CSTF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.16235912
2proteasome assembly (GO:0043248)5.10826716
3establishment of integrated proviral latency (GO:0075713)4.79165317
4sister chromatid segregation (GO:0000819)4.56065843
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.55447770
6mitotic sister chromatid segregation (GO:0000070)4.39103945
7regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.38482446
8anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.33876007
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.28565309
10nuclear pore complex assembly (GO:0051292)4.21690246
11attachment of spindle microtubules to kinetochore (GO:0008608)4.21632303
12ribosome assembly (GO:0042255)4.19498075
13negative regulation of ligase activity (GO:0051352)4.18370356
14negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.18370356
15nuclear pore organization (GO:0006999)4.16301289
16metaphase plate congression (GO:0051310)3.89897933
17establishment of viral latency (GO:0019043)3.89305772
18telomere maintenance via recombination (GO:0000722)3.86318136
19pre-miRNA processing (GO:0031054)3.85947006
20purine nucleobase biosynthetic process (GO:0009113)3.85404262
21cullin deneddylation (GO:0010388)3.79632930
22protein localization to kinetochore (GO:0034501)3.79321183
23positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.77588188
24regulation of cellular amino acid metabolic process (GO:0006521)3.71134820
25DNA ligation (GO:0006266)3.70972677
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.68859639
27DNA replication-dependent nucleosome assembly (GO:0006335)3.67970911
28DNA replication-dependent nucleosome organization (GO:0034723)3.67970911
29DNA replication initiation (GO:0006270)3.67912521
30protein deneddylation (GO:0000338)3.66664636
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.66464862
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.66464862
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.66464862
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66211515
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65320531
36signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65320531
37rRNA modification (GO:0000154)3.61911251
38positive regulation of ligase activity (GO:0051351)3.61288443
39mitotic sister chromatid cohesion (GO:0007064)3.60944713
40signal transduction involved in DNA integrity checkpoint (GO:0072401)3.59413151
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.59413151
42regulation of centriole replication (GO:0046599)3.57178295
43synaptic vesicle maturation (GO:0016188)3.55137894
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.54519756
45regulation of DNA endoreduplication (GO:0032875)3.53875494
46regulation of ubiquitin-protein transferase activity (GO:0051438)3.49646816
47locomotory exploration behavior (GO:0035641)3.49006694
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47943967
49DNA strand elongation involved in DNA replication (GO:0006271)3.43570041
50mitotic chromosome condensation (GO:0007076)3.42172782
51spliceosomal snRNP assembly (GO:0000387)3.42093578
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.40955219
53double-strand break repair via nonhomologous end joining (GO:0006303)3.40403290
54non-recombinational repair (GO:0000726)3.40403290
55regulation of ligase activity (GO:0051340)3.37090087
56regulation of translational termination (GO:0006449)3.35383105
57DNA duplex unwinding (GO:0032508)3.35046883
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34403949
59maturation of 5.8S rRNA (GO:0000460)3.34064578
60pore complex assembly (GO:0046931)3.31971188
61pseudouridine synthesis (GO:0001522)3.31552172
62G1/S transition of mitotic cell cycle (GO:0000082)3.31411665
63cell cycle G1/S phase transition (GO:0044843)3.31411665
64DNA double-strand break processing (GO:0000729)3.31034694
65DNA geometric change (GO:0032392)3.30657380
66formation of translation preinitiation complex (GO:0001731)3.30156622
67peptidyl-lysine dimethylation (GO:0018027)3.30003764
68spindle checkpoint (GO:0031577)3.29612491
69DNA catabolic process, exonucleolytic (GO:0000738)3.27452334
70telomere maintenance via telomere lengthening (GO:0010833)3.24447202
71DNA strand elongation (GO:0022616)3.23696367
72mitotic spindle checkpoint (GO:0071174)3.23551396
73establishment of chromosome localization (GO:0051303)3.23506306
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.22536457
75negative regulation of histone methylation (GO:0031061)3.21669040
76mitotic nuclear envelope disassembly (GO:0007077)3.21198995
77kinetochore organization (GO:0051383)3.21054432
78ribosome biogenesis (GO:0042254)3.19838117
79IMP biosynthetic process (GO:0006188)3.19307378
80membrane disassembly (GO:0030397)3.17770489
81nuclear envelope disassembly (GO:0051081)3.17770489
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16683676
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16683676
84negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16683676
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.16683676
86negative regulation of sister chromatid segregation (GO:0033046)3.16683676
87layer formation in cerebral cortex (GO:0021819)3.16101584
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12222814
89mitochondrial RNA metabolic process (GO:0000959)3.11570545
90protein localization to chromosome, centromeric region (GO:0071459)3.10866992
91establishment of protein localization to mitochondrial membrane (GO:0090151)3.10605642
92rRNA methylation (GO:0031167)3.09107600
93negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06741604
94mitotic spindle assembly checkpoint (GO:0007094)3.06287210
95positive regulation of chromosome segregation (GO:0051984)3.06205420
96regulation of mitochondrial translation (GO:0070129)3.06111519
97base-excision repair (GO:0006284)3.04805482
98transcription-coupled nucleotide-excision repair (GO:0006283)3.03537810
99chaperone-mediated protein transport (GO:0072321)3.03018063
100spindle assembly checkpoint (GO:0071173)3.02075875
101regulation of histone H3-K9 methylation (GO:0051570)3.01534133
102mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00405211
103regulation of sister chromatid cohesion (GO:0007063)2.99422017
104kinetochore assembly (GO:0051382)2.99132051
105spliceosomal tri-snRNP complex assembly (GO:0000244)2.98725242
106rRNA processing (GO:0006364)2.97931070
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97106431
108glutamate secretion (GO:0014047)2.94788309
109translesion synthesis (GO:0019985)2.93014691
110mRNA splice site selection (GO:0006376)2.91460389
111chromatin assembly or disassembly (GO:0006333)2.88440996
112sodium ion export (GO:0071436)2.86820341
113regulation of centrosome cycle (GO:0046605)2.86489080
114chromatin assembly (GO:0031497)2.85464496
115DNA replication-independent nucleosome assembly (GO:0006336)2.85154638
116DNA replication-independent nucleosome organization (GO:0034724)2.85154638
117synaptic vesicle docking involved in exocytosis (GO:0016081)2.83280120
118synaptic vesicle exocytosis (GO:0016079)2.82399934
119negative regulation of microtubule polymerization (GO:0031115)2.81772541
120regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.81656033
121peptidyl-arginine omega-N-methylation (GO:0035247)2.79573043
122positive regulation of mitotic sister chromatid separation (GO:1901970)2.78594347
123positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.78594347
124positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.78594347
125chromatin remodeling at centromere (GO:0031055)2.78105662
126telomere maintenance via semi-conservative replication (GO:0032201)2.77914063
127regulation of chromosome segregation (GO:0051983)2.75275772
128nucleobase biosynthetic process (GO:0046112)2.74601817
129regulation of centrosome duplication (GO:0010824)2.73713317
130DNA conformation change (GO:0071103)2.73704826
131DNA topological change (GO:0006265)2.72614799
132mitotic recombination (GO:0006312)2.71221650
133mitotic spindle organization (GO:0007052)2.70941662
134heterochromatin organization (GO:0070828)2.70569318
135negative regulation of RNA splicing (GO:0033119)2.69516456
136CENP-A containing nucleosome assembly (GO:0034080)2.68445197
137cellular potassium ion homeostasis (GO:0030007)2.67827712
138positive regulation of dendritic spine morphogenesis (GO:0061003)2.67769106
139IMP metabolic process (GO:0046040)2.67628296
140positive regulation of synapse maturation (GO:0090129)2.67475465
141viral mRNA export from host cell nucleus (GO:0046784)2.67069718
142DNA replication checkpoint (GO:0000076)2.66406001
143establishment of mitotic spindle localization (GO:0040001)2.66215310
144protein localization to chromosome (GO:0034502)2.65956808
145dosage compensation (GO:0007549)2.65304171
146folic acid-containing compound biosynthetic process (GO:0009396)2.61742791
147negative regulation of gene expression, epigenetic (GO:0045814)2.61132622
148regulation of synaptic vesicle exocytosis (GO:2000300)2.61050859
149peptidyl-arginine methylation (GO:0018216)2.60502744
150peptidyl-arginine N-methylation (GO:0035246)2.60502744
151histone exchange (GO:0043486)2.59497825
152regulation of glutamate receptor signaling pathway (GO:1900449)2.58069544
153regulation of mitotic metaphase/anaphase transition (GO:0030071)2.54109102
154postreplication repair (GO:0006301)2.54020850
155chromatin silencing (GO:0006342)2.53664141
156neurotransmitter secretion (GO:0007269)2.53544260
157exploration behavior (GO:0035640)2.53282137
158somatic diversification of immune receptors via somatic mutation (GO:0002566)2.53099470
159somatic hypermutation of immunoglobulin genes (GO:0016446)2.53099470
160ATP-dependent chromatin remodeling (GO:0043044)2.52993929
161mitotic metaphase plate congression (GO:0007080)2.52990963
162mRNA transport (GO:0051028)2.52645406
163histone H2A acetylation (GO:0043968)2.52171460
164regulation of spindle organization (GO:0090224)2.51628897
165establishment of mitotic spindle orientation (GO:0000132)2.50924986
166negative regulation of chromosome segregation (GO:0051985)2.50686538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.57536032
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.78715769
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.27990798
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.68888389
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52851909
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30528928
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.14242624
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97990299
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.88329265
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.72466903
11MYC_22102868_ChIP-Seq_BL_Human2.67518506
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65888115
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63253242
14EZH2_22144423_ChIP-Seq_EOC_Human2.51781398
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43087902
16* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41385523
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38099156
18DCP1A_22483619_ChIP-Seq_HELA_Human2.36699169
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.35621378
20VDR_23849224_ChIP-Seq_CD4+_Human2.30495684
21ELK1_19687146_ChIP-ChIP_HELA_Human2.29314633
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25057355
23AR_21909140_ChIP-Seq_LNCAP_Human2.18254116
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16817998
25* GABP_19822575_ChIP-Seq_HepG2_Human2.13086875
26ESR1_15608294_ChIP-ChIP_MCF-7_Human2.08307088
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07242776
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02264517
29E2F7_22180533_ChIP-Seq_HELA_Human11.1462203
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87928805
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87098502
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86973915
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83968001
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.83576700
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.82224259
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79966210
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.78874022
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77641745
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77326517
40CIITA_25753668_ChIP-Seq_RAJI_Human1.73286526
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73022018
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.68670962
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65711102
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64270420
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.57606187
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52145569
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50772512
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47610137
49XRN2_22483619_ChIP-Seq_HELA_Human1.46824135
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45343103
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42988099
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42436143
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42372041
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41759962
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38781776
56* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37769453
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37756707
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37459778
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36378980
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36195470
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31479044
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29937661
63KDM5A_27292631_Chip-Seq_BREAST_Human1.29274350
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.28912205
65MYC_18940864_ChIP-ChIP_HL60_Human1.28233444
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28077855
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26261772
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24801342
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19680202
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19595212
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19439955
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19244076
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17364869
74* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16280668
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15932137
76REST_21632747_ChIP-Seq_MESCs_Mouse1.13906292
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13463610
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12919169
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12072192
80* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10532063
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10056901
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09302137
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08861434
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08729373
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.07202089
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06072639
87KDM2B_26808549_Chip-Seq_DND41_Human1.05902864
88TTF2_22483619_ChIP-Seq_HELA_Human1.04631954
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02714890
90TCF7_22412390_ChIP-Seq_EML_Mouse1.02238053
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02204593
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00889631
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00505871
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.00225391
95KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97827305
96* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97624228
97FOXP3_21729870_ChIP-Seq_TREG_Human0.97358674
98TFEB_21752829_ChIP-Seq_HELA_Human0.97152629
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95708893
100ETS1_20019798_ChIP-Seq_JURKAT_Human0.95605419
101NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95507807
102* SOX17_20123909_ChIP-Seq_XEN_Mouse0.95096620
103NANOG_16153702_ChIP-ChIP_HESCs_Human0.94979828
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93728976
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93301705
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93297964
107NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93269238
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92956213
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92874622
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92737107
111VDR_21846776_ChIP-Seq_THP-1_Human0.92067176
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91702162
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91292218
114DROSHA_22980978_ChIP-Seq_HELA_Human0.91285069
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90117562
116EWS_26573619_Chip-Seq_HEK293_Human0.89044485
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.88648171
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88299649
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87552441
120CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87468380
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86994361
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85459643
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85293002
124* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85158915
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.84829626
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84415542
127ZNF274_21170338_ChIP-Seq_K562_Hela0.83832134
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83795273
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82721343
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81741411
131IRF1_19129219_ChIP-ChIP_H3396_Human0.80754035
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80704295
133RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79890677
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79880570
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.79743647
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.79681351
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.79083712
138EST1_17652178_ChIP-ChIP_JURKAT_Human0.77106264
139ZNF263_19887448_ChIP-Seq_K562_Human0.76118820
140EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.75031430
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.73789012
142RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.73658246
143TP63_19390658_ChIP-ChIP_HaCaT_Human0.72340853
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71201876
145SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70715436
146TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69010566
147SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.67957185
148TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.63817701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.30683961
2MP0010094_abnormal_chromosome_stability3.39339594
3MP0003111_abnormal_nucleus_morphology3.12057936
4MP0009697_abnormal_copulation2.95402459
5MP0003123_paternal_imprinting2.88266303
6MP0008877_abnormal_DNA_methylation2.81251101
7MP0003718_maternal_effect2.81106275
8MP0003635_abnormal_synaptic_transmissio2.66049990
9MP0003787_abnormal_imprinting2.57383134
10MP0005423_abnormal_somatic_nervous2.50211340
11MP0003880_abnormal_central_pattern2.50055587
12MP0003077_abnormal_cell_cycle2.39037225
13MP0003121_genomic_imprinting2.35525907
14MP0004957_abnormal_blastocyst_morpholog2.34920288
15MP0003693_abnormal_embryo_hatching2.22846330
16MP0003806_abnormal_nucleotide_metabolis2.15036486
17MP0008057_abnormal_DNA_replication2.14978554
18MP0002063_abnormal_learning/memory/cond2.03742664
19MP0006035_abnormal_mitochondrial_morpho1.95197019
20MP0009745_abnormal_behavioral_response1.89880473
21MP0004270_analgesia1.87496203
22MP0000569_abnormal_digit_pigmentation1.86606619
23MP0008058_abnormal_DNA_repair1.83436669
24MP0001730_embryonic_growth_arrest1.79378126
25MP0006292_abnormal_olfactory_placode1.78024985
26MP0002064_seizures1.70245892
27MP0008789_abnormal_olfactory_epithelium1.69832740
28MP0009046_muscle_twitch1.69766403
29MP0001968_abnormal_touch/_nociception1.69400851
30MP0002396_abnormal_hematopoietic_system1.65282984
31MP0010030_abnormal_orbit_morphology1.64341134
32MP0000372_irregular_coat_pigmentation1.64056365
33MP0003941_abnormal_skin_development1.61585700
34MP0006036_abnormal_mitochondrial_physio1.59678833
35MP0010307_abnormal_tumor_latency1.58670307
36MP0010352_gastrointestinal_tract_polyps1.57328806
37MP0004233_abnormal_muscle_weight1.56363486
38MP0008007_abnormal_cellular_replicative1.55298200
39MP0004811_abnormal_neuron_physiology1.50953863
40MP0003186_abnormal_redox_activity1.49626266
41MP0000350_abnormal_cell_proliferation1.49281153
42MP0000358_abnormal_cell_content/1.49239296
43MP0003122_maternal_imprinting1.47803249
44MP0002572_abnormal_emotion/affect_behav1.46681366
45MP0003315_abnormal_perineum_morphology1.44258846
46MP0005076_abnormal_cell_differentiation1.41187634
47MP0001293_anophthalmia1.37834848
48MP0004808_abnormal_hematopoietic_stem1.37474217
49MP0002084_abnormal_developmental_patter1.37293593
50MP0003890_abnormal_embryonic-extraembry1.34965836
51MP0001486_abnormal_startle_reflex1.31406116
52MP0002272_abnormal_nervous_system1.30755979
53MP0005380_embryogenesis_phenotype1.30616885
54MP0001672_abnormal_embryogenesis/_devel1.30616885
55MP0001697_abnormal_embryo_size1.28961528
56MP0000537_abnormal_urethra_morphology1.28934754
57MP0003861_abnormal_nervous_system1.28845519
58MP0010234_abnormal_vibrissa_follicle1.27798227
59MP0002102_abnormal_ear_morphology1.27791864
60MP0008932_abnormal_embryonic_tissue1.27392789
61MP0002085_abnormal_embryonic_tissue1.25858895
62MP0002736_abnormal_nociception_after1.24352683
63MP0002734_abnormal_mechanical_nocicepti1.22785346
64MP0002938_white_spotting1.21690619
65MP0004197_abnormal_fetal_growth/weight/1.20561007
66MP0002080_prenatal_lethality1.19958022
67MP0003937_abnormal_limbs/digits/tail_de1.19408278
68MP0003984_embryonic_growth_retardation1.19131514
69MP0008569_lethality_at_weaning1.16805991
70MP0002019_abnormal_tumor_incidence1.16447016
71MP0002796_impaired_skin_barrier1.16188921
72MP0002152_abnormal_brain_morphology1.15504232
73MP0002088_abnormal_embryonic_growth/wei1.14667331
74MP0000778_abnormal_nervous_system1.12982673
75MP0000653_abnormal_sex_gland1.12055923
76MP0002184_abnormal_innervation1.11524359
77MP0005501_abnormal_skin_physiology1.11407251
78MP0001727_abnormal_embryo_implantation1.11302278
79MP0002086_abnormal_extraembryonic_tissu1.11300601
80MP0004885_abnormal_endolymph1.10911346
81MP0002067_abnormal_sensory_capabilities1.10702293
82MP0002557_abnormal_social/conspecific_i1.08868558
83MP0001529_abnormal_vocalization1.07699009
84MP0000955_abnormal_spinal_cord1.07219556
85MP0004858_abnormal_nervous_system1.06793234
86MP0003283_abnormal_digestive_organ1.06634440
87MP0008260_abnormal_autophagy1.06366803
88MP0003879_abnormal_hair_cell1.05344346
89MP0002822_catalepsy1.03970672
90MP0005187_abnormal_penis_morphology1.03170353
91MP0003119_abnormal_digestive_system0.98274280
92MP0005394_taste/olfaction_phenotype0.97020162
93MP0005499_abnormal_olfactory_system0.97020162
94MP0005623_abnormal_meninges_morphology0.96973992
95MP0001853_heart_inflammation0.95109025
96MP0008961_abnormal_basal_metabolism0.94995258
97MP0004924_abnormal_behavior0.93955056
98MP0005386_behavior/neurological_phenoty0.93955056
99MP0001119_abnormal_female_reproductive0.93363177
100MP0005395_other_phenotype0.91746454
101MP0009703_decreased_birth_body0.91543307
102MP0002111_abnormal_tail_morphology0.91509350
103MP0002882_abnormal_neuron_morphology0.89029328
104MP0003567_abnormal_fetal_cardiomyocyte0.88910282
105MP0004147_increased_porphyrin_level0.87660823
106MP0000703_abnormal_thymus_morphology0.87391927
107MP0001440_abnormal_grooming_behavior0.86920066
108MP0001501_abnormal_sleep_pattern0.86680938
109MP0008770_decreased_survivor_rate0.86399922
110MP0009672_abnormal_birth_weight0.86375880
111MP0001348_abnormal_lacrimal_gland0.86284309
112MP0000428_abnormal_craniofacial_morphol0.84271672
113MP0008995_early_reproductive_senescence0.84059318
114MP0002735_abnormal_chemical_nociception0.83720174
115MP0000647_abnormal_sebaceous_gland0.83185778
116MP0002733_abnormal_thermal_nociception0.82763329
117MP0001881_abnormal_mammary_gland0.81010344
118MP0000313_abnormal_cell_death0.80653664
119MP0000631_abnormal_neuroendocrine_gland0.80458383
120MP0002233_abnormal_nose_morphology0.79739498
121MP0002066_abnormal_motor_capabilities/c0.79730856
122MP0005384_cellular_phenotype0.77923783
123MP0002089_abnormal_postnatal_growth/wei0.77571576
124MP0003699_abnormal_female_reproductive0.76432526
125MP0002160_abnormal_reproductive_system0.75598127
126MP0002081_perinatal_lethality0.74892767
127MP0009333_abnormal_splenocyte_physiolog0.73872062
128MP0003698_abnormal_male_reproductive0.73630352
129MP0001929_abnormal_gametogenesis0.73355189
130MP0005389_reproductive_system_phenotype0.72249967
131MP0001970_abnormal_pain_threshold0.71714690
132MP0001177_atelectasis0.71188704
133MP0001346_abnormal_lacrimal_gland0.71134307
134MP0002210_abnormal_sex_determination0.70840473
135MP0003221_abnormal_cardiomyocyte_apopto0.70745808
136MP0002751_abnormal_autonomic_nervous0.70507935
137MP0001286_abnormal_eye_development0.70451650
138MP0002163_abnormal_gland_morphology0.70252966
139MP0001145_abnormal_male_reproductive0.69677259
140MP0001764_abnormal_homeostasis0.69309295
141MP0002161_abnormal_fertility/fecundity0.68976730
142MP0000049_abnormal_middle_ear0.68361922
143MP0000490_abnormal_crypts_of0.68342522
144MP0010769_abnormal_survival0.68245304
145MP0010768_mortality/aging0.67407549
146MP0003786_premature_aging0.67085510
147MP0002697_abnormal_eye_size0.66601642
148MP0000627_abnormal_mammary_gland0.64034195
149MP0002234_abnormal_pharynx_morphology0.63894745
150MP0001661_extended_life_span0.63302729
151MP0002132_abnormal_respiratory_system0.61076443
152MP0005075_abnormal_melanosome_morpholog0.60992961
153MP0003936_abnormal_reproductive_system0.55285805
154MP0005408_hypopigmentation0.54874712
155MP0002092_abnormal_eye_morphology0.54826023
156MP0005621_abnormal_cell_physiology0.51828909
157MP0009053_abnormal_anal_canal0.50637776
158MP0005367_renal/urinary_system_phenotyp0.50175165
159MP0000516_abnormal_urinary_system0.50175165

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.76489193
2Acute encephalopathy (HP:0006846)3.56573609
3Abnormality of the preputium (HP:0100587)3.52157741
4Meckel diverticulum (HP:0002245)3.51686134
5Acute necrotizing encephalopathy (HP:0006965)3.50386368
6Abnormal mitochondria in muscle tissue (HP:0008316)3.47519019
7Increased serum pyruvate (HP:0003542)3.35270205
8Abnormality of glycolysis (HP:0004366)3.33334322
9Abnormality of chromosome stability (HP:0003220)3.32908423
10Abnormality of the ileum (HP:0001549)3.29714838
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.28588096
12Ependymoma (HP:0002888)3.27614888
13Microvesicular hepatic steatosis (HP:0001414)3.17729563
14Increased CSF lactate (HP:0002490)3.16674422
15Abnormality of the lower motor neuron (HP:0002366)3.15469259
16Hepatocellular necrosis (HP:0001404)3.04180510
17Astrocytoma (HP:0009592)3.03538782
18Abnormality of the astrocytes (HP:0100707)3.03538782
19Papilledema (HP:0001085)3.01761712
20Mitochondrial inheritance (HP:0001427)2.95572074
21Volvulus (HP:0002580)2.90710588
22Hepatic necrosis (HP:0002605)2.88611446
23Birth length less than 3rd percentile (HP:0003561)2.86659016
24Abnormality of the labia minora (HP:0012880)2.86418471
25Ankyloglossia (HP:0010296)2.83484130
26Multiple enchondromatosis (HP:0005701)2.81064084
27Increased nuchal translucency (HP:0010880)2.80973284
28Duodenal stenosis (HP:0100867)2.79160914
29Small intestinal stenosis (HP:0012848)2.79160914
30Focal seizures (HP:0007359)2.78203843
31Type I transferrin isoform profile (HP:0003642)2.76076735
32Increased serum lactate (HP:0002151)2.74648603
33Visual hallucinations (HP:0002367)2.74366800
34Focal motor seizures (HP:0011153)2.72518979
35Progressive macrocephaly (HP:0004481)2.72105039
36Glioma (HP:0009733)2.71977948
37Pelvic girdle muscle weakness (HP:0003749)2.70789984
38Shoulder girdle muscle weakness (HP:0003547)2.69389644
39Cerebral edema (HP:0002181)2.67727155
40Pointed chin (HP:0000307)2.62602209
41Insomnia (HP:0100785)2.62100937
42Hyperacusis (HP:0010780)2.60813550
43Horseshoe kidney (HP:0000085)2.58354698
44Abnormal lung lobation (HP:0002101)2.54876793
45Medulloblastoma (HP:0002885)2.52831980
46Impaired smooth pursuit (HP:0007772)2.49486838
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47252804
48Abnormality of alanine metabolism (HP:0010916)2.47252804
49Hyperalaninemia (HP:0003348)2.47252804
50Amyotrophic lateral sclerosis (HP:0007354)2.46258428
51Myokymia (HP:0002411)2.44355152
52Abnormal glycosylation (HP:0012345)2.44061336
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44061336
54Abnormal protein N-linked glycosylation (HP:0012347)2.44061336
55Abnormal protein glycosylation (HP:0012346)2.44061336
56Abnormality of oral frenula (HP:0000190)2.40274950
57Renal duplication (HP:0000075)2.40272936
58Reticulocytopenia (HP:0001896)2.39911773
59Lactic acidosis (HP:0003128)2.38515507
60Increased hepatocellular lipid droplets (HP:0006565)2.37056553
61Aplastic anemia (HP:0001915)2.36707062
62Colon cancer (HP:0003003)2.36646070
63Impaired vibration sensation in the lower limbs (HP:0002166)2.36258251
64Abnormality of the hip-girdle musculature (HP:0001445)2.35011729
65Abnormality of the musculature of the pelvis (HP:0001469)2.35011729
66Abnormality of ocular smooth pursuit (HP:0000617)2.31730521
67Premature ovarian failure (HP:0008209)2.31079396
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30584666
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30584666
70Abnormality of the duodenum (HP:0002246)2.29639127
71Secondary amenorrhea (HP:0000869)2.28530186
72Abnormal gallbladder physiology (HP:0012438)2.26073382
73Cholecystitis (HP:0001082)2.26073382
74Proximal placement of thumb (HP:0009623)2.23046200
75Subacute progressive viral hepatitis (HP:0006572)2.22226060
76Absent radius (HP:0003974)2.22127800
77Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21735821
78Single umbilical artery (HP:0001195)2.21603999
79Abnormality of the fetal cardiovascular system (HP:0010948)2.21603999
80Abnormal umbilical cord blood vessels (HP:0011403)2.21603999
81Exercise intolerance (HP:0003546)2.20218502
82Obsessive-compulsive behavior (HP:0000722)2.19418588
83Truncal ataxia (HP:0002078)2.19330196
84Respiratory difficulties (HP:0002880)2.18890896
85Abnormality of the anterior horn cell (HP:0006802)2.18719819
86Degeneration of anterior horn cells (HP:0002398)2.18719819
87Pancytopenia (HP:0001876)2.17715500
88Ectopic kidney (HP:0000086)2.17709187
89Rough bone trabeculation (HP:0100670)2.16133315
90Poor eye contact (HP:0000817)2.15684298
91Urinary urgency (HP:0000012)2.15308134
92Deviation of the thumb (HP:0009603)2.14882230
93Carpal bone hypoplasia (HP:0001498)2.13756529
94Short 4th metacarpal (HP:0010044)2.10380840
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10380840
96Lipid accumulation in hepatocytes (HP:0006561)2.09402748
97Hemiplegia (HP:0002301)2.08347326
98Epileptic encephalopathy (HP:0200134)2.08136166
99Overriding aorta (HP:0002623)2.08080412
100Reduced antithrombin III activity (HP:0001976)2.07434046
101Aplasia involving forearm bones (HP:0009822)2.07147887
102Absent forearm bone (HP:0003953)2.07147887
103Abnormality of the umbilical cord (HP:0010881)2.06792385
104Choanal atresia (HP:0000453)2.05953796
105Abnormality of the carotid arteries (HP:0005344)2.05725141
106Elfin facies (HP:0004428)2.05577872
107Basal cell carcinoma (HP:0002671)2.05104148
108Myelodysplasia (HP:0002863)2.03194988
109Increased intramyocellular lipid droplets (HP:0012240)2.03068529
110Nephroblastoma (Wilms tumor) (HP:0002667)2.02577593
111Resting tremor (HP:0002322)2.00890934
112Abnormality of chromosome segregation (HP:0002916)2.00867362
113Neoplasm of the oral cavity (HP:0100649)2.00514757
114Testicular atrophy (HP:0000029)2.00356996
115Sloping forehead (HP:0000340)2.00192955
116Absence seizures (HP:0002121)1.99178354
117Embryonal renal neoplasm (HP:0011794)1.98518171
118Acute lymphatic leukemia (HP:0006721)1.97830318
119Clubbing of toes (HP:0100760)1.96941484
120Gaze-evoked nystagmus (HP:0000640)1.96282162
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.96153338
1223-Methylglutaconic aciduria (HP:0003535)1.96001312
123Atonic seizures (HP:0010819)1.95500545
124Triphalangeal thumb (HP:0001199)1.95090301
125Trigonocephaly (HP:0000243)1.93620339
126Sandal gap (HP:0001852)1.93473194
127Urinary bladder sphincter dysfunction (HP:0002839)1.93413192
128Leukodystrophy (HP:0002415)1.93131242
129Combined immunodeficiency (HP:0005387)1.92298939
130Neoplasm of the adrenal gland (HP:0100631)1.91324883
131Missing ribs (HP:0000921)1.91308051
132Absent thumb (HP:0009777)1.90848527
133Bifid tongue (HP:0010297)1.90412801
134Renovascular hypertension (HP:0100817)1.90136721
135Abnormality of methionine metabolism (HP:0010901)1.90131863
136Sparse eyelashes (HP:0000653)1.89331338
137Respiratory failure (HP:0002878)1.88685182
138Ragged-red muscle fibers (HP:0003200)1.88569807
139Progressive muscle weakness (HP:0003323)1.88100651
140Inappropriate behavior (HP:0000719)1.87531104
141Impaired social interactions (HP:0000735)1.86500487
142Abnormal social behavior (HP:0012433)1.86500487
143Oral leukoplakia (HP:0002745)1.86177679
144Febrile seizures (HP:0002373)1.85733998
145Neoplasm of striated muscle (HP:0009728)1.85646330
146Progressive cerebellar ataxia (HP:0002073)1.85619733
147Preaxial hand polydactyly (HP:0001177)1.85041592
148Abnormality of cochlea (HP:0000375)1.82052979
149Chromsome breakage (HP:0040012)1.81944577
150Atrophy/Degeneration involving motor neurons (HP:0007373)1.81922407
151Aqueductal stenosis (HP:0002410)1.79796038
152Ankle clonus (HP:0011448)1.79278244
153Broad palm (HP:0001169)1.78579153
154Annular pancreas (HP:0001734)1.77376479
155Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76734684
156Truncal obesity (HP:0001956)1.75933787
157Bowel diverticulosis (HP:0005222)1.75699246
158Rhabdomyosarcoma (HP:0002859)1.74282114
159Abnormality of the fingertips (HP:0001211)1.74135292
160Malignant gastrointestinal tract tumors (HP:0006749)1.73900254
161Gastrointestinal carcinoma (HP:0002672)1.73900254
162Depression (HP:0000716)1.73537957
163Dialeptic seizures (HP:0011146)1.73465689
164Attention deficit hyperactivity disorder (HP:0007018)1.72543875
165Sacral dimple (HP:0000960)1.72428453
166Cafe-au-lait spot (HP:0000957)1.71928926
167Tetraplegia (HP:0002445)1.71435715
168Neoplasm of the adrenal cortex (HP:0100641)1.70190155
169Dysmetric saccades (HP:0000641)1.69334784
170Apathy (HP:0000741)1.69216214
171Broad thumb (HP:0011304)1.69210448
172Cerebral hypomyelination (HP:0006808)1.65243878
173Dysdiadochokinesis (HP:0002075)1.64497060
174Abnormal number of incisors (HP:0011064)1.64087155
175Diplopia (HP:0000651)1.63766899
176Abnormality of binocular vision (HP:0011514)1.63766899
177Excessive salivation (HP:0003781)1.63399851
178Drooling (HP:0002307)1.63399851
179Increased density of long bones (HP:0006392)1.63082556
180Neoplasm of the heart (HP:0100544)1.62225407
181Macroorchidism (HP:0000053)1.61867137
182Cutis marmorata (HP:0000965)1.61738467
183Intellectual disability, profound (HP:0002187)1.61541761
184Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61005024
185Oligodactyly (hands) (HP:0001180)1.60962933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK17.80494690
2VRK23.89204774
3NEK23.58343864
4CDC73.50066957
5PBK3.38815064
6EEF2K2.92910101
7NME22.79474029
8EIF2AK12.59052245
9EIF2AK32.58729654
10MST42.42063798
11NTRK32.34018444
12ZAK2.23581540
13MAP3K92.21098255
14PDK22.01912863
15SCYL21.97291367
16STK161.92439440
17TSSK61.84413894
18VRK11.80831976
19WEE11.76615894
20TRIM281.75104776
21EPHA41.74346438
22PKN21.68901699
23ALK1.67551158
24MINK11.67500836
25TESK21.62946870
26MARK11.60082258
27NME11.57073868
28KSR11.50281132
29PNCK1.46738926
30MAP3K41.46067057
31SIK21.38941016
32BRSK11.36690957
33CDK121.34279938
34ICK1.32634976
35BUB11.31983399
36NUAK11.30477407
37KSR21.30362943
38DAPK11.25919049
39RPS6KB21.24082025
40NTRK21.23718342
41BCKDK1.23352482
42TTK1.21846502
43EIF2AK21.18601180
44PRKD31.18461739
45PASK1.16575271
46TAF11.16328146
47CAMKK11.15582931
48PLK31.13354254
49PAK61.12575417
50TYRO31.12120134
51MAPKAPK31.09386182
52PAK41.08358195
53MKNK11.08340768
54ATR1.03269287
55CSNK1G31.03077222
56SMG11.02336591
57PLK41.01941724
58TAOK11.00842643
59RAF10.99077144
60KDR0.97166897
61CHEK10.96488221
62PLK10.95931067
63MAP3K100.94807265
64STK100.94619148
65CSNK1G10.92594765
66SRPK10.90911535
67PLK20.87600507
68CCNB10.85165411
69AURKB0.84605550
70TESK10.84316829
71ERBB30.83176059
72MAPK130.80429494
73RPS6KA40.80088138
74CSNK1A1L0.79983026
75WNK30.79539491
76MST1R0.79506771
77CDK150.78718772
78CDK180.77948828
79BCR0.77200357
80CDK20.77175181
81EPHA20.76523495
82DAPK20.75343001
83MARK20.72783794
84BMPR1B0.72093211
85CDK11A0.71029155
86BRD40.70968913
87UHMK10.70165069
88CHEK20.67536431
89CDK140.66450683
90MAP3K80.65454780
91ATM0.64859828
92STK380.64261075
93STK40.63914693
94BRSK20.63759102
95ACVR1B0.63218831
96CDK40.62589297
97CDK10.61622305
98CSNK1G20.61242301
99LIMK10.59892906
100CSNK2A10.58244662
101PRKCI0.58083789
102PRKCG0.56491568
103TNIK0.55979882
104CDK50.55545040
105RPS6KB10.55464999
106AURKA0.55324840
107CDK90.55234829
108MAP4K20.54949786
109CSNK1E0.54929755
110CDK80.54583854
111FGFR10.51876040
112CSNK2A20.51156508
113CDK60.50221778
114PIM20.49881426
115CSNK1D0.48704679
116PRKDC0.47971843
117RET0.47834320
118TLK10.47771786
119ARAF0.44807526
120MTOR0.44660365
121PRKCH0.43393404
122SGK30.42527419
123SIK30.42455992
124STK110.42391614
125CLK10.41702168
126ERBB40.40970436
127LATS20.40919678
128MAPK100.40484998
129TGFBR10.40068597
130MAPK140.39928927
131SGK20.39779672
132PAK10.38616616
133CDK70.38081627
134GSK3B0.37471653
135MELK0.37259834
136FES0.37256508
137MKNK20.37159510
138MAP3K120.36265298
139RPS6KA30.36028420
140FLT30.35707434
141BRAF0.35627604
142RIPK10.35579310
143RPS6KA20.35013956
144CDK190.34878315
145CAMKK20.34281396
146MAP2K70.33987510
147MAPKAPK50.33162282
148PDK10.32752546
149IRAK30.32657847
150DYRK20.31388697
151AKT20.26788979
152STK390.26381880
153RPS6KA50.26284934
154WNK40.24272904
155TAOK20.24157465
156MAP3K50.24032238

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.78254188
2DNA replication_Homo sapiens_hsa030303.03033020
3RNA polymerase_Homo sapiens_hsa030202.58180703
4Mismatch repair_Homo sapiens_hsa034302.57109322
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.30204871
6Nicotine addiction_Homo sapiens_hsa050332.19118240
7Pyrimidine metabolism_Homo sapiens_hsa002402.06318145
8RNA transport_Homo sapiens_hsa030132.03354707
9Long-term potentiation_Homo sapiens_hsa047202.00036948
10Cell cycle_Homo sapiens_hsa041101.96242556
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95455310
12Protein export_Homo sapiens_hsa030601.91361528
13Oocyte meiosis_Homo sapiens_hsa041141.87914141
14Ribosome_Homo sapiens_hsa030101.85130299
15Spliceosome_Homo sapiens_hsa030401.81339355
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74591241
17* mRNA surveillance pathway_Homo sapiens_hsa030151.72846107
18Parkinsons disease_Homo sapiens_hsa050121.72542584
19Oxidative phosphorylation_Homo sapiens_hsa001901.67408851
20Basal transcription factors_Homo sapiens_hsa030221.64660018
21Synaptic vesicle cycle_Homo sapiens_hsa047211.59558124
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.57545056
23Olfactory transduction_Homo sapiens_hsa047401.56670789
24Fatty acid elongation_Homo sapiens_hsa000621.55934639
25Circadian entrainment_Homo sapiens_hsa047131.53548563
26Amphetamine addiction_Homo sapiens_hsa050311.53351460
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49290979
28Glutamatergic synapse_Homo sapiens_hsa047241.48195538
29Base excision repair_Homo sapiens_hsa034101.43977110
30Biosynthesis of amino acids_Homo sapiens_hsa012301.42529235
31GABAergic synapse_Homo sapiens_hsa047271.42396138
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40220901
33Alcoholism_Homo sapiens_hsa050341.39423808
34Pyruvate metabolism_Homo sapiens_hsa006201.38075094
35Dopaminergic synapse_Homo sapiens_hsa047281.37899176
36Morphine addiction_Homo sapiens_hsa050321.37722175
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36809370
38Huntingtons disease_Homo sapiens_hsa050161.34633658
39Purine metabolism_Homo sapiens_hsa002301.33547228
40Carbon metabolism_Homo sapiens_hsa012001.33517043
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32260087
42mTOR signaling pathway_Homo sapiens_hsa041501.30772973
43Homologous recombination_Homo sapiens_hsa034401.28815483
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28541823
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26307262
46Non-homologous end-joining_Homo sapiens_hsa034501.25312960
47Propanoate metabolism_Homo sapiens_hsa006401.25118085
48Glioma_Homo sapiens_hsa052141.23323555
49Steroid biosynthesis_Homo sapiens_hsa001001.22954270
50Colorectal cancer_Homo sapiens_hsa052101.21535308
51Nucleotide excision repair_Homo sapiens_hsa034201.20025491
52One carbon pool by folate_Homo sapiens_hsa006701.18616967
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15080544
54Long-term depression_Homo sapiens_hsa047301.14799890
55Non-small cell lung cancer_Homo sapiens_hsa052231.11689443
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10406839
57Oxytocin signaling pathway_Homo sapiens_hsa049211.08546639
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06979477
59Folate biosynthesis_Homo sapiens_hsa007901.05853812
60Systemic lupus erythematosus_Homo sapiens_hsa053221.03574017
61Gastric acid secretion_Homo sapiens_hsa049711.02550714
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01208604
63Endometrial cancer_Homo sapiens_hsa052131.00930529
64Salivary secretion_Homo sapiens_hsa049701.00522782
65Gap junction_Homo sapiens_hsa045400.99801607
66Cholinergic synapse_Homo sapiens_hsa047250.99703228
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99678211
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99345894
69Estrogen signaling pathway_Homo sapiens_hsa049150.99084003
70RNA degradation_Homo sapiens_hsa030180.98497343
71Fanconi anemia pathway_Homo sapiens_hsa034600.97774854
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97427351
73Selenocompound metabolism_Homo sapiens_hsa004500.97249551
74Glutathione metabolism_Homo sapiens_hsa004800.96949115
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96856037
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95945495
77Insulin secretion_Homo sapiens_hsa049110.90382296
78Vitamin B6 metabolism_Homo sapiens_hsa007500.90021961
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.89576313
80GnRH signaling pathway_Homo sapiens_hsa049120.88052850
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87589191
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86412388
83Cocaine addiction_Homo sapiens_hsa050300.85058860
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84786923
85MicroRNAs in cancer_Homo sapiens_hsa052060.83471904
86Chronic myeloid leukemia_Homo sapiens_hsa052200.83141196
87Alzheimers disease_Homo sapiens_hsa050100.82973910
88Pentose phosphate pathway_Homo sapiens_hsa000300.82304270
89Viral carcinogenesis_Homo sapiens_hsa052030.82224090
90Sulfur relay system_Homo sapiens_hsa041220.82170674
91ErbB signaling pathway_Homo sapiens_hsa040120.81947888
92Type II diabetes mellitus_Homo sapiens_hsa049300.79567966
93Taste transduction_Homo sapiens_hsa047420.77664311
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.77241917
95Thyroid cancer_Homo sapiens_hsa052160.76723406
96Dorso-ventral axis formation_Homo sapiens_hsa043200.75492608
97Melanogenesis_Homo sapiens_hsa049160.75192219
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75026600
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74309303
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73310720
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72161863
102Renin secretion_Homo sapiens_hsa049240.72004715
103VEGF signaling pathway_Homo sapiens_hsa043700.71938926
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71457211
105HTLV-I infection_Homo sapiens_hsa051660.70387231
106Choline metabolism in cancer_Homo sapiens_hsa052310.70250105
107Wnt signaling pathway_Homo sapiens_hsa043100.70176895
108cAMP signaling pathway_Homo sapiens_hsa040240.69877439
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68431223
110Calcium signaling pathway_Homo sapiens_hsa040200.68276859
111N-Glycan biosynthesis_Homo sapiens_hsa005100.67846497
112Hippo signaling pathway_Homo sapiens_hsa043900.67261394
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66919071
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65782117
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65616009
116MAPK signaling pathway_Homo sapiens_hsa040100.65521929
117p53 signaling pathway_Homo sapiens_hsa041150.65491233
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.65004795
119Serotonergic synapse_Homo sapiens_hsa047260.64770052
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63240494
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60230327
122Thyroid hormone synthesis_Homo sapiens_hsa049180.59669110
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59228270
124Metabolic pathways_Homo sapiens_hsa011000.58614496
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57897583
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57738368
127Renal cell carcinoma_Homo sapiens_hsa052110.57439355
128HIF-1 signaling pathway_Homo sapiens_hsa040660.56574136
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56398897
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56115723
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55654030
132Type I diabetes mellitus_Homo sapiens_hsa049400.55612669
133Inositol phosphate metabolism_Homo sapiens_hsa005620.54948248
134Pancreatic cancer_Homo sapiens_hsa052120.54554862
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54432397
136Hedgehog signaling pathway_Homo sapiens_hsa043400.53905405
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53186440
138Epstein-Barr virus infection_Homo sapiens_hsa051690.52328488
139T cell receptor signaling pathway_Homo sapiens_hsa046600.52281890
140Fructose and mannose metabolism_Homo sapiens_hsa000510.51553696
141Axon guidance_Homo sapiens_hsa043600.49581692
142Glucagon signaling pathway_Homo sapiens_hsa049220.49549764
143Sulfur metabolism_Homo sapiens_hsa009200.49201545
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48481820
145Insulin signaling pathway_Homo sapiens_hsa049100.48253239
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47491686
147Fatty acid metabolism_Homo sapiens_hsa012120.47035737
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.44558169
149Primary immunodeficiency_Homo sapiens_hsa053400.42851366
150Galactose metabolism_Homo sapiens_hsa000520.41823629
151Peroxisome_Homo sapiens_hsa041460.39799457
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38369942
153Arginine and proline metabolism_Homo sapiens_hsa003300.36243211
154Butanoate metabolism_Homo sapiens_hsa006500.35836369
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28306669
156Cyanoamino acid metabolism_Homo sapiens_hsa004600.26530565
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24220969
158Shigellosis_Homo sapiens_hsa051310.23211971
159beta-Alanine metabolism_Homo sapiens_hsa004100.22926418
160Regulation of autophagy_Homo sapiens_hsa041400.22307997
161Herpes simplex infection_Homo sapiens_hsa051680.20673803
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18904102
163Lysine degradation_Homo sapiens_hsa003100.18213649
164Caffeine metabolism_Homo sapiens_hsa002320.17817266
165Phenylalanine metabolism_Homo sapiens_hsa003600.15673214
166TGF-beta signaling pathway_Homo sapiens_hsa043500.14046134
167Apoptosis_Homo sapiens_hsa042100.12888874
168Fatty acid degradation_Homo sapiens_hsa000710.07597269
169Tyrosine metabolism_Homo sapiens_hsa003500.04318613
170Cardiac muscle contraction_Homo sapiens_hsa042600.04294944
171Basal cell carcinoma_Homo sapiens_hsa052170.04202724
172Vibrio cholerae infection_Homo sapiens_hsa051100.03668958
173Adherens junction_Homo sapiens_hsa045200.03451475

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »