CSRNP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.59231372
2vocalization behavior (GO:0071625)5.57895550
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.45564652
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.31547989
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16601486
6protein localization to synapse (GO:0035418)5.14633232
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.97216713
8synaptic vesicle exocytosis (GO:0016079)4.90412925
9regulation of glutamate receptor signaling pathway (GO:1900449)4.90321372
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.62254950
11synaptic vesicle maturation (GO:0016188)4.57808597
12neuron recognition (GO:0008038)4.54268454
13dendritic spine morphogenesis (GO:0060997)4.50604209
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.45428259
15pyrimidine nucleobase catabolic process (GO:0006208)4.44744299
16glutamate secretion (GO:0014047)4.43368092
17locomotory exploration behavior (GO:0035641)4.43230455
18regulation of synaptic vesicle exocytosis (GO:2000300)4.38081522
19axonal fasciculation (GO:0007413)4.36524465
20layer formation in cerebral cortex (GO:0021819)4.31810239
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.26285747
22glutamate receptor signaling pathway (GO:0007215)4.20792149
23regulation of synapse structural plasticity (GO:0051823)4.12608170
24exploration behavior (GO:0035640)4.11899996
25synaptic transmission, glutamatergic (GO:0035249)4.06408154
26presynaptic membrane assembly (GO:0097105)4.04684056
27cell migration in hindbrain (GO:0021535)4.04616852
28neuron-neuron synaptic transmission (GO:0007270)4.02291873
29neurotransmitter-gated ion channel clustering (GO:0072578)3.93742384
30regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.93388412
31neurotransmitter secretion (GO:0007269)3.88740210
32neuronal action potential propagation (GO:0019227)3.87855273
33presynaptic membrane organization (GO:0097090)3.87691112
34response to pheromone (GO:0019236)3.83978251
35regulation of synaptic vesicle transport (GO:1902803)3.83282891
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.81486148
37postsynaptic membrane organization (GO:0001941)3.77672587
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75584686
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.73319757
40regulation of neuronal synaptic plasticity (GO:0048168)3.73016657
41dendrite morphogenesis (GO:0048813)3.71647501
42central nervous system projection neuron axonogenesis (GO:0021952)3.68821070
43nucleobase catabolic process (GO:0046113)3.67286582
44startle response (GO:0001964)3.66402850
45positive regulation of synapse maturation (GO:0090129)3.62940973
46positive regulation of synapse assembly (GO:0051965)3.60872581
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59052710
48establishment of mitochondrion localization (GO:0051654)3.57257546
49regulation of postsynaptic membrane potential (GO:0060078)3.56920206
50transmission of nerve impulse (GO:0019226)3.56391043
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.55544268
52proline transport (GO:0015824)3.47209908
53auditory behavior (GO:0031223)3.46812286
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46568885
55regulation of respiratory system process (GO:0044065)3.45461795
56negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.44965408
57membrane hyperpolarization (GO:0060081)3.44314461
58positive regulation of membrane potential (GO:0045838)3.39707252
59gamma-aminobutyric acid signaling pathway (GO:0007214)3.39155739
60cerebellar Purkinje cell differentiation (GO:0021702)3.39147361
61gamma-aminobutyric acid transport (GO:0015812)3.39079749
62long-term memory (GO:0007616)3.38214889
63synapse assembly (GO:0007416)3.37773049
64negative regulation of microtubule polymerization (GO:0031115)3.33821185
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.32396696
66cerebral cortex radially oriented cell migration (GO:0021799)3.30338839
67regulation of dendritic spine morphogenesis (GO:0061001)3.29545601
68neurotransmitter transport (GO:0006836)3.26418678
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25883764
70regulation of respiratory gaseous exchange (GO:0043576)3.25443980
71dendrite development (GO:0016358)3.25395327
72righting reflex (GO:0060013)3.25142764
73response to auditory stimulus (GO:0010996)3.21502868
74synaptic vesicle endocytosis (GO:0048488)3.21155068
75innervation (GO:0060384)3.19285517
76retinal ganglion cell axon guidance (GO:0031290)3.17928354
77membrane depolarization during action potential (GO:0086010)3.15707786
78behavioral defense response (GO:0002209)3.14538920
79behavioral fear response (GO:0001662)3.14538920
80membrane depolarization (GO:0051899)3.14153306
81response to histamine (GO:0034776)3.12953473
82regulation of synapse assembly (GO:0051963)3.11414202
83neuronal action potential (GO:0019228)3.11059540
84regulation of neurotransmitter secretion (GO:0046928)3.09913961
85prepulse inhibition (GO:0060134)3.07390460
86behavioral response to nicotine (GO:0035095)3.06710852
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06501437
88regulation of synapse maturation (GO:0090128)3.05539731
89negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05529309
90negative regulation of dendrite development (GO:2000171)3.04602217
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.04128261
92long-term synaptic potentiation (GO:0060291)3.03290724
93learning (GO:0007612)3.03036565
94regulation of synaptic plasticity (GO:0048167)3.02689301
95regulation of vesicle fusion (GO:0031338)3.02375035
96mitochondrion transport along microtubule (GO:0047497)3.00140513
97establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00140513
98synapse organization (GO:0050808)3.00104871
99mechanosensory behavior (GO:0007638)3.00009030
100calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.99737513
101regulation of synapse organization (GO:0050807)2.97269011
102positive regulation of dendritic spine development (GO:0060999)2.97201345
103social behavior (GO:0035176)2.94973716
104intraspecies interaction between organisms (GO:0051703)2.94973716
105fear response (GO:0042596)2.93153980
106regulation of dendritic spine development (GO:0060998)2.93136537
107regulation of neurotransmitter levels (GO:0001505)2.92726605
108neuronal ion channel clustering (GO:0045161)2.91653497
109glycosphingolipid biosynthetic process (GO:0006688)2.89814914
110central nervous system neuron axonogenesis (GO:0021955)2.88814250
111limb bud formation (GO:0060174)2.88455152
112positive regulation of potassium ion transmembrane transport (GO:1901381)2.85280091
113short-term memory (GO:0007614)2.85264285
114hippocampus development (GO:0021766)2.83732231
115negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80894098
116atrial cardiac muscle cell action potential (GO:0086014)2.79643806
117axon extension (GO:0048675)2.78279012
118protein localization to cilium (GO:0061512)2.74735060
119heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.74169553
120axonogenesis (GO:0007409)2.73702298
121adult walking behavior (GO:0007628)2.73391222
122spinal cord development (GO:0021510)2.72394646
123nonmotile primary cilium assembly (GO:0035058)2.72228483
124regulation of feeding behavior (GO:0060259)2.72016726
125cochlea development (GO:0090102)2.71554132
126epithelial cell differentiation involved in kidney development (GO:0035850)2.70221860
127neuron migration (GO:0001764)2.68902779
128nerve growth factor signaling pathway (GO:0038180)2.67677382
129regulation of axon guidance (GO:1902667)2.67180111
130cerebellar granule cell differentiation (GO:0021707)2.67013913
131adult behavior (GO:0030534)2.61635026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.48980461
2GBX2_23144817_ChIP-Seq_PC3_Human4.08943189
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99903184
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97943002
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82133852
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.72431497
7REST_21632747_ChIP-Seq_MESCs_Mouse2.65719119
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51657368
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51657368
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50140317
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49701531
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46730086
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43294378
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34018660
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.31522561
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25559581
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25456238
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.23862079
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23838021
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22108427
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21247132
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20618879
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20384874
24TAF15_26573619_Chip-Seq_HEK293_Human2.15737769
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.14171981
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.11248483
27DROSHA_22980978_ChIP-Seq_HELA_Human2.09474643
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06586513
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02548150
30* RARB_27405468_Chip-Seq_BRAIN_Mouse1.99335695
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98468041
32AR_21572438_ChIP-Seq_LNCaP_Human1.98311031
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98096679
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.91701825
35IGF1R_20145208_ChIP-Seq_DFB_Human1.89388255
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82116124
37ZNF274_21170338_ChIP-Seq_K562_Hela1.80952980
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73032176
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68891199
40RNF2_27304074_Chip-Seq_NSC_Mouse1.65951523
41SMAD4_21799915_ChIP-Seq_A2780_Human1.65648867
42* P300_19829295_ChIP-Seq_ESCs_Human1.63082946
43EWS_26573619_Chip-Seq_HEK293_Human1.57705568
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55879841
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.53624792
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49985790
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48579688
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.46278995
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46216362
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40914989
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39473991
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38219091
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33716208
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.33086391
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.31794181
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.31746593
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30043037
58AR_25329375_ChIP-Seq_VCAP_Human1.30000580
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28839721
60FUS_26573619_Chip-Seq_HEK293_Human1.27276244
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26281929
62* PIAS1_25552417_ChIP-Seq_VCAP_Human1.25262382
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24512598
64STAT3_23295773_ChIP-Seq_U87_Human1.22526921
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20910253
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19424538
67VDR_22108803_ChIP-Seq_LS180_Human1.19211241
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18963907
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17616017
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17053147
71* RING1B_27294783_Chip-Seq_NPCs_Mouse1.16931909
72* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16750696
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15822272
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15822272
75AR_19668381_ChIP-Seq_PC3_Human1.14801244
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14183702
77* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14060660
78* CBP_20019798_ChIP-Seq_JUKART_Human1.14060660
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.13750842
80SOX9_26525672_Chip-Seq_HEART_Mouse1.13473404
81ER_23166858_ChIP-Seq_MCF-7_Human1.13420106
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12028772
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11616001
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.10497352
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09698233
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09427263
87BCAT_22108803_ChIP-Seq_LS180_Human1.09313786
88* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09220288
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08479942
90* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07918030
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.07895258
92TCF4_23295773_ChIP-Seq_U87_Human1.07398900
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06908685
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05312091
95* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04961140
96AHR_22903824_ChIP-Seq_MCF-7_Human1.04873261
97* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02687297
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.01996354
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.01066119
100* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00157068
101JUN_21703547_ChIP-Seq_K562_Human1.00104589
102* P53_22387025_ChIP-Seq_ESCs_Mouse0.99679530
103* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99644406
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97157667
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.94177242
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92597401
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91773692
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.91400197
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91097501
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90354555
111WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90138499
112* KDM2B_26808549_Chip-Seq_REH_Human0.87933694
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87287831
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87066240
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.87046990
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86782783
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85980136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.35739502
2MP0003880_abnormal_central_pattern4.89825126
3MP0003635_abnormal_synaptic_transmissio3.77181422
4MP0004270_analgesia3.50322574
5MP0005423_abnormal_somatic_nervous3.27817964
6MP0002063_abnormal_learning/memory/cond3.20704121
7MP0001968_abnormal_touch/_nociception3.07228776
8MP0009745_abnormal_behavioral_response3.05667312
9MP0002064_seizures2.86707245
10MP0009046_muscle_twitch2.86276599
11MP0002572_abnormal_emotion/affect_behav2.73121177
12MP0006276_abnormal_autonomic_nervous2.69241267
13MP0002734_abnormal_mechanical_nocicepti2.66622991
14MP0001486_abnormal_startle_reflex2.60631965
15MP0000778_abnormal_nervous_system2.53389060
16MP0002735_abnormal_chemical_nociception2.45196642
17MP0002272_abnormal_nervous_system2.39611351
18MP0002736_abnormal_nociception_after2.26838935
19MP0002184_abnormal_innervation2.22121715
20MP0001529_abnormal_vocalization2.21245663
21MP0001440_abnormal_grooming_behavior2.15157068
22MP0002733_abnormal_thermal_nociception2.12609605
23MP0002067_abnormal_sensory_capabilities2.04343593
24MP0001970_abnormal_pain_threshold1.95112992
25MP0002557_abnormal_social/conspecific_i1.92998601
26MP0004924_abnormal_behavior1.91199345
27MP0005386_behavior/neurological_phenoty1.91199345
28MP0002822_catalepsy1.89630929
29MP0003122_maternal_imprinting1.84192688
30MP0001501_abnormal_sleep_pattern1.83257879
31MP0004811_abnormal_neuron_physiology1.74740246
32MP0003787_abnormal_imprinting1.70494204
33MP0001984_abnormal_olfaction1.69228716
34MP0000955_abnormal_spinal_cord1.62748411
35MP0005645_abnormal_hypothalamus_physiol1.57297152
36MP0000569_abnormal_digit_pigmentation1.56996162
37MP0002882_abnormal_neuron_morphology1.56685412
38MP0005646_abnormal_pituitary_gland1.55517962
39MP0001188_hyperpigmentation1.49380336
40MP0001905_abnormal_dopamine_level1.48141667
41MP0004142_abnormal_muscle_tone1.46934599
42MP0000566_synostosis1.45859263
43MP0003329_amyloid_beta_deposits1.42649323
44MP0008569_lethality_at_weaning1.41369881
45MP0002066_abnormal_motor_capabilities/c1.40422272
46MP0001502_abnormal_circadian_rhythm1.33072239
47MP0002152_abnormal_brain_morphology1.29722910
48MP0004858_abnormal_nervous_system1.27546163
49MP0004742_abnormal_vestibular_system1.27020146
50MP0002909_abnormal_adrenal_gland1.24973659
51MP0009780_abnormal_chondrocyte_physiolo1.22832664
52MP0004885_abnormal_endolymph1.22412221
53MP0005248_abnormal_Harderian_gland1.20431890
54MP0003283_abnormal_digestive_organ1.20045849
55MP0005551_abnormal_eye_electrophysiolog1.19344543
56MP0000631_abnormal_neuroendocrine_gland1.19125607
57MP0008877_abnormal_DNA_methylation1.18835949
58MP0003879_abnormal_hair_cell1.15196014
59MP0002102_abnormal_ear_morphology1.14557422
60MP0002234_abnormal_pharynx_morphology1.13194589
61MP0002638_abnormal_pupillary_reflex1.08280881
62MP0010386_abnormal_urinary_bladder1.04950324
63MP0002752_abnormal_somatic_nervous1.04606567
64MP0003119_abnormal_digestive_system1.02122757
65MP0003121_genomic_imprinting1.01348898
66MP0002938_white_spotting1.01173474
67MP0005499_abnormal_olfactory_system1.00336768
68MP0005394_taste/olfaction_phenotype1.00336768
69MP0001963_abnormal_hearing_physiology0.98367835
70MP0002069_abnormal_eating/drinking_beha0.95530400
71MP0003861_abnormal_nervous_system0.94838260
72MP0000751_myopathy0.93731833
73MP0000049_abnormal_middle_ear0.93067829
74MP0006072_abnormal_retinal_apoptosis0.92866113
75MP0002229_neurodegeneration0.92349636
76MP0002751_abnormal_autonomic_nervous0.90868169
77MP0003137_abnormal_impulse_conducting0.90520656
78MP0003937_abnormal_limbs/digits/tail_de0.88995996
79MP0003633_abnormal_nervous_system0.88924093
80MP0005195_abnormal_posterior_eye0.88638593
81MP0003631_nervous_system_phenotype0.84714695
82MP0005409_darkened_coat_color0.84580517
83MP0004085_abnormal_heartbeat0.83977955
84MP0000026_abnormal_inner_ear0.83679503
85MP0004145_abnormal_muscle_electrophysio0.81616533
86MP0006292_abnormal_olfactory_placode0.81327525
87MP0003634_abnormal_glial_cell0.78282372
88MP0003890_abnormal_embryonic-extraembry0.75072876
89MP0002837_dystrophic_cardiac_calcinosis0.74103841
90MP0002233_abnormal_nose_morphology0.72744727
91MP0002653_abnormal_ependyma_morphology0.72402742
92MP0003938_abnormal_ear_development0.72208372
93MP0008872_abnormal_physiological_respon0.71238143
94MP0003136_yellow_coat_color0.70622284
95MP0000647_abnormal_sebaceous_gland0.68703699
96MP0001177_atelectasis0.67154192
97MP0000516_abnormal_urinary_system0.67018281
98MP0001943_abnormal_respiration0.66104074
99MP0003632_abnormal_nervous_system0.65975204
100MP0001485_abnormal_pinna_reflex0.65047974
101MP0002876_abnormal_thyroid_physiology0.64861772
102MP0005253_abnormal_eye_physiology0.64854054
103MP0008789_abnormal_olfactory_epithelium0.63020951
104MP0004133_heterotaxia0.62920240
105MP0010770_preweaning_lethality0.62275115
106MP0002082_postnatal_lethality0.62275115
107MP0001299_abnormal_eye_distance/0.61155925
108MP0005535_abnormal_body_temperature0.60755306
109MP0010769_abnormal_survival0.60083948
110MP0004215_abnormal_myocardial_fiber0.57358955
111MP0010768_mortality/aging0.57135828
112MP0005187_abnormal_penis_morphology0.56570278
113MP0008961_abnormal_basal_metabolism0.53874708
114MP0002081_perinatal_lethality0.53501818

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.47304783
2Myokymia (HP:0002411)5.60232232
3Focal seizures (HP:0007359)5.01396437
4Epileptic encephalopathy (HP:0200134)4.52991876
5Febrile seizures (HP:0002373)4.24747887
6Broad-based gait (HP:0002136)4.06396723
7Hyperventilation (HP:0002883)3.98638217
8Progressive cerebellar ataxia (HP:0002073)3.88350241
9Atonic seizures (HP:0010819)3.83222266
10Visual hallucinations (HP:0002367)3.79583505
11Absence seizures (HP:0002121)3.49958308
12Drooling (HP:0002307)3.40151006
13Excessive salivation (HP:0003781)3.40151006
14Generalized tonic-clonic seizures (HP:0002069)3.24105021
15Dialeptic seizures (HP:0011146)3.23699437
16Polyphagia (HP:0002591)3.18988677
17Progressive inability to walk (HP:0002505)3.18379854
18Mutism (HP:0002300)3.16367823
19Limb dystonia (HP:0002451)3.14075702
20Amblyopia (HP:0000646)3.07617093
21Ankle clonus (HP:0011448)3.00678839
22Poor eye contact (HP:0000817)3.00221694
23Supranuclear gaze palsy (HP:0000605)2.95188921
24Truncal ataxia (HP:0002078)2.94433593
25Abnormal eating behavior (HP:0100738)2.87910073
26Impaired vibration sensation in the lower limbs (HP:0002166)2.76780249
27Action tremor (HP:0002345)2.71624779
28Absent speech (HP:0001344)2.68115534
29Hemiparesis (HP:0001269)2.64408667
30Inability to walk (HP:0002540)2.63842432
31Impaired social interactions (HP:0000735)2.63553447
32Abnormal social behavior (HP:0012433)2.63553447
33Abnormality of the corticospinal tract (HP:0002492)2.60379736
34Gaze-evoked nystagmus (HP:0000640)2.58452968
35Amyotrophic lateral sclerosis (HP:0007354)2.57604135
36Abnormal hair whorl (HP:0010721)2.56186270
37Genital tract atresia (HP:0001827)2.55148365
38Nephronophthisis (HP:0000090)2.54796144
39Epileptiform EEG discharges (HP:0011182)2.52827431
40Hepatoblastoma (HP:0002884)2.52720616
41Pachygyria (HP:0001302)2.50358607
42Urinary bladder sphincter dysfunction (HP:0002839)2.47832947
43Vaginal atresia (HP:0000148)2.47510154
44Urinary urgency (HP:0000012)2.46469979
45Hypoplasia of the brainstem (HP:0002365)2.45435199
46Aplasia/Hypoplasia of the brainstem (HP:0007362)2.45435199
47Exotropia (HP:0000577)2.44446070
48Depression (HP:0000716)2.43898528
49Termporal pattern (HP:0011008)2.43855719
50Insidious onset (HP:0003587)2.43855719
51Spastic gait (HP:0002064)2.43300041
52EEG with generalized epileptiform discharges (HP:0011198)2.43099499
53Nephrogenic diabetes insipidus (HP:0009806)2.41828843
54Protruding tongue (HP:0010808)2.41299820
55Gait imbalance (HP:0002141)2.40922243
56True hermaphroditism (HP:0010459)2.39966248
57Dysdiadochokinesis (HP:0002075)2.39628467
58Failure to thrive in infancy (HP:0001531)2.39557429
59Pancreatic fibrosis (HP:0100732)2.35396686
60Molar tooth sign on MRI (HP:0002419)2.35119048
61Abnormality of midbrain morphology (HP:0002418)2.35119048
62Fetal akinesia sequence (HP:0001989)2.34569871
63Anxiety (HP:0000739)2.31170156
64Abnormality of the labia minora (HP:0012880)2.31079765
65Dysmetria (HP:0001310)2.30774024
66Hypsarrhythmia (HP:0002521)2.29816628
67Abnormality of salivation (HP:0100755)2.29801777
68Pancreatic cysts (HP:0001737)2.28376041
69Specific learning disability (HP:0001328)2.27593075
70Genetic anticipation (HP:0003743)2.24903153
71Vitreoretinal degeneration (HP:0000655)2.21724440
72Optic nerve hypoplasia (HP:0000609)2.19062183
73Lissencephaly (HP:0001339)2.19042950
74Inappropriate behavior (HP:0000719)2.18154652
75Spastic tetraplegia (HP:0002510)2.17428589
76Papilledema (HP:0001085)2.17380478
77Pheochromocytoma (HP:0002666)2.17003561
78Volvulus (HP:0002580)2.13791738
79Abnormality of the lower motor neuron (HP:0002366)2.11943913
80Type II lissencephaly (HP:0007260)2.11625234
81Blue irides (HP:0000635)2.10402705
82Agitation (HP:0000713)2.09880034
83Hypothermia (HP:0002045)2.08702100
84Torticollis (HP:0000473)2.07812332
85Stereotypic behavior (HP:0000733)2.07175326
86Neurofibrillary tangles (HP:0002185)2.06297858
87Abnormality of the renal medulla (HP:0100957)2.06035016
88Sleep apnea (HP:0010535)2.03387043
89Poor coordination (HP:0002370)2.01927741
90Impaired smooth pursuit (HP:0007772)2.01364911
91Hypoventilation (HP:0002791)1.99483871
92Esotropia (HP:0000565)1.97621754
93Lower limb muscle weakness (HP:0007340)1.96352809
94Scanning speech (HP:0002168)1.95881830
95Akinesia (HP:0002304)1.94392366
96Cerebral inclusion bodies (HP:0100314)1.93228510
97Focal dystonia (HP:0004373)1.93019035
98Aqueductal stenosis (HP:0002410)1.92556383
99Abnormality of binocular vision (HP:0011514)1.90127269
100Diplopia (HP:0000651)1.90127269
101Degeneration of the lateral corticospinal tracts (HP:0002314)1.89571219
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89571219
103Chronic hepatic failure (HP:0100626)1.89208671
104Fair hair (HP:0002286)1.86983188
105Autism (HP:0000717)1.86698122
106Narrow forehead (HP:0000341)1.86391651
107Cutaneous finger syndactyly (HP:0010554)1.86304154
108Narrow nasal bridge (HP:0000446)1.85258707
109Neuroendocrine neoplasm (HP:0100634)1.85141568
110Postaxial hand polydactyly (HP:0001162)1.85130283
111Shoulder girdle muscle weakness (HP:0003547)1.84678004
112Sporadic (HP:0003745)1.83152452
113Tented upper lip vermilion (HP:0010804)1.82942660
114Megalencephaly (HP:0001355)1.82690719
115Retinal dysplasia (HP:0007973)1.81373498
116Muscular hypotonia of the trunk (HP:0008936)1.81195719
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80543814
118Generalized hypopigmentation of hair (HP:0011358)1.78892308
119Poor suck (HP:0002033)1.78826190
120Postural instability (HP:0002172)1.78527549
121Intellectual disability, severe (HP:0010864)1.77840230
122Morphological abnormality of the pyramidal tract (HP:0002062)1.77225119
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77022846
124Abnormality of ocular smooth pursuit (HP:0000617)1.77017565
125Status epilepticus (HP:0002133)1.76890226
126Papillary thyroid carcinoma (HP:0002895)1.76416033
127Medial flaring of the eyebrow (HP:0010747)1.76206439
128Absent/shortened dynein arms (HP:0200106)1.75663746
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.75663746
130Bradykinesia (HP:0002067)1.75547179
131Pendular nystagmus (HP:0012043)1.75546467
132Congenital primary aphakia (HP:0007707)1.74887936
133Abnormal ciliary motility (HP:0012262)1.73221934
134Intestinal atresia (HP:0011100)1.72936935
135Oligodactyly (hands) (HP:0001180)1.71149283
136Micropenis (HP:0000054)1.67346588
137Hypoplasia of the corpus callosum (HP:0002079)1.66995640
138Colon cancer (HP:0003003)1.66542170
139Renal hypoplasia (HP:0000089)1.65747468
140Decreased testicular size (HP:0008734)1.62270096
141Ulnar claw (HP:0001178)1.61343132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.39633612
2NTRK33.86304246
3EPHA43.16249704
4MAP3K43.09212124
5CASK3.03033290
6MAP3K92.92923296
7MAP2K72.84116259
8NTRK22.79519966
9MINK12.60798457
10MAPK132.22681441
11SIK32.21885477
12FRK2.16913378
13KSR12.15543475
14MAP3K122.04622739
15DAPK21.94717055
16PAK61.82415436
17PNCK1.81277213
18SIK21.76014128
19MAP4K21.70670228
20TNIK1.68993142
21MAP2K41.68488384
22BCR1.67357784
23UHMK11.60889892
24DYRK21.48595653
25CDK191.46963702
26CDK51.43364690
27DAPK11.42616141
28PINK11.38051166
29ERBB31.30289633
30EPHA31.28368997
31PHKG21.19067722
32PHKG11.19067722
33TRIM281.14725623
34PLK21.14558531
35NTRK11.13451303
36PRKCG1.10069788
37GRK51.08188107
38CSNK1G21.07852221
39PRPF4B1.07535918
40WNK31.06895992
41KSR21.05532564
42DYRK31.05194991
43TYRO31.04028132
44CDK181.00657518
45LATS20.95405097
46MKNK20.94666712
47CAMKK10.93948338
48DYRK1A0.92905355
49FGFR20.92738709
50CAMK2A0.92557857
51OXSR10.92319224
52CAMK2B0.90640674
53LIMK10.89787770
54CDK150.88752828
55CDK140.86873689
56RIPK40.86508851
57SGK2230.86361953
58SGK4940.86361953
59FES0.77610010
60PAK30.77551773
61CDK11A0.77257903
62PKN10.72753221
63CSNK1G30.72444328
64INSRR0.71437760
65STK110.71098300
66MARK20.68564227
67ARAF0.65807356
68CCNB10.65647383
69SGK20.61615234
70PRKD30.60444866
71BMPR1B0.60351281
72PRKCE0.59909280
73CSNK1A1L0.59649503
74PRKCZ0.58263894
75FGR0.58086716
76NME10.56503112
77CAMKK20.56109565
78RET0.55276600
79CAMK10.54844209
80SGK10.53718535
81CAMK1G0.53499475
82MAP3K60.51966802
83NEK10.51145323
84YES10.49511117
85GRK10.48538029
86EPHB20.48311195
87RPS6KA20.46437419
88RPS6KA40.44720193
89TAOK10.44718654
90STK390.44691516
91IRAK20.44371665
92STK38L0.43945544
93STK380.43922902
94PRKACB0.43247290
95MAP3K20.43184874
96DYRK1B0.42394006
97CSNK1D0.42363861
98SGK30.41973567
99CDC42BPA0.41809256
100ICK0.40887795
101PRKACA0.40386271
102MKNK10.40374369
103FYN0.40020638
104ROCK20.38415285
105RPS6KA30.38204615
106RAF10.38090427
107MAPK150.37974338
108CSNK1G10.37830968
109NEK60.37283919
110CAMK2D0.37269664
111AKT30.37267185
112FER0.36625496
113WNK40.35876681
114ADRBK10.35094403
115BMPR20.34961926
116CSNK1E0.34684435
117MAPK100.33490722
118CAMK40.32761098
119ROCK10.32585532
120CSNK1A10.32290557
121PRKG10.32264394
122MAPK90.31864564
123ADRBK20.30759629
124PRKCB0.30735930
125CDK30.28849723
126ERBB20.27672449
127GSK3B0.23155398

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.32212594
2Synaptic vesicle cycle_Homo sapiens_hsa047213.28718665
3GABAergic synapse_Homo sapiens_hsa047272.86222763
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84839366
5Circadian entrainment_Homo sapiens_hsa047132.64745332
6Glutamatergic synapse_Homo sapiens_hsa047242.63141630
7Morphine addiction_Homo sapiens_hsa050322.58113190
8Olfactory transduction_Homo sapiens_hsa047402.49110150
9Long-term potentiation_Homo sapiens_hsa047202.30458744
10Amphetamine addiction_Homo sapiens_hsa050312.28255221
11Dopaminergic synapse_Homo sapiens_hsa047282.27173128
12Taste transduction_Homo sapiens_hsa047421.96180418
13Serotonergic synapse_Homo sapiens_hsa047261.93873571
14Salivary secretion_Homo sapiens_hsa049701.89542619
15Cholinergic synapse_Homo sapiens_hsa047251.87976829
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87822856
17Insulin secretion_Homo sapiens_hsa049111.80878880
18Axon guidance_Homo sapiens_hsa043601.80082276
19Cocaine addiction_Homo sapiens_hsa050301.79724262
20Collecting duct acid secretion_Homo sapiens_hsa049661.71128680
21Long-term depression_Homo sapiens_hsa047301.68662758
22Renin secretion_Homo sapiens_hsa049241.64933112
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57030917
24Oxytocin signaling pathway_Homo sapiens_hsa049211.56489638
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55621032
26Gastric acid secretion_Homo sapiens_hsa049711.50163434
27Gap junction_Homo sapiens_hsa045401.47751830
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47580920
29Calcium signaling pathway_Homo sapiens_hsa040201.43432925
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38483947
31Phototransduction_Homo sapiens_hsa047441.36778467
32Cardiac muscle contraction_Homo sapiens_hsa042601.32946206
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26945078
34GnRH signaling pathway_Homo sapiens_hsa049121.26492668
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24030087
36ErbB signaling pathway_Homo sapiens_hsa040121.22440471
37Vibrio cholerae infection_Homo sapiens_hsa051101.12582776
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11632732
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.10472429
40cAMP signaling pathway_Homo sapiens_hsa040241.09213695
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07271055
42Type II diabetes mellitus_Homo sapiens_hsa049301.02721901
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02499986
44Melanogenesis_Homo sapiens_hsa049161.01080275
45Estrogen signaling pathway_Homo sapiens_hsa049150.98911558
46Protein export_Homo sapiens_hsa030600.96136726
47Oxidative phosphorylation_Homo sapiens_hsa001900.95823757
48Glioma_Homo sapiens_hsa052140.93861228
49Oocyte meiosis_Homo sapiens_hsa041140.91620569
50Basal cell carcinoma_Homo sapiens_hsa052170.90433452
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89420493
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88537507
53Alzheimers disease_Homo sapiens_hsa050100.88276812
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86576852
55Alcoholism_Homo sapiens_hsa050340.85163647
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83325027
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81303174
58Hippo signaling pathway_Homo sapiens_hsa043900.79330212
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.76831912
60Parkinsons disease_Homo sapiens_hsa050120.76236595
61MAPK signaling pathway_Homo sapiens_hsa040100.71799233
62Steroid biosynthesis_Homo sapiens_hsa001000.71585165
63Choline metabolism in cancer_Homo sapiens_hsa052310.70012713
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.69948759
65Ether lipid metabolism_Homo sapiens_hsa005650.68278418
66Dilated cardiomyopathy_Homo sapiens_hsa054140.66971609
67Ras signaling pathway_Homo sapiens_hsa040140.66192035
68Wnt signaling pathway_Homo sapiens_hsa043100.65209588
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64923172
70Renal cell carcinoma_Homo sapiens_hsa052110.64464655
71Dorso-ventral axis formation_Homo sapiens_hsa043200.63819013
72Endometrial cancer_Homo sapiens_hsa052130.62743069
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62635031
74Nitrogen metabolism_Homo sapiens_hsa009100.61875711
75Circadian rhythm_Homo sapiens_hsa047100.61037918
76Colorectal cancer_Homo sapiens_hsa052100.59918633
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58850719
78Ovarian steroidogenesis_Homo sapiens_hsa049130.58769029
79Huntingtons disease_Homo sapiens_hsa050160.58748076
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57846144
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57700788
82Pancreatic secretion_Homo sapiens_hsa049720.56835717
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55339319
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54768830
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54598775
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53223021
87Basal transcription factors_Homo sapiens_hsa030220.52156432
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.51951190
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51517894
90Regulation of autophagy_Homo sapiens_hsa041400.51453274
91VEGF signaling pathway_Homo sapiens_hsa043700.51426724
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49160779
93Linoleic acid metabolism_Homo sapiens_hsa005910.48709312
94Rap1 signaling pathway_Homo sapiens_hsa040150.48279433
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48180691
96Thyroid hormone synthesis_Homo sapiens_hsa049180.47877885
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.47204148
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46936161
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45931941
100Type I diabetes mellitus_Homo sapiens_hsa049400.45322708
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45167522
102Hedgehog signaling pathway_Homo sapiens_hsa043400.44251138
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42934330
104Endocytosis_Homo sapiens_hsa041440.39332203
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38835898
106Bile secretion_Homo sapiens_hsa049760.38134119
107Phagosome_Homo sapiens_hsa041450.37359857
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36929922
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36929396
110beta-Alanine metabolism_Homo sapiens_hsa004100.36851329
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36509781
112Tight junction_Homo sapiens_hsa045300.35217668
113Glucagon signaling pathway_Homo sapiens_hsa049220.34403727
114Prion diseases_Homo sapiens_hsa050200.33978345
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33925191
116mTOR signaling pathway_Homo sapiens_hsa041500.33563579
117Insulin signaling pathway_Homo sapiens_hsa049100.32449144
118Propanoate metabolism_Homo sapiens_hsa006400.32188312
119Non-small cell lung cancer_Homo sapiens_hsa052230.32169541
120Butanoate metabolism_Homo sapiens_hsa006500.31991198
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30916695
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29961484
123Inositol phosphate metabolism_Homo sapiens_hsa005620.29615696

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