CSNK1A1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.87599374
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.94218746
3positive regulation of gamma-delta T cell activation (GO:0046645)5.93083805
4positive regulation by symbiont of host defense response (GO:0052509)5.51966358
5modulation by symbiont of host defense response (GO:0052031)5.51966358
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.51966358
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.51966358
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.51966358
9modulation by symbiont of host immune response (GO:0052553)5.51966358
10microglial cell activation (GO:0001774)5.45814771
11regulation of B cell receptor signaling pathway (GO:0050855)5.11186724
12neutrophil mediated immunity (GO:0002446)5.01482220
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.71674022
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.63561424
15positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.62385812
16myeloid leukocyte mediated immunity (GO:0002444)4.42804105
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.42632915
18negative regulation of cell killing (GO:0031342)4.42632915
19cytidine metabolic process (GO:0046087)4.37692260
20cytidine catabolic process (GO:0006216)4.37692260
21cytidine deamination (GO:0009972)4.37692260
22detection of external biotic stimulus (GO:0098581)4.37035556
23cellular extravasation (GO:0045123)4.35859589
24regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.26414031
25macrophage activation (GO:0042116)4.26159029
26regulation of gamma-delta T cell differentiation (GO:0045586)4.24115129
27regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.17365165
28regulation of gamma-delta T cell activation (GO:0046643)4.15141454
29macrophage activation involved in immune response (GO:0002281)4.11954384
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.08471944
31response to host immune response (GO:0052572)4.08471944
32pyrimidine ribonucleoside catabolic process (GO:0046133)4.02499973
33Arp2/3 complex-mediated actin nucleation (GO:0034314)4.01369659
34respiratory burst (GO:0045730)3.99435209
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.98653419
36regulation of interferon-beta biosynthetic process (GO:0045357)3.94877848
37negative T cell selection (GO:0043383)3.78060420
38negative regulation of B cell proliferation (GO:0030889)3.77981673
39detection of biotic stimulus (GO:0009595)3.76420984
40leukocyte migration involved in inflammatory response (GO:0002523)3.67481888
41activated T cell proliferation (GO:0050798)3.66616712
42neutrophil activation (GO:0042119)3.63385235
43regulation of regulatory T cell differentiation (GO:0045589)3.60398171
44leukocyte aggregation (GO:0070486)3.58666924
45regulation of interleukin-6 biosynthetic process (GO:0045408)3.57010077
46response to host (GO:0075136)3.56884463
47response to host defenses (GO:0052200)3.56884463
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.56884463
49interferon-gamma production (GO:0032609)3.50720924
50negative regulation of interleukin-12 production (GO:0032695)3.41503773
51granulocyte activation (GO:0036230)3.39155643
52actin nucleation (GO:0045010)3.38236225
53detection of other organism (GO:0098543)3.33917284
54negative regulation of lymphocyte mediated immunity (GO:0002707)3.33030230
55negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.32465256
56positive regulation of B cell differentiation (GO:0045579)3.29504262
57negative regulation of interleukin-17 production (GO:0032700)3.27977917
58neutrophil activation involved in immune response (GO:0002283)3.26396639
59negative thymic T cell selection (GO:0045060)3.25764995
60DNA deamination (GO:0045006)3.24414966
61positive T cell selection (GO:0043368)3.22260411
62regulation of interleukin-12 biosynthetic process (GO:0045075)3.21795415
63cellular response to interleukin-15 (GO:0071350)3.20895509
64neural tube formation (GO:0001841)3.17325995
65positive regulation of toll-like receptor signaling pathway (GO:0034123)3.14930640
66leukotriene biosynthetic process (GO:0019370)3.14417102
67response to interleukin-15 (GO:0070672)3.13511328
68myeloid cell activation involved in immune response (GO:0002275)3.13240855
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.12294868
70negative regulation of B cell mediated immunity (GO:0002713)3.11496996
71negative regulation of immunoglobulin mediated immune response (GO:0002890)3.11496996
72regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10793054
73pantothenate metabolic process (GO:0015939)3.10393008
74positive regulation of interleukin-1 beta secretion (GO:0050718)3.09955332
75dendritic cell migration (GO:0036336)3.07760193
76production of molecular mediator involved in inflammatory response (GO:0002532)3.06165160
77B cell receptor signaling pathway (GO:0050853)3.04803615
78sequestering of actin monomers (GO:0042989)3.03844110
79negative regulation of T cell mediated immunity (GO:0002710)3.03700197
80regulation of B cell differentiation (GO:0045577)3.03273305
81positive regulation of interleukin-1 production (GO:0032732)3.00751486
82regulation of protein kinase A signaling (GO:0010738)2.91554127
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.90204568
84regulation of alpha-beta T cell proliferation (GO:0046640)2.89688618
85hepatocyte apoptotic process (GO:0097284)2.89023742
86positive regulation of interleukin-1 secretion (GO:0050716)2.88962630
87I-kappaB phosphorylation (GO:0007252)2.88332154
88histone mRNA catabolic process (GO:0071044)2.88118760
89T cell mediated immunity (GO:0002456)2.86766772
90neutrophil chemotaxis (GO:0030593)2.82728927
91cytokine secretion (GO:0050663)2.82340453
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81567123
93cellular defense response (GO:0006968)2.80800619
94negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.77848182
95positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.77241165
96leukotriene metabolic process (GO:0006691)2.76119176
97neutrophil migration (GO:1990266)2.76078399
98positive thymic T cell selection (GO:0045059)2.76018322
99positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75680468
100regulation of interleukin-1 beta secretion (GO:0050706)2.75586799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.17638468
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.07895465
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.93981601
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85625927
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.77147220
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.24235854
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91056467
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88213021
9IGF1R_20145208_ChIP-Seq_DFB_Human2.51109911
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40536304
11RUNX_20019798_ChIP-Seq_JUKART_Human2.38441449
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37574647
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.32753492
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30884184
15MYB_26560356_Chip-Seq_TH2_Human2.17068478
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97808269
17* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94736931
18ER_23166858_ChIP-Seq_MCF-7_Human1.94147287
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93656746
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92242650
21SPI1_23547873_ChIP-Seq_NB4_Human1.78853391
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78548457
23GATA3_27048872_Chip-Seq_THYMUS_Human1.77941463
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77929302
25GATA3_26560356_Chip-Seq_TH2_Human1.74993484
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70599407
27TAF15_26573619_Chip-Seq_HEK293_Human1.68243831
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66183586
29VDR_24787735_ChIP-Seq_THP-1_Human1.59692308
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56258802
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54040812
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51811291
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50656656
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.49848887
35MYB_26560356_Chip-Seq_TH1_Human1.49444376
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47142576
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46338280
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45180587
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45180587
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43995450
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42759405
42GBX2_23144817_ChIP-Seq_PC3_Human1.42479805
43P300_19829295_ChIP-Seq_ESCs_Human1.41355511
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35795513
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35540655
46VDR_22108803_ChIP-Seq_LS180_Human1.33013757
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.32464123
48IRF1_19129219_ChIP-ChIP_H3396_Human1.31690653
49* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31532914
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31392874
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29913890
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24979694
53SPI1_23127762_ChIP-Seq_K562_Human1.24288520
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23528432
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21251199
56FUS_26573619_Chip-Seq_HEK293_Human1.20509328
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.20191682
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18654813
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17712068
60SCL_19346495_ChIP-Seq_HPC-7_Human1.17130446
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15699784
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.15435021
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14664908
64* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12198853
65* CBP_20019798_ChIP-Seq_JUKART_Human1.12198853
66SALL4_22934838_ChIP-ChIP_CD34+_Human1.11021512
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.09194624
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.07981918
69BCAT_22108803_ChIP-Seq_LS180_Human1.07389278
70EWS_26573619_Chip-Seq_HEK293_Human1.07138548
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07033024
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07015515
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04473955
74TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04341399
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03396414
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02676774
77SMRT_27268052_Chip-Seq_Bcells_Human1.02085265
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02024498
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00580086
80GATA3_26560356_Chip-Seq_TH1_Human0.99936989
81SMAD4_21741376_ChIP-Seq_EPCs_Human0.96170337
82* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96159629
83TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94786609
84* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92934838
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92241449
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91855472
87SMAD4_21799915_ChIP-Seq_A2780_Human0.91764242
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90856322
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89595989
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89073687
91NANOG_18555785_Chip-Seq_ESCs_Mouse0.88939440
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88849946
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.88136873
94TCF4_22108803_ChIP-Seq_LS180_Human0.87417226
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.87262906
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87213756
97NANOG_19829295_ChIP-Seq_ESCs_Human0.87077146
98SOX2_19829295_ChIP-Seq_ESCs_Human0.87077146
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87059146
100AR_25329375_ChIP-Seq_VCAP_Human0.86962518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.76178171
2MP0000569_abnormal_digit_pigmentation5.10721557
3MP0005671_abnormal_response_to3.50923850
4MP0008260_abnormal_autophagy3.33372358
5MP0001835_abnormal_antigen_presentation3.30596974
6MP0003787_abnormal_imprinting3.01488066
7MP0009785_altered_susceptibility_to2.69165766
8MP0008877_abnormal_DNA_methylation2.63721658
9MP0001800_abnormal_humoral_immune2.56509536
10MP0002166_altered_tumor_susceptibility2.41075950
11MP0002723_abnormal_immune_serum2.26595630
12MP0002419_abnormal_innate_immunity2.26435544
13MP0005025_abnormal_response_to2.24539218
14MP0002420_abnormal_adaptive_immunity2.12745218
15MP0001819_abnormal_immune_cell2.08177338
16MP0004381_abnormal_hair_follicle2.06540684
17MP0005000_abnormal_immune_tolerance2.01421355
18MP0003436_decreased_susceptibility_to2.00937822
19MP0006082_CNS_inflammation2.00919016
20MP0003221_abnormal_cardiomyocyte_apopto1.99559026
21MP0002452_abnormal_antigen_presenting1.98845436
22MP0003656_abnormal_erythrocyte_physiolo1.97619176
23MP0003303_peritoneal_inflammation1.97495195
24MP0000685_abnormal_immune_system1.96112831
25MP0002277_abnormal_respiratory_mucosa1.95544890
26MP0004883_abnormal_blood_vessel1.94387908
27MP0003763_abnormal_thymus_physiology1.82911684
28MP0002006_tumorigenesis1.78263731
29MP0002132_abnormal_respiratory_system1.78166663
30MP0000015_abnormal_ear_pigmentation1.75596581
31MP0005464_abnormal_platelet_physiology1.73513654
32MP0009764_decreased_sensitivity_to1.66676995
33MP0002398_abnormal_bone_marrow1.64200036
34MP0000716_abnormal_immune_system1.62683187
35MP0002148_abnormal_hypersensitivity_rea1.61654197
36MP0004484_altered_response_of1.59318731
37MP0003121_genomic_imprinting1.55016008
38MP0001790_abnormal_immune_system1.50827692
39MP0005387_immune_system_phenotype1.50827692
40MP0002405_respiratory_system_inflammati1.48953186
41MP0005075_abnormal_melanosome_morpholog1.47245142
42MP0002722_abnormal_immune_system1.46014844
43MP0000689_abnormal_spleen_morphology1.45472034
44MP0001845_abnormal_inflammatory_respons1.43574999
45MP0005174_abnormal_tail_pigmentation1.40431773
46MP0003172_abnormal_lysosome_physiology1.36740756
47MP0003183_abnormal_peptide_metabolism1.34130581
48MP0003866_abnormal_defecation1.33886190
49MP0005451_abnormal_body_composition1.31919801
50MP0000703_abnormal_thymus_morphology1.29151168
51MP0005164_abnormal_response_to1.27648122
52MP0005310_abnormal_salivary_gland1.25876219
53MP0002429_abnormal_blood_cell1.19890128
54MP0000858_altered_metastatic_potential1.18980845
55MP0005410_abnormal_fertilization1.18462517
56MP0000465_gastrointestinal_hemorrhage1.13357318
57MP0009765_abnormal_xenobiotic_induced1.09036895
58MP0003828_pulmonary_edema1.05664936
59MP0003195_calcinosis1.05324611
60MP0001533_abnormal_skeleton_physiology1.03895798
61MP0006054_spinal_hemorrhage1.03267658
62MP0008469_abnormal_protein_level1.02997881
63MP0002332_abnormal_exercise_endurance1.01303389
64MP0000427_abnormal_hair_cycle0.93710921
65MP0005389_reproductive_system_phenotype0.92967051
66MP0002736_abnormal_nociception_after0.90701454
67MP0003300_gastrointestinal_ulcer0.89401872
68MP0002909_abnormal_adrenal_gland0.86096335
69MP0010155_abnormal_intestine_physiology0.85033375
70MP0002095_abnormal_skin_pigmentation0.84324436
71MP0009763_increased_sensitivity_to0.83395021
72MP0001968_abnormal_touch/_nociception0.78842868
73MP0002102_abnormal_ear_morphology0.78231162
74MP0009333_abnormal_splenocyte_physiolog0.76184151
75MP0001545_abnormal_hematopoietic_system0.75920794
76MP0005397_hematopoietic_system_phenotyp0.75920794
77MP0004142_abnormal_muscle_tone0.75806437
78MP0003075_altered_response_to0.75215831
79MP0002928_abnormal_bile_duct0.74430573
80MP0001919_abnormal_reproductive_system0.73209078
81MP0005376_homeostasis/metabolism_phenot0.72056622
82MP0004947_skin_inflammation0.70155697
83MP0008004_abnormal_stomach_pH0.68310086
84MP0005084_abnormal_gallbladder_morpholo0.67749036
85MP0003122_maternal_imprinting0.67537202
86MP0003786_premature_aging0.66867085
87MP0003191_abnormal_cellular_cholesterol0.65457025
88MP0003045_fibrosis0.65201785
89MP0005166_decreased_susceptibility_to0.64250754
90MP0002160_abnormal_reproductive_system0.64096849
91MP0008874_decreased_physiological_sensi0.63588410
92MP0003448_altered_tumor_morphology0.63388659
93MP0004147_increased_porphyrin_level0.61582600
94MP0003632_abnormal_nervous_system0.59421791
95MP0005377_hearing/vestibular/ear_phenot0.55337808
96MP0003878_abnormal_ear_physiology0.55337808
97MP0000249_abnormal_blood_vessel0.55005621
98MP0005584_abnormal_enzyme/coenzyme_acti0.51868335
99MP0000371_diluted_coat_color0.51217845
100MP0004130_abnormal_muscle_cell0.50556804

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.56057157
2Abnormality of T cell number (HP:0011839)5.40743060
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.22693537
4Recurrent bacterial skin infections (HP:0005406)5.20549131
5Optic neuritis (HP:0100653)5.18667831
6Retrobulbar optic neuritis (HP:0100654)5.18667831
7Orchitis (HP:0100796)4.81536836
8Myositis (HP:0100614)4.76088705
9Recurrent abscess formation (HP:0002722)4.69118540
10Gastrointestinal infarctions (HP:0005244)4.29169021
11Elevated erythrocyte sedimentation rate (HP:0003565)4.25966249
12Eczematoid dermatitis (HP:0000976)4.23160008
13Keratoconjunctivitis sicca (HP:0001097)3.98279699
14Stomatitis (HP:0010280)3.82143984
15Encephalitis (HP:0002383)3.69882092
16Keratoconjunctivitis (HP:0001096)3.62122597
17Recurrent fungal infections (HP:0002841)3.50886500
18Recurrent skin infections (HP:0001581)3.47013387
19Recurrent gram-negative bacterial infections (HP:0005420)3.38996624
20Abnormality of macrophages (HP:0004311)3.36666569
21Abnormality of T cells (HP:0002843)3.36444736
22Resting tremor (HP:0002322)3.34448018
23Recurrent cutaneous fungal infections (HP:0011370)3.30293243
24Chronic mucocutaneous candidiasis (HP:0002728)3.30293243
25Peritonitis (HP:0002586)3.25014661
26Leukocytosis (HP:0001974)3.21217903
27Increased IgM level (HP:0003496)3.20058544
28Arterial thrombosis (HP:0004420)3.16423687
29Autoimmune hemolytic anemia (HP:0001890)3.04439251
30Gingival bleeding (HP:0000225)3.01613664
31Eosinophilia (HP:0001880)2.99247771
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.98230472
33Gingivitis (HP:0000230)2.91881065
34Anorexia (HP:0002039)2.88390645
35Abnormality of eosinophils (HP:0001879)2.86842736
36Meningitis (HP:0001287)2.81327476
37Chest pain (HP:0100749)2.81001909
38Amyotrophic lateral sclerosis (HP:0007354)2.76385339
39Vasculitis (HP:0002633)2.74754166
40IgG deficiency (HP:0004315)2.74043933
41Gangrene (HP:0100758)2.73112450
42Acute hepatic failure (HP:0006554)2.73076650
43Hemoptysis (HP:0002105)2.73061246
44Mediastinal lymphadenopathy (HP:0100721)2.65560858
45Granulocytopenia (HP:0001913)2.64857290
46Thyroiditis (HP:0100646)2.62652566
47Chronic obstructive pulmonary disease (HP:0006510)2.62092068
48Obstructive lung disease (HP:0006536)2.62092068
49Aplastic anemia (HP:0001915)2.58826521
50Autoimmune thrombocytopenia (HP:0001973)2.57506218
51Spontaneous hematomas (HP:0007420)2.52761939
52Postural instability (HP:0002172)2.50059263
53Palpebral edema (HP:0100540)2.48743707
54Recurrent bronchitis (HP:0002837)2.46929476
55Hypoproteinemia (HP:0003075)2.46373243
56Absent/shortened dynein arms (HP:0200106)2.43070329
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.43070329
58Urticaria (HP:0001025)2.39179180
59Slow saccadic eye movements (HP:0000514)2.33881375
60Recurrent viral infections (HP:0004429)2.33510603
61Pulmonary embolism (HP:0002204)2.31070344
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30592342
63Episodic fever (HP:0001954)2.29573072
64Genetic anticipation (HP:0003743)2.24504995
65Severe combined immunodeficiency (HP:0004430)2.21582189
66Pulmonary infiltrates (HP:0002113)2.18539287
67Abnormality of the peritoneum (HP:0002585)2.15024032
68Papillary thyroid carcinoma (HP:0002895)2.11778857
69Epistaxis (HP:0000421)2.08126968
70Abnormality of the columella (HP:0009929)2.04245432
71Menstrual irregularities (HP:0000858)2.01791169
72Subacute progressive viral hepatitis (HP:0006572)1.97871529
73Chronic diarrhea (HP:0002028)1.95799490
74Abnormality of the pleura (HP:0002103)1.93607425
75Agitation (HP:0000713)1.92573516
76Pelvic girdle muscle weakness (HP:0003749)1.88763768
77Keratitis (HP:0000491)1.88671939
78Abnormality of T cell physiology (HP:0011840)1.84006551
79Decreased central vision (HP:0007663)1.83662260
80Glomerulopathy (HP:0100820)1.82203096
81Stomach cancer (HP:0012126)1.80120239
82Abnormality of the endocardium (HP:0004306)1.79140267
83Attenuation of retinal blood vessels (HP:0007843)1.79096347
84IgM deficiency (HP:0002850)1.78834215
85Vertigo (HP:0002321)1.77804460
86Hypochromic microcytic anemia (HP:0004840)1.76416603
87Hypergammaglobulinemia (HP:0010702)1.76114990
88Abnormal respiratory motile cilium morphology (HP:0005938)1.75314922
89Abnormal respiratory epithelium morphology (HP:0012253)1.75314922
90Sex reversal (HP:0012245)1.74824030
91Abnormal sex determination (HP:0012244)1.74824030
92Acne (HP:0001061)1.74022450
93Aplasia/Hypoplasia of the macula (HP:0008059)1.72758949
94Polyneuropathy (HP:0001271)1.72416635
95Neoplasm of the tracheobronchial system (HP:0100552)1.72028398
96Microcytic anemia (HP:0001935)1.70745364
97Arthropathy (HP:0003040)1.68185420
98Thyroid carcinoma (HP:0002890)1.67561629
99Thoracolumbar scoliosis (HP:0002944)1.66572108
100Abnormal ciliary motility (HP:0012262)1.65776342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.00520916
2BLK3.58157748
3RIPK43.52031438
4IRAK42.72434058
5FES2.44904269
6TAOK32.38119932
7GRK62.36248850
8CSK2.34626828
9MAP2K32.33938617
10FRK2.26276535
11IKBKE2.06998529
12FGR1.98791610
13TESK21.95905701
14PIK3CG1.90844374
15MAP4K11.88147730
16IRAK11.87096468
17MAP3K121.81627264
18MAP3K51.74035896
19MAP3K61.73641799
20EPHA31.71354555
21SYK1.66425598
22EPHB11.60307180
23JAK31.55408417
24ZAP701.53438635
25MAP3K21.51635265
26GRK51.49662366
27IRAK21.41491238
28PLK21.35663862
29PTK2B1.35025228
30ITK1.30658743
31WNK31.29783606
32TYK21.29558104
33SGK21.29080202
34WNK11.28222820
35MAP3K111.26879577
36LYN1.23195865
37BTK1.21739527
38MAP2K41.20639752
39JAK21.19365420
40MATK1.18186977
41MAP4K21.16969983
42YES11.10775571
43HCK1.09121725
44BMPR21.05168801
45MAP2K70.99029195
46DYRK30.97967142
47MAP3K30.97624262
48ADRBK20.96537532
49TEC0.94926333
50ACVR1B0.94343040
51MARK30.92159017
52SGK4940.91371757
53SGK2230.91371757
54ERBB20.90772171
55PINK10.90727573
56LCK0.90329208
57KDR0.89111174
58MAP3K10.85551838
59NLK0.84870384
60PIM10.84412898
61LRRK20.81322964
62OXSR10.81054423
63TAOK10.79453185
64TNK20.78010031
65DYRK1A0.76400895
66BCR0.76008142
67RAF10.70230681
68RPS6KA50.70052361
69FGFR30.68763032
70CLK10.67303571
71SGK30.67068665
72GRK70.65331252
73CDK190.64895156
74PAK30.63074655
75NEK90.61911549
76DYRK1B0.61054609
77NUAK10.59661541
78CAMKK20.56051133
79PRKCQ0.55269158
80STK38L0.55076974
81FER0.51584891
82CSF1R0.49493007
83KSR20.47031626
84MAP3K40.46575558
85FYN0.44781431
86KIT0.43790091
87JAK10.43716337
88SGK10.43546555
89EGFR0.43380231
90BRD40.42533376
91DAPK20.41147776
92DYRK20.41034363
93STK160.40673696
94STK40.40357390
95ADRBK10.40274909
96RET0.37599898
97CAMK40.37362848
98MAP3K140.37078317
99STK110.33811972
100TAF10.32841189

Predicted pathways (KEGG)

RankGene SetZ-score
1Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.13818238
2Primary immunodeficiency_Homo sapiens_hsa053402.95445470
3Leishmaniasis_Homo sapiens_hsa051402.70959120
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.47774417
5Osteoclast differentiation_Homo sapiens_hsa043802.46399775
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.34106214
7Legionellosis_Homo sapiens_hsa051342.28156448
8Measles_Homo sapiens_hsa051622.27845935
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.27404168
10T cell receptor signaling pathway_Homo sapiens_hsa046602.17636761
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.13469264
12Tuberculosis_Homo sapiens_hsa051522.09138705
13Hematopoietic cell lineage_Homo sapiens_hsa046402.04103975
14Staphylococcus aureus infection_Homo sapiens_hsa051501.97513075
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.91528568
16Malaria_Homo sapiens_hsa051441.87500260
17Proteasome_Homo sapiens_hsa030501.86167915
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.83535590
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83496918
20Antigen processing and presentation_Homo sapiens_hsa046121.71775768
21Chemokine signaling pathway_Homo sapiens_hsa040621.54566795
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44766162
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.43338919
24Salmonella infection_Homo sapiens_hsa051321.37991926
25Phagosome_Homo sapiens_hsa041451.37645763
26Graft-versus-host disease_Homo sapiens_hsa053321.37587113
27B cell receptor signaling pathway_Homo sapiens_hsa046621.37410911
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37081729
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36852409
30Apoptosis_Homo sapiens_hsa042101.34603934
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33823072
32Influenza A_Homo sapiens_hsa051641.31675160
33Autoimmune thyroid disease_Homo sapiens_hsa053201.30596044
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29659000
35Fatty acid biosynthesis_Homo sapiens_hsa000611.28793915
36Regulation of autophagy_Homo sapiens_hsa041401.28605975
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26415065
38Allograft rejection_Homo sapiens_hsa053301.20637544
39Shigellosis_Homo sapiens_hsa051311.19924275
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17915445
41TNF signaling pathway_Homo sapiens_hsa046681.14037196
42Rheumatoid arthritis_Homo sapiens_hsa053231.04498607
43Non-small cell lung cancer_Homo sapiens_hsa052231.04128982
44Herpes simplex infection_Homo sapiens_hsa051681.03484197
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02799371
46Dorso-ventral axis formation_Homo sapiens_hsa043201.01685191
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00531323
48Hepatitis B_Homo sapiens_hsa051610.98932732
49Toxoplasmosis_Homo sapiens_hsa051450.94033834
50Parkinsons disease_Homo sapiens_hsa050120.93905790
51Platelet activation_Homo sapiens_hsa046110.87848676
52Type I diabetes mellitus_Homo sapiens_hsa049400.85984127
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82610268
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78571326
55Pertussis_Homo sapiens_hsa051330.74982742
56Morphine addiction_Homo sapiens_hsa050320.73795644
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72009180
58Prolactin signaling pathway_Homo sapiens_hsa049170.70666291
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.69089454
60Olfactory transduction_Homo sapiens_hsa047400.67748700
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64736904
62Caffeine metabolism_Homo sapiens_hsa002320.64570619
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63209674
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.59683303
65Hepatitis C_Homo sapiens_hsa051600.59462208
66Alzheimers disease_Homo sapiens_hsa050100.59330861
67FoxO signaling pathway_Homo sapiens_hsa040680.58375590
68Collecting duct acid secretion_Homo sapiens_hsa049660.58211863
69Nitrogen metabolism_Homo sapiens_hsa009100.58099030
70Endocytosis_Homo sapiens_hsa041440.57064253
71Circadian rhythm_Homo sapiens_hsa047100.54091043
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51408699
73Viral myocarditis_Homo sapiens_hsa054160.48980555
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.47849797
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46472603
76Cholinergic synapse_Homo sapiens_hsa047250.46471362
77MAPK signaling pathway_Homo sapiens_hsa040100.46418616
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46303006
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46189827
80GABAergic synapse_Homo sapiens_hsa047270.45826502
81Alcoholism_Homo sapiens_hsa050340.44474127
82Systemic lupus erythematosus_Homo sapiens_hsa053220.44055360
83Taste transduction_Homo sapiens_hsa047420.43038305
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41500200
85Oxidative phosphorylation_Homo sapiens_hsa001900.39901008
86Arachidonic acid metabolism_Homo sapiens_hsa005900.38208347
87Phototransduction_Homo sapiens_hsa047440.37134140
88Pancreatic cancer_Homo sapiens_hsa052120.36789469
89VEGF signaling pathway_Homo sapiens_hsa043700.35511072
90Viral carcinogenesis_Homo sapiens_hsa052030.34777715
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34322225
92Ras signaling pathway_Homo sapiens_hsa040140.32992205
93Inositol phosphate metabolism_Homo sapiens_hsa005620.32388401
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31743086
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31254597
96Serotonergic synapse_Homo sapiens_hsa047260.30291220
97Epstein-Barr virus infection_Homo sapiens_hsa051690.29851663
98African trypanosomiasis_Homo sapiens_hsa051430.29774774
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.28437895
100Type II diabetes mellitus_Homo sapiens_hsa049300.27375468

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