CSRNP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelial cell chemotaxis (GO:0035767)6.76969424
2regulation of gamma-delta T cell differentiation (GO:0045586)6.30593138
3regulation of gamma-delta T cell activation (GO:0046643)5.95491435
4NIK/NF-kappaB signaling (GO:0038061)5.81511093
5regulation of interleukin-12 biosynthetic process (GO:0045075)5.51635743
6positive thymic T cell selection (GO:0045059)5.21768839
7positive regulation of gamma-delta T cell activation (GO:0046645)5.20138510
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85649858
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.85649858
10response to peptidoglycan (GO:0032494)4.74411532
11antigen processing and presentation of endogenous antigen (GO:0019883)4.66126263
12response to muramyl dipeptide (GO:0032495)4.52564804
13thymic T cell selection (GO:0045061)4.50740745
14JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.39828851
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.30175488
16positive T cell selection (GO:0043368)4.21435461
17negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.10484724
18T cell selection (GO:0045058)4.04635517
19cell migration involved in sprouting angiogenesis (GO:0002042)3.97080991
20negative thymic T cell selection (GO:0045060)3.90986557
21myeloid dendritic cell differentiation (GO:0043011)3.85142907
22negative T cell selection (GO:0043383)3.82232560
23T cell migration (GO:0072678)3.79554208
24positive regulation by symbiont of host defense response (GO:0052509)3.75933308
25modulation by symbiont of host defense response (GO:0052031)3.75933308
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75933308
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75933308
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.75933308
29modulation by symbiont of host immune response (GO:0052553)3.75933308
30macrophage activation involved in immune response (GO:0002281)3.67549895
31interferon-gamma production (GO:0032609)3.65802800
32neutrophil activation involved in immune response (GO:0002283)3.65753781
33tolerance induction (GO:0002507)3.65135822
34response to interleukin-15 (GO:0070672)3.61964676
35detection of other organism (GO:0098543)3.61365197
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58165049
37myeloid dendritic cell activation (GO:0001773)3.54730947
38cellular extravasation (GO:0045123)3.50700807
39positive regulation of interleukin-2 production (GO:0032743)3.40727214
40regulation of response to interferon-gamma (GO:0060330)3.39891744
41detection of bacterium (GO:0016045)3.39208018
42cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.37036399
43lipopolysaccharide-mediated signaling pathway (GO:0031663)3.36241765
44regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.35252482
45regulation of T-helper 2 cell differentiation (GO:0045628)3.34759106
46regulation of T cell tolerance induction (GO:0002664)3.32561818
47regulation of T-helper 1 cell differentiation (GO:0045625)3.30360385
48leukocyte aggregation (GO:0070486)3.28751302
49defense response to protozoan (GO:0042832)3.22356245
50response to protozoan (GO:0001562)3.21044037
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18234827
52regulation of interferon-beta biosynthetic process (GO:0045357)3.17857774
53positive regulation of type 2 immune response (GO:0002830)3.13677088
54negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.13193250
55natural killer cell differentiation (GO:0001779)3.12264086
56regulation of vitamin D biosynthetic process (GO:0060556)3.09948403
57negative regulation of erythrocyte differentiation (GO:0045647)3.07316057
58T cell receptor signaling pathway (GO:0050852)3.04233178
59negative regulation of interleukin-6 production (GO:0032715)3.03581769
60granulocyte activation (GO:0036230)3.00808345
61regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00660367
62neutrophil activation (GO:0042119)2.99265812
63mature B cell differentiation (GO:0002335)2.98849727
64regulation of interleukin-8 biosynthetic process (GO:0045414)2.98653651
65germinal center formation (GO:0002467)2.97896766
66detection of molecule of bacterial origin (GO:0032490)2.97812575
67CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.97451553
68T-helper cell differentiation (GO:0042093)2.97451553
69negative regulation of cytokine production involved in immune response (GO:0002719)2.96578022
70positive regulation of p38MAPK cascade (GO:1900745)2.95426233
71cellular response to interleukin-15 (GO:0071350)2.95298271
72response to laminar fluid shear stress (GO:0034616)2.95181043
73detection of external biotic stimulus (GO:0098581)2.94829142
74response to type I interferon (GO:0034340)2.94411584
75regulation of interleukin-2 biosynthetic process (GO:0045076)2.94039196
76positive regulation of humoral immune response (GO:0002922)2.93567956
77T-helper 1 type immune response (GO:0042088)2.92883320
78macrophage activation (GO:0042116)2.92440850
79blood vessel endothelial cell migration (GO:0043534)2.92246845
80type I interferon signaling pathway (GO:0060337)2.91466636
81cellular response to type I interferon (GO:0071357)2.91466636
82regulation of p38MAPK cascade (GO:1900744)2.90077389
83interferon-gamma-mediated signaling pathway (GO:0060333)2.88759955
84detection of biotic stimulus (GO:0009595)2.87409053
85negative regulation of interleukin-8 production (GO:0032717)2.85202359
86interferon-gamma secretion (GO:0072643)2.81798432
87tyrosine phosphorylation of STAT protein (GO:0007260)2.80577877
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80140205
89negative regulation of T-helper cell differentiation (GO:0045623)2.80140205
90positive regulation of interleukin-12 production (GO:0032735)2.79567666
91negative regulation of T cell mediated immunity (GO:0002710)2.79051348
92myeloid cell activation involved in immune response (GO:0002275)2.76827194
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76752220
94regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.75517030
95positive regulation of B cell differentiation (GO:0045579)2.75363074
96neutrophil mediated immunity (GO:0002446)2.75213421
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.75114390
98antigen receptor-mediated signaling pathway (GO:0050851)2.72719497
99dendritic cell differentiation (GO:0097028)2.71787391
100leukocyte cell-cell adhesion (GO:0007159)2.70877361
101regulation of mast cell degranulation (GO:0043304)2.70374465
102regulation of antigen processing and presentation (GO:0002577)2.69539363
103regulation of interferon-alpha production (GO:0032647)2.69439422
104regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.69129927
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68988886
106regulation of type 2 immune response (GO:0002828)2.68177394
107mature B cell differentiation involved in immune response (GO:0002313)2.67612743
108regulation of chronic inflammatory response (GO:0002676)2.67477234
109embryonic process involved in female pregnancy (GO:0060136)2.67323766
110positive regulation of tolerance induction (GO:0002645)2.66445995
111regulation of germinal center formation (GO:0002634)2.65826512
112activation of MAPKKK activity (GO:0000185)2.64863702
113negative regulation of lymphocyte mediated immunity (GO:0002707)2.64269127
114growth hormone receptor signaling pathway (GO:0060396)2.63853119
115negative regulation of innate immune response (GO:0045824)2.63264362
116response to host immune response (GO:0052572)2.63155096
117response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.63155096
118positive regulation of T cell differentiation in thymus (GO:0033089)2.62795384
119lymphocyte homeostasis (GO:0002260)2.62213912
120regulation of interleukin-12 production (GO:0032655)2.62065955
121regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.61418524
122regulation of B cell receptor signaling pathway (GO:0050855)2.61335855
123JAK-STAT cascade (GO:0007259)2.61089457
124T cell differentiation involved in immune response (GO:0002292)2.60646682
125alpha-beta T cell differentiation involved in immune response (GO:0002293)2.60646682
126alpha-beta T cell activation involved in immune response (GO:0002287)2.60646682
127regulation of interleukin-2 production (GO:0032663)2.59779518
128regulation of T-helper cell differentiation (GO:0045622)2.59049497
129positive regulation of interferon-alpha production (GO:0032727)2.58292423
130regulation of B cell differentiation (GO:0045577)2.57882863
131positive regulation of T cell differentiation (GO:0045582)2.57546425
132regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57427320
133regulation of chemokine biosynthetic process (GO:0045073)2.56740191
134modulation by symbiont of host cellular process (GO:0044068)2.56167546
135positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.55760721
136negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55144761
137alpha-beta T cell differentiation (GO:0046632)2.54950765
138alpha-beta T cell activation (GO:0046631)2.54756125
139regulation of dendritic cell antigen processing and presentation (GO:0002604)2.54167773
140positive regulation of antigen processing and presentation (GO:0002579)2.54023865
141natural killer cell activation (GO:0030101)2.53442629
142positive regulation of chemokine biosynthetic process (GO:0045080)2.53289260
143regulation of T cell receptor signaling pathway (GO:0050856)2.53236936
144response to host defenses (GO:0052200)2.53230967
145regulation of regulatory T cell differentiation (GO:0045589)2.53170813
146regulation of alpha-beta T cell proliferation (GO:0046640)2.52813833
147negative regulation of cell killing (GO:0031342)2.52272170
148negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.52272170
149immunoglobulin mediated immune response (GO:0016064)2.51879795
150establishment of endothelial barrier (GO:0061028)2.51755991
151regulation of thymocyte apoptotic process (GO:0070243)2.51506031
152interleukin-1-mediated signaling pathway (GO:0070498)2.51203111
153regulation of tolerance induction (GO:0002643)2.50656620
154negative regulation of interleukin-12 production (GO:0032695)2.50087054
155positive regulation of cytokine biosynthetic process (GO:0042108)2.49300357
156lymphocyte migration (GO:0072676)2.47077016
157B cell receptor signaling pathway (GO:0050853)2.46730963
158antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45464227
159T cell differentiation (GO:0030217)2.45064701
160T cell costimulation (GO:0031295)2.44198130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.35156418
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.10517970
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.64466932
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.17854501
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.52158090
6* MYC_22102868_ChIP-Seq_BL_Human3.28269030
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.10313383
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.03194103
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.86612686
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.81810192
11* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.79130480
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.77400582
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.60422079
14RUNX_20019798_ChIP-Seq_JUKART_Human2.58436657
15* MAF_26560356_Chip-Seq_TH1_Human2.49338585
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41047160
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39676992
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38507339
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37424936
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34655255
21MYB_26560356_Chip-Seq_TH2_Human2.33890495
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29665735
23VDR_21846776_ChIP-Seq_THP-1_Human2.29623174
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.20776608
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.19043056
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18975747
27MYB_26560356_Chip-Seq_TH1_Human2.18144993
28IRF8_21731497_ChIP-ChIP_J774_Mouse2.14778118
29SCL_19346495_ChIP-Seq_HPC-7_Human2.14544788
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12884133
31KDM2B_26808549_Chip-Seq_DND41_Human2.12060638
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08968804
33* IRF8_27001747_Chip-Seq_BMDM_Mouse2.04527952
34* ELK3_25401928_ChIP-Seq_HUVEC_Human2.01081265
35VDR_24763502_ChIP-Seq_THP-1_Human1.95911917
36* UTX_26944678_Chip-Seq_JUKART_Human1.94713494
37CLOCK_20551151_ChIP-Seq_293T_Human1.93981799
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85848597
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82538191
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82160061
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65611291
42* RUNX1_22412390_ChIP-Seq_EML_Mouse1.65285623
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64042450
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60447230
45MAF_26560356_Chip-Seq_TH2_Human1.57965908
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51941318
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.48677718
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43684067
49* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40519496
50GATA3_27048872_Chip-Seq_THYMUS_Human1.34937648
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34267447
52ZNF263_19887448_ChIP-Seq_K562_Human1.30070817
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25858397
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24890697
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23494574
56SPI1_23547873_ChIP-Seq_NB4_Human1.23444625
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.20948783
58SPI1_23127762_ChIP-Seq_K562_Human1.20727298
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.20724459
60RACK7_27058665_Chip-Seq_MCF-7_Human1.20103237
61GATA1_22025678_ChIP-Seq_K562_Human1.18403446
62* NCOR1_26117541_ChIP-Seq_K562_Human1.17798121
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17404018
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17346034
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17246693
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15493252
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.14814757
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12961726
69* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12538946
70* ESR1_21235772_ChIP-Seq_MCF-7_Human1.12110386
71* ATF3_27146783_Chip-Seq_COLON_Human1.11097505
72* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10600114
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09909327
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09282181
75* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09119146
76* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08660870
77* ESR2_21235772_ChIP-Seq_MCF-7_Human1.08609175
78E2F7_22180533_ChIP-Seq_HELA_Human1.07833967
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07769728
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06319157
81* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04866329
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04280354
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04056870
84PU_27001747_Chip-Seq_BMDM_Mouse1.03946273
85VDR_24787735_ChIP-Seq_THP-1_Human1.03300860
86GATA1_19941826_ChIP-Seq_K562_Human1.01616518
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01375940
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01375940
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00044179
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99921974
91* RUNX1_27514584_Chip-Seq_MCF-7_Human0.99886962
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99587150
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99507208
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97961927
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97679004
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97501599
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97424096
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96494610
99KDM2B_26808549_Chip-Seq_K562_Human0.95545889
100GATA2_19941826_ChIP-Seq_K562_Human0.94058623
101GATA2_21666600_ChIP-Seq_HMVEC_Human0.92649649
102* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92548382
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91893335
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91893335
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91893335
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91691026
107CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91436152
108GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90856970
109* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90588400
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90062844
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89843541
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89144893
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89135251
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88710290
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88283216
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87532580
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86963656
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86190394
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85451754
120RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83179474
121* LXR_22292898_ChIP-Seq_THP-1_Human0.82806596
122* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82515926
123FOXM1_23109430_ChIP-Seq_U2OS_Human0.82379393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis3.81361906
2MP0003303_peritoneal_inflammation3.54981079
3MP0000685_abnormal_immune_system3.20624233
4MP0003436_decreased_susceptibility_to3.16105092
5MP0003763_abnormal_thymus_physiology3.16048956
6MP0001790_abnormal_immune_system2.79207300
7MP0005387_immune_system_phenotype2.79207300
8MP0003724_increased_susceptibility_to2.74633163
9MP0001800_abnormal_humoral_immune2.73535111
10MP0001835_abnormal_antigen_presentation2.68713808
11MP0005000_abnormal_immune_tolerance2.62147495
12MP0002138_abnormal_hepatobiliary_system2.42454481
13MP0004947_skin_inflammation2.39969047
14MP0002452_abnormal_antigen_presenting2.38920906
15MP0009278_abnormal_bone_marrow2.38808224
16MP0001853_heart_inflammation2.37531269
17MP0002723_abnormal_immune_serum2.36946748
18MP0002405_respiratory_system_inflammati2.36221496
19MP0003300_gastrointestinal_ulcer2.31618028
20MP0005671_abnormal_response_to2.18852764
21MP0002420_abnormal_adaptive_immunity2.17151755
22MP0001819_abnormal_immune_cell2.15997964
23MP0004808_abnormal_hematopoietic_stem2.13964643
24MP0009785_altered_susceptibility_to2.07799065
25MP0010155_abnormal_intestine_physiology2.04972454
26MP0002398_abnormal_bone_marrow2.01741722
27MP0010352_gastrointestinal_tract_polyps1.96740788
28MP0008004_abnormal_stomach_pH1.96231842
29MP0002166_altered_tumor_susceptibility1.93163613
30MP0002419_abnormal_innate_immunity1.93020671
31MP0001851_eye_inflammation1.92421415
32MP0005025_abnormal_response_to1.90604855
33MP0001873_stomach_inflammation1.89320325
34MP0002148_abnormal_hypersensitivity_rea1.88383419
35MP0000716_abnormal_immune_system1.82459733
36MP0002254_reproductive_system_inflammat1.82113979
37MP0000703_abnormal_thymus_morphology1.76728373
38MP0005076_abnormal_cell_differentiation1.67920782
39MP0000689_abnormal_spleen_morphology1.66642713
40MP0002722_abnormal_immune_system1.66537033
41MP0001533_abnormal_skeleton_physiology1.65135121
42MP0001545_abnormal_hematopoietic_system1.63960120
43MP0005397_hematopoietic_system_phenotyp1.63960120
44MP0002006_tumorigenesis1.61233278
45MP0002933_joint_inflammation1.60109296
46MP0003866_abnormal_defecation1.58727630
47MP0001845_abnormal_inflammatory_respons1.58183474
48MP0009333_abnormal_splenocyte_physiolog1.57920061
49MP0005058_abnormal_lysosome_morphology1.57864266
50MP0003828_pulmonary_edema1.57765553
51MP0005451_abnormal_body_composition1.56281044
52MP0002396_abnormal_hematopoietic_system1.54474226
53MP0006082_CNS_inflammation1.52256910
54MP0003172_abnormal_lysosome_physiology1.50130819
55MP0002429_abnormal_blood_cell1.48721592
56MP0005310_abnormal_salivary_gland1.47381406
57MP0005464_abnormal_platelet_physiology1.45475767
58MP0008961_abnormal_basal_metabolism1.40666905
59MP0003453_abnormal_keratinocyte_physiol1.37442814
60MP0000465_gastrointestinal_hemorrhage1.36358182
61MP0003448_altered_tumor_morphology1.36164288
62MP0003566_abnormal_cell_adhesion1.30638064
63MP0003656_abnormal_erythrocyte_physiolo1.29011906
64MP0002998_abnormal_bone_remodeling1.26504171
65MP0005023_abnormal_wound_healing1.21959181
66MP0002132_abnormal_respiratory_system1.18600538
67MP0002332_abnormal_exercise_endurance1.17213052
68MP0003091_abnormal_cell_migration1.15689467
69MP0009840_abnormal_foam_cell1.13285289
70MP0008260_abnormal_autophagy1.11909128
71MP0000490_abnormal_crypts_of1.07474336
72MP0000858_altered_metastatic_potential1.07066538
73MP0010307_abnormal_tumor_latency1.03149913
74MP0003705_abnormal_hypodermis_morpholog1.02875599
75MP0001348_abnormal_lacrimal_gland0.98608619
76MP0002009_preneoplasia0.98490748
77MP0000249_abnormal_blood_vessel0.96712479
78MP0002877_abnormal_melanocyte_morpholog0.96157727
79MP0008469_abnormal_protein_level0.94249663
80MP0001501_abnormal_sleep_pattern0.91866138
81* MP0005390_skeleton_phenotype0.89634749
82MP0001216_abnormal_epidermal_layer0.87809904
83MP0000604_amyloidosis0.86975026
84MP0003191_abnormal_cellular_cholesterol0.85924393
85MP0000733_abnormal_muscle_development0.80071169
86MP0009765_abnormal_xenobiotic_induced0.79776821
87MP0002277_abnormal_respiratory_mucosa0.79154119
88MP0001243_abnormal_dermal_layer0.79130246
89MP0010368_abnormal_lymphatic_system0.77490447
90MP0003075_altered_response_to0.77229303
91MP0001879_abnormal_lymphatic_vessel0.76406884
92MP0002019_abnormal_tumor_incidence0.75968633
93MP0005166_decreased_susceptibility_to0.75651615
94MP0005167_abnormal_blood-brain_barrier0.74998549
95MP0003795_abnormal_bone_structure0.74438722
96MP0000609_abnormal_liver_physiology0.72866203
97MP0004381_abnormal_hair_follicle0.72640902
98MP0005666_abnormal_adipose_tissue0.71508155
99MP0003045_fibrosis0.71035693
100MP0003690_abnormal_glial_cell0.70821949
101MP0000343_altered_response_to0.70311228
102MP0002060_abnormal_skin_morphology0.69591277
103MP0001663_abnormal_digestive_system0.68698733
104MP0001542_abnormal_bone_strength0.68206501
105MP0000767_abnormal_smooth_muscle0.67351108
106MP0008995_early_reproductive_senescence0.67350987
107MP0008057_abnormal_DNA_replication0.65288992
108MP0009764_decreased_sensitivity_to0.64679656
109MP0004883_abnormal_blood_vessel0.64638494
110MP0005165_increased_susceptibility_to0.64460063
111MP0001191_abnormal_skin_condition0.63653297
112MP0005535_abnormal_body_temperature0.62237833
113MP0009931_abnormal_skin_appearance0.61705507
114MP0002136_abnormal_kidney_physiology0.61527477
115MP0009115_abnormal_fat_cell0.60776498
116MP0009763_increased_sensitivity_to0.58010518
117MP0003279_aneurysm0.57420906
118MP0008007_abnormal_cellular_replicative0.56554817
119MP0005164_abnormal_response_to0.56073128

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.11662113
2Eczematoid dermatitis (HP:0000976)4.55150184
3Elevated erythrocyte sedimentation rate (HP:0003565)4.53012484
4Abnormality of the nasal mucosa (HP:0000433)4.20120124
5Nasal polyposis (HP:0100582)4.15427713
6Myositis (HP:0100614)4.05581110
7Recurrent fungal infections (HP:0002841)3.82801892
8Recurrent bronchitis (HP:0002837)3.66129421
9Orchitis (HP:0100796)3.63180197
10Chronic otitis media (HP:0000389)3.61058452
11Cellulitis (HP:0100658)3.56918498
12Persistence of primary teeth (HP:0006335)3.56573184
13Increased density of long bones (HP:0006392)3.44578750
14Retrobulbar optic neuritis (HP:0100654)3.40311623
15Optic neuritis (HP:0100653)3.40311623
16Recurrent viral infections (HP:0004429)3.36499666
17Spontaneous hematomas (HP:0007420)3.32964105
18IgM deficiency (HP:0002850)3.30004919
19Panhypogammaglobulinemia (HP:0003139)3.14489402
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.13226040
21Abnormality of T cell number (HP:0011839)3.09026618
22T lymphocytopenia (HP:0005403)3.08694681
23Abnormality of the fingertips (HP:0001211)3.05350271
24Increased IgE level (HP:0003212)3.04132304
25Pustule (HP:0200039)3.03013466
26Hematochezia (HP:0002573)2.96475727
27Vasculitis (HP:0002633)2.96305165
28Amyloidosis (HP:0011034)2.92866830
29Myocardial infarction (HP:0001658)2.92752392
30Recurrent abscess formation (HP:0002722)2.89373540
31Mediastinal lymphadenopathy (HP:0100721)2.88534166
32Interstitial pulmonary disease (HP:0006530)2.82360536
33Dysostosis multiplex (HP:0000943)2.80269562
34Recurrent bacterial skin infections (HP:0005406)2.79536374
35Arterial thrombosis (HP:0004420)2.79016864
36Emphysema (HP:0002097)2.77838687
37Abnormality of T cells (HP:0002843)2.75183270
38Pulmonary infiltrates (HP:0002113)2.74830790
39Leukocytosis (HP:0001974)2.70806220
40Cerebral aneurysm (HP:0004944)2.70685499
41Eosinophilia (HP:0001880)2.66789510
42Autoimmune hemolytic anemia (HP:0001890)2.65960736
43Recurrent cutaneous fungal infections (HP:0011370)2.60616678
44Chronic mucocutaneous candidiasis (HP:0002728)2.60616678
45Gangrene (HP:0100758)2.60026648
46Severe combined immunodeficiency (HP:0004430)2.59950727
47Chronic obstructive pulmonary disease (HP:0006510)2.59864094
48Abnormality of liposaccharide metabolism (HP:0010968)2.54975790
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.54975790
50Abnormality of glycolipid metabolism (HP:0010969)2.54975790
51Encephalitis (HP:0002383)2.54894523
52Episodic fever (HP:0001954)2.54329478
53Abnormality of eosinophils (HP:0001879)2.54027646
54B lymphocytopenia (HP:0010976)2.51270744
55Abnormality of B cell number (HP:0010975)2.51270744
56Autoimmune thrombocytopenia (HP:0001973)2.49921735
57Keratoconjunctivitis sicca (HP:0001097)2.48959803
58Aortic aneurysm (HP:0004942)2.43129259
59Meningitis (HP:0001287)2.42418910
60Abnormality of T cell physiology (HP:0011840)2.41339032
61Combined immunodeficiency (HP:0005387)2.40899113
62Urticaria (HP:0001025)2.40222333
63Hemoptysis (HP:0002105)2.40048744
64Systemic lupus erythematosus (HP:0002725)2.36680540
65Polycythemia (HP:0001901)2.35885117
66Colitis (HP:0002583)2.35646219
67Keratoconjunctivitis (HP:0001096)2.35482001
68Spondylolisthesis (HP:0003302)2.34443852
69Lymphopenia (HP:0001888)2.34308187
70Inflammation of the large intestine (HP:0002037)2.33945244
71Stomach cancer (HP:0012126)2.33808884
72Thrombocytosis (HP:0001894)2.32890759
73Thyroiditis (HP:0100646)2.31536955
74IgG deficiency (HP:0004315)2.30912302
75Recurrent skin infections (HP:0001581)2.30871518
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.30824980
77Segmental peripheral demyelination/remyelination (HP:0003481)2.30560288
78Gastrointestinal inflammation (HP:0004386)2.25775728
79Abnormality of the pleura (HP:0002103)2.25556102
80Agammaglobulinemia (HP:0004432)2.24999240
81Alveolar cell carcinoma (HP:0006519)2.22863655
82Increased cerebral lipofuscin (HP:0011813)2.22340803
83Bronchitis (HP:0012387)2.21557089
84Loss of speech (HP:0002371)2.20825425
85Abnormality of polysaccharide metabolism (HP:0011012)2.18235270
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18235270
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18235270
88Gastrointestinal stroma tumor (HP:0100723)2.18190147
89Glomerulopathy (HP:0100820)2.17542539
90Increased serum ferritin (HP:0003281)2.14488532
91Restrictive lung disease (HP:0002091)2.13854811
92Mucopolysacchariduria (HP:0008155)2.13057816
93Urinary glycosaminoglycan excretion (HP:0003541)2.13057816
94Abnormality of macrophages (HP:0004311)2.12270607
95Epistaxis (HP:0000421)2.10869734
96Granulocytopenia (HP:0001913)2.10636785
97Neoplasm of the tracheobronchial system (HP:0100552)2.10214806
98Papilloma (HP:0012740)2.09420597
99Verrucae (HP:0200043)2.09420597
100Recurrent sinusitis (HP:0011108)2.08180088
101Abnormal platelet function (HP:0011869)2.07754531
102Impaired platelet aggregation (HP:0003540)2.07754531
103Increased CSF protein (HP:0002922)2.07705764
104Gingivitis (HP:0000230)2.07300029
105IgA deficiency (HP:0002720)2.06647584
106Gingival bleeding (HP:0000225)2.05865501
107Pulmonary embolism (HP:0002204)2.05805402
108Joint swelling (HP:0001386)2.05221086
109Gastrointestinal infarctions (HP:0005244)2.03617675
110Mitral valve prolapse (HP:0001634)2.03426328
111Osteolytic defects of the hand bones (HP:0009699)2.01785163
112Osteolytic defects of the phalanges of the hand (HP:0009771)2.01785163
113Esophageal varix (HP:0002040)2.01746856
114Prolonged bleeding time (HP:0003010)2.01029373
115Vertigo (HP:0002321)2.00898454
116Chronic diarrhea (HP:0002028)2.00779440
117Chronic sinusitis (HP:0011109)1.99938221
118Increased IgM level (HP:0003496)1.98077219
119Vacuolated lymphocytes (HP:0001922)1.97092219
120Hypergammaglobulinemia (HP:0010702)1.95520215
121Fatigue (HP:0012378)1.94200799
122Osteomyelitis (HP:0002754)1.94153280
123Recurrent gram-negative bacterial infections (HP:0005420)1.93795067
124Abnormal platelet volume (HP:0011876)1.93626905
125Arthralgia (HP:0002829)1.93388441
126Thick nail (HP:0001805)1.93130477
127Disproportionate tall stature (HP:0001519)1.92679527
128Polyneuropathy (HP:0001271)1.90990053
129Anorexia (HP:0002039)1.90907578
130Skin ulcer (HP:0200042)1.90775562
131Sepsis (HP:0100806)1.89964954
132Obstructive sleep apnea (HP:0002870)1.89430339
133Chest pain (HP:0100749)1.87043156
134Peripheral hypomyelination (HP:0007182)1.86965856
135Lymphoma (HP:0002665)1.85939834
136Abnormality of the pericardium (HP:0001697)1.85720908
137Obstructive lung disease (HP:0006536)1.84822428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.92472683
2PRPF4B3.59680575
3MAP3K143.53485589
4EEF2K3.30801443
5MAP3K103.24570122
6TXK3.08633844
7RIPK42.76203814
8TBK12.49300611
9IKBKB2.45059358
10TGFBR22.35070815
11EPHB12.27697589
12STK102.24024013
13IKBKE2.21443417
14CHUK2.19126715
15JAK32.13745455
16FGFR42.08641953
17TYK22.07921961
18ZAP701.91673262
19EPHA31.90495639
20BMPR21.90122114
21ERN11.85980456
22NLK1.82791119
23PIM11.76822072
24MAP3K31.76303745
25TAOK21.74554288
26RPS6KA41.74046044
27ITK1.67705829
28GRK61.66834974
29TRIB31.66569246
30IRAK21.62823827
31MAP2K31.62374727
32IRAK31.57565878
33JAK11.46343386
34CDK121.43791721
35MAPK151.34626787
36PIM21.34211817
37RPS6KA51.29161154
38FGFR31.28659079
39TSSK61.20709658
40HCK1.15488295
41BTK1.12557890
42MATK1.10405699
43RIPK11.09923282
44MARK31.09444363
45MAP3K111.09430979
46TNK21.07787016
47LCK1.07009632
48MARK21.03903460
49PKN21.02509912
50TEC1.01612205
51TIE11.00373675
52DMPK0.99254343
53CSK0.98384586
54MOS0.98121114
55MST40.95469660
56PTK60.93556623
57TAOK30.93030693
58MAPK120.92850519
59LRRK20.91446046
60GRK70.90702235
61CDC42BPA0.87472899
62JAK20.86941927
63KDR0.85601853
64MAP3K130.82421796
65HIPK20.81869715
66RPS6KA10.81009567
67MAP2K20.79998707
68SYK0.79678748
69CLK10.77643449
70RPS6KL10.75575020
71RPS6KC10.75575020
72TAOK10.75345191
73TGFBR10.74574683
74PDK20.72709923
75PDGFRB0.71425037
76KIT0.69766771
77BMX0.69002382
78GSK3A0.68936968
79PDK10.68144754
80IRAK10.67377980
81BRD40.65932321
82CSF1R0.64343870
83MAPKAPK20.64041445
84IRAK40.63535532
85TTN0.62516840
86NME20.62268825
87TRPM70.60382140
88PDPK10.60238930
89RPS6KA20.60177607
90MELK0.59999710
91BLK0.58965263
92FGR0.57136473
93MAP3K10.56973903
94CDK90.55221588
95MAPK70.53660316
96TESK20.53555704
97SIK10.53481661
98PIK3CG0.52429809
99KSR20.51723727
100ALK0.51286062
101CDK40.48068606
102RPS6KA60.47520659
103PAK20.46995106
104SIK20.46606653
105MTOR0.45650019
106MAP3K70.43150827
107MAPK30.43061339
108EPHA20.42920071
109MAP3K60.42210116
110MAPK40.41940284
111PRKCH0.41603214
112RPS6KB20.40898901
113MAP3K50.40554580
114SIK30.40425133
115SGK30.39125629
116DYRK1B0.35338352
117MAP3K80.35201452
118PRKCQ0.34957767
119PRKD20.33979936
120STK110.33830392
121MAPK110.33629092
122LYN0.32818546
123ICK0.32805192
124CDK60.31977393
125ABL10.31633266
126MAPK10.31248269
127STK240.30863936
128FES0.30838081
129INSR0.30826237
130STK40.30215548
131STK30.28549778

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040643.12276879
2Osteoclast differentiation_Homo sapiens_hsa043803.03094870
3Primary immunodeficiency_Homo sapiens_hsa053402.74694802
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54686066
5Leishmaniasis_Homo sapiens_hsa051402.41622761
6T cell receptor signaling pathway_Homo sapiens_hsa046602.41130020
7B cell receptor signaling pathway_Homo sapiens_hsa046622.32898264
8Measles_Homo sapiens_hsa051622.24534501
9TNF signaling pathway_Homo sapiens_hsa046682.18023154
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.02226929
11Toxoplasmosis_Homo sapiens_hsa051451.98142182
12Other glycan degradation_Homo sapiens_hsa005111.95553228
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94033482
14Acute myeloid leukemia_Homo sapiens_hsa052211.88612557
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.85293829
16Antigen processing and presentation_Homo sapiens_hsa046121.83733935
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71504969
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64911081
19Apoptosis_Homo sapiens_hsa042101.63312176
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61382225
21Legionellosis_Homo sapiens_hsa051341.59800931
22Hepatitis B_Homo sapiens_hsa051611.55475456
23Chronic myeloid leukemia_Homo sapiens_hsa052201.55392998
24Malaria_Homo sapiens_hsa051441.55359831
25Prolactin signaling pathway_Homo sapiens_hsa049171.55179232
26Herpes simplex infection_Homo sapiens_hsa051681.54893369
27Influenza A_Homo sapiens_hsa051641.53432558
28Allograft rejection_Homo sapiens_hsa053301.53267793
29Graft-versus-host disease_Homo sapiens_hsa053321.44567522
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42990534
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42232016
32Small cell lung cancer_Homo sapiens_hsa052221.33072265
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.32996833
34Hematopoietic cell lineage_Homo sapiens_hsa046401.31178564
35HTLV-I infection_Homo sapiens_hsa051661.27850486
36Shigellosis_Homo sapiens_hsa051311.25871376
37Chemokine signaling pathway_Homo sapiens_hsa040621.19754333
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18481764
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18302907
40Pertussis_Homo sapiens_hsa051331.16526129
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15731571
42Hepatitis C_Homo sapiens_hsa051601.14233834
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13271664
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12676896
45Epstein-Barr virus infection_Homo sapiens_hsa051691.11687095
46Pancreatic cancer_Homo sapiens_hsa052121.06223772
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.05948379
48Viral carcinogenesis_Homo sapiens_hsa052031.04801999
49Viral myocarditis_Homo sapiens_hsa054161.01638079
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.01325816
51MAPK signaling pathway_Homo sapiens_hsa040101.00158118
52Staphylococcus aureus infection_Homo sapiens_hsa051500.99911090
53Notch signaling pathway_Homo sapiens_hsa043300.98408852
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.97559544
55VEGF signaling pathway_Homo sapiens_hsa043700.97185950
56Asthma_Homo sapiens_hsa053100.97090409
57Platelet activation_Homo sapiens_hsa046110.96644519
58Tuberculosis_Homo sapiens_hsa051520.96531927
59Insulin resistance_Homo sapiens_hsa049310.95587754
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94794523
61Salmonella infection_Homo sapiens_hsa051320.91493600
62FoxO signaling pathway_Homo sapiens_hsa040680.90628110
63Colorectal cancer_Homo sapiens_hsa052100.87553756
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85739169
65African trypanosomiasis_Homo sapiens_hsa051430.84906868
66MicroRNAs in cancer_Homo sapiens_hsa052060.82772394
67Lysosome_Homo sapiens_hsa041420.80105563
68Rheumatoid arthritis_Homo sapiens_hsa053230.79792451
69Autoimmune thyroid disease_Homo sapiens_hsa053200.79011946
70Type II diabetes mellitus_Homo sapiens_hsa049300.77538255
71Amoebiasis_Homo sapiens_hsa051460.77058913
72Renal cell carcinoma_Homo sapiens_hsa052110.77051493
73Bladder cancer_Homo sapiens_hsa052190.75618381
74Circadian rhythm_Homo sapiens_hsa047100.72491749
75Prostate cancer_Homo sapiens_hsa052150.69895422
76p53 signaling pathway_Homo sapiens_hsa041150.69701225
77Phagosome_Homo sapiens_hsa041450.67607997
78HIF-1 signaling pathway_Homo sapiens_hsa040660.66231782
79Proteoglycans in cancer_Homo sapiens_hsa052050.65998836
80GnRH signaling pathway_Homo sapiens_hsa049120.63145463
81Dorso-ventral axis formation_Homo sapiens_hsa043200.60180173
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59373801
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.59031942
84Prion diseases_Homo sapiens_hsa050200.58487086
85Focal adhesion_Homo sapiens_hsa045100.58408319
86Pathways in cancer_Homo sapiens_hsa052000.56828568
87mTOR signaling pathway_Homo sapiens_hsa041500.54988244
88Choline metabolism in cancer_Homo sapiens_hsa052310.54906529
89ErbB signaling pathway_Homo sapiens_hsa040120.53623729
90Adherens junction_Homo sapiens_hsa045200.51511676
91Non-small cell lung cancer_Homo sapiens_hsa052230.51500233
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51135259
93Type I diabetes mellitus_Homo sapiens_hsa049400.49756633
94Inositol phosphate metabolism_Homo sapiens_hsa005620.49158968
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48843464
96TGF-beta signaling pathway_Homo sapiens_hsa043500.47646653
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47486460
98Endometrial cancer_Homo sapiens_hsa052130.47236927
99Complement and coagulation cascades_Homo sapiens_hsa046100.47038499
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46825463
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43651203
102Endocytosis_Homo sapiens_hsa041440.43469980
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.42701210
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42418480
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41809934
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40830407
107Estrogen signaling pathway_Homo sapiens_hsa049150.38682219
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37867744
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37395561
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37153258
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37072221
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34784002
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34033927

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