325
10Visual hallucinations (HP:0002367)3.05306997
11Febrile seizures (HP:0002373)3.04147428
12Spastic diplegia (HP:0001264)2.95154321
13Hepatoblastoma (HP:0002884)2.92933559
14Neoplasm of the adrenal cortex (HP:0100641)2.91522069
15Asymmetry of the thorax (HP:0001555)2.82143507
16Abnormality of the labia minora (HP:0012880)2.79796654
17Pelvic girdle muscle weakness (HP:0003749)2.78886718
18Absence seizures (HP:0002121)2.75483173
19Cortical dysplasia (HP:0002539)2.69909999
20Missing ribs (HP:0000921)2.69116481
21Abnormality of the calcaneus (HP:0008364)2.68822357
22Progressive external ophthalmoplegia (HP:0000590)2.67316988
23Gait imbalance (HP:0002141)2.65377941
24Myokymia (HP:0002411)2.56919048
25Excessive salivation (HP:0003781)2.53358658
26Drooling (HP:0002307)2.53358658
27Progressive cerebellar ataxia (HP:0002073)2.50599897
28Nemaline bodies (HP:0003798)2.49685932
29Persistence of primary teeth (HP:0006335)2.48101776
30Calcaneovalgus deformity (HP:0001848)2.36962562
31Congenital primary aphakia (HP:0007707)2.35911122
32Hyperacusis (HP:0010780)2.33905900
33Abnormality of skeletal muscle fiber size (HP:0012084)2.32704584
34Muscle fiber inclusion bodies (HP:0100299)2.30057259
35Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.29814437
36Abnormality of the left ventricular outflow tract (HP:0011103)2.27808091
37Subaortic stenosis (HP:0001682)2.27808091
38Deep philtrum (HP:0002002)2.27681143
39Viral hepatitis (HP:0006562)2.27277552
40Increased connective tissue (HP:0009025)2.25806707
41Dialeptic seizures (HP:0011146)2.25184349
42Generalized tonic-clonic seizures (HP:0002069)2.23865173
43Short 4th metacarpal (HP:0010044)2.23672562
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23672562
45Multiple enchondromatosis (HP:0005701)2.23624325
46Peripheral hypomyelination (HP:0007182)2.21510020
47IgM deficiency (HP:0002850)2.21144162
48Upper motor neuron abnormality (HP:0002127)2.18574393
49Medulloblastoma (HP:0002885)2.18185699
50Impaired vibration sensation in the lower limbs (HP:0002166)2.17051297
51Pheochromocytoma (HP:0002666)2.16689337
52Reticulocytopenia (HP:0001896)2.16432893
53Hyperventilation (HP:0002883)2.16142014
54Poor coordination (HP:0002370)2.15770860
55Aqueductal stenosis (HP:0002410)2.15066308
56Mutism (HP:0002300)2.14985073
57Cystic hygroma (HP:0000476)2.13523524
58Abnormality of the fingertips (HP:0001211)2.10826811
59Abnormality of the hip-girdle musculature (HP:0001445)2.09223942
60Abnormality of the musculature of the pelvis (HP:0001469)2.09223942
61Protruding tongue (HP:0010808)2.06583332
62Broad-based gait (HP:0002136)2.03978562
63Cellulitis (HP:0100658)2.03958939
64Nephrogenic diabetes insipidus (HP:0009806)2.03375148
65Neoplasm of the adrenal gland (HP:0100631)2.02470424
66Rimmed vacuoles (HP:0003805)2.01726150
67Poor eye contact (HP:0000817)2.01570862
68Insomnia (HP:0100785)2.01220582
69Impaired smooth pursuit (HP:0007772)2.01031202
70T lymphocytopenia (HP:0005403)2.00558281
71Overlapping toe (HP:0001845)2.00234263
72Blue irides (HP:0000635)1.99613757
73Embryonal renal neoplasm (HP:0011794)1.98727998
74Deviation of the thumb (HP:0009603)1.98655078
75Increased variability in muscle fiber diameter (HP:0003557)1.98612712
76Abnormality of chromosome segregation (HP:0002916)1.98572684
77Medial flaring of the eyebrow (HP:0010747)1.98279249
78Genetic anticipation (HP:0003743)1.96164989
79Proximal placement of thumb (HP:0009623)1.96048727
80Absent eyebrow (HP:0002223)1.95573648
81Abnormality of the columella (HP:0009929)1.95360650
82Skull defect (HP:0001362)1.95023695
83Heterochromia iridis (HP:0001100)1.94776480
84Urethral obstruction (HP:0000796)1.93964101
85Gaze-evoked nystagmus (HP:0000640)1.93802823
86Distal lower limb amyotrophy (HP:0008944)1.92988378
87Abnormality of the distal phalanx of the thumb (HP:0009617)1.91906699
88Thin ribs (HP:0000883)1.91031624
89Generalized hypotonia (HP:0001290)1.90957940
90Basal cell carcinoma (HP:0002671)1.90446167
91Amblyopia (HP:0000646)1.90077777
92Increased nuchal translucency (HP:0010880)1.90064923
93Bowel incontinence (HP:0002607)1.89711929
94Central scotoma (HP:0000603)1.89573033
95Slow saccadic eye movements (HP:0000514)1.89554669
96Truncal ataxia (HP:0002078)1.89406686
97Action tremor (HP:0002345)1.88435821
98Long eyelashes (HP:0000527)1.88395866
99Neuroendocrine neoplasm (HP:0100634)1.88037153
100Thoracolumbar scoliosis (HP:0002944)1.87912898
101Fetal akinesia sequence (HP:0001989)1.86910364
102Abnormality of the astrocytes (HP:0100707)1.85734061
103Astrocytoma (HP:0009592)1.85734061
104Deep palmar crease (HP:0006191)1.85664902
105Exercise-induced myalgia (HP:0003738)1.84424796
106Absent speech (HP:0001344)1.83645132
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83599077
108Recurrent viral infections (HP:0004429)1.82217971
109Dysdiadochokinesis (HP:0002075)1.82034852
110Neoplasm of the thyroid gland (HP:0100031)1.81088148
111High anterior hairline (HP:0009890)1.80807868
112Pointed chin (HP:0000307)1.80266006
113Myopathic facies (HP:0002058)1.79967075
114Mitral valve prolapse (HP:0001634)1.79866291
115Acute lymphatic leukemia (HP:0006721)1.79748228
116Abnormality of ocular smooth pursuit (HP:0000617)1.79678736
117Lower limb asymmetry (HP:0100559)1.79008535
118Shoulder girdle muscle weakness (HP:0003547)1.78719458
119Trigonocephaly (HP:0000243)1.78504374
120Metaphyseal cupping (HP:0003021)1.78235221
121Ankyloglossia (HP:0010296)1.77644874
122Genital tract atresia (HP:0001827)1.77341592
123Deformed tarsal bones (HP:0008119)1.76222442
124Urinary bladder sphincter dysfunction (HP:0002839)1.75120030
125Decreased motor nerve conduction velocity (HP:0003431)1.74888372
126Vertebral arch anomaly (HP:0008438)1.74861642
127Gastrointestinal carcinoma (HP:0002672)1.73395392
128Malignant gastrointestinal tract tumors (HP:0006749)1.73395392
129Abnormal large intestine physiology (HP:0012700)1.73143753
130Difficulty running (HP:0009046)1.73039768
131Abnormality of oral frenula (HP:0000190)1.72660981
132Colitis (HP:0002583)1.71512804
133Selective tooth agenesis (HP:0001592)1.71465838
134Complete atrioventricular canal defect (HP:0001674)1.71048131
135Dysphonia (HP:0001618)1.70616104
136Urinary urgency (HP:0000012)1.70276751
137Diastasis recti (HP:0001540)1.69635005
138Premature loss of primary teeth (HP:0006323)1.69558581
139IgA deficiency (HP:0002720)1.69346140
140Vaginal atresia (HP:0000148)1.68208282
141Panhypogammaglobulinemia (HP:0003139)1.67926207
142Papilledema (HP:0001085)1.66353079
143Amyotrophic lateral sclerosis (HP:0007354)1.64888621
144Specific learning disability (HP:0001328)1.64846683
145Short palpebral fissure (HP:0012745)1.64660170
146Distal arthrogryposis (HP:0005684)1.64457878
147Hammertoe (HP:0001765)1.63209335
148Difficulty climbing stairs (HP:0003551)1.62537476
149Micropenis (HP:0000054)1.62455565
150Pseudobulbar signs (HP:0002200)1.62383017
151Sandal gap (HP:0001852)1.60961656
152Achilles tendon contracture (HP:0001771)1.60211552
153Abnormality of the corticospinal tract (HP:0002492)1.60190292
154Depression (HP:0000716)1.60066336
155Impaired social interactions (HP:0000735)1.59890185
156Abnormal social behavior (HP:0012433)1.59890185
157Glioma (HP:0009733)1.59472997
158Abnormality of the salivary glands (HP:0010286)1.59262764
159Epileptiform EEG discharges (HP:0011182)1.59200585
160Abnormality of cells of the erythroid lineage (HP:0012130)1.58868010
161Long palpebral fissure (HP:0000637)1.58746086
162Chorioretinal atrophy (HP:0000533)1.58123795
163Eczematoid dermatitis (HP:0000976)1.58055033
164Termporal pattern (HP:0011008)1.57948757
165Insidious onset (HP:0003587)1.57948757
166Fibular aplasia (HP:0002990)1.57575011
167Neoplasm of the peripheral nervous system (HP:0100007)1.57099951
168Abnormality of the 4th metacarpal (HP:0010012)1.57083779
169Leiomyosarcoma (HP:0100243)1.55595482
170Uterine leiomyosarcoma (HP:0002891)1.55595482
171Cutaneous melanoma (HP:0012056)1.55106843
172Arnold-Chiari malformation (HP:0002308)1.54975681
173Abnormal hair whorl (HP:0010721)1.54823335
174Aplasia/Hypoplasia of the sternum (HP:0006714)1.54806283
175Atrioventricular canal defect (HP:0006695)1.53330048
176Enlarged penis (HP:0000040)1.53266027
177Lower limb amyotrophy (HP:0007210)1.52299808
178Spinal canal stenosis (HP:0003416)1.52178576
179Abnormality of salivation (HP:0100755)1.51454652
180Omphalocele (HP:0001539)1.50791542
181EEG with generalized epileptiform discharges (HP:0011198)1.50000344
182Spinal cord lesions (HP:0100561)1.49725805
183Syringomyelia (HP:0003396)1.49725805
184Subacute progressive viral hepatitis (HP:0006572)1.49007737
185Stereotypic behavior (HP:0000733)1.48946447
186Dysmetric saccades (HP:0000641)1.48668610
187Nephroblastoma (Wilms tumor) (HP:0002667)1.48625398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.94402246
2NTRK33.74583094
3MAP3K103.73296920
4ERBB32.97399581
5EPHA42.96837459
6KSR12.75279102
7FRK2.68955895
8PRPF4B2.60006040
9BRD42.59744655
10AKT32.53766736
11MARK12.49035707
12SGK22.38824926
13MAP3K42.36563143
14PRKD32.34067765
15TAF12.31839615
16PLK22.15998694
17CASK2.15516229
18MINK12.12605652
19EEF2K2.11022932
20TRIB32.08788177
21MAP2K72.07414792
22TSSK62.03371015
23ICK1.93113338
24CDK61.80442069
25SGK2231.78798465
26SGK4941.78798465
27SGK31.70234757
28TTK1.67317971
29LATS21.62788897
30MAP3K91.59985729
31KSR21.54335417
32PLK31.51343523
33CDK41.51250776
34BRSK21.49188568
35SIK31.46275336
36FGFR41.43979267
37BMPR21.41154416
38RPS6KB21.39210626
39PAK61.38842893
40TTN1.38785885
41BRSK11.38043773
42MAP3K131.36510850
43NEK61.30877233
44MAPK131.29826919
45PBK1.29089087
46MAP3K141.29027338
47DAPK21.28426959
48DYRK31.28162431
49CCNB11.22802650
50CDK121.19030956
51ZAK1.17240648
52PASK1.15942263
53VRK21.10794042
54CAMKK11.10768891
55NTRK21.09830016
56PDK31.09802388
57PDK41.09802388
58NEK11.08160417
59STK381.06865181
60BUB11.05341704
61MAP2K40.99682847
62NME20.99619267
63RAF10.98845826
64PAK30.92773698
65CHEK10.88084380
66CDK80.87821659
67SGK10.86963490
68FGFR20.86468454
69SRPK10.85863409
70PRKCH0.84363169
71BCR0.83360094
72MAP4K10.81898769
73CDC70.80941684
74ATR0.79922221
75PRKCG0.78076981
76CDK50.77587571
77MAP2K20.77136373
78TAOK10.75621264
79TNIK0.75479063
80NEK20.74430099
81MTOR0.74324299
82WEE10.73994245
83CDK180.73471971
84DAPK10.73269604
85DYRK1A0.72791789
86CAMK1D0.72780339
87CDK70.72452112
88MKNK10.72420507
89TAOK20.70351824
90MKNK20.69525423
91RPS6KA40.68754601
92MAP3K80.68493308
93EPHA30.68449963
94RIPK40.67776640
95PTK60.66905312
96NLK0.66793725
97PIM10.66146316
98RIPK10.65532657
99STK40.65351658
100MAP2K30.65034120
101LATS10.63570500
102MARK30.63367550
103CAMK2A0.63154886
104STK38L0.62728872
105NEK90.61972913
106ALK0.61817165
107CAMKK20.61358485
108RPS6KB10.61030979
109RPS6KC10.60861302
110RPS6KL10.60861302
111CDK20.60790172
112CDK150.60136427
113CDK30.58172050
114AURKB0.56674707
115CDK140.56123243
116SCYL20.55537211
117BMPR1B0.53994941
118PKN20.53824592
119PDGFRA0.53056207
120CLK10.52384052
121PAK40.51949585
122VRK10.51880635
123PDK20.51739849
124NTRK10.51604376
125RET0.50820790
126YES10.50314657
127IRAK30.48631564
128FER0.48540632
129EPHB10.48410623
130MAPK100.47760013
131IRAK20.47609422
132TYRO30.46479029
133MAP3K20.45779118
134CDK11A0.44570262
135CSK0.44415857
136PTK2B0.43796648
137RPS6KA30.43782822
138JAK10.43536644
139PINK10.43459578
140MARK20.43108304
141BTK0.42255668
142CHEK20.42252591
143JAK20.41752882
144SIK20.41627888
145EIF2AK20.41588984
146MAP3K60.41387532
147NME10.41292539
148MAP2K10.41038617
149UHMK10.40778782
150STK100.40317707
151PAK20.40076123
152RPS6KA20.39503843
153CDK90.39427684
154TYK20.39303504
155STK30.38932731
156STK160.38820666
157CSNK1G20.38590749
158SIK10.38584602
159TESK20.38403091
160PLK10.38209114
161RPS6KA10.37452604
162EIF2AK30.37021814
163CAMK40.36285470
164CDK10.36210123
165PRKCE0.36193861
166TRPM70.33888801
167CAMK2B0.32859399
168BRAF0.32465575
169PRKAA10.32366174

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.07468118
2DNA replication_Homo sapiens_hsa030303.00193408
3Synaptic vesicle cycle_Homo sapiens_hsa047212.63470222
4Long-term potentiation_Homo sapiens_hsa047202.56972801
5Spliceosome_Homo sapiens_hsa030402.55062648
6Olfactory transduction_Homo sapiens_hsa047402.38113455
7Mismatch repair_Homo sapiens_hsa034302.37291785
8Circadian entrainment_Homo sapiens_hsa047132.34537809
9GABAergic synapse_Homo sapiens_hsa047272.27947887
10Morphine addiction_Homo sapiens_hsa050322.19326048
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16261277
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14224891
13Glutamatergic synapse_Homo sapiens_hsa047242.05271302
14Amphetamine addiction_Homo sapiens_hsa050311.99767157
15Dopaminergic synapse_Homo sapiens_hsa047281.88707194
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88640625
17Acute myeloid leukemia_Homo sapiens_hsa052211.84260785
18RNA transport_Homo sapiens_hsa030131.66965217
19Oocyte meiosis_Homo sapiens_hsa041141.63604433
20Viral carcinogenesis_Homo sapiens_hsa052031.58669669
21Long-term depression_Homo sapiens_hsa047301.58346602
22Base excision repair_Homo sapiens_hsa034101.55430852
23Cholinergic synapse_Homo sapiens_hsa047251.54546226
24Glioma_Homo sapiens_hsa052141.53799577
25B cell receptor signaling pathway_Homo sapiens_hsa046621.53513323
26Insulin secretion_Homo sapiens_hsa049111.51245597
27Hepatitis B_Homo sapiens_hsa051611.49321634
28Endometrial cancer_Homo sapiens_hsa052131.44278824
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44225111
30Taste transduction_Homo sapiens_hsa047421.43898612
31Oxytocin signaling pathway_Homo sapiens_hsa049211.42797418
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42041300
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39810717
34Serotonergic synapse_Homo sapiens_hsa047261.37898956
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35487021
36Phototransduction_Homo sapiens_hsa047441.34370269
37Type II diabetes mellitus_Homo sapiens_hsa049301.33641125
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30269554
39Salivary secretion_Homo sapiens_hsa049701.30172439
40Non-homologous end-joining_Homo sapiens_hsa034501.29762835
41Circadian rhythm_Homo sapiens_hsa047101.29724114
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27308856
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24133283
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23681826
45ErbB signaling pathway_Homo sapiens_hsa040121.22875876
46HTLV-I infection_Homo sapiens_hsa051661.21863681
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21163727
48Epstein-Barr virus infection_Homo sapiens_hsa051691.20833765
49Small cell lung cancer_Homo sapiens_hsa052221.20541263
50Systemic lupus erythematosus_Homo sapiens_hsa053221.20196788
51Renin secretion_Homo sapiens_hsa049241.19390649
52Measles_Homo sapiens_hsa051621.19309895
53Bladder cancer_Homo sapiens_hsa052191.18624585
54Nucleotide excision repair_Homo sapiens_hsa034201.17417409
55Herpes simplex infection_Homo sapiens_hsa051681.17108985
56mTOR signaling pathway_Homo sapiens_hsa041501.16848823
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16521838
58Axon guidance_Homo sapiens_hsa043601.15173707
59cAMP signaling pathway_Homo sapiens_hsa040241.14798238
60Colorectal cancer_Homo sapiens_hsa052101.14533334
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12800076
62Gastric acid secretion_Homo sapiens_hsa049711.12503248
63Notch signaling pathway_Homo sapiens_hsa043301.12240395
64Gap junction_Homo sapiens_hsa045401.11648762
65GnRH signaling pathway_Homo sapiens_hsa049121.09987541
66Cocaine addiction_Homo sapiens_hsa050301.09803446
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09340762
68NF-kappa B signaling pathway_Homo sapiens_hsa040641.09338868
69Osteoclast differentiation_Homo sapiens_hsa043801.07328903
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07249128
71Ribosome_Homo sapiens_hsa030101.06521100
72Biosynthesis of amino acids_Homo sapiens_hsa012301.05782460
73Estrogen signaling pathway_Homo sapiens_hsa049151.05467837
74Calcium signaling pathway_Homo sapiens_hsa040201.04143512
75Melanogenesis_Homo sapiens_hsa049161.03310872
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02764485
77* mRNA surveillance pathway_Homo sapiens_hsa030151.02739847
78Dilated cardiomyopathy_Homo sapiens_hsa054141.01407374
79Renal cell carcinoma_Homo sapiens_hsa052110.97104809
80Non-small cell lung cancer_Homo sapiens_hsa052230.96150795
81Apoptosis_Homo sapiens_hsa042100.96010940
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95877217
83T cell receptor signaling pathway_Homo sapiens_hsa046600.94886247
84Collecting duct acid secretion_Homo sapiens_hsa049660.94681769
85Hippo signaling pathway_Homo sapiens_hsa043900.94040981
86Cell cycle_Homo sapiens_hsa041100.92963889
87Alcoholism_Homo sapiens_hsa050340.91760202
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88955717
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88120667
90Dorso-ventral axis formation_Homo sapiens_hsa043200.87422300
91Choline metabolism in cancer_Homo sapiens_hsa052310.86781372
92Glucagon signaling pathway_Homo sapiens_hsa049220.86721488
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85471959
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85361293
95Viral myocarditis_Homo sapiens_hsa054160.85284986
96MAPK signaling pathway_Homo sapiens_hsa040100.83781309
97FoxO signaling pathway_Homo sapiens_hsa040680.83026386
98Shigellosis_Homo sapiens_hsa051310.82856882
99Thyroid cancer_Homo sapiens_hsa052160.81941372
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81237802
101Primary immunodeficiency_Homo sapiens_hsa053400.77861341
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.77717802
103Influenza A_Homo sapiens_hsa051640.77428690
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77121922
105Hepatitis C_Homo sapiens_hsa051600.76813036
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74883720
107Pentose phosphate pathway_Homo sapiens_hsa000300.74489833
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.73797427
109Wnt signaling pathway_Homo sapiens_hsa043100.73521028
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72205150
111Adherens junction_Homo sapiens_hsa045200.71977675
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.71238594
113Vibrio cholerae infection_Homo sapiens_hsa051100.69578681
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69213329
115Prion diseases_Homo sapiens_hsa050200.68375264
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66856494
117TGF-beta signaling pathway_Homo sapiens_hsa043500.66783569
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66650421
119Melanoma_Homo sapiens_hsa052180.66535060
120Leishmaniasis_Homo sapiens_hsa051400.66532740
121Pathways in cancer_Homo sapiens_hsa052000.66397059
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.65735095
123Inositol phosphate metabolism_Homo sapiens_hsa005620.64937696
124Pancreatic cancer_Homo sapiens_hsa052120.63344910
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62743620
126Toxoplasmosis_Homo sapiens_hsa051450.62008072
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.61038436
128Carbon metabolism_Homo sapiens_hsa012000.60989041
129Basal cell carcinoma_Homo sapiens_hsa052170.58862465
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58733758
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58430609
132MicroRNAs in cancer_Homo sapiens_hsa052060.57836145
133Chronic myeloid leukemia_Homo sapiens_hsa052200.57834727
134Rap1 signaling pathway_Homo sapiens_hsa040150.57403885
135Thyroid hormone synthesis_Homo sapiens_hsa049180.57399979
136Lysine degradation_Homo sapiens_hsa003100.54691499
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54343052
138Insulin signaling pathway_Homo sapiens_hsa049100.53321227
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53083152
140Prolactin signaling pathway_Homo sapiens_hsa049170.52784645
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52756740
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51672829
143Ras signaling pathway_Homo sapiens_hsa040140.51510383
144Prostate cancer_Homo sapiens_hsa052150.51506023
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50655427
146Tight junction_Homo sapiens_hsa045300.50230845
147HIF-1 signaling pathway_Homo sapiens_hsa040660.49324468
148TNF signaling pathway_Homo sapiens_hsa046680.49131038
149p53 signaling pathway_Homo sapiens_hsa041150.48781335
150Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47124370
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.46850713
152One carbon pool by folate_Homo sapiens_hsa006700.46749225
153Proteoglycans in cancer_Homo sapiens_hsa052050.46689188
154Jak-STAT signaling pathway_Homo sapiens_hsa046300.46340002
155Chemokine signaling pathway_Homo sapiens_hsa040620.45558006
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45355833
157VEGF signaling pathway_Homo sapiens_hsa043700.41707092
158Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40164546
159Focal adhesion_Homo sapiens_hsa045100.39704261

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