CST13P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.78339919
2fusion of sperm to egg plasma membrane (GO:0007342)8.87525079
3regulation of phosphoprotein phosphatase activity (GO:0043666)8.44233681
4multicellular organism reproduction (GO:0032504)8.39323970
5binding of sperm to zona pellucida (GO:0007339)8.39130657
6sperm-egg recognition (GO:0035036)7.81621071
7axonemal dynein complex assembly (GO:0070286)7.56394646
8male meiosis (GO:0007140)7.45937824
9motile cilium assembly (GO:0044458)7.30630677
10reproduction (GO:0000003)6.83961942
11plasma membrane fusion (GO:0045026)6.82369916
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.81030095
13cell-cell recognition (GO:0009988)6.65763809
14cilium or flagellum-dependent cell motility (GO:0001539)6.48216960
15positive regulation of catecholamine secretion (GO:0033605)6.25133839
16sperm capacitation (GO:0048240)6.24010358
17protein-DNA complex disassembly (GO:0032986)6.23050123
18nucleosome disassembly (GO:0006337)6.23050123
19calcium ion-dependent exocytosis (GO:0017156)6.15979693
20single fertilization (GO:0007338)6.02473962
21microtubule depolymerization (GO:0007019)6.02312108
22chromosome condensation (GO:0030261)6.00033360
23phosphatidylethanolamine biosynthetic process (GO:0006646)5.98442007
24protein targeting to Golgi (GO:0000042)5.88722077
25epithelial cilium movement (GO:0003351)5.88539017
26DNA packaging (GO:0006323)5.70586092
27negative regulation of inclusion body assembly (GO:0090084)5.69433257
28germ cell development (GO:0007281)5.67834795
29establishment of protein localization to Golgi (GO:0072600)5.61688371
30organic cation transport (GO:0015695)5.61346091
31spermatid nucleus differentiation (GO:0007289)5.56650477
32polyamine biosynthetic process (GO:0006596)5.54410359
33protein polyglutamylation (GO:0018095)5.52270519
34phosphatidylethanolamine metabolic process (GO:0046337)5.49962302
35spermatogenesis (GO:0007283)5.48940338
36male gamete generation (GO:0048232)5.46849516
37retrograde transport, vesicle recycling within Golgi (GO:0000301)5.43097598
38gamete generation (GO:0007276)5.05394968
39rRNA methylation (GO:0031167)5.05107314
40microtubule polymerization or depolymerization (GO:0031109)5.02580743
41cilium movement (GO:0003341)4.93331859
42cellular process involved in reproduction in multicellular organism (GO:0022412)4.91603341
43centriole assembly (GO:0098534)4.90769879
44single strand break repair (GO:0000012)4.75569161
45fertilization (GO:0009566)4.71558474
46ventricular system development (GO:0021591)4.47172119
47response to acidic pH (GO:0010447)4.46419024
48male sex determination (GO:0030238)4.44551992
49coenzyme catabolic process (GO:0009109)4.43073480
50centriole replication (GO:0007099)4.34610961
51regulation of oxidative stress-induced neuron death (GO:1903203)4.28839468
52synapsis (GO:0007129)4.28489417
53potassium ion export (GO:0071435)4.23459035
54relaxation of smooth muscle (GO:0044557)4.22076376
55protein localization to Golgi apparatus (GO:0034067)4.15580138
56microtubule severing (GO:0051013)4.13183660
57rRNA modification (GO:0000154)4.12906657
58response to pheromone (GO:0019236)4.12117469
59multicellular organismal reproductive process (GO:0048609)4.08267834
60histone exchange (GO:0043486)3.92091469
61acrosome assembly (GO:0001675)3.86082313
62regulation of oxidative phosphorylation (GO:0002082)3.86005143
63regulation of inclusion body assembly (GO:0090083)3.85313881
64regulation of cilium movement (GO:0003352)3.85180371
65Leydig cell differentiation (GO:0033327)3.85095089
66histone H3-K9 demethylation (GO:0033169)3.79046639
67mitochondrion degradation (GO:0000422)3.76073110
68activation of protein kinase B activity (GO:0032148)3.71472414
69cellular biogenic amine biosynthetic process (GO:0042401)3.68860667
70cGMP-mediated signaling (GO:0019934)3.66412929
71sexual reproduction (GO:0019953)3.65556981
72positive regulation of Rab GTPase activity (GO:0032851)3.65099799
73regulation of Rab GTPase activity (GO:0032313)3.65099799
74positive regulation of glycolytic process (GO:0045821)3.63295563
75amine biosynthetic process (GO:0009309)3.59104141
76cellular response to pH (GO:0071467)3.58012943
77oogenesis (GO:0048477)3.52386989
78protein polymerization (GO:0051258)3.44167861
79regulation of dopamine secretion (GO:0014059)3.40935746
80seminiferous tubule development (GO:0072520)3.40609455
81detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.39743719
82regulation of centriole replication (GO:0046599)3.38714815
83meiotic nuclear division (GO:0007126)3.32290529
84regulation of transcription involved in cell fate commitment (GO:0060850)3.31246942
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27443682
86piRNA metabolic process (GO:0034587)3.26932082
87cell recognition (GO:0008037)3.26756785
88regulation of ARF GTPase activity (GO:0032312)3.25791298
89regulation of phosphatase activity (GO:0010921)3.24297917
90chromosome organization involved in meiosis (GO:0070192)3.23870978
91negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.20503617
92glutamine family amino acid catabolic process (GO:0009065)3.20241744
93cellular ketone body metabolic process (GO:0046950)3.15442324
94polyamine metabolic process (GO:0006595)3.01322780
95nucleus organization (GO:0006997)3.01062621
96receptor recycling (GO:0001881)2.94952300
97cell wall macromolecule metabolic process (GO:0044036)2.94296832
98regulation of autophagic vacuole assembly (GO:2000785)2.91328137
99acrosome reaction (GO:0007340)12.0901220
100sperm motility (GO:0030317)12.0622360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.07717408
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.45816679
3VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.06276933
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.00168435
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89375196
6IGF1R_20145208_ChIP-Seq_DFB_Human2.83677378
7FUS_26573619_Chip-Seq_HEK293_Human2.55396413
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53971022
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.53971022
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.52226822
11EZH2_22144423_ChIP-Seq_EOC_Human2.52195611
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29464715
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23715656
14CBP_20019798_ChIP-Seq_JUKART_Human2.17024933
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.17024933
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.13015633
17ARNT_22903824_ChIP-Seq_MCF-7_Human2.11150690
18NANOG_20526341_ChIP-Seq_ESCs_Human1.94721925
19RAC3_21632823_ChIP-Seq_H3396_Human1.91830237
20ER_23166858_ChIP-Seq_MCF-7_Human1.86888069
21ERA_21632823_ChIP-Seq_H3396_Human1.81433036
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.73845429
23CTCF_27219007_Chip-Seq_Bcells_Human1.72646936
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72578277
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.71963095
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71839927
27AR_21572438_ChIP-Seq_LNCaP_Human1.70488639
28AHR_22903824_ChIP-Seq_MCF-7_Human1.69383746
29MYC_19829295_ChIP-Seq_ESCs_Human1.61506389
30SMC4_20622854_ChIP-Seq_HELA_Human1.57310504
31OCT4_20526341_ChIP-Seq_ESCs_Human1.56485049
32SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54777806
33TP53_18474530_ChIP-ChIP_U2OS_Human1.52065276
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.50210745
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49509118
36TBL1_22424771_ChIP-Seq_293T_Human1.48185356
37ERG_20517297_ChIP-Seq_VCAP_Human1.47118130
38EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.44481396
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.44320221
40GBX2_23144817_ChIP-Seq_PC3_Human1.43453589
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.43103126
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41664443
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41618691
44P300_19829295_ChIP-Seq_ESCs_Human1.41555867
45OCT1_27270436_Chip-Seq_PROSTATE_Human1.40586425
46AR_25329375_ChIP-Seq_VCAP_Human1.31265591
47CTCF_20526341_ChIP-Seq_ESCs_Human1.31241429
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30169324
49RUNX2_22187159_ChIP-Seq_PCA_Human1.28170854
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23074940
51CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.23047159
52SMAD4_21799915_ChIP-Seq_A2780_Human1.22628959
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.19268266
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.18796608
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15967835
56NFYB_21822215_ChIP-Seq_K562_Human1.15546271
57TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13951526
58RBPJ_21746931_ChIP-Seq_IB4_Human1.13834991
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13673696
60PHF8_20622854_ChIP-Seq_HELA_Human1.13229105
61NANOG_19829295_ChIP-Seq_ESCs_Human1.12572628
62SOX2_19829295_ChIP-Seq_ESCs_Human1.12572628
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.12532934
64VDR_22108803_ChIP-Seq_LS180_Human1.12237594
65P300_27268052_Chip-Seq_Bcells_Human1.11769592
66P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11204602
67P68_20966046_ChIP-Seq_HELA_Human1.10544829
68PHF8_20622853_ChIP-Seq_HELA_Human1.10286458
69TP63_22573176_ChIP-Seq_HFKS_Human1.08742630
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07826347
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07443582
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07425935
73BCL6_27268052_Chip-Seq_Bcells_Human1.06098984
74ETV1_20927104_ChIP-Seq_GIST48_Human1.05854103
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.05821345
76STAT3_23295773_ChIP-Seq_U87_Human1.05378528
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.05290630
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04767753
79SPI1_20517297_ChIP-Seq_HL60_Human1.04245039
80LXR_22292898_ChIP-Seq_THP-1_Human1.02501002
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.01582891
82HOXB7_26014856_ChIP-Seq_BT474_Human1.01183397
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.99486503
84E2F1_20622854_ChIP-Seq_HELA_Human0.99376144
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.99133296
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98878836
87ZNF274_21170338_ChIP-Seq_K562_Hela0.98224668
88E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97198175
89DROSHA_22980978_ChIP-Seq_HELA_Human0.97153722
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.96506457
91GF1_26923725_Chip-Seq_HPCs_Mouse0.95067154
92NFYA_21822215_ChIP-Seq_K562_Human0.93905194
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93833012
94BCOR_27268052_Chip-Seq_Bcells_Human0.92223523
95CJUN_26792858_Chip-Seq_BT549_Human0.90981996
96TDRD3_21172665_ChIP-Seq_MCF-7_Human0.90791765
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.90624636
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.90159579
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89889762
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89449337

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003315_abnormal_perineum_morphology4.45851502
2MP0003698_abnormal_male_reproductive4.38324299
3MP0008004_abnormal_stomach_pH4.25955364
4MP0001929_abnormal_gametogenesis3.88269184
5MP0005377_hearing/vestibular/ear_phenot3.57727364
6MP0003878_abnormal_ear_physiology3.57727364
7MP0005360_urolithiasis2.59144994
8MP0002132_abnormal_respiratory_system2.52588069
9MP0005670_abnormal_white_adipose2.39042883
10MP0002161_abnormal_fertility/fecundity2.34320959
11MP0002160_abnormal_reproductive_system2.33921848
12MP0001984_abnormal_olfaction2.05120560
13MP0005410_abnormal_fertilization12.4801645
14MP0002210_abnormal_sex_determination1.94389591
15MP0003718_maternal_effect1.90788172
16MP0003045_fibrosis1.86204987
17MP0001145_abnormal_male_reproductive1.69665791
18MP0001348_abnormal_lacrimal_gland1.63286037
19MP0005647_abnormal_sex_gland1.62697586
20MP0000653_abnormal_sex_gland1.54358650
21MP0000678_abnormal_parathyroid_gland1.53080772
22MP0010386_abnormal_urinary_bladder1.48225963
23MP0005394_taste/olfaction_phenotype1.40402488
24MP0005499_abnormal_olfactory_system1.40402488
25MP0003136_yellow_coat_color1.36349893
26MP0001905_abnormal_dopamine_level1.34478131
27MP0009697_abnormal_copulation1.34202693
28MP0008995_early_reproductive_senescence1.33159597
29MP0001485_abnormal_pinna_reflex1.32911307
30MP0003879_abnormal_hair_cell1.27936997
31MP0010368_abnormal_lymphatic_system1.24953257
32MP0001664_abnormal_digestion1.21721976
33MP0005058_abnormal_lysosome_morphology1.20890751
34MP0005248_abnormal_Harderian_gland1.19973793
35MP0005395_other_phenotype1.19054509
36MP0002249_abnormal_larynx_morphology1.18160003
37MP0002127_abnormal_cardiovascular_syste1.14138969
38MP0001486_abnormal_startle_reflex1.12340546
39MP0003646_muscle_fatigue1.09905827
40MP0000537_abnormal_urethra_morphology1.08374782
41MP0005389_reproductive_system_phenotype1.06780900
42MP0005451_abnormal_body_composition1.02292983
43MP0000538_abnormal_urinary_bladder1.01710057
44MP0001188_hyperpigmentation1.00099970
45MP0002282_abnormal_trachea_morphology0.99124802
46MP0005253_abnormal_eye_physiology0.95325912
47MP0004085_abnormal_heartbeat0.92583508
48MP0004859_abnormal_synaptic_plasticity0.89308450
49MP0001501_abnormal_sleep_pattern0.87248047
50MP0004084_abnormal_cardiac_muscle0.86627408
51MP0001963_abnormal_hearing_physiology0.85310836
52MP0006072_abnormal_retinal_apoptosis0.84409818
53MP0003632_abnormal_nervous_system0.84104752
54MP0005187_abnormal_penis_morphology0.83981858
55MP0004742_abnormal_vestibular_system0.82383874
56MP0002138_abnormal_hepatobiliary_system0.81600501
57MP0003936_abnormal_reproductive_system0.77770510
58MP0005379_endocrine/exocrine_gland_phen0.77498043
59MP0000026_abnormal_inner_ear0.75121832
60MP0003631_nervous_system_phenotype0.75120219
61MP0001968_abnormal_touch/_nociception0.72137486
62MP0002168_other_aberrant_phenotype0.71937300
63MP0004036_abnormal_muscle_relaxation0.71684050
64MP0001849_ear_inflammation0.70443169
65MP0005423_abnormal_somatic_nervous0.69606378
66MP0000470_abnormal_stomach_morphology0.69320373
67MP0000230_abnormal_systemic_arterial0.67645560
68MP0005551_abnormal_eye_electrophysiolog0.67030570
69MP0002822_catalepsy0.62524369
70MP0008789_abnormal_olfactory_epithelium0.60016964
71MP0009115_abnormal_fat_cell0.59623294
72MP0000534_abnormal_ureter_morphology0.58188520
73MP0002272_abnormal_nervous_system0.57017788
74MP0003633_abnormal_nervous_system0.56034084
75MP0005595_abnormal_vascular_smooth0.54992732
76MP0001765_abnormal_ion_homeostasis0.53854024
77MP0000049_abnormal_middle_ear0.53730666
78MP0002067_abnormal_sensory_capabilities0.53111200
79MP0005167_abnormal_blood-brain_barrier0.51792898
80MP0004782_abnormal_surfactant_physiolog0.51148906
81MP0001919_abnormal_reproductive_system0.51141706
82MP0005409_darkened_coat_color0.51093658
83MP0002229_neurodegeneration0.51073717
84MP0000681_abnormal_thyroid_gland0.50352743
85MP0001270_distended_abdomen0.50280284
86MP0005646_abnormal_pituitary_gland0.47965710
87MP0008877_abnormal_DNA_methylation0.47337891
88MP0001529_abnormal_vocalization0.45148119
89MP0006036_abnormal_mitochondrial_physio0.45074845
90MP0004484_altered_response_of0.45065794
91MP0005391_vision/eye_phenotype0.45050267
92MP0000343_altered_response_to0.43549946
93MP0000955_abnormal_spinal_cord0.43440016
94MP0002735_abnormal_chemical_nociception0.43411284
95MP0003011_delayed_dark_adaptation0.43218076
96MP0003635_abnormal_synaptic_transmissio0.42926242
97MP0000465_gastrointestinal_hemorrhage0.42456276
98MP0002572_abnormal_emotion/affect_behav0.40147176
99MP0002557_abnormal_social/conspecific_i0.39507398
100MP0005166_decreased_susceptibility_to0.39142422

Predicted human phenotypes

RankGene SetZ-score
1Resting tremor (HP:0002322)7.66097768
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.25217807
3Absent/shortened dynein arms (HP:0200106)7.25217807
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.68568857
5Abnormal respiratory motile cilium physiology (HP:0012261)6.25900801
6Abnormal ciliary motility (HP:0012262)6.12202199
7Sex reversal (HP:0012245)5.74540960
8Abnormal sex determination (HP:0012244)5.74540960
9Infertility (HP:0000789)5.24848316
10Abnormal respiratory epithelium morphology (HP:0012253)5.18751181
11Abnormal respiratory motile cilium morphology (HP:0005938)5.18751181
12Hypoplasia of the uterus (HP:0000013)4.97490789
13Postural instability (HP:0002172)4.91895940
14Tubulointerstitial nephritis (HP:0001970)4.78875798
15Nasal polyposis (HP:0100582)4.60523366
16Chronic hepatic failure (HP:0100626)4.20162670
17Severe visual impairment (HP:0001141)4.04122536
18Gonadal dysgenesis (HP:0000133)3.96920862
19Abnormality of the nasal mucosa (HP:0000433)3.91536078
20Abnormality of the columella (HP:0009929)3.71729564
21Aplasia/hypoplasia of the uterus (HP:0008684)3.71293302
22Colitis (HP:0002583)3.61964069
23Rhinitis (HP:0012384)3.60038727
24Asymmetric septal hypertrophy (HP:0001670)3.43171588
25Male pseudohermaphroditism (HP:0000037)3.41665514
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.36829112
27Reduced antithrombin III activity (HP:0001976)3.32972343
28Abnormality of macular pigmentation (HP:0008002)3.31377371
29Cerebellar dysplasia (HP:0007033)3.28975968
30Bony spicule pigmentary retinopathy (HP:0007737)3.18346685
31Germ cell neoplasia (HP:0100728)3.14295952
32Male infertility (HP:0003251)3.10434912
33Attenuation of retinal blood vessels (HP:0007843)3.06767533
34Chronic bronchitis (HP:0004469)2.94114818
35Ventricular fibrillation (HP:0001663)2.81522635
36Type II lissencephaly (HP:0007260)2.80126591
37Bronchiectasis (HP:0002110)2.67476700
38Congenital sensorineural hearing impairment (HP:0008527)2.61967803
39Atonic seizures (HP:0010819)2.61648196
40Occipital encephalocele (HP:0002085)2.59995151
41Impulsivity (HP:0100710)2.59407291
42Abnormal rod and cone electroretinograms (HP:0008323)2.59112554
43Facial hemangioma (HP:0000329)2.58265647
44Thoracolumbar scoliosis (HP:0002944)2.56940958
45Sensory axonal neuropathy (HP:0003390)2.53913190
46Abnormality of dental color (HP:0011073)2.52924888
47Cone-rod dystrophy (HP:0000548)2.50500728
48Hyperkalemia (HP:0002153)2.46175698
49Self-mutilation (HP:0000742)2.45037339
50Aplasia/Hypoplasia of the earlobes (HP:0009906)2.39753493
51Retinal atrophy (HP:0001105)2.39500390
52Retinal dysplasia (HP:0007973)2.37191484
53Inflammation of the large intestine (HP:0002037)2.28042413
54Thoracic kyphosis (HP:0002942)2.27418338
55Abnormal drinking behavior (HP:0030082)2.25333756
56Polydipsia (HP:0001959)2.25333756
57Hypoalphalipoproteinemia (HP:0003233)2.23350696
58Renal dysplasia (HP:0000110)2.22493382
59Hypoplasia of the thymus (HP:0000778)2.21650836
60Urinary urgency (HP:0000012)2.20662396
61Optic nerve hypoplasia (HP:0000609)2.19646146
62Anterior segment dysgenesis (HP:0007700)2.18923679
63Bell-shaped thorax (HP:0001591)2.15167396
64Flattened epiphyses (HP:0003071)2.13703567
65Facial shape deformation (HP:0011334)2.05525043
66Potter facies (HP:0002009)2.05525043
67Gastrointestinal inflammation (HP:0004386)2.04777760
68Menstrual irregularities (HP:0000858)2.04602593
69Renovascular hypertension (HP:0100817)2.01489882
70Abnormal urine output (HP:0012590)1.97866726
71Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.96980942
72Progressive sensorineural hearing impairment (HP:0000408)1.96923271
73Tubulointerstitial abnormality (HP:0001969)1.95555910
74Progressive cerebellar ataxia (HP:0002073)1.94275346
75Abnormal spermatogenesis (HP:0008669)1.89956253
76Recurrent corneal erosions (HP:0000495)1.85478198
77Azoospermia (HP:0000027)1.84566306
78Truncal obesity (HP:0001956)1.83349614
79Abnormality of the lumbar spine (HP:0100712)1.79536303
80Atrial fibrillation (HP:0005110)1.79186668
81Buphthalmos (HP:0000557)1.79114416
82Protruding tongue (HP:0010808)1.78456437
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75915880
84Stage 5 chronic kidney disease (HP:0003774)1.74509580
85Polyuria (HP:0000103)1.72360150
86Amelogenesis imperfecta (HP:0000705)1.72061633
87Portal hypertension (HP:0001409)1.71751652
88Bradykinesia (HP:0002067)1.70851819
89Abnormality of the hepatic vasculature (HP:0006707)1.70211484
90Photophobia (HP:0000613)1.69677320
91Abnormality of renal excretion (HP:0011036)1.67984931
92Inability to walk (HP:0002540)1.66884117
93Insulin-resistant diabetes mellitus (HP:0000831)1.64210989
94Abnormality of the intrinsic pathway (HP:0010989)1.63863856
95Abnormality of male internal genitalia (HP:0000022)1.63430557
96Capillary hemangiomas (HP:0005306)1.62771080
97Hypoplastic ischia (HP:0003175)1.62672596
98Abnormality of the ileum (HP:0001549)1.62209126
99Primary atrial arrhythmia (HP:0001692)1.60993716
100Type II diabetes mellitus (HP:0005978)1.60823162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK19.74767732
2PLK45.46706110
3MARK35.03679095
4TLK13.05317099
5ZAK3.00262908
6STK382.56586662
7MYLK2.53929758
8INSRR2.43590006
9BRD42.25261854
10RPS6KA52.24964344
11STK38L2.07002337
12TESK12.00536727
13LATS11.90355426
14NEK21.87944858
15PLK21.83790030
16MAPK151.72704405
17DDR21.70333433
18MST1R1.61651499
19PNCK1.48521151
20CAMK1G1.29679939
21PRKD31.28144066
22LATS21.25494223
23MAP4K21.23618685
24CDK31.21152738
25PIK3CG1.19974980
26PDPK11.09804073
27MAP3K91.08618468
28SGK2231.07455931
29SGK4941.07455931
30MAP2K71.07376655
31PDK11.00548582
32CDK120.93525904
33PTK2B0.90478776
34TYRO30.83103685
35WNK10.80963995
36TIE10.80515570
37PRKG20.78152853
38BMPR1B0.77284225
39ARAF0.75286064
40FRK0.73004104
41DYRK30.67655759
42PRKCQ0.65736768
43NEK60.65101309
44MAP3K10.63284238
45VRK10.61871098
46CAMK10.58761891
47PRKG10.56226359
48CDK140.54916212
49BRAF0.54276743
50ROCK10.53419353
51OBSCN0.52304266
52CDC42BPA0.47129290
53KSR20.46284296
54AKT30.45312239
55MAP3K130.45270552
56CSNK1A1L0.44988551
57PKN10.44966519
58FGFR20.43127528
59CDK70.42450306
60CAMK1D0.41939070
61PAK10.40303519
62RPS6KA10.39797047
63PAK20.38210695
64CSNK1G30.33974375
65DYRK20.33317159
66MTOR0.32141079
67MAPK10.30905260
68CDK50.30421243
69SGK20.29446293
70DYRK1B0.28504617
71MAP3K100.25881375
72RPS6KA20.25241431
73MOS0.22790973
74ATM0.22315163
75SIK20.21833954
76CSNK1G10.20083462
77GSK3B0.19738354
78CSNK1A10.18728572
79CSNK1G20.18711310
80ADRBK20.18510696
81RET0.18393915
82FGR0.17686763
83EGFR0.17194994
84ICK0.15741859
85RPS6KA30.15486052
86TGFBR10.15416923
87MET0.15390616
88PRKAA20.15238564
89CDK10.14865953
90CAMK40.14666819
91DAPK30.12498452
92MAP3K80.12497759
93MELK0.12219114
94SGK10.11800212
95EEF2K0.10762842
96MAP3K20.10624475
97RPS6KB10.09633503
98CDK20.09502003
99MUSK0.07627111
100GRK60.06273608

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051306.21006724
2Gap junction_Homo sapiens_hsa045404.42982121
3Fatty acid biosynthesis_Homo sapiens_hsa000613.84371808
4Olfactory transduction_Homo sapiens_hsa047403.60579615
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.43656705
6Hedgehog signaling pathway_Homo sapiens_hsa043403.07317289
7Nitrogen metabolism_Homo sapiens_hsa009102.90394655
8Systemic lupus erythematosus_Homo sapiens_hsa053222.54916996
9Arginine biosynthesis_Homo sapiens_hsa002202.53572404
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.45400953
11Phagosome_Homo sapiens_hsa041452.29478698
12Apoptosis_Homo sapiens_hsa042102.25987198
13Butanoate metabolism_Homo sapiens_hsa006502.23507206
14Alcoholism_Homo sapiens_hsa050341.99741376
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93831137
16Dorso-ventral axis formation_Homo sapiens_hsa043201.86716745
17Propanoate metabolism_Homo sapiens_hsa006401.60128725
18Phenylalanine metabolism_Homo sapiens_hsa003601.46675131
19Taste transduction_Homo sapiens_hsa047421.42993776
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.33393662
21Fatty acid degradation_Homo sapiens_hsa000711.17834523
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.12086350
23RNA transport_Homo sapiens_hsa030131.09143942
24PPAR signaling pathway_Homo sapiens_hsa033201.06032050
25Oocyte meiosis_Homo sapiens_hsa041141.04821063
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.01167116
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99965798
28Renin secretion_Homo sapiens_hsa049240.92486259
29Pyruvate metabolism_Homo sapiens_hsa006200.91229772
30cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87731471
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87631479
32Glutathione metabolism_Homo sapiens_hsa004800.87563825
33Glucagon signaling pathway_Homo sapiens_hsa049220.79286835
34Fatty acid metabolism_Homo sapiens_hsa012120.76994204
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74800346
36Chemical carcinogenesis_Homo sapiens_hsa052040.74390593
37Calcium signaling pathway_Homo sapiens_hsa040200.71098156
38Gastric acid secretion_Homo sapiens_hsa049710.68369238
39Oxytocin signaling pathway_Homo sapiens_hsa049210.67883266
40mRNA surveillance pathway_Homo sapiens_hsa030150.65791925
41Tyrosine metabolism_Homo sapiens_hsa003500.65669067
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64232746
43Type II diabetes mellitus_Homo sapiens_hsa049300.62845753
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62843366
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62380845
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62312256
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58744267
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56593191
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56017807
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53649497
51Circadian entrainment_Homo sapiens_hsa047130.52982631
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51084395
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51021542
54Estrogen signaling pathway_Homo sapiens_hsa049150.49896145
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49858774
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49566943
57Basal transcription factors_Homo sapiens_hsa030220.49374483
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48817895
59Phototransduction_Homo sapiens_hsa047440.48793710
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48421935
61Synaptic vesicle cycle_Homo sapiens_hsa047210.48230693
62Purine metabolism_Homo sapiens_hsa002300.47954124
63Salivary secretion_Homo sapiens_hsa049700.47687317
64Tryptophan metabolism_Homo sapiens_hsa003800.45482936
65Long-term potentiation_Homo sapiens_hsa047200.45225724
66Protein digestion and absorption_Homo sapiens_hsa049740.44980517
67Fanconi anemia pathway_Homo sapiens_hsa034600.44893142
68cAMP signaling pathway_Homo sapiens_hsa040240.42733791
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42143969
70Arginine and proline metabolism_Homo sapiens_hsa003300.39881691
71Glycerolipid metabolism_Homo sapiens_hsa005610.37196892
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.37113740
73Circadian rhythm_Homo sapiens_hsa047100.36693484
74Retinol metabolism_Homo sapiens_hsa008300.35430494
75Inositol phosphate metabolism_Homo sapiens_hsa005620.35257576
76VEGF signaling pathway_Homo sapiens_hsa043700.35210041
77ECM-receptor interaction_Homo sapiens_hsa045120.35072030
78Glutamatergic synapse_Homo sapiens_hsa047240.33437386
79MAPK signaling pathway_Homo sapiens_hsa040100.32913752
80Influenza A_Homo sapiens_hsa051640.32372622
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31038543
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30857457
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.29439155
84Nicotine addiction_Homo sapiens_hsa050330.27844663
85B cell receptor signaling pathway_Homo sapiens_hsa046620.27783965
86Type I diabetes mellitus_Homo sapiens_hsa049400.26976683
87Choline metabolism in cancer_Homo sapiens_hsa052310.26785637
88Amphetamine addiction_Homo sapiens_hsa050310.26724096
89Endocytosis_Homo sapiens_hsa041440.26285290
90Wnt signaling pathway_Homo sapiens_hsa043100.24771989
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24460611
92beta-Alanine metabolism_Homo sapiens_hsa004100.23629564
93Prostate cancer_Homo sapiens_hsa052150.22541963
94ABC transporters_Homo sapiens_hsa020100.22393780
95Morphine addiction_Homo sapiens_hsa050320.22051780
96TGF-beta signaling pathway_Homo sapiens_hsa043500.21610707
97Antigen processing and presentation_Homo sapiens_hsa046120.20963287
98Metabolic pathways_Homo sapiens_hsa011000.18287218
99Carbon metabolism_Homo sapiens_hsa012000.18235619
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.17910460

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