CSPG4P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.97846728
2regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.72244977
3regulation of NFAT protein import into nucleus (GO:0051532)4.40668701
4postsynaptic membrane organization (GO:0001941)4.30689286
5limb bud formation (GO:0060174)4.22354868
6positive regulation of catecholamine secretion (GO:0033605)4.16948630
7presynaptic membrane organization (GO:0097090)4.15953057
8coenzyme catabolic process (GO:0009109)4.15886143
9pyrimidine nucleobase catabolic process (GO:0006208)4.12630165
10neuron cell-cell adhesion (GO:0007158)3.72925004
11acrosome reaction (GO:0007340)3.57529469
12glycosphingolipid biosynthetic process (GO:0006688)3.53170941
13mesenchymal-epithelial cell signaling (GO:0060638)3.52050232
14central nervous system projection neuron axonogenesis (GO:0021952)3.50958394
15activation of protein kinase B activity (GO:0032148)3.50206292
16positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47339185
17cytoplasmic mRNA processing body assembly (GO:0033962)3.46557471
18negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.45424296
19positive regulation of action potential (GO:0045760)3.43457098
20epithelial cilium movement (GO:0003351)3.39712377
21DNA double-strand break processing (GO:0000729)3.29196553
22regulation of autophagic vacuole assembly (GO:2000785)3.28646193
23intraciliary transport (GO:0042073)3.27462427
24calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.23469123
25nucleobase catabolic process (GO:0046113)3.23298291
26behavioral response to nicotine (GO:0035095)3.12970136
27dendritic spine morphogenesis (GO:0060997)3.12224515
28central nervous system neuron axonogenesis (GO:0021955)3.06966329
29axonal fasciculation (GO:0007413)3.05994789
30otic vesicle formation (GO:0030916)3.02688412
31protein localization to cell surface (GO:0034394)3.01214579
32oligosaccharide biosynthetic process (GO:0009312)2.98266519
33neuron fate determination (GO:0048664)2.98031891
34motile cilium assembly (GO:0044458)2.97322587
35negative regulation of DNA binding (GO:0043392)2.95008879
36neuron projection extension involved in neuron projection guidance (GO:1902284)2.93157073
37axon extension involved in axon guidance (GO:0048846)2.93157073
38toxin metabolic process (GO:0009404)2.92831488
39multicellular organism reproduction (GO:0032504)2.92092030
40synapse assembly (GO:0007416)2.90497199
41regulation of keratinocyte proliferation (GO:0010837)2.89634904
42response to auditory stimulus (GO:0010996)2.87767075
43cilium movement (GO:0003341)2.87377078
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87080512
45neuron recognition (GO:0008038)2.86633562
46atrial cardiac muscle cell action potential (GO:0086014)2.85240971
47positive regulation of oligodendrocyte differentiation (GO:0048714)2.84824529
48regulation of action potential (GO:0098900)2.82467019
49mRNA cleavage (GO:0006379)2.81228989
50neuromuscular synaptic transmission (GO:0007274)2.80310227
51cellular response to zinc ion (GO:0071294)2.79279997
52cranial nerve morphogenesis (GO:0021602)2.79140131
53retinal ganglion cell axon guidance (GO:0031290)2.77845088
54ADP metabolic process (GO:0046031)2.77483280
55neurofilament cytoskeleton organization (GO:0060052)2.75604629
56regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75552355
57peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.75399214
58negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74628895
59regulation of phosphoprotein phosphatase activity (GO:0043666)2.71816910
60auditory behavior (GO:0031223)2.70566239
61kidney morphogenesis (GO:0060993)2.70102532
62regulation of vacuole organization (GO:0044088)2.69619542
63axonemal dynein complex assembly (GO:0070286)2.69479761
64cell migration in hindbrain (GO:0021535)2.67941140
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67317904
66gamma-aminobutyric acid transport (GO:0015812)2.62106258
67negative regulation of dendrite development (GO:2000171)2.61823714
68positive regulation of amine transport (GO:0051954)2.61480311
69urinary tract smooth muscle contraction (GO:0014848)2.61289271
70dendrite development (GO:0016358)2.60477125
71spinal cord motor neuron differentiation (GO:0021522)2.60318780
72regulation of phospholipase A2 activity (GO:0032429)2.60264697
73DNA integration (GO:0015074)2.59686781
74cilium morphogenesis (GO:0060271)2.57775421
75neurotransmitter-gated ion channel clustering (GO:0072578)2.56427754
76negative regulation of striated muscle cell apoptotic process (GO:0010664)2.55131731
77acrosome assembly (GO:0001675)2.53096617
78muscle fiber development (GO:0048747)2.51327619
79microtubule severing (GO:0051013)2.50116699
80negative regulation of Rho protein signal transduction (GO:0035024)2.45742835
81regulation of acrosome reaction (GO:0060046)2.45728358
82vocalization behavior (GO:0071625)2.44413357
83adult heart development (GO:0007512)2.43285388
84receptor recycling (GO:0001881)2.43084566
85cornea development in camera-type eye (GO:0061303)2.42655235
86tryptophan catabolic process (GO:0006569)2.42032314
87indole-containing compound catabolic process (GO:0042436)2.42032314
88indolalkylamine catabolic process (GO:0046218)2.42032314
89sperm motility (GO:0030317)2.41809357
90cGMP-mediated signaling (GO:0019934)2.41009432
91sialylation (GO:0097503)2.40832858
92regulation of dopamine secretion (GO:0014059)2.39991377
93protein localization to cilium (GO:0061512)2.37982942
94neural tube formation (GO:0001841)2.35803448
95positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.35629478
96regulation of cell maturation (GO:1903429)2.35053901
97protein localization to synapse (GO:0035418)2.35016712
98protein polyglutamylation (GO:0018095)2.34217266
99lateral sprouting from an epithelium (GO:0060601)2.33830879
100positive regulation of synapse assembly (GO:0051965)2.31204578

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.28674975
2GBX2_23144817_ChIP-Seq_PC3_Human4.35936709
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.35344179
4EZH2_22144423_ChIP-Seq_EOC_Human4.20786557
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.92654992
6IGF1R_20145208_ChIP-Seq_DFB_Human3.64758910
7ZNF274_21170338_ChIP-Seq_K562_Hela2.76145551
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48273951
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42728207
10FUS_26573619_Chip-Seq_HEK293_Human2.31386566
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22658591
12P300_19829295_ChIP-Seq_ESCs_Human2.16639473
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16403258
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.07181318
15AR_21572438_ChIP-Seq_LNCaP_Human2.05730041
16VDR_22108803_ChIP-Seq_LS180_Human2.05201304
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91656445
18SMAD4_21799915_ChIP-Seq_A2780_Human1.89704132
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84661829
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80453123
21SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.80317696
22TAF15_26573619_Chip-Seq_HEK293_Human1.78771653
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73505845
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72390571
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72390571
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69106768
27TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65963723
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64633200
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.60749124
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60512567
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.57861288
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56911152
33EWS_26573619_Chip-Seq_HEK293_Human1.55048107
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54733556
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54716138
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52089557
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47807018
38CBP_20019798_ChIP-Seq_JUKART_Human1.47807018
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47621146
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47014928
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.46212056
42ER_23166858_ChIP-Seq_MCF-7_Human1.45254237
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44873688
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44496015
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41006385
46RUNX2_22187159_ChIP-Seq_PCA_Human1.40902033
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39394511
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38760254
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38760254
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38722504
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38148367
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.38028404
53AR_25329375_ChIP-Seq_VCAP_Human1.35740825
54RXR_22108803_ChIP-Seq_LS180_Human1.32089714
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31443358
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31177202
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.29992417
58WDR5_24793694_ChIP-Seq_LNCAP_Human1.29399707
59STAT3_23295773_ChIP-Seq_U87_Human1.28077229
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27845752
61RNF2_27304074_Chip-Seq_NSC_Mouse1.27059794
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25723089
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23903455
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.23022891
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21911424
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21543860
67AHR_22903824_ChIP-Seq_MCF-7_Human1.20545503
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20081071
69REST_21632747_ChIP-Seq_MESCs_Mouse1.19033277
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.17516229
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.17397529
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17177739
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16834534
74DROSHA_22980978_ChIP-Seq_HELA_Human1.15445754
75TCF4_23295773_ChIP-Seq_U87_Human1.15202489
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14902781
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11283474
78TP53_18474530_ChIP-ChIP_U2OS_Human1.11228089
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.10155727
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.09058398
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.08630785
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08399050
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07668817
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.07106886
85BCAT_22108803_ChIP-Seq_LS180_Human1.06547032
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05091165
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03854250
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03047734
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01486846
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00577371
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.00309978
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99143552
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98969419
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95595440
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.93878493
96KDM2B_26808549_Chip-Seq_REH_Human0.92831796
97TBL1_22424771_ChIP-Seq_293T_Human0.92562899
98JUN_21703547_ChIP-Seq_K562_Human0.91070820
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.90143538
100AR_19668381_ChIP-Seq_PC3_Human0.88721242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.81655296
2MP0003880_abnormal_central_pattern3.07384699
3MP0002102_abnormal_ear_morphology2.66471744
4MP0006072_abnormal_retinal_apoptosis2.62403282
5MP0001984_abnormal_olfaction2.58831262
6MP0002735_abnormal_chemical_nociception2.28463596
7MP0000778_abnormal_nervous_system2.19416150
8MP0005253_abnormal_eye_physiology2.14989849
9MP0005499_abnormal_olfactory_system2.07458302
10MP0005394_taste/olfaction_phenotype2.07458302
11MP0006276_abnormal_autonomic_nervous2.07072570
12MP0002822_catalepsy2.02659685
13MP0005248_abnormal_Harderian_gland1.96442671
14MP0000569_abnormal_digit_pigmentation1.89895479
15MP0003315_abnormal_perineum_morphology1.86573772
16MP0002233_abnormal_nose_morphology1.80022484
17MP0003635_abnormal_synaptic_transmissio1.78711113
18MP0004924_abnormal_behavior1.72188153
19MP0005386_behavior/neurological_phenoty1.72188153
20MP0009780_abnormal_chondrocyte_physiolo1.66510388
21MP0009250_abnormal_appendicular_skeleto1.66318767
22MP0003136_yellow_coat_color1.65699161
23MP0003122_maternal_imprinting1.65263429
24MP0004859_abnormal_synaptic_plasticity1.57930305
25MP0002751_abnormal_autonomic_nervous1.53200907
26MP0002127_abnormal_cardiovascular_syste1.51311556
27MP0002184_abnormal_innervation1.50898618
28MP0002572_abnormal_emotion/affect_behav1.47866934
29MP0003755_abnormal_palate_morphology1.46070542
30MP0009046_muscle_twitch1.45053689
31MP0002160_abnormal_reproductive_system1.44614798
32MP0002132_abnormal_respiratory_system1.43845473
33MP0008789_abnormal_olfactory_epithelium1.41241747
34MP0000566_synostosis1.41044134
35MP0008004_abnormal_stomach_pH1.40232795
36MP0002063_abnormal_learning/memory/cond1.39980880
37MP0000537_abnormal_urethra_morphology1.39793989
38MP0001968_abnormal_touch/_nociception1.38130335
39MP0004270_analgesia1.37409882
40MP0002837_dystrophic_cardiac_calcinosis1.36846308
41MP0000955_abnormal_spinal_cord1.35931385
42MP0004272_abnormal_basement_membrane1.35630246
43MP0000049_abnormal_middle_ear1.35551418
44MP0005187_abnormal_penis_morphology1.31868125
45MP0003935_abnormal_craniofacial_develop1.30851980
46MP0003385_abnormal_body_wall1.28901463
47MP0003787_abnormal_imprinting1.27266394
48MP0002752_abnormal_somatic_nervous1.26075827
49MP0005410_abnormal_fertilization1.25952018
50MP0003938_abnormal_ear_development1.25139370
51MP0002638_abnormal_pupillary_reflex1.24454634
52MP0004084_abnormal_cardiac_muscle1.23811782
53MP0003121_genomic_imprinting1.23792407
54MP0003890_abnormal_embryonic-extraembry1.23788878
55MP0009745_abnormal_behavioral_response1.21750507
56MP0004811_abnormal_neuron_physiology1.18724991
57MP0002295_abnormal_pulmonary_circulatio1.16931883
58MP0002272_abnormal_nervous_system1.14904654
59MP0002108_abnormal_muscle_morphology1.14225587
60MP0002557_abnormal_social/conspecific_i1.14125358
61MP0000749_muscle_degeneration1.13984834
62MP0003937_abnormal_limbs/digits/tail_de1.13428969
63MP0010386_abnormal_urinary_bladder1.13227801
64MP0001486_abnormal_startle_reflex1.12902383
65MP0005646_abnormal_pituitary_gland1.12547872
66MP0005391_vision/eye_phenotype1.11766764
67MP0001905_abnormal_dopamine_level1.11736821
68MP0000026_abnormal_inner_ear1.11482814
69MP0002882_abnormal_neuron_morphology1.08849694
70MP0003698_abnormal_male_reproductive1.08340270
71MP0001270_distended_abdomen1.07117874
72MP0002064_seizures1.06344042
73MP0005551_abnormal_eye_electrophysiolog1.05141663
74MP0004215_abnormal_myocardial_fiber1.01057915
75MP0003221_abnormal_cardiomyocyte_apopto1.00191754
76MP0005503_abnormal_tendon_morphology0.96453283
77MP0004085_abnormal_heartbeat0.95916401
78MP0002734_abnormal_mechanical_nocicepti0.95880759
79MP0001188_hyperpigmentation0.95078887
80MP0001970_abnormal_pain_threshold0.94780888
81MP0010368_abnormal_lymphatic_system0.94406281
82MP0002067_abnormal_sensory_capabilities0.93792199
83MP0002254_reproductive_system_inflammat0.92738165
84MP0003119_abnormal_digestive_system0.92153265
85MP0000631_abnormal_neuroendocrine_gland0.91605621
86MP0001299_abnormal_eye_distance/0.88476132
87MP0002282_abnormal_trachea_morphology0.84859615
88MP0008877_abnormal_DNA_methylation0.84052009
89MP0003861_abnormal_nervous_system0.83081526
90MP0002115_abnormal_skeleton_extremities0.82769461
91MP0001929_abnormal_gametogenesis0.82013039
92MP0004133_heterotaxia0.81218618
93MP0002152_abnormal_brain_morphology0.78866528
94MP0005423_abnormal_somatic_nervous0.76697159
95MP0003137_abnormal_impulse_conducting0.76544407
96MP0002109_abnormal_limb_morphology0.76295097
97MP0005195_abnormal_posterior_eye0.75626427
98MP0004885_abnormal_endolymph0.75081251
99MP0003632_abnormal_nervous_system0.74930021
100MP0001502_abnormal_circadian_rhythm0.74030855

Predicted human phenotypes

RankGene SetZ-score
1Inability to walk (HP:0002540)3.71536172
2Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.65694309
3True hermaphroditism (HP:0010459)3.27531427
4Urinary urgency (HP:0000012)3.26635858
5Abnormality of the columella (HP:0009929)3.17684987
6High anterior hairline (HP:0009890)2.98471450
7Aplasia involving bones of the extremities (HP:0009825)2.94004057
8Aplasia involving bones of the upper limbs (HP:0009823)2.94004057
9Aplasia of the phalanges of the hand (HP:0009802)2.94004057
10Pancreatic fibrosis (HP:0100732)2.87361942
11Retinal dysplasia (HP:0007973)2.85748867
12Abnormality of the frontal sinuses (HP:0002687)2.85436118
13Pachygyria (HP:0001302)2.83645924
14Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.79502031
15Hypothermia (HP:0002045)2.78780035
16Hypoplastic ischia (HP:0003175)2.77730717
17Lissencephaly (HP:0001339)2.77419588
18Vitreoretinal degeneration (HP:0000655)2.75936808
19Volvulus (HP:0002580)2.73050568
20Cerebellar dysplasia (HP:0007033)2.72354359
21Abnormality of midbrain morphology (HP:0002418)2.64230081
22Molar tooth sign on MRI (HP:0002419)2.64230081
23Abnormality of the ischium (HP:0003174)2.63124248
24Hypoplasia of the brainstem (HP:0002365)2.62549574
25Aplasia/Hypoplasia of the brainstem (HP:0007362)2.62549574
26Limb dystonia (HP:0002451)2.57759554
27Long clavicles (HP:0000890)2.57578434
28Type II lissencephaly (HP:0007260)2.52360177
29Median cleft lip (HP:0000161)2.49073594
30Pancreatic cysts (HP:0001737)2.48333812
31Abnormal ciliary motility (HP:0012262)2.48052112
32Absent speech (HP:0001344)2.41205687
33Broad-based gait (HP:0002136)2.37675735
34Short tibia (HP:0005736)2.36926475
35Postaxial foot polydactyly (HP:0001830)2.25136449
36Occipital encephalocele (HP:0002085)2.24371758
37Cupped ear (HP:0000378)2.23609513
38Drooling (HP:0002307)2.23124424
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.20358106
40Delayed gross motor development (HP:0002194)2.18242645
41Male pseudohermaphroditism (HP:0000037)2.16949285
42Abnormal respiratory epithelium morphology (HP:0012253)2.15621441
43Abnormal respiratory motile cilium morphology (HP:0005938)2.15621441
44Abnormality of the labia minora (HP:0012880)2.14224316
45Abnormal respiratory motile cilium physiology (HP:0012261)2.14215321
46Proximal amyotrophy (HP:0007126)2.11303596
47Renal dysplasia (HP:0000110)2.09847789
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09688138
49Abnormality of the calf musculature (HP:0001430)2.08754443
50Thyroid-stimulating hormone excess (HP:0002925)2.07940712
51Atonic seizures (HP:0010819)2.05265764
52Postaxial hand polydactyly (HP:0001162)2.02075696
53Choroideremia (HP:0001139)2.00061384
54Cystic liver disease (HP:0006706)1.99826181
55Resting tremor (HP:0002322)1.99310486
56Excessive salivation (HP:0003781)1.98486362
57Calf muscle hypertrophy (HP:0008981)1.98062061
58Abnormality of the shoulder girdle musculature (HP:0001435)1.97705936
59Hyperventilation (HP:0002883)1.97227205
60Small hand (HP:0200055)1.96922775
61Barrel-shaped chest (HP:0001552)1.96383360
62Hypoventilation (HP:0002791)1.95530596
63Alacrima (HP:0000522)1.91725662
64Decreased lacrimation (HP:0000633)1.91674573
65Preaxial hand polydactyly (HP:0001177)1.89638691
66Nephronophthisis (HP:0000090)1.85281043
67Absent/shortened dynein arms (HP:0200106)1.84323283
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.84323283
69Anencephaly (HP:0002323)1.82431293
70Sclerocornea (HP:0000647)1.82106893
71Hyperglycinemia (HP:0002154)1.81445811
72Focal motor seizures (HP:0011153)1.81220563
73Cortical dysplasia (HP:0002539)1.80735245
74Recurrent corneal erosions (HP:0000495)1.80673999
75Abnormality of the corticospinal tract (HP:0002492)1.80177647
76Mild short stature (HP:0003502)1.76507706
77Bifid scrotum (HP:0000048)1.74700325
78Short 4th metacarpal (HP:0010044)1.74612992
79Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74612992
80Ventricular fibrillation (HP:0001663)1.74348226
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.73032097
82Neoplasm of the adrenal cortex (HP:0100641)1.71438288
83Abnormality of salivation (HP:0100755)1.71409091
84Pancreatic islet-cell hyperplasia (HP:0004510)1.70538271
85Hemiparesis (HP:0001269)1.69798552
86Ulnar claw (HP:0001178)1.68996108
87Chronic hepatic failure (HP:0100626)1.67355301
88Abnormality of the incisor (HP:0000676)1.67134289
89Optic nerve hypoplasia (HP:0000609)1.66340738
90Polyphagia (HP:0002591)1.65681510
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65559512
92Muscle hypertrophy of the lower extremities (HP:0008968)1.65392790
93Aqueductal stenosis (HP:0002410)1.65044633
94Abnormality of the pubic bones (HP:0003172)1.63478257
95Protruding tongue (HP:0010808)1.62759632
96Anterior segment dysgenesis (HP:0007700)1.62228580
97Hepatoblastoma (HP:0002884)1.60128667
98Facial hemangioma (HP:0000329)1.60101609
99Amyotrophic lateral sclerosis (HP:0007354)1.59906767
100Hypoplasia of the uterus (HP:0000013)1.58800184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.06339936
2MARK14.57341989
3PNCK4.00424054
4MAP3K93.38170594
5MAP2K73.27013800
6CASK2.84320134
7LATS12.52112697
8EPHA32.29491730
9MAP3K102.20510980
10TAF12.02863437
11NEK21.99488436
12MARK31.98681919
13EPHA41.97521180
14MAPK131.84350425
15SGK4941.82177245
16SGK2231.82177245
17MYLK1.79693773
18STK38L1.77450275
19FRK1.77433202
20DYRK31.67430573
21CSNK1G11.61594570
22CSNK1A1L1.60508202
23SGK21.56720081
24WNK31.51756185
25CAMK1G1.50357020
26DYRK21.47621886
27CSNK1G31.46526646
28OBSCN1.45242438
29MAP4K21.44787296
30MAP3K41.44311482
31CSNK1G21.36613255
32CDK31.30629149
33CLK11.27625764
34MAPK151.23115570
35ZAK1.22495535
36ERBB31.21658315
37FGFR21.18947230
38BMPR1B1.07914562
39TRIM280.99085979
40MINK10.98535211
41NTRK20.97470672
42ARAF0.90937390
43ADRBK20.89978558
44LATS20.87617092
45INSRR0.85792050
46TNIK0.82992549
47BCR0.82057931
48DDR20.80990280
49NUAK10.80014932
50RPS6KA40.79575228
51CAMK10.78928211
52GRK10.78759561
53RPS6KA20.73675070
54PKN10.68807467
55SGK30.66977967
56VRK10.66256322
57LIMK10.66133567
58GRK50.63458284
59RPS6KB10.62046625
60PLK40.59474651
61MAPKAPK50.58443125
62CDK140.57127965
63PRKCG0.56756896
64CDC42BPA0.55053848
65TLK10.51441239
66PAK30.51353134
67CCNB10.49955371
68CDK50.48633879
69ROCK10.47331845
70RPS6KA50.44648606
71SRPK10.42569417
72CAMK40.42130689
73DYRK1A0.41591760
74TIE10.38689319
75PRKCE0.37675439
76NEK90.35457747
77WEE10.35262635
78ATM0.33121596
79EIF2AK30.33034473
80RPS6KA60.32887955
81MOS0.31739358
82DAPK30.31337598
83CSNK1A10.31305518
84EPHB20.31172187
85CDK180.31149733
86AURKA0.30407490
87AKT30.30176355
88BCKDK0.29820622
89KSR10.29598900
90RPS6KL10.29423271
91RPS6KC10.29423271
92CDK150.28813311
93NEK10.27547181
94CAMK2B0.27424346
95NLK0.27343040
96CSNK1D0.27334243
97UHMK10.27232714
98PRKG10.27025792
99PAK10.26261674
100STK380.26236992

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.80211935
2Olfactory transduction_Homo sapiens_hsa047402.50953856
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47546750
4Butanoate metabolism_Homo sapiens_hsa006502.46395759
5GABAergic synapse_Homo sapiens_hsa047272.26998405
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.25650287
7Hedgehog signaling pathway_Homo sapiens_hsa043402.15838509
8Taste transduction_Homo sapiens_hsa047422.13703341
9Gap junction_Homo sapiens_hsa045402.10325840
10Nicotine addiction_Homo sapiens_hsa050331.91421428
11Circadian entrainment_Homo sapiens_hsa047131.87239076
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80065794
13Axon guidance_Homo sapiens_hsa043601.69180611
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.65094986
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63274490
16Nitrogen metabolism_Homo sapiens_hsa009101.60849035
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.60604234
18Morphine addiction_Homo sapiens_hsa050321.58039613
19Chemical carcinogenesis_Homo sapiens_hsa052041.55743133
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54213202
21Basal transcription factors_Homo sapiens_hsa030221.48940702
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46233958
23Basal cell carcinoma_Homo sapiens_hsa052171.44292148
24Phototransduction_Homo sapiens_hsa047441.41171525
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40651833
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36667385
27Dopaminergic synapse_Homo sapiens_hsa047281.33500885
28Dilated cardiomyopathy_Homo sapiens_hsa054141.27130378
29Salivary secretion_Homo sapiens_hsa049701.26789850
30Propanoate metabolism_Homo sapiens_hsa006401.25843870
31Glutamatergic synapse_Homo sapiens_hsa047241.23544585
32Circadian rhythm_Homo sapiens_hsa047101.22310520
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21902906
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19636056
35Fanconi anemia pathway_Homo sapiens_hsa034601.17076469
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.16628209
37Cocaine addiction_Homo sapiens_hsa050301.15262962
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13131898
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12401895
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12117277
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11313649
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08262108
43Calcium signaling pathway_Homo sapiens_hsa040201.07297145
44Oxytocin signaling pathway_Homo sapiens_hsa049211.07066638
45Arginine biosynthesis_Homo sapiens_hsa002201.06344409
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.05013332
47Alcoholism_Homo sapiens_hsa050341.04223377
48Insulin secretion_Homo sapiens_hsa049111.04172353
49Selenocompound metabolism_Homo sapiens_hsa004501.03645813
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02123494
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.01987265
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01729834
53Melanogenesis_Homo sapiens_hsa049161.00966736
54Wnt signaling pathway_Homo sapiens_hsa043101.00844682
55Steroid biosynthesis_Homo sapiens_hsa001000.99311249
56Oocyte meiosis_Homo sapiens_hsa041140.98616160
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97853182
58Melanoma_Homo sapiens_hsa052180.96390417
59TGF-beta signaling pathway_Homo sapiens_hsa043500.95105124
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91666918
61Dorso-ventral axis formation_Homo sapiens_hsa043200.88805710
62Renin secretion_Homo sapiens_hsa049240.88744160
63Cholinergic synapse_Homo sapiens_hsa047250.86909441
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86105522
65Ovarian steroidogenesis_Homo sapiens_hsa049130.84231717
66beta-Alanine metabolism_Homo sapiens_hsa004100.84129088
67Hippo signaling pathway_Homo sapiens_hsa043900.83659512
68Amphetamine addiction_Homo sapiens_hsa050310.83260723
69Histidine metabolism_Homo sapiens_hsa003400.80186598
70Gastric acid secretion_Homo sapiens_hsa049710.78226957
71Tyrosine metabolism_Homo sapiens_hsa003500.74833855
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72400051
73Phenylalanine metabolism_Homo sapiens_hsa003600.69739634
74RNA degradation_Homo sapiens_hsa030180.68306544
75cAMP signaling pathway_Homo sapiens_hsa040240.68024612
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66301645
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64516138
78Tryptophan metabolism_Homo sapiens_hsa003800.62212457
79Regulation of autophagy_Homo sapiens_hsa041400.61917978
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61384864
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61336909
82Retinol metabolism_Homo sapiens_hsa008300.60513822
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59802358
84AMPK signaling pathway_Homo sapiens_hsa041520.59690979
85Endometrial cancer_Homo sapiens_hsa052130.59406297
86Serotonergic synapse_Homo sapiens_hsa047260.59063871
87Protein digestion and absorption_Homo sapiens_hsa049740.54211253
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53454360
89ECM-receptor interaction_Homo sapiens_hsa045120.53431778
90ABC transporters_Homo sapiens_hsa020100.53331690
91Estrogen signaling pathway_Homo sapiens_hsa049150.52369942
92Purine metabolism_Homo sapiens_hsa002300.51414014
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50543440
94Glutathione metabolism_Homo sapiens_hsa004800.48718538
95Tight junction_Homo sapiens_hsa045300.45565824
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43725403
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42816950
98Arginine and proline metabolism_Homo sapiens_hsa003300.42672170
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40053891
100Linoleic acid metabolism_Homo sapiens_hsa005910.39248155

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