CST3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)6.34255172
2positive regulation of cellular amide metabolic process (GO:0034250)5.36850300
3chondroitin sulfate catabolic process (GO:0030207)4.82173324
4alanine transport (GO:0032328)4.43939295
5L-amino acid import (GO:0043092)4.21674818
6regulation of interferon-beta biosynthetic process (GO:0045357)4.13329847
7amino acid import (GO:0043090)4.06457160
8positive regulation of monocyte chemotaxis (GO:0090026)4.03924165
9positive regulation of chemokine secretion (GO:0090197)4.03096946
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97980045
11barbed-end actin filament capping (GO:0051016)3.93910577
12regulation of beta-amyloid formation (GO:1902003)3.85596695
13macrophage activation involved in immune response (GO:0002281)3.80322992
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78482551
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.78482551
16modulation by symbiont of host immune response (GO:0052553)3.78482551
17positive regulation by symbiont of host defense response (GO:0052509)3.78482551
18modulation by symbiont of host defense response (GO:0052031)3.78482551
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78482551
20low-density lipoprotein particle remodeling (GO:0034374)3.77991596
21regulation of activation of Janus kinase activity (GO:0010533)3.77010303
22G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.74797488
23positive regulation of antigen processing and presentation (GO:0002579)3.71676619
24negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.66486917
25immunoglobulin mediated immune response (GO:0016064)3.66005106
26L-serine transport (GO:0015825)3.64737594
27response to peptidoglycan (GO:0032494)3.64086573
28oligosaccharide catabolic process (GO:0009313)3.59600875
29serine transport (GO:0032329)3.58277281
30macrophage activation (GO:0042116)3.52147761
31T-helper 1 type immune response (GO:0042088)3.50798332
32cellular potassium ion homeostasis (GO:0030007)3.48402104
33response to cholesterol (GO:0070723)3.47141080
34G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.37957932
35glycosphingolipid catabolic process (GO:0046479)3.37910767
36positive regulation of interferon-alpha production (GO:0032727)3.34811771
37positive regulation of mast cell degranulation (GO:0043306)3.33654290
38positive regulation of mast cell activation involved in immune response (GO:0033008)3.33654290
39virion attachment to host cell (GO:0019062)3.33398972
40adhesion of symbiont to host cell (GO:0044650)3.33398972
41cellular response to cholesterol (GO:0071397)3.32588924
42adenosine receptor signaling pathway (GO:0001973)3.29661375
43cellular response to thyroid hormone stimulus (GO:0097067)3.28517655
44amino sugar catabolic process (GO:0046348)3.28328482
45regulation of monocyte chemotaxis (GO:0090025)3.27696870
46response to auditory stimulus (GO:0010996)3.26439017
47sodium ion export (GO:0071436)3.22731126
48regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.21865122
49negative regulation of interleukin-12 production (GO:0032695)3.16138999
50regulation of interferon-alpha production (GO:0032647)3.11356075
51regulation of antigen processing and presentation (GO:0002577)3.07825602
52negative regulation of interleukin-17 production (GO:0032700)3.07592928
53positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.06923713
54glycolipid catabolic process (GO:0019377)3.05090929
55positive regulation of leukocyte degranulation (GO:0043302)3.02932831
56interferon-gamma-mediated signaling pathway (GO:0060333)3.02335467
57regulation of amyloid precursor protein catabolic process (GO:1902991)3.02267896
58regulation of mast cell degranulation (GO:0043304)3.02018709
59response to sterol (GO:0036314)3.00555538
60mature B cell differentiation involved in immune response (GO:0002313)3.00156372
61adhesion of symbiont to host (GO:0044406)2.99840337
62phagocytosis, engulfment (GO:0006911)2.98644522
63regulation of dendritic cell antigen processing and presentation (GO:0002604)2.97797373
64regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.94826612
65C4-dicarboxylate transport (GO:0015740)2.93520908
66regulation of chemokine secretion (GO:0090196)2.93413747
67purinergic nucleotide receptor signaling pathway (GO:0035590)2.92958612
68negative regulation of granulocyte differentiation (GO:0030853)2.92546527
69positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.91125596
70purinergic receptor signaling pathway (GO:0035587)2.90160427
71positive regulation of mast cell activation (GO:0033005)2.89959236
72regulation of mononuclear cell migration (GO:0071675)2.89294065
73positive regulation of interleukin-12 production (GO:0032735)2.85667279
74regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85165580
75regulation of leukocyte degranulation (GO:0043300)2.83249957
76ceramide catabolic process (GO:0046514)2.80988565
77regulation of cellular amide metabolic process (GO:0034248)2.79661286
78positive regulation of astrocyte differentiation (GO:0048711)2.77639516
79pinocytosis (GO:0006907)2.77388424
80protein localization to endosome (GO:0036010)2.76478732
81regulation of phospholipid biosynthetic process (GO:0071071)2.75430030
82negative regulation of astrocyte differentiation (GO:0048712)2.74508691
83regulation of mast cell activation involved in immune response (GO:0033006)2.71259170
84regulation of T-helper 1 cell differentiation (GO:0045625)2.69931288
85negative regulation of nitric oxide biosynthetic process (GO:0045019)2.69818627
86cellular response to exogenous dsRNA (GO:0071360)2.68866190
87glial cell proliferation (GO:0014009)2.68691139
88cellular response to sterol (GO:0036315)2.68350736
89response to thyroid hormone (GO:0097066)2.67480297
90ruffle organization (GO:0031529)2.66999882
91macrophage chemotaxis (GO:0048246)2.66693153
92cell communication by electrical coupling (GO:0010644)2.66502275
93keratan sulfate catabolic process (GO:0042340)2.60696457
94regulation of superoxide anion generation (GO:0032928)2.57659823
95regulation of T-helper 2 cell differentiation (GO:0045628)2.56560767
96negative regulation of erythrocyte differentiation (GO:0045647)2.56538638
97potassium ion import (GO:0010107)2.56287591
98nucleoside diphosphate catabolic process (GO:0009134)2.55646808
99low-density lipoprotein particle clearance (GO:0034383)2.55369593
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.55015133
101negative regulation of myeloid cell apoptotic process (GO:0033033)2.54918941
102eosinophil chemotaxis (GO:0048245)2.54840084
103sphingolipid catabolic process (GO:0030149)2.53230395
104regulation of astrocyte differentiation (GO:0048710)2.51079734
105angiotensin maturation (GO:0002003)2.51065003
106detection of molecule of bacterial origin (GO:0032490)2.49979391
107positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.49909589
108response to host immune response (GO:0052572)2.49388603
109response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49388603
110regulation of B cell receptor signaling pathway (GO:0050855)2.49082394
111detection of other organism (GO:0098543)2.48756196
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.48399163
113antigen processing and presentation of endogenous antigen (GO:0019883)2.48244643
114regulation of cholesterol storage (GO:0010885)2.48035747
115neutrophil activation involved in immune response (GO:0002283)2.47553377
116cyclooxygenase pathway (GO:0019371)2.46131729
117negative regulation of cytokine production involved in immune response (GO:0002719)2.44582903
118phagosome maturation (GO:0090382)2.44563862
119I-kappaB phosphorylation (GO:0007252)2.43718931
120detection of bacterium (GO:0016045)2.43557898
121regulation of interleukin-17 production (GO:0032660)2.42914842
122dermatan sulfate biosynthetic process (GO:0030208)2.42638210
123regulation of macrophage chemotaxis (GO:0010758)2.42312785
124lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42120385
125cellular response to interferon-gamma (GO:0071346)2.41948762
126detection of external biotic stimulus (GO:0098581)2.41168052
127dermatan sulfate metabolic process (GO:0030205)2.40676627
128positive regulation of lipoprotein lipase activity (GO:0051006)2.39592969
129positive regulation of triglyceride lipase activity (GO:0061365)2.39592969
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.39556969
131response to host (GO:0075136)2.39556969
132response to host defenses (GO:0052200)2.39556969
133granulocyte activation (GO:0036230)2.39153582
134cellular response to interferon-beta (GO:0035458)2.38818566
135natural killer cell differentiation (GO:0001779)2.38087328
136regulation of membrane protein ectodomain proteolysis (GO:0051043)2.37849995
137neurotransmitter uptake (GO:0001504)2.36799035
138cellular sodium ion homeostasis (GO:0006883)2.36706558
139regulation of regulated secretory pathway (GO:1903305)2.36521109
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.35864551
141myeloid dendritic cell differentiation (GO:0043011)2.35554740
142regulation of heat generation (GO:0031650)2.35260243
143positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.34994095
144positive regulation of type 2 immune response (GO:0002830)2.33443263
145membrane lipid catabolic process (GO:0046466)2.33213869
146regulation of cytokine secretion involved in immune response (GO:0002739)2.33176538
147myeloid dendritic cell activation (GO:0001773)2.32679798
148negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.32658134
149regulation of cholesterol esterification (GO:0010872)2.32657861
150positive regulation of chemokine biosynthetic process (GO:0045080)2.32455224
151B cell mediated immunity (GO:0019724)2.32171360
152negative regulation of adenylate cyclase activity (GO:0007194)2.31834842
153macrophage differentiation (GO:0030225)2.30701541
154positive regulation of neurotransmitter secretion (GO:0001956)2.30326367
155myeloid cell activation involved in immune response (GO:0002275)2.30020178
156NIK/NF-kappaB signaling (GO:0038061)2.29872749
157response to interferon-gamma (GO:0034341)2.29786560
158negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.29507802
159negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.28749634
160response to acidic pH (GO:0010447)2.28658067
161modulation by symbiont of host cellular process (GO:0044068)2.26838981
162response to muramyl dipeptide (GO:0032495)2.24675087
163negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.24420873
164actin filament polymerization (GO:0030041)2.24064357
165positive regulation of macrophage cytokine production (GO:0060907)2.22892923
166lipoxygenase pathway (GO:0019372)2.21787243
167positive regulation of extracellular matrix organization (GO:1903055)2.21717499
168peptide catabolic process (GO:0043171)2.21668289
169regulation of podosome assembly (GO:0071801)2.21549219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse3.92025721
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.09211503
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.89012118
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79675302
5* IRF8_27001747_Chip-Seq_BMDM_Mouse2.79568665
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.70679479
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.42582981
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40631755
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23930210
10VDR_21846776_ChIP-Seq_THP-1_Human2.18843746
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11752661
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06442670
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06018395
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04965910
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02433928
16VDR_24763502_ChIP-Seq_THP-1_Human1.99601227
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97861787
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96982473
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93987409
20* ELK3_25401928_ChIP-Seq_HUVEC_Human1.92235112
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92082813
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91756025
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86223462
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84653762
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.82017290
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77824710
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.77765512
28AR_21572438_ChIP-Seq_LNCaP_Human1.76060413
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74561938
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73549162
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72253084
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71732423
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71380456
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68308468
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67467922
36DROSHA_22980978_ChIP-Seq_HELA_Human1.65514614
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60622064
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60481376
39* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60106377
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59652614
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59611193
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58668510
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58668510
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56304944
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54969507
46RUNX_20019798_ChIP-Seq_JUKART_Human1.51227031
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46247235
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.44263049
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.42882354
50RACK7_27058665_Chip-Seq_MCF-7_Human1.40846067
51BCL6_27268052_Chip-Seq_Bcells_Human1.40257724
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39811373
53BCOR_27268052_Chip-Seq_Bcells_Human1.39344233
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39049809
55* VDR_24787735_ChIP-Seq_THP-1_Human1.39005958
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37911457
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.37730203
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35590961
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.34449692
60SPI1_23127762_ChIP-Seq_K562_Human1.34240231
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33738576
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33174037
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32841458
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31294776
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30063884
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28912876
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.28466588
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.28434513
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28210493
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27687170
71KDM2B_26808549_Chip-Seq_DND41_Human1.27367714
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26217072
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25543610
74P68_20966046_ChIP-Seq_HELA_Human1.25246070
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24421862
76* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23587631
77KDM2B_26808549_Chip-Seq_K562_Human1.22803046
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22601482
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.21952462
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.21398286
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21261669
82CLOCK_20551151_ChIP-Seq_293T_Human1.21169067
83TCF7_22412390_ChIP-Seq_EML_Mouse1.18899802
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18223332
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17708469
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16721472
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.16350299
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15849008
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15550504
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.14704097
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14237700
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.13587499
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11654625
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11375536
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10966641
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10929465
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.10711102
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10440508
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10426191
100* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10042278
101GBX2_23144817_ChIP-Seq_PC3_Human1.09699087
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08620621
103SPI1_23547873_ChIP-Seq_NB4_Human1.08592594
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08146847
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05822162
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05460911
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05019254
108STAT1_20625510_ChIP-Seq_HELA_Human1.04953792
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04577189
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04404113
111REST_21632747_ChIP-Seq_MESCs_Mouse1.04310904
112SMC4_20622854_ChIP-Seq_HELA_Human1.03891680
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03059929
114TP53_18474530_ChIP-ChIP_U2OS_Human1.02288687
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02068032
116* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01738631
117SA1_27219007_Chip-Seq_Bcells_Human1.01545824
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01353470
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01353470
120EZH2_22144423_ChIP-Seq_EOC_Human1.01175180
121MAF_26560356_Chip-Seq_TH1_Human1.00498787
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00370870
123SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00115302
124SCL_19346495_ChIP-Seq_HPC-7_Human1.00026334
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97872412
126CTCF_20526341_ChIP-Seq_ESCs_Human0.95632750
127ZNF263_19887448_ChIP-Seq_K562_Human0.93913765
128* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93231689
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90985046
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90369326
131BCAT_22108803_ChIP-Seq_LS180_Human0.85722529
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84493733
133P300_19829295_ChIP-Seq_ESCs_Human0.84342341
134AR_25329375_ChIP-Seq_VCAP_Human0.81909193
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.81361307
136RXR_22108803_ChIP-Seq_LS180_Human0.80325489
137LXR_22292898_ChIP-Seq_THP-1_Human0.80131674
138STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77618195
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76065941
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76043057
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.75803699
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.75414916
143TP63_17297297_ChIP-ChIP_HaCaT_Human0.75334141
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75047430
145EGR1_19032775_ChIP-ChIP_M12_Human0.74688291
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74650692
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.74479763
148* CJUN_26792858_Chip-Seq_BT549_Human0.74039883
149TP53_20018659_ChIP-ChIP_R1E_Mouse0.72888974
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.72284040
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.71984348
152KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71628309
153EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.71521354
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.71456664
155E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.70962367
156REST_18959480_ChIP-ChIP_MESCs_Mouse0.70734104
157CBX2_27304074_Chip-Seq_ESCs_Mouse0.69804638
158ERG_21242973_ChIP-ChIP_JURKAT_Human0.69490547
159DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69045455
160SMAD4_21799915_ChIP-Seq_A2780_Human0.68926848
161* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.68909520
162PU_27001747_Chip-Seq_BMDM_Mouse0.68457286
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.68278774
164CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68195771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.20708910
2MP0003690_abnormal_glial_cell3.74411258
3MP0002254_reproductive_system_inflammat3.36441179
4MP0006082_CNS_inflammation3.18504747
5MP0005058_abnormal_lysosome_morphology3.11920458
6MP0009840_abnormal_foam_cell2.85687720
7MP0002148_abnormal_hypersensitivity_rea2.69299483
8MP0003172_abnormal_lysosome_physiology2.56992889
9MP0004858_abnormal_nervous_system2.53572122
10MP0003191_abnormal_cellular_cholesterol2.46117452
11MP0005671_abnormal_response_to2.45446553
12MP0001853_heart_inflammation2.36940669
13* MP0003075_altered_response_to2.33495090
14MP0003183_abnormal_peptide_metabolism2.29614374
15MP0000685_abnormal_immune_system2.26305367
16MP0005379_endocrine/exocrine_gland_phen2.18465227
17MP0002139_abnormal_hepatobiliary_system2.15350636
18MP0003279_aneurysm2.13804058
19MP0002090_abnormal_vision2.12395500
20MP0002419_abnormal_innate_immunity2.03733292
21MP0001790_abnormal_immune_system1.86671830
22MP0005387_immune_system_phenotype1.86671830
23MP0003136_yellow_coat_color1.80707104
24MP0004510_myositis1.76287237
25MP0005167_abnormal_blood-brain_barrier1.74343980
26MP0005000_abnormal_immune_tolerance1.72774398
27MP0005310_abnormal_salivary_gland1.70874516
28MP0003806_abnormal_nucleotide_metabolis1.70141515
29MP0002163_abnormal_gland_morphology1.68895139
30MP0003329_amyloid_beta_deposits1.67735342
31MP0002638_abnormal_pupillary_reflex1.56643268
32MP0002452_abnormal_antigen_presenting1.55715262
33MP0009384_cardiac_valve_regurgitation1.55212434
34MP0000604_amyloidosis1.54008987
35MP0008260_abnormal_autophagy1.53726248
36MP0009278_abnormal_bone_marrow1.53724409
37MP0001348_abnormal_lacrimal_gland1.53380541
38MP0003436_decreased_susceptibility_to1.52361958
39MP0003634_abnormal_glial_cell1.52178072
40MP0005464_abnormal_platelet_physiology1.50783125
41MP0003633_abnormal_nervous_system1.49715872
42MP0001502_abnormal_circadian_rhythm1.48601388
43MP0004859_abnormal_synaptic_plasticity1.39205865
44MP0005646_abnormal_pituitary_gland1.37535437
45MP0003303_peritoneal_inflammation1.36721587
46MP0005423_abnormal_somatic_nervous1.35575875
47MP0008004_abnormal_stomach_pH1.35495300
48MP0005025_abnormal_response_to1.35007434
49MP0002723_abnormal_immune_serum1.33767505
50MP0003879_abnormal_hair_cell1.33455822
51MP0005171_absent_coat_pigmentation1.32893710
52MP0002064_seizures1.30983633
53MP0010155_abnormal_intestine_physiology1.30969703
54MP0005397_hematopoietic_system_phenotyp1.30261410
55MP0001545_abnormal_hematopoietic_system1.30261410
56MP0000343_altered_response_to1.29860829
57MP0001819_abnormal_immune_cell1.25388893
58MP0005365_abnormal_bile_salt1.25262346
59MP0001800_abnormal_humoral_immune1.24307661
60MP0003453_abnormal_keratinocyte_physiol1.23641425
61MP0009785_altered_susceptibility_to1.22871102
62MP0002420_abnormal_adaptive_immunity1.18939626
63MP0001533_abnormal_skeleton_physiology1.17716025
64MP0004947_skin_inflammation1.17168196
65MP0001486_abnormal_startle_reflex1.16347534
66MP0003011_delayed_dark_adaptation1.14340439
67MP0009764_decreased_sensitivity_to1.12772444
68MP0002998_abnormal_bone_remodeling1.12697758
69MP0001346_abnormal_lacrimal_gland1.11406850
70MP0006054_spinal_hemorrhage1.09667927
71MP0001501_abnormal_sleep_pattern1.08769184
72MP0004883_abnormal_blood_vessel1.08717659
73MP0003635_abnormal_synaptic_transmissio1.08573609
74MP0005451_abnormal_body_composition1.08229483
75MP0003631_nervous_system_phenotype1.08210314
76MP0009046_muscle_twitch1.06887473
77MP0005645_abnormal_hypothalamus_physiol1.04705021
78MP0000920_abnormal_myelination1.02917426
79MP0003448_altered_tumor_morphology1.02431567
80* MP0000858_altered_metastatic_potential1.01788615
81* MP0005166_decreased_susceptibility_to1.00743470
82MP0004885_abnormal_endolymph0.98500716
83MP0005670_abnormal_white_adipose0.97948762
84MP0008874_decreased_physiological_sensi0.97604579
85MP0003045_fibrosis0.97008213
86MP0002736_abnormal_nociception_after0.96093229
87MP0005257_abnormal_intraocular_pressure0.95423842
88MP0008469_abnormal_protein_level0.93460562
89MP0003724_increased_susceptibility_to0.92846750
90MP0005390_skeleton_phenotype0.92709144
91MP0002332_abnormal_exercise_endurance0.91158232
92MP0003828_pulmonary_edema0.90151463
93MP0005360_urolithiasis0.90083154
94MP0009745_abnormal_behavioral_response0.86456810
95MP0003300_gastrointestinal_ulcer0.85692180
96MP0004270_analgesia0.84659611
97MP0001845_abnormal_inflammatory_respons0.84191230
98MP0002166_altered_tumor_susceptibility0.83806780
99MP0002138_abnormal_hepatobiliary_system0.83412485
100MP0002909_abnormal_adrenal_gland0.83331298
101MP0002572_abnormal_emotion/affect_behav0.83258822
102MP0003638_abnormal_response/metabolism_0.81674941
103MP0005595_abnormal_vascular_smooth0.81663050
104MP0001542_abnormal_bone_strength0.80808181
105MP0008569_lethality_at_weaning0.80469228
106MP0002928_abnormal_bile_duct0.79994497
107MP0001968_abnormal_touch/_nociception0.77174882
108MP0001663_abnormal_digestive_system0.76514370
109MP0000465_gastrointestinal_hemorrhage0.76433176
110MP0005164_abnormal_response_to0.76409054
111MP0000249_abnormal_blood_vessel0.75480989
112MP0004019_abnormal_vitamin_homeostasis0.75090488
113MP0009333_abnormal_splenocyte_physiolog0.73942742
114MP0000767_abnormal_smooth_muscle0.73923201
115MP0001958_emphysema0.73494532
116MP0005666_abnormal_adipose_tissue0.72887392
117MP0003091_abnormal_cell_migration0.72568622
118* MP0005165_increased_susceptibility_to0.72267900
119MP0005023_abnormal_wound_healing0.72252414
120MP0002933_joint_inflammation0.72144528
121MP0003632_abnormal_nervous_system0.71914215
122MP0002063_abnormal_learning/memory/cond0.71877702
123MP0005377_hearing/vestibular/ear_phenot0.71129300
124MP0003878_abnormal_ear_physiology0.71129300
125MP0005535_abnormal_body_temperature0.70915037
126MP0001984_abnormal_olfaction0.70026153
127MP0009763_increased_sensitivity_to0.69979276
128MP0002006_tumorigenesis0.69698911
129MP0002733_abnormal_thermal_nociception0.69041064
130MP0000716_abnormal_immune_system0.68958465
131MP0005584_abnormal_enzyme/coenzyme_acti0.68766250
132MP0002405_respiratory_system_inflammati0.68655116
133MP0002118_abnormal_lipid_homeostasis0.66813417
134MP0001851_eye_inflammation0.65459735
135MP0003795_abnormal_bone_structure0.65316449
136MP0003186_abnormal_redox_activity0.63325051
137MP0003866_abnormal_defecation0.63064197

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.13069517
2Abnormality of glycolipid metabolism (HP:0010969)6.03978218
3Abnormality of liposaccharide metabolism (HP:0010968)6.03978218
4Abnormality of glycosphingolipid metabolism (HP:0004343)6.03978218
5Glomerulonephritis (HP:0000099)5.45445278
6Increased neuronal autofluorescent lipopigment (HP:0002074)5.41110234
7Increased cerebral lipofuscin (HP:0011813)5.39786586
8Neurofibrillary tangles (HP:0002185)4.51050369
9Megalencephaly (HP:0001355)4.46233990
10Retinal atrophy (HP:0001105)4.04851539
11Complement deficiency (HP:0004431)3.93987850
12Dysostosis multiplex (HP:0000943)3.89986229
13Aplasia involving bones of the extremities (HP:0009825)3.69466328
14Aplasia involving bones of the upper limbs (HP:0009823)3.69466328
15Aplasia of the phalanges of the hand (HP:0009802)3.69466328
16Abnormality of binocular vision (HP:0011514)3.68373838
17Diplopia (HP:0000651)3.68373838
18Arterial tortuosity (HP:0005116)3.68099866
19Clumsiness (HP:0002312)3.51517328
20Vascular tortuosity (HP:0004948)3.50580855
21Recurrent abscess formation (HP:0002722)3.50550186
22Recurrent bacterial skin infections (HP:0005406)3.48581158
23Basal ganglia calcification (HP:0002135)3.39646339
24Nuclear cataract (HP:0100018)3.35239911
25Purpura (HP:0000979)3.34096091
26Progressive neurologic deterioration (HP:0002344)3.29985963
27Urinary glycosaminoglycan excretion (HP:0003541)3.21611510
28Mucopolysacchariduria (HP:0008155)3.21611510
29Hemiparesis (HP:0001269)3.18276342
30Axonal loss (HP:0003447)3.13001183
31Cerebral inclusion bodies (HP:0100314)3.09554239
32Abnormality of complement system (HP:0005339)3.09539363
33Hemiplegia (HP:0002301)3.09302220
34Vacuolated lymphocytes (HP:0001922)3.07253704
35Tetraparesis (HP:0002273)2.99840234
36Eczematoid dermatitis (HP:0000976)2.98009595
37Abnormality of polysaccharide metabolism (HP:0011012)2.95137590
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95137590
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95137590
40Increased IgM level (HP:0003496)2.92250823
41Vertebral compression fractures (HP:0002953)2.90870172
42Nephritis (HP:0000123)2.90718293
43Abnormality of secondary sexual hair (HP:0009888)2.88300433
44Abnormality of the axillary hair (HP:0100134)2.88300433
45Mutism (HP:0002300)2.86114693
46* Amyloidosis (HP:0011034)2.79949016
47Loss of speech (HP:0002371)2.70963911
48Split foot (HP:0001839)2.69920070
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.62261989
50Prolonged neonatal jaundice (HP:0006579)2.61911839
51Cerebral aneurysm (HP:0004944)2.53830169
52Supranuclear gaze palsy (HP:0000605)2.52314266
53Petechiae (HP:0000967)2.48150667
54Progressive visual loss (HP:0000529)2.44316783
55Upper motor neuron abnormality (HP:0002127)2.44155042
56Chronic otitis media (HP:0000389)2.43163983
57* Dementia (HP:0000726)2.42048691
58Abnormality of macrophages (HP:0004311)2.41058349
59Obstructive lung disease (HP:0006536)2.35407609
60Chronic obstructive pulmonary disease (HP:0006510)2.35407609
61Personality changes (HP:0000751)2.33388359
62Myositis (HP:0100614)2.31383037
63Distal lower limb muscle weakness (HP:0009053)2.23686825
64Neuronal loss in central nervous system (HP:0002529)2.22019698
65Elevated erythrocyte sedimentation rate (HP:0003565)2.21045683
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19078076
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.18442603
68Increased serum ferritin (HP:0003281)2.18068789
69Partial duplication of thumb phalanx (HP:0009944)2.10933794
70Pathologic fracture (HP:0002756)2.10225743
71Hypergammaglobulinemia (HP:0010702)2.09225086
72Orchitis (HP:0100796)2.08706314
73Hematochezia (HP:0002573)2.07824044
74Interstitial pulmonary disease (HP:0006530)2.07684756
75Chronic diarrhea (HP:0002028)2.05485216
76Colitis (HP:0002583)2.00979846
77Vasculitis (HP:0002633)2.00372208
78Recurrent skin infections (HP:0001581)2.00041770
79Recurrent gram-negative bacterial infections (HP:0005420)1.97745521
80J-shaped sella turcica (HP:0002680)1.97141834
81Memory impairment (HP:0002354)1.94383259
82Xanthomatosis (HP:0000991)1.94347770
83Urticaria (HP:0001025)1.93816729
84Mediastinal lymphadenopathy (HP:0100721)1.93544893
85Abnormality of the periventricular white matter (HP:0002518)1.91923692
86Disinhibition (HP:0000734)1.90933494
87Inappropriate behavior (HP:0000719)1.90751689
88Agnosia (HP:0010524)1.90554807
89Abnormal delayed hypersensitivity skin test (HP:0002963)1.88776710
90Premature loss of primary teeth (HP:0006323)1.88744780
91Postural instability (HP:0002172)1.87709033
92Inflammation of the large intestine (HP:0002037)1.86272838
93Adactyly (HP:0009776)1.84456402
94Increased IgE level (HP:0003212)1.84373741
95Hypoplastic left heart (HP:0004383)1.83954311
96Spontaneous hematomas (HP:0007420)1.83435936
97Hemorrhage of the eye (HP:0011885)1.82574874
98Increased CSF protein (HP:0002922)1.82529529
99Peripheral demyelination (HP:0011096)1.82083743
100Autoimmune thrombocytopenia (HP:0001973)1.81672853
101Optic neuritis (HP:0100653)1.81363624
102Retrobulbar optic neuritis (HP:0100654)1.81363624
103Diminished motivation (HP:0000745)1.81107771
104Sensorimotor neuropathy (HP:0007141)1.81082278
105Urinary incontinence (HP:0000020)1.80864284
106Gingivitis (HP:0000230)1.80812472
107Joint stiffness (HP:0001387)1.80274446
108Apathy (HP:0000741)1.79754449
109Cellulitis (HP:0100658)1.79554112
110Abnormality of the nasal mucosa (HP:0000433)1.79384938
111Malnutrition (HP:0004395)1.78419193
112Abnormality of the basal ganglia (HP:0002134)1.77773169
113Hydroxyprolinuria (HP:0003080)1.77248345
114Abnormality of proline metabolism (HP:0010907)1.77248345
115Asymmetric septal hypertrophy (HP:0001670)1.75012468
116Joint hemorrhage (HP:0005261)1.73734800
117Hepatosplenomegaly (HP:0001433)1.73059625
118Hyperparathyroidism (HP:0000843)1.72983143
119Bone cyst (HP:0012062)1.72874728
120Epileptic encephalopathy (HP:0200134)1.72836480
121Acrocyanosis (HP:0001063)1.72409183
122Pulmonary infiltrates (HP:0002113)1.71309121
123Partial duplication of the phalanx of hand (HP:0009999)1.70368765
124Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69264058
125Achilles tendon contracture (HP:0001771)1.69045799
126Abnormality of iron homeostasis (HP:0011031)1.68848455
127Aortic dissection (HP:0002647)1.68225064
128Cardiomegaly (HP:0001640)1.67974730
129Myocardial infarction (HP:0001658)1.67508073
130Craniofacial hyperostosis (HP:0004493)1.66976299
131Striae distensae (HP:0001065)1.65494088
132Epistaxis (HP:0000421)1.64040210
133Humeroradial synostosis (HP:0003041)1.63802518
134Synostosis involving the elbow (HP:0003938)1.63802518
135Hypertriglyceridemia (HP:0002155)1.62554858
136Aortic aneurysm (HP:0004942)1.61593460
137Delusions (HP:0000746)1.61586017
138Stomatitis (HP:0010280)1.61387353
139Bone pain (HP:0002653)1.60520678
140Arterial thrombosis (HP:0004420)1.58627630
141Abnormality of the Achilles tendon (HP:0005109)1.58591016
142Visual hallucinations (HP:0002367)1.56936486
143Hemoptysis (HP:0002105)1.56222214
144Rigidity (HP:0002063)1.54054952
145Hypertensive crisis (HP:0100735)1.54033851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.42849726
2NME24.01820722
3EPHA43.99000368
4LMTK23.51889095
5TESK13.30276804
6MAPK152.85256719
7MAP3K142.64834170
8MAP3K112.62281945
9TESK22.59942900
10GRK72.55526144
11PHKG22.48873199
12PHKG12.48873199
13RIPK12.46178314
14RIPK42.43735363
15IRAK32.29387303
16TAOK22.27220145
17TBK12.26553932
18PDK22.17534580
19CSF1R2.10803160
20PRPF4B2.09853700
21TYK22.05292727
22MAPK121.92244518
23LIMK11.92159950
24ABL21.85030548
25NTRK21.75988624
26MAP3K131.71847986
27DDR21.71840197
28MAP3K31.67555209
29BLK1.67193272
30PRKD31.65828565
31IRAK41.60317490
32DAPK21.55130800
33JAK11.51173370
34TNIK1.47388339
35IKBKB1.45241751
36TAOK11.44568289
37ERN11.42070810
38JAK31.28241938
39SIK11.27205121
40MAP2K31.25035363
41PAK61.24329774
42MAP3K11.20715759
43IKBKE1.17978248
44KIT1.17438006
45MOS1.07571497
46NEK91.05272045
47MAPK71.04336355
48EPHB11.04326481
49DAPK11.02538777
50ADRBK21.02393557
51JAK20.99605475
52FES0.97992654
53MATK0.97146553
54TRIB30.96875243
55HCK0.94612407
56LYN0.93876215
57SGK20.91959152
58DAPK30.89929867
59ARAF0.89210082
60CDC42BPA0.88698384
61MAP3K90.88477391
62NEK60.87377556
63SIK20.87025810
64BMPR20.86306332
65GRK50.83531628
66SYK0.81765947
67TNK20.78953771
68CAMKK10.78315506
69CAMK1D0.78182815
70FGR0.76785833
71PIK3CG0.76605728
72MAPK130.75934411
73MAP3K120.75194774
74CAMKK20.73866264
75MUSK0.71192166
76SGK30.69421877
77PIM20.69214592
78CAMK2G0.68280291
79EPHB20.67195028
80SIK30.66846291
81EPHA20.66237705
82IGF1R0.66072328
83BMX0.65111826
84CSK0.64624295
85FGFR30.63913495
86PDK10.63559389
87CLK10.63391654
88MAPKAPK30.63093240
89PRKG20.62768123
90SGK4940.61973439
91SGK2230.61973439
92HIPK20.59559350
93MARK20.59227369
94PRKCE0.58797402
95BCKDK0.58784256
96PTK60.58714948
97DMPK0.57836473
98BTK0.56836997
99INSRR0.56732196
100MAP4K10.54810434
101CDK190.54771900
102KDR0.54652311
103MYLK0.54025142
104ADRBK10.53238728
105TSSK60.53148926
106ICK0.52557682
107NTRK30.52023207
108PRKCQ0.51786245
109LCK0.50901606
110PBK0.48935796
111BRAF0.48782092
112CDK140.48525903
113PDPK10.48277520
114MAP2K60.48093121
115EPHA30.48001213
116CDK30.47867659
117PKN10.47503925
118MINK10.47338485
119PAK40.47297148
120IRAK10.46894818
121CDK150.46741782
122PRKCD0.46358882
123TYRO30.45439571
124TXK0.45117357
125CDK11A0.44841722
126IRAK20.44607758
127PRKD10.43843499
128CASK0.42597445
129CHUK0.42137523
130PAK10.42110320
131CAMK1G0.40632660
132ZAP700.40615799
133DYRK1B0.40259093
134CDK180.40243855
135FYN0.39999025
136CDK50.39112409
137ABL10.38430779
138MAP3K50.37580866
139PRKD20.37310270
140NTRK10.36450681
141CAMK2B0.36304965
142PRKCH0.35994879
143MAPKAPK20.33348067
144MAPK40.32497205
145MST40.31242196
146EGFR0.30952688
147RET0.29746172

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.82415924
2Asthma_Homo sapiens_hsa053103.14260604
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.83119731
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.79030581
5Fatty acid biosynthesis_Homo sapiens_hsa000612.78740211
6Other glycan degradation_Homo sapiens_hsa005112.77822830
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.67493777
8Staphylococcus aureus infection_Homo sapiens_hsa051502.50232642
9Lysosome_Homo sapiens_hsa041422.48372041
10Allograft rejection_Homo sapiens_hsa053301.88454371
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84591807
12Prion diseases_Homo sapiens_hsa050201.77294133
13Type I diabetes mellitus_Homo sapiens_hsa049401.73106031
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63439836
15Osteoclast differentiation_Homo sapiens_hsa043801.63416481
16Graft-versus-host disease_Homo sapiens_hsa053321.59493959
17Pertussis_Homo sapiens_hsa051331.47359566
18Leishmaniasis_Homo sapiens_hsa051401.42770032
19African trypanosomiasis_Homo sapiens_hsa051431.41275898
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36865529
21Collecting duct acid secretion_Homo sapiens_hsa049661.32209529
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.31854812
23Malaria_Homo sapiens_hsa051441.30597021
24Fatty acid metabolism_Homo sapiens_hsa012121.27932020
25Vibrio cholerae infection_Homo sapiens_hsa051101.26903565
26Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.24962088
27Autoimmune thyroid disease_Homo sapiens_hsa053201.20760777
28Rheumatoid arthritis_Homo sapiens_hsa053231.13426306
29Tuberculosis_Homo sapiens_hsa051521.12859231
30Chemokine signaling pathway_Homo sapiens_hsa040621.11346945
31B cell receptor signaling pathway_Homo sapiens_hsa046621.05567051
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05302089
33GABAergic synapse_Homo sapiens_hsa047271.02018374
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01671172
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00092092
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97567777
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97022523
38Glutamatergic synapse_Homo sapiens_hsa047240.96691362
39Toxoplasmosis_Homo sapiens_hsa051450.95252925
40Morphine addiction_Homo sapiens_hsa050320.94403114
41Hematopoietic cell lineage_Homo sapiens_hsa046400.94243864
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93637998
43Fatty acid degradation_Homo sapiens_hsa000710.93255138
44Galactose metabolism_Homo sapiens_hsa000520.91511798
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91025603
46Gastric acid secretion_Homo sapiens_hsa049710.90824782
47Cocaine addiction_Homo sapiens_hsa050300.89671639
48Antigen processing and presentation_Homo sapiens_hsa046120.89398473
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89252887
50Renin secretion_Homo sapiens_hsa049240.85315917
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83036450
52Legionellosis_Homo sapiens_hsa051340.82317529
53Insulin secretion_Homo sapiens_hsa049110.81037204
54Olfactory transduction_Homo sapiens_hsa047400.80588117
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78699666
56Nicotine addiction_Homo sapiens_hsa050330.78348520
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77123233
58* Salivary secretion_Homo sapiens_hsa049700.77002548
59Ether lipid metabolism_Homo sapiens_hsa005650.76661210
60Influenza A_Homo sapiens_hsa051640.75978313
61Measles_Homo sapiens_hsa051620.75443445
62Histidine metabolism_Homo sapiens_hsa003400.73556600
63Mineral absorption_Homo sapiens_hsa049780.71950722
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71545758
65Viral myocarditis_Homo sapiens_hsa054160.71287789
66Amoebiasis_Homo sapiens_hsa051460.70943297
67PPAR signaling pathway_Homo sapiens_hsa033200.70399351
68Circadian entrainment_Homo sapiens_hsa047130.70004281
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.69219944
70Salmonella infection_Homo sapiens_hsa051320.67807081
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67589378
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67498748
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67394836
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67387215
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67154865
76cAMP signaling pathway_Homo sapiens_hsa040240.66584110
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65723044
78Fructose and mannose metabolism_Homo sapiens_hsa000510.64548190
79Sphingolipid metabolism_Homo sapiens_hsa006000.64442287
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63627543
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61475289
82Glutathione metabolism_Homo sapiens_hsa004800.61321985
83Phagosome_Homo sapiens_hsa041450.61302903
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60777741
85Renin-angiotensin system_Homo sapiens_hsa046140.60568932
86TNF signaling pathway_Homo sapiens_hsa046680.59700085
87Complement and coagulation cascades_Homo sapiens_hsa046100.58627203
88Calcium signaling pathway_Homo sapiens_hsa040200.56679426
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.55204791
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.55014047
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54945627
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53822001
93Bladder cancer_Homo sapiens_hsa052190.53263147
94Hepatitis C_Homo sapiens_hsa051600.50763766
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.48373849
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.48367156
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48327562
98Herpes simplex infection_Homo sapiens_hsa051680.47318334
99Dorso-ventral axis formation_Homo sapiens_hsa043200.47307403
100Apoptosis_Homo sapiens_hsa042100.46766536
101Pancreatic secretion_Homo sapiens_hsa049720.46513766
102VEGF signaling pathway_Homo sapiens_hsa043700.46165415
103Phenylalanine metabolism_Homo sapiens_hsa003600.45498573
104Arachidonic acid metabolism_Homo sapiens_hsa005900.45055391
105Pentose phosphate pathway_Homo sapiens_hsa000300.44408092
106Serotonergic synapse_Homo sapiens_hsa047260.44173050
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.43813278
108Shigellosis_Homo sapiens_hsa051310.43323374
109Dilated cardiomyopathy_Homo sapiens_hsa054140.42258010
110Cholinergic synapse_Homo sapiens_hsa047250.42220191
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41646953
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.40430135
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.40146847
114GnRH signaling pathway_Homo sapiens_hsa049120.39295196
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.39215928
116ABC transporters_Homo sapiens_hsa020100.39086179
117Platelet activation_Homo sapiens_hsa046110.38608688
118Fatty acid elongation_Homo sapiens_hsa000620.37710911
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37702699
120Endocytosis_Homo sapiens_hsa041440.37551856
121Sulfur metabolism_Homo sapiens_hsa009200.37550364
122Bile secretion_Homo sapiens_hsa049760.36447648
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.34699195
124Circadian rhythm_Homo sapiens_hsa047100.34438761
125MAPK signaling pathway_Homo sapiens_hsa040100.34101588
126Estrogen signaling pathway_Homo sapiens_hsa049150.33896674
127Acute myeloid leukemia_Homo sapiens_hsa052210.32525679
128Sulfur relay system_Homo sapiens_hsa041220.32106818
129Pancreatic cancer_Homo sapiens_hsa052120.31903378
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31504890
131Synaptic vesicle cycle_Homo sapiens_hsa047210.31450735
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30636126
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29799847
134Long-term potentiation_Homo sapiens_hsa047200.27509117
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27476052
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25964850

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