CSNK1G3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.44586243
2nuclear pore complex assembly (GO:0051292)4.31943683
3nuclear pore organization (GO:0006999)4.23883665
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16050277
5synaptic vesicle maturation (GO:0016188)3.86313140
6mitotic sister chromatid cohesion (GO:0007064)3.82097204
7regulation of helicase activity (GO:0051095)3.77501776
8locomotory exploration behavior (GO:0035641)3.77500694
9cytoplasmic mRNA processing body assembly (GO:0033962)3.71596628
10dendrite morphogenesis (GO:0048813)3.65684128
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.46560781
12axonal fasciculation (GO:0007413)3.43652052
13DNA ligation (GO:0006266)3.39387421
14non-recombinational repair (GO:0000726)3.38691356
15double-strand break repair via nonhomologous end joining (GO:0006303)3.38691356
16neural tube formation (GO:0001841)3.37822207
17DNA double-strand break processing (GO:0000729)3.33035441
18neuron recognition (GO:0008038)3.32057210
19neuron cell-cell adhesion (GO:0007158)3.29257777
20cell migration in hindbrain (GO:0021535)3.26452703
21glutamate secretion (GO:0014047)3.26217630
22negative regulation of DNA recombination (GO:0045910)3.23814829
23regulation of centriole replication (GO:0046599)3.23019130
24protein localization to endosome (GO:0036010)3.22569256
25synaptic vesicle exocytosis (GO:0016079)3.22519828
26dendritic spine morphogenesis (GO:0060997)3.21818918
27spindle checkpoint (GO:0031577)3.21326990
28regulation of synaptic vesicle exocytosis (GO:2000300)3.17288923
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.16980496
30SMAD protein complex assembly (GO:0007183)3.15750471
31attachment of spindle microtubules to kinetochore (GO:0008608)3.14730796
32monoubiquitinated protein deubiquitination (GO:0035520)3.13494033
33pore complex assembly (GO:0046931)3.13347543
34exploration behavior (GO:0035640)3.11709114
35kinetochore organization (GO:0051383)3.10454179
36nerve growth factor signaling pathway (GO:0038180)3.09982962
37negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06744041
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06744041
39negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06744041
40negative regulation of mitotic sister chromatid separation (GO:2000816)3.06744041
41negative regulation of sister chromatid segregation (GO:0033046)3.06744041
42establishment of integrated proviral latency (GO:0075713)3.06500731
43mitotic spindle checkpoint (GO:0071174)3.04937950
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.03100393
45regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02893736
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02893736
47regulation of clathrin-mediated endocytosis (GO:2000369)3.02084968
48regulation of sister chromatid segregation (GO:0033045)3.02067596
49regulation of mitotic sister chromatid separation (GO:0010965)3.02067596
50regulation of mitotic sister chromatid segregation (GO:0033047)3.02067596
51response to X-ray (GO:0010165)3.01836964
52microtubule anchoring (GO:0034453)3.00882832
53chromatin remodeling at centromere (GO:0031055)2.99583648
54CENP-A containing nucleosome assembly (GO:0034080)2.99224081
55paraxial mesoderm development (GO:0048339)2.99184228
56negative regulation of chromosome segregation (GO:0051985)2.97632817
57regulation of dendritic spine morphogenesis (GO:0061001)2.96556251
58single strand break repair (GO:0000012)2.95755026
59protein targeting to Golgi (GO:0000042)2.94544280
60neuronal action potential propagation (GO:0019227)2.94326592
61regulation of DNA endoreduplication (GO:0032875)2.93461310
62vesicle transport along microtubule (GO:0047496)2.92430612
63mitotic spindle assembly checkpoint (GO:0007094)2.92186669
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92099280
65establishment of protein localization to Golgi (GO:0072600)2.91136451
66spindle assembly checkpoint (GO:0071173)2.90136037
67cerebral cortex radially oriented cell migration (GO:0021799)2.89998660
68protein localization to kinetochore (GO:0034501)2.88672444
69ribosome assembly (GO:0042255)2.86806598
70vocalization behavior (GO:0071625)2.85063978
71regulation of synaptic vesicle transport (GO:1902803)2.84961713
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.81723553
73membrane budding (GO:0006900)2.81712930
74glutamate receptor signaling pathway (GO:0007215)2.80633049
75protein localization to synapse (GO:0035418)2.80523899
76COPII vesicle coating (GO:0048208)2.80393515
77regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.78066589
78histone exchange (GO:0043486)2.77802814
79clathrin coat assembly (GO:0048268)2.76921030
80asymmetric protein localization (GO:0008105)2.74017737
81intestinal epithelial cell development (GO:0060576)2.73389176
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72965247
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72965247
84positive regulation of mitotic sister chromatid separation (GO:1901970)2.72965247
85regulation of transforming growth factor beta2 production (GO:0032909)2.72452611
86regulation of glutamate receptor signaling pathway (GO:1900449)2.71985067
87negative regulation of neurotransmitter transport (GO:0051589)2.71932110
88regulation of long-term neuronal synaptic plasticity (GO:0048169)2.71851772
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71703435
90neuron remodeling (GO:0016322)2.71511923
91apical protein localization (GO:0045176)2.69416775
92establishment of nucleus localization (GO:0040023)2.67136400
93neurotransmitter secretion (GO:0007269)2.65530289
94presynaptic membrane assembly (GO:0097105)2.65161055
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65018714
96regulation of mitotic spindle checkpoint (GO:1903504)2.65018714
97regulation of chromosome segregation (GO:0051983)2.64562030
98negative regulation of hormone biosynthetic process (GO:0032353)2.63802489
99negative regulation of hormone metabolic process (GO:0032351)2.63802489
100mitotic spindle organization (GO:0007052)2.63638744
101regulation of centrosome cycle (GO:0046605)2.63371223
102gastrulation with mouth forming second (GO:0001702)2.62909387
103organelle disassembly (GO:1903008)2.62390251
104regulation of centrosome duplication (GO:0010824)2.61743243
105cell fate commitment involved in formation of primary germ layer (GO:0060795)2.61450662
106kinetochore assembly (GO:0051382)2.60749156
107regulation of meiosis I (GO:0060631)2.57946673
108fibroblast migration (GO:0010761)2.57329146
109cerebellar granule cell differentiation (GO:0021707)2.55135288
110response to nerve growth factor (GO:1990089)2.55101811
111cellular response to nerve growth factor stimulus (GO:1990090)2.55101811
112sister chromatid segregation (GO:0000819)2.55065891
113negative regulation of neurotransmitter secretion (GO:0046929)2.54638846
114nucleobase catabolic process (GO:0046113)2.54597039
115mating behavior (GO:0007617)2.54431753
116organelle transport along microtubule (GO:0072384)2.54186652
117protein neddylation (GO:0045116)2.53609903
118pyrimidine nucleobase catabolic process (GO:0006208)2.52409958
119axon extension (GO:0048675)2.52346883
120negative regulation of axonogenesis (GO:0050771)2.52112934
121regulation of neuronal synaptic plasticity (GO:0048168)2.51627078
122prepulse inhibition (GO:0060134)2.50914339
123regulation of dendritic spine development (GO:0060998)2.50882263
124negative regulation of axon extension (GO:0030517)2.50100246
125ribonucleoprotein complex disassembly (GO:0032988)2.48312875
126metaphase plate congression (GO:0051310)2.48201107
127growth hormone receptor signaling pathway (GO:0060396)2.47931855
128innervation (GO:0060384)2.47918446
129retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46987121
130negative regulation of DNA-dependent DNA replication (GO:2000104)2.44802022
131cellular response to prostaglandin stimulus (GO:0071379)2.44771363
132protein localization to chromosome, centromeric region (GO:0071459)2.43573190
133cerebellar Purkinje cell differentiation (GO:0021702)2.43278168
134suckling behavior (GO:0001967)2.43224917
135negative regulation of JUN kinase activity (GO:0043508)2.42895185
136presynaptic membrane organization (GO:0097090)2.42696652
137intraciliary transport (GO:0042073)2.41914044
138proline transport (GO:0015824)2.41170192
139somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.40296639
140somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.40296639
141isotype switching (GO:0045190)2.40296639
142adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.39965616
143histone H2A acetylation (GO:0043968)2.38971118
144glial cell proliferation (GO:0014009)2.38501416
145negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.38303882
146magnesium ion transport (GO:0015693)2.37708916
147regulation of ARF protein signal transduction (GO:0032012)2.37600689
148G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.37399152
149peptidyl-tyrosine autophosphorylation (GO:0038083)2.37111447
150anterior/posterior axis specification, embryo (GO:0008595)2.37075167
151lens morphogenesis in camera-type eye (GO:0002089)2.35911906
152positive regulation of filopodium assembly (GO:0051491)2.35572729
153synapse assembly (GO:0007416)2.35357644
154negative regulation of signal transduction by p53 class mediator (GO:1901797)2.34828396
155limb bud formation (GO:0060174)2.34160625
156establishment of viral latency (GO:0019043)2.34126089
157regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33544793
158synapsis (GO:0007129)2.32324927
159ephrin receptor signaling pathway (GO:0048013)2.31594679
160synapse organization (GO:0050808)2.31211248
161negative regulation of fibroblast apoptotic process (GO:2000270)2.31173475
162synaptic transmission, glutamatergic (GO:0035249)2.30960731
163protein localization to chromosome (GO:0034502)2.30811136
164neuron projection morphogenesis (GO:0048812)2.30075711
165ganglion development (GO:0061548)2.29232896
166positive regulation of mitochondrial fission (GO:0090141)2.28657342
167negative regulation of cell aging (GO:0090344)2.28370256
168insulin-like growth factor receptor signaling pathway (GO:0048009)2.27807765
169mitotic metaphase plate congression (GO:0007080)2.27748196
170regulation of growth hormone secretion (GO:0060123)2.27722782
171positive regulation of glycoprotein biosynthetic process (GO:0010560)2.27430234
172microtubule depolymerization (GO:0007019)2.27306674
173peptidyl-threonine phosphorylation (GO:0018107)2.27181256
174protein K6-linked ubiquitination (GO:0085020)2.27044479
175sister chromatid cohesion (GO:0007062)2.26888126
176neuromuscular process controlling balance (GO:0050885)2.26751990
177establishment of chromosome localization (GO:0051303)2.26746826
178DNA damage response, detection of DNA damage (GO:0042769)2.26735809
179regulation of synapse structural plasticity (GO:0051823)2.26628624
180regulation of Rac protein signal transduction (GO:0035020)2.26546528
181neuron-neuron synaptic transmission (GO:0007270)2.26200262
182negative regulation of receptor-mediated endocytosis (GO:0048261)2.25662798
183negative regulation of mitosis (GO:0045839)2.25324285
184cytoskeletal anchoring at plasma membrane (GO:0007016)2.25314407
185positive regulation of cell size (GO:0045793)2.25182459
186neurotransmitter catabolic process (GO:0042135)2.24879778
187glycerophospholipid catabolic process (GO:0046475)2.24358203
188long-term memory (GO:0007616)2.24220381
189DNA topological change (GO:0006265)2.24003624
190glycosphingolipid biosynthetic process (GO:0006688)2.23867399
191postreplication repair (GO:0006301)2.23566462
192regulation of excitatory postsynaptic membrane potential (GO:0060079)2.23418742
193regulation of sister chromatid cohesion (GO:0007063)2.23299360
194protein K11-linked ubiquitination (GO:0070979)2.23143252
195regulation of axon extension involved in axon guidance (GO:0048841)2.22699385
196negative regulation of sodium ion transport (GO:0010766)2.22276194
197neuron projection extension (GO:1990138)2.21287374
198midgut development (GO:0007494)2.21285797
199peptidyl-threonine modification (GO:0018210)2.20932248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.58785675
2EZH2_22144423_ChIP-Seq_EOC_Human3.41480099
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.67693683
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47374235
5GBX2_23144817_ChIP-Seq_PC3_Human2.44690192
6EWS_26573619_Chip-Seq_HEK293_Human2.31550485
7* ELK1_19687146_ChIP-ChIP_HELA_Human2.30657580
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26139326
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24587149
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18740174
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18167208
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.10789020
13TAF15_26573619_Chip-Seq_HEK293_Human2.10231279
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09456783
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08554229
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07546575
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04488016
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01760729
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01760729
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98922080
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.98427222
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94942782
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87985256
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86672797
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84993477
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82967946
27* PIAS1_25552417_ChIP-Seq_VCAP_Human1.81624815
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.81001933
29AR_21572438_ChIP-Seq_LNCaP_Human1.75019841
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74798340
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73886859
32* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73318340
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72493242
34* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71321632
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68539598
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68229955
37E2F7_22180533_ChIP-Seq_HELA_Human1.67823225
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66572787
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65567370
40FUS_26573619_Chip-Seq_HEK293_Human1.64647819
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63062099
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.63006272
43* P300_19829295_ChIP-Seq_ESCs_Human1.62096296
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59424059
45IGF1R_20145208_ChIP-Seq_DFB_Human1.58707639
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58520311
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.57154743
48* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54542372
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.54371820
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53231674
51* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53088209
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.52559676
53* SMAD4_21799915_ChIP-Seq_A2780_Human1.52499886
54TP53_16413492_ChIP-PET_HCT116_Human1.52230974
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.52228201
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49439749
57* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49355838
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49129591
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48238206
60* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47753828
61VDR_22108803_ChIP-Seq_LS180_Human1.46897270
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45572120
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.44854623
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43658108
65AR_21909140_ChIP-Seq_LNCAP_Human1.43637610
66TP53_18474530_ChIP-ChIP_U2OS_Human1.42654051
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42350162
68* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41307317
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40493978
70ZNF274_21170338_ChIP-Seq_K562_Hela1.39876160
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39535361
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.39321405
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.38152655
74STAT3_23295773_ChIP-Seq_U87_Human1.37688622
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37198937
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35944845
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34411019
78DROSHA_22980978_ChIP-Seq_HELA_Human1.34270161
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31575005
80* ARNT_22903824_ChIP-Seq_MCF-7_Human1.31064581
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31010571
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29591422
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28614325
84REST_21632747_ChIP-Seq_MESCs_Mouse1.27993933
85* AR_25329375_ChIP-Seq_VCAP_Human1.25720776
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24544722
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23968938
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23968938
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23594589
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23410536
91* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23105243
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21997582
93* BRD4_25478319_ChIP-Seq_HGPS_Human1.21954880
94* AHR_22903824_ChIP-Seq_MCF-7_Human1.21108679
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20435336
96FOXM1_23109430_ChIP-Seq_U2OS_Human1.18428368
97* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17793785
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.17549875
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17142241
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17142241
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16941101
102ER_23166858_ChIP-Seq_MCF-7_Human1.15680663
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14924548
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.14621051
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13131942
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13056846
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12555992
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.12016764
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11475082
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11351941
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.10737708
112IRF1_19129219_ChIP-ChIP_H3396_Human1.10492388
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10373907
114ESR1_20079471_ChIP-ChIP_T-47D_Human1.08641408
115* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08633445
116* CBP_20019798_ChIP-Seq_JUKART_Human1.08633445
117NANOG_16153702_ChIP-ChIP_HESCs_Human1.07755552
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07752926
119CMYC_18555785_Chip-Seq_ESCs_Mouse1.07411532
120YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07373181
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07300967
122* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07300077
123AR_19668381_ChIP-Seq_PC3_Human1.07294287
124P53_22387025_ChIP-Seq_ESCs_Mouse1.07196697
125TCF4_23295773_ChIP-Seq_U87_Human1.07077344
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07035187
127EST1_17652178_ChIP-ChIP_JURKAT_Human1.06905592
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06430271
129RUNX2_22187159_ChIP-Seq_PCA_Human1.06285519
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.05896430
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05880134
132SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05596505
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05524290
134* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05457452
135TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05304910
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.04559047
137* PRDM14_20953172_ChIP-Seq_ESCs_Human1.04525904
138ISL1_27105846_Chip-Seq_CPCs_Mouse1.04437869
139BCAT_22108803_ChIP-Seq_LS180_Human1.04253649
140FOXO3_23340844_ChIP-Seq_DLD1_Human1.03875217
141* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03837801
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03754531
143TAL1_26923725_Chip-Seq_HPCs_Mouse1.03401389
144SOX9_26525672_Chip-Seq_HEART_Mouse1.02935963
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02902775
146YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02896920
147SMAD4_21741376_ChIP-Seq_HESCs_Human1.02581887
148RXR_22108803_ChIP-Seq_LS180_Human1.01283013
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00029492
150RING1B_27294783_Chip-Seq_ESCs_Mouse0.99587029
151CDX2_22108803_ChIP-Seq_LS180_Human0.99558875
152TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98750139
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97833304
154* CBX2_27304074_Chip-Seq_ESCs_Mouse0.97063746
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.96582271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.56036308
2MP0004270_analgesia3.91328608
3MP0010352_gastrointestinal_tract_polyps3.26465727
4MP0008057_abnormal_DNA_replication3.07047251
5MP0003880_abnormal_central_pattern3.00395950
6MP0010234_abnormal_vibrissa_follicle2.96946233
7MP0003787_abnormal_imprinting2.95021490
8MP0003635_abnormal_synaptic_transmissio2.91532265
9MP0005248_abnormal_Harderian_gland2.76253804
10MP0000778_abnormal_nervous_system2.74854343
11MP0008877_abnormal_DNA_methylation2.63298783
12MP0002063_abnormal_learning/memory/cond2.29840489
13MP0008058_abnormal_DNA_repair2.26908119
14MP0003941_abnormal_skin_development2.22702706
15MP0005187_abnormal_penis_morphology2.22557456
16MP0001188_hyperpigmentation2.15917848
17MP0004957_abnormal_blastocyst_morpholog2.09286995
18MP0002734_abnormal_mechanical_nocicepti2.07172661
19MP0003303_peritoneal_inflammation2.00639772
20MP0001486_abnormal_startle_reflex1.94140269
21MP0002102_abnormal_ear_morphology1.92275739
22MP0002064_seizures1.92005434
23MP0009745_abnormal_behavioral_response1.90527878
24MP0001968_abnormal_touch/_nociception1.89566610
25MP0000537_abnormal_urethra_morphology1.88090032
26MP0008932_abnormal_embryonic_tissue1.83653109
27MP0005360_urolithiasis1.82654618
28MP0005623_abnormal_meninges_morphology1.82578529
29MP0003122_maternal_imprinting1.79991706
30MP0010678_abnormal_skin_adnexa1.77312599
31MP0010094_abnormal_chromosome_stability1.76456906
32MP0002234_abnormal_pharynx_morphology1.76045848
33MP0001440_abnormal_grooming_behavior1.74483676
34MP0009780_abnormal_chondrocyte_physiolo1.73830068
35MP0002572_abnormal_emotion/affect_behav1.69244629
36MP0002272_abnormal_nervous_system1.67812001
37MP0003121_genomic_imprinting1.66268433
38MP0002733_abnormal_thermal_nociception1.66220141
39MP0002184_abnormal_innervation1.65286931
40MP0002233_abnormal_nose_morphology1.65005646
41MP0000569_abnormal_digit_pigmentation1.61038620
42MP0003890_abnormal_embryonic-extraembry1.57521788
43MP0003567_abnormal_fetal_cardiomyocyte1.54933749
44MP0004885_abnormal_endolymph1.54637180
45MP0002735_abnormal_chemical_nociception1.54384489
46MP0000427_abnormal_hair_cycle1.52096151
47MP0003111_abnormal_nucleus_morphology1.51645047
48MP0002751_abnormal_autonomic_nervous1.48892907
49MP0001346_abnormal_lacrimal_gland1.48330360
50MP0000920_abnormal_myelination1.47652129
51MP0003300_gastrointestinal_ulcer1.46230991
52MP0003077_abnormal_cell_cycle1.44643862
53MP0002139_abnormal_hepatobiliary_system1.42224634
54MP0001293_anophthalmia1.42085958
55MP0004272_abnormal_basement_membrane1.41425513
56MP0005275_abnormal_skin_tensile1.40257198
57MP0002084_abnormal_developmental_patter1.39340556
58MP0003329_amyloid_beta_deposits1.38475575
59MP0001501_abnormal_sleep_pattern1.38255004
60MP0009046_muscle_twitch1.37487962
61MP0004742_abnormal_vestibular_system1.37258676
62MP0002697_abnormal_eye_size1.36651785
63MP0001879_abnormal_lymphatic_vessel1.36443840
64MP0000955_abnormal_spinal_cord1.34415353
65MP0003693_abnormal_embryo_hatching1.31714183
66MP0004924_abnormal_behavior1.29254643
67MP0005386_behavior/neurological_phenoty1.29254643
68MP0002067_abnormal_sensory_capabilities1.28882039
69MP0005423_abnormal_somatic_nervous1.27210128
70MP0003937_abnormal_limbs/digits/tail_de1.26634687
71MP0001299_abnormal_eye_distance/1.26306449
72MP0010030_abnormal_orbit_morphology1.26220104
73MP0003718_maternal_effect1.25563751
74MP0009703_decreased_birth_body1.25116165
75MP0002557_abnormal_social/conspecific_i1.24807612
76MP0001286_abnormal_eye_development1.24609275
77MP0006276_abnormal_autonomic_nervous1.23415498
78MP0008438_abnormal_cutaneous_collagen1.23346181
79MP0006054_spinal_hemorrhage1.21183268
80MP0002085_abnormal_embryonic_tissue1.20656516
81MP0001970_abnormal_pain_threshold1.17604929
82MP0002160_abnormal_reproductive_system1.17284701
83MP0003868_abnormal_feces_composition1.16259047
84MP0002152_abnormal_brain_morphology1.16017578
85MP0003935_abnormal_craniofacial_develop1.15699871
86MP0004811_abnormal_neuron_physiology1.14899411
87MP0004197_abnormal_fetal_growth/weight/1.14054366
88MP0001697_abnormal_embryo_size1.14043140
89MP0006072_abnormal_retinal_apoptosis1.13943256
90MP0000049_abnormal_middle_ear1.13584805
91MP0002882_abnormal_neuron_morphology1.12939521
92MP0000350_abnormal_cell_proliferation1.11326020
93MP0002138_abnormal_hepatobiliary_system1.11166016
94MP0003385_abnormal_body_wall1.10666406
95MP0005380_embryogenesis_phenotype1.08674977
96MP0001672_abnormal_embryogenesis/_devel1.08674977
97MP0003861_abnormal_nervous_system1.06927634
98MP0001984_abnormal_olfaction1.06717328
99MP0001340_abnormal_eyelid_morphology1.05523965
100MP0002088_abnormal_embryonic_growth/wei1.03929387
101MP0002736_abnormal_nociception_after1.03857904
102MP0004215_abnormal_myocardial_fiber1.03583449
103MP0000383_abnormal_hair_follicle1.03570580
104MP0003091_abnormal_cell_migration1.01649669
105MP0001177_atelectasis1.01109807
106MP0003984_embryonic_growth_retardation1.00886909
107MP0010368_abnormal_lymphatic_system1.00097631
108MP0001730_embryonic_growth_arrest0.99904958
109MP0004264_abnormal_extraembryonic_tissu0.97899992
110MP0002009_preneoplasia0.97816535
111MP0004858_abnormal_nervous_system0.97572296
112MP0002066_abnormal_motor_capabilities/c0.97547158
113MP0002163_abnormal_gland_morphology0.97485575
114MP0000538_abnormal_urinary_bladder0.97151500
115MP0003221_abnormal_cardiomyocyte_apopto0.95823920
116MP0002177_abnormal_outer_ear0.94227486
117MP0003631_nervous_system_phenotype0.93995131
118MP0000462_abnormal_digestive_system0.93664466
119MP0005167_abnormal_blood-brain_barrier0.92396555
120MP0008007_abnormal_cellular_replicative0.92270487
121MP0001529_abnormal_vocalization0.92264005
122MP0003633_abnormal_nervous_system0.92000880
123MP0004134_abnormal_chest_morphology0.91280615
124MP0003632_abnormal_nervous_system0.90466378
125MP0001485_abnormal_pinna_reflex0.88458162
126MP0009250_abnormal_appendicular_skeleto0.88278654
127MP0004510_myositis0.87458115
128MP0003195_calcinosis0.87127880
129MP0003123_paternal_imprinting0.85795137
130MP0000432_abnormal_head_morphology0.85553825
131MP0002909_abnormal_adrenal_gland0.85552451
132MP0003183_abnormal_peptide_metabolism0.85367590
133MP0000647_abnormal_sebaceous_gland0.84973154
134MP0003950_abnormal_plasma_membrane0.84403819
135MP0000762_abnormal_tongue_morphology0.84394108
136MP0005076_abnormal_cell_differentiation0.83075719
137MP0003634_abnormal_glial_cell0.82785751
138MP0009697_abnormal_copulation0.81959548
139MP0003755_abnormal_palate_morphology0.81000482
140MP0000428_abnormal_craniofacial_morphol0.80894722
141MP0008961_abnormal_basal_metabolism0.80052249
142MP0002086_abnormal_extraembryonic_tissu0.79499296
143MP0002896_abnormal_bone_mineralization0.79424003
144MP0000013_abnormal_adipose_tissue0.79200141
145MP0000653_abnormal_sex_gland0.79021244
146MP0002081_perinatal_lethality0.78477268
147MP0001905_abnormal_dopamine_level0.78335520
148MP0006292_abnormal_olfactory_placode0.77682362
149MP0003786_premature_aging0.77394435
150MP0005367_renal/urinary_system_phenotyp0.77280453
151MP0000516_abnormal_urinary_system0.77280453
152MP0000604_amyloidosis0.76781656
153MP0008569_lethality_at_weaning0.76704392
154MP0002111_abnormal_tail_morphology0.76670710
155MP0002092_abnormal_eye_morphology0.76664846
156MP0008789_abnormal_olfactory_epithelium0.76593848
157MP0003252_abnormal_bile_duct0.76482869
158MP0005499_abnormal_olfactory_system0.76320351
159MP0005394_taste/olfaction_phenotype0.76320351
160MP0002109_abnormal_limb_morphology0.76076705
161MP0000358_abnormal_cell_content/0.75575468
162MP0003119_abnormal_digestive_system0.75465619
163MP0005084_abnormal_gallbladder_morpholo0.74910342
164MP0001119_abnormal_female_reproductive0.74706945
165MP0005391_vision/eye_phenotype0.74503108
166MP0002210_abnormal_sex_determination0.74338034
167MP0009053_abnormal_anal_canal0.73513530
168MP0000534_abnormal_ureter_morphology0.73061823

Predicted human phenotypes

RankGene SetZ-score
1Termporal pattern (HP:0011008)4.27003099
2Insidious onset (HP:0003587)4.27003099
3Focal motor seizures (HP:0011153)3.40931065
4Action tremor (HP:0002345)3.40646544
5Focal seizures (HP:0007359)3.14949910
6Abnormality of the labia minora (HP:0012880)3.03132565
7Drooling (HP:0002307)2.94328868
8Excessive salivation (HP:0003781)2.94328868
9Visual hallucinations (HP:0002367)2.90560639
10Buphthalmos (HP:0000557)2.89911550
11Myokymia (HP:0002411)2.89769506
12Cerebral inclusion bodies (HP:0100314)2.83810817
13Ulnar claw (HP:0001178)2.81776989
14Exotropia (HP:0000577)2.75249478
15Bifid tongue (HP:0010297)2.73782511
16Macroorchidism (HP:0000053)2.71608176
17Nephroblastoma (Wilms tumor) (HP:0002667)2.70152419
18Supranuclear gaze palsy (HP:0000605)2.66352940
19Embryonal renal neoplasm (HP:0011794)2.66295093
20Short tibia (HP:0005736)2.66089228
21Intestinal atresia (HP:0011100)2.57665151
22Aplasia/Hypoplasia of the tibia (HP:0005772)2.57281690
23Renal cortical cysts (HP:0000803)2.53500038
24Colon cancer (HP:0003003)2.53446385
25Hepatoblastoma (HP:0002884)2.52073336
26Hyperventilation (HP:0002883)2.49853921
27Subacute progressive viral hepatitis (HP:0006572)2.49687052
28Segmental peripheral demyelination/remyelination (HP:0003481)2.48160520
29Neoplasm of the adrenal cortex (HP:0100641)2.48133121
30Abnormality of the corticospinal tract (HP:0002492)2.47438873
31Cortical dysplasia (HP:0002539)2.45934155
32Papillary thyroid carcinoma (HP:0002895)2.45348293
33Neurofibrillary tangles (HP:0002185)2.45123213
34Breast carcinoma (HP:0003002)2.44919534
35Progressive inability to walk (HP:0002505)2.44820803
36Atonic seizures (HP:0010819)2.44730998
37Papilledema (HP:0001085)2.43714380
38Genetic anticipation (HP:0003743)2.42623880
39Aqueductal stenosis (HP:0002410)2.42461115
40Abnormality of methionine metabolism (HP:0010901)2.41084115
41Urinary bladder sphincter dysfunction (HP:0002839)2.40880540
42Arterial tortuosity (HP:0005116)2.38800095
43Agitation (HP:0000713)2.36852274
44Medulloblastoma (HP:0002885)2.34064057
45Biliary tract neoplasm (HP:0100574)2.30900017
46Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.30459046
47Progressive cerebellar ataxia (HP:0002073)2.30239007
48Short middle phalanx of the 5th finger (HP:0004220)2.30044965
49Methylmalonic acidemia (HP:0002912)2.29397217
50Mutism (HP:0002300)2.28576307
51Peripheral hypomyelination (HP:0007182)2.28431247
52Amblyopia (HP:0000646)2.26634738
53Absence seizures (HP:0002121)2.25886649
54Fibular aplasia (HP:0002990)2.24523195
55Zonular cataract (HP:0010920)2.24023091
56Absent speech (HP:0001344)2.23715501
57Pancreatic islet-cell hyperplasia (HP:0004510)2.22647047
58Abnormality of the vitamin B12 metabolism (HP:0004341)2.22346354
59Mesomelia (HP:0003027)2.22108911
60Dysmetria (HP:0001310)2.21790327
61Megalencephaly (HP:0001355)2.20455855
62Thickened helices (HP:0000391)2.20161401
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19854857
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.19854857
65Abnormal lung lobation (HP:0002101)2.19753429
66Intention tremor (HP:0002080)2.18097938
67Abnormality of chromosome stability (HP:0003220)2.14811294
68Neoplasm of the small intestine (HP:0100833)2.14666581
69Medial flaring of the eyebrow (HP:0010747)2.13774961
70Abnormality of vitamin B metabolism (HP:0004340)2.13750241
71Transitional cell carcinoma of the bladder (HP:0006740)2.12459266
72Microglossia (HP:0000171)2.12236224
73Hypoplastic labia majora (HP:0000059)2.12234995
74Thyroiditis (HP:0100646)2.11570115
75Onion bulb formation (HP:0003383)2.11512056
76Abnormal hair whorl (HP:0010721)2.10670980
77Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.09091637
78Spastic gait (HP:0002064)2.08706426
79Stereotypic behavior (HP:0000733)2.08347265
80Abnormality of salivation (HP:0100755)2.08211960
81Labial hypoplasia (HP:0000066)2.06907389
82Generalized tonic-clonic seizures (HP:0002069)2.06463342
83Vertebral arch anomaly (HP:0008438)2.05058427
84Bladder carcinoma (HP:0002862)2.03746828
85Bladder neoplasm (HP:0009725)2.03746828
86Vascular tortuosity (HP:0004948)2.03745697
87Inappropriate behavior (HP:0000719)2.03594423
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03080888
89Neoplasm of the oral cavity (HP:0100649)2.01183111
90Broad-based gait (HP:0002136)2.00658654
91Neoplasm of the colon (HP:0100273)1.99182352
92Astrocytoma (HP:0009592)1.98831634
93Abnormality of the astrocytes (HP:0100707)1.98831634
94Ankyloglossia (HP:0010296)1.98542295
95Hypoplastic female external genitalia (HP:0012815)1.96963609
96Urinary urgency (HP:0000012)1.95168224
97Volvulus (HP:0002580)1.93553913
98Coronal craniosynostosis (HP:0004440)1.92537552
99Genital tract atresia (HP:0001827)1.89419632
100Asymmetry of the thorax (HP:0001555)1.89327588
101Fair hair (HP:0002286)1.88660181
102Congenital primary aphakia (HP:0007707)1.88335408
103Hammertoe (HP:0001765)1.85849880
104Dialeptic seizures (HP:0011146)1.85274235
105Hyperthyroidism (HP:0000836)1.85174063
106Nephrogenic diabetes insipidus (HP:0009806)1.84637772
107Curly hair (HP:0002212)1.84588407
108Rhabdomyosarcoma (HP:0002859)1.84549891
109Abnormality of the labia majora (HP:0012881)1.84106704
110Vaginal atresia (HP:0000148)1.83800828
111Shallow orbits (HP:0000586)1.83403900
112Long clavicles (HP:0000890)1.82637405
113Stenosis of the external auditory canal (HP:0000402)1.82573895
114Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.82377365
115Thyroid carcinoma (HP:0002890)1.81181210
116Deep venous thrombosis (HP:0002625)1.81125716
117Ankle clonus (HP:0011448)1.81023711
118Dysdiadochokinesis (HP:0002075)1.80604300
119Gait imbalance (HP:0002141)1.79881283
120Chin dimple (HP:0010751)1.79771841
121Increased number of teeth (HP:0011069)1.79538345
122Scanning speech (HP:0002168)1.79380266
123Ovarian neoplasm (HP:0100615)1.77929399
124Hypothermia (HP:0002045)1.77122297
125Neoplasm of the adrenal gland (HP:0100631)1.75673419
126Facial hemangioma (HP:0000329)1.75588578
127Nuclear cataract (HP:0100018)1.75222014
128Bronchomalacia (HP:0002780)1.75171757
129Blue irides (HP:0000635)1.74931989
130Epileptic encephalopathy (HP:0200134)1.74929897
131Widely spaced teeth (HP:0000687)1.74687222
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.73797667
133Infantile muscular hypotonia (HP:0008947)1.73768927
134Abnormality of the hip-girdle musculature (HP:0001445)1.72886654
135Abnormality of the musculature of the pelvis (HP:0001469)1.72886654
136Postaxial hand polydactyly (HP:0001162)1.72651771
137Abnormal biliary tract morphology (HP:0012440)1.72264118
138Sloping forehead (HP:0000340)1.71294407
139Open mouth (HP:0000194)1.70878060
140Sensory axonal neuropathy (HP:0003390)1.69379554
141Abnormal auditory evoked potentials (HP:0006958)1.68566201
142Abnormality of the phalanges of the 5th finger (HP:0004213)1.67496848
143Postural tremor (HP:0002174)1.67476833
144Glioma (HP:0009733)1.67456403
145Inability to walk (HP:0002540)1.66827355
146Mitral valve prolapse (HP:0001634)1.66811853
147Malignant gastrointestinal tract tumors (HP:0006749)1.66228252
148Gastrointestinal carcinoma (HP:0002672)1.66228252
149Median cleft lip (HP:0000161)1.65200330
150Abnormality of the labia (HP:0000058)1.65017700
151Renal hypoplasia (HP:0000089)1.64873193
152Uterine neoplasm (HP:0010784)1.64716119
153Cystic hygroma (HP:0000476)1.64684053
154Mitral stenosis (HP:0001718)1.64189442
155Shoulder girdle muscle weakness (HP:0003547)1.63699697
156Intellectual disability, moderate (HP:0002342)1.63664886
157Morphological abnormality of the pyramidal tract (HP:0002062)1.63636399
158Abnormality of the clitoris (HP:0000056)1.63530071
159Long foot (HP:0001833)1.62949577
160Poor coordination (HP:0002370)1.62577226
161Embryonal neoplasm (HP:0002898)1.62424717
162Neoplasm of the thyroid gland (HP:0100031)1.62147192
163Abnormality of the pubic bones (HP:0003172)1.61588051
164Delayed gross motor development (HP:0002194)1.61348187
165Cutaneous melanoma (HP:0012056)1.60982155
166Failure to thrive in infancy (HP:0001531)1.60942500
167Aplasia/Hypoplasia of the uvula (HP:0010293)1.60547689
168Abnormality of the phalanges of the 2nd finger (HP:0009541)1.60163460
169Impaired vibration sensation in the lower limbs (HP:0002166)1.60146949
170Spastic tetraparesis (HP:0001285)1.59886455
171Hypoglycemic seizures (HP:0002173)1.59621156
172Broad foot (HP:0001769)1.59479075
173Clitoromegaly (HP:0000057)1.58192003
174Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.57514524
175Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57104148
176Deep palmar crease (HP:0006191)1.56111611
177Akinesia (HP:0002304)1.55573929
178Enlarged penis (HP:0000040)1.55124859
179Hip dysplasia (HP:0001385)1.54965842
180Midline defect of the nose (HP:0004122)1.54835517
181Peripheral demyelination (HP:0011096)1.54249252
182Congenital glaucoma (HP:0001087)1.53716529
183Torticollis (HP:0000473)1.52426195
184Sporadic (HP:0003745)1.50973866
185Genu recurvatum (HP:0002816)1.50773530
186Febrile seizures (HP:0002373)1.49974751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.42604398
2MAP4K23.26569699
3TRIM283.19885614
4KSR22.99811056
5PNCK2.76276996
6MARK12.64996622
7NEK12.63924527
8LATS22.55954196
9LATS12.51108817
10KSR12.46549647
11BRSK22.39716222
12CASK2.30782524
13BUB12.24809070
14EIF2AK32.22797754
15SRPK12.21355897
16NTRK32.09655569
17NTRK12.00344308
18RIPK41.93248407
19MKNK21.91618225
20NUAK11.91252946
21CSNK1G21.89380473
22CSNK1A1L1.83882859
23FGFR21.83488724
24MKNK11.82771827
25MAP3K131.81116762
26PAK61.80678593
27CAMK1G1.77802413
28FRK1.76090372
29MST41.75996640
30EPHA41.75540209
31PLK31.69653360
32DYRK31.67583654
33FGR1.67166597
34MAP3K21.63383971
35STK391.62196426
36CSNK1G31.60632047
37EIF2AK11.58958749
38OXSR11.57119751
39MINK11.56227894
40DMPK1.55238107
41SCYL21.54750525
42WNK31.52637831
43MAP3K41.52413628
44TYRO31.51199153
45PBK1.49232228
46TTK1.47059142
47STK241.45317983
48INSRR1.41117286
49CSNK1G11.38512722
50TNIK1.38119351
51TSSK61.37424403
52PLK21.36084533
53ARAF1.30472704
54PLK41.30238485
55STK111.28490935
56CDC71.28003681
57BRD41.27431394
58RET1.25409959
59MAP2K41.25235399
60BMPR1B1.24405188
61SIK31.23490384
62ERBB41.20225321
63RAF11.18724948
64AKT31.17907420
65BCR1.16717354
66SIK21.14796123
67TAF11.14475928
68PAK31.12235121
69NTRK21.10855942
70PTK2B1.07745958
71STK31.06892202
72WNK11.06482948
73RPS6KA41.06011427
74WEE11.05668522
75CDK51.03713126
76MELK1.03476041
77CAMKK21.00880165
78ZAK0.99245527
79PLK10.87126533
80MAP2K10.85704734
81PINK10.85209405
82ACVR1B0.85108499
83EIF2AK20.83067381
84PTK20.82836084
85MAPK130.79601271
86PDGFRB0.78987604
87FES0.78980958
88CAMKK10.77293760
89TAOK10.76198545
90FGFR10.74855494
91CAMK1D0.74724700
92SGK4940.74606088
93SGK2230.74606088
94STK38L0.74392263
95PRKCE0.73777881
96EPHB20.73310521
97STK160.73082811
98BRSK10.73023005
99MET0.71577164
100CDK140.71048096
101FER0.70996055
102ATM0.70782133
103YES10.70521630
104WNK40.68720199
105MAP3K120.67519102
106HIPK20.67209289
107DYRK1A0.64775937
108NEK90.60257570
109GRK10.59857866
110GRK60.59355413
111CDK60.59088563
112PRKCQ0.58142143
113MAPK100.57722912
114ROCK20.57721526
115BMPR20.57392879
116SGK10.56093652
117DYRK20.55779425
118NEK20.55667285
119ABL20.55592230
120CAMK2A0.53761779
121DAPK20.53160772
122CDK180.52805375
123ALK0.52627415
124ERBB30.52460560
125CDK150.51801349
126FYN0.51381954
127RIPK10.51108811
128PIK3CA0.51073788
129VRK10.50187291
130PDGFRA0.49628785
131MAP2K70.49382066
132PRKD30.49318979
133DDR20.48937673
134CDK90.48790364
135STK380.48528409
136SGK30.47918807
137MAP3K100.47386486
138CDK190.47108049
139PRKCZ0.46920314
140MARK20.46617475
141PRKCH0.46456314
142SGK20.46268429
143BMX0.45469524
144CAMK2B0.44957749
145MST1R0.44783619
146GRK50.44280893
147ATR0.43966313
148FGFR30.42822833
149CSNK1D0.42787013
150CDK11A0.42769101
151CHEK20.42759129
152FLT30.42651655
153AURKB0.41048682
154STK40.40947454
155CHEK10.39898593
156EGFR0.38693217
157CSNK1E0.36615863
158NLK0.36534409
159LIMK10.35977379
160BRAF0.32039745
161ADRBK20.28975147
162NEK60.26944751
163CCNB10.24282492

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.02171014
2Protein export_Homo sapiens_hsa030603.29093007
3Basal transcription factors_Homo sapiens_hsa030222.30378864
4Mismatch repair_Homo sapiens_hsa034302.17846125
5Cell cycle_Homo sapiens_hsa041102.10915493
6Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.06838044
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01554998
8Nitrogen metabolism_Homo sapiens_hsa009101.96169698
9Long-term potentiation_Homo sapiens_hsa047201.95157909
10Circadian rhythm_Homo sapiens_hsa047101.93750930
11Fanconi anemia pathway_Homo sapiens_hsa034601.93711433
12RNA degradation_Homo sapiens_hsa030181.87373038
13Selenocompound metabolism_Homo sapiens_hsa004501.86772877
14RNA transport_Homo sapiens_hsa030131.84850976
15Propanoate metabolism_Homo sapiens_hsa006401.83336738
16Glutamatergic synapse_Homo sapiens_hsa047241.80269570
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80008389
18Long-term depression_Homo sapiens_hsa047301.75960190
19Dorso-ventral axis formation_Homo sapiens_hsa043201.74063699
20Dopaminergic synapse_Homo sapiens_hsa047281.72298750
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67364465
22Amphetamine addiction_Homo sapiens_hsa050311.66865134
23Axon guidance_Homo sapiens_hsa043601.66779685
24Homologous recombination_Homo sapiens_hsa034401.60978257
25Circadian entrainment_Homo sapiens_hsa047131.60625374
26Nicotine addiction_Homo sapiens_hsa050331.60323449
27Cholinergic synapse_Homo sapiens_hsa047251.57673290
28p53 signaling pathway_Homo sapiens_hsa041151.56483250
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54462176
30Nucleotide excision repair_Homo sapiens_hsa034201.53694554
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51385698
32Glioma_Homo sapiens_hsa052141.50268484
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46560715
34Renal cell carcinoma_Homo sapiens_hsa052111.46444618
35Cocaine addiction_Homo sapiens_hsa050301.45988188
36GABAergic synapse_Homo sapiens_hsa047271.45369256
37ErbB signaling pathway_Homo sapiens_hsa040121.40674330
38Estrogen signaling pathway_Homo sapiens_hsa049151.40416375
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40150309
40Proteasome_Homo sapiens_hsa030501.39356277
41Morphine addiction_Homo sapiens_hsa050321.36367731
42mRNA surveillance pathway_Homo sapiens_hsa030151.34052970
43Synaptic vesicle cycle_Homo sapiens_hsa047211.32662529
44Sulfur metabolism_Homo sapiens_hsa009201.30775002
45GnRH signaling pathway_Homo sapiens_hsa049121.29575310
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29435462
47Serotonergic synapse_Homo sapiens_hsa047261.29339179
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26830585
49Renin secretion_Homo sapiens_hsa049241.24989675
50Steroid biosynthesis_Homo sapiens_hsa001001.24844664
51Salivary secretion_Homo sapiens_hsa049701.24457769
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23408045
53Choline metabolism in cancer_Homo sapiens_hsa052311.19030342
54Gastric acid secretion_Homo sapiens_hsa049711.17773524
55Melanogenesis_Homo sapiens_hsa049161.17747008
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.17364889
57Insulin secretion_Homo sapiens_hsa049111.14896161
58One carbon pool by folate_Homo sapiens_hsa006701.14625458
59Oxytocin signaling pathway_Homo sapiens_hsa049211.14150530
60Gap junction_Homo sapiens_hsa045401.13328538
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13312301
62Fatty acid elongation_Homo sapiens_hsa000621.11568216
63VEGF signaling pathway_Homo sapiens_hsa043701.10121783
64Spliceosome_Homo sapiens_hsa030401.09984222
65Olfactory transduction_Homo sapiens_hsa047401.09973454
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09642483
67Alcoholism_Homo sapiens_hsa050341.07919791
68Endometrial cancer_Homo sapiens_hsa052131.07109958
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04498018
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03425780
71Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02194291
72Colorectal cancer_Homo sapiens_hsa052101.01533199
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01367596
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01253736
75Type II diabetes mellitus_Homo sapiens_hsa049300.99659208
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.99593767
77Arginine biosynthesis_Homo sapiens_hsa002200.98551378
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98524735
79cAMP signaling pathway_Homo sapiens_hsa040240.97059928
80Prostate cancer_Homo sapiens_hsa052150.94351222
81mTOR signaling pathway_Homo sapiens_hsa041500.94194692
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93811560
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93214194
84Pancreatic cancer_Homo sapiens_hsa052120.92614626
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92224661
86Bile secretion_Homo sapiens_hsa049760.89049588
87Thyroid hormone synthesis_Homo sapiens_hsa049180.87863689
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.87400133
89Non-small cell lung cancer_Homo sapiens_hsa052230.86482745
90B cell receptor signaling pathway_Homo sapiens_hsa046620.86203554
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85982216
92Base excision repair_Homo sapiens_hsa034100.85064722
93Adherens junction_Homo sapiens_hsa045200.85047886
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84960947
95MAPK signaling pathway_Homo sapiens_hsa040100.83919013
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.83730586
97MicroRNAs in cancer_Homo sapiens_hsa052060.83380089
98Wnt signaling pathway_Homo sapiens_hsa043100.82731686
99Ras signaling pathway_Homo sapiens_hsa040140.81623384
100Proteoglycans in cancer_Homo sapiens_hsa052050.81499101
101Vitamin B6 metabolism_Homo sapiens_hsa007500.79737553
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79585792
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78065147
104Peroxisome_Homo sapiens_hsa041460.75916975
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74244809
106DNA replication_Homo sapiens_hsa030300.73791030
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73387926
108Chemokine signaling pathway_Homo sapiens_hsa040620.73278620
109Melanoma_Homo sapiens_hsa052180.73277796
110Hippo signaling pathway_Homo sapiens_hsa043900.72547389
111Renin-angiotensin system_Homo sapiens_hsa046140.72127974
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71879366
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71592587
114Folate biosynthesis_Homo sapiens_hsa007900.71440838
115Prolactin signaling pathway_Homo sapiens_hsa049170.69814679
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69752842
117Thyroid cancer_Homo sapiens_hsa052160.69342115
118Basal cell carcinoma_Homo sapiens_hsa052170.69299027
119Chronic myeloid leukemia_Homo sapiens_hsa052200.69229595
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69061493
121Oocyte meiosis_Homo sapiens_hsa041140.66472317
122TGF-beta signaling pathway_Homo sapiens_hsa043500.65955225
123Rap1 signaling pathway_Homo sapiens_hsa040150.65597322
124FoxO signaling pathway_Homo sapiens_hsa040680.64916723
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62623597
126Focal adhesion_Homo sapiens_hsa045100.62368390
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62154014
128Caffeine metabolism_Homo sapiens_hsa002320.62129381
129Endocytosis_Homo sapiens_hsa041440.61750525
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60559439
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60315241
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59843605
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59476700
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.59289616
135Ovarian steroidogenesis_Homo sapiens_hsa049130.59196758
136Vitamin digestion and absorption_Homo sapiens_hsa049770.58737511
137Platelet activation_Homo sapiens_hsa046110.57804770
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57717640
139Amoebiasis_Homo sapiens_hsa051460.57519877
140Inositol phosphate metabolism_Homo sapiens_hsa005620.57438437
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57214746
142Purine metabolism_Homo sapiens_hsa002300.57062445
143ECM-receptor interaction_Homo sapiens_hsa045120.56941975
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56733185
145Taste transduction_Homo sapiens_hsa047420.56591575
146Pyrimidine metabolism_Homo sapiens_hsa002400.56314960
147Butanoate metabolism_Homo sapiens_hsa006500.56219019
148Tight junction_Homo sapiens_hsa045300.55203916
149* Hedgehog signaling pathway_Homo sapiens_hsa043400.53679143
150Fatty acid metabolism_Homo sapiens_hsa012120.53239454
151Pyruvate metabolism_Homo sapiens_hsa006200.52590043
152Small cell lung cancer_Homo sapiens_hsa052220.52428459
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51897632
154Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51475273
155African trypanosomiasis_Homo sapiens_hsa051430.50016698
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49286611
157Prion diseases_Homo sapiens_hsa050200.49122940
158Salmonella infection_Homo sapiens_hsa051320.48738439
159Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48430619
160Starch and sucrose metabolism_Homo sapiens_hsa005000.45624072
1612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45049220
162Retinol metabolism_Homo sapiens_hsa008300.42778438
163SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42756386
164Viral carcinogenesis_Homo sapiens_hsa052030.41060856
165Pathways in cancer_Homo sapiens_hsa052000.40919690
166RNA polymerase_Homo sapiens_hsa030200.37387338
167Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37365417
168Protein digestion and absorption_Homo sapiens_hsa049740.36979409
169Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36322648
170Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35921871

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